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Conserved domains on  [gi|158186629|ref|NP_958757|]
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NEDD4-binding protein 2-like 2 isoform 2 [Mus musculus]

Protein Classification

ATP-binding protein( domain architecture ID 12153064)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain ; similar to Homo sapiens NEDD4-binding protein 2-like 1/2

CATH:  3.40.50.300
Gene Ontology:  GO:0005524|GO:0016887
PubMed:  15037234|18208389|17897320|18466635|16072036|11916378|15037233
SCOP:  2000039

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 396-529 2.34e-20

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


:

Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 87.37  E-value: 2.34e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158186629  396 LILLRGLPGSGKTTLSRILLGQsRDGIVFSTDDYF-----HHQDGYRYNVNQLGDAHDWNQNRAKQAIDQGRsPVIIDNT 470
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEE-LGAVRLSSDDERkrlfgEGRPSISYYTDATDRTYERLHELARIALRAGR-PVILDAT 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 158186629  471 NTQAWEMKPYVEMAIGKGYRVEFHEPETwwkfDPEELEKRNK---------HGVSRKKIAQMLDRYEF 529
Cdd:pfam13671  79 NLRRDERARLLALAREYGVPVRIVVFEA----PEEVLRERLAararaggdpSDVPEEVLDRQKARFEP 142
 
Name Accession Description Interval E-value
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 396-529 2.34e-20

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 87.37  E-value: 2.34e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158186629  396 LILLRGLPGSGKTTLSRILLGQsRDGIVFSTDDYF-----HHQDGYRYNVNQLGDAHDWNQNRAKQAIDQGRsPVIIDNT 470
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEE-LGAVRLSSDDERkrlfgEGRPSISYYTDATDRTYERLHELARIALRAGR-PVILDAT 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 158186629  471 NTQAWEMKPYVEMAIGKGYRVEFHEPETwwkfDPEELEKRNK---------HGVSRKKIAQMLDRYEF 529
Cdd:pfam13671  79 NLRRDERARLLALAREYGVPVRIVVFEA----PEEVLRERLAararaggdpSDVPEEVLDRQKARFEP 142
COG4639 COG4639
Predicted kinase [General function prediction only];
396-528 1.45e-16

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 76.79  E-value: 1.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158186629 396 LILLRGLPGSGKTTLSRILLgqsRDGIVFSTDDyFHHQ--DGYRYNVNQlGDAHDWNQNRAKQAIDQGRsPVIIDNTNTQ 473
Cdd:COG4639    4 LVVLIGLPGSGKSTFARRLF---APTEVVSSDD-IRALlgGDENDQSAW-GDVFQLAHEIARARLRAGR-LTVVDATNLQ 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158186629 474 AWEMKPYVEMAIGKGYRVE---FHEPEtwwkfdpEELEKRNK---HGVSRKKIAQMLDRYE 528
Cdd:COG4639   78 REARRRLLALARAYGALVVavvLDVPL-------EVCLARNAardRQVPEEVIRRMLRRLR 131
pseT PHA02530
polynucleotide kinase; Provisional
 396-512 8.49e-09

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 56.95  E-value: 8.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158186629 396 LILLRGLPGSGKTTLSRILLGQSRDGIVFSTDDY----FHHQ--DGYRYNVNQLGDAHDWNQNRAKQAIDQGRSpVIIDN 469
Cdd:PHA02530   4 IILTVGVPGSGKSTWAREFAAKNPKAVNVNRDDLrqslFGHGewGEYKFTKEKEDLVTKAQEAAALAALKSGKS-VIISD 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 158186629 470 TNTQAWEMKPYVEMAigKGYRVEFHepETWWKFDPEELEKRNK 512
Cdd:PHA02530  83 TNLNPERRRKWKELA--KELGAEFE--EKVFDVPVEELVKRNR 121
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 397-469 1.96e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 38.89  E-value: 1.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158186629   397 ILLRGLPGSGKTTLSRILLGQ----SRDGIVFSTDDYFHHQDGYRYNVNQLGDAHDWNQ-NRAKQAIDQGRSP----VII 467
Cdd:smart00382   5 ILIVGPPGSGKTTLARALARElgppGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGeLRLRLALALARKLkpdvLIL 84


                   ..
gi 158186629   468 DN 469
Cdd:smart00382  85 DE 86
 
Name Accession Description Interval E-value
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 396-529 2.34e-20

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 87.37  E-value: 2.34e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158186629  396 LILLRGLPGSGKTTLSRILLGQsRDGIVFSTDDYF-----HHQDGYRYNVNQLGDAHDWNQNRAKQAIDQGRsPVIIDNT 470
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEE-LGAVRLSSDDERkrlfgEGRPSISYYTDATDRTYERLHELARIALRAGR-PVILDAT 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 158186629  471 NTQAWEMKPYVEMAIGKGYRVEFHEPETwwkfDPEELEKRNK---------HGVSRKKIAQMLDRYEF 529
Cdd:pfam13671  79 NLRRDERARLLALAREYGVPVRIVVFEA----PEEVLRERLAararaggdpSDVPEEVLDRQKARFEP 142
COG4639 COG4639
Predicted kinase [General function prediction only];
396-528 1.45e-16

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 76.79  E-value: 1.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158186629 396 LILLRGLPGSGKTTLSRILLgqsRDGIVFSTDDyFHHQ--DGYRYNVNQlGDAHDWNQNRAKQAIDQGRsPVIIDNTNTQ 473
Cdd:COG4639    4 LVVLIGLPGSGKSTFARRLF---APTEVVSSDD-IRALlgGDENDQSAW-GDVFQLAHEIARARLRAGR-LTVVDATNLQ 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158186629 474 AWEMKPYVEMAIGKGYRVE---FHEPEtwwkfdpEELEKRNK---HGVSRKKIAQMLDRYE 528
Cdd:COG4639   78 REARRRLLALARAYGALVVavvLDVPL-------EVCLARNAardRQVPEEVIRRMLRRLR 131
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
396-510 3.09e-11

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 61.85  E-value: 3.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158186629 396 LILLRGLPGSGKTTLSRIlLGQSRDGIVFSTD--------DYFHHQDGYRyNVNQLGDAHDWnqNRAKQAIDQGRSpVII 467
Cdd:COG0645    1 LILVCGLPGSGKSTLARA-LAERLGAVRLRSDvvrkrlfgAGLAPLERSP-EATARTYARLL--ALARELLAAGRS-VIL 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 158186629 468 DNTNTQAWEMKPYVEMAIGKGYRVEFHEPETwwkfDPEELEKR 510
Cdd:COG0645   76 DATFLRRAQREAFRALAEEAGAPFVLIWLDA----PEEVLRER 114
pseT PHA02530
polynucleotide kinase; Provisional
 396-512 8.49e-09

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 56.95  E-value: 8.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158186629 396 LILLRGLPGSGKTTLSRILLGQSRDGIVFSTDDY----FHHQ--DGYRYNVNQLGDAHDWNQNRAKQAIDQGRSpVIIDN 469
Cdd:PHA02530   4 IILTVGVPGSGKSTWAREFAAKNPKAVNVNRDDLrqslFGHGewGEYKFTKEKEDLVTKAQEAAALAALKSGKS-VIISD 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 158186629 470 TNTQAWEMKPYVEMAigKGYRVEFHepETWWKFDPEELEKRNK 512
Cdd:PHA02530  83 TNLNPERRRKWKELA--KELGAEFE--EKVFDVPVEELVKRNR 121
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 396-475 3.55e-07

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 50.50  E-value: 3.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158186629 396 LILLRGLPGSGKTTLSRILLGQ----SRDGIVFSTDDYFHHQdgyrYNVNQLGDAH-----DWNQNRAKQAIDQGRSpVI 466
Cdd:COG4088    6 LLILTGPPGSGKTTFAKALAQRlyaeGIAVALLHSDDFRRFL----VNESFPKETYeevveDVRTTTADNALDNGYS-VI 80


                 ....*....
gi 158186629 467 IDNTNTQAW 475
Cdd:COG4088   81 VDGTFYYRS 89
Zeta_toxin pfam06414
Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is ...
 393-502 3.28e-05

Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is thought to be part of a postregulational killing system in bacteria. It relies on antitoxin/toxin systems that secure stable inheritance of low and medium copy number plasmids during cell division and kill cells that have lost the plasmid.


Pssm-ID: 428926  Cd Length: 192  Bit Score: 45.05  E-value: 3.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158186629  393 QKLLILLRGLPGSGKTTLSRIL---LGQSRDGIVFSTDDY--FH-------HQDGYRYNVNQLGDAHDWNQNRAKQAIDQ 460
Cdd:pfam06414  10 RPKAILLGGQPGAGKTELARALldeLGRQGNVVRIDPDDFreLHphyrelqAADPKTASEYTQPDASRWVEKLLQHAIEN 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 158186629  461 GRSpVIIDNTNTQAWEMKPYVEMAIGKGYRVEFH----EPETWWKF 502
Cdd:pfam06414  90 GYN-IILEGTLRSPDVAKKIARALKAAGYRVEVAavaaPPELSWLG 134
KTI12 pfam08433
Chromatin associated protein KTI12; This is a family of chromatin associated proteins which ...
 396-528 4.32e-05

Chromatin associated protein KTI12; This is a family of chromatin associated proteins which interact with the Elongator complex, a component of the elongating form of RNA polymerase II. The Elongator complex has histone acetyltransferase activity.


Pssm-ID: 400643  Cd Length: 269  Bit Score: 45.36  E-value: 4.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158186629  396 LILLRGLPGSGKTT----LSRILLGQSRDGIVFSTDDYFHHQDGYRyNVNQLGDAHDWNQNRAKQAIDQGRSpVIIDNTN 471
Cdd:pfam08433   1 LVLLTGLPSSGKSTrakqLAKYLEESNYDVIVISDESLGIEKDDYK-DSAKEKFLRGSLRSAVKRDLSKNTI-VIVDSLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 158186629  472 tqawemkpYVemaigKGYRVEFH-----------------EPETWWKFDPEELEkrnKHGVSRKKIAQMLDRYE 528
Cdd:pfam08433  79 --------YI-----KGFRYELYciakaarttycvihckaPLDLCRKWNEERGQ---KSRYPDELLDALIQRYE 136
AAA_18 pfam13238
AAA domain;
397-520 1.96e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 41.65  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158186629  397 ILLRGLPGSGKTTLSRILlgQSRDGIVFSTDDYFHHQDGYRYNVNQLGDAHDWNQNRAKQAIDqgrspviidntntqawE 476
Cdd:pfam13238   1 ILITGTPGVGKTTLAKEL--SKRLGFGDNVRDLALENGLVLGDDPETRESKRLDEDKLDRLLD----------------L 62

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 158186629  477 MKPYVEMAIGKGYRVEFH----EPETWWKF-------DPEELEKRNKH-GVSRKKI 520
Cdd:pfam13238  63 LEENAALEEGGNLIIDGHlaelEPERAKDLvgivlraSPEELLERLEKrGYEEAKI 118
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 395-449 2.89e-04

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 42.13  E-value: 2.89e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 158186629 395 LLILLRGLPGSGKTTLSRILLGQ--SRDGIVFSTDDYFHHQDGY----RYNVNQLG-DAHDW 449
Cdd:COG0572    8 RIIGIAGPSGSGKTTFARRLAEQlgADKVVVISLDDYYKDREHLpldeRGKPNFDHpEAFDL 69
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 397-469 1.96e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 38.89  E-value: 1.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158186629   397 ILLRGLPGSGKTTLSRILLGQ----SRDGIVFSTDDYFHHQDGYRYNVNQLGDAHDWNQ-NRAKQAIDQGRSP----VII 467
Cdd:smart00382   5 ILIVGPPGSGKTTLARALARElgppGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGeLRLRLALALARKLkpdvLIL 84


                   ..
gi 158186629   468 DN 469
Cdd:smart00382  85 DE 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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