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Conserved domains on  [gi|21542118|sp|O75473|]
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RecName: Full=Leucine-rich repeat-containing G-protein coupled receptor 5; AltName: Full=G-protein coupled receptor 49; AltName: Full=G-protein coupled receptor 67; AltName: Full=G-protein coupled receptor HG38; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
 558-831 2.81e-172

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


:

Pssm-ID: 320485  Cd Length: 274  Bit Score: 500.53  E-value: 2.81e-172
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 558 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 637
Cdd:cd15363   1 WLIRIGVWTIAVLALVCNALVTATVFRSPLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVGC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 638 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPF 717
Cdd:cd15363  81 QITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPLPF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 718 GEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 797
Cdd:cd15363 161 GEPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLTFIS 240

                       250       260       270
                ....*....|....*....|....*....|....
gi 21542118 798 PEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 831
Cdd:cd15363 241 PEVIKFILLVIVPLPACLNPLLYILFNPHFKEDL 274
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-477 3.87e-32

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.05  E-value: 3.87e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  92 LEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDD 171
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 172 NALTEIPVQAFRSLSALQAMTLALNKihhipdyAFGNLSSLVVLHLHNNRIHSLGKkCFDGLHSLETLDLNYNNLDEFPT 251
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 252 AIRTLSNLKELGFHSNNIRSIPEkAFVGNPSLITIHFYDNPIQFVGrSAFQHLPELRTLTLNGaSQITEFPD-LTGTANL 330
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSG-NQLTDLPEpLANLTNL 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 331 ESLTLTGAQISSLPQTvcNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKI 410
Cdd:COG4886 231 ETLDLSNNQLTDLPEL--GNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21542118 411 AIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAY 477
Cdd:COG4886 309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLL 375
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-65 4.85e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 4.85e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 21542118    33 GCPTHCHCEPdgrmlLRVDCSDLGLSELPSNLS 65
Cdd:pfam01462   1 ACPVPCHCSA-----TVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
 558-831 2.81e-172

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 500.53  E-value: 2.81e-172
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 558 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 637
Cdd:cd15363   1 WLIRIGVWTIAVLALVCNALVTATVFRSPLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVGC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 638 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPF 717
Cdd:cd15363  81 QITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPLPF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 718 GEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 797
Cdd:cd15363 161 GEPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLTFIS 240

                       250       260       270
                ....*....|....*....|....*....|....
gi 21542118 798 PEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 831
Cdd:cd15363 241 PEVIKFILLVIVPLPACLNPLLYILFNPHFKEDL 274
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-477 3.87e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.05  E-value: 3.87e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  92 LEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDD 171
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 172 NALTEIPVQAFRSLSALQAMTLALNKihhipdyAFGNLSSLVVLHLHNNRIHSLGKkCFDGLHSLETLDLNYNNLDEFPT 251
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 252 AIRTLSNLKELGFHSNNIRSIPEkAFVGNPSLITIHFYDNPIQFVGrSAFQHLPELRTLTLNGaSQITEFPD-LTGTANL 330
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSG-NQLTDLPEpLANLTNL 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 331 ESLTLTGAQISSLPQTvcNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKI 410
Cdd:COG4886 231 ETLDLSNNQLTDLPEL--GNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21542118 411 AIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAY 477
Cdd:COG4886 309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLL 375
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 71-426 5.16e-21

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 99.15  E-value: 5.16e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLR-HVPTEaLQNLRSLQSLRLDANH 149
Cdd:PLN00113 145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRE-LGQMKSLKWIYLGYNN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  150 ISYVPPSCFSGLHSLRHLWLDDNALT-EIPVqAFRSLSALQAMTLALNKIH-HIPDYAFG-------------------- 207
Cdd:PLN00113 224 LSGEIPYEIGGLTSLNHLDLVYNNLTgPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIFSlqklisldlsdnslsgeipe 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  208 ---NLSSLVVLHLHNN----------------RIHSLGKKCFDG--------LHSLETLDLNYNNL-------------- 246
Cdd:PLN00113 303 lviQLQNLEILHLFSNnftgkipvaltslprlQVLQLWSNKFSGeipknlgkHNNLTVLDLSTNNLtgeipeglcssgnl 382

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  247 -----------DEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGA 315
Cdd:PLN00113 383 fklilfsnsleGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARN 462

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  316 SQITEFPDLTGTANLESLTLTGAQIS-SLPQTVCNqLPNLQVLDLSYNLLE-DLPS-FSVCQKLQKIDLRHNEIYEIKVD 392
Cdd:PLN00113 463 KFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGS-LSELMQLKLSENKLSgEIPDeLSSCKKLVSLDLSHNQLSGQIPA 541

                        410       420       430
                 ....*....|....*....|....*....|....
gi 21542118  393 TFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIK 426
Cdd:PLN00113 542 SFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQ 575
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 161-386 6.84e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 71.74  E-value: 6.84e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 161 LHSLRHLWLDDNALTEIPvqAFRSLSALQAMTLALNKIHHIPDyaFGNLSSLVVLHLHNNRIHSLGKkcFDGLHSLETLD 240
Cdd:cd21340   1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 241 LNYNNldefptaIRTLSNLKELgfhsnnirsipekafvgnPSLITIHFyDNpiqfvgrsafQHLPELRTLTLNGASqite 320
Cdd:cd21340  75 LGGNR-------ISVVEGLENL------------------TNLEELHI-EN----------QRLPPGEKLTFDPRS---- 114

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21542118 321 fpdLTGTAN-LESLTLTGAQISSLPQTVCnqLPNLQVLDLSYNLLEDL----PSFSVCQKLQKIDLRHNEI 386
Cdd:cd21340 115 ---LAALSNsLRVLNISGNNIDSLEPLAP--LRNLEQLDASNNQISDLeellDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
188-246 6.16e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 6.16e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 21542118   188 LQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL 246
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 575-820 3.43e-05

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 46.52  E-value: 3.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   575 NALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSfarhgawWENG-VGCHVIGFLSIFASESSVF 653
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGD-------WPFGsALCKIVGALFVVNGYASIL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   654 LLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGA----SPLCLP-LPFGEPSTMGYMVA 728
Cdd:pfam00001  75 LLTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVpegnVTVCFIdFPEDLSKPVSYTLL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   729 LILLNSLC-FLMMTIAYTKLYC------NLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVI 801
Cdd:pfam00001 155 ISVLGFLLpLLVILVCYTLIIRtlrksaSKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLL 234

                         250       260
                  ....*....|....*....|..
gi 21542118   802 KFILLVVVPLP---ACLNPLLY 820
Cdd:pfam00001 235 DKALSVTLWLAyvnSCLNPIIY 256
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-65 4.85e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 4.85e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 21542118    33 GCPTHCHCEPdgrmlLRVDCSDLGLSELPSNLS 65
Cdd:pfam01462   1 ACPVPCHCSA-----TVVNCSDRGLTAVPRDLP 28
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-70 5.54e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.07  E-value: 5.54e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 21542118     33 GCPTHCHCEPdgrmlLRVDCSDLGLSELPSNLSVFTSY 70
Cdd:smart00013   1 ACPAPCNCSG-----TAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
 558-831 2.81e-172

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 500.53  E-value: 2.81e-172
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 558 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 637
Cdd:cd15363   1 WLIRIGVWTIAVLALVCNALVTATVFRSPLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVGC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 638 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPF 717
Cdd:cd15363  81 QITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPLPF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 718 GEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 797
Cdd:cd15363 161 GEPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLTFIS 240

                       250       260       270
                ....*....|....*....|....*....|....
gi 21542118 798 PEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 831
Cdd:cd15363 241 PEVIKFILLVIVPLPACLNPLLYILFNPHFKEDL 274
7tmA_LRR_GPR cd15138
orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A ...
 558-831 4.05e-155

orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), 5 (LGR5), and 6 (LGR6). These receptors contain a subfamily of receptors related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The RSPO proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320266  Cd Length: 274  Bit Score: 456.24  E-value: 4.05e-155
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 558 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 637
Cdd:cd15138   1 WMIRLTVWFIFLLALFCNLLVILTVFASCTSLPPSKLFIGLIAVSNLLTGISTGILAFVDAVTFGRFAEFGAWWETGSGC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 638 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPF 717
Cdd:cd15138  81 KVAGFLAVFSSESSVFLLTLAAVERSLSVKDIMKNGKSNHLKSFRVAALLCFLLATVAAAFPLFHRGEYGASPLCLPFPT 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 718 GEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 797
Cdd:cd15138 161 GEPPSLGFTVALVLLNSLCFLLMAVAYTKLYCNLEKGDLEENWDCSMVKHVAWLIFTNCILFCPVAFLSFASLITLISIS 240

                       250       260       270
                ....*....|....*....|....*....|....
gi 21542118 798 PEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 831
Cdd:cd15138 241 PEIMKSVLLVVFPLPACLNPLLYVLFNPHFKEDL 274
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 558-831 6.10e-116

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 354.87  E-value: 6.10e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 558 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 637
Cdd:cd15362   1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGYLSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLGC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 638 HVIGFLSIFASESSVFLLTLAALERGFSVKySAKFETKAP-FSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLP-- 714
Cdd:cd15362  81 RATGFLSVFASEASILLLTLAAVQCSVSVS-CVRAYGKSPsLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPsp 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 715 LPFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLT 794
Cdd:cd15362 160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 21542118 795 FISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 831
Cdd:cd15362 240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 276
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
 558-830 2.93e-85

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320483  Cd Length: 274  Bit Score: 274.05  E-value: 2.93e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 558 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 637
Cdd:cd15361   1 WMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSGC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 638 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPF 717
Cdd:cd15361  81 KVAGFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQFQIAALLAFLVATAAGCLPLFHGGEYSASPLCLPFPT 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 718 GEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 797
Cdd:cd15361 161 GETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISIS 240

                       250       260       270
                ....*....|....*....|....*....|...
gi 21542118 798 PEVIKFILLVVVPLPACLNPLLYILFNPHFKED 830
Cdd:cd15361 241 PEIMKSVTLIFFPLPACLNPVLYVFFNPKFKED 273
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
 558-831 1.02e-81

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 265.26  E-value: 1.02e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 558 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPI-KLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVG 636
Cdd:cd14980   1 ISLRIFIWIIGILALIGNILVIIWHISSKKKKKKVpKLLIINLAIADFLMGIYLLIIAIADQYYRGRYAQYSEEWLRSPP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 637 CHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFEtKAPFSSLKVIILLCALLALTMAAVPLLGGSK-------YGAS 709
Cdd:cd14980  81 CLLACFLVSLSSLMSVLMMLLITLDRYICIVYPFSNK-RLSYKSAKIILILGWLFSIIFAAIPILYSINqpgdnrlYGYS 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 710 PLCLPLPFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKG-----DLENIWDCSMVKHIALLLFTNCILNCPVAF 784
Cdd:cd14980 160 SICMPSNVSNPYYRGWLIAYLLLTFIAWIIICILYILIFISVRKSrksarRSSSKRDKRIAIRLALILITDLICWLPYYI 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 21542118 785 LSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 831
Cdd:cd14980 240 VIFSGLLTSTEIDIHVLQFIAILALPLNSAINPYLYTLTTPTFKRDF 286
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
 558-831 6.54e-50

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 177.41  E-value: 6.54e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 558 WLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 637
Cdd:cd15136   1 WWLRIGVWFVFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIYLGLLAIVDAKTLGEYYNYAIDWQTGAGC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 638 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPF 717
Cdd:cd15136  81 KTAGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYSKTSICLPFET 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 718 GEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLdkGDLENIW---DCSMVKHIALLLFTNCILNCPVAFLSFSSLINLT 794
Cdd:cd15136 161 ETPVSKAYVIFLLLFNGLAFLIICGCYIKIYLSV--RGSGRAAnsnDTRIAKRMALLVFTDFLCWAPIAFFGLTAAFGLP 238

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 21542118 795 FISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 831
Cdd:cd15136 239 LISVSNAKILLVFFYPLNSCANPFLYAIFTKQFRRDC 275
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
 559-831 2.38e-36

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 138.50  E-value: 2.38e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 559 LIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCH 638
Cdd:cd15964   2 FLRIVVWFVNLLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFCMGIYLLLIASVDLHTRSEYYNHAIDWQTGPGCN 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 639 VIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFG 718
Cdd:cd15964  82 TAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSYAKVSICLPMDTE 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 719 EPSTMGYMVALILLNSLCFLMMTIAYTKLYCNL-----DKGDLeniwDCSMVKHIALLLFTNCILNCPVAFLSFSSLINL 793
Cdd:cd15964 162 TPLAQAYIVFVLMLNIIAFVIICACYIKIYITVrnpqyKSGDK----DTKIAKRMAVLIFTDFICMAPISFYALSAILNK 237

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 21542118 794 TFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 831
Cdd:cd15964 238 PLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFRRDV 275
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
 559-831 2.71e-34

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 132.67  E-value: 2.71e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 559 LIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCH 638
Cdd:cd15360   2 ILRVLIWFINILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIDWQTGAGCA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 639 VIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFG 718
Cdd:cd15360  82 AAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMDIE 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 719 EPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGD-LENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 797
Cdd:cd15360 162 SPLSQAYIIFILVLNVLAFLIICACYIKIYLTVRNPNfVSSNSDTKIAKRMAVLIFTDFLCMAPISFFAISASLKVPLIT 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 21542118 798 PEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 831
Cdd:cd15360 242 VSKSKILLVLFYPINSCANPFLYAIFTKTFRRDF 275
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
 559-831 1.45e-33

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 130.75  E-value: 1.45e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 559 LIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCH 638
Cdd:cd15359   2 FLRVLIWFINILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIDWQTGSGCS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 639 VIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFG 718
Cdd:cd15359  82 TAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNYMKVSICLPMDIE 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 719 EPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENI-WDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFIS 797
Cdd:cd15359 162 TLLSQAYILLILVLNVIAFLVICACYIKIYLAVQNPELVAKnKDTKIAKRMAILIFTDFTCMAPISFFAISAAFKVPLIT 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 21542118 798 PEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 831
Cdd:cd15359 242 VTNSKILLVLFYPINSCANPFLYAIFTKAFRRDF 275
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-477 3.87e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.05  E-value: 3.87e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  92 LEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDD 171
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 172 NALTEIPVQAFRSLSALQAMTLALNKihhipdyAFGNLSSLVVLHLHNNRIHSLGKkCFDGLHSLETLDLNYNNLDEFPT 251
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 252 AIRTLSNLKELGFHSNNIRSIPEkAFVGNPSLITIHFYDNPIQFVGrSAFQHLPELRTLTLNGaSQITEFPD-LTGTANL 330
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSG-NQLTDLPEpLANLTNL 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 331 ESLTLTGAQISSLPQTvcNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKI 410
Cdd:COG4886 231 ETLDLSNNQLTDLPEL--GNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21542118 411 AIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAY 477
Cdd:COG4886 309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLL 375
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-425 4.58e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 126.97  E-value: 4.58e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  47 LLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNql 126
Cdd:COG4886  29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-- 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 127 rhvptEALQNLRSLQSLRLDANHISYVPPScFSGLHSLRHLWLDDNALTEIPVqAFRSLSALQAMTLALNKIHHIPDyAF 206
Cdd:COG4886 107 -----EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-EL 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 207 GNLSSLVVLHLHNNRIHSLGKKcFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEkafvgnpsliti 286
Cdd:COG4886 179 GNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE------------ 245

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 287 hfydnpiqfvgrsaFQHLPELRTLTLNGaSQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLED 366
Cdd:COG4886 246 --------------LGNLTNLEELDLSN-NQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL 310

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21542118 367 LPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLI 425
Cdd:COG4886 311 LELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
 559-829 9.63e-31

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 122.69  E-value: 9.63e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 559 LIRIGVWTIAVLALTCNALVTstVFRSPLYISPI--KLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVG 636
Cdd:cd15137   2 VLRVFIWVVGIIALLGNLFVL--IWRLKYKEENKvhSFLIKNLAIADFLMGVYLLIIASVDLYYRGVYIKHDEEWRSSWL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 637 CHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFeTKAPFSSLKVIILLCALLALTMAAVPLLG----GSKYGASPLC 712
Cdd:cd15137  80 CTFAGFLATLSSEVSVLILTLITLDRFICIVFPFSG-RRLGLRRAIIVLACIWLIGLLLAVLPLLPwdyfGNFYGRSGVC 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 713 LPLPFGEPSTMG--YMVALIL-LNSLCFLMMTIAYTKLYCNLDK-----GDLENIWDCSMVKHIALLLFTNCILNCPVAF 784
Cdd:cd15137 159 LPLHITDERPAGweYSVFVFLgLNFLAFVFILLSYIAMFISIRRtrkaaASRKSKRDMAVAKRFFLIVLTDFLCWIPIIV 238

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 21542118 785 LSFSSLINLTfISPEVIKFILLVVVPLPACLNPLLYILFNPHFKE 829
Cdd:cd15137 239 IGILALSGVP-IPGEVYAWVAVFVLPINSALNPILYTLSTPKFRK 282
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-335 3.62e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.11  E-value: 3.62e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  47 LLRVDCSDLGLSELPSNLSVFTS--YLDLSMNNISQLlPNPLPSLRFLEELRLAGNALTYIPKgAFTGLYSLKVLMLQNN 124
Cdd:COG4886 115 LESLDLSGNQLTDLPEELANLTNlkELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNN 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 125 QLRHVPtEALQNLRSLQSLRLDANHISYVPPScFSGLHSLRHLWLDDNALTEIPvqAFRSLSALQAMTLALNKIHHIPDy 204
Cdd:COG4886 193 QITDLP-EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP- 267

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 205 aFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLI 284
Cdd:COG4886 268 -LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 21542118 285 TIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTL 335
Cdd:COG4886 347 LALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 71-426 5.16e-21

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 99.15  E-value: 5.16e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLR-HVPTEaLQNLRSLQSLRLDANH 149
Cdd:PLN00113 145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRE-LGQMKSLKWIYLGYNN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  150 ISYVPPSCFSGLHSLRHLWLDDNALT-EIPVqAFRSLSALQAMTLALNKIH-HIPDYAFG-------------------- 207
Cdd:PLN00113 224 LSGEIPYEIGGLTSLNHLDLVYNNLTgPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIFSlqklisldlsdnslsgeipe 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  208 ---NLSSLVVLHLHNN----------------RIHSLGKKCFDG--------LHSLETLDLNYNNL-------------- 246
Cdd:PLN00113 303 lviQLQNLEILHLFSNnftgkipvaltslprlQVLQLWSNKFSGeipknlgkHNNLTVLDLSTNNLtgeipeglcssgnl 382

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  247 -----------DEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGA 315
Cdd:PLN00113 383 fklilfsnsleGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARN 462

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  316 SQITEFPDLTGTANLESLTLTGAQIS-SLPQTVCNqLPNLQVLDLSYNLLE-DLPS-FSVCQKLQKIDLRHNEIYEIKVD 392
Cdd:PLN00113 463 KFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGS-LSELMQLKLSENKLSgEIPDeLSSCKKLVSLDLSHNQLSGQIPA 541

                        410       420       430
                 ....*....|....*....|....*....|....
gi 21542118  393 TFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIK 426
Cdd:PLN00113 542 SFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQ 575
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 62-384 6.68e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 89.14  E-value: 6.68e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   62 SNLSVFTSyLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTY-IPKGAFTGLYSLKVLMLQNNQLR-HVPTEALQNlrs 139
Cdd:PLN00113  66 NNSSRVVS-IDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPN--- 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  140 LQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALT-EIPVqAFRSLSALQAMTLALNK-IHHIPdYAFGNLSSLVVLHL 217
Cdd:PLN00113 142 LETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVgKIPN-SLTNLTSLEFLTLASNQlVGQIP-RELGQMKSLKWIYL 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  218 HNNRIHSLGKKCFDGLHSLETLDLNYNNLD-EFPTAIRTLSNLKELGFHSNNIR-SIPEKAFvGNPSLITIHFYDNPI-- 293
Cdd:PLN00113 220 GYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLsg 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  294 --------------------QFVGR--SAFQHLPELRTLTLNGASQITEFP-DLTGTANLESLTLTGAQISS-LPQTVCN 349
Cdd:PLN00113 299 eipelviqlqnleilhlfsnNFTGKipVALTSLPRLQVLQLWSNKFSGEIPkNLGKHNNLTVLDLSTNNLTGeIPEGLCS 378

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 21542118  350 QlPNLQVLDLSYNLLEDL--PSFSVCQKLQKIDLRHN 384
Cdd:PLN00113 379 S-GNLFKLILFSNSLEGEipKSLGACRSLRRVRLQDN 414
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 567-824 2.37e-16

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 80.41  E-value: 2.37e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 567 IAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTfgsfarhGAWWENGVGCHVIGFLSIF 646
Cdd:cd00637   8 IFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLL-------GRWWFGDALCKLLGFLQSV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 647 ASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKY--GASPLCLPLPFGEPSTMG 724
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYdyGGYCCCCLCWPDLTLSKA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 725 YMVALILLN-SLCFLMMTIAYTKLYCNL-------------DKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSF-SS 789
Cdd:cd00637 161 YTIFLFVLLfLLPLLVIIVCYVRIFRKLrrhrrrirssssnSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLlDV 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 21542118 790 LINLTFISPEVIKFILLVVVPLPACLNPLLYILFN 824
Cdd:cd00637 241 FGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
 559-831 1.09e-15

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 78.67  E-value: 1.09e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 559 LIRIGVWTIAVLALTCNALVTS--TVFRSPLYISpiKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVG 636
Cdd:cd15966   2 ILRVFVWVMAFITCFGNLFVIGmrSFIRAENKTH--AMCIKILCCADCLMGVYLFFVGIFDVKYRGEYNKYALLWMESLQ 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 637 CHVIGFLSIFASESSVFLLTLAALERGFSVKYsakfetkaPFSSLK-------VIILLCALLALTMAAVPLLG----GSK 705
Cdd:cd15966  80 CRIIGFLAMLSTEVSVLLLTYLTLEKYLVIVF--------PFSNIRpgkcqtlIILISIWLVGFIIAVIPFWNedffGNY 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 706 YGASPLCLPLPFG---EPSTMGYMVALIL-LNSLCFLMMTIAYTKLYCNLDKGDLENI-------WDCSMVKHIALLLFT 774
Cdd:cd15966 152 YGKNGVCFPLHSDqteKIGAKGYSTGIFLgLNLLAFIIIVFSYSSMFCSIQKTGLQTTevrshihRDVAVANRFFFIVFS 231

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 21542118 775 NCILNCPVAFLSFSSLINLTfISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 831
Cdd:cd15966 232 DAICWIPIFLLKILSLFQVE-IPGTITSWIVIFILPINSALNPILYTLTTSFFKEKL 287
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
94-399 2.33e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.43  E-value: 2.33e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   94 ELRLAGNALT----YIPKGAFTglyslkvLMLQNNQLRHVPtealQNLRSlqslrldanhisyvppscfsglhSLRHLWL 169
Cdd:PRK15370 182 ELRLKILGLTtipaCIPEQITT-------LILDNNELKSLP----ENLQG-----------------------NIKTLYA 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  170 DDNALTEIPvqafRSL-SALQAMTLALNKIHHIPDYAFGNLSSLVVLHlhnNRIHSLGKKCFDGlhsLETLDLNYNNLDE 248
Cdd:PRK15370 228 NSNQLTSIP----ATLpDTIQEMELSINRITELPERLPSALQSLDLFH---NKISCLPENLPEE---LRYLSVYDNSIRT 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  249 FPTAIRtlSNLKELGFHSNNIRSIPEKAfvgNPSLITIHFYDNPIQFVGRSAfqhLPELRTLTLNGaSQITEFPDlTGTA 328
Cdd:PRK15370 298 LPAHLP--SGITHLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPASL---PPELQVLDVSK-NQITVLPE-TLPP 367

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21542118  329 NLESLTLTGAQISSLPQtvcnQLP-NLQVLDLSYNLL----EDLPSF-SVCQKLQKIDLRHNEIYEIKVDTFQQLLS 399
Cdd:PRK15370 368 TITTLDVSRNALTNLPE----NLPaALQIMQASRNNLvrlpESLPHFrGEGPQPTRIIVEYNPFSERTIQNMQRLMS 440
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 161-386 6.84e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 71.74  E-value: 6.84e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 161 LHSLRHLWLDDNALTEIPvqAFRSLSALQAMTLALNKIHHIPDyaFGNLSSLVVLHLHNNRIHSLGKkcFDGLHSLETLD 240
Cdd:cd21340   1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 241 LNYNNldefptaIRTLSNLKELgfhsnnirsipekafvgnPSLITIHFyDNpiqfvgrsafQHLPELRTLTLNGASqite 320
Cdd:cd21340  75 LGGNR-------ISVVEGLENL------------------TNLEELHI-EN----------QRLPPGEKLTFDPRS---- 114

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21542118 321 fpdLTGTAN-LESLTLTGAQISSLPQTVCnqLPNLQVLDLSYNLLEDL----PSFSVCQKLQKIDLRHNEI 386
Cdd:cd21340 115 ---LAALSNsLRVLNISGNNIDSLEPLAP--LRNLEQLDASNNQISDLeellDLLSSWPSLRELDLTGNPV 180
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 73-267 1.24e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.97  E-value: 1.24e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  73 LSMN--NISQLlpNPLPSLRFLEELRLAGNALTYIPKgaFTGLYSLKVLMLQNNQLRHVptEALQNLRSLQSLRLDANHI 150
Cdd:cd21340   7 LYLNdkNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 151 SYVppSCFSGLHSLRHLWLDDNALTEIPVQAF--RSLSALQAmtlalnkihhipdyafgnlsSLVVLHLHNNRIHSLgkK 228
Cdd:cd21340  81 SVV--EGLENLTNLEELHIENQRLPPGEKLTFdpRSLAALSN--------------------SLRVLNISGNNIDSL--E 136

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 21542118 229 CFDGLHSLETLDLNYNNLDEFP---TAIRTLSNLKELGFHSN 267
Cdd:cd21340 137 PLAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
 559-829 1.64e-12

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 69.13  E-value: 1.64e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 559 LIRIGVWtiAVLALTCNALVTSTVFRSplYISPIKLL----IGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENG 634
Cdd:cd15965   2 VQRVFVW--VVSAVTCFGNIFVICMRP--YIRSENKLhamsIISLCCADCLMGIYLFVIGAFDLKYRGEYNKHAQLWMDS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 635 VGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIIlLCALLALTMAAVPLLGG----SKYGASP 710
Cdd:cd15965  78 TQCQLVGSLAILSTEVSVLLLTYLTLEKYICIVYPFRCLTPGKCRTITILI-LIWIIGFIIAFIPLSNKeffrNYYGTNG 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 711 LCLPLPFGEPSTMG---YMVALIL-LNSLCFLMMTIAYTKLYCNLDKGDLENIW-------DCSMVKHIALLLFTNCILN 779
Cdd:cd15965 157 VCFPLHSEQPESTGaqiYSVVIFLgLNLAAFIIIVFSYGSMFYSIHQTAIMATEisnhikkEMTLAKRFFFIVFTDALCW 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 21542118 780 CPVAFLSFSSLINLTfISPEVIKFILLVVVPLPACLNPLLYILFNPHFKE 829
Cdd:cd15965 237 IPIFILKLLSLLQVE-IPGTISSWVVIFILPINSALNPILYTLTTRPFKE 285
LRR_8 pfam13855
Leucine rich repeat;
188-246 6.16e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 6.16e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 21542118   188 LQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL 246
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
92-150 6.99e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 6.99e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 21542118    92 LEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHI 150
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 131-386 7.95e-10

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 61.22  E-value: 7.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 131 TEALQNLRSLQSLRLDAN-----HISYVPPScfsgLH---SLRHLWLDDNALTEIPV------QAFRSLSALQAMTLALN 196
Cdd:cd00116  16 TELLPKLLCLQVLRLEGNtlgeeAAKALASA----LRpqpSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDN 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 197 KIHhiPD-----YAFGNLSSLVVLHLHNNRIHSLG-KKCFDGL----HSLETLDLNYNNLdefptairTLSNLKELGfhs 266
Cdd:cd00116  92 ALG--PDgcgvlESLLRSSSLQELKLNNNGLGDRGlRLLAKGLkdlpPALEKLVLGRNRL--------EGASCEALA--- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 267 nnirsipeKAFVGNPSLITIHFYDNPIQFVG----RSAFQHLPELRTLTLN-------GASQITE-FPDLtgtANLESLT 334
Cdd:cd00116 159 --------KALRANRDLKELNLANNGIGDAGiralAEGLKANCNLEVLDLNnngltdeGASALAEtLASL---KSLEVLN 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21542118 335 LTGAQISSLP-QTVCNQLPN----LQVLDLSYNLLEDLPSFSVCQ------KLQKIDLRHNEI 386
Cdd:cd00116 228 LGDNNLTDAGaAALASALLSpnisLLTLSLSCNDITDDGAKDLAEvlaekeSLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
115-174 1.03e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 1.03e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   115 SLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNAL 174
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
163-222 1.44e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 1.44e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   163 SLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRI 222
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
210-269 5.90e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 5.90e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21542118   210 SSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHSNNI 269
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
138-198 1.42e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 1.42e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21542118   138 RSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKI 198
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
352-410 3.79e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.79e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21542118   352 PNLQVLDLSYNLLEDLP--SFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKI 410
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
257-314 4.39e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 4.39e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 21542118   257 SNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNG 314
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
LRR_8 pfam13855
Leucine rich repeat;
374-454 1.54e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   374 QKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFStlpslikldlssnllssfpitGLHGLTHLKLTGN 453
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS---------------------GLPSLRYLDLSGN 59


                  .
gi 21542118   454 H 454
Cdd:pfam13855  60 R 60
LRR_8 pfam13855
Leucine rich repeat;
329-386 1.41e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.41e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   329 NLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLP--SFSVCQKLQKIDLRHNEI 386
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
57-203 2.48e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.24  E-value: 2.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   57 LSELPSNLSVFTSYLDLSMNNISqLLPNPLP-SLRFLEELRlagNALTYIPKGAFTGLYSLKVlmlQNNQLRHVPTEALQ 135
Cdd:PRK15370 253 ITELPERLPSALQSLDLFHNKIS-CLPENLPeELRYLSVYD---NSIRTLPAHLPSGITHLNV---QSNSLTALPETLPP 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  136 NLR------------------SLQSLRLDANHISYVPPSCFSglhSLRHLWLDDNALTEIPvqafRSL-SALQAMTLALN 196
Cdd:PRK15370 326 GLKtleagenaltslpaslppELQVLDVSKNQITVLPETLPP---TITTLDVSRNALTNLP----ENLpAALQIMQASRN 398


                 ....*..
gi 21542118  197 KIHHIPD 203
Cdd:PRK15370 399 NLVRLPE 405
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 52-269 3.40e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 3.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  52 CSDLGlSELPSNLSvfTSYLDLSMNN------ISQLLPNPLPSLRFLEELRLAGNALTYIPKG---AFTGLYSLKVLMLQ 122
Cdd:cd00116  40 AKALA-SALRPQPS--LKELCLSLNEtgriprGLQSLLQGLTKGCGLQELDLSDNALGPDGCGvleSLLRSSSLQELKLN 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 123 NNQL--RHVPTEAlqnlRSLQSLRldanhisyvppscfsglHSLRHLWLDDNALTEIPVQA----FRSLSALQAMTLALN 196
Cdd:cd00116 117 NNGLgdRGLRLLA----KGLKDLP-----------------PALEKLVLGRNRLEGASCEAlakaLRANRDLKELNLANN 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 197 KIHH--IPDYA--FGNLSSLVVLHLHNNRIHSLGKK----CFDGLHSLETLDLNYNNLDEFPTA------IRTLSNLKEL 262
Cdd:cd00116 176 GIGDagIRALAegLKANCNLEVLDLNNNGLTDEGASalaeTLASLKSLEVLNLGDNNLTDAGAAalasalLSPNISLLTL 255


                ....*..
gi 21542118 263 GFHSNNI 269
Cdd:cd00116 256 SLSCNDI 262
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
 566-828 3.74e-06

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 49.74  E-value: 3.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 566 TIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMltgvssavlaGVDAFTF---GSFARHGAWWENGVGCHVIGF 642
Cdd:cd15073   9 VAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDL----------GVSIIGYpfsAASDLHGSWKFGYAGCQWYAF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 643 LSIFASESSVFLLTLAALERgFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASP---LC-LPLPFG 718
Cdd:cd15073  79 LNIFFGMASIGLLTVVAVDR-YLTICRPDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPtgaTCtINWRKN 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 719 EPSTMGYMVALILLN-SLCFLMMTIAYTKLYCNLDKGDLENIW-----DCSMVKHIALLLFTnCILNCPVAFLSFSSLIN 792
Cdd:cd15073 158 DSSFVSYTMSVIVVNfIVPLAVMFYCYYNVSRFVKKVLASDCLesvniDWTDQNDVTKMSVI-MIVMFLVAWSPYSIVCL 236

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 21542118 793 LT-FISPEVIKFILLVVVPLPA----CLNPLLYILFNPHFK 828
Cdd:cd15073 237 WAsFGEPKKIPPWMAIIPPLFAksstFYNPCIYVIANKKFR 277
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
 566-829 4.14e-06

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 49.51  E-value: 4.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 566 TIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLtgvsSAVLAGVdaFTFGSFARHgaWWENG-VGCHVIGFLS 644
Cdd:cd14969   9 LIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLL----MSVVGYP--LSFYSNLSG--RWSFGdPGCVIYGFAV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 645 IFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIIlLCALLALTMAAVPLLGGSKYGASPL---CLP-LPFGEP 720
Cdd:cd14969  81 TFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRALILIA-FIWLYGLFWALPPLFGWSSYVPEGGgtsCSVdWYSKDP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 721 STMGYMVALILlnsLCFLM----MTIAYTKLYC-----------NLDKGDLENIWDCSM--VKHIALLLFTNCILNCPVA 783
Cdd:cd14969 160 NSLSYIVSLFV---FCFFLplaiIIFCYYKIYRtlrkmskraarRKNSAITKRTKKAEKkvAKMVLVMIVAFLIAWTPYA 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 21542118 784 FLSFSSLIN-LTFISPevikfiLLVVVP-----LPACLNPLLYILFNPHFKE 829
Cdd:cd14969 237 VVSLYVSFGgESTIPP------LLATIPalfakSSTIYNPIIYVFMNKQFRR 282
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 51-351 5.04e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.79  E-value: 5.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  51 DCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRlagnALTYIPKG--AFTGLYSLKVL-------ML 121
Cdd:COG5238  99 EVSPVALAETATAVATPPPDLRRIMAKTLEDSLILYLALPRRINLI----QVLKDPLGgnAVHLLGLAARLgllaaisMA 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 122 QNNQLRHVPTEALQNLR-----------------SLQSLRLDANHI----SYVPPSCFSGLHSLRHLWLDDNALTEIPVQ 180
Cdd:COG5238 175 KALQNNSVETVYLGCNQigdegieelaealtqntTVTTLWLKRNPIgdegAEILAEALKGNKSLTTLDLSNNQIGDEGVI 254

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 181 AF----RSLSALQAMTLALNKIHHIPDYAFGNL----SSLVVLHLHNNRIHSLGKKCF-DGL---HSLETLDLNYNNLDE 248
Cdd:COG5238 255 ALaealKNNTTVETLYLSGNQIGAEGAIALAKAlqgnTTLTSLDLSVNRIGDEGAIALaEGLqgnKTLHTLNLAYNGIGA 334

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 249 -----FPTAIRTLSNLKELGFHSNNIRSIPEKAF----VGNPSLITIHFYDNPIQFVGRSAfqhlpelrtltLNGASQIT 319
Cdd:COG5238 335 qgaiaLAKALQENTTLHSLDLSDNQIGDEGAIALakylEGNTTLRELNLGKNNIGKQGAEA-----------LIDALQTN 403

                       330       340       350
                ....*....|....*....|....*....|..
gi 21542118 320 efpdltgtaNLESLTLTGAQISSLPQTVCNQL 351
Cdd:COG5238 404 ---------RLHTLILDGNLIGAEAQQRLEQL 426
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 139-284 2.39e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 44.84  E-value: 2.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   139 SLQSLRLDaNHISYVPPSCFSGLHSLRHLWLDDNaLTEIPVQAFrSLSALQAMTLAlNKIHHIPDYAFGNLSSLVVLHLH 218
Cdd:pfam13306  12 SLTSITIP-SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAF-YNCSLTSITIP-SSLTSIGEYAFSNCSNLKSITLP 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21542118   219 NNrIHSLGKKCFdglhsletldlnYNnldefptairtlSNLKELGFHSnNIRSIPEKAFVGNPSLI 284
Cdd:pfam13306  88 SN-LTSIGSYAF------------SN------------CSLKSITIPS-SVTTIGSYAFSNCSNLK 127
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 310-453 3.35e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 3.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 310 LTLNGaSQITEFPDLTGTANLESLTLTGAQISSLPQtvCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEI--- 386
Cdd:cd21340   7 LYLND-KNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRIsvv 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 387 ---------YEIKVDTfQQL-----------------LSLRSLNLAWNKIAIIHPnaFSTLPSLIKLDLSSNLLSSF--- 437
Cdd:cd21340  84 eglenltnlEELHIEN-QRLppgekltfdprslaalsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLeel 160

                       170
                ....*....|....*...
gi 21542118 438 --PITGLHGLTHLKLTGN 453
Cdd:cd21340 161 ldLLSSWPSLRELDLTGN 178
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 575-820 3.43e-05

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 46.52  E-value: 3.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   575 NALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSfarhgawWENG-VGCHVIGFLSIFASESSVF 653
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGD-------WPFGsALCKIVGALFVVNGYASIL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   654 LLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGA----SPLCLP-LPFGEPSTMGYMVA 728
Cdd:pfam00001  75 LLTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVpegnVTVCFIdFPEDLSKPVSYTLL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   729 LILLNSLC-FLMMTIAYTKLYC------NLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVI 801
Cdd:pfam00001 155 ISVLGFLLpLLVILVCYTLIIRtlrksaSKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLL 234

                         250       260
                  ....*....|....*....|..
gi 21542118   802 KFILLVVVPLP---ACLNPLLY 820
Cdd:pfam00001 235 DKALSVTLWLAyvnSCLNPIIY 256
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 352-384 7.19e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.69  E-value: 7.19e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 21542118   352 PNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHN 384
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
PLN03150 PLN03150
hypothetical protein; Provisional
 67-178 8.53e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 46.35  E-value: 8.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   67 FTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLD 146
Cdd:PLN03150 419 FIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLN 498

                         90       100       110
                 ....*....|....*....|....*....|....
gi 21542118  147 ANHISYVPPSCFSG--LHSLRHLWLDDNALTEIP 178
Cdd:PLN03150 499 GNSLSGRVPAALGGrlLHRASFNFTDNAGLCGIP 532
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 564-829 9.72e-05

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 44.86  E-value: 9.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 564 VWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFtfgsfarHGAWWENGVGCHVIGFL 643
Cdd:cd14967   6 LSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTL-------LGYWPFGPVLCRFWIAL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 644 SIFASESSVFLLTLAALERGFSV----KYSAKFETKapfsSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGE 719
Cdd:cd14967  79 DVLCCTASILNLCAISLDRYLAItrplRYRQLMTKK----RALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFT 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 720 PSTmGYMVALILLNSLC-FLMMTIAYTKLYCNLDKgdleniwDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTF-IS 797
Cdd:cd14967 155 PNK-IYVLVSSVISFFIpLLIMIVLYARIFRVARR-------ELKAAKTLAIIVGAFLLCWLPFFIIYLVSAFCPPDcVP 226

                       250       260       270
                ....*....|....*....|....*....|..
gi 21542118 798 PEVIKFILLVVVpLPACLNPLLYILFNPHFKE 829
Cdd:cd14967 227 PILYAVFFWLGY-LNSALNPIIYALFNRDFRR 257
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 86-376 1.37e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  86 LPSLRFLEELRLAGNALTYIpkgaftglySLKVLmlqnnqlrhvpTEALQNLRSLQSLRLDANHISYVPP---SCFSGLH 162
Cdd:cd00116  19 LPKLLCLQVLRLEGNTLGEE---------AAKAL-----------ASALRPQPSLKELCLSLNETGRIPRglqSLLQGLT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 163 S---LRHLWLDDNALTEI---PVQAFRSLSALQAMTLALNKI-----HHIPDYAFGNLSSLVVLHLHNNRIHSLG----K 227
Cdd:cd00116  79 KgcgLQELDLSDNALGPDgcgVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLEGAScealA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 228 KCFDGLHSLETLDLNYNNLDEFptAIRTL-------SNLKELGFHSNNIRSIPEKAFVG----NPSLITIHFYDNPIQFV 296
Cdd:cd00116 159 KALRANRDLKELNLANNGIGDA--GIRALaeglkanCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNNLTDA 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 297 GRSAF-----QHLPELRTLTLNGASqitefpdltgtanlesLTLTGAQisSLPQtVCNQLPNLQVLDLSYNLLEDLPSFS 371
Cdd:cd00116 237 GAAALasallSPNISLLTLSLSCND----------------ITDDGAK--DLAE-VLAEKESLLELDLRGNKFGEEGAQL 297


                ....*
gi 21542118 372 VCQKL 376
Cdd:cd00116 298 LAESL 302
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 56-246 1.67e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.65  E-value: 1.67e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  56 GLSELPSNLSVftsyLDLSMNNISQL----LPNPLPSLRFLEELRLAGNALTyiPKG------AFTGLYSLKVLMLQNNQ 125
Cdd:cd00116 131 GLKDLPPALEK----LVLGRNRLEGAsceaLAKALRANRDLKELNLANNGIG--DAGiralaeGLKANCNLEVLDLNNNG 204

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 126 LRHVPTEALQnlrslqslrldanhisyvppSCFSGLHSLRHLWLDDNALTEIPVQAFrsLSALQAMtlalnkihhipdya 205
Cdd:cd00116 205 LTDEGASALA--------------------ETLASLKSLEVLNLGDNNLTDAGAAAL--ASALLSP-------------- 248

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 21542118 206 fgnLSSLVVLHLHNNRIHSLGKKCF----DGLHSLETLDLNYNNL 246
Cdd:cd00116 249 ---NISLLTLSLSCNDITDDGAKDLaevlAEKESLLELDLRGNKF 290
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 100-212 2.79e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 41.76  E-value: 2.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   100 NALTYIPKGAFTGLYSLKVLMLQNNqLRHVPTEALQNLrSLQSLRLDANhISYVPPSCFSGLHSLRHLWLDDNaLTEIPV 179
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITLPSN-LTSIGS 95

                          90       100       110
                  ....*....|....*....|....*....|...
gi 21542118   180 QAFRSlSALQAMTLAlNKIHHIPDYAFGNLSSL 212
Cdd:pfam13306  96 YAFSN-CSLKSITIP-SSVTTIGSYAFSNCSNL 126
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-65 4.85e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 4.85e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 21542118    33 GCPTHCHCEPdgrmlLRVDCSDLGLSELPSNLS 65
Cdd:pfam01462   1 ACPVPCHCSA-----TVVNCSDRGLTAVPRDLP 28
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-70 5.54e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.07  E-value: 5.54e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 21542118     33 GCPTHCHCEPdgrmlLRVDCSDLGLSELPSNLSVFTSY 70
Cdd:smart00013   1 ACPAPCNCSG-----TAVDCSGRGLTEVPLDLPPDTTL 33
LRR_8 pfam13855
Leucine rich repeat;
70-126 5.75e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 5.75e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 21542118    70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQL 126
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 211-261 6.14e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 6.14e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 21542118   211 SLVVLHLHNNRIHSLGKkcFDGLHSLETLDLNYNNLdefptaIRTLSNLKE 261
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNK------ITDLSDLAN 44
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
167-438 8.52e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.15  E-value: 8.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  167 LWLDDNALTEIPVQAfrslsALQAMTLAL--NKIHHIPDYAFGNLSSLVVlhlHNNRIHSLGKKCFDglhSLETLDLNYN 244
Cdd:PRK15370 183 LRLKILGLTTIPACI-----PEQITTLILdnNELKSLPENLQGNIKTLYA---NSNQLTSIPATLPD---TIQEMELSIN 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  245 NLDEFPTaiRTLSNLKELGFHSNNIRSIPEKAFVGnpsLITIHFYDNPIqfvgRSAFQHLPelrtltlngaSQITEFpdl 324
Cdd:PRK15370 252 RITELPE--RLPSALQSLDLFHNKISCLPENLPEE---LRYLSVYDNSI----RTLPAHLP----------SGITHL--- 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  325 tgtaNLESLTLTgaqisSLPQTVCnqlPNLQVLDLSYNLLEDLPSfSVCQKLQKIDLRHNEIyeikvdtfqqllslrsln 404
Cdd:PRK15370 310 ----NVQSNSLT-----ALPETLP---PGLKTLEAGENALTSLPA-SLPPELQVLDVSKNQI------------------ 358

                        250       260       270
                 ....*....|....*....|....*....|....
gi 21542118  405 lawnkiaIIHPNAFStlPSLIKLDLSSNLLSSFP 438
Cdd:PRK15370 359 -------TVLPETLP--PTITTLDVSRNALTNLP 383
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 57-427 1.33e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.08  E-value: 1.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118  57 LSELPSNLSVFTSYLDLSMnnisQLLPNPLPSLRFLEELRLAGNALTYIPKGAftglYSLKVLMLQNNQlRHVPTEALQn 136
Cdd:COG5238  49 LARYLQSRSSITQYLRFEG----QGDPGLNPVALEKAAEAFPTQLLVVDWEGA----EEVSPVALAETA-TAVATPPPD- 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 137 lrslqsLRLDANHISYvppscfsGLHSLRHlwlddNALTEIPVQA-FRSLSALQAMTLALNKIHHIPDYAFGnlsslvvl 215
Cdd:COG5238 119 ------LRRIMAKTLE-------DSLILYL-----ALPRRINLIQvLKDPLGGNAVHLLGLAARLGLLAAIS-------- 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 216 hlhnnrihslgKKCFDGLHSLETLDLNYNNLDEfptairtlSNLKELGfhsnnirsipeKAFVGNPSLITIHFYDNPIQF 295
Cdd:COG5238 173 -----------MAKALQNNSVETVYLGCNQIGD--------EGIEELA-----------EALTQNTTVTTLWLKRNPIGD 222

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 296 VGRSAF----QHLPELRTLTLN-------GASQITEFpdLTGTANLESLTLTGAQIS-----SLPQTVCNQlPNLQVLDL 359
Cdd:COG5238 223 EGAEILaealKGNKSLTTLDLSnnqigdeGVIALAEA--LKNNTTVETLYLSGNQIGaegaiALAKALQGN-TTLTSLDL 299

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 360 SYNLLED------LPSFSVCQKLQKIDLRHNEI----YEIKVDTFQQLLSLRSLNLAWNKI----AIIHPNAFSTLPSLI 425
Cdd:COG5238 300 SVNRIGDegaialAEGLQGNKTLHTLNLAYNGIgaqgAIALAKALQENTTLHSLDLSDNQIgdegAIALAKYLEGNTTLR 379


                ..
gi 21542118 426 KL 427
Cdd:COG5238 380 EL 381
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
 567-831 2.37e-03

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 41.11  E-value: 2.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 567 IAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFgsfarhgAWWENGVGCHVIGFLSIF 646
Cdd:cd15074  10 IGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAH-------RWLFGDIGCVFYGFCGFL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 647 ASESSVFLLTLAALER---GFSVKYSAKFETKAPFSSLKVIillcALLALTMAAVPLLGGSKYGasplclPLPFG----- 718
Cdd:cd15074  83 FGCCSINTLTAISIYRylkICHPPYGPKLSRRHVCIVIVAI----WLYALFWAVAPLVGWGSYG------PEPFGtscsi 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 719 -------EPSTMGYMVALILlnsLCFLM----MTIAYTKLYCNLDKGDLENIWDCSMVKHIALL---LFTNCILNC---- 780
Cdd:cd15074 153 dwtgasaSVGGMSYIISIFI---FCYLLpvliIVFSYVKIIRKVKSSRKRVAGFDSRSKRQHKIerkVTKVAVLICagfl 229

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21542118 781 ----PVAFLSFSSlinlTFISPEVIKFILLVVVPLPA---CL-NPLLYILFNPHFKEDL 831
Cdd:cd15074 230 iawtPYAVVSMWS----AFGSPDSVPILASILPALFAkssCMyNPIIYLLFSSKFRQDL 284
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 257-419 4.08e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 38.29  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   257 SNLKELGFhSNNIRSIPEKAFVGNPSLITIHFYDNpIQFVGRSAFQHlpelrtltlngasqitefpdltgtANLESLTLt 336
Cdd:pfam13306  11 CSLTSITI-PSSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYN------------------------CSLTSITI- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   337 GAQISSLPqtvcnqlpnlqvldlSYnlledlpSFSVCQKLQKIDLRHNeIYEIKVDTFQQlLSLRSLNLaWNKIAIIHPN 416
Cdd:pfam13306  64 PSSLTSIG---------------EY-------AFSNCSNLKSITLPSN-LTSIGSYAFSN-CSLKSITI-PSSVTTIGSY 118


                  ...
gi 21542118   417 AFS 419
Cdd:pfam13306 119 AFS 121
PLN03150 PLN03150
hypothetical protein; Provisional
 185-253 5.03e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 5.03e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21542118  185 LSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIH-----SLGKkcfdgLHSLETLDLNYNNLD-EFPTAI 253
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgsipeSLGQ-----LTSLRILNLNGNSLSgRVPAAL 510
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 230-464 5.50e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 5.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 230 FDGLHSLETLDLNYNNLDE-----FPTAIRTLSNLKELGFHSNNIRSIPEkafvgnpslitihfydnpiqFVGR--SAFQ 302
Cdd:cd00116  19 LPKLLCLQVLRLEGNTLGEeaakaLASALRPQPSLKELCLSLNETGRIPR--------------------GLQSllQGLT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 303 HLPELRTLTLN----GASQITEFPDLTGTANLESLTLTGAQISSLP-QTVCNQL----PNLQVLDLSYNLLEDLPS---- 369
Cdd:cd00116  79 KGCGLQELDLSdnalGPDGCGVLESLLRSSSLQELKLNNNGLGDRGlRLLAKGLkdlpPALEKLVLGRNRLEGASCeala 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118 370 --FSVCQKLQKIDLRHNEIYEIKVDTFQQLL----SLRSLNLAWNKI----AIIHPNAFSTLPSLIKLDLSSNllssfPI 439
Cdd:cd00116 159 kaLRANRDLKELNLANNGIGDAGIRALAEGLkancNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDN-----NL 233

                       250       260
                ....*....|....*....|....*...
gi 21542118 440 TgLHGLTHLK---LTGNHALQSLISSEN 464
Cdd:cd00116 234 T-DAGAAALAsalLSPNISLLTLSLSCN 260
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 208-426 8.38e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.86  E-value: 8.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   208 NLSSLVVLHLHN-NRIHSLgkkcFDGLHSLETLDLNYNNLDEFPTAIRtLSNLKELGFHSNNIRSIPEKA-------FVG 279
Cdd:PLN03210  702 NLKSLYRLNLSGcSRLKSF----PDISTNISWLDLDETAIEEFPSNLR-LENLDELILCEMKSEKLWERVqpltplmTML 776

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   280 NPSLITIHFYDNPIQFVGRSAFQHL-----------------------PELRTLTLNGASQITEFPDLtgTANLESLTLT 336
Cdd:PLN03210  777 SPSLTRLFLSDIPSLVELPSSIQNLhklehleiencinletlptginlESLESLDLSGCSRLRTFPDI--STNISDLNLS 854

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21542118   337 GAQISSLPQTVcNQLPNLQVLDLSYnlledlpsfsvCQKLQKIDLRHNEIYEIKVDTFQQLLSLR--SLNLAWNKIAIIH 414
Cdd:PLN03210  855 RTGIEEVPWWI-EKFSNLSFLDMNG-----------CNNLQRVSLNISKLKHLETVDFSDCGALTeaSWNGSPSEVAMAT 922

                         250
                  ....*....|..
gi 21542118   415 PNAFSTLPSLIK 426
Cdd:PLN03210  923 DNIHSKLPSTVC 934
LRR_8 pfam13855
Leucine rich repeat;
305-364 8.54e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 8.54e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21542118   305 PELRTLTLNGaSQITEFPD--LTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLL 364
Cdd:pfam13855   1 PNLRSLDLSN-NRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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