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Conserved domains on  [gi|6707761|sp|O00526|]
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RecName: Full=Uroplakin-2; Short=UP2; AltName: Full=Uroplakin II; Short=UPII; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Uroplakin_II super family cl47967
Uroplakin II; This family contains uroplakin II, which is approximately 180 residues long and ...
 21-184 8.16e-97

Uroplakin II; This family contains uroplakin II, which is approximately 180 residues long and seems to be restricted to mammals. Uroplakin II is an integral membrane protein, and is one of the components of the apical plaques of mammalian urothelium formed by the asymmetric unit membrane - this is believed to play a role in strengthening the urothelial apical surface to prevent the cells from rupturing during bladder distension.


The actual alignment was detected with superfamily member pfam07353:

Pssm-ID: 462150  Cd Length: 165  Bit Score: 277.67  E-value: 8.16e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6707761     21 SPGAADFNISSLSGLLSPALTESLLVALPPCHLTGGNATLMVRRANDSKVVTSSFVVPPCRGRRELVSVVDSGAGFTVTR 100
Cdd:pfam07353   2 ALGSADFNISSLSGLLSPALAESLLIALPPCHLTGGKASLMVRRANDSAGMKHDFTVPPCRARRDLVSVVDNGGGFSITR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6707761    101 LSAYQVTNLVPGTKFYISYLVKKGTATESSREIPMSTLPRRNMESIGLGMARTGGMVVITVLLSVAMFLLVLGFIIALAL 180
Cdd:pfam07353  82 LSAYQVTNLIPGTKYFISYRVEKGTATESSNETPMATLPRKKMESIGLGMARTGGMIVITVLLSVAMFLLVVGLIVALAL 161


                  ....
gi 6707761    181 GSRK 184
Cdd:pfam07353 162 DAHK 165
 
Name Accession Description Interval E-value
Uroplakin_II pfam07353
Uroplakin II; This family contains uroplakin II, which is approximately 180 residues long and ...
 21-184 8.16e-97

Uroplakin II; This family contains uroplakin II, which is approximately 180 residues long and seems to be restricted to mammals. Uroplakin II is an integral membrane protein, and is one of the components of the apical plaques of mammalian urothelium formed by the asymmetric unit membrane - this is believed to play a role in strengthening the urothelial apical surface to prevent the cells from rupturing during bladder distension.


Pssm-ID: 462150  Cd Length: 165  Bit Score: 277.67  E-value: 8.16e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6707761     21 SPGAADFNISSLSGLLSPALTESLLVALPPCHLTGGNATLMVRRANDSKVVTSSFVVPPCRGRRELVSVVDSGAGFTVTR 100
Cdd:pfam07353   2 ALGSADFNISSLSGLLSPALAESLLIALPPCHLTGGKASLMVRRANDSAGMKHDFTVPPCRARRDLVSVVDNGGGFSITR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6707761    101 LSAYQVTNLVPGTKFYISYLVKKGTATESSREIPMSTLPRRNMESIGLGMARTGGMVVITVLLSVAMFLLVLGFIIALAL 180
Cdd:pfam07353  82 LSAYQVTNLIPGTKYFISYRVEKGTATESSNETPMATLPRKKMESIGLGMARTGGMIVITVLLSVAMFLLVVGLIVALAL 161


                  ....
gi 6707761    181 GSRK 184
Cdd:pfam07353 162 DAHK 165
UP_II cd09967
Uroplakin II; Uroplakin II, the dimerization partner of uroplakin Ia, is a member of the ...
 23-176 1.03e-78

Uroplakin II; Uroplakin II, the dimerization partner of uroplakin Ia, is a member of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197376  Cd Length: 165  Bit Score: 231.73  E-value: 1.03e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6707761   23 GAADFNISSLSGLLSPALTESLLVALPPCHLTGGNATL--MVRRANDSKVVTSSFVVPPCRGRRELVSVVDSGAGFTVTR 100
Cdd:cd09967  12 GAADFNISSLSGVLTPALTESLLVALPPCHLTGQNVTLelMNRRANDSKVVKSSFVVPPCRGRRDIVSVVDSGSGFTVTR 91

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6707761  101 LSAYQVTNLVPGTKFYISYLVKKGtaTESSREIPMSTLPRRNMESIGLGMARTGGMVVITVLLSVAMFLLVLGFII 176
Cdd:cd09967  92 NSGYQVTNLTPGTKYYISYLVGKG--TESSREIPMSTLPRKNMNSIGLGMARSGGMVVITVLLSVAMFLLLVGLIF 165
 
Name Accession Description Interval E-value
Uroplakin_II pfam07353
Uroplakin II; This family contains uroplakin II, which is approximately 180 residues long and ...
 21-184 8.16e-97

Uroplakin II; This family contains uroplakin II, which is approximately 180 residues long and seems to be restricted to mammals. Uroplakin II is an integral membrane protein, and is one of the components of the apical plaques of mammalian urothelium formed by the asymmetric unit membrane - this is believed to play a role in strengthening the urothelial apical surface to prevent the cells from rupturing during bladder distension.


Pssm-ID: 462150  Cd Length: 165  Bit Score: 277.67  E-value: 8.16e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6707761     21 SPGAADFNISSLSGLLSPALTESLLVALPPCHLTGGNATLMVRRANDSKVVTSSFVVPPCRGRRELVSVVDSGAGFTVTR 100
Cdd:pfam07353   2 ALGSADFNISSLSGLLSPALAESLLIALPPCHLTGGKASLMVRRANDSAGMKHDFTVPPCRARRDLVSVVDNGGGFSITR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6707761    101 LSAYQVTNLVPGTKFYISYLVKKGTATESSREIPMSTLPRRNMESIGLGMARTGGMVVITVLLSVAMFLLVLGFIIALAL 180
Cdd:pfam07353  82 LSAYQVTNLIPGTKYFISYRVEKGTATESSNETPMATLPRKKMESIGLGMARTGGMIVITVLLSVAMFLLVVGLIVALAL 161


                  ....
gi 6707761    181 GSRK 184
Cdd:pfam07353 162 DAHK 165
UP_II cd09967
Uroplakin II; Uroplakin II, the dimerization partner of uroplakin Ia, is a member of the ...
 23-176 1.03e-78

Uroplakin II; Uroplakin II, the dimerization partner of uroplakin Ia, is a member of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197376  Cd Length: 165  Bit Score: 231.73  E-value: 1.03e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6707761   23 GAADFNISSLSGLLSPALTESLLVALPPCHLTGGNATL--MVRRANDSKVVTSSFVVPPCRGRRELVSVVDSGAGFTVTR 100
Cdd:cd09967  12 GAADFNISSLSGVLTPALTESLLVALPPCHLTGQNVTLelMNRRANDSKVVKSSFVVPPCRGRRDIVSVVDSGSGFTVTR 91

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6707761  101 LSAYQVTNLVPGTKFYISYLVKKGtaTESSREIPMSTLPRRNMESIGLGMARTGGMVVITVLLSVAMFLLVLGFII 176
Cdd:cd09967  92 NSGYQVTNLTPGTKYYISYLVGKG--TESSREIPMSTLPRKNMNSIGLGMARSGGMVVITVLLSVAMFLLLVGLIF 165
UP_III_II cd09966
Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with ...
 21-176 2.21e-52

Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains separating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers; six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197375  Cd Length: 181  Bit Score: 165.29  E-value: 2.21e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6707761   21 SPGAADFNISSLSGLLSPALTE-------SLLVALPPCHLTGGNATL--------MVRRANDSKVVTSSFVVPPCRGRRE 85
Cdd:cd09966  10 STGAGNPTLSTFTLEQPPCMFDssstddvWLVVALPNATLAFQNVTLstdistylTFTTGNYYKTLRASFDLPPCRNRRD 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6707761   86 LVSVVDSGAGFTVTRLSAYQVTNLVPGTKFYISYLVKKGtaTESSREIPMSTLPRRNMESIG---LGMARTGGMVVITVL 162
Cdd:cd09966  90 IVSAYVLRVGNTTTCLSGYCNTPLPGPGPYRVKYLVMNG--SGPSAQTEWSTPIRLNQNKIYsttWPGARSGGMIVITVI 167

                       170
                ....*....|....
gi 6707761  163 LSVAMFLLVLGFII 176
Cdd:cd09966 168 LSVLMFLLLVALIA 181
UP_III cd09968
Uroplakin III; Uroplakin IIIa and IIIb, the dimerization partners of uroplakin Ib, are a ...
 151-176 1.09e-04

Uroplakin III; Uroplakin IIIa and IIIb, the dimerization partners of uroplakin Ib, are a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197377  Cd Length: 187  Bit Score: 40.83  E-value: 1.09e-04
                        10        20
                ....*....|....*....|....*.
gi 6707761  151 ARTGGMVVITVLLSVAMFLLVLGFII 176
Cdd:cd09968 162 RRSGGMIVITSILSVLLALLLLALLA 187
UP_IIIb cd09969
Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is ...
 151-176 6.39e-03

Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197378  Cd Length: 184  Bit Score: 35.83  E-value: 6.39e-03
                        10        20
                ....*....|....*....|....*.
gi 6707761  151 ARTGGMVVITVLLSVAMFLLVLGFII 176
Cdd:cd09969 159 RRSGGMIVITTILSVLLALLLLALLA 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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