|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
1346-1871 |
2.87e-161 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 510.92 E-value: 2.87e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1346 EAFSIPVPISADLRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVASDHynrqklfeESGSPKfahvPSLIVC 1425
Cdd:COG0553 230 ALESLPAGLKATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELK--------ERGLAR----PVLIVA 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1426 PSTLAGHWQQELSTYAPFLKVSAYVGPpAERAKIRSKMKKSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAK 1505
Cdd:COG0553 298 PTSLVGNWQRELAKFAPGLRVLVLDGT-RERAKGANPFEDADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATK 376
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1506 LTKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIAASRDAkssskerergtlALEAIHKQ 1585
Cdd:COG0553 377 RAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKGDEE------------ALERLRRL 444
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1586 VLPFMLRRLKEDVLADLPPKIIQDYYCDMSDLQRKLLNDFVSQLnineeleDDETEKTQGTRkkksQKAHIFQALQYMRK 1665
Cdd:COG0553 445 LRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALYEAVLEYL-------RRELEGAEGIR----RRGLILAALTRLRQ 513
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1666 LCNHPALILTEKHPKRNaivkqlakensglhdlkHAPKLTALGQLLRDcglgnssVNSNGidsaltnavseHRVLIFCQL 1745
Cdd:COG0553 514 ICSHPALLLEEGAELSG-----------------RSAKLEALLELLEE-------LLAEG-----------EKVLVFSQF 558
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1746 KDMLDMVEKDLLQAtmpDVTYMRLDGSVEPTKRQEAVTKFNNDPSIDVLLLTTHVGGLGLNLTGADTVIFVEHDWNPMRD 1825
Cdd:COG0553 559 TDTLDLLEERLEER---GIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVE 635
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 81170682 1826 LQAMDRAHRIGQKKVVNVYRLITRGCLEEKIMGLQRFKMNVASTVV 1871
Cdd:COG0553 636 EQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVL 681
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
1358-1593 |
1.25e-147 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 455.27 E-value: 1.25e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVASDHYNRQKLFEesgspkFAHVPSLIVCPSTLAGHWQQEL 1437
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILASDHHKRANSFN------SENLPSLVVCPPTLVGHWVAEI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1438 STYAP--FLKVSAYVGPPAERAKIRSKMKKSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLTKAVKSLRS 1515
Cdd:cd17999 75 KKYFPnaFLKPLAYVGPPQERRRLREQGEKHNVIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKA 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81170682 1516 YHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIAASRDAKSSSKERERGTLALEAIHKQVLPFMLRR 1593
Cdd:cd17999 155 NHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDSKASAKEQEAGALALEALHKQVLPFLLRR 232
|
|
| DUF3535 |
pfam12054 |
Domain of unknown function (DUF3535); This presumed domain is functionally uncharacterized. ... |
688-1144 |
1.52e-129 |
|
Domain of unknown function (DUF3535); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 439 to 459 amino acids in length. This domain is found associated with pfam00271, pfam02985, pfam00176. This domain has two completely conserved residues (P and K) that may be functionally important.
Pssm-ID: 463447 Cd Length: 445 Bit Score: 413.95 E-value: 1.52e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 688 DGPESFSKLLYSHIEPMLKVSITPIGSfrrpyPLDTTLIVKPSGQPYAPSTSRERNNNISELSNSRTKHRAKDDPKGSfc 767
Cdd:pfam12054 10 KPPEALLHAFCPHLSPWLTLLMTPIGV-----PMDASLLLKPSGQPYSPPERRKSKKKEEPPPSDIPSPGRQGSSSHN-- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 768 fsVDEPMLNGDVEFVGEERMLKARLRASSLLGRIIGRWKRDEILLFFKPFLQACLTSSFSTPVVLGSRLIESFFEVE--- 844
Cdd:pfam12054 83 --VDKPMIGGDVTLVGMDVVIRTRIAAAKALGLLLSYWPEESPLDFFTKLLLPYLNSPSALQRLLAAIIIEEWAKNCkke 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 845 -DNDLTIQKDELYHLLCDQFATVPR-ENYANLVSQLHVVRAQCNALLNTFLDVGRLSRSKIPSLAVVVKGDPEAGPIAFG 922
Cdd:pfam12054 161 kSSSVSTLPETLSEKLLEILENPSRpPYYRELVPYLTRLRTQCQQLLNTFRDVGKVSQSKLPKLAVVVQGEPEAGPGAFS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 923 IADAEKLVGPTYENLCKLLSPSQKAQSSKALNEIKYLIIDEISIYKIAKERQDIQCSASIASAMVTYDKLPKKLNSIIKG 1002
Cdd:pfam12054 241 IEQAEKLVGEDYDKLKKSLSPKQKLLALQQLEDRRRRVQAAIEEAKEAKEQRDVRVLAAAAGALVALKGLPKKLNPIIKP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1003 IMESIKKEQFSCLQMHSASAMMKLISACYKESRQVISEKIVRNLCAYVCMDTTETPIFHD--SGKNGILSLHSIGTSDDN 1080
Cdd:pfam12054 321 LMDSIKKEENEELQQRSADALAHLIDLCVDRGKPGPNDKIVKNLCTFLCVDTSETPEFHPnaKLTDGILTLRKEEDKADH 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81170682 1081 DEQVSGKlvddsddvsndrksslssvSDKDAAVLQRMGAQLTLQQMAQNFGSSLFSRVPVLSQC 1144
Cdd:pfam12054 401 ADAAKFE-------------------EEAKEARIQRRGAKLALEQLAKKFGASLFEKVPKLWEL 445
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
1356-1595 |
5.37e-91 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 294.47 E-value: 5.37e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1356 ADLRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVASDHynrqklfeESGSPKfahvPSLIVCPSTLAGHWQQ 1435
Cdd:cd18012 3 ATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRK--------EEGRKG----PSLVVAPTSLIYNWEE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1436 ELSTYAPFLKVSAYVGPPAERAKIRSkMKKSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLTKAVKSLRS 1515
Cdd:cd18012 71 EAAKFAPELKVLVIHGTKRKREKLRA-LEDYDLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1516 YHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIAASRDAKssskerergtlALEAIHKQVLPFMLRRLK 1595
Cdd:cd18012 150 DHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDGDEE-----------ALEELKKLISPFILRRLK 218
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
1351-1873 |
1.49e-84 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 301.72 E-value: 1.49e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1351 PVPISADLRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVASDHYNRQKlfeeSGspkfahvPSLIVCPSTLA 1430
Cdd:PLN03142 163 PSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEYRGI----TG-------PHMVVAPKSTL 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1431 GHWQQELSTYAPFLKVSAYVGPPAERAKIRSKM---KKSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLT 1507
Cdd:PLN03142 232 GNWMNEIRRFCPVLRAVKFHGNPEERAHQREELlvaGKFDVCVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLS 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1508 KAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFvrpiaasrdakSSSKERERGTLaLEAIHKQVL 1587
Cdd:PLN03142 312 KTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWF-----------QISGENDQQEV-VQQLHKVLR 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1588 PFMLRRLKEDVLADLPPKIIQDYYCDMSDLQRKLLNDFVSQlnineeleDDETEKTQGTRKKksqkahIFQALQYMRKLC 1667
Cdd:PLN03142 380 PFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQK--------DLDVVNAGGERKR------LLNIAMQLRKCC 445
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1668 NHPALIL-TEKHPKRnaivkqlakeNSGLHDLKHAPKLTALGQLLRDCGLGNSsvnsngidsaltnavsehRVLIFCQLK 1746
Cdd:PLN03142 446 NHPYLFQgAEPGPPY----------TTGEHLVENSGKMVLLDKLLPKLKERDS------------------RVLIFSQMT 497
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1747 DMLDMVEKDLLQATMPdvtYMRLDGSVEPTKRQEAVTKFNNDPSID-VLLLTTHVGGLGLNLTGADTVIFVEHDWNPMRD 1825
Cdd:PLN03142 498 RLLDILEDYLMYRGYQ---YCRIDGNTGGEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLATADIVILYDSDWNPQVD 574
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 81170682 1826 LQAMDRAHRIGQKKVVNVYRLITRGCLEEKIMGLQRFKMNVASTVVNQ 1873
Cdd:PLN03142 575 LQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQ 622
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
1361-1673 |
1.59e-82 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 273.41 E-value: 1.59e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1361 YQQEGVNWLAFL-NKYELHGILCDDMGLGKTLQTICIVAsdhynrqKLFEESgspKFAHVPSLIVCPSTLAGHWQQELST 1439
Cdd:pfam00176 1 YQIEGVNWMLSLeNNLGRGGILADEMGLGKTLQTISLLL-------YLKHVD---KNWGGPTLIVVPLSLLHNWMNEFER 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1440 YA--PFLKVSAYVGPPAERAKIRSKMK---KSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLTKAVKSLR 1514
Cdd:pfam00176 71 WVspPALRVVVLHGNKRPQERWKNDPNflaDFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1515 SYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIAASRDAKSSSKerergtlaleaIHKQVLPFMLRRL 1594
Cdd:pfam00176 151 TRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKKGVSR-----------LHKLLKPFLLRRT 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81170682 1595 KEDVLADLPPKIIQDYYCDMSDLQRKLLNDFVSQLNINeeleddeteKTQGTRKKKSQKAHIFQALQYMRKLCNHPALI 1673
Cdd:pfam00176 220 KKDVEKSLPPKVEYILFCRLSKLQRKLYQTFLLKKDLN---------AIKTGEGGREIKASLLNILMRLRKICNHPGLI 289
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
1358-1545 |
8.67e-71 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 235.15 E-value: 8.67e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVASdhynrqkLFEESGSPKfahvPSLIVCPSTLAGHWQQEL 1437
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAY-------LLKEGKERG----PVLVVCPLSVLENWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1438 STYAPFLKVSAYVGPPAERAKIRSKMK--KSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLTKAVKSLRS 1515
Cdd:cd17919 70 EKWTPDLRVVVYHGSQRERAQIRAKEKldKFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRA 149
|
170 180 190
....*....|....*....|....*....|
gi 81170682 1516 YHRLILSGTPIQNNVLELWSLFDFLMPGFL 1545
Cdd:cd17919 150 KRRLLLTGTPLQNNLEELWALLDFLDPPFL 179
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
1358-1593 |
5.90e-62 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 211.85 E-value: 5.90e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLaflnkYELH-----GILCDDMGLGKTLQTICIVASdhynrqkLFEEsgspKFAHvPSLIVCPSTLAGH 1432
Cdd:cd18001 1 LYPHQREGVAWL-----WSLHdggkgGILADDMGLGKTVQICAFLSG-------MFDS----GLIK-SVLVVMPTSLIPH 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1433 WQQELSTYAPFLKVSAYVGP-PAERAKIRSKMKKS-DVVVTSYDICRNDVDELVKID-----WNYCVLDEGHVIKNARAK 1505
Cdd:cd18001 64 WVKEFAKWTPGLRVKVFHGTsKKERERNLERIQRGgGVLLTTYGMVLSNTEQLSADDhdefkWDYVILDEGHKIKNSKTK 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1506 LTKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPG-FLGTEKTFQERFVRPIAASRDAKSSSKERERGTLALEAIHK 1584
Cdd:cd18001 144 SAKSLREIPAKNRIILTGTPIQNNLKELWALFDFACNGsLLGTRKTFKMEFENPITRGRDKDATQGEKALGSEVAENLRQ 223
|
....*....
gi 81170682 1585 QVLPFMLRR 1593
Cdd:cd18001 224 IIKPYFLRR 232
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
1358-1593 |
2.52e-59 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 204.92 E-value: 2.52e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVAS---------DHYNRQKLFEESGSPKFAHVPSLIVCPST 1428
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAvlgktgtrrDRENNRPRFKKKPPASSAKKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1429 LAGHWQQELSTYAPFlKVSAYVGPPAERAKI-RSKMKKSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLT 1507
Cdd:cd18005 81 VLYNWKDELDTWGHF-EVGVYHGSRKDDELEgRLKAGRLEVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPKSKLT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1508 KAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIAASRDAKSSSKERERGTLALEAIHKQVL 1587
Cdd:cd18005 160 QAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRKRKQELAVKLS 239
|
....*.
gi 81170682 1588 PFMLRR 1593
Cdd:cd18005 240 KFFLRR 245
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
1358-1545 |
5.17e-58 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 199.09 E-value: 5.17e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLaflnkYELH-----GILCDDMGLGKTLQTICIVASDHYNRQKLfeesgspkfahVPSLIVCPSTLAGH 1432
Cdd:cd18000 1 LFKYQQTGVQWL-----WELHcqrvgGILGDEMGLGKTIQIIAFLAALHHSKLGL-----------GPSLIVCPATVLKQ 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1433 WQQELSTYAPFLKV------SAYVGPP-------AERAKIRSKMKKSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVI 1499
Cdd:cd18000 65 WVKEFHRWWPPFRVvvlhssGSGTGSEeklgsieRKSQLIRKVVGDGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKI 144
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 81170682 1500 KNARAKLTKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFL 1545
Cdd:cd18000 145 RNPDAEITLACKQLRTPHRLILSGTPIQNNLKELWSLFDFVFPPYL 190
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
1357-1595 |
2.35e-56 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 195.67 E-value: 2.35e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1357 DLRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVAsdhYnrqkLFEEsgspKFAHVPSLIVCP-STLAGhWQQ 1435
Cdd:cd17996 3 TLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLIT---Y----LMEK----KKNNGPYLVIVPlSTLSN-WVS 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1436 ELSTYAPFLKVSAYVGPPAERAKIRSKMK--KSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLTKAVKS- 1512
Cdd:cd17996 71 EFEKWAPSVSKIVYKGTPDVRKKLQSQIRagKFNVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTy 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1513 LRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIAASRDAKSSSKERERGTLALEAIHKQVLPFMLR 1592
Cdd:cd17996 151 YHARYRLLLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFANTGEQVKIELNEEETLLIIRRLHKVLRPFLLR 230
|
...
gi 81170682 1593 RLK 1595
Cdd:cd17996 231 RLK 233
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
1358-1595 |
4.14e-56 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 195.30 E-value: 4.14e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVAsdhynrqkLFEESGSPKfahvPSLIVCP-STLaGHWQQE 1436
Cdd:cd18009 4 MRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLA--------HLRERGVWG----PFLVIAPlSTL-PNWVNE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1437 LSTYAPFLKVSAYVGPPAERAKIRSKMKKSD-------VVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLTKA 1509
Cdd:cd18009 71 FARFTPSVPVLLYHGTKEERERLRKKIMKREgtlqdfpVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1510 VKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERF-VRPIAASRDAKSSSKErERGTLALEAIHKQVLP 1588
Cdd:cd18009 151 LKTFNSDNRLLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFdFSSLSDNAADISNLSE-EREQNIVHMLHAILKP 229
|
....*..
gi 81170682 1589 FMLRRLK 1595
Cdd:cd18009 230 FLLRRLK 236
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
1696-1847 |
2.44e-54 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 186.14 E-value: 2.44e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1696 HDLKHAPKLTALGQLLRDCGLGNssvnsngidsaltnavseHRVLIFCQLKDMLDMVEKDLLQAtmpDVTYMRLDGSVEP 1775
Cdd:cd18793 5 IEEVVSGKLEALLELLEELREPG------------------EKVLIFSQFTDTLDILEEALRER---GIKYLRLDGSTSS 63
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81170682 1776 TKRQEAVTKFNNDPSIDVLLLTTHVGGLGLNLTGADTVIFVEHDWNPMRDLQAMDRAHRIGQKKVVNVYRLI 1847
Cdd:cd18793 64 KERQKLVDRFNEDPDIRVFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
1358-1593 |
4.13e-53 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 186.02 E-value: 4.13e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVASdHYNRQKLfeesgspkfaHVPSLIVCP-STLAGhWQQE 1436
Cdd:cd17993 2 LRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSY-LFHSQQQ----------YGPFLVVVPlSTMPA-WQRE 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1437 LSTYAPFLKVSAYVGPPAERAKIR--------SKMKKSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLTK 1508
Cdd:cd17993 70 FAKWAPDMNVIVYLGDIKSRDTIReyefyfsqTKKLKFNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1509 AVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQErfvrpiaasrdakSSSKERERGtlaLEAIHKQVLP 1588
Cdd:cd17993 150 ALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEE-------------EHDEEQEKG---IADLHKELEP 213
|
....*
gi 81170682 1589 FMLRR 1593
Cdd:cd17993 214 FILRR 218
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
1358-1593 |
4.49e-53 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 186.02 E-value: 4.49e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVAsdHYNRQKlfEESGspkfahvPSLIVCPSTLAGHWQQEL 1437
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLA--HLACEK--GNWG-------PHLIVVPTSVMLNWEMEF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1438 STYAPFLKVSAYVGPPAERAKIRSKMKKSD---VVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLTKAVKSLR 1514
Cdd:cd18003 70 KRWCPGFKILTYYGSAKERKLKRQGWMKPNsfhVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFN 149
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81170682 1515 SYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIaasrDAKSSSKERERGTLaLEAIHKQVLPFMLRR 1593
Cdd:cd18003 150 TQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPL----TAMSEGSQEENEEL-VRRLHKVLRPFLLRR 223
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
1358-1593 |
1.13e-50 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 178.98 E-value: 1.13e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFlNKYELHG-ILCDDMGLGKTLQTICIVasdhynrQKLFEESGSpkfaHVPSLIVCP-STLaGHWQQ 1435
Cdd:cd17995 1 LRDYQLEGVNWLLF-NWYNRRNcILADEMGLGKTIQSIAFL-------EHLYQVEGI----RGPFLVIAPlSTI-PNWQR 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1436 ELSTYAPfLKVSAYVGPPAERAKIR--------------SKMKKSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKN 1501
Cdd:cd17995 68 EFETWTD-MNVVVYHGSGESRQIIQqyemyfkdaqgrkkKGVYKFDVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKN 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1502 ARAKLTKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFvrpiaasRDAKSSSKerergtlaLEA 1581
Cdd:cd17995 147 RNSKLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEF-------GDLKTAEQ--------VEK 211
|
250
....*....|..
gi 81170682 1582 IHKQVLPFMLRR 1593
Cdd:cd17995 212 LQALLKPYMLRR 223
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
1358-1595 |
9.04e-50 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 176.36 E-value: 9.04e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVAS-DHYNRQklfeeSGspkfahvPSLIVCP-STLaGHWQQ 1435
Cdd:cd17997 4 MRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYlKHYKNI-----NG-------PHLIIVPkSTL-DNWMR 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1436 ELSTYAPFLKVSAYVGPPAERAKI---RSKMKKSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLTKAVKS 1512
Cdd:cd17997 71 EFKRWCPSLRVVVLIGDKEERADIirdVLLPGKFDVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1513 LRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFvrpiaaSRDAKSSSKERergtlALEAIHKQVLPFMLR 1592
Cdd:cd17997 151 FNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWF------NVNNCDDDNQE-----VVQRLHKVLRPFLLR 219
|
...
gi 81170682 1593 RLK 1595
Cdd:cd17997 220 RIK 222
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
1358-1593 |
9.77e-50 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 177.09 E-value: 9.77e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLaflnkyeLH--GILCDDMGLGKTLQTICIVASDHYNRQKLFEE----SGSPKFAHVPS--LIVCPSTL 1429
Cdd:cd18008 1 LLPYQKQGLAWM-------LPrgGILADEMGLGKTIQALALILATRPQDPKIPEEleenSSDPKKLYLSKttLIVVPLSL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1430 AGHWQQELS--TYAPFLKVSAYVGPpaERAKIRSKMKKSDVVVTSYDICRND----------------VDELVKIDWNYC 1491
Cdd:cd18008 74 LSQWKDEIEkhTKPGSLKVYVYHGS--KRIKSIEELSDYDIVITTYGTLASEfpknkkgggrdskekeASPLHRIRWYRV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1492 VLDEGHVIKNARAKLTKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIAASRDAkssske 1571
Cdd:cd18008 152 ILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPFSKNDRK------ 225
|
250 260
....*....|....*....|..
gi 81170682 1572 rergtlALEAIHKQVLPFMLRR 1593
Cdd:cd18008 226 ------ALERLQALLKPILLRR 241
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
1358-1593 |
7.48e-48 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 171.70 E-value: 7.48e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWL----AFLNKYELHG-ILCDDMGLGKTLQTICIVasdhYN--RQKLFEESGSPKFahvpsLIVCPSTLA 1430
Cdd:cd18004 1 LRPHQREGVQFLydclTGRRGYGGGGaILADEMGLGKTLQAIALV----WTllKQGPYGKPTAKKA-----LIVCPSSLV 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1431 GHWQQELSTYAP--FLKVSAYVGPPAERAKIRSKM---KKSDVVVTSYDICRNDVDELVK-IDWNYCVLDEGHVIKNARA 1504
Cdd:cd18004 72 GNWKAEFDKWLGlrRIKVVTADGNAKDVKASLDFFssaSTYPVLIISYETLRRHAEKLSKkISIDLLICDEGHRLKNSES 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1505 KLTKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIAASRDAKSSSKERERGTLALEAIHK 1584
Cdd:cd18004 152 KTTKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQELSE 231
|
....*....
gi 81170682 1585 QVLPFMLRR 1593
Cdd:cd18004 232 LTSRFILRR 240
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
1358-1593 |
1.25e-46 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 167.68 E-value: 1.25e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVA--SDHYNRQKlfeesgspkfahvPSLIVCPSTLAGHWQQ 1435
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAhlAEEHNIWG-------------PFLVIAPASTLHNWQQ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1436 ELSTYAPFLKVSAYVGPPAERAKIR-----SKMKKSD----VVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKL 1506
Cdd:cd18002 68 EISRFVPQFKVLPYWGNPKDRKVLRkfwdrKNLYTRDapfhVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSR 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1507 TKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIAASRDAKSSSKERErgtlaLEAIHKQV 1586
Cdd:cd18002 148 WKTLLSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKTGLNEHQ-----LKRLHMIL 222
|
....*..
gi 81170682 1587 LPFMLRR 1593
Cdd:cd18002 223 KPFMLRR 229
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
1358-1542 |
7.79e-45 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 161.01 E-value: 7.79e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVAsdhynrqkLFEESGSPKfahvPSLIVCPSTLAGHWQQEL 1437
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLA--------YLKEIGIPG----PHLVVVPSSTLDNWLREF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1438 STYAPFLKVSAYVGPPAERAKIR----SKMKKSDVVVTSYDICRNDVDE---LVKIDWNYCVLDEGHVIKNARAKLTKAV 1510
Cdd:cd17998 69 KRWCPSLKVEPYYGSQEERKHLRydilKGLEDFDVIVTTYNLATSNPDDrsfFKRLKLNYVVYDEGHMLKNMTSERYRHL 148
|
170 180 190
....*....|....*....|....*....|..
gi 81170682 1511 KSLRSYHRLILSGTPIQNNVLELWSLFDFLMP 1542
Cdd:cd17998 149 MTINANFRLLLTGTPLQNNLLELMSLLNFIMP 180
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
1358-1593 |
4.48e-44 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 159.91 E-value: 4.48e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVAsdhYNRQKLFEESgspkfahvPSLIVCPSTLAGHWQQEL 1437
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLW---YLAGRLKLLG--------PFLVLCPLSVLDNWKEEL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1438 STYAPFLKVSAYVGPPAERAKIRSKMKKS---DVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLTKAVKSLR 1514
Cdd:cd18006 70 NRFAPDLSVITYMGDKEKRLDLQQDIKSTnrfHVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFS 149
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81170682 1515 SYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTfqERFVRPIAASRDAKSSSKErergtlaleaIHKQVLPFMLRR 1593
Cdd:cd18006 150 VDFRLLLTGTPIQNSLQELYALLSFIEPNVFPKDKL--DDFIKAYSETDDESETVEE----------LHLLLQPFLLRR 216
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
1358-1605 |
4.00e-41 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 152.51 E-value: 4.00e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVASDHYNRQklfeesgspkfAHVPSLIVCPSTLAGHWQQEL 1437
Cdd:cd18064 16 LRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRN-----------IPGPHMVLVPKSTLHNWMAEF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1438 STYAPFLKVSAYVGPPAERAK-IRSKM--KKSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLTKAVKSLR 1514
Cdd:cd18064 85 KRWVPTLRAVCLIGDKDQRAAfVRDVLlpGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFK 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1515 SYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFvrpiaasrDAKSSSKERErgtlALEAIHKQVLPFMLRRL 1594
Cdd:cd18064 165 TTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWF--------DTNNCLGDQK----LVERLHMVLRPFLLRRI 232
|
250
....*....|.
gi 81170682 1595 KEDVLADLPPK 1605
Cdd:cd18064 233 KADVEKSLPPK 243
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
1355-1593 |
2.47e-40 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 150.16 E-value: 2.47e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1355 SADLRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVaSDHYNRQKLFEesgspkfahvPSLIVCPSTLAGHWQ 1434
Cdd:cd18054 18 NLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFL-SYLFHQHQLYG----------PFLLVVPLSTLTSWQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1435 QELSTYAPFLKVSAYVGPPAERAKIR--------SKMKKSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKL 1506
Cdd:cd18054 87 REFEIWAPEINVVVYIGDLMSRNTIReyewihsqTKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1507 TKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQErfvrpiaasrdakSSSKERERGtlaLEAIHKQV 1586
Cdd:cd18054 167 YKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEE-------------DHGKGRENG---YQSLHKVL 230
|
....*..
gi 81170682 1587 LPFMLRR 1593
Cdd:cd18054 231 EPFLLRR 237
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
1354-1595 |
6.95e-40 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 149.06 E-value: 6.95e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1354 ISADLRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVASdhynrqkLFEEsgspKFAHVPSLIVCPSTLAGHW 1433
Cdd:cd18063 20 INGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITY-------LMEH----KRLNGPYLIIVPLSTLSNW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1434 QQELSTYAPFLKVSAYVGPPAERAKIRSKMK--KSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLTKAVK 1511
Cdd:cd18063 89 TYEFDKWAPSVVKISYKGTPAMRRSLVPQLRsgKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLN 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1512 S-LRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIAASrdAKSSSKERERGTLALEAIHKQVLPFM 1590
Cdd:cd18063 169 ThYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT--GERVDLNEEETILIIRRLHKVLRPFL 246
|
....*
gi 81170682 1591 LRRLK 1595
Cdd:cd18063 247 LRRLK 251
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
1354-1595 |
3.28e-39 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 147.11 E-value: 3.28e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1354 ISADLRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVASdhynrqkLFEEsgspKFAHVPSLIVCPSTLAGHW 1433
Cdd:cd18062 20 VNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITY-------LMEH----KRINGPFLIIVPLSTLSNW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1434 QQELSTYAPFLKVSAYVGPPAERAKIRSKMK--KSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLTKAVK 1511
Cdd:cd18062 89 VYEFDKWAPSVVKVSYKGSPAARRAFVPQLRsgKFNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKLTQVLN 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1512 S-LRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIAASrdAKSSSKERERGTLALEAIHKQVLPFM 1590
Cdd:cd18062 169 ThYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT--GEKVDLNEEETILIIRRLHKVLRPFL 246
|
....*
gi 81170682 1591 LRRLK 1595
Cdd:cd18062 247 LRRLK 251
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
1358-1595 |
7.25e-38 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 142.85 E-value: 7.25e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVASDHYNRQklfeesgspkfAHVPSLIVCPSTLAGHWQQEL 1437
Cdd:cd18065 16 LRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRN-----------IPGPHMVLVPKSTLHNWMNEF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1438 STYAPFLKVSAYVGPPAERAK-IRSKMKKS--DVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLTKAVKSLR 1514
Cdd:cd18065 85 KRWVPSLRAVCLIGDKDARAAfIRDVMMPGewDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFK 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1515 SYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFvrpiaasrDAKSSSKERErgtlALEAIHKQVLPFMLRRL 1594
Cdd:cd18065 165 TTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWF--------DTKNCLGDQK----LVERLHAVLKPFLLRRI 232
|
.
gi 81170682 1595 K 1595
Cdd:cd18065 233 K 233
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
1358-1593 |
2.97e-35 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 135.68 E-value: 2.97e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWL----AFLNKYELHG-ILCDDMGLGKTLQTICIVASdhynrqkLFEESGSPKFAHVPSLIVCPSTLAGH 1432
Cdd:cd18067 1 LRPHQREGVKFLyrcvTGRRIRGSHGcIMADEMGLGKTLQCITLMWT-------LLRQSPQCKPEIDKAIVVSPSSLVKN 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1433 WQQELSTY-----APFL---KVSAYVGPPAER-AKIRSKMKKSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNAR 1503
Cdd:cd18067 74 WANELGKWlggrlQPLAidgGSKKEIDRKLVQwASQQGRRVSTPVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSD 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1504 AKLTKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIAASRDAKSSSKERERGTLALEAIH 1583
Cdd:cd18067 154 NQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKGRDADASEKERQLGEEKLQELI 233
|
250
....*....|
gi 81170682 1584 KQVLPFMLRR 1593
Cdd:cd18067 234 SIVNRCIIRR 243
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
1355-1593 |
7.27e-35 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 134.41 E-value: 7.27e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1355 SADLRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVasdhynrQKLFEESGspkfAHVPSLIVCPSTLAGHWQ 1434
Cdd:cd18053 18 GLELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFL-------NYLFHEHQ----LYGPFLLVVPLSTLTSWQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1435 QELSTYAPFLKVSAYVGPPAERAKIRS--------KMKKSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKL 1506
Cdd:cd18053 87 REIQTWAPQMNAVVYLGDINSRNMIRThewmhpqtKRLKFNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1507 TKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERfvrpiaasrdaksSSKERERGTLALeaiHKQV 1586
Cdd:cd18053 167 YKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEE-------------HGKGREYGYASL---HKEL 230
|
....*..
gi 81170682 1587 LPFMLRR 1593
Cdd:cd18053 231 EPFLLRR 237
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
1379-1593 |
9.93e-35 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 133.75 E-value: 9.93e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1379 GILCDDMGLGKTLQTICIVASDhynrqklfeesgspkfahvPSLIVCPSTLAGHW--QQELSTYAPFLKVSAYVGPpaER 1456
Cdd:cd18071 51 GILADDMGLGKTLTTISLILAN-------------------FTLIVCPLSVLSNWetQFEEHVKPGQLKVYTYHGG--ER 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1457 AKIRSKMKKSDVVVTSYDICRNDV-----DELVKIDWNYCVLDEGHVIKNARAKLTKAVKSLRSYHRLILSGTPIQNNVL 1531
Cdd:cd18071 110 NRDPKLLSKYDIVLTTYNTLASDFgakgdSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPK 189
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81170682 1532 ELWSLFDFLMPGFLGTEKTFQERFVRPIAASRDAKSSSkerergtlaLEAIHKQVLpfmLRR 1593
Cdd:cd18071 190 DLGSLLSFLHLKPFSNPEYWRRLIQRPLTMGDPTGLKR---------LQVLMKQIT---LRR 239
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
1358-1573 |
1.02e-34 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 133.96 E-value: 1.02e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWL------AFLNKYELHG-ILCDDMGLGKTLQTICIVASdhYNRQklfeesgSPKFAHVpsLIVCPSTLA 1430
Cdd:cd18007 1 LKPHQVEGVRFLwsnlvgTDVGSDEGGGcILAHTMGLGKTLQVITFLHT--YLAA-------APRRSRP--LVLCPASTL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1431 GHWQQELSTYAPFLKVSAYVGPPAERA--------KIRSKMKKSDVVVTSYDICRN--------------DVDELVKIDW 1488
Cdd:cd18007 70 YNWEDEFKKWLPPDLRPLLVLVSLSASkradarlrKINKWHKEGGVLLIGYELFRNlasnattdprlkqeFIAALLDPGP 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1489 NYCVLDEGHVIKNARAKLTKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIAASRDAKSS 1568
Cdd:cd18007 150 DLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPIEAGQCVDST 229
|
....*
gi 81170682 1569 SKERE 1573
Cdd:cd18007 230 EEDVR 234
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
1358-1593 |
4.60e-34 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 131.89 E-value: 4.60e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLaflnkYE----------LHGILCDDMGLGKTLQTICIVasdhYNRQKLFEESGSPKFAHVpsLIVCPS 1427
Cdd:cd18066 1 LRPHQREGIEFL-----YEcvmgmrvnerFGAILADEMGLGKTLQCISLI----WTLLRQGPYGGKPVIKRA--LIVTPG 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1428 TLAGHWQQELSTYAPFLKVSAYVGPPAERAKIRSKMKKSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLT 1507
Cdd:cd18066 70 SLVKNWKKEFQKWLGSERIKVFTVDQDHKVEEFIASPLYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTT 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1508 KAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIAASRDAKSSSKERERGTLALEAIHKQVL 1587
Cdd:cd18066 150 TALTSLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPTATPEEKKLGEARAAELTRLTG 229
|
....*.
gi 81170682 1588 PFMLRR 1593
Cdd:cd18066 230 LFILRR 235
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
1358-1593 |
1.53e-33 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 129.63 E-value: 1.53e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNW-LAFlnkyELHGILCDDMGLGKTLQTICIVAsdHYNrqklfeesgspkfAHVPSLIVCPSTLAGHWQQE 1436
Cdd:cd18010 1 LLPFQREGVCFaLRR----GGRVLIADEMGLGKTVQAIAIAA--YYR-------------EEWPLLIVCPSSLRLTWADE 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1437 LSTYAPFLKvsayvgPPAER----AKIRSKMKKSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLTKAVKS 1512
Cdd:cd18010 62 IERWLPSLP------PDDIQvivkSKDGLRDGDAKVVIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALP 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1513 L--RSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIAASR--DAKSSSKERERGTLALEAIhkqvlp 1588
Cdd:cd18010 136 LlkRAKRVILLSGTPALSRPIELFTQLDALDPKLFGRFHDFGRRYCAAKQGGFgwDYSGSSNLEELHLLLLATI------ 209
|
....*
gi 81170682 1589 fMLRR 1593
Cdd:cd18010 210 -MIRR 213
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
1358-1593 |
7.71e-33 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 126.79 E-value: 7.71e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVASdhynrqkLFEESGSPKfahvPSLIVCPSTLAGHWQQEL 1437
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYS-------LYKEGHSKG----PFLVSAPLSTIINWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1438 STYAPFLKVSAYVGppaerakirskmkkSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKLTKAVKSLRSYH 1517
Cdd:cd17994 70 EMWAPDFYVVTYVG--------------DHVLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGY 135
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81170682 1518 RLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFvrpiaasrdaKSSSKERErgtlaLEAIHKQVLPFMLRR 1593
Cdd:cd17994 136 KLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGFLEEF----------ADISKEDQ-----IKKLHDLLGPHMLRR 196
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
1358-1593 |
9.52e-32 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 124.77 E-value: 9.52e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVAsdhynrqKLFEESgspkfAHVPSLIVCPSTLAGHWQQEL 1437
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLS-------EIFLMG-----IRGPFLIIAPLSTITNWEREF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1438 STYAPfLKVSAYVGPPAERAKIR--------------SKMKKSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNAR 1503
Cdd:cd18058 69 RTWTE-MNAIVYHGSQISRQMIQqyemyyrdeqgnplSGIFKFQVVITTFEMILADCPELKKINWSCVIIDEAHRLKNRN 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1504 AKLTKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFvrpiaasRDAKSSSKERErgtlaLEAIH 1583
Cdd:cd18058 148 CKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEF-------GDLKTEEQVKK-----LQSIL 215
|
250
....*....|
gi 81170682 1584 KqvlPFMLRR 1593
Cdd:cd18058 216 K---PMMLRR 222
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
1358-1593 |
4.64e-31 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 122.83 E-value: 4.64e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFlNKYELHG-ILCDDMGLGKTLQTICIVASDHYnrqklfeesgspKFAHVPSLIVCPSTLAGHWQQE 1436
Cdd:cd18059 1 LREYQLEGVNWLLF-NWYNTRNcILADEMGLGKTIQSITFLYEIYL------------KGIHGPFLVIAPLSTIPNWERE 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1437 LSTYAPfLKVSAYVGPPAERAKIRS-KMKKSD-------------VVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNA 1502
Cdd:cd18059 68 FRTWTE-LNVVVYHGSQASRRTIQLyEMYFKDpqgrvikgsykfhAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNR 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1503 RAKLTKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFvrpiaasRDAKSSSKERErgtlaLEAI 1582
Cdd:cd18059 147 NCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEF-------GDLKTEEQVQK-----LQAI 214
|
250
....*....|.
gi 81170682 1583 HKqvlPFMLRR 1593
Cdd:cd18059 215 LK---PMMLRR 222
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
1358-1540 |
2.03e-30 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 121.43 E-value: 2.03e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFL-NKYELHGILCDDMGLGKTLQTICIVASDHYNRQKLFEESGSPKFAH--------VPS---LIVC 1425
Cdd:cd18072 1 LLLHQKQALAWLLWReRQKPRGGILADDMGLGKTLTMIALILAQKNTQNRKEEEKEKALTEWeskkdstlVPSagtLVVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1426 PSTLAGHWQQELSTY--APFLKVSAYVGPpaERAKIRSKMKKSDVVVTSYDICRND---------VDELVKIDWNYCVLD 1494
Cdd:cd18072 81 PASLVHQWKNEVESRvaSNKLRVCLYHGP--NRERIGEVLRDYDIVITTYSLVAKEiptykeesrSSPLFRIAWARIILD 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 81170682 1495 EGHVIKNARAKLTKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFL 1540
Cdd:cd18072 159 EAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFL 204
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
1358-1593 |
4.77e-30 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 119.77 E-value: 4.77e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFlNKYELHG-ILCDDMGLGKTLQTICIVasdhynrQKLFEESgspkfAHVPSLIVCPSTLAGHWQQE 1436
Cdd:cd18060 1 LREYQLEGVNWLLF-NWYNRQNcILADEMGLGKTIQSIAFL-------QEVYNVG-----IHGPFLVIAPLSTITNWERE 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1437 LSTYAPfLKVSAYVGPPAERAKIR--------SKMK------KSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNA 1502
Cdd:cd18060 68 FNTWTE-MNTIVYHGSLASRQMIQqyemyckdSRGRlipgayKFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNR 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1503 RAKLTKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFvrpiaasRDAKSsskerERGTLALEAI 1582
Cdd:cd18060 147 NCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDF-------GDLKT-----EEQVQKLQAI 214
|
250
....*....|.
gi 81170682 1583 HKqvlPFMLRR 1593
Cdd:cd18060 215 LK---PMMLRR 222
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
1358-1593 |
9.81e-30 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 119.40 E-value: 9.81e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVASdhynrqkLFEESGSPKfahvPSLIVCPSTLAGHWQQEL 1437
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYS-------LYKEGHSKG----PFLVSAPLSTIINWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1438 STYAPFLKVSAYVGPPAERAKIR-----------------SKMKKS-----DVVVTSYDICRNDVDELVKIDWNYCVLDE 1495
Cdd:cd18056 70 EMWAPDMYVVTYVGDKDSRAIIRenefsfednairggkkaSRMKKEasvkfHVLLTSYELITIDMAILGSIDWACLIVDE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1496 GHVIKNARAKLTKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVrpiaasrdakSSSKERErg 1575
Cdd:cd18056 150 AHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFA----------DIAKEDQ-- 217
|
250
....*....|....*...
gi 81170682 1576 tlaLEAIHKQVLPFMLRR 1593
Cdd:cd18056 218 ---IKKLHDMLGPHMLRR 232
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
1358-1593 |
4.55e-29 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 117.42 E-value: 4.55e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVASdhynrqkLFEESGSPKfahvPSLIVCPSTLAGHWQQEL 1437
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYS-------LYKEGHTKG----PFLVSAPLSTIINWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1438 STYAPFLKVSAYVGPPAERAKIRS-----------------KMK-----KSDVVVTSYDICRNDVDELVKIDWNYCVLDE 1495
Cdd:cd18055 70 QMWAPDFYVVTYTGDKDSRAIIREnefsfddnavkggkkafKMKreaqvKFHVLLTSYELVTIDQAALGSIRWACLVVDE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1496 GHVIKNARAKLTKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVrpiaasrdakSSSKERErg 1575
Cdd:cd18055 150 AHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFA----------DISKEDQ-- 217
|
250
....*....|....*...
gi 81170682 1576 tlaLEAIHKQVLPFMLRR 1593
Cdd:cd18055 218 ---IKKLHDLLGPHMLRR 232
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
1358-1542 |
1.14e-28 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 117.06 E-value: 1.14e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAflnkyELHGILCDDMGLGKTLQTICIVAS---------DHYNRQKLFEESGSPKFAHVP-----SLI 1423
Cdd:cd18070 1 LLPYQRRAVNWML-----VPGGILADEMGLGKTVEVLALILLhprpdndldAADDDSDEMVCCPDCLVAETPvsskaTLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1424 VCPSTLAGHWQQELSTYAPF-LKVSAYVGPPAERAKIRSKMKK---SDVVVTSYDICRNDVDE----------------- 1482
Cdd:cd18070 76 VCPSAILAQWLDEINRHVPSsLKVLTYQGVKKDGALASPAPEIlaeYDIVVTTYDVLRTELHYaeanrsnrrrrrqkrye 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81170682 1483 -----LVKIDWNYCVLDEGHVIKNARAKLTKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMP 1542
Cdd:cd18070 156 appspLVLVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGV 220
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
1358-1593 |
2.02e-28 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 115.55 E-value: 2.02e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVASdhynrqkLFEESGSPKfahvPSLIVCPSTLAGHWQQEL 1437
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYS-------LYKEGHSKG----PYLVSAPLSTIINWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1438 STYAPFLKVSAYVGPPAERAKIRS-----------------KMKKS-----DVVVTSYDICRNDVDELVKIDWNYCVLDE 1495
Cdd:cd18057 70 EMWAPDFYVVTYTGDKESRSVIREnefsfednairsgkkvfRMKKEaqikfHVLLTSYELITIDQAILGSIEWACLVVDE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1496 GHVIKNARAKLTKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVrpiaasrdakSSSKERErg 1575
Cdd:cd18057 150 AHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFA----------DISKEDQ-- 217
|
250
....*....|....*...
gi 81170682 1576 tlaLEAIHKQVLPFMLRR 1593
Cdd:cd18057 218 ---IKKLHDLLGPHMLRR 232
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
1379-1571 |
5.38e-27 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 111.90 E-value: 5.38e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1379 GILCDDMGLGKTLQTICIVASDHYNRQKlfeesgsPKFAHVpsLIVCPSTLAGHWQQELSTYAPFLK---------VSAY 1449
Cdd:cd18068 31 CILAHCMGLGKTLQVVTFLHTVLLCEKL-------ENFSRV--LVVCPLNTVLNWLNEFEKWQEGLKdeekievneLATY 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1450 VGPPAERAKIRSKMKKSDVVVTSYDICRNDVDE----------------LVKIDWNYCVLDEGHVIKNARAKLTKAVKSL 1513
Cdd:cd18068 102 KRPQERSYKLQRWQEEGGVMIIGYDMYRILAQErnvksreklkeifnkaLVDPGPDFVVCDEGHILKNEASAVSKAMNSI 181
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 81170682 1514 RSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIAASRDAKSSSKE 1571
Cdd:cd18068 182 RTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQNGQCADSTLVD 239
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
1358-1549 |
1.24e-26 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 109.12 E-value: 1.24e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKyelHGILCDDMGLGKTLQtICIVASDHYNRQKlfeesgspkfaHVPSLIVCP-STLAGHWQQE 1436
Cdd:smart00487 9 LRPYQKEAIEALLSGLR---DVILAAPTGSGKTLA-ALLPALEALKRGK-----------GGRVLVLVPtRELAEQWAEE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1437 LSTYAPFL---KVSAYVGPPAERAKIRSKMKKSDVVVTSYDICRNDV--DELVKIDWNYCVLDEGHVIKNA--RAKLTKA 1509
Cdd:smart00487 74 LKKLGPSLglkVVGLYGGDSKREQLRKLESGKTDILVTTPGRLLDLLenDKLSLSNVDLVILDEAHRLLDGgfGDQLEKL 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 81170682 1510 VKSLR-SYHRLILSGTP---IQNNVLELWSLFDFLMPGFLGTEK 1549
Cdd:smart00487 154 LKLLPkNVQLLLLSATPpeeIENLLELFLNDPVFIDVGFTPLEP 197
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
1358-1593 |
2.12e-26 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 109.32 E-value: 2.12e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNWLAFLNKYELHGILCDDMGLGKTLQTICIVASDHYNRQKlfeesgspkfahVPSLIVCPSTLAGHWQQEL 1437
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIR------------GPFLIIAPLSTIANWEREF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1438 STYAPfLKVSAYVGPPAERAKIRS-KMKKSD-------------VVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNAR 1503
Cdd:cd18061 69 RTWTD-LNVVVYHGSLISRQMIQQyEMYFRDsqgriirgayrfqAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNKN 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1504 AKLTKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFvrpiaasRDAKSSSKERErgtlaLEAIH 1583
Cdd:cd18061 148 CKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEF-------GDLKTEEQVQK-----LQAIL 215
|
250
....*....|
gi 81170682 1584 KqvlPFMLRR 1593
Cdd:cd18061 216 K---PMMLRR 222
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
1380-1559 |
1.54e-24 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 104.13 E-value: 1.54e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1380 ILCDDMGLGKTLQTICIVasdhynrQKLFEESGSPKfahvpSLIVCPSTLAGHWQQELSTYAPFLKVSAYVGPP------ 1453
Cdd:cd18069 32 ILAHSMGLGKTLQVISFL-------DVLLRHTGAKT-----VLAIVPVNTLQNWLSEFNKWLPPPEALPNVRPRpfkvfi 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1454 --------AERAKIRSK-MKKSDVVVTSYDICRN-DVDELVkidwnycVLDEGHVIKNARAKLTKAVKSLRSYHRLILSG 1523
Cdd:cd18069 100 lndehkttAARAKVIEDwVKDGGVLLMGYEMFRLrPGPDVV-------ICDEGHRIKNCHASTSQALKNIRSRRRIVLTG 172
|
170 180 190
....*....|....*....|....*....|....*.
gi 81170682 1524 TPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPI 1559
Cdd:cd18069 173 YPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPI 208
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
1730-1836 |
1.24e-21 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 91.50 E-value: 1.24e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1730 LTNAVSEHRVLIFCQLKDMLDMvekDLLQATMpDVTYMRLDGSVEPTKRQEAVTKFNNDpSIDVLLlTTHVGGLGLNLTG 1809
Cdd:pfam00271 9 LLKKERGGKVLIFSQTKKTLEA---ELLLEKE-GIKVARLHGDLSQEEREEILEDFRKG-KIDVLV-ATDVAERGLDLPD 82
|
90 100
....*....|....*....|....*..
gi 81170682 1810 ADTVIFVEHDWNPMRDLQAMDRAHRIG 1836
Cdd:pfam00271 83 VDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
1358-1557 |
1.83e-17 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 83.11 E-value: 1.83e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVnwLAFLNKYELHGILCDDMGLGKTLQTICIVasdhynrqKLFEESGspkfAHVPSLIVCPSTLAGHWQQEL 1437
Cdd:cd18011 1 PLPHQIDAV--LRALRKPPVRLLLADEVGLGKTIEAGLII--------KELLLRG----DAKRVLILCPASLVEQWQDEL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1438 ST---YAPFLKVSAYVgpPAERAKIRSKMKKSDVVVTSYD-ICRND--VDELVKIDWNYCVLDEGHVIKNAR----AKLT 1507
Cdd:cd18011 67 QDkfgLPFLILDRETA--AQLRRLIGNPFEEFPIVIVSLDlLKRSEerRGLLLSEEWDLVVVDEAHKLRNSGggkeTKRY 144
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81170682 1508 KAVKSL--RSYHRLILSGTPIQNNVLELWSLFDFLMPGF----------LGTEKTFQERFVR 1557
Cdd:cd18011 145 KLGRLLakRARHVLLLTATPHNGKEEDFRALLSLLDPGRfavlgrflrlDGLREVLAKVLLR 206
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
1763-1836 |
3.35e-17 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 78.02 E-value: 3.35e-17
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81170682 1763 DVTYMRLDGSVEPTKRQEAVTKFNNDPSidVLLLTTHVGGLGLNLTGADTVIFVEHDWNPMRDLQAMDRAHRIG 1836
Cdd:smart00490 11 GIKVARLHGGLSQEEREEILDKFNNGKI--KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
1358-1564 |
3.77e-16 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 79.32 E-value: 3.77e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVNwlaFLNKYELHGILCDdMGLGKTLQTICIVasdhynrQKLFEESgspkfAHVPSLIVCPSTLAGH-WQQE 1436
Cdd:cd18013 1 PHPYQKVAIN---FIIEHPYCGLFLD-MGLGKTVTTLTAL-------SDLQLDD-----FTRRVLVIAPLRVARStWPDE 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1437 LSTYAPF--LKVSAYVGPPAERakIRSKMKKSDVVVTSYDICrNDVDELVKIDWNY--CVLDEGHVIKNARAKLTKAVKS 1512
Cdd:cd18013 65 VEKWNHLrnLTVSVAVGTERQR--SKAANTPADLYVINRENL-KWLVNKSGDPWPFdmVVIDELSSFKSPRSKRFKALRK 141
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 81170682 1513 LRSY-HRLI-LSGTPIQNNVLELWSLFDFLMPGflgtektfqERFVRPIAASRD 1564
Cdd:cd18013 142 VRPViKRLIgLTGTPSPNGLMDLWAQIALLDQG---------ERLGRSITAYRE 186
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
1358-1525 |
3.32e-08 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 58.50 E-value: 3.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1358 LRKYQQEGVN-WLAFLNKYELHGILCDDMGLGKTLqTICIVASDHYNRQKLfeesgspkfahvpsLIVCPST-LAGHWQQ 1435
Cdd:COG1061 81 LRPYQQEALEaLLAALERGGGRGLVVAPTGTGKTV-LALALAAELLRGKRV--------------LVLVPRReLLEQWAE 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1436 ELSTyapFLKVSAYVGPPAERAKirskmkksDVVVTSYD-ICRNDVDELVKIDWNYCVLDEGHvikNARAK-LTKAVKSL 1513
Cdd:COG1061 146 ELRR---FLGDPLAGGGKKDSDA--------PITVATYQsLARRAHLDELGDRFGLVIIDEAH---HAGAPsYRRILEAF 211
|
170
....*....|..
gi 81170682 1514 RSYHRLILSGTP 1525
Cdd:COG1061 212 PAAYRLGLTATP 223
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
1639-1917 |
3.10e-07 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 55.51 E-value: 3.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1639 ETEKTQGtrkkksqkahIFQALQYMRKLCNHPALILTEKHPKRnaIVKQ--------LAKENSGLHdlkhaPKLTALGQL 1710
Cdd:COG1111 281 ELLETQG----------VEALLRYLERLEEEARSSGGSKASKR--LVSDprfrkamrLAEEADIEH-----PKLSKLREI 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1711 LRdcglgnSSVNSNGIDsaltnavsehRVLIFCQLKDMLDMVEKDLLQATMPDVTYM------RLDGSVEpTKRQEAVTK 1784
Cdd:COG1111 344 LK------EQLGTNPDS----------RIIVFTQYRDTAEMIVEFLSEPGIKAGRFVgqaskeGDKGLTQ-KEQIEILER 406
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1785 FNNDpSIDVLLlTTHVGGLGLNLTGADTVIFVEHDWNPMRDLQAMDRAHRIGQKKVVnVyrLITRGCLEEKIMGLQRFKM 1864
Cdd:COG1111 407 FRAG-EFNVLV-ATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGRKREGRVV-V--LIAKGTRDEAYYWSSRRKE 481
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1865 NVASTVVNQQNAGLSSIGTDQI-------LDLFNTTADEQQTVQNIDKEESEDAAGRGLS 1917
Cdd:COG1111 482 KKMKSILKKLKKLLDKQEKEKLkesaqatLDEFESIKELAEDEINEKDLDEIESSENGAH 541
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
1378-1524 |
3.93e-04 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 42.78 E-value: 3.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1378 HGILCDDMGLGKTLqTICIVASDHYNRQKLFeesgspkfahvpSLIVCP-STLAGHWQQELSTYA-PFLKVSAYVGppAE 1455
Cdd:cd00046 3 NVLITAPTGSGKTL-AALLAALLLLLKKGKK------------VLVLVPtKALALQTAERLRELFgPGIRVAVLVG--GS 67
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81170682 1456 RAKIRSKMK--KSDVVVTSYDICRNDVDELVKI---DWNYCVLDEGHVI-KNARAKLTKA---VKSLRSYHRLI-LSGT 1524
Cdd:cd00046 68 SAEEREKNKlgDADIIIATPDMLLNLLLREDRLflkDLKLIIVDEAHALlIDSRGALILDlavRKAGLKNAQVIlLSAT 146
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
1794-1841 |
1.41e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 39.22 E-value: 1.41e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 81170682 1794 LLLTTHVGGLGLNLTGADTVIFVEHDWNPMRDLQAMDRAHRIGQKKVV 1841
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGE 72
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
1730-1841 |
7.54e-03 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 38.88 E-value: 7.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170682 1730 LTNAVSEHRVLIFCQLKD-MLDMVEkdLLQATMPDVTYMRLDG--SVEPTK------RQEAVTKFNNDpSIDVLLLTThV 1800
Cdd:cd18801 24 KKQEGSDTRVIIFSEFRDsAEEIVN--FLSKIRPGIRATRFIGqaSGKSSKgmsqkeQKEVIEQFRKG-GYNVLVATS-I 99
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 81170682 1801 GGLGLNLTGADTVIFVEHDWNPMRDLQAMDRAHRIGQKKVV 1841
Cdd:cd18801 100 GEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGRKRQGRVV 140
|
|
| |
