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Conserved domains on  [gi|81637589|sp|O34692|]
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RecName: Full=Uncharacterized HTH-type transcriptional regulator YvnA

Protein Classification

MarR family transcriptional regulator( domain architecture ID 12204203)

MarR family transcriptional regulator is a winged helix-turn-helix domain-containing protein, named for an Escherichia coli regulator of an operon that encodes a drug efflux pump

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  10498949

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
40-143 1.18e-26

helix_turn_helix multiple antibiotic resistance protein;


:

Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 96.12  E-value: 1.18e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81637589     40 HDHLKKDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNKKEIFYTLTDSGRKlaaL 119
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRE---L 77

                           90       100
                   ....*....|....*....|....
gi 81637589    120 HEQLHEKAKEQYKQLFNEFSIDDL 143
Cdd:smart00347  78 IEQLLEARSETLAELLAGLTAEEQ 101
 
Name Accession Description Interval E-value
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
40-143 1.18e-26

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 96.12  E-value: 1.18e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81637589     40 HDHLKKDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNKKEIFYTLTDSGRKlaaL 119
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRE---L 77

                           90       100
                   ....*....|....*....|....
gi 81637589    120 HEQLHEKAKEQYKQLFNEFSIDDL 143
Cdd:smart00347  78 IEQLLEARSETLAELLAGLTAEEQ 101
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
48-151 1.66e-14

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 66.15  E-value: 1.66e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81637589  48 TLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNKKEIFYTLTDSGRklaALHEQLHEKA 127
Cdd:COG1846  37 TPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGR---ALLEEARPAL 113

                        90       100
                ....*....|....*....|....
gi 81637589 128 KEQYKQLFNEFSIDDLKTVTAFFN 151
Cdd:COG1846 114 EALLAELLAGLSEEELEALLRLLR 137
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 47-105 3.63e-14

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 62.95  E-value: 3.63e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 81637589    47 WTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNKKEI 105
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
pheS PRK04172
phenylalanine--tRNA ligase subunit alpha;
69-144 6.68e-03

phenylalanine--tRNA ligase subunit alpha;


Pssm-ID: 235239 [Multi-domain]  Cd Length: 489  Bit Score: 35.96  E-value: 6.68e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81637589   69 LASRLHISKAAVSKAVHALLKHNIITVTKKpgnkKEIFYTLTDSGRKLAA--LHE-QLHEKAKEQykqlfNEFSIDDLK 144
Cdd:PRK04172  26 LAEKLGLPPEAVMRAAEWLEEKGLVKVEER----VEEVYVLTEEGKKYAEegLPErRLLNALKDG-----GEVSLDELK 95
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 69-125 9.93e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 33.43  E-value: 9.93e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 81637589  69 LASRLHISKAAVSKAVHALLKHNIITVTKKPgnkKEIFYTLTDsGRKLAALHEQLHE 125
Cdd:cd00090  26 LAERLGLSQSTVSRHLKKLEEAGLVESRREG---RRVYYSLTD-AERLLALLESLLE 78
 
Name Accession Description Interval E-value
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
40-143 1.18e-26

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 96.12  E-value: 1.18e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81637589     40 HDHLKKDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNKKEIFYTLTDSGRKlaaL 119
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRE---L 77

                           90       100
                   ....*....|....*....|....
gi 81637589    120 HEQLHEKAKEQYKQLFNEFSIDDL 143
Cdd:smart00347  78 IEQLLEARSETLAELLAGLTAEEQ 101
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
48-151 1.66e-14

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 66.15  E-value: 1.66e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81637589  48 TLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNKKEIFYTLTDSGRklaALHEQLHEKA 127
Cdd:COG1846  37 TPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGR---ALLEEARPAL 113

                        90       100
                ....*....|....*....|....
gi 81637589 128 KEQYKQLFNEFSIDDLKTVTAFFN 151
Cdd:COG1846 114 EALLAELLAGLSEEELEALLRLLR 137
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 47-105 3.63e-14

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 62.95  E-value: 3.63e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 81637589    47 WTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNKKEI 105
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
69-137 2.41e-06

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 44.92  E-value: 2.41e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81637589  69 LASRLHISKAAVSKAVHALLKHNIITVTKKPGNKKEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNE 137
Cdd:COG1510  48 LAEELGVSKSSVSTALRELEDWGLVRRVRKPGDRKDYFRAEKDVWELFRRVFRERLRREIDPTLELLRE 116
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
64-118 2.66e-05

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 41.34  E-value: 2.66e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 81637589  64 VNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGnkkeifYTLTDSGRKLAA 118
Cdd:COG1321  25 VRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGG------ITLTEEGRELAL 73
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
69-125 5.89e-04

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 37.18  E-value: 5.89e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 81637589  69 LASRLHISKAAVSKAVHALLKHNIITVTKKpgnKKEIFYTLTDSGrkLAALHEQLHE 125
Cdd:COG0640  39 LAEALGLSQSTVSHHLKVLREAGLVTSRRE---GRWVYYRLADEA--LAELLEWLLE 90
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 48-104 5.95e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 36.41  E-value: 5.95e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 81637589    48 TLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNKKE 104
Cdd:pfam12802   4 TPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 69-117 2.01e-03

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 35.66  E-value: 2.01e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 81637589     69 LASRLHISKAAVSKAVHALLKHNIITVTKKPGnkkeifYTLTDSGRKLA 117
Cdd:smart00529   4 IAERLNVSPPTVTEMLKKLEKMGLVEYEPYRG------ITLTEKGRRLA 46
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
69-124 4.65e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.11  E-value: 4.65e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 81637589     69 LASRLHISKAAVSKAVHALLKHNIITVTKKPgnkKEIFYTLTDSgrKLAALHEQLH 124
Cdd:smart00418  16 LAEILGLSQSTVSHHLKKLREAGLVESRREG---KRVYYSLTDE--KVADLLEELL 66
pheS PRK04172
phenylalanine--tRNA ligase subunit alpha;
69-144 6.68e-03

phenylalanine--tRNA ligase subunit alpha;


Pssm-ID: 235239 [Multi-domain]  Cd Length: 489  Bit Score: 35.96  E-value: 6.68e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81637589   69 LASRLHISKAAVSKAVHALLKHNIITVTKKpgnkKEIFYTLTDSGRKLAA--LHE-QLHEKAKEQykqlfNEFSIDDLK 144
Cdd:PRK04172  26 LAEKLGLPPEAVMRAAEWLEEKGLVKVEER----VEEVYVLTEEGKKYAEegLPErRLLNALKDG-----GEVSLDELK 95
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 69-125 9.93e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 33.43  E-value: 9.93e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 81637589  69 LASRLHISKAAVSKAVHALLKHNIITVTKKPgnkKEIFYTLTDsGRKLAALHEQLHE 125
Cdd:cd00090  26 LAERLGLSQSTVSRHLKKLEEAGLVESRREG---RRVYYSLTD-AERLLALLESLLE 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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