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Conserved domains on  [gi|342187063|sp|O35235|]
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RecName: Full=Tumor necrosis factor ligand superfamily member 11; AltName: Full=Osteoclast differentiation factor; Short=ODF; AltName: Full=Osteoprotegerin ligand; Short=OPGL; AltName: Full=Receptor activator of nuclear factor kappa-B ligand; Short=RANKL; AltName: Full=TNF-related activation-induced cytokine; Short=TRANCE; AltName: CD_antigen=CD254; Contains: RecName: Full=Tumor necrosis factor ligand superfamily member 11, membrane form; Contains: RecName: Full=Tumor necrosis factor ligand superfamily member 11, soluble form

Protein Classification

TNF domain-containing protein( domain architecture ID 10446394)

TNF domain-containing protein similar to Homo sapiens tumor necrosis factor, which acts as cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TNF pfam00229
TNF(Tumour Necrosis Factor) family;
184-312 4.12e-43

TNF(Tumour Necrosis Factor) family;


:

Pssm-ID: 425540  Cd Length: 127  Bit Score: 144.38  E-value: 4.12e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187063  184 SSWYHDR-GWAKISNMTLSNGKLRVNQDGFYYLYANICFRHHETSGSvptdYLQLMVYVVKTSIKIPSSHNLMKGGSTKN 262
Cdd:pfam00229   1 LSWESDRgGAFLLNGVTYSNGELVVPQAGLYYVYSQVYFRGEGCPSG----SVPLTHYLYKFSSSYPGPVLLLKGAESPC 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 342187063  263 WSGNSEFHFYSINVGGFFKLRAGEEISIQVSNPSLLDPD-QDATYFGAFKV 312
Cdd:pfam00229  77 SSENPEYWYQSIYLGGLFELRAGDRLSVNVSNPSLVDLSaPGKTYFGAFLL 127
 
Name Accession Description Interval E-value
TNF pfam00229
TNF(Tumour Necrosis Factor) family;
184-312 4.12e-43

TNF(Tumour Necrosis Factor) family;


Pssm-ID: 425540  Cd Length: 127  Bit Score: 144.38  E-value: 4.12e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187063  184 SSWYHDR-GWAKISNMTLSNGKLRVNQDGFYYLYANICFRHHETSGSvptdYLQLMVYVVKTSIKIPSSHNLMKGGSTKN 262
Cdd:pfam00229   1 LSWESDRgGAFLLNGVTYSNGELVVPQAGLYYVYSQVYFRGEGCPSG----SVPLTHYLYKFSSSYPGPVLLLKGAESPC 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 342187063  263 WSGNSEFHFYSINVGGFFKLRAGEEISIQVSNPSLLDPD-QDATYFGAFKV 312
Cdd:pfam00229  77 SSENPEYWYQSIYLGGLFELRAGDRLSVNVSNPSLVDLSaPGKTYFGAFLL 127
TNF cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT ...
 163-310 6.30e-41

Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal domain, a short transmembrane segment, an extracellular stalk, and a globular TNF-like extracellular domain of about 150 residues. They initiate apoptosis by binding to related receptors, some of which have intracellular death domains. They generally form homo- or hetero- trimeric complexes.TNF cytokines bind one elongated receptor molecule along each of three clefts formed by neighboring monomers of the trimer with ligand trimerization a requiste for receptor binding.


Pssm-ID: 238108  Cd Length: 137  Bit Score: 139.40  E-value: 6.30e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187063 163 PFAHLTINAASIpsgshKVTLSSWYHDRGWAKISN-MTLSNGKLRVNQDGFYYLYANICFRHHETSgsvptdYLQLMVYV 241
Cdd:cd00184    1 PAAHLIGTNSSS-----GGTGLSWESDDGRAFLSGgLELQNGELVVPQDGLYYIYSQVYFRGQCCS------TLSVSHVL 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 342187063 242 VKTSIKIPSSHNLMKGGSTKNWSGnSEFHFYSINVGGFFKLRAGEEISIQVSNPSLLDPDQDATYFGAF 310
Cdd:cd00184   70 QLRTDSYPEPILLLKGIRSVCSSV-SEGWYNSVYLGGLFQLRAGDRLSVNVSAPALLDLSQGTTFFGAF 137
TNF smart00207
Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric ...
 184-312 2.30e-40

Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor.


Pssm-ID: 214557  Cd Length: 125  Bit Score: 137.48  E-value: 2.30e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187063   184 SSWYHDRGWAKI-SNMTLSNGKLRVNQDGFYYLYANICFRHHETSGsvPTDYLQLMVYVVKTSIkiPSSHNLMKGGSTKN 262
Cdd:smart00207   1 LSWESDRGLASLlSGMELQNGELVVPRDGLYYIYSQVYFRGQGCNG--KSVELSLSLHLRKPSY--PLPLLLLEAARSSC 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 342187063   263 WSGNSEFHFYSInVGGFFKLRAGEEISIQVSNPSLLDPDQDATYFGAFKV 312
Cdd:smart00207  77 WSASSAWKDSVY-LGGLFPLTAGDRLSVNVTEPSLVDLAPGATFFGAFLV 125
 
Name Accession Description Interval E-value
TNF pfam00229
TNF(Tumour Necrosis Factor) family;
184-312 4.12e-43

TNF(Tumour Necrosis Factor) family;


Pssm-ID: 425540  Cd Length: 127  Bit Score: 144.38  E-value: 4.12e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187063  184 SSWYHDR-GWAKISNMTLSNGKLRVNQDGFYYLYANICFRHHETSGSvptdYLQLMVYVVKTSIKIPSSHNLMKGGSTKN 262
Cdd:pfam00229   1 LSWESDRgGAFLLNGVTYSNGELVVPQAGLYYVYSQVYFRGEGCPSG----SVPLTHYLYKFSSSYPGPVLLLKGAESPC 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 342187063  263 WSGNSEFHFYSINVGGFFKLRAGEEISIQVSNPSLLDPD-QDATYFGAFKV 312
Cdd:pfam00229  77 SSENPEYWYQSIYLGGLFELRAGDRLSVNVSNPSLVDLSaPGKTYFGAFLL 127
TNF cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT ...
 163-310 6.30e-41

Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal domain, a short transmembrane segment, an extracellular stalk, and a globular TNF-like extracellular domain of about 150 residues. They initiate apoptosis by binding to related receptors, some of which have intracellular death domains. They generally form homo- or hetero- trimeric complexes.TNF cytokines bind one elongated receptor molecule along each of three clefts formed by neighboring monomers of the trimer with ligand trimerization a requiste for receptor binding.


Pssm-ID: 238108  Cd Length: 137  Bit Score: 139.40  E-value: 6.30e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187063 163 PFAHLTINAASIpsgshKVTLSSWYHDRGWAKISN-MTLSNGKLRVNQDGFYYLYANICFRHHETSgsvptdYLQLMVYV 241
Cdd:cd00184    1 PAAHLIGTNSSS-----GGTGLSWESDDGRAFLSGgLELQNGELVVPQDGLYYIYSQVYFRGQCCS------TLSVSHVL 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 342187063 242 VKTSIKIPSSHNLMKGGSTKNWSGnSEFHFYSINVGGFFKLRAGEEISIQVSNPSLLDPDQDATYFGAF 310
Cdd:cd00184   70 QLRTDSYPEPILLLKGIRSVCSSV-SEGWYNSVYLGGLFQLRAGDRLSVNVSAPALLDLSQGTTFFGAF 137
TNF smart00207
Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric ...
 184-312 2.30e-40

Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor.


Pssm-ID: 214557  Cd Length: 125  Bit Score: 137.48  E-value: 2.30e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187063   184 SSWYHDRGWAKI-SNMTLSNGKLRVNQDGFYYLYANICFRHHETSGsvPTDYLQLMVYVVKTSIkiPSSHNLMKGGSTKN 262
Cdd:smart00207   1 LSWESDRGLASLlSGMELQNGELVVPRDGLYYIYSQVYFRGQGCNG--KSVELSLSLHLRKPSY--PLPLLLLEAARSSC 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 342187063   263 WSGNSEFHFYSInVGGFFKLRAGEEISIQVSNPSLLDPDQDATYFGAFKV 312
Cdd:smart00207  77 WSASSAWKDSVY-LGGLFPLTAGDRLSVNVTEPSLVDLAPGATFFGAFLV 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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