NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|41327736|ref|NP_958441|]
View 

epidermal growth factor receptor isoform d precursor [Homo sapiens]

Protein Classification

epidermal growth factor receptor; insulin receptor( domain architecture ID 12013602)

epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates, and is activated by ligand (EGF family)-induced dimerization| insulin receptor is a receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GF_recep_IV pfam14843
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 505-627 2.66e-60

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


:

Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 198.75  E-value: 2.66e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   505 VCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAH 584
Cdd:pfam14843   1 VCDPLCSSEGCWGPGPDQCLSCRNFSRGGTCVESCNILQGEPREYVVNSTCVPCHPECLPQNGTATCSGPGADNCTKCAH 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 41327736   585 YIDGPHCVKTCPAGVMGENNtLVWKYADAGHVCHLCHPNCTYG 627
Cdd:pfam14843  81 FRDGPHCVSSCPSGVLGEND-LIWKYADANGVCQPCHPNCTQG 122
Furin-like pfam00757
Furin-like cysteine rich region;
185-335 1.06e-39

Furin-like cysteine rich region;


:

Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 142.96  E-value: 1.06e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   185 GSCQKCDPSCPNGSCWGAGeeNCQKltkiICAQQCSGRCRgkSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTC 264
Cdd:pfam00757  10 GTMEKCHSCCNNGYCWGPG--HCQK----VCPEQCKKRCT--KPGECCHEQCLGGCTGPNDSDCLACRHFNDEGTCVDQC 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41327736   265 PPlmlynpttyqmdvnpeGKYSFGATCV--KKCPR------NYVVTDHGSCVRACGADsYEMEEDGVRKCKKCEGPCRK 335
Cdd:pfam00757  82 PP----------------GTYQFGWRCVtfKECPKshlpgyNPLVIHNGECVRECPSG-YTEVENNSRKCEPCEGLCPK 143
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 57-168 6.01e-33

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


:

Pssm-ID: 460032  Cd Length: 112  Bit Score: 122.73  E-value: 6.01e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736    57 NCEVVLGNLEITYVQRN---YDLSFLKTIQEVAGYVLIAL-NTVERIPLENLQIIRGNMYYENSYALAVLSNYDanktgL 132
Cdd:pfam01030   1 NCTVIYGNLEITLIDENndsELLSFLSNVEEITGYLLIANtNLVSLSFLPNLRIIRGRNLFDDNYALYILDNPN-----L 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 41327736   133 KELPMRNLQEILHGAVRFSNNPALCNVES-IQWRDIV 168
Cdd:pfam01030  76 TELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 361-481 9.48e-31

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


:

Pssm-ID: 460032  Cd Length: 112  Bit Score: 116.56  E-value: 9.48e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   361 NCTSISGDLHILPVAFRGDSFthtppldpqELDILKTVKEITGFLLIQAWpeNRTDLHAFENLEIIRGRTKQHGQFSLAV 440
Cdd:pfam01030   1 NCTVIYGNLEITLIDENNDSE---------LLSFLSNVEEITGYLLIANT--NLVSLSFLPNLRIIRGRNLFDDNYALYI 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 41327736   441 VSL-NITSLGLRSLKEISDGDVIISGNKNLCYANT-INWKKLF 481
Cdd:pfam01030  70 LDNpNLTELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
 
Name Accession Description Interval E-value
GF_recep_IV pfam14843
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 505-627 2.66e-60

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 198.75  E-value: 2.66e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   505 VCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAH 584
Cdd:pfam14843   1 VCDPLCSSEGCWGPGPDQCLSCRNFSRGGTCVESCNILQGEPREYVVNSTCVPCHPECLPQNGTATCSGPGADNCTKCAH 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 41327736   585 YIDGPHCVKTCPAGVMGENNtLVWKYADAGHVCHLCHPNCTYG 627
Cdd:pfam14843  81 FRDGPHCVSSCPSGVLGEND-LIWKYADANGVCQPCHPNCTQG 122
Furin-like pfam00757
Furin-like cysteine rich region;
185-335 1.06e-39

Furin-like cysteine rich region;


Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 142.96  E-value: 1.06e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   185 GSCQKCDPSCPNGSCWGAGeeNCQKltkiICAQQCSGRCRgkSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTC 264
Cdd:pfam00757  10 GTMEKCHSCCNNGYCWGPG--HCQK----VCPEQCKKRCT--KPGECCHEQCLGGCTGPNDSDCLACRHFNDEGTCVDQC 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41327736   265 PPlmlynpttyqmdvnpeGKYSFGATCV--KKCPR------NYVVTDHGSCVRACGADsYEMEEDGVRKCKKCEGPCRK 335
Cdd:pfam00757  82 PP----------------GTYQFGWRCVtfKECPKshlpgyNPLVIHNGECVRECPSG-YTEVENNSRKCEPCEGLCPK 143
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 57-168 6.01e-33

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 122.73  E-value: 6.01e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736    57 NCEVVLGNLEITYVQRN---YDLSFLKTIQEVAGYVLIAL-NTVERIPLENLQIIRGNMYYENSYALAVLSNYDanktgL 132
Cdd:pfam01030   1 NCTVIYGNLEITLIDENndsELLSFLSNVEEITGYLLIANtNLVSLSFLPNLRIIRGRNLFDDNYALYILDNPN-----L 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 41327736   133 KELPMRNLQEILHGAVRFSNNPALCNVES-IQWRDIV 168
Cdd:pfam01030  76 TELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 361-481 9.48e-31

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 116.56  E-value: 9.48e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   361 NCTSISGDLHILPVAFRGDSFthtppldpqELDILKTVKEITGFLLIQAWpeNRTDLHAFENLEIIRGRTKQHGQFSLAV 440
Cdd:pfam01030   1 NCTVIYGNLEITLIDENNDSE---------LLSFLSNVEEITGYLLIANT--NLVSLSFLPNLRIIRGRNLFDDNYALYI 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 41327736   441 VSL-NITSLGLRSLKEISDGDVIISGNKNLCYANT-INWKKLF 481
Cdd:pfam01030  70 LDNpNLTELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
FU smart00261
Furin-like repeats;
552-598 1.90e-06

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 45.19  E-value: 1.90e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 41327736    552 NSECIQCHPECLpqamniTCTGRGPDNCIQCAH--YIDGPHCVKTCPAG 598
Cdd:smart00261   1 DGECKPCHPECA------TCTGPGPDDCTSCKHgfFLDGGKCVSECPPG 43
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 558-598 4.53e-05

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 41.35  E-value: 4.53e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 41327736 558 CHPECLpqamniTCTGRGPDNCIQCAHYI--DGPHCVKTCPAG 598
Cdd:cd00064   2 CHPSCA------TCTGPGPDQCTSCRHGFylDGGTCVSECPEG 38
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 231-274 1.52e-04

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 39.81  E-value: 1.52e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 41327736 231 CCHNQCAaGCTGPRESDCLVCRKFR--DEATCKDTCPPLMLYNPTT 274
Cdd:cd00064   1 PCHPSCA-TCTGPGPDQCTSCRHGFylDGGTCVSECPEGTYADTEG 45
 
Name Accession Description Interval E-value
GF_recep_IV pfam14843
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 505-627 2.66e-60

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 198.75  E-value: 2.66e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   505 VCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAH 584
Cdd:pfam14843   1 VCDPLCSSEGCWGPGPDQCLSCRNFSRGGTCVESCNILQGEPREYVVNSTCVPCHPECLPQNGTATCSGPGADNCTKCAH 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 41327736   585 YIDGPHCVKTCPAGVMGENNtLVWKYADAGHVCHLCHPNCTYG 627
Cdd:pfam14843  81 FRDGPHCVSSCPSGVLGEND-LIWKYADANGVCQPCHPNCTQG 122
Furin-like pfam00757
Furin-like cysteine rich region;
185-335 1.06e-39

Furin-like cysteine rich region;


Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 142.96  E-value: 1.06e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   185 GSCQKCDPSCPNGSCWGAGeeNCQKltkiICAQQCSGRCRgkSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTC 264
Cdd:pfam00757  10 GTMEKCHSCCNNGYCWGPG--HCQK----VCPEQCKKRCT--KPGECCHEQCLGGCTGPNDSDCLACRHFNDEGTCVDQC 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41327736   265 PPlmlynpttyqmdvnpeGKYSFGATCV--KKCPR------NYVVTDHGSCVRACGADsYEMEEDGVRKCKKCEGPCRK 335
Cdd:pfam00757  82 PP----------------GTYQFGWRCVtfKECPKshlpgyNPLVIHNGECVRECPSG-YTEVENNSRKCEPCEGLCPK 143
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 57-168 6.01e-33

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 122.73  E-value: 6.01e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736    57 NCEVVLGNLEITYVQRN---YDLSFLKTIQEVAGYVLIAL-NTVERIPLENLQIIRGNMYYENSYALAVLSNYDanktgL 132
Cdd:pfam01030   1 NCTVIYGNLEITLIDENndsELLSFLSNVEEITGYLLIANtNLVSLSFLPNLRIIRGRNLFDDNYALYILDNPN-----L 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 41327736   133 KELPMRNLQEILHGAVRFSNNPALCNVES-IQWRDIV 168
Cdd:pfam01030  76 TELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 361-481 9.48e-31

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 116.56  E-value: 9.48e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   361 NCTSISGDLHILPVAFRGDSFthtppldpqELDILKTVKEITGFLLIQAWpeNRTDLHAFENLEIIRGRTKQHGQFSLAV 440
Cdd:pfam01030   1 NCTVIYGNLEITLIDENNDSE---------LLSFLSNVEEITGYLLIANT--NLVSLSFLPNLRIIRGRNLFDDNYALYI 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 41327736   441 VSL-NITSLGLRSLKEISDGDVIISGNKNLCYANT-INWKKLF 481
Cdd:pfam01030  70 LDNpNLTELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
FU smart00261
Furin-like repeats;
552-598 1.90e-06

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 45.19  E-value: 1.90e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 41327736    552 NSECIQCHPECLpqamniTCTGRGPDNCIQCAH--YIDGPHCVKTCPAG 598
Cdd:smart00261   1 DGECKPCHPECA------TCTGPGPDDCTSCKHgfFLDGGKCVSECPPG 43
Furin-like pfam00757
Furin-like cysteine rich region;
497-598 1.72e-05

Furin-like cysteine rich region;


Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 45.12  E-value: 1.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   497 NSCKATGQVCHALCSPEGCWGPEprDCVS-CRnvsrgRECVDKCNllegeprefvENSECiqCHPECLPQamnitCTGRG 575
Cdd:pfam00757   6 DVCPGTMEKCHSCCNNGYCWGPG--HCQKvCP-----EQCKKRCT----------KPGEC--CHEQCLGG-----CTGPN 61

                          90       100
                  ....*....|....*....|...
gi 41327736   576 PDNCIQCAHYIDGPHCVKTCPAG 598
Cdd:pfam00757  62 DSDCLACRHFNDEGTCVDQCPPG 84
GF_recep_IV pfam14843
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 190-265 2.82e-05

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 44.29  E-value: 2.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   190 CDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRG--------KSPSDC--CHNQCA-----AGCTGPRESDCLVCRKF 254
Cdd:pfam14843   2 CDPLCSSEGCWGPGPDQCLSCRNFSRGGTCVESCNIlqgepreyVVNSTCvpCHPECLpqngtATCSGPGADNCTKCAHF 81

                          90
                  ....*....|.
gi 41327736   255 RDEATCKDTCP 265
Cdd:pfam14843  82 RDGPHCVSSCP 92
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 558-598 4.53e-05

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 41.35  E-value: 4.53e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 41327736 558 CHPECLpqamniTCTGRGPDNCIQCAHYI--DGPHCVKTCPAG 598
Cdd:cd00064   2 CHPSCA------TCTGPGPDQCTSCRHGFylDGGTCVSECPEG 38
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 231-274 1.52e-04

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 39.81  E-value: 1.52e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 41327736 231 CCHNQCAaGCTGPRESDCLVCRKFR--DEATCKDTCPPLMLYNPTT 274
Cdd:cd00064   1 PCHPSCA-TCTGPGPDQCTSCRHGFylDGGTCVSECPEGTYADTEG 45
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 506-559 7.09e-03

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 35.19  E-value: 7.09e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 41327736 506 CHALCspEGCWGPEPRDCVSCRNVS--RGRECVDKCnllegePREFVENSECIQCH 559
Cdd:cd00064   2 CHPSC--ATCTGPGPDQCTSCRHGFylDGGTCVSEC------PEGTYADTEGGVCL 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH