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Conserved domains on  [gi|134053883|ref|NP_997303|]
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solute carrier family 2, facilitated glucose transporter member 7 [Homo sapiens]

Protein Classification

SLC2A family MFS transporter( domain architecture ID 13024547)

SLC2A (solute carrier family 2, facilitated glucose transporter) family major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of hexoses such as glucose and fructose

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26098515|26758938
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
26-477 0e+00

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 693.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  26 ATLSAAFGSAFQYGYNLSVVNTPHKVFKSFYNETYFERHATFMDGKLMLLLWSCTVSMFPLGGLLGSLLVGLLVDSCGRK 105
Cdd:cd17432    1 ATLAAAFGSSFQYGYNLSVVNSPTPYIQNFYNETWTERYGTPLEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIRLGRK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 106 GTLLINNIFAIIPAILMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFLAQI 185
Cdd:cd17432   81 GTLLLNNIFAIVAAILMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 186 FSLQAILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYSLIQKGDEATARQALRRLRGHTDMEAELEDMRAEARAERA 265
Cdd:cd17432  161 LGLRELLGNEEGWPLLLALTGVPALLQLLTLPFFPESPRYLLIEKGDEEAARKALQRLRGKEDVDDEMEEMLEEQRAEKG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 266 EGHLSVLHLCALRSLRWQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITSAVLVERL 345
Cdd:cd17432  241 VGTVSVLELFRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEDKIQYVTVGTGACEVLATITCVLVIERL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 346 GRRHLLLAGYGICGSACLVLTVVLLFQNRVPELSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFMVDGAVH 425
Cdd:cd17432  321 GRRPLLIGGFGLMAVWCAVLTVALSLQNTVSWMPYLSIVCIFAYIASFGIGPAGVPFILTTEIFDQSSRPAAFMVAGSLN 400
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 134053883 426 WLTNFIIGFLFPSIQEAIGAYSFIIFAGICLLTAIYIYVVIPETKGKTFVEI 477
Cdd:cd17432  401 WLSNFLVGLLFPFIQEGLGAYCFLVFAVICLLTAIYIFFVLPETKGKTFLEI 452
 
Name Accession Description Interval E-value
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
26-477 0e+00

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 693.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  26 ATLSAAFGSAFQYGYNLSVVNTPHKVFKSFYNETYFERHATFMDGKLMLLLWSCTVSMFPLGGLLGSLLVGLLVDSCGRK 105
Cdd:cd17432    1 ATLAAAFGSSFQYGYNLSVVNSPTPYIQNFYNETWTERYGTPLEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIRLGRK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 106 GTLLINNIFAIIPAILMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFLAQI 185
Cdd:cd17432   81 GTLLLNNIFAIVAAILMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 186 FSLQAILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYSLIQKGDEATARQALRRLRGHTDMEAELEDMRAEARAERA 265
Cdd:cd17432  161 LGLRELLGNEEGWPLLLALTGVPALLQLLTLPFFPESPRYLLIEKGDEEAARKALQRLRGKEDVDDEMEEMLEEQRAEKG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 266 EGHLSVLHLCALRSLRWQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITSAVLVERL 345
Cdd:cd17432  241 VGTVSVLELFRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEDKIQYVTVGTGACEVLATITCVLVIERL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 346 GRRHLLLAGYGICGSACLVLTVVLLFQNRVPELSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFMVDGAVH 425
Cdd:cd17432  321 GRRPLLIGGFGLMAVWCAVLTVALSLQNTVSWMPYLSIVCIFAYIASFGIGPAGVPFILTTEIFDQSSRPAAFMVAGSLN 400
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 134053883 426 WLTNFIIGFLFPSIQEAIGAYSFIIFAGICLLTAIYIYVVIPETKGKTFVEI 477
Cdd:cd17432  401 WLSNFLVGLLFPFIQEGLGAYCFLVFAVICLLTAIYIFFVLPETKGKTFLEI 452
Sugar_tr pfam00083
Sugar (and other) transporter;
26-481 4.83e-112

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 339.63  E-value: 4.83e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883   26 ATLSAAFGSaFQYGYNLSVVNTPHKVFKSFYNETYFERHATFMDGKLmllLWSCTVSMFPLGGLLGSLLVGLLVDSCGRK 105
Cdd:pfam00083   1 VALVAALGG-FLFGYDTGVIGAFLTLIDFFKNFGLSKSVSSLAALSV---LSGLIVSIFSVGCFIGSLFAGKLGDRFGRK 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  106 GTLLINNIFAIIPAILMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFLAQI 185
Cdd:pfam00083  77 KSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYI 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  186 FSLQ-AILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYsLIQKGDEATARQALRRLRGHTDMEAELEDMRAEARAER 264
Cdd:pfam00083 157 FGLGlNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRW-LVEKGRLEEAREVLAKLRGVPDVDRELDEIKDSLEAGQ 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  265 AEGHLSVLHLCALRSLRWQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAahSQYVTVGSGVVNIVMTITSAVLVER 344
Cdd:pfam00083 236 EAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSD--SFLVTIIVGVVNFVFTFIAIFLVDR 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  345 LGRRHLLLAGYGICGSACLVLT-VVLLFQNRVPELSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFMVDGA 423
Cdd:pfam00083 314 FGRRPLLLLGAAGMAICFVILGiVALLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATA 393
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 134053883  424 VHWLTNFIIGFLFPSIQEAIG-AYSFIIFAGICLLTAIYIYVVIPETKGKTFVEINRIF 481
Cdd:pfam00083 394 ANWLANFLIGFLFPIITDAIGlGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDELF 452
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
17-477 3.42e-101

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 312.74  E-value: 3.42e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883   17 GRLQPTLLLATLSAAFGSaFQYGYNLSVVNtphkvfkSFYNETYFERHATFMDGKLML-LLWSCTVSMFPLGGLLGSLLV 95
Cdd:TIGR00879  20 GSTYWKVALLSLIAAIGG-LMFGYDTGVIG-------GALALPAFEFKFTSANSDSYSsSLWGLVVSIFLVGGFIGALFA 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883   96 GLLVDSCGRKGTLLINNIFAIIPAILMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVF 175
Cdd:TIGR00879  92 GWLSDRFGRKKSLLIIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLA 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  176 VIVGVFLAQIFSLQA-ILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYsLIQKGDEATARQALRRLRGHTDMEAELE 254
Cdd:TIGR00879 172 ITFGILVAYGFGSGKvSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRW-LVGKGRVEEARKSLARLRGTSGEDKELL 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  255 DMRAEARAERAEGHLSVLHLCA-----LRSLRWQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGV 329
Cdd:TIGR00879 251 DELELIDIKRSIEKRSVQPSWGslfssTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGA 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  330 VNIVMTITSAVLVERLGRRHLLLAGYGICGSACLVLTVVLLFQ--NRVPELSYLGIICVFAYIAGHSIGPSPVPSVVRTE 407
Cdd:TIGR00879 331 VNFAFTFVAIFLVDRFGRRPLLLIGAAGMAICLFVLGILGASFvtGSSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSE 410
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 134053883  408 IFLQSSRRAAFMVDGAVHWLTNFIIGFLFPSIQEAIG-AYSFIIFAGICLLTAIYIYVVIPETKGKTFVEI 477
Cdd:TIGR00879 411 IFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGvGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
xylE PRK10077
D-xylose transporter XylE; Provisional
135-486 1.52e-38

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 146.76  E-value: 1.52e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 135 VFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFLAQIFSLQAILGNPA------GWPVLLALTGVP 208
Cdd:PRK10077 124 VIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYFVNYFIARSGDAswlntdGWRYMFASEAIP 203
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 209 ALLQLLTLPFFPESPRYsLIQKGDEATARQALRRLRGHTDMEAELEDMRAEARAERAEGHlsvlhlcalRSLRWQLLSII 288
Cdd:PRK10077 204 ALLFLMLLYFVPETPRY-LMSRGKQEQAEGILRKIMGNTLATQALQEIKHSLDHGRKTGG---------KLLMFGVGVIV 273
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 289 V---LMAGQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITSAVLVERLGRRHLLLAGYgiCGSACLVL 365
Cdd:PRK10077 274 IgvmLSVFQQFVGINVVLYYAPEIFKTLGASTDIALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQIIGA--LGMAIGMF 351
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 366 TVVLLFQNRVPELsyLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFMVDGAVHWLTNFIIGFLFPSIQEAI-- 443
Cdd:PRK10077 352 SLGTAFYTQAPGI--VALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAIRGKALAIAVAAQWIANYFVSWTFPMMDKNSwl 429
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 134053883 444 -----GAYSFIIFAGICLLTAIYIYVVIPETKGKTFVEINRIFAKRNR 486
Cdd:PRK10077 430 vahfhNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEEMEALWEPETK 477
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
103-472 3.29e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 71.07  E-value: 3.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 103 GRKGTLLINNIFAIIPAILMGVskvAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFL 182
Cdd:COG2223   68 GPRRVLLIGLLLLGIGLLLLAL---AVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAV 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 183 AQIFSlqAILGNPAGWPVLLALTGVPALL-QLLTLPFFPESPrysliqKGDEATARQALRRLRGhtdmeaeledmraear 261
Cdd:COG2223  145 AAFLA--PLLIAAFGWRNAFLILGILLLVvAVLAWLFLRDPP------AGAAAAAKASLRDQLE---------------- 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 262 aeraeghlsvlhlcALRSLRWQLLSIIVLMAGqqlSGINAINYYADTIYTSA-GVEAAHSQYVTVGSGVVNIVMTITSAV 340
Cdd:COG2223  201 --------------ALRDPRFWLLSLLYFGTF---GSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGW 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 341 LVERLGRRHLLLAGYGICGSACLVLtvvLLFQNRVPelsyLGIICVFAYIAGHSIGPSPVPSVVRtEIFLQSSRRAAFMV 420
Cdd:COG2223  264 LSDRIGGRRVLLIVFALMALGLLLL---ALALGSLW----LFLVLFLLLGLALGGGNGAVFALVP-DIFPTKNAGAVYGL 335
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 134053883 421 DGAVHWLTNFIIGFLFPSIQEAIGAYS--FIIFAGICLLTAIYIYVVIPETKGK 472
Cdd:COG2223  336 VGAAGGLGGFLGPLLFGALLDATGSYTaaFLVFAVLALVALVLTLLLYRRPRRA 389
 
Name Accession Description Interval E-value
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
26-477 0e+00

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 693.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  26 ATLSAAFGSAFQYGYNLSVVNTPHKVFKSFYNETYFERHATFMDGKLMLLLWSCTVSMFPLGGLLGSLLVGLLVDSCGRK 105
Cdd:cd17432    1 ATLAAAFGSSFQYGYNLSVVNSPTPYIQNFYNETWTERYGTPLEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIRLGRK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 106 GTLLINNIFAIIPAILMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFLAQI 185
Cdd:cd17432   81 GTLLLNNIFAIVAAILMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 186 FSLQAILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYSLIQKGDEATARQALRRLRGHTDMEAELEDMRAEARAERA 265
Cdd:cd17432  161 LGLRELLGNEEGWPLLLALTGVPALLQLLTLPFFPESPRYLLIEKGDEEAARKALQRLRGKEDVDDEMEEMLEEQRAEKG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 266 EGHLSVLHLCALRSLRWQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITSAVLVERL 345
Cdd:cd17432  241 VGTVSVLELFRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEDKIQYVTVGTGACEVLATITCVLVIERL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 346 GRRHLLLAGYGICGSACLVLTVVLLFQNRVPELSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFMVDGAVH 425
Cdd:cd17432  321 GRRPLLIGGFGLMAVWCAVLTVALSLQNTVSWMPYLSIVCIFAYIASFGIGPAGVPFILTTEIFDQSSRPAAFMVAGSLN 400
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 134053883 426 WLTNFIIGFLFPSIQEAIGAYSFIIFAGICLLTAIYIYVVIPETKGKTFVEI 477
Cdd:cd17432  401 WLSNFLVGLLFPFIQEGLGAYCFLVFAVICLLTAIYIFFVLPETKGKTFLEI 452
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
27-472 1.17e-146

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 427.83  E-value: 1.17e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  27 TLSAAFGSAFQYGYNLSVVNTPHKVFKSFYNETYFERHATFMDGKLMLLLWSCTVSMFPLGGLLGSLLVGLLVDSCGRKG 106
Cdd:cd17357    1 AVIVAFGGSFQFGYNIGVVNAPQEVFKEFINDTLVDRYGLNLSDSELDLLWSLIVSIFFIGGAIGSFISAFLANRFGRKN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 107 TLLINNIFAIIPAILMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFLAQIF 186
Cdd:cd17357   81 GLLISNALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 187 SLQAILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYSLIQKGDEATARQALRRLRGHTDMEA-ELEDMRAEARAERA 265
Cdd:cd17357  161 GLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISKGDEEEAEKSLKFLRGIEDDVDqELEEIKKESEQMGD 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 266 EGHLSVLHLCALRSLRWQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITSAVLVERL 345
Cdd:cd17357  241 QKQVSLMQLLRDPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKV 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 346 GRRHLLLAGYGICGSACLVLTVVLLFQNRVPELSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFMVDGAVH 425
Cdd:cd17357  321 GRRPLLLISLSVCAVALLLMSVFLFLSEQNSWMSYGCIVAIFLFIFFFAIGLGPIPWFIGAELFPQAPRSAAQSLGSSVN 400
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 134053883 426 WLTNFIIGFLFPSIQEAIGAYSFIIFAGICLLTAIYIYVVIPETKGK 472
Cdd:cd17357  401 WTSNFIVGMAFPPLQSIGGGFVFIIFAIPCALFLLYLYRYLPETKGR 447
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
25-472 5.51e-140

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 410.96  E-value: 5.51e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  25 LATLSAAFGSaFQYGYNLSVVNTPHKVFKSFYNETYFERHATFMDGKLMLLLWSCTVSMFPLGGLLGSLLVGLLVDSCGR 104
Cdd:cd17431    1 FAVFVAVLGS-LQFGYNTGVINAPQKVIEEFYNKTLGDRYGEPISPETLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGR 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 105 KGTLLINNIFAIIPAILMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFLAQ 184
Cdd:cd17431   80 RNSMLYNNLLAFAGAALMGLSKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 185 IFSLQAILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYSLIQKGDEATARQALRRLRGHTDMEAELEDMRAEARAER 264
Cdd:cd17431  160 IFGLEFILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLLINRNEEEEAKSVLKKLRGTTDVSEDIQEMKEESRQMM 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 265 AEGHLSVLHLCALRSLRWQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAAhsQYVTVGSGVVNIVMTITSAVLVER 344
Cdd:cd17431  240 REKKVTILELFRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQQP--VYATIGAGVVNTIFTVVSLFLVER 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 345 LGRRHLLLAGY-GICGSACLvLTVVLLFQNRVPELSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFMVDGA 423
Cdd:cd17431  318 AGRRTLHLIGLgGMAICAIL-MTIALLLLEGYPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGF 396
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 134053883 424 VHWLTNFIIGFLFPSIQEAIGAYSFIIFAGICLLTAIYIYVVIPETKGK 472
Cdd:cd17431  397 SNWTSNFIVGMCFQYIANLCGPYVFIIFTVFLLTFFIFTYFKVPETKGK 445
Sugar_tr pfam00083
Sugar (and other) transporter;
26-481 4.83e-112

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 339.63  E-value: 4.83e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883   26 ATLSAAFGSaFQYGYNLSVVNTPHKVFKSFYNETYFERHATFMDGKLmllLWSCTVSMFPLGGLLGSLLVGLLVDSCGRK 105
Cdd:pfam00083   1 VALVAALGG-FLFGYDTGVIGAFLTLIDFFKNFGLSKSVSSLAALSV---LSGLIVSIFSVGCFIGSLFAGKLGDRFGRK 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  106 GTLLINNIFAIIPAILMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFLAQI 185
Cdd:pfam00083  77 KSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYI 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  186 FSLQ-AILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYsLIQKGDEATARQALRRLRGHTDMEAELEDMRAEARAER 264
Cdd:pfam00083 157 FGLGlNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRW-LVEKGRLEEAREVLAKLRGVPDVDRELDEIKDSLEAGQ 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  265 AEGHLSVLHLCALRSLRWQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAahSQYVTVGSGVVNIVMTITSAVLVER 344
Cdd:pfam00083 236 EAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSD--SFLVTIIVGVVNFVFTFIAIFLVDR 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  345 LGRRHLLLAGYGICGSACLVLT-VVLLFQNRVPELSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFMVDGA 423
Cdd:pfam00083 314 FGRRPLLLLGAAGMAICFVILGiVALLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATA 393
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 134053883  424 VHWLTNFIIGFLFPSIQEAIG-AYSFIIFAGICLLTAIYIYVVIPETKGKTFVEINRIF 481
Cdd:pfam00083 394 ANWLANFLIGFLFPIITDAIGlGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDELF 452
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
17-477 3.42e-101

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 312.74  E-value: 3.42e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883   17 GRLQPTLLLATLSAAFGSaFQYGYNLSVVNtphkvfkSFYNETYFERHATFMDGKLML-LLWSCTVSMFPLGGLLGSLLV 95
Cdd:TIGR00879  20 GSTYWKVALLSLIAAIGG-LMFGYDTGVIG-------GALALPAFEFKFTSANSDSYSsSLWGLVVSIFLVGGFIGALFA 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883   96 GLLVDSCGRKGTLLINNIFAIIPAILMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVF 175
Cdd:TIGR00879  92 GWLSDRFGRKKSLLIIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLA 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  176 VIVGVFLAQIFSLQA-ILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYsLIQKGDEATARQALRRLRGHTDMEAELE 254
Cdd:TIGR00879 172 ITFGILVAYGFGSGKvSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRW-LVGKGRVEEARKSLARLRGTSGEDKELL 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  255 DMRAEARAERAEGHLSVLHLCA-----LRSLRWQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGV 329
Cdd:TIGR00879 251 DELELIDIKRSIEKRSVQPSWGslfssTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGA 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  330 VNIVMTITSAVLVERLGRRHLLLAGYGICGSACLVLTVVLLFQ--NRVPELSYLGIICVFAYIAGHSIGPSPVPSVVRTE 407
Cdd:TIGR00879 331 VNFAFTFVAIFLVDRFGRRPLLLIGAAGMAICLFVLGILGASFvtGSSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSE 410
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 134053883  408 IFLQSSRRAAFMVDGAVHWLTNFIIGFLFPSIQEAIG-AYSFIIFAGICLLTAIYIYVVIPETKGKTFVEI 477
Cdd:TIGR00879 411 IFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGvGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
103-473 1.65e-69

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 229.00  E-value: 1.65e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 103 GRKGTLLINNIFAIIPAILMGVskvAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFL 182
Cdd:cd17358   69 GRKRTLLISAIPCILGWLLIAF---AKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILL 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 183 AQifslqaILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYsLIQKGDEATARQALRRLRG-HTDMEAELEDMRAEAR 261
Cdd:cd17358  146 GY------VLGSFLPWRTLALIGAIPPVVFLILLFFIPESPRW-LAKKGREEEAEKSLQFLRGkDADISKEAAEIQEELA 218
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 262 AERAEGHLSVLHLCALRSLRWQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAAHSQyVTVGSGVVNIVMTITSAVL 341
Cdd:cd17358  219 ELEKEAKESSFSDLFQRKYLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGLDPNT-ATIIIGVVQVVGTLVATLL 297
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 342 VERLGRRHLLLAGYGICGSACLVLTVVLLFQNRVP---ELSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAF 418
Cdd:cd17358  298 VDRLGRRPLLLVSAIGMGIGLLALGLYFYLQEHGAllsSVSWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAG 377
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 134053883 419 MVDGAVHWLTNFIIGFLFPSIQEAIGA-YSFIIFAGICLLTAIYIYVVIPETKGKT 473
Cdd:cd17358  378 SLVTLVNWLFAFIVTKTFPFLTLAWGAsGTFWIFAGICGLALVFVLLFVPETKGKS 433
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
30-468 1.35e-66

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 218.98  E-value: 1.35e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  30 AAFGSaFQYGYNLSVVNTPHKVFKSFYNETYFErhatfmdgklmlLLWSCTVSMFPLGGLLGSLLVGLLVDSCGRKGTLL 109
Cdd:cd17315    2 AALGG-LLFGYDLGVINGALLYIAKDLGFGLST------------SLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLL 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 110 INNIFAIIPAILMGVSKvakAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFLAQIFSLQ 189
Cdd:cd17315   69 IAAVLYVIGALLSALAP---NVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLA 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 190 AILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRysliqkgdeatarqalrrlrghtdmeaeledmraearaeraeghl 269
Cdd:cd17315  146 LSLSPPGWWRLMFALAAVPALLQLLLMFFLPESRA--------------------------------------------- 180
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 270 svlhlcalrslrwqlLSIIVLMAG-QQLSGINAINYYADTIYTSAGVEAAhSQYVTVGSGVVNIVMTITSAVLVERLGRR 348
Cdd:cd17315  181 ---------------LLVGVGLQLlQQLTGINAVMYYAPTIFKSAGGGTA-SILASIIVGVVNLLATLVAIRLVDKVGRR 244
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 349 HLLLAGYGICGSACLVLTVVLLFQNRVPELSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFMVDGAVHWLT 428
Cdd:cd17315  245 PLLLIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIF 324
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 134053883 429 NFIIGFLFPSIQEAIG-AYSFIIFAGICLLTAIYIYVVIPE 468
Cdd:cd17315  325 NFIVGLTFLIMVSTIGlAGVFIFFAAVCLLALVFVFFFVPE 365
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
100-468 6.88e-56

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 191.63  E-value: 6.88e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLINNIFAIIPAILMGVSKVAKAFeliVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVG 179
Cdd:cd17359   61 DRFGRRKTLLISAVLFFISALGSAFSPNFTIF---IIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFG 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 180 VFLAQIF------SLQAILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYsLIQKGdeatarqalRRLrghtdmeael 253
Cdd:cd17359  138 QLLAYIVnylianAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRW-LVSKG---------KPI---------- 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 254 edmraearaeraeghlsvlhlcalrslrwqLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGVVNIV 333
Cdd:cd17359  198 ------------------------------LIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFSENAALLQTIGIGVVNVI 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 334 MTITSAVLVERLGRRHLLLAGYGICGSACLVLTVVLLFQNRVPELSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSS 413
Cdd:cd17359  248 FTIIAILLVDKVGRKPLLLIGSIGMAISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRI 327
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 134053883 414 RRAAFMVDGAVHWLTNFIIGFLFPSIQEAIG-AYSFIIFAGICLLTAIYIYVVIPE 468
Cdd:cd17359  328 RGLAMGIAVFFLWIANFLVSLTFPILLAAFGlAFTFLIFAVICVLAFLFVWKFVPE 383
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
54-481 9.60e-49

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 172.82  E-value: 9.60e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  54 SFYNETYFERHATFMDG--KLMLLLWSCTVSMFPLGGLLGSLLVGLLVDSCGRKGTLLINNIFAIIPAILMgVSKVAKAF 131
Cdd:cd17356   22 GILNMKSFQKYFADNTGtyYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQ-VAAIGKWY 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 132 ELIVfSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFLAQIFSLQA-ILGNPAGWPVLLALTGVPAL 210
Cdd:cd17356  101 QLIV-GRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGThKLDGSAQWRIPLGLQIVWGL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 211 LQLLTLPFFPESPRYsliqkgdeatarqaLRRLrghtdmeaeledmraearaeraeghlsvlhlcalrslrwqlLSIIVL 290
Cdd:cd17356  180 LLLIGMFFLPESPRW--------------LYRT-----------------------------------------ILGIML 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 291 MAGQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITSAVLVERLGRRHLLLAGyGICGSACLVLTVVLL 370
Cdd:cd17356  205 QLFQQLTGINYFFYYGTTIFQSTGLTGSSPLLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLIG-AAGMSICLFIYAAVG 283
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 371 FQNRVPELSYLG---------IICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFMVDGAVHWLTNFIIGFLFPSIQE 441
Cdd:cd17356  284 VRYLIPNPQSGTsnksagngmIVFICLFIFSFATTWGPIAWVYVAEVFPLRVRSKGMALATAFNWLWNFLISFFTPFIIG 363
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 134053883 442 AIGAYSFIIFAGICLLTAIYIYVVIPETKGKTFVEINRIF 481
Cdd:cd17356  364 SIGFKYYYIFAGCNLLAFIVVFFFVPETKGLTLEEIDELF 403
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
100-477 1.12e-48

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 172.54  E-value: 1.12e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLINNIFAIIPAILMGVskvAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVG 179
Cdd:cd17362   64 DRLGRRKELILAALLYLVGSLVTGL---APSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLG 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 180 VFLAQIFSlQAILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYSliqkgdeataRQALRRLrghtdmeaeledmrae 259
Cdd:cd17362  141 ILLGYVSG-YAFADVVGGWRYMYGLAAPPALLLGIGMWFLPPSPRWQ----------GNYRKPL---------------- 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 260 araeraeghlsVLHLCalrslrwqllsiivLMAGQQLSGINAINYYADTIYTSAGVEAAHSQY-VTVGSGVVNIVMTITS 338
Cdd:cd17362  194 -----------IIGLG--------------LVLFQQITGQPSVLYYAATIFKSAGFSAASDATlVSVGLGVFKLLMTIVA 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 339 AVLVERLGRRHLLLAGYGICGSACLVLTVVLLFQNRVPE-LSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAA 417
Cdd:cd17362  249 VLLVDKLGRRPLLLGGVSGMVVSLFLLAAYNLFVQMGPAgLAWLSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRGRA 328
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 134053883 418 FMVDGAVHWLTNFIIGFLFPSIQEAIGA-YSFIIFAGICLLTAIYIYVVIPETKGKTFVEI 477
Cdd:cd17362  329 IALAVLVNFGSNALVSLAFLPLQELIGLpGTFLGFGVIGVLALLFIYFTVPETKGLSLEEI 389
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
100-468 4.87e-46

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 164.75  E-value: 4.87e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLINNIFAIIPAILMGVskvAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVG 179
Cdd:cd17360   60 DRFGRRPCILLADALFTIGAIVMAA---APNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGG 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 180 VFLAQIFSLqAILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYsliqkgdeatarqalrrlrghtdmeaeledmrae 259
Cdd:cd17360  137 QFVAYVING-AFSYLPGGWRWMLGLAAVPAVLQFIGLLFLPESPRW---------------------------------- 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 260 araeraeghlsvlhlcalRSLRWQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAAH-SQYVTVGSGVVNIVMTITS 338
Cdd:cd17360  182 ------------------PSTRRALIVGCGLQAFQQFSGINTVMYYSATILQMAGFKDNQnAIWLSLIVAGTNFIFTIVG 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 339 AVLVERLGRRHLLLAGYGICGSACLVLTVvllfqnrvpelsYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAF 418
Cdd:cd17360  244 MYLIDKFGRRKLLLISLFGVIVALVVLAV------------WLALVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGG 311
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 134053883 419 MVDGAVHWLTNFIIGFLFPSIQEAIGAY-SFIIFAGICLLTAIYIYVVIPE 468
Cdd:cd17360  312 GCAAAVNWVFNLLVSQTFLTLTQAIGPYgTFLLFAGLAVLGLIFIYFCVPE 362
xylE PRK10077
D-xylose transporter XylE; Provisional
135-486 1.52e-38

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 146.76  E-value: 1.52e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 135 VFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFLAQIFSLQAILGNPA------GWPVLLALTGVP 208
Cdd:PRK10077 124 VIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYFVNYFIARSGDAswlntdGWRYMFASEAIP 203
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 209 ALLQLLTLPFFPESPRYsLIQKGDEATARQALRRLRGHTDMEAELEDMRAEARAERAEGHlsvlhlcalRSLRWQLLSII 288
Cdd:PRK10077 204 ALLFLMLLYFVPETPRY-LMSRGKQEQAEGILRKIMGNTLATQALQEIKHSLDHGRKTGG---------KLLMFGVGVIV 273
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 289 V---LMAGQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITSAVLVERLGRRHLLLAGYgiCGSACLVL 365
Cdd:PRK10077 274 IgvmLSVFQQFVGINVVLYYAPEIFKTLGASTDIALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQIIGA--LGMAIGMF 351
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 366 TVVLLFQNRVPELsyLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFMVDGAVHWLTNFIIGFLFPSIQEAI-- 443
Cdd:PRK10077 352 SLGTAFYTQAPGI--VALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAIRGKALAIAVAAQWIANYFVSWTFPMMDKNSwl 429
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 134053883 444 -----GAYSFIIFAGICLLTAIYIYVVIPETKGKTFVEINRIFAKRNR 486
Cdd:PRK10077 430 vahfhNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEEMEALWEPETK 477
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
100-477 9.90e-37

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 139.84  E-value: 9.90e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLINNIFAIIPAILMGVskvAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVG 179
Cdd:cd17437   57 DWIGRRYTIALAALIFFVGALLMGV---APNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIG 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 180 VFLAQIFSLqAILGNPA--GWPVLLALTGVPALLQLLTLPFFPESPRYSliqkgdeatarqalrrlrghtdmeaeledmr 257
Cdd:cd17437  134 ILLGYVSNY-AFSGLPLhvGWRLMLGVGAVPSLFLAIGVLAMPESPRWT------------------------------- 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 258 aearaeraeghlsvlhlcalRSLRWQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAAHSQY-VTVGSGVVNIVMTI 336
Cdd:cd17437  182 --------------------PAVRRMLIAALGIHFFQQASGIDAVVLYSPRIFKKAGIKSKDKLLlATVAVGVTKTLFIL 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 337 TSAVLVERLGRRHLLLAGYGICGSACLVLTVVLLFQNRVPELS----YLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQS 412
Cdd:cd17437  242 VATFLLDKVGRRPLLLTSTGGMTLSLTALATSLTFIDRNGGGLtwalVLAITAVCSFVAFFSIGAGPITWVYSSEIFPLR 321
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 134053883 413 SRRAAFMVDGAVHWLTNFIIGFLFPSIQEAIG-AYSFIIFAGICLLTAIYIYVVIPETKGKTFVEI 477
Cdd:cd17437  322 LRAQGASLGVVVNRLMSGTVSMTFLSMSKAITtGGTFFLFAGVAAAAWVFFYFFLPETKGKSLEEI 387
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
100-476 1.86e-36

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 139.63  E-value: 1.86e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLinniFAIIPAIL-MGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIV 178
Cdd:cd17433   66 DRAGRKLSLM----LCSVPFIAgFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVI 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 179 GVFLAQIFSLQailgnpAGWPVLLALTGVPALLQLLTLPFFPESPRYSLIQkGDEATARQALRRLRGhTDMEAELEDMRA 258
Cdd:cd17433  142 GIMGAYLAGLV------LDWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQ-HRRQEAMAALRFLRG-PDQGWEWECIGI 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 259 EARAERAEGHLSvLHLCALRSLRWQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEaaHSQYVTVGSGVVNIVMTITS 338
Cdd:cd17433  214 EQSFHLEEQSFS-LALLKQPGIYKPLIIGVSLMAFQQLTGINAVMFYAETIFEEAKFK--DSSVASVIVAAIQVLFTAVA 290
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 339 AVLVERLGRRHLL-LAGygicgsaclvltVVLLFQNRVPELSYLGIICVFayIAGHSIGPSPVPSVVRTEIFLQSSRRAA 417
Cdd:cd17433  291 ALIMDRAGRKVLLvLSG------------VVMVFSTAAFGWLAVGSMGFF--IAGFAVGWGPIPWLVMSEIFPLHVRGVA 356
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 418 FMVDGAVHWLTNFIIGFLFPSIQEAIGAY-SFIIFAGICLLTAIYIYVVIPETKGKTFVE 476
Cdd:cd17433  357 SGICVLTNWLMAFLVTKEFSSLMEVLSSYgTFWLFSAFCAFSVLFTLFCVPETKGKTLEQ 416
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
103-468 6.82e-36

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 137.77  E-value: 6.82e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 103 GRKGTLLINNIFAIIPAILMGVskvAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFL 182
Cdd:cd17361   79 GRKPSMLIGGVLFLVGAALNAA---AQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILI 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 183 AQIFSLQAILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYSliqkgdeatarqalrrlrghtdmeaeledmraeara 262
Cdd:cd17361  156 ANLINYGTSKIKPNGWRLSLGLAAVPALILLLGSLFLPETPNSP------------------------------------ 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 263 eraeghlsvlhlcalrslrwQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITSAVLV 342
Cdd:cd17361  200 --------------------QLVIAILIPFFQQLTGINVIMFYAPVLFQTLGFGSDASLISAVITGAVNVVSTLVSIYLV 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 343 ERLGRRHLLLAGyGICGSACLVLTVVLLFQ----NRVPELSYLGIICVF--AYIAGHSIGPSPVPSVVRTEIFLQSSRRA 416
Cdd:cd17361  260 DRFGRRFLLLEG-GVQMLASQVAIGILLAVkfgdGGELPKAYAIAVVVLicLYVAAFAWSWGPLGWLVPSEIFPLETRSA 338
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 134053883 417 AFMVDGAVHWLTNFIIGFLFPSIQEAIGAYSFIIFAGICLLTAIYIYVVIPE 468
Cdd:cd17361  339 GQSLTVAVNFLFTFVIAQAFLSMLCAMKFGIFLFFAGWVVVMSLFVYFLLPE 390
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
100-476 1.55e-30

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 123.02  E-value: 1.55e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLINNIFAIIPAILMGVskvAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVG 179
Cdd:cd17434   66 DRLGRKLSIMFSAVPSALGYLLMGS---AQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGACPQIMAVFG 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 180 VFLaqIFSLQAILgnpaGWPVLLALTGVPALLQLLTLPFFPESPRYsLIQKGDEATARQALRRLRG-HTDMEAELE---D 255
Cdd:cd17434  143 SLA--LYALGLLL----PWRWLAVAGEVPVVIMILLLCFMPNSPRF-LISKGKDEKALKALAWLRGpNTDYMTEFEqikD 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 256 MRAEARAERAEGHLSVLHLCAlrslrwQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVeAAHSQYVTVGSGVVNIVMT 335
Cdd:cd17434  216 NIRKQSSRLSWAELKTPSYYK------PILIAVVMRFLQQLTGITPILVYLEPIFHLTAV-ILEPKYDAALVGAVRLLSV 288
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 336 ITSAVLVERLGRRHLLLAGYGICGSACLVLTVVLLfqnrvpelsylgiICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRR 415
Cdd:cd17434  289 AIAASLMDKAGRKILLFTSAFLMFAANLSMGLIPL-------------IAAMLFIMGYAMGWGPITWLLMSEILPLKARG 355
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 134053883 416 AAFMVDGAVHWLTNFIIGFLFPSIQEAIGAYS-FIIFAGICLLTAIYIYVVIPETKGKTFVE 476
Cdd:cd17434  356 VASGLCVVVSWITAFVLTQLFLPVVVTFGLQVpFLFFAAVCAVSIIFTACCVPETKGRTLEQ 417
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
100-477 1.27e-28

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 116.82  E-value: 1.27e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLINNIFAIIPAILMGVSKvakAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVG 179
Cdd:cd17435   61 DRYGRRTAIILTSCLLVLGSLLLVCSV---SYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIG 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 180 VFLAQIFSLqAILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYsliqkgdeatarqalrrlrghtdmeaeledmrae 259
Cdd:cd17435  138 ILLAYISNY-AFANVSNGWKYMFGLVIPLAALQAIAMYFLPPSPRF---------------------------------- 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 260 araeraeghlsvlhLCALRSLRWQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEA-AHSQYVTVGSGVVNIVMTITS 338
Cdd:cd17435  183 --------------LVMKDNMRARLLIGLTLVFFVQITGQPNILFYASTVLKSVGFQSnEAASLASTGVGVVKVVSTIPA 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 339 AVLVERLGRRHLLLAGygicgSACLVLTVVLLFqnrvpelSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAF 418
Cdd:cd17435  249 IFLVDKVGSKTFLCIG-----SSVMAVSLVTMG-------LWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAM 316
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 419 MVDGAVHWLTNFIIGFLFPSIQEAIG-AYSFIIFAGICLLTAIYIYVVIPETKGKTFVEI 477
Cdd:cd17435  317 ALTSSMNWGINLLISLTFLTVTELIGlPWVCFIYTAMSLASLVFVIMFVPETKGCSLEQI 376
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
100-477 2.36e-27

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 113.36  E-value: 2.36e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLINNIFAIIPAILMGVskvAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVG 179
Cdd:cd17436   61 DRHGRRTSILGSNLVLLAGSLILTL---AGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVG 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 180 VFLAqiFSLQAILGN-PAGWPVLLALTGVPALLQLLTLPFFPESPrysliqkgDEATARQALRRlrghtdmeaeledmra 258
Cdd:cd17436  138 ILIS--YALNYFFSNvLTGWRYMFGLAIIPAAIQFASILLLPKKP--------EVLNIKDNMRR---------------- 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 259 earaeraeghlsvlhlcalrslrwQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAAHSQYV-TVGSGVVNIVMTIT 337
Cdd:cd17436  192 ------------------------RTLVGLGLVLFQQFTGQPNVLCYASTIFRSVGFQSNSSAVLaSVGLGVVKVIATLL 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 338 SAVLVERLGRRHLLLAGygicgsaCLVLTVVLLFQNrvpelSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAA 417
Cdd:cd17436  248 AMLFADRAGRRSLLIAG-------CSVMAVSVSGIG-----LWITLLCLMAFVSAFSIGFGPMTWLVLSEIYPADIRGRA 315
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 134053883 418 FMVDGAVHWLTNFIIGFLFPSIQEAIG-AYSFIIFAGICLLTAIYIYVVIPETKGKTFVEI 477
Cdd:cd17436  316 FSFCNSFNWAANLLITLSFLDLIDVIGlSWTFLLYGVVGVAGVVFIYLFVPETKGQSLEEI 376
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
100-460 2.10e-18

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 87.10  E-value: 2.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLINNIFAIIPAILMGVskvAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVG 179
Cdd:cd06174   56 DRFGRRPVLLLGLLLFALGALLFAF---APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVG 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 180 VFLAQIFSLQAILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYSLIQKGDEATARQALRRLRghtdmeaeledmrae 259
Cdd:cd06174  133 GILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLK--------------- 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 260 araeraeghlsvlhlCALRSLRWQLLSIIVLMagQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITSA 339
Cdd:cd06174  198 ---------------RVLKNPGLWLLLLAIFL--VNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLG 260
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 340 VLVERLGRRHLLLAGYGICGSACLVLTVVLLFQnrvpelsYLGIICVFAYIAGHSiGPSPVPSVVRTEIFLQSSRRAAFM 419
Cdd:cd06174  261 LLSDRLIGRKPLLLIGLLLMALGLALLLLAPSL-------LLLLLLLLLLGFGLG-GLLPLSFALIAELFPPEIRGTAFG 332
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 134053883 420 VDGAVHWLTNFIIGFLFPSIQEAIGAYS--FIIFAGICLLTAI 460
Cdd:cd06174  333 LLNTFGFLGGAIGPLLAGFLLAATFGLTgaFLVLAVLLLLAAI 375
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
92-476 1.45e-13

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 72.74  E-value: 1.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883   92 SLLVGLLVDSCGRKGTLLINNIFAIIPAILMGVSKVakaFELIVFSRVVLGV-CAGISYSALPMYLgELAPKNLRGMVGT 170
Cdd:TIGR00898 144 SFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPN---YTVFLVFRLLVGMgIGGIWVQAVVLNT-EFLPKKQRAIVGT 219
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  171 MTEVFVIVGVFLaqiFSLQAILgNPaGWPVLLALTGVPALLQLLTLPFFPESPRYsLIQKGDEATARQALRRLR--GHTD 248
Cdd:TIGR00898 220 LIQVFFSLGLVL---LPLVAYF-IP-DWRWLQLAVSLPTFLFFLLSWFVPESPRW-LISQGRIEEALKILQRIAkiNGKK 293
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  249 MEAELEDMRAEARAERAEGHLSVLHLCALRSLRWQLLSIIVLMAGqqlsgiNAINYYADTIYTSagvEAAHSQYVT-VGS 327
Cdd:TIGR00898 294 LPAEVLSLSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLMMLWFT------TAFSYYGLVLDLG---NLGGNIYLDlFIS 364
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  328 GVVNIVMTITSAVLVERLGRRHLLLAGYGICGSACLVLTVVLlfqnrvPELSYLGIICVFAYIAGHSIGPSPVpSVVRTE 407
Cdd:TIGR00898 365 GLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVP------VDLYFLRTALAVLGKFGITSAFQMV-YLYTAE 437
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 134053883  408 IFLQSSRRAAFMVDGAVHWLTNFIIGFLFpsiqeAIGAYS----FIIFAGICLLTAIYIyVVIPETKGKTFVE 476
Cdd:TIGR00898 438 LYPTVVRNLGVGVCSTMARVGSIISPFLV-----YLGEKWlflpLVLFGGLALLAGILT-LFLPETKGVPLPE 504
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
103-472 3.29e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 71.07  E-value: 3.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 103 GRKGTLLINNIFAIIPAILMGVskvAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFL 182
Cdd:COG2223   68 GPRRVLLIGLLLLGIGLLLLAL---AVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAV 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 183 AQIFSlqAILGNPAGWPVLLALTGVPALL-QLLTLPFFPESPrysliqKGDEATARQALRRLRGhtdmeaeledmraear 261
Cdd:COG2223  145 AAFLA--PLLIAAFGWRNAFLILGILLLVvAVLAWLFLRDPP------AGAAAAAKASLRDQLE---------------- 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 262 aeraeghlsvlhlcALRSLRWQLLSIIVLMAGqqlSGINAINYYADTIYTSA-GVEAAHSQYVTVGSGVVNIVMTITSAV 340
Cdd:COG2223  201 --------------ALRDPRFWLLSLLYFGTF---GSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGW 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 341 LVERLGRRHLLLAGYGICGSACLVLtvvLLFQNRVPelsyLGIICVFAYIAGHSIGPSPVPSVVRtEIFLQSSRRAAFMV 420
Cdd:COG2223  264 LSDRIGGRRVLLIVFALMALGLLLL---ALALGSLW----LFLVLFLLLGLALGGGNGAVFALVP-DIFPTKNAGAVYGL 335
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 134053883 421 DGAVHWLTNFIIGFLFPSIQEAIGAYS--FIIFAGICLLTAIYIYVVIPETKGK 472
Cdd:COG2223  336 VGAAGGLGGFLGPLLFGALLDATGSYTaaFLVFAVLALVALVLTLLLYRRPRRA 389
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
130-470 7.78e-13

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 70.02  E-value: 7.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 130 AFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFLAQI--FSLQAILGNPA----GWPVLLA 203
Cdd:cd17367  100 APIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGvlLVLQHTLGEDQmaawGWRIPFL 179
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 204 LTGVPALLQLLTLPFFPESPRYSLIQKGDEATARqALRRLRGHtdmeaeledmraearaeraeghlsvlhlcalrslRWQ 283
Cdd:cd17367  180 LGGVLAVVVLWLRRGLEETESFEAIAESNEASAG-TLRELRRH----------------------------------PRE 224
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 284 LLSIIVLMAGQQLSginainYYADTIY------TSAGVEAAHSQYVTVGSGVVNIVMTITSAVLVERLGRRHLLLaGYGI 357
Cdd:cd17367  225 LLLVVGLTAGGTLA------FYTWTTYlqkflvNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLL-FFGI 297
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 358 CGSACLVLTVVLLFQNRVPELSYLGIICVFAYIAGH-SIGPspvpsVVRTEIFLQSSRRAAFMVDGAvhwLTNFIIG--- 433
Cdd:cd17367  298 GGTLATVPLLSALDHTDSPYTAFALVLVGLVFLSGYtSINA-----VVKAELFPTHVRALGVGLPYA---LAVAIFGgta 369
                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 134053883 434 -FLFPSIQEAIGAYSFIIFAGICLLTAIYIYVVIPETK 470
Cdd:cd17367  370 pYVALWLKSIGHEWVFFWYVAGLIAISLVVYLRMPETR 407
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
100-368 9.34e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 63.45  E-value: 9.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLINNIFAIIPAILMGVskvAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVG 179
Cdd:COG2814   70 DRFGRRRVLLLGLLLFALGSLLCAL---APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLG 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 180 VFLAQIFSlqAILGNPAGWPVLLALTGVPALLQLLTLPFF-PESPRysliqkGDEATARQALRRLRGHTdmeaeledmra 258
Cdd:COG2814  147 PALGPLLG--GLLADLFGWRWVFLVNAVLALLALLLLLRLlPESRP------AARARLRGSLRELLRRP----------- 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 259 earaeraeghlsvlhlcalrslrwQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITS 338
Cdd:COG2814  208 ------------------------RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLA 263
                        250       260       270
                 ....*....|....*....|....*....|
gi 134053883 339 AVLVERLGRRHLLLAGYGICGSACLVLTVV 368
Cdd:COG2814  264 GRLADRFGRRRLLLIGLLLLALGLLLLALA 293
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
100-479 1.01e-09

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 60.90  E-value: 1.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  100 DSCGRK---GTLLINNIFAIIPAILMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVgtMTEVFV 176
Cdd:TIGR00887  81 DKLGRKrvyGMELIIMIIATVASGLSPGSSPKSVMATLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAM--MAAVFA 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  177 ----------IVGVFLAQIF--SLQAI--LGNPAG---------WPVLLALTGVPALLQLLTLPFFPESPRYSLIQKGDE 233
Cdd:TIGR00887 159 mqgfgilagaIVALIVLAGFkhSLEAAadEASCTGscvpavdymWRILIGFGAVPALLALYFRLTIPETPRYTADVAKDV 238
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  234 ATARQALRR-LRGHTDMEA-ELEDMRAEARAERAEGHLSVLHLCALR--------SLRWQLLSIIvlMAGQQLSG---IN 300
Cdd:TIGR00887 239 EQAASDMSAvLQVKIEAEPdEVEKASTAVEVPKASWSDFFTHFFKWRhgkhllgtAGSWFLLDIA--FYGVNLNQkviLS 316
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  301 AINYyadtIYTSAGVEAAHSQYVTvgsGVVNIVMTITSAV--------LVERLGRRHLLLAGYGICGsaclVLTVVLLFQ 372
Cdd:TIGR00887 317 AIGY----SPPAATNNAYEELYKT---AVGNLIIALAGTVpgywvtvfLVDIIGRKPIQLMGFFILT----VLFFVLGFA 385
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  373 -NRVPELSYLGIICVFAYIAghSIGPSPVPSVVRTEIFLQSSRRAAFMVDGAVHWLTNFIIGFLF--------PSIQEAI 443
Cdd:TIGR00887 386 yNHLSTHGFLAIYVLAQFFA--NFGPNATTFIVPGEVFPTRYRSTAHGISAASGKAGAIIGQFGFlylaqhgdPTKGYPT 463
                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 134053883  444 GAY---SFIIFAGiCLLTAIYIYVVIPETKGKTFVEINR 479
Cdd:TIGR00887 464 GIWmghVLEIFAL-FMFLGILFTLLIPETKGKSLEELSG 501
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
100-469 2.32e-09

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 59.24  E-value: 2.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLINNIFAiipAILMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVG 179
Cdd:cd17371   59 DRFGRVRVLVITILLF---AVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVG 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 180 VFLAQIFSLQAI--LGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYSLIQKGDEATARQALRRLRGHTDMeaeledmr 257
Cdd:cd17371  136 WLLATLLAALLFplLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLRELFSPPL-------- 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 258 aearaeraeghlsvlhlcaLR-SLRWQLLSIIVLMagqqlsGINAINYYADTIYTSA-GVEAAHSQYVTVGSGVVNIVMT 335
Cdd:cd17371  208 -------------------LRtTLLASLLATGALG------GYYGITTWLPSYLTGErGLSFEGSAGYLVVTILGGFLGY 262
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 336 ITSAVLVERLGRRHLLLAGYgICGSACLVLTVVLLFQNRvpELSYLGIICVFAYIAGHSIG----PSPVPSVVRTeiflq 411
Cdd:cd17371  263 LAGGFLADRIGRRNNFALFA-LGSAISILLYFFLPLSPT--LILILGFPLGFFASGPFSGMgaylTELFPTAVRA----- 334
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 134053883 412 SSRRAAFMVDGAVHWLTNFIIGFLFPSIQEAIGAYSFIIFAGICLLTAIYIyvvIPET 469
Cdd:cd17371  335 TAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALL---LPET 389
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
103-245 1.51e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 52.89  E-value: 1.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 103 GRKGTLLINNIFAIIPAILMGVskvAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFL 182
Cdd:COG0477   77 GRKRVLLIGLLLFGLASLLCGL---APSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLAL 153
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 134053883 183 AQIFSlqAILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYSLIQKGDEATARQALRRLRG 245
Cdd:COG0477  154 GPLLG--GLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALA 214
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
100-466 4.02e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 52.22  E-value: 4.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLINNIFAIIPAILMGVSKVakaFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVG 179
Cdd:cd17316   61 DRIGRKKALILTLLLFGLATLLIGLLPT---PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALG 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 180 VFLAQIFS--LQAILGNPAGWPVLLALTGVPALLQLLtlpffpesprysliqkgdeatarqalrrlrghtdmeaeledmr 257
Cdd:cd17316  138 ALLAALVAslLIPLLSGDWGWRILFLIGALPALLALL------------------------------------------- 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 258 aearaeraeghlsvlhlcalrsLRWQLLSIIVLMAGQQLsGINAINYYADTIYTSA-GVEAAHSQYVTVGSGVVNIVMTI 336
Cdd:cd17316  175 ----------------------LRRRTLLLILLWFFISF-GYYGLTTFLPTYLQTVlGLSPATSSLYLLLISLGALVGAL 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 337 TSAVLVERLGRRHLLLAGYGICGsaclvLTVVLLFQNRVPELSYLgIICVFAYIAGHSIGPSPVPSVVrTEIFLQSSRRA 416
Cdd:cd17316  232 IAGLLSDRIGRKKTLVIGLILSG-----ILALPLFYLLSGSPTLL-LLLLFILSFFVGGVWGALYAYL-AELFPTEVRAT 304
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 134053883 417 AFmvdGAVHWLTNFIIGFLFPSIQEAIGAYSFIIFAGICLLTAIYIYVVI 466
Cdd:cd17316  305 GV---GLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIV 351
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
301-469 2.78e-06

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 49.58  E-value: 2.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 301 AINYYADTIYTSAGVEAAHSQY-----VTVGSGVVNIVMTI----TSAVLVERLGRRHLLLAGYGICGsacLVLTVVLLF 371
Cdd:cd17364  214 GQNLFQSTIISAIGFSKTMNAYqelfnIAVGQLIIALAGTVpgywFTVFLIDRIGRKKIQMMGFFGMT---IFLLILAGP 290
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 372 QNRVPELSYLGIIC-VFAYIAGhSIGPSPVPSVVRTEIFLQSSRRAAFMVDGAVHWLTNFIIGFLFPSIQEAIGA-YSFI 449
Cdd:cd17364  291 YDHWKISTIGFFVLyGLTFFFS-NFGPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQNIGVrNVLI 369
                        170       180
                 ....*....|....*....|
gi 134053883 450 IFAGICLLTAIYIYVVIPET 469
Cdd:cd17364  370 ILAGVALLGIILTLLFPEEK 389
MFS_1 pfam07690
Major Facilitator Superfamily;
100-404 3.58e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.95  E-value: 3.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  100 DSCGRKGTLLINNIFAIIPAILMGvskVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVG 179
Cdd:pfam07690  57 DRFGRRRVLLIGLLLFALGLLLLL---FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLG 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  180 VFLAQIFSlqAILGNPAGWPVLLALTGVPALLqLLTLPFFPESPRYSLIQKGDEATARQALRRLRghtdmeaeledmrae 259
Cdd:pfam07690 134 AALGPLLG--GLLASLFGWRAAFLILAILSLL-AAVLLLLPRPPPESKRPKPAEEARLSLIVAWK--------------- 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  260 araeraeghlsvlhlcALRSLRWQLLSIIVLMAGqqlSGINAINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITSA 339
Cdd:pfam07690 196 ----------------ALLRDPVLWLLLALLLFG---FAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLG 256
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 134053883  340 VLVERLGRRHLLLAGYGICGSACLVLTVVLLFQNRVpelsyLGIICVFAYIAGHSIGPSPVPSVV 404
Cdd:pfam07690 257 RLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSL-----WLLLALLLLGFGFGLVFPALNALV 316
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
100-460 2.65e-05

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 46.37  E-value: 2.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLlinnifaIIPAILMGVSKVA------------KAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGM 167
Cdd:cd17369   69 DRIGRKKTL-------VLTLLLMGIATFLigllptyaqigiLAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGF 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 168 VGTMTEVFVIVGVFLAQ--IFSLQAILGNPA----GW--PVLL--ALTGVpALLQLLTLpffPESPRYSLIQKGDEATAR 237
Cdd:cd17369  142 YGSFPQLGAPVGLLLATgvFLLLSALLSDEAflswGWriPFLLsaVLVAV-GLYIRLRL---EETPVFRRAKEAGQVVRA 217
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 238 QALRRLRGHtdmeaeledmraearaeraeghlsvlhlcalrslRWQLLSIIVLMAGQQlsginaINYYADTIY------T 311
Cdd:cd17369  218 PLVEVLRRH----------------------------------WRALLLAIGLRLAEN------VLFYLFTTFalsyatQ 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 312 SAGVEAAHSQYVTVGSGVVNIVMTITSAVLVERLGRRHLLLAgyGICGSACLVLTVVLLFQNRVPELSYLGIICVFAyiA 391
Cdd:cd17369  258 TLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLA--GALLAALFAFPFFWLLDTGSTWLIVLAAVVVLG--V 333
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 134053883 392 GHSIGPSPVPSVVrTEIFLQSSRRAAFmvdGAVHWLTNFIIGFLFPSIQEAIGAYSF------IIFAGICLLTAI 460
Cdd:cd17369  334 LHGMMYGPQAAFL-AELFPTRVRYTGA---SLGYQLGAILGGGFAPLIATALVAATGswwpvaLYLAALAVISLV 404
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
144-486 6.66e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 45.28  E-value: 6.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 144 CAGISYSALPmylGELAP-KNLRGMVGTMTEVFVIVGVFLAQIFS--LQAILG--NPAGWPVLLALTGVPALL-QLLTLP 217
Cdd:COG2211  126 LVNIPYSALG---AELTPdYEERTRLSSWRFAFAGLGGLLASVLPppLVAAFGgdAALGYRLTALIFAVLGLLaFLLTFF 202
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 218 FFPESPRysliQKGDEATARQALRRLRGHtdmeaeledmraearaeraeghlsvlhlcalRSLRWQLLSIIVLMAGQQLS 297
Cdd:COG2211  203 GTKERPV----PEEEKVSLKESLKALLKN-------------------------------RPFLLLLLAYLLFFLALALV 247
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 298 GINAINYYADTIytsaGVEAAHSQYVTVGSGVVNIVMTITSAVLVERLGRRHLLLAGYGICGSACLVLtvvLLFQNRVPE 377
Cdd:COG2211  248 AALLLYYFKYVL----GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL---FFLGPGNLW 320
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 378 LSYLGIICVFAYIAGHSIGPSP-VPSVV-RTEIFLQSSRRAAFMvdGAVHWLTNF---IIGFLFPSIQEAIG-------- 444
Cdd:COG2211  321 LLLVLAALAGIGLGAILVLPWAmLADVVdYDEWKTGRRREGLYF--GIFTFAIKLgqaLAGALAGLLLALFGyvagaaqs 398
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 134053883 445 -------AYSFIIFAGICLLTAIYIYVVIPETKGKTFVEINRIFAKRNR 486
Cdd:COG2211  399 psaltgiRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAARRAA 447
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
100-369 7.50e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 44.88  E-value: 7.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLINNIFAIIPAILMGVSKvakAFELIVFSRVVLGV-CAGISYSALpMYLGELAPKNLRGMVGTMTEVFVIV 178
Cdd:cd17317   50 DRFGRRPVLLLGLVLQIVCGVLSAFSP---SYELFLVLRFLVGVtSAGIFTVGF-VLGMEIVGPKYRSFVGILFGLFWAL 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 179 GVFLaqiFSLQAILGNPagWPVLLALTGVPALLQLLTLPFFPesprysliqkgdeatarqalrrlrghtdmeaeledmra 258
Cdd:cd17317  126 GYML---LALLAYLIRD--WRWLQLAISLPGLLFLLLLWWLP-------------------------------------- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 259 earaeraeGHLSVLHLCalrslrWqllsiivlmagqqlsGINAINYYADTIYTSAGveaAHSQYV-TVGSGVVNIVMTIT 337
Cdd:cd17317  163 --------RRTIIVGLI------W---------------FVTSLVYYGLSLNSSNL---GGNLYLnFFLSGLVEIPAYFL 210
                        250       260       270
                 ....*....|....*....|....*....|..
gi 134053883 338 SAVLVERLGRRHLLLAGYGICGSACLVLTVVL 369
Cdd:cd17317  211 ALLLLDRLGRRWTLSGSLLLAGLACLVTALLP 242
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
100-470 8.49e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 44.86  E-value: 8.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLINNIFAIIPAILMGVskvAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVG 179
Cdd:COG2271   70 DRFGRRRVLAIGLLLWGLATLLFGF---ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLG 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 180 VFLAQIFSlqAILGNPAGWPVLLALTGVPALLqlltlpffpesprysliqkgdeatarqalrrlrghtdmeaeledmrae 259
Cdd:COG2271  147 GALAPPLL--GWLLAAFGWRAAFLILGLPGLL------------------------------------------------ 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 260 araeraeghLSVLHLcalrslrWQLLSIIVLMAGqqlsGINAINYYADTIYTSA-GVEAAHSQYVTVGSGVVNIVMTITS 338
Cdd:COG2271  177 ---------LALLRF-------WLLALAYFLVYF----ALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLG 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 339 AVLVERLGRRHLLLAGYGicgsaCLVLTVVLLFQNRVPELsYLGIICVFAYIAGHSIGPSPVPSVVrTEIFLQSSRRAAF 418
Cdd:COG2271  237 GWLSDRLGRRRKLVLAIG-----LLLAALALLLLALLPSP-ALAIALLFLAGFGLGGAFGLLWALA-AELFPKKARGTAS 309
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 134053883 419 MVDGAVHWLTNFIIGFLFPSIQEAIG-AYSFIIFAGICLLTAIYIYVVIPETK 470
Cdd:COG2271  310 GLVNTFGFLGGALGPLLVGYLLDATGyQAAFLLLAALALLAALLALLLLRETR 362
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
133-460 9.19e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 44.86  E-value: 9.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 133 LIVFSRVVLGVCAGISYSALPMYLGELAPKNlrgmVGTMTEVFVIVGVFLAQIFSLQAI-LGNPAGWPVLLALTGVPALL 211
Cdd:COG2807  108 LLLAGTALIGAGIAVGNVLLPGLIKRWFPDR----VGLMTGLYTAAMGLGAALAAGLTVpLAAALGWRGALAVWALLALL 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 212 QLL-TLPFFPESPRysliqKGDEATARQALRRLrghtdmeaeledmraearaeraeghlsvlhlcaLRSLR-WQLlsiiV 289
Cdd:COG2807  184 ALLlWLPLLRRRPA-----AAAAAPAAASLRSL---------------------------------WRSPLaWLL----T 221
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 290 LMAGQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITSAVLVERLGRRHLLLAGygiCGSACLVLTVVL 369
Cdd:COG2807  222 LFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLL---LGLLGLAGLLGL 298
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 370 LFqnrVPELSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFMVdgAVHWLTNFIIGFLFPSIQEAIGAY--S 447
Cdd:COG2807  299 LL---APGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQ--SVGYLLAALGPLLVGALHDATGSWtaA 373
                        330
                 ....*....|...
gi 134053883 448 FIIFAGICLLTAI 460
Cdd:COG2807  374 LLLLAALAVLMLV 386
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
100-238 1.58e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 43.88  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  100 DSCGRKGTLLINnifAIIPAILMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVG 179
Cdd:TIGR00895  77 DRIGRRRVLLWS---ILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIG 153
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  180 VFLAQIFSlqAILGNPAGWPVLLALTGV-PALLQLLTLPFFPESPRYsLIQKGDEATARQ 238
Cdd:TIGR00895 154 AAVGGFLA--GWLIPVFGWRSLFYVGGIaPLLLLLLLMRFLPESIDF-LVSKRPETVRRI 210
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
100-234 2.29e-04

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 43.76  E-value: 2.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLINnifAIIPAILMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVG 179
Cdd:cd17438   59 DKLGRKRCLIIS---LAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIG 135
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 134053883 180 VFLAQIFSLQAI----LGNPAG-------WPVLLALTGVPALLQLLTLPFFPESPRYSL-IQKGDEA 234
Cdd:cd17438  136 GLYASAMAWSIIphygWGFSMGtnyhfhsWRVFVIICALPCIASIIALKFMPESPRFLLeMGKHDEA 202
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
100-243 2.59e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 43.38  E-value: 2.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLINNIFAIIPAIlmgVSKVAKAFELIVFSRVVLGVCAGISYSALPMyLGELAPKNLRGMVGTMTEVFVIVG 179
Cdd:cd06179   57 DLFGRRWFFIGGNLLGVVGSI---VAGTAKSVNMLIGGQALIGIGAGTQGLGAAV-ASELVPNKYRGLVQGVVNLVASPG 132
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 134053883 180 VFLAQIFSLQAILGNPAGW-PVLLALTGVPALLQLLTLPF-FPESPRYSLiqkgdEATARQALRRL 243
Cdd:cd06179  133 SALGPLIAGALVEANAAGWrWIFYINAIFNALALILLFFFyHPPPRPQLH-----GSSTRQKLKRL 193
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
100-398 2.75e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 43.31  E-value: 2.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLINNIFAIIPAILMGVskvAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGM-VGTMtevfvIV 178
Cdd:cd17324   59 DRIERRRLLLVLLLLFILGNLLAAL---APSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRaIGLV-----FS 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 179 GVFLAQIFS--LQAILGNPAGW-PVLLALTGVPALLQLLTLPFFPESPrysliqkGDEATARQALRRLRGHtdmeaeled 255
Cdd:cd17324  131 GLTLGLVLGrpLGGLLGQLLGWrAAFLAIAVLALLAALLLWRLLPSLP-------PKKPGSLGLLSSLLLL--------- 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 256 mraearaeraeghlsvlhlcaLRSLR-WQLLSIIVLMAGQQLSGINAINYY-ADTIYTSAGVEAAhsqyVTVGSGVVNIV 333
Cdd:cd17324  195 ---------------------LRNPRlRLAYLITFLLFGGFFALYTYLAPFlTDVPGFSSSAIIG----LLLLFGVAGVV 249
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 134053883 334 MTITSAVLVERLGRRHLLLAgygicGSACLVLTVVLLFQNRVPELSYLGIICV-FAYIAGHSIGPS 398
Cdd:cd17324  250 GSPLAGRLADRGGRRALLIA-----LLLLAAALLLLTLLGPSPLLLLVGLVLWgLGFFAAHSALQT 310
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
278-470 3.52e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 42.65  E-value: 3.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 278 RSLRWQLLSIIVLMAGQQLSGIN--AINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITSAVLVERLGRRHLLLAGY 355
Cdd:COG2814    3 ATPRRRWLALLALALGAFLSGLGigIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 356 GICGSACLVLTVvllfqnrVPELSYLgIICVFAYIAGHSIGPSPVPSVVRtEIFLQSSRRAAFMVDGAVHWLTNFIIGFL 435
Cdd:COG2814   83 LLFALGSLLCAL-------APSLWLL-LAARFLQGLGAGALFPAALALIA-DLVPPERRGRALGLLGAGLGLGPALGPLL 153
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 134053883 436 FPSIQEAIG-AYSFIIFAGICLLTAIYIYVVIPETK 470
Cdd:COG2814  154 GGLLADLFGwRWVFLVNAVLALLALLLLLRLLPESR 189
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
92-220 8.13e-04

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 41.41  E-value: 8.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  92 SLLVGLLVDSCGRKGTLLINNIFAIIPAILMGVSkvaKAFELIVFSRVVLGV-CAGISYSALpMYLGELAPKNLRGMVGT 170
Cdd:cd17317   42 SLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFS---PSYELFLVLRFLVGVtSAGIFTVGF-VLGMEIVGPKYRSFVGI 117
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 134053883 171 MTEVFVIVGVFLaqiFSLQAILGNPagWPVLLALTGVPALLQLLTLPFFP 220
Cdd:cd17317  118 LFGLFWALGYML---LALLAYLIRD--WRWLQLAISLPGLLFLLLLWWLP 162
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
100-234 8.65e-04

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 41.89  E-value: 8.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883  100 DSCGRKGTLLI----NNIFAIIPAILMGvskvakaFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVF 175
Cdd:TIGR01299 227 DKLGRKQCLLIclsvNGFFAFFSSFVQG-------YGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMF 299
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 134053883  176 VIVGVFLAQIFSLQAI--------LGNP---AGWPVLLALTGVPALLQLLTLPFFPESPRYSL-IQKGDEA 234
Cdd:TIGR01299 300 WMIGGIYAAAMAWAIIphygwsfqMGSAyqfHSWRVFVIVCAFPCVFAIGALTFMPESPRFFLeNGKHDEA 370
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
103-466 1.31e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.02  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 103 GRKGTLLINNIFAIIPAILMGVskvAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMV-GTMTEVFVI---- 177
Cdd:cd17325   59 GRKRLLLLGLLLLAVSTLLFAF---ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAmGIFSSAIGLgfli 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 178 ---VGVFLAQIFSLQAilgnpagwpVLLALTGVPALLQLLTLPFFPESPRYSLIQKGDEATARQALRRLRGHtdmeaele 254
Cdd:cd17325  136 gplLGGLLADALGYRA---------PFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRD-------- 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 255 dmraearaeraeghlsvlhlcalRSLRWQLLSIIVLMAGqqLSGINA-INYYADTIYtsaGVEAAHSQYVTVGSGVVNIV 333
Cdd:cd17325  199 -----------------------RRLLALFLAIFVLAFA--FGALEPfLPLYAAELG---GLSPAQIGLLFGAQGLASAL 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 334 MTITSAVLVERLGRRHLLLAGYGICGSACLVLTVvllfqnrVPELSYLGIICVFAYIAGHSIGPSPVPSVvrTEIFLQSS 413
Cdd:cd17325  251 SQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL-------ATSFWLLLLLLALLGLGLGLVFPATLALL--ADIVPPEG 321
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 134053883 414 RRAAFMVDGAVHWLTNFIIGFLFPSIQEAIG-AYSFIIFAGICLLTAIYIYVVI 466
Cdd:cd17325  322 RGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGfATPFLAAAALLLLAAVLFLLLR 375
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
100-225 2.18e-03

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 40.57  E-value: 2.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLINNIFAIIPAILmgvSKVAKAFELIVFSRVVLGVCAGISYSALPMYlGELAPKNLRGMVGTMTEVFVIVG 179
Cdd:cd17441   59 DQYGRKTGLKISVLWTLYYGIL---SAFAPIYSWILVLRGLVGFGIGGVPQSVTLY-AEFLPMKSRAKCILLIEVFWALG 134
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 134053883 180 -VFLAqifsLQAILGNPA-GWPVLLALTGVPALLQLLTLPFFPESPRY 225
Cdd:cd17441  135 tVFEV----LLAVFVMPTlGWRWLLILSALPLLIFAVLCFWLPESARY 178
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
100-234 6.17e-03

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 39.13  E-value: 6.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLI----NNIFAIIPAILMGvskvakaFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVF 175
Cdd:cd17440   59 DKVGRRQSLLIcmsvNGFFAFLSSFVQG-------YGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMF 131
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 134053883 176 VIVGVFLAQIFSLQAI--------LGNP---AGWPVLLALTGVPALLQLLTLPFFPESPRYSL-IQKGDEA 234
Cdd:cd17440  132 WMIGGIYASAMAWAIIphygwsfsMGSAyqfHSWRVFVIVCALPCVSSVVALTFMPESPRFLLeVGKHDEA 202
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
100-220 7.06e-03

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 38.49  E-value: 7.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134053883 100 DSCGRKGTLLINNIFAIIPAILMGVSKvakAFELIVFSRVVLGV-CAGISYSALPMyLGELAPKNLRGMVGTMTEVFVIV 178
Cdd:cd17378   59 SSLGRKNLLFLSCLLMALSGIATAFSP---NYWVYAFLRFLTGFgRSGIGTCALVL-ATEPVGPKWRGQVGMSTFFFFVL 134
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 134053883 179 GVFlaqIFSLQAILgNPAGWPVLLALTGVPALLQLLTLPFFP 220
Cdd:cd17378  135 GFM---SLPGIAYL-NGSSWRVLYFWTSIPALIYCILVYLFA 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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