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Conserved domains on  [gi|42558258|ref|NP_976046|]
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F-box only protein 33 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_FBXO33 cd22104
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called ...
 68-115 7.94e-21

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438876  Cd Length: 48  Bit Score: 85.77  E-value: 7.94e-21
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 42558258  68 AASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWPQLRICL 115
Cdd:cd22104   1 WANLPSVVLVHIFSYLPPRDRLRASSTCRRWREALFHPSLWRSLRLHL 48
FBXL3_LRR-like super family cl45928
Leucine-rich repeat domain of FBXL3 and related proteins; F-box/LRR-repeat proteins are part ...
 265-527 1.57e-08

Leucine-rich repeat domain of FBXL3 and related proteins; F-box/LRR-repeat proteins are part of Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase complexes. They contain an F-Box, which binds to the core complex component SKP and a leucine-rich repeat (LRR) domain which gives substrate binding specificity. FBXL3 (F-box and leucine rich repeat protein 3) and FBXL21 have been shown to bind CRY1 repressors and are involved in regulation of circadian clock.


The actual alignment was detected with superfamily member cd23951:

Pssm-ID: 480268 [Multi-domain]  Cd Length: 349  Bit Score: 56.62  E-value: 1.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558258 265 TPTSLSSLSNAVANTMEHLSLLD-NNIPGNSTL-ITAVeLERFVNLHSLALDFCDFTAEMARVLTDSNHVPLQRLSllvh 342
Cdd:cd23951 104 TPVDDPSLQTLASSSSDTLELLKmKSCPRVSPRgILAV-ADHCQHLRELSLNYHLLSDDLLLALSSEEHVRLEHLR---- 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558258 343 nVSVMHKSLDNMP----NDEHWKALSRKSTSFRVYIMAFDIKSEDMLKILKPSIPLERIHFDSYitcVSGAIVDLISRQY 418
Cdd:cd23951 179 -IDVVSENDGPMPlhqiSKESWDALIKHSPDVNLVMYFFVLEDEDFDPFFRSYTPVTHLYFGRS---VPKAVLGRVGQHC 254

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558258 419 DKflthfiLMNDVIDTSGfPDLSDnrneDPLVLLAWRCTKLSLLAIHGYTVWAHNLIAIARLRGSDLKVLEVTEESIdfd 498
Cdd:cd23951 255 PR------LVELVVCANG-NSPID----EELIRIAKNCKQLSSLGLGECEVSCSALVEFAKLCGPRLTELYVMEEVL--- 320

                       250       260
                ....*....|....*....|....*....
gi 42558258 499 qgeLADQDVDPVHnLIEQVSLGLGQPWHA 527
Cdd:cd23951 321 ---VEDEEYDLES-ATAEVSKYLGRDWSP 345
 
Name Accession Description Interval E-value
F-box_FBXO33 cd22104
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called ...
 68-115 7.94e-21

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438876  Cd Length: 48  Bit Score: 85.77  E-value: 7.94e-21
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 42558258  68 AASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWPQLRICL 115
Cdd:cd22104   1 WANLPSVVLVHIFSYLPPRDRLRASSTCRRWREALFHPSLWRSLRLHL 48
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 69-108 2.84e-10

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 55.57  E-value: 2.84e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 42558258    69 ASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALW 108
Cdd:pfam12937   2 SSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLW 41
FBXL3_LRR-like cd23951
Leucine-rich repeat domain of FBXL3 and related proteins; F-box/LRR-repeat proteins are part ...
 265-527 1.57e-08

Leucine-rich repeat domain of FBXL3 and related proteins; F-box/LRR-repeat proteins are part of Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase complexes. They contain an F-Box, which binds to the core complex component SKP and a leucine-rich repeat (LRR) domain which gives substrate binding specificity. FBXL3 (F-box and leucine rich repeat protein 3) and FBXL21 have been shown to bind CRY1 repressors and are involved in regulation of circadian clock.


Pssm-ID: 467830 [Multi-domain]  Cd Length: 349  Bit Score: 56.62  E-value: 1.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558258 265 TPTSLSSLSNAVANTMEHLSLLD-NNIPGNSTL-ITAVeLERFVNLHSLALDFCDFTAEMARVLTDSNHVPLQRLSllvh 342
Cdd:cd23951 104 TPVDDPSLQTLASSSSDTLELLKmKSCPRVSPRgILAV-ADHCQHLRELSLNYHLLSDDLLLALSSEEHVRLEHLR---- 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558258 343 nVSVMHKSLDNMP----NDEHWKALSRKSTSFRVYIMAFDIKSEDMLKILKPSIPLERIHFDSYitcVSGAIVDLISRQY 418
Cdd:cd23951 179 -IDVVSENDGPMPlhqiSKESWDALIKHSPDVNLVMYFFVLEDEDFDPFFRSYTPVTHLYFGRS---VPKAVLGRVGQHC 254

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558258 419 DKflthfiLMNDVIDTSGfPDLSDnrneDPLVLLAWRCTKLSLLAIHGYTVWAHNLIAIARLRGSDLKVLEVTEESIdfd 498
Cdd:cd23951 255 PR------LVELVVCANG-NSPID----EELIRIAKNCKQLSSLGLGECEVSCSALVEFAKLCGPRLTELYVMEEVL--- 320

                       250       260
                ....*....|....*....|....*....
gi 42558258 499 qgeLADQDVDPVHnLIEQVSLGLGQPWHA 527
Cdd:cd23951 321 ---VEDEEYDLES-ATAEVSKYLGRDWSP 345
FBOX smart00256
A Receptor for Ubiquitination Targets;
71-108 4.38e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 40.88  E-value: 4.38e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 42558258     71 LPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALW 108
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFW 38
 
Name Accession Description Interval E-value
F-box_FBXO33 cd22104
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called ...
 68-115 7.94e-21

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438876  Cd Length: 48  Bit Score: 85.77  E-value: 7.94e-21
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 42558258  68 AASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWPQLRICL 115
Cdd:cd22104   1 WANLPSVVLVHIFSYLPPRDRLRASSTCRRWREALFHPSLWRSLRLHL 48
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 69-108 2.84e-10

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 55.57  E-value: 2.84e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 42558258    69 ASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALW 108
Cdd:pfam12937   2 SSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLW 41
FBXL3_LRR-like cd23951
Leucine-rich repeat domain of FBXL3 and related proteins; F-box/LRR-repeat proteins are part ...
 265-527 1.57e-08

Leucine-rich repeat domain of FBXL3 and related proteins; F-box/LRR-repeat proteins are part of Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase complexes. They contain an F-Box, which binds to the core complex component SKP and a leucine-rich repeat (LRR) domain which gives substrate binding specificity. FBXL3 (F-box and leucine rich repeat protein 3) and FBXL21 have been shown to bind CRY1 repressors and are involved in regulation of circadian clock.


Pssm-ID: 467830 [Multi-domain]  Cd Length: 349  Bit Score: 56.62  E-value: 1.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558258 265 TPTSLSSLSNAVANTMEHLSLLD-NNIPGNSTL-ITAVeLERFVNLHSLALDFCDFTAEMARVLTDSNHVPLQRLSllvh 342
Cdd:cd23951 104 TPVDDPSLQTLASSSSDTLELLKmKSCPRVSPRgILAV-ADHCQHLRELSLNYHLLSDDLLLALSSEEHVRLEHLR---- 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558258 343 nVSVMHKSLDNMP----NDEHWKALSRKSTSFRVYIMAFDIKSEDMLKILKPSIPLERIHFDSYitcVSGAIVDLISRQY 418
Cdd:cd23951 179 -IDVVSENDGPMPlhqiSKESWDALIKHSPDVNLVMYFFVLEDEDFDPFFRSYTPVTHLYFGRS---VPKAVLGRVGQHC 254

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558258 419 DKflthfiLMNDVIDTSGfPDLSDnrneDPLVLLAWRCTKLSLLAIHGYTVWAHNLIAIARLRGSDLKVLEVTEESIdfd 498
Cdd:cd23951 255 PR------LVELVVCANG-NSPID----EELIRIAKNCKQLSSLGLGECEVSCSALVEFAKLCGPRLTELYVMEEVL--- 320

                       250       260
                ....*....|....*....|....*....
gi 42558258 499 qgeLADQDVDPVHnLIEQVSLGLGQPWHA 527
Cdd:cd23951 321 ---VEDEEYDLES-ATAEVSKYLGRDWSP 345
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 69-100 3.99e-07

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 46.28  E-value: 3.99e-07
                        10        20        30
                ....*....|....*....|....*....|..
gi 42558258  69 ASLPSELIVHIFSFLPAPDRLRASASCSHWRE 100
Cdd:cd09917   1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRE 32
F-box_FBXL21 cd22179
F-box domain found in F-box/LRR-repeat protein 21 (FBXL21) and similar proteins; FBXL21, also ...
 70-108 1.37e-06

F-box domain found in F-box/LRR-repeat protein 21 (FBXL21) and similar proteins; FBXL21, also called F-box and leucine-rich repeat protein 21, F-box and leucine-rich repeat protein 3B (FBXL3B), or F-box/LRR-repeat protein 3B, is the substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex that mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY protein stabilization, and thus, is involved in circadian rhythm function. It regulates the oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438950  Cd Length: 43  Bit Score: 45.28  E-value: 1.37e-06
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 42558258  70 SLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALW 108
Cdd:cd22179   5 NLPHHVVLHIFQYLPLVDRARASSVCRRWNEVFHIPDLW 43
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
 71-111 1.65e-06

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 44.92  E-value: 1.65e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 42558258  71 LPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWPQL 111
Cdd:cd22117   4 LPYELIQLILSYLDLPSLCRLSQTCKLFRKHCYDPLLWKEL 44
F-box_unchar cd22138
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 ...
 70-108 7.23e-06

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 (FBXO13); The family corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 13 (FBXO13). FBXO13, also called FBX13, or F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438910  Cd Length: 45  Bit Score: 43.09  E-value: 7.23e-06
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 42558258  70 SLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALW 108
Cdd:cd22138   3 SLPVECQLKIFSFLSEVDKCLAATVCRSWSELIRSPRLW 41
F-box_FBXL3 cd22178
F-box domain found in F-box/LRR-repeat protein 3 (FBXL3) and similar proteins; FBXL3, also ...
 69-108 1.73e-05

F-box domain found in F-box/LRR-repeat protein 3 (FBXL3) and similar proteins; FBXL3, also called F-box and leucine-rich repeat protein 3A, or F-box/LRR-repeat protein 3A, is the substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex that mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2, and thus, is involved in circadian rhythm function. It plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438949  Cd Length: 43  Bit Score: 42.20  E-value: 1.73e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 42558258  69 ASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALW 108
Cdd:cd22178   4 GNLLQDIILQIFQYLPLLDRAHASQVCRNWNQVFHMPDLW 43
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
 69-108 2.01e-05

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 41.94  E-value: 2.01e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 42558258  69 ASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALW 108
Cdd:cd22118   2 SSLPPEIMLKIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41
FBXL21_LRR cd23956
Leucine-rich repeat domain of F-box/LRR-repeat protein 21; FBXL21 (F-box/LRR-repeat protein 21) ...
 265-525 2.54e-05

Leucine-rich repeat domain of F-box/LRR-repeat protein 21; FBXL21 (F-box/LRR-repeat protein 21) stabilizes CRY repressor proteins through ubiquitination and therefore counteracts FBXL3. FBXL3 (F-box/LRR-repeat protein 3), together with SKP1 (S-phase-kinase-associated protein-1) and the cullin subunit CUL1, forms a Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase complex that ubiquitinates CRYs mediating their degradation. This plays an important role in oscillation of the circadian clock. FBXL21 has also been shown to regulate myoblast differentiation and sarcomere architecture via Myozenin 1 (MYOZ1; calsarcin-2) ubiquitination and NFAT signaling.


Pssm-ID: 467831 [Multi-domain]  Cd Length: 350  Bit Score: 46.40  E-value: 2.54e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558258 265 TPTSLSSLSNAVANTMEHLSLLD-NNIPGNSTLITAVELERFVNLHSLALDFCDFTAEMARVLTDSNHVPLQRLsllvhN 343
Cdd:cd23956 104 TPVDDPSLKILVANNSDTLRLLKmSSCPHVSSDGILCVADHCQGLRELALNYYILSDELLLALSSETHVNLEHL-----R 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558258 344 VSVMHKSLDNMP----NDEHWKALSRKSTSFRVyIMAFDIKSEDMLKILKPSIPLERIHFDSyitCVSGAIVDLISRQYD 419
Cdd:cd23956 179 IDVVSENPGQIEfhsiKKQSWDALIKHSPGVNV-VMYFFLYEEEFETFFKEETPVTHLYFGR---SVSKAVLGRIGLNCP 254

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558258 420 KflthfiLMNDVIDTSGFPDLsdnrnEDPLVLLAWRCTKLSLLAIHGYTVWAHNLIAIARLRGSDLKVLEVTEESIDFDq 499
Cdd:cd23956 255 R------LIELVVCANGLQPL-----DNELICIAEHCKNLTALGLSECEVSCSAFIEFVRLCGRRLTQLSIMEDVLIPD- 322

                       250       260
                ....*....|....*....|....*.
gi 42558258 500 gelADQDVDPVHNlieQVSLGLGQPW 525
Cdd:cd23956 323 ---DDYSLDEIHT---EVSKYLGRMW 342
FBXL3_LRR cd23957
Leucine-rich repeat domain of F-box/LRR-repeat protein 3; FBXL3 (F-box/LRR-repeat protein 3), ...
 265-529 2.74e-05

Leucine-rich repeat domain of F-box/LRR-repeat protein 3; FBXL3 (F-box/LRR-repeat protein 3), together with SKP1 (S-phase-kinase-associated protein-1) and cullin subunit CUL1, forms a Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase complex that ubiquitinates CRY repressor proteins and mediates their degradation. FBXL21 also ubiquitinates the cryptochromes (CRYs) but counteracts FBXL3. This plays an important role in regulating oscillation of the circadian clock.


Pssm-ID: 467832 [Multi-domain]  Cd Length: 350  Bit Score: 46.58  E-value: 2.74e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558258 265 TPTSLSSLSNAVANTMEHLSLLD-NNIPGNSTLITAVELERFVNLHSLALDFCDFTAEMARVLTDSNHVPLQRLSLLVHN 343
Cdd:cd23957 104 TPVDDPSLKVLVANNSDTLKLLKmSSCPHVSPAGILCVADQCHGLRELALNYYLLSDELLLALSSEKHVRLEHLRIDVVS 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558258 344 VSVMHKSLDNMpNDEHWKALSRKSTSFRVyIMAFDIKSEDMLKILKPSIPLERIHFDSyitCVSGAIVDLISRQYDKflt 423
Cdd:cd23957 184 ENPGQTQFHTI-KKSSWDALIKHSPKVNL-VMYFFLYEEEFDPFFRYETPVTHLYFGR---SVSKEVLGRVGMNCPR--- 255

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558258 424 hfiLMNDVIDTSGFPDLsdnrnEDPLVLLAWRCTKLSLLAIHGYTVWAHNLIAIARLRGSDLKVLEVTEESIDFDQgela 503
Cdd:cd23957 256 ---LVELVVCANGLRPL-----DEELIRIAERCKNLTAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQ---- 323

                       250       260
                ....*....|....*....|....*.
gi 42558258 504 DQDVDPVHnliEQVSLGLGQPWHAVM 529
Cdd:cd23957 324 KYNLEQIH---WEVSKHLGRVWFPDM 346
FBOX smart00256
A Receptor for Ubiquitination Targets;
71-108 4.38e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 40.88  E-value: 4.38e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 42558258     71 LPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALW 108
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFW 38
F-box_FBXO39 cd22108
F-box domain found in F-box only protein 39 (FBXO39) and similar proteins; FBXO39, also called ...
 69-108 5.28e-05

F-box domain found in F-box only protein 39 (FBXO39) and similar proteins; FBXO39, also called FBX39, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a cancer/testis antigen from colon cancer patients by serological analysis of recombinant cDNA expression libraries (SEREX). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438880  Cd Length: 44  Bit Score: 40.48  E-value: 5.28e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 42558258  69 ASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALW 108
Cdd:cd22108   2 ANLPDVCLRHVFRWLGDRDRSRAALVCKRWNQAMYSPALW 41
F-box_FBXL8 cd22121
F-box domain found in F-box/LRR-repeat protein 8 (FBXL8) and similar proteins; FBXL8, also ...
 70-100 6.59e-05

F-box domain found in F-box/LRR-repeat protein 8 (FBXL8) and similar proteins; FBXL8, also called F-box and leucine-rich repeat protein 8, or F-box protein FBL8, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438893  Cd Length: 35  Bit Score: 40.04  E-value: 6.59e-05
                        10        20        30
                ....*....|....*....|....*....|.
gi 42558258  70 SLPSELIVHIFSFLPAPDRLRASASCSHWRE 100
Cdd:cd22121   2 ALPEEILVHIFRHLSLRDRYAAAQVCKHWRE 32
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 70-108 6.70e-05

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 40.41  E-value: 6.70e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 42558258  70 SLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALW 108
Cdd:cd22123   3 QLPENVLLEILSYLPVRDLLRISRVCKRWRRLVYDKTLW 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 70-108 7.11e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 40.22  E-value: 7.11e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 42558258    70 SLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALW 108
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLW 41
F-box_FBXL1 cd22114
F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also ...
 70-108 8.95e-05

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438886  Cd Length: 41  Bit Score: 40.09  E-value: 8.95e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 42558258  70 SLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALW 108
Cdd:cd22114   3 SLPDELLLGIFSCLCLPDLLKVSQVCKRWYRLASDESLW 41
F-box_FBXO45 cd22111
F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called ...
 68-102 9.33e-05

F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called FBX45, or F-box/SPRY domain-containing protein 1, functions as the substrate-recognition component of E3 ubiquitin ligase complexes. It is critical for synaptogenesis, neuronal migration, and synaptic transmission. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438883  Cd Length: 36  Bit Score: 39.57  E-value: 9.33e-05
                        10        20        30
                ....*....|....*....|....*....|....*
gi 42558258  68 AASLPSELIVHIFSFLPAPDRLRASASCSHWRECL 102
Cdd:cd22111   1 AARLPSRVLEVIFSYLDLPDLRNCSLVCKSWYRLL 35
F-box_FBXL3-like cd22116
F-box domain found in F-box/LRR-repeat protein 3 (FBXL3), F-box/LRR-repeat protein 21 (FBXL21) ...
 70-105 2.04e-04

F-box domain found in F-box/LRR-repeat protein 3 (FBXL3), F-box/LRR-repeat protein 21 (FBXL21) and similar proteins; FBXL3, also called F-box and leucine-rich repeat protein 3A, or F-box/LRR-repeat protein 3A, is the substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex that mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2, and thus, is involved in circadian rhythm function. It plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. FBXL21, also called F-box and leucine-rich repeat protein 21, F-box and leucine-rich repeat protein 3B, or F-box/LRR-repeat protein 3B, is the substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex that mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY protein stabilization, and thus, is also involved in circadian rhythm function. It plays regulates the oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438888  Cd Length: 39  Bit Score: 39.04  E-value: 2.04e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 42558258  70 SLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYP 105
Cdd:cd22116   4 NLPSDIILHIFQYLPLLDRAHASLVCRLWNEVFHMP 39
F-box_FBXO31 cd22102
F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called ...
 70-108 2.47e-04

F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438874  Cd Length: 48  Bit Score: 38.95  E-value: 2.47e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 42558258  70 SLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALW 108
Cdd:cd22102   3 DLPPELLVEIFSSLPGTDLPSLAQVCKKFREILNTDTIW 41
F-box_FBXO24 cd22098
F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called ...
 69-114 3.13e-04

F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called FBX24, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It recognizes deacetylated nucleoside diphosphate kinase A (NDPK-A) to enhance its degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438870  Cd Length: 47  Bit Score: 38.46  E-value: 3.13e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 42558258  69 ASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWpqLRIC 114
Cdd:cd22098   3 LDLPPEILDRIISFLPVKDIVSLGQTCRYFHEVCNSEAVW--RRLC 46
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 71-100 6.57e-04

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 37.59  E-value: 6.57e-04
                        10        20        30
                ....*....|....*....|....*....|
gi 42558258  71 LPSELIVHIFSFLPAPDRLRASASCSHWRE 100
Cdd:cd22132   4 LPDSLLLHIFSYLSPKDLLAAGQVCKQWYR 33
F-box_FBXO18 cd22095
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ...
 71-100 1.91e-03

F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438867  Cd Length: 48  Bit Score: 36.48  E-value: 1.91e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 42558258  71 LPSELIVHIFSFLPAPDRLR-ASASCSHWRE 100
Cdd:cd22095   5 LPEELLRNIFAFLPAEDLYQnISLVCRHWRD 35
F-box_FBXO48 cd22113
F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called ...
 70-100 2.53e-03

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438885  Cd Length: 46  Bit Score: 36.14  E-value: 2.53e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 42558258  70 SLPSELIVHIFSFLPAPDRLRASASCSHWRE 100
Cdd:cd22113   3 LLPPEMSLRIFSQLDVQSLCRASQTCKTWND 33
F-box_AtSKIP5-like cd22163
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar ...
 75-108 2.84e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar proteins; AtSKIP5, also called F-box protein SKIP5, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438934  Cd Length: 46  Bit Score: 35.78  E-value: 2.84e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 42558258  75 LIVHIFSFL-PAPDRLRASASCSHWRECLFYPALW 108
Cdd:cd22163   8 CLMHIFSFLtPLPDRFNAARVCKRWRALALDPRSW 42
F-box_FBXL6 cd22119
F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also ...
 70-108 3.10e-03

F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also called F-box and leucine-rich repeat protein 6, or F-box protein FBL6 (FBL6A), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438891  Cd Length: 47  Bit Score: 35.69  E-value: 3.10e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 42558258  70 SLPSELIVHIFSFL-----PAPDRLRASASCSHWRECLFYPALW 108
Cdd:cd22119   3 RLPPEILVKIFQFAvategAVPLLCRLSRVCRLWREVALDPSLW 46
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
 70-108 6.66e-03

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 34.93  E-value: 6.66e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 42558258  70 SLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALW 108
Cdd:cd22084   3 DLPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLW 41
F-box_FBXO6-like cd22168
F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily ...
 71-116 8.02e-03

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438939 [Multi-domain]  Cd Length: 82  Bit Score: 35.72  E-value: 8.02e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 42558258  71 LPSELIVHIFSFLPAPDRLRA-SASCSHWRECLFYPALWPqlRICLR 116
Cdd:cd22168   7 LPEDVLLEILSLVPARDLILScRLVCSRWRDLVDLPTLWK--RKCQR 51
F-box_FBXL14 cd22125
F-box domain found in F-box/LRR-repeat protein 14 (FBXL14) and similar proteins; FBXL14, also ...
 69-108 8.10e-03

F-box domain found in F-box/LRR-repeat protein 14 (FBXL14) and similar proteins; FBXL14, also called F-box and leucine-rich repeat protein 14, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complex, which acts by mediating ubiquitination and subsequent degradation of SNAIL1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438897  Cd Length: 41  Bit Score: 34.37  E-value: 8.10e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 42558258  69 ASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALW 108
Cdd:cd22125   1 SCLFPEILAMIFSYLDVRDKGRAAQVCTAWRDAAYHKSVW 40
F-box_AtTIR1-like cd22159
F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), ...
 70-100 9.34e-03

F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), coronatine-insensitive protein 1 (COI1) and similar proteins; TIR1, also called F-box/LRR-repeat protein 1 (FBL1), is part of an SCF (SKP1-cullin-F-box) protein ligase complex that promotes the ubiquitin-dependent proteolysis of a family of transcriptional regulators known as Aux/IAAs in an auxin-dependent manner. TIR1 is an auxin receptor that plays a potential role in plant hormone signaling. COI1, also called F-box/LRR-repeat protein 2 (FBL2), is the substrate-recruiting module of an SCF ubiquitin E3 ligase complex. It mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of transcriptional repressor JASMONATE ZIM-domain (JAZ) family proteins. This subfamily also includes Arabidopsis thaliana EIN3-binding F-box protein 1 (EBF1). EBF1, also called F-box/LRR-repeat protein 6 (FBL6), is a component of the SCF(EBF1) E3 ubiquitin ligase complex, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438930  Cd Length: 40  Bit Score: 34.36  E-value: 9.34e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 42558258  70 SLPSELIVHIFSFLPAP-DRLRASASCSHWRE 100
Cdd:cd22159   3 LLPDEILELIFSYLSDPwDRNSCSLVCKRWYR 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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