|
Name |
Accession |
Description |
Interval |
E-value |
| UCH |
pfam00443 |
Ubiquitin carboxyl-terminal hydrolase; |
44-329 |
2.52e-68 |
|
Ubiquitin carboxyl-terminal hydrolase;
Pssm-ID: 425685 [Multi-domain] Cd Length: 310 Bit Score: 216.15 E-value: 2.52e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 44 TGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQ--NDCSEVATAFAYLMTDMWLGDSD-CVSPEIFWSALGNLY 120
Cdd:pfam00443 1 TGLVNLGNTCYMNSVLQSLFSIPPFRDYLLRISPLSEDSryNKDINLLCALRDLFKALQKNSKSsSVSPKMFKKSLGKLN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 121 PAFTKKMQQDAQEFLICVLNELHEALKKYHysrrrsyekgstqrccrkwITTETSIITQLFEEQLNYSIVCLKCEKCTYK 200
Cdd:pfam00443 81 PDFSGYKQQDAQEFLLFLLDGLHEDLNGNH-------------------STENESLITDLFRGQLKSRLKCLSCGEVSET 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 201 NEVFTVFSLPIPSK----YECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRFDIQGTTK 276
Cdd:pfam00443 142 FEPFSDLSLPIPGDsaelKTASLQICFLQFSKLEELDDEEKYYCDKCGCKQDAIKQLKISRLPPVLIIHLKRFSYNRSTW 221
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 291290970 277 RKLRTDIHYPLTnLDLTPYICSIFRKY----PKYNLCAVVNHFGDLDGGHYTAFCKN 329
Cdd:pfam00443 222 EKLNTEVEFPLE-LDLSRYLAEELKPKtnnlQDYRLVAVVVHSGSLSSGHYIAYIKA 277
|
|
| Peptidase_C19R |
cd02674 |
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-333 |
4.40e-64 |
|
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239139 [Multi-domain] Cd Length: 230 Bit Score: 202.52 E-value: 4.40e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 45 GLWNLGNTCCVNAISQCLCSilplveyfltgkyitalqndcsevatafaylmtdmwlgdsdcvspeifwsalgnlypaft 124
Cdd:cd02674 1 GLRNLGNTCYMNSILQCLSA------------------------------------------------------------ 20
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 125 kkMQQDAQEFLICVLNELHealkkyhysrrrsyekgstqrccrkwittetSIITQLFEEQLNYSIVCLKCEKCTYKNEVF 204
Cdd:cd02674 21 --DQQDAQEFLLFLLDGLH-------------------------------SIIVDLFQGQLKSRLTCLTCGKTSTTFEPF 67
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 205 TVFSLPIPSKY----ECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRFDIQGTTKRKLR 280
Cdd:cd02674 68 TYLSLPIPSGSgdapKVTLEDCLRLFTKEETLDGDNAWKCPKCKKKRKATKKLTISRLPKVLIIHLKRFSFSRGSTRKLT 147
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 291290970 281 TDIHYPLTNLDLTPY-ICSIFRKYPKYNLCAVVNHFGDLDGGHYTAFCKNSVTQ 333
Cdd:cd02674 148 TPVTFPLNDLDLTPYvDTRSFTGPFKYDLYAVVNHYGSLNGGHYTAYCKNNETN 201
|
|
| Peptidase_C19 |
cd02257 |
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ... |
45-333 |
1.95e-47 |
|
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239072 [Multi-domain] Cd Length: 255 Bit Score: 160.73 E-value: 1.95e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 45 GLWNLGNTCCVNAISQCLCSilplveyfltgkyitalqndcsevatafaylmtdmwlgdsdcvspeifwsalgnlypaft 124
Cdd:cd02257 1 GLNNLGNTCYLNSVLQALFS------------------------------------------------------------ 20
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 125 kkMQQDAQEFLICVLNELHEALKKYHYSRrrsyekgstqrccrKWITTETSIITQLFEEQLNYSIVCLKCEKCTYKNEVF 204
Cdd:cd02257 21 --EQQDAHEFLLFLLDKLHEELKKSSKRT--------------SDSSSLKSLIHDLFGGKLESTIVCLECGHESVSTEPE 84
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 205 TVFSLPIP--SKYECSLRDCLQCFFQQDALTWNNEIHCSfCETKQETAVRASISKAPKIIIFHLKRFDIQGT-TKRKLRT 281
Cdd:cd02257 85 LFLSLPLPvkGLPQVSLEDCLEKFFKEEILEGDNCYKCE-KKKKQEATKRLKIKKLPPVLIIHLKRFSFNEDgTKEKLNT 163
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 291290970 282 DIHYPLTnLDLTPYICSIFRKYP------KYNLCAVVNHFGDL-DGGHYTAFCKNSVTQ 333
Cdd:cd02257 164 KVSFPLE-LDLSPYLSEGEKDSDsdngsyKYELVAVVVHSGTSaDSGHYVAYVKDPSDG 221
|
|
| Peptidase_C19E |
cd02661 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
44-330 |
3.76e-37 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239126 [Multi-domain] Cd Length: 304 Bit Score: 135.10 E-value: 3.76e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 44 TGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYitalQNDCSEVA----TAFAYLMTDMWLGDSDCVSPEIFWSALGNL 119
Cdd:cd02661 2 AGLQNLGNTCFLNSVLQCLTHTPPLANYLLSREH----SKDCCNEGfcmmCALEAHVERALASSGPGSAPRIFSSNLKQI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 120 YPAFTKKMQQDAQEFLICVLNELHEAlkkyhYSRRRSYEKGSTQRccrkwiTTETSIITQLFEEQLNYSIVCLKCEKCTY 199
Cdd:cd02661 78 SKHFRIGRQEDAHEFLRYLLDAMQKA-----CLDRFKKLKAVDPS------SQETTLVQQIFGGYLRSQVKCLNCKHVSN 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 200 KNEVFTVFSLPIPSkyECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRFdiQGTTKRKL 279
Cdd:cd02661 147 TYDPFLDLSLDIKG--ADSLEDALEQFTKPEQLDGENKYKCERCKKKVKASKQLTIHRAPNVLTIHLKRF--SNFRGGKI 222
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 291290970 280 RTDIHYPLTnLDLTPYICSIFRKYPKYNLCAVVNHFG-DLDGGHYTAFCKNS 330
Cdd:cd02661 223 NKQISFPET-LDLSPYMSQPNDGPLKYKLYAVLVHSGfSPHSGHYYCYVKSS 273
|
|
| Peptidase_C19G |
cd02663 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-328 |
1.52e-36 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239128 [Multi-domain] Cd Length: 300 Bit Score: 133.20 E-value: 1.52e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 45 GLWNLGNTCCVNAISQCLcsilplveYFLTgkYITALqndcsevATAFAYLMTDMWLGDSdcVSPEIFWSALGNLYPAFT 124
Cdd:cd02663 1 GLENFGNTCYCNSVLQAL--------YFEN--LLTCL-------KDLFESISEQKKRTGV--ISPKKFITRLKRENELFD 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 125 KKMQQDAQEFLICVLNELHEALKKYHYSRRRSYEKGSTQRCcrkwiTTETSIITQLFEEQLNYSIVCLKCEKCTYKNEVF 204
Cdd:cd02663 62 NYMHQDAHEFLNFLLNEIAEILDAERKAEKANRKLNNNNNA-----EPQPTWVHEIFQGILTNETRCLTCETVSSRDETF 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 205 TVFSLPIPSkyECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRFDIQGTTKR--KLRTD 282
Cdd:cd02663 137 LDLSIDVEQ--NTSITSCLRQFSATETLCGRNKFYCDECCSLQEAEKRMKIKKLPKILALHLKRFKYDEQLNRyiKLFYR 214
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 291290970 283 IHYPLTnldLTPYICSIFRKYP--KYNLCAVVNHFGdlDG---GHYTAFCK 328
Cdd:cd02663 215 VVFPLE---LRLFNTTDDAENPdrLYELVAVVVHIG--GGpnhGHYVSIVK 260
|
|
| Peptidase_C19D |
cd02660 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-333 |
9.66e-35 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239125 [Multi-domain] Cd Length: 328 Bit Score: 129.41 E-value: 9.66e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 45 GLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYitALQNDCSEVATAFAYLMTDMW--LGDSDCVSPEIF-------WSA 115
Cdd:cd02660 2 GLINLGATCFMNVILQALLHNPLLRNYFLSDRH--SCTCLSCSPNSCLSCAMDEIFqeFYYSGDRSPYGPinllylsWKH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 116 LGNLypAFTKkmQQDAQEFLICVLNELHEALKkyhysrRRSYEKGSTQRCcrkwitteTSIITQLFEEQLNYSIVCLKCE 195
Cdd:cd02660 80 SRNL--AGYS--QQDAHEFFQFLLDQLHTHYG------GDKNEANDESHC--------NCIIHQTFSGSLQSSVTCQRCG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 196 KCTYKNEVFTVFSLPIPSKYECS-------------LRDCLQCFFQQDALTwNNEIHCSFCETKQETAVRASISKAPKII 262
Cdd:cd02660 142 GVSTTVDPFLDLSLDIPNKSTPSwalgesgvsgtptLSDCLDRFTRPEKLG-DFAYKCSGCGSTQEATKQLSIKKLPPVL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 263 IFHLKRFD-IQGTTKRKLRTDIHYPLTnLDLTPYICSIFRKYP---------KYNLCAVVNHFGDLDGGHYTAFCKNSVT 332
Cdd:cd02660 221 CFQLKRFEhSLNKTSRKIDTYVQFPLE-LNMTPYTSSSIGDTQdsnsldpdyTYDLFAVVVHKGTLDTGHYTAYCRQGDG 299
|
.
gi 291290970 333 Q 333
Cdd:cd02660 300 Q 300
|
|
| Peptidase_C19K |
cd02667 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-328 |
7.96e-29 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239132 [Multi-domain] Cd Length: 279 Bit Score: 112.09 E-value: 7.96e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 45 GLWNLGNTCCVNAISQCLCSILPLVEYFLTgkyitalqndcsevatafaylmtdmwlgdsdcvSPEIFWSALGNLYPAFT 124
Cdd:cd02667 1 GLSNLGNTCFFNAVMQNLSQTPALRELLSE---------------------------------TPKELFSQVCRKAPQFK 47
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 125 KKMQQDAQEFLICVLNELhealkkyhysrrrsyekgstqrccrkwitteTSIITQLFEEQLNYSIVCLKCEKCTYKNEVF 204
Cdd:cd02667 48 GYQQQDSHELLRYLLDGL-------------------------------RTFIDSIFGGELTSTIMCESCGTVSLVYEPF 96
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 205 TVFSLPI--PSKYECSLRDCLQCFFQQDALTWNNEIHCSFCetkQETAVRASISKAPKIIIFHLKRFdiQGTTK---RKL 279
Cdd:cd02667 97 LDLSLPRsdEIKSECSIESCLKQFTEVEILEGNNKFACENC---TKAKKQYLISKLPPVLVIHLKRF--QQPRSanlRKV 171
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 291290970 280 RTDIHYPLTnLDLTPYI---CSIFR--KYPKYNLCAVVNHFGDLDGGHYTAFCK 328
Cdd:cd02667 172 SRHVSFPEI-LDLAPFCdpkCNSSEdkSSVLYRLYGVVEHSGTMRSGHYVAYVK 224
|
|
| peptidase_C19C |
cd02659 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-328 |
1.45e-26 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239124 [Multi-domain] Cd Length: 334 Bit Score: 107.34 E-value: 1.45e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 45 GLWNLGNTCCVNAISQCLCSILPLVEYFLTGKyITALQNDCSEVATAFAYLMTDMWLGDSDCVSPEIFWSALGNLYPAFT 124
Cdd:cd02659 4 GLKNQGATCYMNSLLQQLYMTPEFRNAVYSIP-PTEDDDDNKSVPLALQRLFLFLQLSESPVKTTELTDKTRSFGWDSLN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 125 KKMQQDAQEFLICVLNELHEALKKyhysrrrsyekgstqrccrkwiTTETSIITQLFEEQLNYSIVCLKCEKCTYKNEVF 204
Cdd:cd02659 83 TFEQHDVQEFFRVLFDKLEEKLKG----------------------TGQEGLIKNLFGGKLVNYIICKECPHESEREEYF 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 205 TVFSLPIPSKYecSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRF--DIQGTTKRKLRTD 282
Cdd:cd02659 141 LDLQVAVKGKK--NLEESLDAYVQGETLEGDNKYFCEKCGKKVDAEKGVCFKKLPPVLTLQLKRFefDFETMMRIKINDR 218
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 291290970 283 IHYPLTnLDLTPYI-----------CSIFRKYPKYNLCAVVNHFGDLDGGHYTAFCK 328
Cdd:cd02659 219 FEFPLE-LDMEPYTekglakkegdsEKKDSESYIYELHGVLVHSGDAHGGHYYSYIK 274
|
|
| Peptidase_C19L |
cd02668 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-332 |
1.84e-26 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239133 [Multi-domain] Cd Length: 324 Bit Score: 106.74 E-value: 1.84e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 45 GLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQNDCSEVATAF---------AYLMTDMWLGDSDCVSPEIFWSA 115
Cdd:cd02668 1 GLKNLGATCYVNSFLQLWFMNLEFRKAVYECNSTEDAELKNMPPDKPHepqtiidqlQLIFAQLQFGNRSVVDPSGFVKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 116 LGnlypaFTKKMQQDAQEFLICVLNELHEALKKYHYSRRRSyekgstqrccrkwittetsIITQLFEEQLNYSIVCLKCE 195
Cdd:cd02668 81 LG-----LDTGQQQDAQEFSKLFLSLLEAKLSKSKNPDLKN-------------------IVQDLFRGEYSYVTQCSKCG 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 196 KCTYKNEVFtvFSLPIPSKYECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKR--FDIQG 273
Cdd:cd02668 137 RESSLPSKF--YELELQLKGHKTLEECIDEFLKEEQLTGDNQYFCESCNSKTDATRRIRLTTLPPTLNFQLLRfvFDRKT 214
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 274 TTKRKLRTDIHYPLTnLDLTPYICSIFRKYPKYNLCAVVNHFG-DLDGGHYTAFCKNSVT 332
Cdd:cd02668 215 GAKKKLNASISFPEI-LDMGEYLAESDEGSYVYELSGVLIHQGvSAYSGHYIAHIKDEQT 273
|
|
| UBP12 |
COG5560 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
42-214 |
7.31e-24 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227847 [Multi-domain] Cd Length: 823 Bit Score: 102.27 E-value: 7.31e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 42 GVTGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYitalQNDCSE---------VATAFAYLMTDMWLGDSDCVSPEIF 112
Cdd:COG5560 264 GTCGLRNLGNTCYMNSALQCLMHTWELRDYFLSDEY----EESINEenplgmhgsVASAYADLIKQLYDGNLHAFTPSGF 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 113 WSALGNLYPAFTKKMQQDAQEFLICVLNELHEAL----KKYHYSRRRSYE------KGSTQRCCRKWITTETSIITQLFE 182
Cdd:COG5560 340 KKTIGSFNEEFSGYDQQDSQEFIAFLLDGLHEDLnriiKKPYTSKPDLSPgddvvvKKKAKECWWEHLKRNDSIITDLFQ 419
|
170 180 190
....*....|....*....|....*....|..
gi 291290970 183 EQLNYSIVCLKCEKCTYKNEVFTVFSLPIPSK 214
Cdd:COG5560 420 GMYKSTLTCPGCGSVSITFDPFMDLTLPLPVS 451
|
|
| UBP12 |
COG5560 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
168-333 |
1.62e-21 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227847 [Multi-domain] Cd Length: 823 Bit Score: 95.34 E-value: 1.62e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 168 KWITTETSIITQLF-----EEQLNYS----IVCLKCEKCTykNEVFTVFSLPIPSKYEC-----SLRDCLQCFFQQDALT 233
Cdd:COG5560 614 SWLKLETEIDTKREeqveeEGQMNFNdavvISCEWEEKRY--LSLFSYDPLWTIREIGAaertiTLQDCLNEFSKPEQLG 691
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 234 WNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRFDIQGTTKRKLRTDIHYPLTNLDLTPYICSIFRKYPKYNLCAVVN 313
Cdd:COG5560 692 LSDSWYCPGCKEFRQASKQMELWRLPMILIIHLKRFSSVRSFRDKIDDLVEYPIDDLDLSGVEYMVDDPRLIYDLYAVDN 771
|
170 180
....*....|....*....|
gi 291290970 314 HFGDLDGGHYTAFCKNSVTQ 333
Cdd:COG5560 772 HYGGLSGGHYTAYARNFANN 791
|
|
| Peptidase_C19A |
cd02657 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-330 |
8.05e-21 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239122 [Multi-domain] Cd Length: 305 Bit Score: 90.85 E-value: 8.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 45 GLWNLGNTCCVNAISQCLCSILPLVEYFL--TGKYITALQNdCSEVATAFAYLMTDMwLGDSDCVSPEIFWSALGNLYPA 122
Cdd:cd02657 1 GLTNLGNTCYLNSTLQCLRSVPELRDALKnyNPARRGANQS-SDNLTNALRDLFDTM-DKKQEPVPPIEFLQLLRMAFPQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 123 FTKK------MQQDAQEFLICVLNELhealkkyhysrRRSYEKGStqrccrkwitTETSIITQLFEEQLNYSIVCLKCEK 196
Cdd:cd02657 79 FAEKqnqggyAQQDAEECWSQLLSVL-----------SQKLPGAG----------SKGSFIDQLFGIELETKMKCTESPD 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 197 C-TYKNEVFTVFSLPIPSKYECS-LRDCLqcffqQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRF----D 270
Cdd:cd02657 138 EeEVSTESEYKLQCHISITTEVNyLQDGL-----KKGLEEEIEKHSPTLGRDAIYTKTSRISRLPKYLTVQFVRFfwkrD 212
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 291290970 271 IQgtTKRKLRTDIHYPLtNLDLTPYiCSifrKYPKYNLCAVVNHFG-DLDGGHYTAFCKNS 330
Cdd:cd02657 213 IQ--KKAKILRKVKFPF-ELDLYEL-CT---PSGYYELVAVITHQGrSADSGHYVAWVRRK 266
|
|
| Peptidase_C19B |
cd02658 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-328 |
2.83e-20 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239123 [Multi-domain] Cd Length: 311 Bit Score: 89.30 E-value: 2.83e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 45 GLWNLGNTCCVNAISQCLCSILPLVEYF--LTGKYITALQNDCSEVATAFAYLMTDMWLGDS--------------DCVS 108
Cdd:cd02658 1 GLRNLGNSCYLNSVLQVLFSIPSFQWRYddLENKFPSDVVDPANDLNCQLIKLADGLLSGRYskpaslksendpyqVGIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 109 PEIFWSALGNLYPAFTKKMQQDAQEFLICVLNELHEALKKyhysrrrsyekgstqrccrkwitTETSIITQLFEEQLNYS 188
Cdd:cd02658 81 PSMFKALIGKGHPEFSTMRQQDALEFLLHLIDKLDRESFK-----------------------NLGLNPNDLFKFMIEDR 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 189 IVCLKCEKCTYKNEVFTVFSLPIP------------SKYECSLRDCLQCFFQQDALtwnnEIHCSFCETKQETAVRASIS 256
Cdd:cd02658 138 LECLSCKKVKYTSELSEILSLPVPkdeatekeegelVYEPVPLEDCLKAYFAPETI----EDFCSTCKEKTTATKTTGFK 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 291290970 257 KAPKIIIFHLKRFDI-QGTTKRKLRTDIHYPltnLDLTPyicsifrkyPKYNLCAVVNHFG-DLDGGHYTAFCK 328
Cdd:cd02658 214 TFPDYLVINMKRFQLlENWVPKKLDVPIDVP---EELGP---------GKYELIAFISHKGtSVHSGHYVAHIK 275
|
|
| Peptidase_C19O |
cd02671 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-328 |
1.06e-18 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239136 [Multi-domain] Cd Length: 332 Bit Score: 85.33 E-value: 1.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 45 GLWNLGNTCCVNAISQCLCsilpLVEYFLTGkyITALQNDCSEVATAFAYLMTDMWLGDSDCVS--PEIFWSALGNLYPA 122
Cdd:cd02671 26 GLNNLGNTCYLNSVLQVLY----FCPGFKHG--LKHLVSLISSVEQLQSSFLLNPEKYNDELANqaPRRLLNALREVNPM 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 123 FTKKMQQDAQEFLICVLNELHEALKKyhysrrrsyekgstqrccrkwittetsiitqLFEEQLNYSIVCLKCEKCTYKNE 202
Cdd:cd02671 100 YEGYLQHDAQEVLQCILGNIQELVEK-------------------------------DFQGQLVLRTRCLECETFTERRE 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 203 VFTVFSLPIPS----------------KYECS-LRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFH 265
Cdd:cd02671 149 DFQDISVPVQEselskseesseispdpKTEMKtLKWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKLPEVITIH 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 266 LKRFDIQGTTK------RKLRTdihYPLTNLDLTPYICSIFRKYPKYNLCAVVNHFG-DLDGGHYTAFCK 328
Cdd:cd02671 229 LKCFAANGSEFdcygglSKVNT---PLLTPLKLSLEEWSTKPKNDVYRLFAVVMHSGaTISSGHYTAYVR 295
|
|
| Peptidase_C19M |
cd02669 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
36-316 |
2.26e-17 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239134 [Multi-domain] Cd Length: 440 Bit Score: 82.37 E-value: 2.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 36 NQPHFQGVTGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQNDCSEVATAFAYLMTDMWlgdsDC------VSP 109
Cdd:cd02669 112 GKPYLPGFVGLNNIKNNDYANVIIQALSHVKPIRNFFLLYENYENIKDRKSELVKRLSELIRKIW----NPrnfkghVSP 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 110 EIFWSALGNLYPA-FTKKMQQDAQEFLICVLNELHEALKKYHYSRRRSYekgstQRCCRKWITTETSIITQLfEEQLNYS 188
Cdd:cd02669 188 HELLQAVSKVSKKkFSITEQSDPVEFLSWLLNTLHKDLGGSKKPNSSII-----HDCFQGKVQIETQKIKPH-AEEEGSK 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 189 IVCLKCEKCTYKNEV-FTVFS--LPIPSKYECSLRDCL--QCFFQQdALTWNNEIHCSfcETKqETAVRASISKAPKIII 263
Cdd:cd02669 262 DKFFKDSRVKKTSVSpFLLLTldLPPPPLFKDGNEENIipQVPLKQ-LLKKYDGKTET--ELK-DSLKRYLISRLPKYLI 337
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 291290970 264 FHLKRFDIQGTTKRKLRTDIHYPLTNLDLTPYICSIFR---KYPKYNLCAVVNHFG 316
Cdd:cd02669 338 FHIKRFSKNNFFKEKNPTIVNFPIKNLDLSDYVHFDKPslnLSTKYNLVANIVHEG 393
|
|
| Peptidase_C19H |
cd02664 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-331 |
2.57e-16 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239129 [Multi-domain] Cd Length: 327 Bit Score: 78.30 E-value: 2.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 45 GLWNLGNTCCVNAISQCLCSILPLVEYFLTGKyiTALQNDCSEVATA----FAYLMTDMwlGDSDCVsPEIFWSAlgNLY 120
Cdd:cd02664 1 GLINLGNTCYMNSVLQALFMAKDFRRQVLSLN--LPRLGDSQSVMKKlqllQAHLMHTQ--RRAEAP-PDYFLEA--SRP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 121 PAFTKKMQQDAQEFLICVLNELHealkkyhysrrrsyekgstqrccrkwittetSIITQLFEEQLNYSIVCLKCEKCTYK 200
Cdd:cd02664 74 PWFTPGSQQDCSEYLRYLLDRLH-------------------------------TLIEKMFGGKLSTTIRCLNCNSTSAR 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 201 NEVFTVFSLPIPSkyecsLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRF--DIQGTTKRK 278
Cdd:cd02664 123 TERFRDLDLSFPS-----VQDLLNYFLSPEKLTGDNQYYCEKCASLQDAEKEMKVTGAPEYLILTLLRFsyDQKTHVREK 197
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 291290970 279 LRTDIHYPLTnLDLTPYICSIFRKYPK-------------------YNLCAVVNHFG-DLDGGHYTAFCKNSV 331
Cdd:cd02664 198 IMDNVSINEV-LSLPVRVESKSSESPLekkeeesgddgelvtrqvhYRLYAVVVHSGySSESGHYFTYARDQT 269
|
|
| Peptidase_C19F |
cd02662 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
45-332 |
1.38e-14 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239127 [Multi-domain] Cd Length: 240 Bit Score: 72.01 E-value: 1.38e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 45 GLWNLGNTCCVNAISQCLCSILPLVEYfltgkyitaLQNdcsevatafaylmtdmwlgdsdcvspeifwsalgnlypaFT 124
Cdd:cd02662 1 GLVNLGNTCFMNSVLQALASLPSLIEY---------LEE---------------------------------------FL 32
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 125 KkmQQDAQEFLICVLNELHealkkyhysrrrsyekgstqrccrkwittetSIITQLFEEQLNYSIVCLKC-EKCTYKNEV 203
Cdd:cd02662 33 E--QQDAHELFQVLLETLE-------------------------------QLLKFPFDGLLASRIVCLQCgESSKVRYES 79
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 204 FTVFSLPIPSK---YECSLRDCLQCFFQQDALtwnNEIHCSFCETKqetavrasISKAPKIIIFHLKR--FDIQGT-TKR 277
Cdd:cd02662 80 FTMLSLPVPNQssgSGTTLEHCLDDFLSTEII---DDYKCDRCQTV--------IVRLPQILCIHLSRsvFDGRGTsTKN 148
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 291290970 278 KLRtdIHYPLTnldLTPYicsifrkypKYNLCAVVNHFGDLDGGHYTAFCKNSVT 332
Cdd:cd02662 149 SCK--VSFPER---LPKV---------LYRLRAVVVHYGSHSSGHYVCYRRKPLF 189
|
|
| COG5533 |
COG5533 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
45-328 |
3.07e-14 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 444284 [Multi-domain] Cd Length: 284 Bit Score: 71.76 E-value: 3.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 45 GLWNLGNTCCVNAISQCLCSILPLVEYFLT--GKYITALQN---DCSEVAT--AFAYLMTDMWLGDSDCVSPEifwsalg 117
Cdd:COG5533 1 GLPNLGNTCFMNSVLQILALYLPKLDELLDdlSKELKVLKNvirKPEPDLNqeEALKLFTALWSSKEHKVGWI------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 118 nlypaFTKKMQQDAQEFLICVLNELhEALKKYHYSRRrsyekgstqrccrKWITTETsiitqlfeeqlnysivclkcEKC 197
Cdd:COG5533 74 -----PPMGSQEDAHELLGKLLDEL-KLDLVNSFTIR-------------IFKTTKD--------------------KKK 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 198 TYKNEVFTVF-SLPIPSKYECSlrDCLQCFFQQDALTWNNEIHCSFCETKQETAV-----RASISKAPKIIIFHLKRFDI 271
Cdd:COG5533 115 TSTGDWFDIIiELPDQTWVNNL--KTLQEFIDNMEELVDDETGVKAKENEELEVQakqeyEVSFVKLPKILTIQLKRFAN 192
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 291290970 272 QGTtKRKLRTDIHYPLtNLDLTPYICSIFRKYPKYNLCAVVNHFGDLDGGHYTAFCK 328
Cdd:COG5533 193 LGG-NQKIDTEVDEKF-ELPVKHDQILNIVKETYYDLVGFVLHQGSLEGGHYIAYVK 247
|
|
| COG5077 |
COG5077 |
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ... |
42-331 |
3.88e-09 |
|
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227409 [Multi-domain] Cd Length: 1089 Bit Score: 57.96 E-value: 3.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 42 GVTGLWNLGNTCCVNAISQCLCSIlplvEYFLTGKYITALQNDCS--EVATAFAYLMTDMWLGDSDCVSPEIFWSalgNL 119
Cdd:COG5077 192 GYVGLRNQGATCYMNSLLQSLFFI----AKFRKDVYGIPTDHPRGrdSVALALQRLFYNLQTGEEPVDTTELTRS---FG 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 120 YPAFTKKMQQDAQEFLICVLNELHEALKKyhysrrrsyekgstqrccrkwiTTETSIITQLFEEQLNYSIVCLKCEKCTY 199
Cdd:COG5077 265 WDSDDSFMQHDIQEFNRVLQDNLEKSMRG----------------------TVVENALNGIFVGKMKSYIKCVNVNYESA 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 200 KNEVFtvFSLPIPSKYECSLRDCLQCFFQQDALTWNNeihCSFCETK--QETAVRASISKAPKIIIFHLKRFDIQGTTKR 277
Cdd:COG5077 323 RVEDF--WDIQLNVKGMKNLQESFRRYIQVETLDGDN---RYNAEKHglQDAKKGVIFESLPPVLHLQLKRFEYDFERDM 397
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 278 --KLRTDIHYPLTnLDLTPYICSIFRKYPK----YNLCAVVNHFGDLDGGHYTAFCKNSV 331
Cdd:COG5077 398 mvKINDRYEFPLE-IDLLPFLDRDADKSENsdavYVLYGVLVHSGDLHEGHYYALLKPEK 456
|
|
| Peptidase_C19J |
cd02666 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
44-323 |
1.70e-08 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239131 [Multi-domain] Cd Length: 343 Bit Score: 55.19 E-value: 1.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 44 TGLWNLGNTCCVNAISQCLCSILPLVEYFLT-GKYITALQNDCSE---------------VATAFAY----LMTDMWLGD 103
Cdd:cd02666 2 AGLDNIGNTCYLNSLLQYFFTIKPLRDLVLNfDESKAELASDYPTerriggrevsrselqRSNQFVYelrsLFNDLIHSN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 104 SDCVSPEifwSALGNLypAFTkkmQQDAQEFLICVLNELHEALKKYHYSRRRSYEKGSTQrccrkwittETSIITQLFEE 183
Cdd:cd02666 82 TRSVTPS---KELAYL--ALR---QQDVTECIDNVLFQLEVALEPISNAFAGPDTEDDKE---------QSDLIKRLFSG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 184 QLNYSIVCLKCE---KCTYKNEVFtvFSLPIPSKYE----------CSLRDCLQCFFQQDALT-----WNNEIHCSFCET 245
Cdd:cd02666 145 KTKQQLVPESMGnqpSVRTKTERF--LSLLVDVGKKgreivvllepKDLYDALDRYFDYDSLTklpqrSQVQAQLAQPLQ 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 246 KQETAVR----ASISKAPKIIIFHLKRfdiqgtTKRKLRTDIHYPLTNLDLTpyICSIF---RKYPkYNLCAVVNHFGDL 318
Cdd:cd02666 223 RELISMDryelPSSIDDIDELIREAIQ------SESSLVRQAQNELAELKHE--IEKQFddlKSYG-YRLHAVFIHRGEA 293
|
....*
gi 291290970 319 DGGHY 323
Cdd:cd02666 294 SSGHY 298
|
|
| Peptidase_C19Q |
cd02673 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
114-330 |
8.36e-08 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239138 [Multi-domain] Cd Length: 245 Bit Score: 52.53 E-value: 8.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 114 SALGNLYPAFTKKMQQDAQEFLICVLNELHEALKKYHYSRRRSYEKGSTQRCCRKW-ITTETSIitqlfeeqlnysiVCL 192
Cdd:cd02673 19 SSIGKINTEFDNDDQQDAHEFLLTLLEAIDDIMQVNRTNVPPSNIEIKRLNPLEAFkYTIESSY-------------VCI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 193 KCEKCTYKNEVFTVFSLPIPSKYECSLRDCLQCFFqqdalTWNN-EIHCSFCETkQETAVRASISKAPKIIIFHLKRFDI 271
Cdd:cd02673 86 GCSFEENVSDVGNFLDVSMIDNKLDIDELLISNFK-----TWSPiEKDCSSCKC-ESAISSERIMTFPECLSINLKRYKL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 291290970 272 QGTTKRKLRTDihypltnldltpyiCSIFRKY----PKYNLCAVVNHFGDL-DGGHYTAFCKNS 330
Cdd:cd02673 160 RIATSDYLKKN--------------EEIMKKYcgtdAKYSLVAVICHLGESpYDGHYIAYTKEL 209
|
|
| Peptidase_C19I |
cd02665 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
200-326 |
7.55e-04 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239130 [Multi-domain] Cd Length: 228 Bit Score: 40.23 E-value: 7.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291290970 200 KNEVFtvFSLPIPSKYECSLRDCLQcffqqdALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRFDIQGTTKRKL 279
Cdd:cd02665 78 NCETF--GQYPLQVNGYGNLHECLE------AAMFEGEVELLPSDHSVKSGQERWFTELPPVLTFELSRFEFNQGRPEKI 149
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90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 291290970 280 RTDIHYPltnldltpyicSIFRKYPkYNLCAVVNHFGDLDGGHYTAF 326
Cdd:cd02665 150 HDKLEFP-----------QIIQQVP-YELHAVLVHEGQANAGHYWAY 184
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