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Conserved domains on  [gi|45184883|ref|NP_982601|]
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AAR060Cp [Eremothecium gossypii ATCC 10895]

Protein Classification

SWIB_like domain-containing protein( domain architecture ID 12970701)

SWIB_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SWIB_like cd10568
SWIB domain found in the 60 kda subunit of the ATP-dependent SWI/SNF chromatin-remodeling ...
 218-302 1.78e-11

SWIB domain found in the 60 kda subunit of the ATP-dependent SWI/SNF chromatin-remodeling complexes and similar proteins; SWIB domain is a conserved region found within proteins in the SWI/SNF family of complexes. SWI/SNF complex proteins display helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The mammalian complexes are made up of 9-12 proteins called BAFs (BRG1-associated factors), among which the BAF60 subunit serves as a key link between the core complexes and specific transcriptional factors. The BAF60 subunit have at least three members: BAF60a, which is ubiquitous, BAF60b and BAF60c, which are expressed in muscle and pancreatic tissues, respectively. The family also includes Saccharomyces cerevisiae transcription regulatory protein SNF12 and remodel the structure of chromatin complex subunit 6 (RSC6), and Schizosaccharomyces pombe SWI/SNF and RSC complexes subunit SSR3. SNF12, also termed 73-kDa subunit of the SWI/SNF transcriptional regulatory complex, or SWI/SNF complex component SWP73, is involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). RSC6 and SSR3 are components of the RSC, which is involved in transcription regulation and nucleosome positioning. RSC6 is essential for mitotic growth and suppresses formamide sensitivity of the RSC8 mutants.


:

Pssm-ID: 349490 [Multi-domain]  Cd Length: 69  Bit Score: 59.47  E-value: 1.78e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45184883 218 YSDALAFIIGVARGTVHEAIYSLYKYILLNELLvaDPsgnakstqnDDKMVIKVDAMIAKLLPPaaeprKYLKLTELPQV 297
Cdd:cd10568   1 LSPALAQLLGIKEGTRPNIIYALWQYIKLNKLQ--DP---------EDRRLINCDEALKQLFGV-----ERFKFSELPEL 64


                ....*
gi 45184883 298 VNAHI 302
Cdd:cd10568  65 LNPHL 69
 
Name Accession Description Interval E-value
SWIB_like cd10568
SWIB domain found in the 60 kda subunit of the ATP-dependent SWI/SNF chromatin-remodeling ...
 218-302 1.78e-11

SWIB domain found in the 60 kda subunit of the ATP-dependent SWI/SNF chromatin-remodeling complexes and similar proteins; SWIB domain is a conserved region found within proteins in the SWI/SNF family of complexes. SWI/SNF complex proteins display helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The mammalian complexes are made up of 9-12 proteins called BAFs (BRG1-associated factors), among which the BAF60 subunit serves as a key link between the core complexes and specific transcriptional factors. The BAF60 subunit have at least three members: BAF60a, which is ubiquitous, BAF60b and BAF60c, which are expressed in muscle and pancreatic tissues, respectively. The family also includes Saccharomyces cerevisiae transcription regulatory protein SNF12 and remodel the structure of chromatin complex subunit 6 (RSC6), and Schizosaccharomyces pombe SWI/SNF and RSC complexes subunit SSR3. SNF12, also termed 73-kDa subunit of the SWI/SNF transcriptional regulatory complex, or SWI/SNF complex component SWP73, is involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). RSC6 and SSR3 are components of the RSC, which is involved in transcription regulation and nucleosome positioning. RSC6 is essential for mitotic growth and suppresses formamide sensitivity of the RSC8 mutants.


Pssm-ID: 349490 [Multi-domain]  Cd Length: 69  Bit Score: 59.47  E-value: 1.78e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45184883 218 YSDALAFIIGVARGTVHEAIYSLYKYILLNELLvaDPsgnakstqnDDKMVIKVDAMIAKLLPPaaeprKYLKLTELPQV 297
Cdd:cd10568   1 LSPALAQLLGIKEGTRPNIIYALWQYIKLNKLQ--DP---------EDRRLINCDEALKQLFGV-----ERFKFSELPEL 64


                ....*
gi 45184883 298 VNAHI 302
Cdd:cd10568  65 LNPHL 69
SWIB pfam02201
SWIB/MDM2 domain; This family includes the SWIB domain and the MDM2 domain. The p53-associated ...
 219-302 7.03e-05

SWIB/MDM2 domain; This family includes the SWIB domain and the MDM2 domain. The p53-associated protein (MDM2) is an inhibitor of the p53 tumour suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. This family contains the p53 binding domain of MDM2.


Pssm-ID: 460488 [Multi-domain]  Cd Length: 73  Bit Score: 40.93  E-value: 7.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45184883   219 SDALAFIIGVARGTVHEAIYSLYKYILLNELLvaDPSgnakstqndDKMVIKVDAMIAKLLppaaePRKYLKLTELPQVV 298
Cdd:pfam02201   6 SPELAELLGEEELSRPEVVKALWEYIKENNLQ--DPE---------DKREIICDEKLKKLF-----GGDRVKFFEMPKLL 69


                  ....
gi 45184883   299 NAHI 302
Cdd:pfam02201  70 SPHL 73
 
Name Accession Description Interval E-value
SWIB_like cd10568
SWIB domain found in the 60 kda subunit of the ATP-dependent SWI/SNF chromatin-remodeling ...
 218-302 1.78e-11

SWIB domain found in the 60 kda subunit of the ATP-dependent SWI/SNF chromatin-remodeling complexes and similar proteins; SWIB domain is a conserved region found within proteins in the SWI/SNF family of complexes. SWI/SNF complex proteins display helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The mammalian complexes are made up of 9-12 proteins called BAFs (BRG1-associated factors), among which the BAF60 subunit serves as a key link between the core complexes and specific transcriptional factors. The BAF60 subunit have at least three members: BAF60a, which is ubiquitous, BAF60b and BAF60c, which are expressed in muscle and pancreatic tissues, respectively. The family also includes Saccharomyces cerevisiae transcription regulatory protein SNF12 and remodel the structure of chromatin complex subunit 6 (RSC6), and Schizosaccharomyces pombe SWI/SNF and RSC complexes subunit SSR3. SNF12, also termed 73-kDa subunit of the SWI/SNF transcriptional regulatory complex, or SWI/SNF complex component SWP73, is involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). RSC6 and SSR3 are components of the RSC, which is involved in transcription regulation and nucleosome positioning. RSC6 is essential for mitotic growth and suppresses formamide sensitivity of the RSC8 mutants.


Pssm-ID: 349490 [Multi-domain]  Cd Length: 69  Bit Score: 59.47  E-value: 1.78e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45184883 218 YSDALAFIIGVARGTVHEAIYSLYKYILLNELLvaDPsgnakstqnDDKMVIKVDAMIAKLLPPaaeprKYLKLTELPQV 297
Cdd:cd10568   1 LSPALAQLLGIKEGTRPNIIYALWQYIKLNKLQ--DP---------EDRRLINCDEALKQLFGV-----ERFKFSELPEL 64


                ....*
gi 45184883 298 VNAHI 302
Cdd:cd10568  65 LNPHL 69
SWIB pfam02201
SWIB/MDM2 domain; This family includes the SWIB domain and the MDM2 domain. The p53-associated ...
 219-302 7.03e-05

SWIB/MDM2 domain; This family includes the SWIB domain and the MDM2 domain. The p53-associated protein (MDM2) is an inhibitor of the p53 tumour suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. This family contains the p53 binding domain of MDM2.


Pssm-ID: 460488 [Multi-domain]  Cd Length: 73  Bit Score: 40.93  E-value: 7.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45184883   219 SDALAFIIGVARGTVHEAIYSLYKYILLNELLvaDPSgnakstqndDKMVIKVDAMIAKLLppaaePRKYLKLTELPQVV 298
Cdd:pfam02201   6 SPELAELLGEEELSRPEVVKALWEYIKENNLQ--DPE---------DKREIICDEKLKKLF-----GGDRVKFFEMPKLL 69


                  ....
gi 45184883   299 NAHI 302
Cdd:pfam02201  70 SPHL 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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