|
Name |
Accession |
Description |
Interval |
E-value |
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
192-1087 |
4.90e-168 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 513.72 E-value: 4.90e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 192 ARTYPFTLDPFQAVSIACIERQESVLVSAHTSAGKTVVAEYAVAQSLRDKQRVIYTSPIKALSNQKYRELLAEFG--DVG 269
Cdd:COG4581 19 AEERGFELDPFQEEAILALEAGRSVLVAAPTGSGKTLVAEFAIFLALARGRRSFYTAPIKALSNQKFFDLVERFGaeNVG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 270 LMTGDVTINPDATCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDKERGVVWEETIILLPDKSHFVFLSATIPNAM 349
Cdd:COG4581 99 LLTGDASVNPDAPIVVMTTEILRNMLYREGADLEDVGVVVMDEFHYLADPDRGWVWEEPIIHLPARVQLVLLSATVGNAE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 350 QFAEWITKIhRQPCHVVYTDFRPTPL-QHYLFPSGsdgihlvvdeksnfreenfqramsaLMEKQGDDPaamatkgnakk 428
Cdd:COG4581 179 EFAEWLTRV-RGETAVVVSEERPVPLeFHYLVTPR-------------------------LFPLFRVNP----------- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 429 gktgkgGVKGPSDIYKIVKMIMVKNYNPVIVFSFSKRECEALALQMSKLDMNDQTERDLVTTIFNNAvnqlsEKDRELPQ 508
Cdd:COG4581 222 ------ELLRPPSRHEVIEELDRGGLLPAIVFIFSRRGCDEAAQQLLSARLTTKEERAEIREAIDEF-----AEDFSVLF 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 509 IEHILPLLRRGIGIHHSGLLPILKEVIEILFQEGLLKVLFATETFSIGLNMPAKTVVFTNVRKFDGKTFRWISGGEYIQM 588
Cdd:COG4581 291 GKTLSRLLRRGIAVHHAGMLPKYRRLVEELFQAGLLKVVFATDTLAVGINMPARTVVFTKLSKFDGERHRPLTAREFHQI 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 589 SGRAGRRGLDDRGIVILMIDEKMDPPVAKSMLKGEADRLDSAFHLSYNMILNLLRVEGISP-EFMLERCFFQFQNSLEVP 667
Cdd:COG4581 371 AGRAGRRGIDTEGHVVVLAPEHDDPKKFARLASARPEPLRSSFRPSYNMVLNLLARPGLERaRELLEDSFAQFQADRSVV 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 668 KLEAKLEESQQ---HYDSFTILDERPLEEYHTLKTQLERYRTDVRtvvnhpnfclsflqggrlvrvkvgnedfdwgvvvn 744
Cdd:COG4581 451 GLARRARELERalaGVVERLACDLGDLQEYFALRQPLSPLEALER----------------------------------- 495
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 745 vskrplpkgQSNEYLpqesyivhtlvmvasdtgplrirsghlpevhppaaedkgkFEVVPFLLSSLDGiahirvflPNDL 824
Cdd:COG4581 496 ---------ESPAYA----------------------------------------LDVVSVPEATLED--------PRPV 518
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 825 KSQGQKLTVGKALSEVKRRfpegitlldpvenmnikeptfIKLMKKVNILESRLLSNPLHNFSeLEEKYAEYLRKLALLE 904
Cdd:COG4581 519 LLAQDRRARGEAAAAMKAA---------------------IEYDERMERLEEVLRPHPLHECP-LERAFELYRETHPWVR 576
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 905 EVKDLKKKLskARSIMQLDElnsrkrVLRRLGFtTSDDVIEVKGRVACEISSgdgllLTELIFNGMFNDLTPEQCAALLS 984
Cdd:COG4581 577 DIELRPKSV--ARDFDRFCE------LLREYGY-LDDLTLTSEGLLLRYLYD-----AAEALRQGVPDDLDPEELAALIS 642
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 985 CLVF---QEKSEVENQRMKEELAGPLKILQEMARRIAKVskESKQELNEEEYvnsfkpslmEVVYAWAHGASFAQICKMT 1061
Cdd:COG4581 643 WLVEevrRVDSSEWERLPSPANRRAFVLVNALFRRLELL--ERRHGLPELDP---------GLAGAWASGADLAEVLDAT 711
|
890 900 910
....*....|....*....|....*....|...
gi 3287946 1062 DVYEGSLIRMFRR-------LEELIRQMVDAAK 1087
Cdd:COG4581 712 DLDAGDFVRWVRQvidpdpeLRRTARAAVDLIR 744
|
|
| DEXHc_Mtr4-like |
cd18024 |
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or ... |
167-371 |
3.61e-163 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or SKIV2L2) is a type II DEAD box helicase that plays a role in the processing of structured RNAs, including the maturation of 5.8S ribosomal RNA (rRNA)and is part of the TRAMP complex that is involved in exosome-mediated degradation of aberrant RNAs. Mtr4 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350782 [Multi-domain] Cd Length: 205 Bit Score: 480.40 E-value: 3.61e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 167 VRHQVSIPPNYDYVPISKHKSPIPPARTYPFTLDPFQAVSIACIERQESVLVSAHTSAGKTVVAEYAVAQSLRDKQRVIY 246
Cdd:cd18024 1 CTHEVALPPDYDYTPISAHKPPGNPARTYPFTLDPFQKTAIACIERNESVLVSAHTSAGKTVVAEYAIAQSLRDKQRVIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 247 TSPIKALSNQKYRELLAEFGDVGLMTGDVTINPDATCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDKERGVVWE 326
Cdd:cd18024 81 TSPIKALSNQKYRELQEEFGDVGLMTGDVTINPNASCLVMTTEILRSMLYRGSEIMREVAWVIFDEIHYMRDKERGVVWE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 3287946 327 ETIILLPDKSHFVFLSATIPNAMQFAEWITKIHRQPCHVVYTDFR 371
Cdd:cd18024 161 ETIILLPDKVRYVFLSATIPNARQFAEWICKIHKQPCHVVYTDYR 205
|
|
| rRNA_proc-arch |
pfam13234 |
rRNA-processing arch domain; Mtr4 is the essential RNA helicase, and is an exosome-activating ... |
650-915 |
4.27e-99 |
|
rRNA-processing arch domain; Mtr4 is the essential RNA helicase, and is an exosome-activating cofactor. This arch domain is carried in Mtr4 and Ski2 (the cytosolic homolog of Mtr4). The arch domain is required for proper 5.8S rRNA processing, and appears to function independently of canonical helicase activity.
Pssm-ID: 463813 Cd Length: 267 Bit Score: 314.60 E-value: 4.27e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 650 EFMLERCFFQFQNSLEVPKLEAKLEESQQHYDSFTILDERPLEEYHTLKTQLERYRTDVRTVVNHPNFCLSFLQGGRLVR 729
Cdd:pfam13234 1 EYMLKRSFSQFQNQASLPELEKKLKELEKELASIKIPDEEDIKEYYDLRQQLEKLNEDIREVILHPPYGLPFLQPGRLVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 730 VKV-GNEDFDWGVVVNVSKRplpKGQSNEYLPQESYIVHTLVMVASDTGPLRIRSGHLP---EVHPPAAEDKGKFEVVPF 805
Cdd:pfam13234 81 VKDnGDQDFGWGVVVNFKKR---KKNGKAEPPQESYIVDVLLVLALVSSPEDLDKFNDVnpeGFRPAPPGEKGEMEVVPV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 806 LLSSLDGIAHIRVFLPNDLKSQGQKLTVGKALSEVKRRFPEGITLLDPVENMNIKEPTFIKLMKKVNILESRLLSNPLHN 885
Cdd:pfam13234 158 PLSDIEAISSVRLKLPKDLRPAEAREAVLKALQELKRRFPDGIPLLDPIEDMKIKDDEFKELLRKIEVLESRLESHPLHK 237
|
250 260 270
....*....|....*....|....*....|
gi 3287946 886 FSELEEKYAEYLRKLALLEEVKDLKKKLSK 915
Cdd:pfam13234 238 SPRLEELYALYHEKVELQEEIKELKKEISD 267
|
|
| DEXHc_SKIV2L |
cd18027 |
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also ... |
191-368 |
4.19e-87 |
|
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also called SKI2 or DHX13) plays a role in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. SKIV2L belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350785 [Multi-domain] Cd Length: 179 Bit Score: 278.76 E-value: 4.19e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 191 PARTYPFTLDPFQAVSIACIERQESVLVSAHTSAGKTVVAEYAVAQSLRDKQRVIYTSPIKALSNQKYRELLAEFGDVGL 270
Cdd:cd18027 1 PAFKWPFELDVFQKQAILHLEAGDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFKNTFGDVGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 271 MTGDVTINPDATCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDKERGVVWEETIILLPDKSHFVFLSATIPNAMQ 350
Cdd:cd18027 81 ITGDVQLNPEASCLIMTTEILRSMLYNGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPDHVSIILLSATVPNTVE 160
|
170
....*....|....*...
gi 3287946 351 FAEWITKIHRQPCHVVYT 368
Cdd:cd18027 161 FADWIGRIKKKNIYVIST 178
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
192-676 |
2.11e-74 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 256.36 E-value: 2.11e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 192 ARTYPFTLDPFQAVSI-ACIERQESVLVSAHTSAGKTVVAEYAVAQSLRDKQRVIYTSPIKALSNQKYRELLAEFGD--- 267
Cdd:COG1204 16 KERGIEELYPPQAEALeAGLLEGKNLVVSAPTASGKTLIAELAILKALLNGGKALYIVPLRALASEKYREFKRDFEElgi 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 268 -VGLMTGDVTINP----DATCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDKERGVVWEETIILL---PDKSHFV 339
Cdd:COG1204 96 kVGVSTGDYDSDDewlgRYDILVATPEKLDSLLRNGPSWLRDVDLVVVDEAHLIDDESRGPTLEVLLARLrrlNPEAQIV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 340 FLSATIPNAMQFAEWItkihrqPCHVVYTDFRPTPLQHYLFPSGSdgihLVVDEKSNFREENFQRAMSALMEKQGddpaa 419
Cdd:COG1204 176 ALSATIGNAEEIAEWL------DAELVKSDWRPVPLNEGVLYDGV----LRFDDGSRRSKDPTLALALDLLEEGG----- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 420 matkgnakkgktgkggvkgpsdiykivkmimvknynPVIVFSFSKRECEALALQMSK-LDMNDQTErdlVTTIFNNAVNQ 498
Cdd:COG1204 241 ------------------------------------QVLVFVSSRRDAESLAKKLADeLKRRLTPE---EREELEELAEE 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 499 LSEKDRELPQIEHILPLLRRGIGIHHSGLLPILKEVIEILFQEGLLKVLFATETFSIGLNMPAKTVVFTNVRKFDGKtfr 578
Cdd:COG1204 282 LLEVSEETHTNEKLADCLEKGVAFHHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDTKRGGMV--- 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 579 WISGGEYIQMSGRAGRRGLDDRGIVIL------MIDEKMDPPVaksmlKGEADRLDSAFHLSYNMILNLLRV--EGISP- 649
Cdd:COG1204 359 PIPVLEFKQMAGRAGRPGYDPYGEAILvakssdEADELFERYI-----LGEPEPIRSKLANESALRTHLLALiaSGFANs 433
|
490 500 510
....*....|....*....|....*....|.
gi 3287946 650 --EFM--LERCFFQFQNSLEVpkLEAKLEES 676
Cdd:COG1204 434 reELLdfLENTFYAYQYDKGD--LEEVVDDA 462
|
|
| DSHCT |
pfam08148 |
DSHCT (NUC185) domain; This C terminal domain is found in DOB1/SK12/helY-like DEAD box ... |
942-1110 |
1.36e-68 |
|
DSHCT (NUC185) domain; This C terminal domain is found in DOB1/SK12/helY-like DEAD box helicases.
Pssm-ID: 462374 Cd Length: 154 Bit Score: 226.56 E-value: 1.36e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 942 DVIEVKGRVACEISSGDGLLLTELIFNGMFNDLTPEQCAALLSCLVFQEKSEvENQRMKEELAGPLKILQEMARRIAkVS 1021
Cdd:pfam08148 1 DVVTLKGRVACEIRSENELLLTELLFSGVFDDLDPEELAALLSAFVFEEKRR-EPYLPSPELAEALRLLEEIAHRIA-VS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 1022 KEskqelneeeyvnsFKPSLMEVVYAWAHGASFAQICKMTDVYEGSLIRMFRRLEELIRQMVDAAKVIGNTSLQQKMEDT 1101
Cdd:pfam08148 79 RF-------------LDFGLMEVVYAWARGASFAEICKLTDLDEGDIVRLIRRLDELLRQIANAAKIIGDPELREKAEEA 145
|
....*....
gi 3287946 1102 IACIHRDIV 1110
Cdd:pfam08148 146 IELIKRDIV 154
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
371-608 |
8.46e-64 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 212.80 E-value: 8.46e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 371 RPTPLQHYLFPSGSDGIHLVVDEKSNFreenfqramsalmekqgddpaamatkgnakkgktgkggvkgPSDIYKIVKMIM 450
Cdd:cd18795 1 RPVPLEEYVLGFNGLGIKLRVDVMNKF-----------------------------------------DSDIIVLLKIET 39
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 451 VKNYNPVIVFSFSKRECEALALQMSkldmndqterdlvttifnnavnqlsekdrelpqiehilpllrrGIGIHHSGLLPI 530
Cdd:cd18795 40 VSEGKPVLVFCSSRKECEKTAKDLA-------------------------------------------GIAFHHAGLTRE 76
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3287946 531 LKEVIEILFQEGLLKVLFATETFSIGLNMPAKTVVFTNVRKFDGKTFRWISGGEYIQMSGRAGRRGLDDRGIVILMID 608
Cdd:cd18795 77 DRELVEELFREGLIKVLVATSTLAAGVNLPARTVIIKGTQRYDGKGYRELSPLEYLQMIGRAGRPGFDTRGEAIIMTK 154
|
|
| KOW_Mtr4 |
cd13154 |
KOW_Mtr4 is an inserted domain in Mtr4 globular domain; Mtr4 is a conserved helicase with a ... |
721-852 |
9.82e-59 |
|
KOW_Mtr4 is an inserted domain in Mtr4 globular domain; Mtr4 is a conserved helicase with a core DExH region that cooperates with the eukaryotic nuclear exosome in RNA processing and degradation. KOW_Mtr4 motif might be involved in presenting RNA substrates to the helicase core. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW motif is located at the extended insertion of Mtr4 protein.
Pssm-ID: 240518 Cd Length: 129 Bit Score: 197.41 E-value: 9.82e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 721 FLQGGRLVRVKVGNEDFDWGVVVNVSKRPLPKGQSNEYLPQESYIVHTLVMVASDTGplrIRSGHLPEVHPPAAEDKGKF 800
Cdd:cd13154 1 FLQPGRLVKVKVGDDDFGWGVVVNFQKRPNKKNGSENSPPQESYVVDVLLNCSSGSS---INNGSPSGIRPPGPGEKGEM 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 3287946 801 EVVPFLLSSLDGIAHIRVFLPNDLKSQGQKLTVGKALSEVKRRFPEGITLLD 852
Cdd:cd13154 78 EVVPVLLSLIQAISSIRLYLPKDLRSADARQSVGKSLQEVKRRFPDGLPLLD 129
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
198-359 |
9.16e-58 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 197.10 E-value: 9.16e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 198 TLDPFQAVSIACI-ERQESVLVSAHTSAGKTVVAEYAVAQSLRD-KQRVIYTSPIKALSNQKYRELLAEFG----DVGLM 271
Cdd:cd17921 1 LLNPIQREALRALyLSGDSVLVSAPTSSGKTLIAELAILRALATsGGKAVYIAPTRALVNQKEADLRERFGplgkNVGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 272 TGDVTIN----PDATCLVMTTEILRSMLYRGSE-VMREVAWVIFDEIHYMRDKERGVVWEETIILLP---DKSHFVFLSA 343
Cdd:cd17921 81 TGDPSVNklllAEADILVATPEKLDLLLRNGGErLIQDVRLVVVDEAHLIGDGERGVVLELLLSRLLrinKNARFVGLSA 160
|
170
....*....|....*.
gi 3287946 344 TIPNAMQFAEWITKIH 359
Cdd:cd17921 161 TLPNAEDLAEWLGVED 176
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
197-708 |
2.30e-37 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 150.42 E-value: 2.30e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 197 FTLDPFQAVSIACIERQESVLVSAHTSAGKTVVAEYAVAQSLRDKQRVIYTSPIKALSNQKYREL--LAEFG-DVGLMTG 273
Cdd:PRK01172 21 FELYDHQRMAIEQLRKGENVIVSVPTAAGKTLIAYSAIYETFLAGLKSIYIVPLRSLAMEKYEELsrLRSLGmRVKISIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 274 DVTINPD----ATCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDKERGVVWEETI----ILLPDkSHFVFLSATI 345
Cdd:PRK01172 101 DYDDPPDfikrYDVVILTSEKADSLIHHDPYIINDVGLIVADEIHIIGDEDRGPTLETVLssarYVNPD-ARILALSATV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 346 PNAMQFAEWITkihrqpCHVVYTDFRPTPLQHYLFPsgSDGIHLVVDEKSNFreenfqramsalmekqgddpaamatkgn 425
Cdd:PRK01172 180 SNANELAQWLN------ASLIKSNFRPVPLKLGILY--RKRLILDGYERSQV---------------------------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 426 akkgktgkggvkgpsDIYKIVKMImVKNYNPVIVFSFSKRECEALALQMSKL--DMNDQTERDLVTTIFNNAVNQlsekd 503
Cdd:PRK01172 224 ---------------DINSLIKET-VNDGGQVLVFVSSRKNAEDYAEMLIQHfpEFNDFKVSSENNNVYDDSLNE----- 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 504 relpqiehilpLLRRGIGIHHSGLLPILKEVIEILFQEGLLKVLFATETFSIGLNMPAKTVVFTNVRKFDGKTFRWISGG 583
Cdd:PRK01172 283 -----------MLPHGVAFHHAGLSNEQRRFIEEMFRNRYIKVIVATPTLAAGVNLPARLVIVRDITRYGNGGIRYLSNM 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 584 EYIQMSGRAGRRGLDDRGIVILMIDEKMDPPVAKSMLKGEADRLDSAFHLSYNMILNLLRVEGI----SPEFML---ERC 656
Cdd:PRK01172 352 EIKQMIGRAGRPGYDQYGIGYIYAASPASYDAAKKYLSGEPEPVISYMGSQRKVRFNTLAAISMglasSMEDLIlfyNET 431
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 3287946 657 FFQFQNslEVPKLEAKLEESQQHYDSFTILDERPleEYHTlkTQLERYRTDV 708
Cdd:PRK01172 432 LMAIQN--GVDEIDYYIESSLKFLKENGFIKGDV--TLRA--TRLGKLTSDL 477
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
199-606 |
2.87e-36 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 147.80 E-value: 2.87e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 199 LDPFQAvsiACIER----QESVLVSAHTSAGKTVVAEYAVAQSLRDKQRVIYTSPIKALSNQKYREL--LAEFG-DVGLM 271
Cdd:PRK02362 24 LYPPQA---EAVEAglldGKNLLAAIPTASGKTLIAELAMLKAIARGGKALYIVPLRALASEKFEEFerFEELGvRVGIS 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 272 TGDvtinPDAT--------CLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDKERGVVWEETIILL----PDkSHFV 339
Cdd:PRK02362 101 TGD----YDSRdewlgdndIIVATSEKVDSLLRNGAPWLDDITCVVVDEVHLIDSANRGPTLEVTLAKLrrlnPD-LQVV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 340 FLSATIPNAMQFAEWITkihrqpCHVVYTDFRPTPLQhylfpsgsDGIHLvvDEKSNFREEnfQRAMSalmEKQGDDPAA 419
Cdd:PRK02362 176 ALSATIGNADELADWLD------AELVDSEWRPIDLR--------EGVFY--GGAIHFDDS--QREVE---VPSKDDTLN 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 420 MAtkgnakkgktgkggvkgpSDIykivkmimVKNYNPVIVFSFSKRECEALALQMSkldmndQTERDLVTTIFNNAVNQL 499
Cdd:PRK02362 235 LV------------------LDT--------LEEGGQCLVFVSSRRNAEGFAKRAA------SALKKTLTAAERAELAEL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 500 SEKDRELPQIEHILPL---LRRGIGIHHSGLLPILKEVIEILFQEGLLKVLFATETFSIGLNMPAKTVVFTNVRKFDGKT 576
Cdd:PRK02362 283 AEEIREVSDTETSKDLadcVAKGAAFHHAGLSREHRELVEDAFRDRLIKVISSTPTLAAGLNLPARRVIIRDYRRYDGGA 362
|
410 420 430
....*....|....*....|....*....|.
gi 3287946 577 -FRWISGGEYIQMSGRAGRRGLDDRGIVILM 606
Cdd:PRK02362 363 gMQPIPVLEYHQMAGRAGRPGLDPYGEAVLL 393
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
214-675 |
5.33e-36 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 146.89 E-value: 5.33e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 214 ESVLVSAHTSAGKTVVAEYAVAQS-LRDKQRVIYTSPIKALSNQKYRELlAEFGDVGLMTGDVTINPDAT--------CL 284
Cdd:PRK00254 40 KNLVLAIPTASGKTLVAEIVMVNKlLREGGKAVYLVPLKALAEEKYREF-KDWEKLGLRVAMTTGDYDSTdewlgkydII 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 285 VMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDKERGVVWEETIILLPDKSHFVFLSATIPNAMQFAEWITkihrqpCH 364
Cdd:PRK00254 119 IATAEKFDSLLRHGSSWIKDVKLVVADEIHLIGSYDRGATLEMILTHMLGRAQILGLSATVGNAEELAEWLN------AE 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 365 VVYTDFRPTPLQHYLFPSG----SDGihlvvdeksnfREENFqramsalmekqgddpaamatkgnakkgktgkggvkgPS 440
Cdd:PRK00254 193 LVVSDWRPVKLRKGVFYQGflfwEDG-----------KIERF------------------------------------PN 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 441 DIYKIVkMIMVKNYNPVIVFSFSKRECEALALQMSKLDMNDQTERDLvttifnNAVNQLSEKDRELPQIEHILPLLRRGI 520
Cdd:PRK00254 226 SWESLV-YDAVKKGKGALVFVNTRRSAEKEALELAKKIKRFLTKPEL------RALKELADSLEENPTNEKLKKALRGGV 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 521 GIHHSGLLPILKEVIEILFQEGLLKVLFATETFSIGLNMPAKTVVFTNVRKFDGKTFRWISGGEYIQMSGRAGRRGLDDR 600
Cdd:PRK00254 299 AFHHAGLGRTERVLIEDAFREGLIKVITATPTLSAGINLPAFRVIIRDTKRYSNFGWEDIPVLEIQQMMGRAGRPKYDEV 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 601 GIVILMIDEKMDPPVAKSMLKGEADRL------DSAFHlsyNMILNLLRVEGIS--PEFM--LERCFFQFQNSlEVPKLE 670
Cdd:PRK00254 379 GEAIIVATTEEPSKLMERYIFGKPEKLfsmlsnESAFR---SQVLALITNFGVSnfKELVnfLERTFYAHQRK-DLYSLE 454
|
....*
gi 3287946 671 AKLEE 675
Cdd:PRK00254 455 EKAKE 459
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
201-346 |
4.98e-30 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 116.96 E-value: 4.98e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 201 PFQAVSIACIERQESVLVSAHTSAGKTVVAEYAVAQSLRDKQ---RVIYTSPIKALSNQKYRELLAEFGDVGLM----TG 273
Cdd:pfam00270 2 PIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDngpQALVLAPTRELAEQIYEELKKLGKGLGLKvaslLG 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3287946 274 DVTINPDAT------CLVMTTEILRSMLYRgSEVMREVAWVIFDEIHYMRDKERGVVWEETIILLPDKSHFVFLSATIP 346
Cdd:pfam00270 82 GDSRKEQLEklkgpdILVGTPGRLLDLLQE-RKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLLSATLP 159
|
|
| DEXHc_DDX60 |
cd18025 |
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an ... |
210-360 |
8.62e-30 |
|
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an IFN-inducible cytoplasmic helicase that plays a role in RIG-I-mediated type I interferon (IFN) nuclease-mediated viral RNA degradation. DDX60 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350783 [Multi-domain] Cd Length: 192 Bit Score: 117.08 E-value: 8.62e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 210 IERQESVLVSAHTSAGKTVVAEYAVAQSLR--DKQRVIYTSPIKALSNQKYRELLAEFGD---------VGLMTGDVTIN 278
Cdd:cd18025 13 VDRRESALIVAPTSSGKTFISYYCMEKVLResDDGVVVYVAPTKALVNQVVAEVYARFSKkyppsgkslWGVFTRDYRHN 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 279 PDATCLVMTT--EILRSML---YRGSEVMReVAWVIFDEIHYMRDKERGVVWEETIILLPdkSHFVFLSATIPNAMQFAE 353
Cdd:cd18025 93 NPMNCQVLITvpECLEILLlspHNASWVPR-IKYVIFDEIHSIGQSEDGAVWEQLLLLIP--CPFLALSATIGNPQKFHE 169
|
....*..
gi 3287946 354 WITKIHR 360
Cdd:cd18025 170 WLQSVQR 176
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
196-378 |
4.43e-29 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 115.67 E-value: 4.43e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 196 PFTLDPFQAVSIACI-ERQESVLVSAHTSAGKTVVAEYAVAQSLR--DKQRVIYTSPIKALSNQKYRELLAEFGD----- 267
Cdd:smart00487 6 FEPLRPYQKEAIEALlSGLRDVILAAPTGSGKTLAALLPALEALKrgKGGRVLVLVPTRELAEQWAEELKKLGPSlglkv 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 268 VGLMTGDVT-------INPDATCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDKERGVVWEETIILLPDKSHFVF 340
Cdd:smart00487 86 VGLYGGDSKreqlrklESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPKNVQLLL 165
|
170 180 190
....*....|....*....|....*....|....*...
gi 3287946 341 LSATIPNAMQFAEWitKIHRQPCHVVYTDFRPTPLQHY 378
Cdd:smart00487 166 LSATPPEEIENLLE--LFLNDPVFIDVGFTPLEPIEQF 201
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
198-355 |
7.02e-28 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 111.27 E-value: 7.02e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 198 TLDPFQAVSI-ACIERQESVLVSAHTSAGKTVVAEYAVAQSLRDKQRVIYTSPIKALSNQKYREL--LAEFG-DVGLMTG 273
Cdd:cd18028 1 ELYPPQAEAVrAGLLKGENLLISIPTASGKTLIAEMAMVNTLLEGGKALYLVPLRALASEKYEEFkkLEEIGlKVGISTG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 274 DVTIN----PDATCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDKERGVVWEETII---LLPDKSHFVFLSATIP 346
Cdd:cd18028 81 DYDEDdewlGDYDIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIHLISDEERGPTLESIVArlrRLNPNTQIIGLSATIG 160
|
....*....
gi 3287946 347 NAMQFAEWI 355
Cdd:cd18028 161 NPDELAEWL 169
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
208-372 |
5.91e-21 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 92.42 E-value: 5.91e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 208 ACIERQESVLVSAHTSAGKTVVAEYAVAQSLRD-------KQRVIYTSPIKALSNQKYRELLAEFGDVGL----MTGDVT 276
Cdd:cd18023 12 DLLYSDKNFVVSAPTGSGKTVLFELAILRLLKErnplpwgNRKVVYIAPIKALCSEKYDDWKEKFGPLGLscaeLTGDTE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 277 IN-----PDATCLVMTTEILRSMLYRGSE---VMREVAWVIFDEIHYMRDkERGVVWE-------------ETIILLPDK 335
Cdd:cd18023 92 MDdtfeiQDADIILTTPEKWDSMTRRWRDngnLVQLVALVLIDEVHIIKE-NRGATLEvvvsrmktlssssELRGSTVRP 170
|
170 180 190
....*....|....*....|....*....|....*..
gi 3287946 336 SHFVFLSATIPNAMQFAEWItKIHRQPCHVVYTDFRP 372
Cdd:cd18023 171 MRFVAVSATIPNIEDLAEWL-GDNPAGCFSFGESFRP 206
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
198-625 |
7.03e-19 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 92.65 E-value: 7.03e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 198 TLDPFQ--AVSIACIERQESVLVSAhTSAGKTVVAEYA-VAQSLRDKQRVIYTSPIKALSNQKYRELLAEFG---DVGLM 271
Cdd:COG1202 209 ELLPVQslAVENGLLEGKDQLVVSA-TATGKTLIGELAgIKNALEGKGKMLFLVPLVALANQKYEDFKDRYGdglDVSIR 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 272 TGDVTIN-------PDATCLVMTTEILRSMLyRGSEVMREVAWVIFDEIHYMRDKERGVVWEETIILL----PDkSHFVF 340
Cdd:COG1202 288 VGASRIRddgtrfdPNADIIVGTYEGIDHAL-RTGRDLGDIGTVVIDEVHMLEDPERGHRLDGLIARLkyycPG-AQWIY 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 341 LSATIPNAMQFAEwitkihRQPCHVVYTDFRPTPLQHYLfpsgsdgihLVVDEKSNFREENfqramsalmekqgddpaam 420
Cdd:COG1202 366 LSATVGNPEELAK------KLGAKLVEYEERPVPLERHL---------TFADGREKIRIIN------------------- 411
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 421 atkgnakkgktgkggvkgpsdiyKIVKmimvKNYNPV---------IVFSFSKRECEALAlqmskldmndqterdlvtti 491
Cdd:COG1202 412 -----------------------KLVK----REFDTKsskgyrgqtIIFTNSRRRCHEIA-------------------- 444
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 492 fnnavnqlsekdrelpqiehilpllrRGIGI----HHSGLLPILKEVIEILFQEGLLKVLFATETFSIGLNMPAKTVVFT 567
Cdd:COG1202 445 --------------------------RALGYkaapYHAGLDYGERKKVERRFADQELAAVVTTAALAAGVDFPASQVIFD 498
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3287946 568 NVRKfdGKtfRWISGGEYIQMSGRAGRRGLDDRGIVILMID---------EKMDPPVAKSMLKGEAD 625
Cdd:COG1202 499 SLAM--GI--EWLSVQEFHQMLGRAGRPDYHDRGKVYLLVEpgksyhrsmEMTEDEVAFKLLKGEME 561
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
214-355 |
8.02e-18 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 81.86 E-value: 8.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 214 ESVLVSAHTSAGKTVVAEYAVAQSLRDKQ----RVIYTSPIKALSNQKYR---ELLAEFG---DVGLMTGDVT------- 276
Cdd:cd17922 2 RNVLIAAPTGSGKTEAAFLPALSSLADEPekgvQVLYISPLKALINDQERrleEPLDEIDleiPVAVRHGDTSqsekakq 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 277 -INPDaTCLVMTTEILRSMLY--RGSEVMREVAWVIFDEIHYMRDKERGVVWEETIILLPDKSHFVF----LSATIPNAM 349
Cdd:cd17922 82 lKNPP-GILITTPESLELLLVnkKLRELFAGLRYVVVDEIHALLGSKRGVQLELLLERLRKLTGRPLrrigLSATLGNLE 160
|
....*.
gi 3287946 350 QFAEWI 355
Cdd:cd17922 161 EAAAFL 166
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
508-596 |
4.14e-14 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 68.39 E-value: 4.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 508 QIEHILPLLRRGIGIHHSGLLPILKEVIEILFQEGLLKVLFATETFSIGLNMP-AKTVVFTNVrkfdgktfrWISGGEYI 586
Cdd:smart00490 2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVIIYDL---------PWSPASYI 72
|
90
....*....|
gi 3287946 587 QMSGRAGRRG 596
Cdd:smart00490 73 QRIGRAGRAG 82
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
214-344 |
1.34e-13 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 69.35 E-value: 1.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 214 ESVLVSAHTSAGKTVVAEYAVAQSLRDKQ-RVIYTSPIKALSNQKYRELLAEFG---DVGLMTGDVT-------INPDAT 282
Cdd:cd00046 2 ENVLITAPTGSGKTLAALLAALLLLLKKGkKVLVLVPTKALALQTAERLRELFGpgiRVAVLVGGSSaeereknKLGDAD 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3287946 283 CLVMTTE-ILRSMLYRGSEVMREVAWVIFDEIHYMRDKERGVVWEETII--LLPDKSHFVFLSAT 344
Cdd:cd00046 82 IIIATPDmLLNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVrkAGLKNAQVILLSAT 146
|
|
| DEXHc_ASCC3_2 |
cd18022 |
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
214-355 |
1.17e-12 |
|
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350780 [Multi-domain] Cd Length: 189 Bit Score: 67.78 E-value: 1.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 214 ESVLVSAHTSAGKTVVAEYAVAQSLRD--KQRVIYTSPIKALSNQKYRELLAEFGDV-GL----MTGDVTINP----DAT 282
Cdd:cd18022 18 NNVLLGAPTGSGKTIAAELAMFRAFNKypGSKVVYIAPLKALVRERVDDWKKRFEEKlGKkvveLTGDVTPDMkalaDAD 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 283 CLVMTTE----ILRSMLYRgsEVMREVAWVIFDEIHyMRDKERGVVWEetIILLPDK---SH------FVFLSATIPNAM 349
Cdd:cd18022 98 IIITTPEkwdgISRSWQTR--EYVQQVSLIIIDEIH-LLGSDRGPVLE--VIVSRMNyisSQtekpvrLVGLSTALANAG 172
|
....*.
gi 3287946 350 QFAEWI 355
Cdd:cd18022 173 DLANWL 178
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
162-605 |
6.53e-12 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 69.86 E-value: 6.53e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 162 ELRHQVRHQVSIPPnydyvpiskhkspiPPARTYPF--TLDP----------------FQAVSIACIERQESVLVSAHTS 223
Cdd:COG1205 16 RYGDQIVHVRTIPA--------------REARYAPWpdWLPPelraalkkrgierlysHQAEAIEAARAGKNVVIATPTA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 224 AGKTVVAEYAVAQSLRDKQ--RVIYTSPIKALSN---QKYRELLAEFG---DVGLMTGD---------------VTINPD 280
Cdd:COG1205 82 SGKSLAYLLPVLEALLEDPgaTALYLYPTKALARdqlRRLRELAEALGlgvRVATYDGDtppeerrwirehpdiVLTNPD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 281 atclvmtteilrsMLYRG--------SEVMREVAWVIFDEIH-YmrdkeRGV----V-WeetII--------LLPDKSHF 338
Cdd:COG1205 162 -------------MLHYGllphhtrwARFFRNLRYVVIDEAHtY-----RGVfgshVaN---VLrrlrricrHYGSDPQF 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 339 VFLSATIPNAMQFAEWITKihrQPCHVVYTDFRPTPLQHYLF---PSGSDGIhlvvdeksnfreenfqRAmSALMEkqgd 415
Cdd:COG1205 221 ILASATIGNPAEHAERLTG---RPVTVVDEDGSPRGERTFVLwnpPLVDDGI----------------RR-SALAE---- 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 416 dpAAmatkgnakkgktgkggvkgpsdiyKIVKMIMVKNYNpVIVFSFSKRECEALALQmskldmndqterdlvttifnnA 495
Cdd:COG1205 277 --AA------------------------RLLADLVREGLR-TLVFTRSRRGAELLARY---------------------A 308
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 496 VNQLSEkdrelpqiehilPLLRRGIGIHHSGLLPILKEVIEILFQEGLLKVLFATETFSIGLNMP---AktVVftnvrkf 572
Cdd:COG1205 309 RRALRE------------PDLADRVAAYRAGYLPEERREIERGLRSGELLGVVSTNALELGIDIGgldA--VV------- 367
|
490 500 510
....*....|....*....|....*....|....*...
gi 3287946 573 dgktfrwISG--GE---YIQMSGRAGRRGldDRGIVIL 605
Cdd:COG1205 368 -------LAGypGTrasFWQQAGRAGRRG--QDSLVVL 396
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
201-389 |
1.25e-11 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 68.98 E-value: 1.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 201 PFQAVSIACIERQESVLVSAHTSAGKT------VVAEYA---VAQSLRDKQRVIYTSPIKALSNQKYREL---LAEFGD- 267
Cdd:COG1201 27 PPQREAWPAIAAGESTLLIAPTGSGKTlaaflpALDELArrpRPGELPDGLRVLYISPLKALANDIERNLrapLEEIGEa 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 268 ---------VGLMTGDVTIN---------PDatCLVMTTEILRSMLY--RGSEVMREVAWVIFDEIHYMRDKERGVVWEE 327
Cdd:COG1201 107 aglplpeirVGVRTGDTPASerqrqrrrpPH--ILITTPESLALLLTspDARELLRGVRTVIVDEIHALAGSKRGVHLAL 184
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3287946 328 TI----ILLPDKSHFVFLSATIPNAMQFAEWIT-KIHRQPCHVVYTDFR----------PTPLQHYLFPSGSDGIHL 389
Cdd:COG1201 185 SLerlrALAPRPLQRIGLSATVGPLEEVARFLVgYEDPRPVTIVDAGAGkkpdlevlvpVEDLIERFPWAGHLWPHL 261
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
214-355 |
4.09e-10 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 60.35 E-value: 4.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 214 ESVLVSAHTSAGKTVVAEYAVAQSLR--DKQRVIYTSPIKALSNQKYRELLAEFGDVG-----LMTGDVTINP---DATC 283
Cdd:cd18021 20 DNVFVGAPTGSGKTVCAELALLRHWRqnPKGRAVYIAPMQELVDARYKDWRAKFGPLLgkkvvKLTGETSTDLkllAKSD 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 284 LVMTT----EILrSMLYRGSEVMREVAWVIFDEIHyMRDKERGVVWEetIIL---------LPDKSHFVFLSATIPNAMQ 350
Cdd:cd18021 100 VILATpeqwDVL-SRRWKQRKNVQSVELFIADELH-LIGGENGPVYE--VVVsrmryissqLEKPIRIVGLSSSLANARD 175
|
....*
gi 3287946 351 FAEWI 355
Cdd:cd18021 176 VGEWL 180
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
203-353 |
7.13e-10 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 59.52 E-value: 7.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 203 QAVSIACIERQESVLVSAHTSAGKTVVAEYAVAQSL-RDKQ-RVIYTSPIKALSN---QKYRELLAEFG---DVGLMTGD 274
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALlRDPGsRALYLYPTKALAQdqlRSLRELLEQLGlgiRVATYDGD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 275 --------VTINPdATCLVMTTEILRSMLYRGSE----VMREVAWVIFDEIHYMrdkeRGVVWEETIILL--------PD 334
Cdd:cd17923 85 tpreerraIIRNP-PRILLTNPDMLHYALLPHHDrwarFLRNLRYVVLDEAHTY----RGVFGSHVALLLrrlrrlcrRY 159
|
170 180
....*....|....*....|.
gi 3287946 335 KSHFVFL--SATIPNAMQFAE 353
Cdd:cd17923 160 GADPQFIltSATIGNPAEHAR 180
|
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
203-372 |
9.23e-10 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 59.54 E-value: 9.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 203 QAVSIACIERQESVLVSAHTSAGKTVVAE-YAVAQSLRDKQRVIYTSPIKALSNQKYRELLAEFGDVGL----MTGDVTI 277
Cdd:cd18026 23 ECLSLPGLLEGRNLVYSLPTSGGKTLVAEiLMLKRLLERRKKALFVLPYVSIVQEKVDALSPLFEELGFrvegYAGNKGR 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 278 NP-----DATCLVMTTEILRSMLYRGSEVMR--EVAWVIFDEIHYMRDKERGVVWEETIILL----PDKSHFVFLSATIP 346
Cdd:cd18026 103 SPpkrrkSLSVAVCTIEKANSLVNSLIEEGRldELGLVVVDELHMLGDGHRGALLELLLTKLlyaaQKNIQIVGMSATLP 182
|
170 180
....*....|....*....|....*.
gi 3287946 347 NAMQFAEWITkihrqpCHVVYTDFRP 372
Cdd:cd18026 183 NLEELASWLR------AELYTTNFRP 202
|
|
| SF2_C_suv3 |
cd18805 |
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ... |
545-606 |
9.88e-10 |
|
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350192 [Multi-domain] Cd Length: 135 Bit Score: 57.57 E-value: 9.88e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3287946 545 KVLFATETFSIGLNMPAKTVVFTNVRKFDGKTFRWISGGEYIQMSGRAGRRGLD-DRGIVILM 606
Cdd:cd18805 72 DVLVASDAIGMGLNLNIRRVIFSSLSKFDGNEMRPLSPSEVKQIAGRAGRFGSHfPEGEVTTL 134
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
193-323 |
1.72e-08 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 58.74 E-value: 1.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 193 RTY-PFTldPFQAVSIACIERQESVLVSAHTSAGKTVVA---------EYAVAQSLRDKQRVIYTSPIKALSNQKYR--- 259
Cdd:PRK13767 28 EKFgTFT--PPQRYAIPLIHEGKNVLISSPTGSGKTLAAflaiidelfRLGREGELEDKVYCLYVSPLRALNNDIHRnle 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 260 -------ELLAEFGD------VGLMTGDVT-------------InpdatcLVMTTEILRSMLY--RGSEVMREVAWVIFD 311
Cdd:PRK13767 106 eplteirEIAKERGEelpeirVAIRTGDTSsyekqkmlkkpphI------LITTPESLAILLNspKFREKLRTVKWVIVD 179
|
170
....*....|..
gi 3287946 312 EIHYMRDKERGV 323
Cdd:PRK13767 180 EIHSLAENKRGV 191
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
218-355 |
4.25e-08 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 57.63 E-value: 4.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 218 VSAHTSAGKTVVA-EYAVAQSLRDK------------QRVIYTSPIKALSNQKYREL---LAEFGD-------------V 268
Cdd:PRK09751 1 VIAPTGSGKTLAAfLYALDRLFREGgedtreahkrktSRILYISPIKALGTDVQRNLqipLKGIADerrrrgetevnlrV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 269 GLMTGDVTIN---------PDatCLVMTTEILRSMLY-RGSEVMREVAWVIFDEIHYMRDKERG----VVWEETIILLPD 334
Cdd:PRK09751 81 GIRTGDTPAQerskltrnpPD--ILITTPESLYLMLTsRARETLRGVETVIIDEVHAVAGSKRGahlaLSLERLDALLHT 158
|
170 180
....*....|....*....|.
gi 3287946 335 KSHFVFLSATIPNAMQFAEWI 355
Cdd:PRK09751 159 SAQRIGLSATVRSASDVAAFL 179
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
162-707 |
1.05e-07 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 56.19 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 162 ELRHQVRHQVSIPPNYDYVPISKHKSPIPPARTYPFTLDPFQ-----AVSIACIERQESVLVSAHTSAGKTVVAEYAVAQ 236
Cdd:COG1061 44 EGTREDGRRLPEEDTERELAEAEALEAGDEASGTSFELRPYQqealeALLAALERGGGRGLVVAPTGTGKTVLALALAAE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 237 sLRDKQRVIYTSPIKALSNQKYRELLAEFGDVGlmTGDVTINPDATCLVMTTEILRSMLYRgSEVMREVAWVIFDEIHYM 316
Cdd:COG1061 124 -LLRGKRVLVLVPRRELLEQWAEELRRFLGDPL--AGGGKKDSDAPITVATYQSLARRAHL-DELGDRFGLVIIDEAHHA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 317 RDKergvVWEETIILLPDKsHFVFLSAT--------IPNAMQfaewitkihrqpCHVVYtDFRPTPL--QHYLFPsgsdg 386
Cdd:COG1061 200 GAP----SYRRILEAFPAA-YRLGLTATpfrsdgreILLFLF------------DGIVY-EYSLKEAieDGYLAP----- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 387 IHLVVDEKSNFREENFQRAMSALMEKQGDDPAAMAtkgnakkgktgkggvkgpsdiYKIVKMIMVKNYN--PVIVFSFSK 464
Cdd:COG1061 257 PEYYGIRVDLTDERAEYDALSERLREALAADAERK---------------------DKILRELLREHPDdrKTLVFCSSV 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 465 RECEALALQMSKLDMNdqterdlVTTIfnnaVNQLSEKDRElpqiehilpllrrgigihhsgllpilkEVIEiLFQEGLL 544
Cdd:COG1061 316 DHAEALAELLNEAGIR-------AAVV----TGDTPKKERE---------------------------EILE-AFRDGEL 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 545 KVLFATETFSIGLNMP-AKTVVFtnVRKFDgktfrwiSGGEYIQMSGRAGRRGLD-DRGIVILMIDEKMDppvaksMLKG 622
Cdd:COG1061 357 RILVTVDVLNEGVDVPrLDVAIL--LRPTG-------SPREFIQRLGRGLRPAPGkEDALVYDFVGNDVP------VLEE 421
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 623 EADRLDSAFHLSYNMILNLLRVEGISPEFMLERCFFQFQNSLEVPKLEAKLEESQQHYDSFTILDERPLEEYHTLKTQLE 702
Cdd:COG1061 422 LAKDLRDLAGYRVEFLDEEESEELALLIAVKPALEVKGELEEELLEELELLEDALLLVLAELLLLELLALALELLELAKA 501
|
....*
gi 3287946 703 RYRTD 707
Cdd:COG1061 502 EGKAE 506
|
|
| DEXHc_Brr2_1 |
cd18019 |
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD ... |
198-347 |
5.38e-07 |
|
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350777 [Multi-domain] Cd Length: 214 Bit Score: 51.60 E-value: 5.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 198 TLDPFQA-VSIACIERQESVLVSAHTSAGKTVVAEYAVAQSLR-----------DKQRVIYTSPIKALSNQKYREL---L 262
Cdd:cd18019 17 SLNRIQSkLFPAAFETDENLLLCAPTGAGKTNVALLTILREIGkhrnpdgtinlDAFKIVYIAPMKALVQEMVGNFskrL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 263 AEFG-DVGLMTGDVTINP---DATCLVMTTEILRSMLYRGS---EVMREVAWVIFDEIHYMRDkERGVVWE-------ET 328
Cdd:cd18019 97 APYGiTVAELTGDQQLTKeqiSETQIIVTTPEKWDIITRKSgdrTYTQLVRLIIIDEIHLLHD-DRGPVLEsivartiRQ 175
|
170
....*....|....*....
gi 3287946 329 IILLPDKSHFVFLSATIPN 347
Cdd:cd18019 176 IEQTQEYVRLVGLSATLPN 194
|
|
| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
214-361 |
5.87e-07 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 51.28 E-value: 5.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 214 ESVLVSAHTSAGKTVVAEYAVAQSL-----------RDKQRVIYTSPIKALSNQ---KYRELLAEFG-DVGLMTGDVTIN 278
Cdd:cd18020 18 ENMLICAPTGAGKTNIAMLTILHEIrqhvnqggvikKDDFKIVYIAPMKALAAEmveKFSKRLAPLGiKVKELTGDMQLT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 279 PD---ATCLVMTTEILRSMLYRGS----EVMREVAWVIFDEIHYMRDkERGVVWE-------------ETIILLpdkshf 338
Cdd:cd18020 98 KKeiaETQIIVTTPEKWDVVTRKSsgdvALSQLVRLLIIDEVHLLHD-DRGPVIEslvartlrqvestQSMIRI------ 170
|
170 180
....*....|....*....|...
gi 3287946 339 VFLSATIPNAMQFAEWItKIHRQ 361
Cdd:cd18020 171 VGLSATLPNYLDVADFL-RVNPY 192
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
196-352 |
8.40e-07 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 50.49 E-value: 8.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 196 PFTLDPFQAVSIACIE---RQE---SVLVSAHTSAGKTVVAEYAVAQSLRDKQRVIYTSPIKALSNQKYRELLAEFGD-- 267
Cdd:cd17918 13 PFSLTKDQAQAIKDIEkdlHSPepmDRLLSGDVGSGKTLVALGAALLAYKNGKQVAILVPTEILAHQHYEEARKFLPFin 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 268 VGLMTGDVT--INPDATCLVMTTEILRSmlyrgSEVMREVAWVIFDEIHYMrdkerGVVWEETIILLpDKSHFVFLSAT- 344
Cdd:cd17918 93 VELVTGGTKaqILSGISLLVGTHALLHL-----DVKFKNLDLVIVDEQHRF-----GVAQREALYNL-GATHFLEATATp 161
|
....*...
gi 3287946 345 IPNAMQFA 352
Cdd:cd17918 162 IPRTLALA 169
|
|
| DEXQc_Suv3 |
cd17913 |
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA ... |
222-325 |
8.50e-07 |
|
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA unwinding enzyme belonging to the class of DexH-box helicases. It localizes predominantly in the mitochondria, where it forms an RNA-degrading complex called mitochondrial degradosome (mtEXO) with exonuclease PNP (polynucleotide phosphorylase), that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Suv3 plays a role in the RNA surveillance system in mitochondria; it regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. It also confers salinity and drought stress tolerance by maintaining both photosynthesis and antioxidant machinery, probably via an increase in plant hormone levels such as gibberellic acid (GA3), the cytokinin zeatin (Z), and indole-3-acetic acid (IAA). Suv3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350671 [Multi-domain] Cd Length: 142 Bit Score: 49.48 E-value: 8.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 222 TSAGKTvvaeYAVAQSLRDKQRVIYTSPIKALSNQKYRELLAEFGDVGLMTGD-VTINPDATCLVMTTEilrsMLYRGSE 300
Cdd:cd17913 10 TNSGKT----YHALQRLKSAKSGVYCGPLRLLAWEVYERLNAEGVPCDLVTGQeRREVEGATHVSCTVE----MASISEP 81
|
90 100
....*....|....*....|....*
gi 3287946 301 VmrEVAwVIfDEIHYMRDKERGVVW 325
Cdd:cd17913 82 Y--DVA-VI-DEIQMIGDPQRGWAW 102
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
508-596 |
2.04e-06 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 47.59 E-value: 2.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 508 QIEHILPLLRRGIGIHHSGLLPILKEVIEILFQEGLLKVLFATETFSIGLNMP-AKTVVFTNVrkfdgktfrWISGGEYI 586
Cdd:pfam00271 29 EAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPdVDLVINYDL---------PWNPASYI 99
|
90
....*....|
gi 3287946 587 QMSGRAGRRG 596
Cdd:pfam00271 100 QRIGRAGRAG 109
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
208-345 |
2.06e-06 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 49.25 E-value: 2.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 208 ACIERQESVLVSAHTSAGKTVVAEYAVAQSLRDK-QRVIYTSP----IKALSNQKYRELLAEFGD-VGL-MTGDVTINPD 280
Cdd:cd17990 12 AALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAgGKIIVLEPrrvaARAAARRLATLLGEAPGEtVGYrVRGESRVGRR 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3287946 281 ATCLVMTTEILRSMLYRGSEvMREVAWVIFDEIHymrdkERGV--------VWEETIILLPDKShFVFLSATI 345
Cdd:cd17990 92 TRVEVVTEGVLLRRLQRDPE-LSGVGAVILDEFH-----ERSLdadlalalLLEVQQLLRDDLR-LLAMSATL 157
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
217-344 |
9.49e-06 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 46.53 E-value: 9.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 217 LVSAHTSAGKTVVAeyAVAQSLRDKQRVIYTSPIKALSNQKYRELLAEFGD--VGLMTGDVTINPDATCLVMTT-EILRS 293
Cdd:cd17926 22 ILVLPTGSGKTLTA--LALIAYLKELRTLIVVPTDALLDQWKERFEDFLGDssIGLIGGGKKKDFDDANVVVATyQSLSN 99
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 3287946 294 MLYRGSEVMREVAWVIFDEIHYMRDKErgvvWEEtiILLPDKSHFVF-LSAT 344
Cdd:cd17926 100 LAEEEKDLFDQFGLLIVDEAHHLPAKT----FSE--ILKELNAKYRLgLTAT 145
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
532-605 |
4.74e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 39.99 E-value: 4.74e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3287946 532 KEVIEILFQEglLKVLFATETFSIGLNMP-AKTVVFTNvrkfdgktfRWISGGEYIQMSGRAGrRGLDDRGIVIL 605
Cdd:cd18785 13 IEHAEEIASS--LEILVATNVLGEGIDVPsLDTVIFFD---------PPSSAASYIQRVGRAG-RGGKDEGEVIL 75
|
|
| DEXHc_cas3 |
cd17930 |
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase ... |
216-349 |
2.44e-03 |
|
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350688 [Multi-domain] Cd Length: 186 Bit Score: 40.35 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 216 VLVSAHTSAGKTVVAeYAVAQSLRDKQ---RVIYTSPIKALSNQ---KYRELLAEFGD---VGLMTGDVTINPDATC--- 283
Cdd:cd17930 4 VILEAPTGSGKTEAA-LLWALKLAARGgkrRIIYALPTRATINQmyeRIREILGRLDDedkVLLLHSKAALELLESDeep 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 284 ---------------------LVMTT--EILRSML-YRGSEVM-----REVawVIFDEIHyMRDKERGVVWEETIILLPD 334
Cdd:cd17930 83 dddpveavdwalllkrswlapIVVTTidQLLESLLkYKHFERRlhglaNSV--VVLDEVQ-AYDPEYMALLLKALLELLG 159
|
170
....*....|....*..
gi 3287946 335 K--SHFVFLSATIPNAM 349
Cdd:cd17930 160 ElgGPVVLMTATLPALL 176
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
216-353 |
5.31e-03 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 40.49 E-value: 5.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 216 VLVSAHTSAGKT----VVAEYAVAQSLRDkqRVIYTSPIKALSNQKYRELLAEFGDVGL-----MTGDVTINPD----AT 282
Cdd:cd09639 2 LVIEAPTGYGKTeaalLWALHSLKSQKAD--RVIIALPTRATINAMYRRAKEAFGETGLyhssiLSSRIKEMGDseefEH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3287946 283 CLVMTTEILRSMLYRG----------SEVMREV------------AWVIFDEIHYMRDKERGVVWEETIILLPDKSHFVF 340
Cdd:cd09639 80 LFPLYIHSNDTLFLDPitvctidqvlKSVFGEFghyeftlasianSLLIFDEVHFYDEYTLALILAVLEVLKDNDVPILL 159
|
170
....*....|....
gi 3287946 341 LSATIPN-AMQFAE 353
Cdd:cd09639 160 MSATLPKfLKEYAE 173
|
|
| |
