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Conserved domains on  [gi|45430035|ref|NP_991375|]
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CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 precursor [Bos taurus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 116-321 2.17e-137

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467710  Cd Length: 204  Bit Score: 387.87  E-value: 2.17e-137
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 116 KCRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMRLFYPESAHFNPKVEDNPDTLLVLVAFKAM 195
Cdd:cd23982   1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 196 DFHWIESILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFYMEIAADKLLSLPIHQphKIKQKPTTGLLAITLALHLCDL 275
Cdd:cd23982  81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQR--KKKQKPTTGLLAITLALHLCDE 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 45430035 276 VHIAGFGYPDAHQKKQSIHYYEYITLKSMMWSGHNVSQEALAIKRM 321
Cdd:cd23982 159 VHIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
 
Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 116-321 2.17e-137

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 387.87  E-value: 2.17e-137
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 116 KCRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMRLFYPESAHFNPKVEDNPDTLLVLVAFKAM 195
Cdd:cd23982   1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 196 DFHWIESILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFYMEIAADKLLSLPIHQphKIKQKPTTGLLAITLALHLCDL 275
Cdd:cd23982  81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQR--KKKQKPTTGLLAITLALHLCDE 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 45430035 276 VHIAGFGYPDAHQKKQSIHYYEYITLKSMMWSGHNVSQEALAIKRM 321
Cdd:cd23982 159 VHIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 84-326 8.50e-66

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 207.85  E-value: 8.50e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035    84 YELPYgtKGSEDLLLRVLAITSysipesIQSLKCRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKT 163
Cdd:pfam00777  18 WWLPF--TVTEELLELLPKVSP------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035   164 TMRLFYPESA---HFNPKVEDN---PDTLLVLVAFKAMDFHWIESILSdKKRVRKGFWKQP---PLIWDVNPKQIRILNP 234
Cdd:pfam00777  90 TLRTMNPESAidsKYGNLGFSHprdPFVEFVLVPFKGRDLLWLPAFLT-KGNVSRSLRVLYtlkEVKIPVDPDKVLFLHP 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035   235 FYMEIAADKLLSLPIHQPHkikqKPTTGLLAITLALHLCDLVHIAGFGYPDaHQKKQSIHYYEYITLKSMMWSG-HNVSQ 313
Cdd:pfam00777 169 DFLRYVANFWLRSHGLKGR----RPSTGLLMLSLALHLCDEVSLYGFGPFL-DSRGNSHHYYDNVLMKKGGFYGvHDMPF 243

                         250
                  ....*....|...
gi 45430035   314 EALAIKRMLEIGA 326
Cdd:pfam00777 244 EFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 116-321 2.17e-137

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 387.87  E-value: 2.17e-137
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 116 KCRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMRLFYPESAHFNPKVEDNPDTLLVLVAFKAM 195
Cdd:cd23982   1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 196 DFHWIESILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFYMEIAADKLLSLPIHQphKIKQKPTTGLLAITLALHLCDL 275
Cdd:cd23982  81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQR--KKKQKPTTGLLAITLALHLCDE 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 45430035 276 VHIAGFGYPDAHQKKQSIHYYEYITLKSMMWSGHNVSQEALAIKRM 321
Cdd:cd23982 159 VHIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 116-321 1.24e-105

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 307.30  E-value: 1.24e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 116 KCRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMRLFYPESAHFNPKvEDNPDTLLVLVAFKAM 195
Cdd:cd23967   1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPE-EYDSDWLLVLVPFKSM 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 196 DFHWIESILSDKKRV-RKGFWKQPPLIWDVNPKQIRILNPFYMEIAADKLLSLPIHQpHKIKQKPTTGLLAITLALHLCD 274
Cdd:cd23967  80 DLLWLQAVIKGKKPNgKGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNG-KQGKNVPTTGIIAIVMALHYCD 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 45430035 275 LVHIAGFGYPDAhQKKQSIHYYEYITLKSM-MWSGHNVSQEALAIKRM 321
Cdd:cd23967 159 EVDIAGFGYDPS-DPNAPLHYYDSLTMKAIkRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 116-321 6.65e-78

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 236.95  E-value: 6.65e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 116 KCRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMRLFYPESAHFNPKVEDnPDTLLVLVAFKAM 195
Cdd:cd23984   1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYD-PNTTVVLIPFKPH 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 196 DFHWIESILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFYMEIAADKLLSLPIHQP-HKIKQKPTTGLLAITLALHLCD 274
Cdd:cd23984  80 DLRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPkEKKPKHPTTGIIAITLALHICN 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 45430035 275 LVHIAGFGYpDAHQKKQSIHYYEYITLKSMMWSG-HNVSQEALAIKRM 321
Cdd:cd23984 160 EVHIAGFKY-DFSNLNSTLHYYGNETMSVMTKNEyHNISAEQKFLKDL 206
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 84-326 8.50e-66

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 207.85  E-value: 8.50e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035    84 YELPYgtKGSEDLLLRVLAITSysipesIQSLKCRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKT 163
Cdd:pfam00777  18 WWLPF--TVTEELLELLPKVSP------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035   164 TMRLFYPESA---HFNPKVEDN---PDTLLVLVAFKAMDFHWIESILSdKKRVRKGFWKQP---PLIWDVNPKQIRILNP 234
Cdd:pfam00777  90 TLRTMNPESAidsKYGNLGFSHprdPFVEFVLVPFKGRDLLWLPAFLT-KGNVSRSLRVLYtlkEVKIPVDPDKVLFLHP 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035   235 FYMEIAADKLLSLPIHQPHkikqKPTTGLLAITLALHLCDLVHIAGFGYPDaHQKKQSIHYYEYITLKSMMWSG-HNVSQ 313
Cdd:pfam00777 169 DFLRYVANFWLRSHGLKGR----RPSTGLLMLSLALHLCDEVSLYGFGPFL-DSRGNSHHYYDNVLMKKGGFYGvHDMPF 243

                         250
                  ....*....|...
gi 45430035   314 EALAIKRMLEIGA 326
Cdd:pfam00777 244 EFKLLQKLHKEGV 256
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 117-321 1.12e-64

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 203.43  E-value: 1.12e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 117 CRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMRLFYPESAhfnPKV--EDNPDTLLVLVAFKA 194
Cdd:cd23983   2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGA---PKSeqEYDPTSLFVAVLFKS 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 195 MDFHWIESILSDKKR---VRKGFWKQPPLIWDVNPKQIRILNPFYMEIAADKLLSLPihQPHKI-----KQKPTTGLLAI 266
Cdd:cd23983  79 VDFAWLKAMVKKEPLsfwSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYP--EPQSRlwgwdKNVPTLGVTAV 156

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 45430035 267 TLALHLCDLVHIAGFGYpDAHQKKQSIHYYEYITLKSMMWSG-HNVSQEALAIKRM 321
Cdd:cd23983 157 VLATHLCDEVSLAGFGY-DLSQPHAPLHYYDSVCMAAMNTQTmHNVTKETKFLKKL 211
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 117-321 2.33e-58

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 187.05  E-value: 2.33e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 117 CRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMRLFYPESAHFNPKVEDNpDTLLVLVAFKAMD 196
Cdd:cd23981   2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEK-DSLFVLAGFKWQD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 197 FHWIESIL-SDKKRVRKGFWKQPPLIWDVNPKQIRILNPFYMEIAADKLLSLPIHQPHKIKQK-PTTGLLAITLALHLCD 274
Cdd:cd23981  81 FKWLKYIVyKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNiPTLGSVAITMALHNCD 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 45430035 275 LVHIAGFGYpDAHQKKQSIHYYEYITLKSMM--WSgHNVSQEALAIKRM 321
Cdd:cd23981 161 EVAVAGFGY-DMNTPNAPLHYYETIKMSAIKesWT-HNIQREKEFLRKL 207
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 116-328 5.33e-49

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 165.15  E-value: 5.33e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 116 KCRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMRLFYPESAhfnpkVEDNPDTLLVLVAFKAM 195
Cdd:cd23966  76 RCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESA-----VDLDPGVHLVLVPFKVL 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 196 DFHWIESILSDKKRVRKgfWKQPPLIWDVNPKQIRILNPFYMEIAADKLLslpihqpHKIKQKPTTGLLAITLALHLCDL 275
Cdd:cd23966 151 DLQWLISALTTGEITRT--YTPVKRFIKADKDKVLVINPAFIKYVHDNWT-------EHHGRYPSTGFLALIFALHICDE 221

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 45430035 276 VHIAGFGypdAHQKKQSIHYYEYITLKSMMWSG--HNVSQEALAIKRMLEIGAVK 328
Cdd:cd23966 222 VSVFGFG---ADSKGNWHHYWEKNRSAGAFRKTgvHDADFESDIIKKLAKEGKIR 273
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 82-314 1.12e-41

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 146.63  E-value: 1.12e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035  82 SLYELPYGTKG-SEDLLLRVLAITSYSIPESI-----QSLKCRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGY 155
Cdd:cd23964  41 SHYKLPFGWGGlNREVVERLLRNLNLTSSRYMfvlrgGRPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGF 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 156 EQDVGSKTTMRLFYPESAHfNPKVEDNP---DTLLVLVAFKAMDFHWIESILSDKKRVR---KGFWKQPPLIWDVNPKQI 229
Cdd:cd23964 121 EKDVGTKTSFYTFFPESLH-NSLLKHVPqdkDTKYLFIPFKIRDYDYLDAVLSGKPVPDgcdKGKRPPPLFGPKLNATNV 199

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 230 RILNP-FYMEIAADKLLSLPIHqphkikqKPTTGLLAITLALHLCDLVHIAGFGYPDahqkKQSIHYYEYiTLKSMMWSG 308
Cdd:cd23964 200 RLLHPdFIRYLFNRWLNSSTSY-------RPTTGALMLLTALHTCDQVSVYGFGYDP----RFSLHYYDK-TFVKFTVFY 267


                ....*...
gi 45430035 309 --HNVSQE 314
Cdd:cd23964 268 anHDFTNE 275
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 120-321 1.09e-40

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 140.96  E-value: 1.09e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 120 CVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMRLFYPESAHF---NPKVEDNPDTLLVLVAFKAMD 196
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFylrGPRCGCHPLPLEEEVVLILSR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 197 FHWIESILSDKKRVRKgfwKQPPLIwdVNPKQIRILNpfymeiAADKLLSLPIHQPHKIKQKPTTGLLAITLALHLCDLV 276
Cdd:cd19952  81 AAAADFKRLKRRKKRH---DNAVLL--LTDPAPDLLS------YVRKRLEKLGLKSFFGGNAPSSGLLAVLLALQLCDSV 149

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 45430035 277 HIAGFGYPDAHQKKQSIHYYEYITLKSMMWSgHNVSQEALAIKRM 321
Cdd:cd19952 150 DLYGFGVDSGHAPKVPYHYYDLVEAEEGTAV-HSFDLEAELLRAL 193
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 114-297 1.45e-32

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 122.30  E-value: 1.45e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 114 SLKCRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMRLFYPESAHfnpkvEDNPDTLLVLVAFK 193
Cdd:cd23980  78 LVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFR-----ELAQNVSMILVPFK 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 194 AMDFHWIESILSdKKRVRKGFWKQPPLIwDVNPKQIRILNPFYMEIAADKLLslpihQPHkiKQKPTTGLLAITLALHLC 273
Cdd:cd23980 153 TLDLEWVISATT-TGTISHTYVPVPRKI-KVKKEKILIYHPAFIKYVFDRWL-----QGH--GRYPSTGILSVIFSLHVC 223

                       170       180
                ....*....|....*....|....
gi 45430035 274 DLVHIAGFGypdAHQKKQSIHYYE 297
Cdd:cd23980 224 DEVDLYGFG---ADSKGNWHHYWE 244
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 115-297 5.61e-31

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 118.05  E-value: 5.61e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 115 LKCRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMRLFYPESAHFNPkvednPDTLLVLVAFKA 194
Cdd:cd23979  78 SRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLP-----ANVSFVLVPFKT 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 195 MDFHWIESILSdKKRVRKGFWKQPPLIwDVNPKQIRILNPFYMEIAADKLLSlpiHQphkiKQKPTTGLLAITLALHLCD 274
Cdd:cd23979 153 LDLLWITSALS-TGQIRFTYAPVKQFL-RVDKDKVQIYNPAFFKYIHDRWTE---HH----GRYPSTGMLVLFFALHVCD 223

                       170       180
                ....*....|....*....|...
gi 45430035 275 LVHIAGFGypdAHQKKQSIHYYE 297
Cdd:cd23979 224 EVNVYGFG---ADSRGNWHHYWE 243
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 118-328 1.04e-26

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 106.19  E-value: 1.04e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 118 RRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTM---------RLFYPESAHFNPKV-----EDNP 183
Cdd:cd23963  64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLttlnpsilkRRYNSLKKNRDRDKflnrlKEYN 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 184 DTLLVLVAFkamdfhwiesilSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFYMEIAADKLlslpihQPHKIKQKPTTGL 263
Cdd:cd23963 144 GSILWYPKF------------SFKSSTNLLLKAARALKKNGLNLTVVYSNPEHFLAVQKFW------KRRGLEKRPSTGL 205

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45430035 264 LAITLALHLCDLVHIAGFgYP---DAHQKKQSIHYYEYITLKSMMWSgHNVSQEALAIKRMLEIGAVK 328
Cdd:cd23963 206 YLVSLALTFCDEIHLYGF-WPfptDPNGRPVPYHYYDDLSPSTKNKV-HNMPEEFKLLRELHKKGVLK 271
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 114-297 1.92e-24

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 100.98  E-value: 1.92e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 114 SLKCRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTmrlFYPESAH-------------FNpKVE 180
Cdd:cd23973  80 GDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTS---FYVHTAHsitsslmilqkrgFK-NIP 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 181 DNPDTLLVLVAFKAMDFHWIESILSDKKRVRKGFWKQPPLIW---DVNPKQIRILNPFYMEIAADKLL-SLPIHQPHKIK 256
Cdd:cd23973 156 QDKDIKYILFPEGPRDYQWLEALLKNKTIPSGAYYGRRPRSYfsgDFTEDKYLVLHPDFLRYVKNRFLrSKTLKGKYWAI 235

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 45430035 257 QKPTTGLLAITLALHLCDLVhiAGFGYPDAHQKKQSIHYYE 297
Cdd:cd23973 236 YRPTTGAFLLLTALHLCDTV--SAYGFITEDYRKYPDHYYD 274
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 118-321 2.59e-23

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 96.96  E-value: 2.59e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 118 RRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMRL-----FYPESAHFNPKVEDNPDTLLVlvaF 192
Cdd:cd23968  46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLinsqiLSKPEFNFLTDPLYRNVTLLV---W 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 193 KAMDFHwiesilsdkkRVRKGFWKQPPliWDVNPKQIR-----------ILNPFYMEIAADKLLSlpiHQPHKIKQK-PT 260
Cdd:cd23968 123 DPSSYN----------VNLEKWYKKPD--FDFFPNYIKyrrrhpeepfyLIDPRFLWRLWDILQE---YTPEKIKPNpPS 187

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45430035 261 TGLLAITLALHLCDLVHIagFGYPDAHQKKQSIHYYE-YITLKSMMWSGHNVSQEALAIKRM 321
Cdd:cd23968 188 SGFIGIVLMLHLCDWVDV--YEYVPSVRQTDRCHYYDvEKDLACTLGAWHPLAAEKLLVRHL 247
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 117-297 2.97e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 90.38  E-value: 2.97e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 117 CRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMRLFypesAHFN-PKVEDNPDTLLVLVAFKAM 195
Cdd:cd23965   1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVV----SHSSlPRLLRNAILLLAGTRAPTV 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 196 DFHWiesiLSDKKRVRKGFwKQPPLIW---DVNPK-QIRILNPfYMEIAADKLLSLPIHQP-HKIKQKPTTGLLAITLAL 270
Cdd:cd23965  77 VVFW----GPETKMNKDGA-GKYNLLRslsKKYPDvEFYSLTP-EKMDYADELFEKETGKSrIKSGTWLSTGWFTMLLAL 150

                       170       180       190
                ....*....|....*....|....*....|.
gi 45430035 271 HLCDLVHIAGFGYPD---AHQKKQS-IHYYE 297
Cdd:cd23965 151 DVCDEIKVYGMVPENycrEHPNSKVpYHYYE 181
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 118-331 3.54e-21

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 91.32  E-value: 3.54e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 118 RRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSK---TTMrlfypesahfNPKVednpdtllVLVAFKA 194
Cdd:cd23969  65 RTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKsnlTTM----------NPSV--------IPHAYGD 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 195 MDF-HWIESILSDKKRVRKGFWKQPPLIWDVNPKQIRILNpfymEIAADKLLSL-----PIHQPHKIK----------QK 258
Cdd:cd23969 127 LVNaTDKEKFVERLRQLGDSILWIPAFVSKGGEEHVQWTN----EIILKHKLNVktaypPLRLNHAIRgywlttkfriKR 202

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45430035 259 PTTGLLAITLALHLCDLVHIAGFgYP---DAHQKKQSIHYY---EYITLKsmmwSGHNVSQEALAIKRMLEIGAVKNLT 331
Cdd:cd23969 203 PSTGLLMYTLATRFCDEIHLYGF-YPfseDGNGRAVKYHYYdnrKYLTTA----RPHKMPEEFRALRSLHQRGALRLHT 276
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 71-297 9.08e-21

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 90.15  E-value: 9.08e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035  71 QLKDYFWVKTPSLYELPYGTKGSEDLLlrvlaiTSYSIPESIQSLKcrRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSA 150
Cdd:cd23985   7 ELKDKVNVSMLEGTDFPFNTSEWEGYL------PKKSLREEVGPLG--RCAVVSSAGSLKSSGLGREIDSHDAVLRFNGA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 151 PVAGYEQDVGSKTTMRLFYP-----ESAHFnpkVEDNPDTLLVLVAFKAMDFH-----WIES----ILSDKKRVRKGFWK 216
Cdd:cd23985  79 PTAGFQQDVGTKTTIRLINSqlvttEKHKF---LKDSLYNEGILIVWDPAPYHsdipeWYKNpdynFFENYKTYRRLNPN 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 217 QPPLIwdVNPKQIRILNPFYMEIAADKLlslpihQPHkikqKPTTGLLAITLALHLCDLVHIAGFgYPdAHQKKQSIHYY 296
Cdd:cd23985 156 QPFYI--LHPQMQWELWDIIQENSPEEI------QPN----PPSSGMLGIILMMTLCDQVDVYEF-LP-SKRKTDVCHYY 221


                .
gi 45430035 297 E 297
Cdd:cd23985 222 Q 222
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 117-328 2.93e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 86.73  E-value: 2.93e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 117 CRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTmrlFYPESAH--FN-------------PKVED 181
Cdd:cd23974  84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTS---FYTFSTNtlMNslrayagvgfngpPQSKE 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 182 ---------NPDTLLVLVAfkamdfhwIESILSDKKRVRKgfwKQPPLIW--DVNPKQIRILNPFYMEIAADKLLSLPI- 249
Cdd:cd23974 161 tryiflpdhDRDYLLVKAA--------LTHTPIDRGRDKS---KRPSKYFgkDVTAEKFKIYHPDFIRYLRNRFLWSPIl 229

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45430035 250 HQPHKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDahQKKQSIHYYEYITLKSMMWSGHNVSQEALAIKRMLEIGAVK 328
Cdd:cd23974 230 NTKQRDIYRPSTGAVMLLAALHTCDQVSAYGFMTPD--YGKYSDHYYDKTYHKVVFYANHDLRLEMQLWQKLHKAGLIK 306
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 82-328 9.67e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 85.26  E-value: 9.67e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035  82 SLYELPYGTKG--SEDL--LLRVLAITSYS--IPESIQSLKCRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGY 155
Cdd:cd23972  41 SQRKVPYGWKGlsHQVVasTLSLLNDSANAklFFPRDTPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGF 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 156 EQDVGSKTTmrlFYpesaHFNPKVEDNPdtllvLVAFKAMDFH-----------WIESILSDKKRVRKGFWKQP-PLIWD 223
Cdd:cd23972 121 EEDVGTKTS---FY----GFTVNTMKNS-----LISYWNLGFTrtpqgqdlqyiFIPSDIRDYVMLRSAILGVPvPEGLD 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 224 ------------VNPKQIRILNPFYMEIAADKLLS---LPIHQPHKIkqKPTTGLLAITLALHLCDLVHIAGFGYPDahQ 288
Cdd:cd23972 189 kgdrphkyfgpeASAKKFKLLHPDFISYLTDRFLKsklLNTHYGHLY--MPSTGALMLLTALHTCDQVSAYGFITSN--Y 264

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 45430035 289 KKQSIHYYEYITLKSMMWSGHNVSQEALAIKRMLEIGAVK 328
Cdd:cd23972 265 WKFSDHYYERKKKPLVFYANHDMLLEAALWRRLHKAGILQ 304
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 63-321 2.29e-18

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 83.35  E-value: 2.29e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035  63 SREQpFFLQLKDYFWVKTPSLYELPYGTKGSEDLLLRvlaitsysIPES-IQSLKCRRCVVVGNGHRLRNSSLGEAINKY 141
Cdd:cd23986   3 SRQE-LLCELKKRVQVRTLDGKEAPFSALGWEKYVPK--------IPLSkLHLRGFRSCAVVTSAGAILNSSLGKEIDSH 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 142 DVVIRLNSAPVAGYEQDVGSKTTMRLFYPE-----SAHFNpkveDNP---DTLLVL---VAFKAMDFHWIE----SILSD 206
Cdd:cd23986  74 DAVLRFNSAPTRGYEKDVGNKTTIRIINSQiltnpNHHFI----DSSlykDVILVAwdpAPYSANLHKWYKkpdyNLFTP 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 207 KKRVRKGFWKQPPLIwdVNPKQIRILNPFYMEIAADKLlslpihQPHkikqKPTTGLLAITLALHLCDLVHIagFGYPDA 286
Cdd:cd23986 150 YVQYRKRNPNQPFYI--LHPKFIWQLWDIIQENTQEKI------QPN----PPSSGFIGILIMMSMCREVHV--YEYIPS 215

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 45430035 287 HQKKQSIHYYE-YITLKSMMWSGHNVSQEALAIKRM 321
Cdd:cd23986 216 VRQTDLCHYHErYYDAACTLGAYHPLLYEKLLIQRM 251
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 108-328 3.17e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 83.21  E-value: 3.17e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 108 IPES--IQSLKCRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMrlfypesAHFNPKVEDNPDT 185
Cdd:cd23970  57 LPEVspFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNL-------TTFNPSILEKYYN 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 186 LLVLVAFKAmdfhwieSILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFYMEIAADKLLSLPIhqPHKI---------- 255
Cdd:cd23970 130 NLLTIQDRN-------NFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAW--PGNImqhvnrywkt 200

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 256 -KQKP---TTGLLAITLALHLCDLVHIAGF-GYPDAHQKKQ-SIHYYEYITLK-SMMWS-GHNVSQEALAIKRMLEIGAV 327
Cdd:cd23970 201 kHLSPkrlSTGILMYTLASAICEEIHLYGFwPFGFDPTGTPlPYHYYDKKGTKfTTKWQeSHQLPAEFVLLYKMHGAGVL 280


                .
gi 45430035 328 K 328
Cdd:cd23970 281 K 281
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 99-331 2.19e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 78.07  E-value: 2.19e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035  99 RVLAITS--YSIPESIQSLKCRR---CVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSK---TTM----- 165
Cdd:cd23988  41 RTLNISQnlHSLLPEVSPMKNRRfktCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKsdfITMnpsvv 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 166 -RLF-----YPESAHFNPKVEDNPDTLLVLVAF--KAMDFH--WI-ESILSDKKRVRKGFwkqPPLiwdvnpKQIRILNP 234
Cdd:cd23988 121 qRAFggfrnESDREKFVHRLSMLNDSVLWIPAFmvKGGEKHveWVnALILKNKLKVRTAY---PSL------RLIHAVRG 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 235 FYMEiaadkllslpihqpHKIK-QKPTTGLLAITLALHLCDLVHIAGF-GYP-DAHQKKQSIHYYEYITLKSMMWSG-HN 310
Cdd:cd23988 192 YWLT--------------NKVNiKRPSTGLLMYTLATRFCDEIHLYGFwPFPkDANGNPVKYHYYDDLKYRYFSNAGpHR 257

                       250       260
                ....*....|....*....|.
gi 45430035 311 VSQEALAIKRMLEIGAVKNLT 331
Cdd:cd23988 258 MPLEFKTLNVLHNRGALKLTT 278
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 106-328 7.81e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 76.52  E-value: 7.81e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 106 YSIPESIQSLKCRR---CVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMrlfypesAHFNPKVedn 182
Cdd:cd23987  50 YELLPRTSPLKNKHfktCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDL-------VTMNPSV--- 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 183 pdtllVLVAFK-AMDFHWIESILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFYMEIAADKLLSLP-IHQPHKIK---- 256
Cdd:cd23987 120 -----VQRAFEdLVNETWKEKFLQRLQSLNGSILWIPAFMAKGGEERVEWVNDLILKHHINVRTAYPsLRLLHAVRgywl 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 257 ------QKPTTGLLAITLALHLCDLVHIAGFgYP---DAHQKKQSIHYYEYITLK-SMMWSGHNVSQEALAIKRMLEIGA 326
Cdd:cd23987 195 tnkvhiKRPTTGLLMYTLATRFCNRIHLYGF-WPfprDQNQNPVKYHYYDSLKYGyTSQASPHTMPLEFKALKNLHQQGA 273


                ..
gi 45430035 327 VK 328
Cdd:cd23987 274 LK 275
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 119-328 1.70e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 72.29  E-value: 1.70e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 119 RCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAgYEQDVGSKTTM--------RLFYPE----SAHFNPKVEDNPDTL 186
Cdd:cd23971  66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNLvtanpsilREKFHNlkkrRRPFVERMKVYGNAL 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 187 LVLVAFkAMDFHWIESI-----LSDKKrvrkgfwkqppliwdvNPKQIRILNPFYMEIAADKLLSLPIHQphkikQKPTT 261
Cdd:cd23971 145 LLLPAF-SYTSNTEPSLralytLEDFG----------------SPQKVLFFNPEYLRNLSRYWKSKGLKA-----RRLST 202

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 262 GLLAITLALHLCDLVHIAGFgYP---DAHQKKQSIHYYEYITLKSMMwsgHNVSQEALAIKRMLEIGAVK 328
Cdd:cd23971 203 GLMLVSAALELCENVHLYGF-WPfstDLDGNPISHHYYDNVLPKKGV---HAMPEEFLRYLKLHSQGVLR 268
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 117-297 1.69e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 68.73  E-value: 1.69e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 117 CRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMRLFYPESAHfnpKVEDNPDTLLVLVAFKAMD 196
Cdd:cd23978   1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVY---RVLRRPQEFLNRTPETTLI 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 197 FhW--IESILSDKKRVRKGFWKQPPLI------WDVNPKQIRIL-NPFYMEIAADKllslpihqpHKIKQKPTTGLLAIT 267
Cdd:cd23978  78 F-WgpPNKMQKDGKSNLFRIIQRASMTfpnmsaFVVSPRRMRQFdDLFRGETGRDR---------KKSHSWLSTGWFTMV 147

                       170       180       190
                ....*....|....*....|....*....|....*
gi 45430035 268 LALHLCDLVHIAGFGYPD-----AHQKKQSIHYYE 297
Cdd:cd23978 148 IAVELCDNVHVYGMVPPNycskrPTPKKMPYHYYE 182
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 118-328 1.23e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 67.09  E-value: 1.23e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 118 RRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAG-YEQDVGSKTTM-------------------RLFYPESAHFNp 177
Cdd:cd23991  65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNLvtanpsiisikyaklnerrKPFLETVSVYG- 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 178 kvednpDTLLVLVAFK-----AMDFHwIESILSDKKRvrkgfwKQPPLiwdvnpkqirILNPFYMEIAADKLLSLPIHQp 252
Cdd:cd23991 144 ------DAFLLLPAFSyrsntALSFK-VYYTLEDFKA------KQKVI----------FFHPIYLKHLAQFWRSKGVQV- 199

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45430035 253 hkikQKPTTGLLAITLALHLCDLVHIAGFgYP---DAHQKKQSIHYYEYITLKSmmwSGHNVSQEALAIKRMLEIGAVK 328
Cdd:cd23991 200 ----YRLSTGLMITSAALELCEEVKLYGF-WPfskNTEGKPISHHYYDNQLPKP---GFHSMPKEFYQLLQLHSKGILK 270
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 115-328 6.69e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 64.85  E-value: 6.69e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 115 LKCRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVA-GYEQDVGSKTTMrlfypesAHFNPKVEDN--PDTLLVLVA 191
Cdd:cd23989  61 LPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLSrEYTDDVGTKTQL-------VTANPSIIDKrfQNLLWSRKS 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 192 F----KAMDFHWIE-SILSDKKRVRKGFWKQPPLIwDVNPKQIRIL-NPFYMEIAADKLLSLPIHqphkiKQKPTTGLLA 265
Cdd:cd23989 134 FvesmKVYGRSYIYmPAFSMKTGTDPSLRVYYTLA-DVGANQTVLFaNPNFLRNVGKFWKSKGVH-----AKRLSTGLFL 207

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45430035 266 ITLALHLCDLVHIAGFgYP---DAHQKKQSIHYYEYITLKSmmwSGHNVSQEALAIKRMLEIGAVK 328
Cdd:cd23989 208 VSAALGLCEEVTIYGF-WPfsvDLDERTISHHYYDNVLPDS---GFHAMPEEFLQLWHLHKSGVLR 269
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 117-167 3.34e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 62.19  E-value: 3.34e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 45430035 117 CRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMRL 167
Cdd:cd23977   1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRV 51
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 115-297 1.34e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 60.65  E-value: 1.34e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 115 LKCRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMRLFYPESAHfnpKVEDNPDTLLVlVAFKA 194
Cdd:cd23976  13 MHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQ---RILRNRNELLN-VSQGT 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 195 MDFHWIESilSDKKRVRKGF-WKQPPLIWDVNPK-QIRILNPFYMeIAADKLLSLPIHQPHKIKQK-PTTGLLAITLALH 271
Cdd:cd23976  89 VFIFWGPS--NYMRRDGKGLvYNNLQLMNQILPKlKVYTITRHKM-LQFDELFKRETGKDRKISNTwLSTGWFTMIIALE 165

                       170       180       190
                ....*....|....*....|....*....|
gi 45430035 272 LCDLVHIAGFGYP----DAHQKKQSIHYYE 297
Cdd:cd23976 166 LCDRINVYGMVPPdfcrDPNHPSVPYHYYE 195
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 118-297 1.49e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 54.84  E-value: 1.49e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 118 RRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAG-YEQDVGSKTTMRLFYP----ESAH--------FNPKVEDNPD 184
Cdd:cd23990  65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEkYVRDVGVKTDVVTINPsiitERFHklekwrrpFYEVLQVYEN 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45430035 185 TLLVLVAF---KAMDFHW-IESILSDKKrvrkgfwkqppliwdvNPKQIRILNPFYMEIAADKLLSLPIHqphkiKQKPT 260
Cdd:cd23990 145 ASVVLPAFyntRNTDVSIrVKYVLDDFE----------------SQQAVYYFHPQYLLNVSRFWLRQGVR-----AKRIS 203

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 45430035 261 TGLLAITLALHLCDLVHIAGF-GYP-DAHQKKQSIHYYE 297
Cdd:cd23990 204 SGLMLVTAALELCEEVHLYGFwAFPmNPSGIFITHHYYD 242
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 117-184 5.58e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 49.93  E-value: 5.58e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45430035 117 CRRCVVVGNGHRLRNSSLGEAINKYDVVIRLNSAPVAGYEQDVGSKTTMRLFYPESAhfnPKVEDNPD 184
Cdd:cd23975   1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSV---PLLLKNPD 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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