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Conserved domains on  [gi|23396462|sp|O94805|]
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RecName: Full=Actin-like protein 6B; AltName: Full=53 kDa BRG1-associated factor B; AltName: Full=Actin-related protein Baf53b; AltName: Full=ArpNalpha; AltName: Full=BRG1-associated factor 53B; Short=BAF53B

Protein Classification

actin family protein( domain architecture ID 19050495)

actin family protein has well-characterized cytoskeletal functions and has also been implicated in nuclear activities

CATH:  3.30.420.40
Gene Ontology:  GO:0031491|GO:0006338

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ASKHA_NBD_Arp4_ACTL6-like cd13395
nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The ...
8-417 0e+00

nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The Arp4-like subfamily includes Arp4, also called actin-like protein 4, from fungi and plants. Saccharomyces cerevisiae Arp4 acts synergistically with Arp8 to depolymerize F-actin; it binds ATP, but unlike conventional actin, does not form filaments. It is a component of the NuA4 histone acetyltransferase complex, the chromatin-remodeling INO80 complex and the SWR1 chromatin remodeling complex. Arabidopsis thaliana Arp4 is involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure. This family also includes human homologs of yeast and plant, which are actin-like protein 6A (encoded by the ACTL6A gene; also known as ArpNbeta, 53 kDa BRG1-associated factor A/BRG1-associated factor 53A/BAF35A, and INO80 complex subunit K/INO80K) and actin-like protein 6B (encoded by the ACTL6B gene; also known as ArpNalpha, 53 kDa BRG1-associated factor B/BRG1-associated factor 53B/BAF35B). ACTL6A and ACTL6B are involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). They are components of numerous complexes with chromatin remodeling and histone acetyltransferase activity. ACTL6A is also a putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Schizosaccharomyces pombe actin-related protein 42 (Arp42) is also included in this family. It is also a component of SWI/SNF and RSC complexes.


:

Pssm-ID: 466846 [Multi-domain]  Cd Length: 413  Bit Score: 740.15  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   8 GDEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGDKEKKgKIFHIDTNALHVPRDGAEVMSPLKN 87
Cdd:cd13395   1 GDEVGALVLDIGSYSTRAGYAGEDTPKAVFPSVVGVVTDDDDAEDYVGGSGEKK-RKYYIGTNSIGVPRPNMEVISPLKD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  88 GMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVL 167
Cdd:cd13395  80 GLIEDWDAFEKLWDHALKNRLRVDPSEHPLLLTEPSWNTRANREKLTELMFEKYNVPAFFLAKNAVLSAFANGRSTALVV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 168 DSGATHTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKeKLPQVSKSW 247
Cdd:cd13395 160 DSGATSTSVVPVHDGYVLQKAIVRSPLGGDFLTDQLLKLLESKNIEIIPRYMIKSKEPVEGGAPAKYTKK-DLPNTTSSY 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 248 HNYMCNEVIQDFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKG-----LSGNTMLGV 322
Cdd:cd13395 239 HRYMVRRVLQDFKESVCQVSDSPFDESEAASIPTVSYELPDGYNIEFGAERFKIPELLFDPSLVKGipappSEGNELLGL 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 323 GHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERKFSPWIGGSILASLGT 402
Cdd:cd13395 319 PQLVYTSIGSCDVDIRPELYGNVVLTGGNSLLPGFTDRLNRELSEKAPGSLKLKILASGNTVERRFSSWIGGSILASLGS 398
                       410
                ....*....|....*
gi 23396462 403 FQQMWISKQEYEEGG 417
Cdd:cd13395 399 FQQMWISKQEYEEHG 413
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp4_ACTL6-like cd13395
nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The ...
8-417 0e+00

nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The Arp4-like subfamily includes Arp4, also called actin-like protein 4, from fungi and plants. Saccharomyces cerevisiae Arp4 acts synergistically with Arp8 to depolymerize F-actin; it binds ATP, but unlike conventional actin, does not form filaments. It is a component of the NuA4 histone acetyltransferase complex, the chromatin-remodeling INO80 complex and the SWR1 chromatin remodeling complex. Arabidopsis thaliana Arp4 is involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure. This family also includes human homologs of yeast and plant, which are actin-like protein 6A (encoded by the ACTL6A gene; also known as ArpNbeta, 53 kDa BRG1-associated factor A/BRG1-associated factor 53A/BAF35A, and INO80 complex subunit K/INO80K) and actin-like protein 6B (encoded by the ACTL6B gene; also known as ArpNalpha, 53 kDa BRG1-associated factor B/BRG1-associated factor 53B/BAF35B). ACTL6A and ACTL6B are involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). They are components of numerous complexes with chromatin remodeling and histone acetyltransferase activity. ACTL6A is also a putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Schizosaccharomyces pombe actin-related protein 42 (Arp42) is also included in this family. It is also a component of SWI/SNF and RSC complexes.


Pssm-ID: 466846 [Multi-domain]  Cd Length: 413  Bit Score: 740.15  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   8 GDEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGDKEKKgKIFHIDTNALHVPRDGAEVMSPLKN 87
Cdd:cd13395   1 GDEVGALVLDIGSYSTRAGYAGEDTPKAVFPSVVGVVTDDDDAEDYVGGSGEKK-RKYYIGTNSIGVPRPNMEVISPLKD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  88 GMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVL 167
Cdd:cd13395  80 GLIEDWDAFEKLWDHALKNRLRVDPSEHPLLLTEPSWNTRANREKLTELMFEKYNVPAFFLAKNAVLSAFANGRSTALVV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 168 DSGATHTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKeKLPQVSKSW 247
Cdd:cd13395 160 DSGATSTSVVPVHDGYVLQKAIVRSPLGGDFLTDQLLKLLESKNIEIIPRYMIKSKEPVEGGAPAKYTKK-DLPNTTSSY 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 248 HNYMCNEVIQDFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKG-----LSGNTMLGV 322
Cdd:cd13395 239 HRYMVRRVLQDFKESVCQVSDSPFDESEAASIPTVSYELPDGYNIEFGAERFKIPELLFDPSLVKGipappSEGNELLGL 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 323 GHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERKFSPWIGGSILASLGT 402
Cdd:cd13395 319 PQLVYTSIGSCDVDIRPELYGNVVLTGGNSLLPGFTDRLNRELSEKAPGSLKLKILASGNTVERRFSSWIGGSILASLGS 398
                       410
                ....*....|....*
gi 23396462 403 FQQMWISKQEYEEGG 417
Cdd:cd13395 399 FQQMWISKQEYEEHG 413
Actin pfam00022
Actin;
11-426 0e+00

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 569.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462    11 VGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAeeggglelegDKEKKGKIFHIDTNALHvPRDGAEVMSPLKNGMI 90
Cdd:pfam00022   1 VSALVIDNGSHTTRAGFAGEDAPKAVIPSCVGKPRG----------TKVEAANKYYVGDEALT-YRPGMEVRSPVEDGIV 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462    91 EDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSG 170
Cdd:pfam00022  70 VDWDAMEEIWEHVLKEELQVDPEEHPLLLTEPPWNPPANREKAAEIMFEKFGVPALYLAKNPVLSAFASGRTTGLVVDSG 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   171 ATHTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPvreGAPPNWKKKEKLPQVSKSWHNY 250
Cdd:pfam00022 150 AGVTSVVPVHDGYVLQKAIRRSDLGGDFLTDYLRELLRSRNIEITPRYLIKSKKP---GDPAPAVTKRELPDTTYSYKTY 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   251 MCNEVIQDFQASVLQVSDSPY-DEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLSG----NTMLGVGHV 325
Cdd:pfam00022 227 QERRVLEEIKESVCYVSDDPFgDETTSSSIPTRVYELPDGSTIILGAERFRVPEILFNPSLIGSESElpppQTAVGIPEL 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   326 VTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERKFSPWIGGSILASLGTFQQ 405
Cdd:pfam00022 307 IVDAINACDVDLRPSLLANIVVTGGNSLFPGFTERLEKELAQLAPPGVKVKIIAPGNTVERRYSAWIGGSILASLGTFQQ 386
                         410       420
                  ....*....|....*....|.
gi 23396462   406 MWISKQEYEEGGKQCVERKCP 426
Cdd:pfam00022 387 MWVSKQEYEEHGASVVERKCK 407
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
11-425 2.78e-150

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 430.91  E-value: 2.78e-150
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462     11 VGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLElegdkekKGKIFHIDtnALHVPRDGAEVMSPLKNGMI 90
Cdd:smart00268   1 VPAIVIDNGSGTIKAGFAGEDFPQVVFPSIVGRPKDGKGMVGD-------AKDIFVGD--EAQEKRGGLELKYPIENGIV 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462     91 EDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSG 170
Cdd:smart00268  72 ENWDDMEKIWDYTFFNELRVEPEEHPVLLTEPPMNPKSNREKILEIMFETFNFPALYIAIQAVLSLYASGRTTGLVIDSG 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462    171 ATHTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEmaiDIIPPYMIAAKEPVREGappnwkkKEKLPQVSKSWHNY 250
Cdd:smart00268 152 DGVTHVVPVVDGYVLPHAIKRIDIAGRDITDYLKELLSE---RGYQFNSSAEFEIVREI-------KEKLCYVAEDFEKE 221
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462    251 MCNeviqdfqasvlqvsdspYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVkglsGNTMLGVGHVVTTSI 330
Cdd:smart00268 222 MKL-----------------ARESSESSKLEKTYELPDGNTIKVGNERFRIPEILFSPELI----GLEQKGIHELVYESI 280
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462    331 GMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIAsnsTMERKFSPWIGGSILASLGTFQQMWISK 410
Cdd:smart00268 281 QKCDIDVRKDLYENIVLSGGSTLIPGFGERLEKELKQLAPKKLKVKVIA---PPERKYSVWLGGSILASLSTFEDMWITK 357
                          410
                   ....*....|....*
gi 23396462    411 QEYEEGGKQCVERKC 425
Cdd:smart00268 358 KEYEESGSQIVERKC 372
PTZ00004 PTZ00004
actin-2; Provisional
10-425 3.20e-93

actin-2; Provisional


Pssm-ID: 240225 [Multi-domain]  Cd Length: 378  Bit Score: 285.51  E-value: 3.20e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   10 EVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLElegdKEKKGKIF-HIDTnalhvPRDGAEVMSPLKNG 88
Cdd:PTZ00004   5 ETNAAVVDNGSGMVKAGFAGDDAPRCVFPSIVGRPKNPGIMVGM----EEKDCYVGdEAQD-----KRGILTLKYPIEHG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   89 MIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLD 168
Cdd:PTZ00004  76 IVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETHNVPAMYVAIQAVLSLYASGRTTGIVLD 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  169 SG--ATHTtaIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIPPymiAAKEPVREgappnwkKKEKLpqvsks 246
Cdd:PTZ00004 156 SGdgVSHT--VPIYEGYSLPHAIHRLDVAGRDLTEYMMKILHERGTTFTTT---AEKEIVRD-------IKEKL------ 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  247 whnymCnEVIQDFQASvlqvSDSPYDEqvaAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSnvkgLSGNTM-LGVGHV 325
Cdd:PTZ00004 218 -----C-YIALDFDEE----MGNSAGS---SDKYEESYELPDGTIITVGSERFRCPEALFQPS----LIGKEEpPGIHEL 280
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  326 VTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASnstMERKFSPWIGGSILASLGTFQQ 405
Cdd:PTZ00004 281 TFQSINKCDIDIRKDLYGNIVLSGGTTMYRGLPERLTKELTTLAPSTMKIKVVAP---PERKYSVWIGGSILSSLPTFQQ 357
                        410       420
                 ....*....|....*....|
gi 23396462  406 MWISKQEYEEGGKQCVERKC 425
Cdd:PTZ00004 358 MWVTKEEYDESGPSIVHRKC 377
COG5277 COG5277
Actin-related protein [Cytoskeleton];
84-415 8.86e-40

Actin-related protein [Cytoskeleton];


Pssm-ID: 444088  Cd Length: 424  Bit Score: 147.24  E-value: 8.86e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  84 PLKNGMIE-----DWECFRAILDHTYSKHVKSEPNLHP--VLMSEAPWNTRAKREKLTELMFE---QYNIPAFFLCKTAV 153
Cdd:COG5277  83 PLRDGIVRrddedAWRVLKELLRYTFAQFLVVDPEFHGflVVVALSALAPDYMRERLFDIHFEvfsEEGAPAVTIIPQPL 162
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 154 LTAFANGRSTGLVLDSGATHTTAIPVHDGyVLQQGIVKSPLAGDFISMQCRELFQEMAidiippYMIAAKEpvregappn 233
Cdd:COG5277 163 AVAIAEKAVTCVVVEAGHGNSQVAPISRG-PIREGLVALNRGGAEANAITREILKDRG------YSDTARE--------- 226
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 234 wkkkEKLPQVSKSWHNYmcneVIQDFQASVLQVSDSP--YDEQVAAQMPTVHYEMPNgyntdYGAERLRIPEGLFDP--- 308
Cdd:COG5277 227 ----EYVVRVVKEALGL----VPRDLAKAIQKAASNPdsFEAKVRLPNPTVEIELGN-----YAWERFLIGEILFNPnhe 293
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 309 ---------------SNVKGLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLL---QGFTD-------RLNR 363
Cdd:COG5277 294 gfesyiqqgrlriedAVIGDVVLYGEMGLAEAIINSIMKCDVEIQDELYSNIILSGGAFNWsvpPGLEDvavdsvtRVQI 373
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....
gi 23396462 364 ELSQKTPpSMRLKLIASNstmERKFSPWIGGSILASLGTFQQMW--ISKQEYEE 415
Cdd:COG5277 374 ELSELAP-ELKVNVRLVS---DPQYSVWKGAIIYGYALPFSVKWswITKEGWYF 423
syringactin NF040575
syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in ...
356-425 2.97e-14

syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in the plant pathogen Pseudomonas syringae and related species. This model was created, in part, to clarify that the family is real and distinct, rather than an artifact of eukaryotic contamination of bacterial genomic sequence data. As of the creation of this HMM, the family is uncharacterized.


Pssm-ID: 468549 [Multi-domain]  Cd Length: 132  Bit Score: 69.24  E-value: 2.97e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  356 GFTDRLNRELSQKTPPSMRLKLIASnstMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKC 425
Cdd:NF040575  66 GFYEKLKKSITEKAPKGALIGMTLD---PKPESAAWRGAAMYAASEGFVEMAITKQEYDESGPSIVHRKC 132
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp4_ACTL6-like cd13395
nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The ...
8-417 0e+00

nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The Arp4-like subfamily includes Arp4, also called actin-like protein 4, from fungi and plants. Saccharomyces cerevisiae Arp4 acts synergistically with Arp8 to depolymerize F-actin; it binds ATP, but unlike conventional actin, does not form filaments. It is a component of the NuA4 histone acetyltransferase complex, the chromatin-remodeling INO80 complex and the SWR1 chromatin remodeling complex. Arabidopsis thaliana Arp4 is involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure. This family also includes human homologs of yeast and plant, which are actin-like protein 6A (encoded by the ACTL6A gene; also known as ArpNbeta, 53 kDa BRG1-associated factor A/BRG1-associated factor 53A/BAF35A, and INO80 complex subunit K/INO80K) and actin-like protein 6B (encoded by the ACTL6B gene; also known as ArpNalpha, 53 kDa BRG1-associated factor B/BRG1-associated factor 53B/BAF35B). ACTL6A and ACTL6B are involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). They are components of numerous complexes with chromatin remodeling and histone acetyltransferase activity. ACTL6A is also a putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Schizosaccharomyces pombe actin-related protein 42 (Arp42) is also included in this family. It is also a component of SWI/SNF and RSC complexes.


Pssm-ID: 466846 [Multi-domain]  Cd Length: 413  Bit Score: 740.15  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   8 GDEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGDKEKKgKIFHIDTNALHVPRDGAEVMSPLKN 87
Cdd:cd13395   1 GDEVGALVLDIGSYSTRAGYAGEDTPKAVFPSVVGVVTDDDDAEDYVGGSGEKK-RKYYIGTNSIGVPRPNMEVISPLKD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  88 GMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVL 167
Cdd:cd13395  80 GLIEDWDAFEKLWDHALKNRLRVDPSEHPLLLTEPSWNTRANREKLTELMFEKYNVPAFFLAKNAVLSAFANGRSTALVV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 168 DSGATHTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKeKLPQVSKSW 247
Cdd:cd13395 160 DSGATSTSVVPVHDGYVLQKAIVRSPLGGDFLTDQLLKLLESKNIEIIPRYMIKSKEPVEGGAPAKYTKK-DLPNTTSSY 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 248 HNYMCNEVIQDFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKG-----LSGNTMLGV 322
Cdd:cd13395 239 HRYMVRRVLQDFKESVCQVSDSPFDESEAASIPTVSYELPDGYNIEFGAERFKIPELLFDPSLVKGipappSEGNELLGL 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 323 GHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERKFSPWIGGSILASLGT 402
Cdd:cd13395 319 PQLVYTSIGSCDVDIRPELYGNVVLTGGNSLLPGFTDRLNRELSEKAPGSLKLKILASGNTVERRFSSWIGGSILASLGS 398
                       410
                ....*....|....*
gi 23396462 403 FQQMWISKQEYEEGG 417
Cdd:cd13395 399 FQQMWISKQEYEEHG 413
Actin pfam00022
Actin;
11-426 0e+00

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 569.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462    11 VGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAeeggglelegDKEKKGKIFHIDTNALHvPRDGAEVMSPLKNGMI 90
Cdd:pfam00022   1 VSALVIDNGSHTTRAGFAGEDAPKAVIPSCVGKPRG----------TKVEAANKYYVGDEALT-YRPGMEVRSPVEDGIV 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462    91 EDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSG 170
Cdd:pfam00022  70 VDWDAMEEIWEHVLKEELQVDPEEHPLLLTEPPWNPPANREKAAEIMFEKFGVPALYLAKNPVLSAFASGRTTGLVVDSG 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   171 ATHTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPvreGAPPNWKKKEKLPQVSKSWHNY 250
Cdd:pfam00022 150 AGVTSVVPVHDGYVLQKAIRRSDLGGDFLTDYLRELLRSRNIEITPRYLIKSKKP---GDPAPAVTKRELPDTTYSYKTY 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   251 MCNEVIQDFQASVLQVSDSPY-DEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLSG----NTMLGVGHV 325
Cdd:pfam00022 227 QERRVLEEIKESVCYVSDDPFgDETTSSSIPTRVYELPDGSTIILGAERFRVPEILFNPSLIGSESElpppQTAVGIPEL 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   326 VTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERKFSPWIGGSILASLGTFQQ 405
Cdd:pfam00022 307 IVDAINACDVDLRPSLLANIVVTGGNSLFPGFTERLEKELAQLAPPGVKVKIIAPGNTVERRYSAWIGGSILASLGTFQQ 386
                         410       420
                  ....*....|....*....|.
gi 23396462   406 MWISKQEYEEGGKQCVERKCP 426
Cdd:pfam00022 387 MWVSKQEYEEHGASVVERKCK 407
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
11-425 2.78e-150

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 430.91  E-value: 2.78e-150
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462     11 VGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLElegdkekKGKIFHIDtnALHVPRDGAEVMSPLKNGMI 90
Cdd:smart00268   1 VPAIVIDNGSGTIKAGFAGEDFPQVVFPSIVGRPKDGKGMVGD-------AKDIFVGD--EAQEKRGGLELKYPIENGIV 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462     91 EDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSG 170
Cdd:smart00268  72 ENWDDMEKIWDYTFFNELRVEPEEHPVLLTEPPMNPKSNREKILEIMFETFNFPALYIAIQAVLSLYASGRTTGLVIDSG 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462    171 ATHTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEmaiDIIPPYMIAAKEPVREGappnwkkKEKLPQVSKSWHNY 250
Cdd:smart00268 152 DGVTHVVPVVDGYVLPHAIKRIDIAGRDITDYLKELLSE---RGYQFNSSAEFEIVREI-------KEKLCYVAEDFEKE 221
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462    251 MCNeviqdfqasvlqvsdspYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVkglsGNTMLGVGHVVTTSI 330
Cdd:smart00268 222 MKL-----------------ARESSESSKLEKTYELPDGNTIKVGNERFRIPEILFSPELI----GLEQKGIHELVYESI 280
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462    331 GMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIAsnsTMERKFSPWIGGSILASLGTFQQMWISK 410
Cdd:smart00268 281 QKCDIDVRKDLYENIVLSGGSTLIPGFGERLEKELKQLAPKKLKVKVIA---PPERKYSVWLGGSILASLSTFEDMWITK 357
                          410
                   ....*....|....*
gi 23396462    411 QEYEEGGKQCVERKC 425
Cdd:smart00268 358 KEYEESGSQIVERKC 372
ASKHA_NBD_actin_Arp-T1-3 cd13397
nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar ...
13-417 7.42e-103

nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar proteins; The family includes actin and human actin-related proteins T1, T2, and T3. Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Arp-T1, encoded by ACTRT1/ARPT1 gene expressed in testis, negatively regulates the Hedgehog (SHH) signaling, binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. Arp-T2 (also called actin-related protein M2; encoded by ACTRT2/ARPM2 gene expressed in testis and various other cell types) and Arp-T3 (also called actin-related protein M1; encoded by ACTRT3/ARPM1 gene expressed in all tested human tissues) play general roles in the organization of the cytoskeleton like other cytoplasmic actin-related proteins.


Pssm-ID: 466848 [Multi-domain]  Cd Length: 359  Bit Score: 309.50  E-value: 7.42e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  13 ALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGlelegdkEKKGKIFHIDTNALHvPRDGAEVMSPLKNGMIED 92
Cdd:cd13397   2 AVVIDNGSGLIKAGFAGEDLPRAVFPSVVGRPKYKAVML-------GAGQKEVYVGDEAQE-KRGVLTLSYPIEHGIVTN 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  93 WECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGAT 172
Cdd:cd13397  74 WDDMEKIWHHTFENELRVKPEEHPVLLTEAPLNPKQNREKMAEIMFETFGVPAFYVAIQAVLSLYSSGRTTGLVLDSGDG 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 173 HTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIPPymiAAKEPVREgappnwkKKEKLPQVSkswhnymc 252
Cdd:cd13397 154 VTHTVPIYEGYALPHAVQRLDLAGRDLTEYLMKLLKERGHSFTTT---AEREIVRD-------IKEKLCYVA-------- 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 253 neviQDFQAsVLQVSDSPYDEqvaaqmptvHYEMPNGYNTDYGAERLRIPEGLFDPSNVkglsGNTMLGVGHVVTTSIGM 332
Cdd:cd13397 216 ----LDYEE-ELKKKSEELEK---------EYTLPDGQVIKIGSERFRCPEALFRPSLI----GREAPGIHKLVYNSIMK 277
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 333 CDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNstmERKFSPWIGGSILASLGTFQQMWISKQE 412
Cdd:cd13397 278 CDIDIRKDLYSNIVLSGGSTMFPGLPERLQKELEALAPSSTKVKVIAPP---ERKYSVWIGGSILASLSTFKSMWITRAE 354

                ....*
gi 23396462 413 YEEGG 417
Cdd:cd13397 355 YDEFG 359
PTZ00004 PTZ00004
actin-2; Provisional
10-425 3.20e-93

actin-2; Provisional


Pssm-ID: 240225 [Multi-domain]  Cd Length: 378  Bit Score: 285.51  E-value: 3.20e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   10 EVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLElegdKEKKGKIF-HIDTnalhvPRDGAEVMSPLKNG 88
Cdd:PTZ00004   5 ETNAAVVDNGSGMVKAGFAGDDAPRCVFPSIVGRPKNPGIMVGM----EEKDCYVGdEAQD-----KRGILTLKYPIEHG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   89 MIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLD 168
Cdd:PTZ00004  76 IVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETHNVPAMYVAIQAVLSLYASGRTTGIVLD 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  169 SG--ATHTtaIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIPPymiAAKEPVREgappnwkKKEKLpqvsks 246
Cdd:PTZ00004 156 SGdgVSHT--VPIYEGYSLPHAIHRLDVAGRDLTEYMMKILHERGTTFTTT---AEKEIVRD-------IKEKL------ 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  247 whnymCnEVIQDFQASvlqvSDSPYDEqvaAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSnvkgLSGNTM-LGVGHV 325
Cdd:PTZ00004 218 -----C-YIALDFDEE----MGNSAGS---SDKYEESYELPDGTIITVGSERFRCPEALFQPS----LIGKEEpPGIHEL 280
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  326 VTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASnstMERKFSPWIGGSILASLGTFQQ 405
Cdd:PTZ00004 281 TFQSINKCDIDIRKDLYGNIVLSGGTTMYRGLPERLTKELTTLAPSTMKIKVVAP---PERKYSVWIGGSILSSLPTFQQ 357
                        410       420
                 ....*....|....*....|
gi 23396462  406 MWISKQEYEEGGKQCVERKC 425
Cdd:PTZ00004 358 MWVTKEEYDESGPSIVHRKC 377
ASKHA_NBD_actin cd10224
nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein ...
13-421 4.62e-93

nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Actin is a monomeric globular protein (G-actin) that reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. At low salt concentrations, actin exists as a monomer, and as the salt concentration rises F-actin forms, with the consequent hydrolysis of ATP. F-actin assembly is in constant flux with G-actin association occurring at the barbed end (+) and its disassociation at the pointed end (-). Actin monomers that have been released from the pointed end can be reused, if the ADP is exchanged for ATP. F-actin filaments can assemble into higher order structures, for example branched F-actin, and stress fibers. Actin binding proteins regulate actin filament dynamics by a range of functions including actin severing, depolymerizing, capping, stabilizing and de novo actin polymerization. Actins interaction with myosin is the basis of muscular contraction and many aspects of cell motility. In vertebrates there are three main groups of actin isoforms, alpha, beta and gamma. The alpha actins found in muscle tissues are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. In plants there are many isoforms which are probably involved in a variety of functions such as cytoplasmic streaming, cell shape determination, tip growth, graviperception, cell wall deposition, etc.


Pssm-ID: 466823  Cd Length: 365  Bit Score: 284.64  E-value: 4.62e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  13 ALVFDIGSFSVRAGYAGEDCPKADFPTTVGLlaaeeggglelegdKEKKGKIFHIDTNALHVprdGAEVMS--------- 83
Cdd:cd10224   2 ALVVDNGSGMCKAGFAGDDAPRAVFPSIVGR--------------PRHQGVMVGMGQKDSYV---GDEAQSkrgiltlky 64
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  84 PLKNGMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRST 163
Cdd:cd10224  65 PIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTT 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 164 GLVLDSG--ATHTtaIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIppyMIAAKEPVREgappnwkKKEKLP 241
Cdd:cd10224 145 GIVLDSGdgVSHT--VPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFT---TTAEREIVRD-------IKEKLC 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 242 QVSkswhnymcneviQDFQASVLQVSDSPYDEQvaaqmptvHYEMPNGYNTDYGAERLRIPEGLFDPSnvkgLSGNTMLG 321
Cdd:cd10224 213 YVA------------LDFEQEMQTAASSSSLEK--------SYELPDGQVITIGNERFRCPEALFQPS----FLGMEAAG 268
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 322 VGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNstmERKFSPWIGGSILASLG 401
Cdd:cd10224 269 IHETTYNSIMKCDVDIRKDLYANIVLSGGTTMFPGIADRMQKEITALAPSTMKIKIVAPP---ERKYSVWIGGSILASLS 345
                       410       420
                ....*....|....*....|
gi 23396462 402 TFQQMWISKQEYEEGGKQCV 421
Cdd:cd10224 346 TFQQMWISKQEYDESGPSIV 365
ASKHA_NBD_actin-like cd10169
nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ...
14-417 9.22e-90

nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ubiquitous in eukaryotes, and the major component of the actin cytoskeleton; monomeric globular protein (G-actin) reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. F-actin filaments form with the consequent hydrolysis of ATP. Some actin-related proteins (Arps) have roles in cytoskeletal functions, such as actin polymerization (Arp2/3) and dynein motor activity (Arp1). Both conventional actin and specific Arps have been implicated in chromatin remodeling and/or transcription regulation. The actin/ARP family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466810 [Multi-domain]  Cd Length: 258  Bit Score: 272.44  E-value: 9.22e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  14 LVFDIGSFSVRAGYAGEDCPKADFPttvgllaaeeggglelegdkekkgkifhidtnalhvprdgaevmsplkngmiedW 93
Cdd:cd10169   1 IVIDNGSGTIKAGFAGEDAPRLIFP------------------------------------------------------W 26
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  94 ECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATH 173
Cdd:cd10169  27 DDMEKIWEHVFYNLLRVDPEEHPVLLTEPPLNPKANREKLAEILFETFNVPSLYIANQAVLSLYASGRTTGLVVDSGEGV 106
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 174 TTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELfqemaidiippymiaakepvregappnwkkkekLPQVSKSWHNYMCN 253
Cdd:cd10169 107 THIVPVYEGYVLPHAVRRLDIGGRDLTDYLAKL---------------------------------LREKGYSFSTSAER 153
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 254 EVIQDfqasvlqvsdspydeqvaaqmptvhyempngyntdygaerlripeglfdpsnVKglsgNTMLGVGHVVTTSIGMC 333
Cdd:cd10169 154 EIVRD----------------------------------------------------IK----EKLCGLHELIYDSIMKC 177
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 334 DIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASnstMERKFSPWIGGSILASLGTFQQMWISKQEY 413
Cdd:cd10169 178 DIDLRKELYSNIVLSGGTTLFPGFAERLQKELSKLAPSSVKVKVIAP---PERKYSAWIGGSILASLSTFQQMWITKEEY 254

                ....
gi 23396462 414 EEGG 417
Cdd:cd10169 255 EEHG 258
ASKHA_NBD_Arp1 cd10216
nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, ...
14-425 4.21e-88

nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, also called centractin, actin-like protein, alpha-centractin, actin-RPV, or centrosome-associated actin homolog, may be a component of a multi-subunit centrosomal complex involved in microtubule-based vesicle motility. In yeast, actin-related protein is essential for viability and is associated with the centrosome. In vertebrates, Arp1 is a core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding. The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. ARP1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. It is required for proper orientation of the mitotic spindle. Arp1 is the only actin-related protein known to form actin-like filaments. Human Arp1/centractin is encoded by the ACTR1A gene.


Pssm-ID: 466820 [Multi-domain]  Cd Length: 370  Bit Score: 272.11  E-value: 4.21e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  14 LVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGD-------KEKKGkIFHIDtnalhvprdgaevmSPLK 86
Cdd:cd10216   4 VVIDNGSGVIKAGFAGDDIPKVVFPSYVGRPKHVRVMAGALEGDvfvgpkaEEHRG-LLKIR--------------YPME 68
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  87 NGMIEDWECFRAILDHTYSK---HVKSEPnlHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRST 163
Cdd:cd10216  69 HGIVTDWNDMERIWQYVYSKlqlNTFSEE--HPVLLTEAPLNPRKNREKAAEVFFETFNVPALFVSMQAVLSLYASGRTT 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 164 GLVLDSGATHTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIippYMIAAKEPVREgappnwkKKEKLPQV 243
Cdd:cd10216 147 GVVLDSGDGVTHAVPIYEGFALPHSIRRVDIAGRDVTEYLQLLLRKSGYNF---HTSAEFEIVRE-------IKEKACYV 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 244 SKswhnymcneviqDFQAsvlqvsdspyDEQVAAQMP-TVHYEMPNGYNTDYGAERLRIPEGLFDPSnvkgLSGNTMLGV 322
Cdd:cd10216 217 AL------------NPQK----------EEKLEEEKTeKAQYTLPDGSTIEIGPERFRAPEILFNPE----LIGLEYPGV 270
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 323 GHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNstmERKFSPWIGGSILASLGT 402
Cdd:cd10216 271 HEVLVDSIQKSDLDLRKTLYSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIRISAPP---ERLYSTWIGGSILASLST 347
                       410       420
                ....*....|....*....|...
gi 23396462 403 FQQMWISKQEYEEGGKQCVERKC 425
Cdd:cd10216 348 FKKMWVSKKEYEEDGARILHRKT 370
PTZ00281 PTZ00281
actin; Provisional
9-425 5.14e-85

actin; Provisional


Pssm-ID: 173506 [Multi-domain]  Cd Length: 376  Bit Score: 264.64  E-value: 5.14e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462    9 DEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGDKekkgkifHIDTNAlHVPRDGAEVMSPLKNG 88
Cdd:PTZ00281   4 EDVQALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDS-------YVGDEA-QSKRGILTLKYPIEHG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   89 MIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLD 168
Cdd:PTZ00281  76 IVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMD 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  169 SGATHTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIppyMIAAKEPVREgappnwkKKEKLPQVSkswh 248
Cdd:PTZ00281 156 SGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYMMKILTERGYSFT---TTAEREIVRD-------IKEKLAYVA---- 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  249 nymcneviQDFQASVLQVSDSPYDEQvaaqmptvHYEMPNGYNTDYGAERLRIPEGLFDPSnvkgLSGNTMLGVGHVVTT 328
Cdd:PTZ00281 222 --------LDFEAEMQTAASSSALEK--------SYELPDGQVITIGNERFRCPEALFQPS----FLGMESAGIHETTYN 281
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  329 SIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNstmERKFSPWIGGSILASLGTFQQMWI 408
Cdd:PTZ00281 282 SIMKCDVDIRKDLYGNVVLSGGTTMFPGIADRMNKELTALAPSTMKIKIIAPP---ERKYSVWIGGSILASLSTFQQMWI 358
                        410
                 ....*....|....*..
gi 23396462  409 SKQEYEEGGKQCVERKC 425
Cdd:PTZ00281 359 SKEEYDESGPSIVHRKC 375
PTZ00466 PTZ00466
actin-like protein; Provisional
14-424 6.31e-74

actin-like protein; Provisional


Pssm-ID: 240426 [Multi-domain]  Cd Length: 380  Bit Score: 235.99  E-value: 6.31e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   14 LVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELegdkekKGKIFhIDTNALHVpRDGAEVMSPLKNGMIEDW 93
Cdd:PTZ00466  15 IIIDNGTGYIKAGFAGEDVPNLVFPSYVGRPKYKRVMAGAV------EGNIF-VGNKAEEY-RGLLKVTYPINHGIIENW 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   94 ECFRAILDHTYSKhVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATH 173
Cdd:PTZ00466  87 NDMENIWIHVYNS-MKINSEEHPVLLTEAPLNPQKNKEKIAEVFFETFNVPALFISIQAILSLYSCGKTNGTVLDCGDGV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  174 TTAIPVHDGYVLQQGIVKSPLAGdfismqcRELFQEMAIdiippymiaakepvregappnwkkkeKLPQVSKSWHNYMCN 253
Cdd:PTZ00466 166 CHCVSIYEGYSITNTITRTDVAG-------RDITTYLGY--------------------------LLRKNGHLFNTSAEM 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  254 EVIQDFQASVLQVSDSPYDEQVAAQ--MPTVHYEMPNGYNTDYGAERLRIPEGLFDPSnvkgLSGNTMLGVGHVVTTSIG 331
Cdd:PTZ00466 213 EVVKNMKENCCYVSFNMNKEKNSSEkaLTTLPYILPDGSQILIGSERYRAPEVLFNPS----ILGLEYLGLSELIVTSIT 288
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  332 MCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNstmERKFSPWIGGSILASLGTFQQMWISKQ 411
Cdd:PTZ00466 289 RADMDLRRTLYSHIVLSGGTTMFHGFGDRLLNEIRKFAPKDITIRISAPP---ERKFSTFIGGSILASLATFKKIWISKQ 365
                        410
                 ....*....|...
gi 23396462  412 EYEEGGKQCVERK 424
Cdd:PTZ00466 366 EFDEYGSVILHRK 378
ASKHA_NBD_ACTL7 cd10214
nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ...
10-425 2.01e-72

nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ACTL7-like family includes ACTL7A, ACTL7B and ACTL9 (also known as ACTL7C). In mammalian, ACTL7A is expressed in a wide variety of adult tissues, while the ACTL7B is expressed in spermatids through the elongation phase of spermatid development. ACTL7A, also called actin-like-7-alpha, or T-ACTIN-2 in mouse, may play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis. ACTL7B, also called actin-like-7-beta, acts as a key regulator of spermiogenesis that is required for male fertility. ACTL9 is a testis-specific protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.


Pssm-ID: 466819 [Multi-domain]  Cd Length: 368  Bit Score: 231.93  E-value: 2.01e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  10 EVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLelegDKEKKGKIFHIDTNAlHVPRDgaeVMSPLKNGM 89
Cdd:cd10214   2 ETKAVIIDLGTGYCKAGFAGQPRPSYVISSTVGKPPQESAKTG----DNRKETFVGKELANV-EPPLK---LVNPLRHGI 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  90 IEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDS 169
Cdd:cd10214  74 VVDWDCVQDIWEYIFEKEMKILPEEHAVLVSDPPLSPTTNREKYAELMFETFSIPAMHIAYQSRLSLYSYGRTSGLVVES 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 170 GATHTTAIPVHDGYVLQQGIVKSPLAGDFISMQCREL-------FQEMAIDIIPpymiaakepvregappNWKKKeklpq 242
Cdd:cd10214 154 GHGVSYVVPIHEGYNLPHITGRADYAGSDLTAYLMKLlneagnkFTDDQLHIVE----------------DIKKK----- 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 243 vskswhnymCNEVIQDFQasvlqvsdspYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSnvkgLSGNTMLGV 322
Cdd:cd10214 213 ---------CCYVALDFE----------EEMGLPPQEYTVDYELPDGHLITIGKERFRCPEMLFNPS----LIGSKQPGL 269
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 323 GHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLkliaSNSTMERKFSPWIGGSILASLGT 402
Cdd:cd10214 270 HTLTMNSLNKCDANLKKDLAKNILLCGGSTMFDGFPDRFQKELSKLCPNDNPI----VAASPERKYSVWTGGSILASLKS 345
                       410       420
                ....*....|....*....|...
gi 23396462 403 FQQMWISKQEYEEGGKQCVERKC 425
Cdd:cd10214 346 FQQLWVRRREYEERGPFVIYRKC 368
PTZ00452 PTZ00452
actin; Provisional
13-425 2.48e-63

actin; Provisional


Pssm-ID: 185631  Cd Length: 375  Bit Score: 208.46  E-value: 2.48e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   13 ALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGDkekkgkiFHIDTNAlHVPRDGAEVMSPLKNGMIED 92
Cdd:PTZ00452   7 AVVIDNGSGYCKIGIAGDDAPTSCFPAIVGRSKQNDGIFSTFNKE-------YYVGEEA-QAKRGVLAIKEPIQNGIINS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   93 WECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGAT 172
Cdd:PTZ00452  79 WDDIEIIWHHAFYNELCMSPEDQPVFMTDAPMNSKFNRERMTQIMFETFNTPCLYISNEAVLSLYTSGKTIGLVVDSGEG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  173 HTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREgappnwkkkeklpqvskswhnYMC 252
Cdd:PTZ00452 159 VTHCVPVFEGHQIPQAITKINLAGRLCTDYLTQILQELGYSLTEPHQRIIVKNIKE---------------------RLC 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  253 neviqdFQASVLQVSDSPYDEQVAAQMPtvhYEMPNGYNTDYGAERLRIPEGLFDPSnvkgLSGNTMLGVGHVVTTSIGM 332
Cdd:PTZ00452 218 ------YTALDPQDEKRIYKESNSQDSP---YKLPDGNILTIKSQKFRCSEILFQPK----LIGLEVAGIHHLAYSSIKK 284
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  333 CDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNstmERKFSPWIGGSILASLGTFQQMWISKQE 412
Cdd:PTZ00452 285 CDLDLRQELCRNIVLSGGTTLFPGIANRLSNELTNLVPSQLKIQVAAPP---DRRFSAWIGGSIQCTLSTQQPQWIKRQE 361
                        410
                 ....*....|...
gi 23396462  413 YEEGGKQCVERKC 425
Cdd:PTZ00452 362 YDEQGPSIVHRKC 374
ASKHA_NBD_Arp2 cd10220
nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, ...
14-423 2.22e-52

nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, also called actin-like protein 2, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp2 is encoded by the ACTR2 gene.


Pssm-ID: 466821  Cd Length: 381  Bit Score: 179.68  E-value: 2.22e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  14 LVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLElegDKEKKGKIFHIDTNALhvpRDGAEVMSPLKNGMIEDW 93
Cdd:cd10220   3 VVCDNGTGFVKCGFAGSNFPEHVFPSLVGRPILRAEEKVG---DIEIKDIMVGDEASEL---RSMLEVTYPMENGIVRNW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  94 ECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATH 173
Cdd:cd10220  77 DDMEHLWDYTFGEKLKIDPRECKILLTEPPMNPTKNREKMVEVMFEKYGFAGVYVAIQAVLTLYAQGLLTGVVVDSGDGV 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 174 TTAIPVHDGYVLQQGIVKSPLAGdfismqcRElfqemaidiIPPYMI-------------AAKEPVREgappnwkKKEKL 240
Cdd:cd10220 157 THIVPVYEGFSLPHLTRRLDVAG-------RD---------ITRYLIkllllrgyafnrtADFETVRE-------IKEKL 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 241 PQVSkswhnymcneviqdfqasvlqvsdspYD---EQVAAQMPTVH---YEMPNGYNTDYGAERLRIPEGLFDPS--NVK 312
Cdd:cd10220 214 CYVA--------------------------YDielEQKLALETTVLvesYTLPDGRVIKVGGERFEAPEALFQPHliDVE 267
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 313 GlsgntmLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQ-------KTPPSmRLK--LIASNST 383
Cdd:cd10220 268 G------PGIAELLFNTIQAADIDTRPELYKHIVLSGGSTMYPGLPSRLEKEIKQlylervlKGDTE-RLSkfKIRIEDP 340
                       410       420       430       440
                ....*....|....*....|....*....|....*....|.
gi 23396462 384 MERKFSPWIGGSILASLGTFQ-QMWISKQEYEEGGKQCVER 423
Cdd:cd10220 341 PRRKHMVFLGGAVLADIMKDKdEFWITRQEYEEQGVRVLDK 381
PTZ00280 PTZ00280
Actin-related protein 3; Provisional
13-417 2.62e-52

Actin-related protein 3; Provisional


Pssm-ID: 240343 [Multi-domain]  Cd Length: 414  Bit Score: 180.70  E-value: 2.62e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   13 ALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGDKEKkgkiFHIDTNALHVPRdGAEVMSPLKNGMIED 92
Cdd:PTZ00280   6 VVVIDNGTGYTKMGYAGNTEPTYIIPTLIADNSKQSRRRSKKGFEDLD----FYIGDEALAASK-SYTLTYPMKHGIVED 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462   93 WECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFAN----------GRS 162
Cdd:PTZ00280  81 WDLMEKFWEQCIFKYLRCEPEEHYFILTEPPMNPPENREYTAEIMFETFNVKGLYIAVQAVLALRASwtskkakelgGTL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  163 TGLVLDSGATHTTAIPVHDGYVLQQGIVKSPLAGDFISmqcrELFQEMAIDiippymiaakepvREGAPPNWKKKEkLPQ 242
Cdd:PTZ00280 161 TGTVIDSGDGVTHVIPVVDGYVIGSSIKHIPLAGRDIT----NFIQQMLRE-------------RGEPIPAEDILL-LAQ 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  243 VSKSWHNYMCNEVIQDFQAsvlqvsdspYDEQVAAQMPTVHYEMP---NGYNTDYGAERLRIPEGLFDPsnvKGLSGNTM 319
Cdd:PTZ00280 223 RIKEKYCYVAPDIAKEFEK---------YDSDPKNHFKKYTAVNSvtkKPYTVDVGYERFLGPEMFFHP---EIFSSEWT 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  320 LGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKT----------------PPSMRLKLIASNst 383
Cdd:PTZ00280 291 TPLPEVVDDAIQSCPIDCRRPLYKNIVLSGGSTMFKGFDKRLQRDVRKRVdrrlkkaeelsggklkPIPIDVNVVSHP-- 368
                        410       420       430
                 ....*....|....*....|....*....|....
gi 23396462  384 MERkFSPWIGGSILASLGTFQQMWISKQEYEEGG 417
Cdd:PTZ00280 369 RQR-YAVWYGGSMLASSPEFEKVCHTKAEYDEYG 401
ASKHA_NBD_Arp3-like cd10221
nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, ...
13-417 1.69e-44

nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, also called actin-like protein 3, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp3 and Arp3B are encoded by the ACTR3 and ACTR3B genes respectively. Arp3B is also known as actin-related protein Arp4.


Pssm-ID: 466822  Cd Length: 404  Bit Score: 159.66  E-value: 1.69e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  13 ALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGDKEKKGKIFHIDTNALHVPRdGAEVMSPLKNGMIED 92
Cdd:cd10221   1 AVVIDNGTGYTKMGYAGNTEPQFIIPTVIAIKESAKVGDGQRRSKKGIEDLDFYIGDEALANSP-TYALKYPIRHGIVED 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  93 WECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRS--------TG 164
Cdd:cd10221  80 WDLMERFWEQCIFKYLRCEPEDHYFLLTEPPLNPPENREYTAEIMFETFNVPGLYIAVQAVLALAASWTSrkvgertlTG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 165 LVLDSGATHTTAIPVHDGYVLQQGIVKSPLAG----DFISMQCRElfQEmaiDIIPPYMI--AAKepvregappnwKKKE 238
Cdd:cd10221 160 TVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGrditYFIQQLLRE--RE---EGIPPEDSleVAK-----------RIKE 223
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 239 KlpqvskswHNYMCNEVIQDFQAsvlqvsdspYDEQVAAQMptVHYEMPNG-----YNTDYGAERLRIPEGLFDPsnvKG 313
Cdd:cd10221 224 R--------YCYVCPDIVKEFAK---------YDSDPAKYI--KQYTGINSvtgkpYTVDVGYERFLAPEIFFNP---EI 281
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 314 LSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTppSMRLKLIASNST---------- 383
Cdd:cd10221 282 ASSDFTTPLPEVVDQVIQSCPIDTRRGLYKNIVLSGGSTMFKDFGRRLQRDVKRIV--DARLKASEELSGgklkpkpidv 359
                       410       420       430       440
                ....*....|....*....|....*....|....*....|
gi 23396462 384 ------MERkFSPWIGGSILASLGTFQQMWISKQEYEEGG 417
Cdd:cd10221 360 nvishpMQR-YAVWFGGSMLASTPEFYTVCHTKAEYEEYG 398
ASKHA_NBD_Arp6 cd10210
nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, ...
14-417 3.63e-44

nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, also called actin-like protein 6, is required for formation and/or maintenance of proper nucleolar structure and function, plays a dual role in the regulation of ribosomal DNA (rDNA) transcription. In the presence of high glucose, Arp6 maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, it is required for the repression of rDNA transcription, and this function may be independent of H2A.Z. Arp6 is also required for telomere silencing in both fission and budding yeast. It is a component of the budding yeast and Arabidopsis SWR1 complex (SWR1C) and the human SWI2/SNF2-related CBP activator protein (SRCAP) chromatin remodeling complexes which catalyze the exchange of the histone H2A with the H2AZ. Drosophila Arp6 colocalizes with HP1 (heterochromatin protein 1) in the pericentric heterochromatin, and vertebrate Arp6 also interacts with HP1. Human Arp6 is encoded by the ACTR6 gene. Arabidopsis thaliana ACTIN RELATED PROTEIN 6/EARLY IN SHORT DAYS 1/SUPPRESSOR OF FRIGIDA 3 (encoded by ARP6/ESD1/SUF3) participates in regulating several leaf and flower development stages. It is needed for Flowering locus C (FLC, the master repressor of flowering) and FLC-like gene expression in the shoot and root apex, and for the activity of the floral repressor pathway.


Pssm-ID: 466816 [Multi-domain]  Cd Length: 389  Bit Score: 158.10  E-value: 3.63e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  14 LVFDIGSFSVRAGYAGEDCPKAdFPTTVGLlaaeeggglelegDKEKKGKIF-------HIDTNALHVPRdgaevmsPLK 86
Cdd:cd10210   2 LVLDNGAYTIKAGFASDDPPRV-IPNCIAK-------------PKSERRRLFgddqldeCKDLSGLFYRR-------PFE 60
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  87 NGMIEDWECFRAILDHTYSKH-VKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFA------- 158
Cdd:cd10210  61 RGYLVNWDLQRQIWDHLFGKLlLNVDPSDTALVLTEPPFNPPSIQEAMDEIVFEEYGFQSLYRTTAAALSAFAyladseq 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 159 ---NGRSTGLVLDSGATHTTAIPVHDGYVLQQGIVKSPLAG--------DFISMqcREL---FQEMAIDIIppymiaake 224
Cdd:cd10210 141 sssSSSQCCLVVDSGFSFTHIVPFFDGKPVKRAVRRIDVGGklltnylkEIISY--RQLnvmDETYLVNQI--------- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 225 pvregappnwkkKEKLPQVSKSW-------------HNYMCNEVIQDFQAS---------VLQVSDSPYDEQVAAqmptv 282
Cdd:cd10210 210 ------------KEDLCFVSTDFyedleiakkkgkeNTIRRDYVLPDYTTSkrgyvrdpeEPNRGKLKEDEQVLR----- 272
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 283 hyeMPNgyntdygaERLRIPEGLFDPSNVkglsGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLN 362
Cdd:cd10210 273 ---LNN--------ERFTVPELLFHPSDI----GIQQAGIAEAIVQSINACPEELQPLLYANIVLTGGNALFPGFRERLE 337
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*
gi 23396462 363 RELSQKTPPSMRLKLIASNSTMErkfSPWIGGSILASLGTFQQMWISKQEYEEGG 417
Cdd:cd10210 338 AELRSLAPDDYDVNVTLPEDPIT---YAWEGGSLLAQSPEFEELAVTRAEYEEHG 389
ASKHA_NBD_ScArp9-like cd10208
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and ...
79-417 7.44e-41

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and similar proteins; Saccharomyces cerevisiae Arp9, also called actin-like protein 9, chromatin structure-remodeling complex protein ARP9, or SWI/SNF complex component ARP9, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp9 forms a stable heterodimer with Arp7 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466814  Cd Length: 356  Bit Score: 148.61  E-value: 7.44e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  79 AEVMSPLKNGMIEDWECFRAILDHTYSK--HVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTA 156
Cdd:cd10208  33 VEIIWPIQDGRVVDWDALEALWRHILFSllSIPRPTNNSPVLLSVPPSWSKSDLELLTQLFFERLNVPAFAILEAPLAAL 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 157 FANGRSTGLVLDSGATHTTAIPVHDGYVLQQGIVKSPLAGDfismQCRELFQEMAidiippymiaakepvregappnwKK 236
Cdd:cd10208 113 YAAGATSGIVVDIGHEKTDITPIVDSQVVPHALVSIPIGGQ----DCTAHLAQLL-----------------------KS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 237 KEKLPQVSKSwhnyMCNEVIQDFqasVLQVSDSPYDEqVAAQMPtvhyEMPNGYNTDYGAERLRIPEGLFDPSNVKGLSG 316
Cdd:cd10208 166 DEPELKSQAE----SGEEATLDL---AEALKKSPICE-VLSDGA----DLASGTEITVGKERFRACEPLFKPSSLRVDLL 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 317 NTMLGVGHVVTTSigmCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMrlKLIASNSTMERKF-------- 388
Cdd:cd10208 234 IAAIAGALVLNAS---DEPDKRPALWENIIIVGGGSRIRGLKEALLSELQQFHLISE--TSASPQQPRIIRLakipdyfp 308
                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 23396462 389 ---------SPWIGGSILASLgTF----QQMWISKQEYEEGG 417
Cdd:cd10208 309 ewkksgyeeAAFLGASIVAKL-VFndpsSKHYISKVDYNEKG 349
COG5277 COG5277
Actin-related protein [Cytoskeleton];
84-415 8.86e-40

Actin-related protein [Cytoskeleton];


Pssm-ID: 444088  Cd Length: 424  Bit Score: 147.24  E-value: 8.86e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  84 PLKNGMIE-----DWECFRAILDHTYSKHVKSEPNLHP--VLMSEAPWNTRAKREKLTELMFE---QYNIPAFFLCKTAV 153
Cdd:COG5277  83 PLRDGIVRrddedAWRVLKELLRYTFAQFLVVDPEFHGflVVVALSALAPDYMRERLFDIHFEvfsEEGAPAVTIIPQPL 162
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 154 LTAFANGRSTGLVLDSGATHTTAIPVHDGyVLQQGIVKSPLAGDFISMQCRELFQEMAidiippYMIAAKEpvregappn 233
Cdd:COG5277 163 AVAIAEKAVTCVVVEAGHGNSQVAPISRG-PIREGLVALNRGGAEANAITREILKDRG------YSDTARE--------- 226
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 234 wkkkEKLPQVSKSWHNYmcneVIQDFQASVLQVSDSP--YDEQVAAQMPTVHYEMPNgyntdYGAERLRIPEGLFDP--- 308
Cdd:COG5277 227 ----EYVVRVVKEALGL----VPRDLAKAIQKAASNPdsFEAKVRLPNPTVEIELGN-----YAWERFLIGEILFNPnhe 293
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 309 ---------------SNVKGLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLL---QGFTD-------RLNR 363
Cdd:COG5277 294 gfesyiqqgrlriedAVIGDVVLYGEMGLAEAIINSIMKCDVEIQDELYSNIILSGGAFNWsvpPGLEDvavdsvtRVQI 373
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....
gi 23396462 364 ELSQKTPpSMRLKLIASNstmERKFSPWIGGSILASLGTFQQMW--ISKQEYEE 415
Cdd:COG5277 374 ELSELAP-ELKVNVRLVS---DPQYSVWKGAIIYGYALPFSVKWswITKEGWYF 423
ASKHA_NBD_AtARP7-like cd10209
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar ...
14-421 2.03e-38

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar proteins; Arabidopsis thaliana ARP7 is an essential nuclear protein, ubiquitously expressed in all cell types. It is needed for normal embryogenesis, plant architecture, and floral organ abscission. It may play a role in regulating various phases of plant development through chromatin-mediated gene regulation.


Pssm-ID: 466815 [Multi-domain]  Cd Length: 354  Bit Score: 142.14  E-value: 2.03e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  14 LVFDIGSFSVRAGYAGEDcpkaDFPTTVGLLaaeeggglelegdkekkgKIFHIDTNALHVPRDG-AEVMSPLKNGMIED 92
Cdd:cd10209   1 VVIDAGSRLLKAGYAYPD----REPSVVEPT------------------RVTPAVEDGEESDTVVeGNTVSPIRRGRIED 58
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  93 WECFRAILDHT-YSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGA 171
Cdd:cd10209  59 WDALEALLRYVfYTGLGWEEGNEGQVLIAEPLLTSKAERERLTQLMFETFNVSGLYASEQAVLSLYAVGRISGCVVDVGH 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 172 THTTAIPVHDGYVLQQGIVKSPLAGdfisMQCRELFqemaidiippymiaAKEPVREGAPPNWKKKEklpqvskswhnym 251
Cdd:cd10209 139 GKIDIAPVWEGAIQHNAVRRFEIGG----RDLTELL--------------AAELGKSNPKVKLDRSI------------- 187
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 252 cnevIQDFQASVLQVSDSP-YDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSnvkgLSGNTMLGVGHVVTTSI 330
Cdd:cd10209 188 ----VERLKEAVAWSADDEeAYEKKVLTCSPETYTLPDGRVISVGKERYCVGEALFRPS----ILGIEEYGIVEQLVRAV 259
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 331 GMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIA-----SNSTMErkFSPWIGGSILASLGTFQQ 405
Cdd:cd10209 260 STSPSENRRQLLENIVLCGGTSSVPGLEARLQKEIRLLSSPSSRPALVKppeymPENTLR--YSAWIGGAILAKVVFPQN 337
                       410
                ....*....|....*.
gi 23396462 406 MWISKQEYEEGGKQCV 421
Cdd:cd10209 338 QHVTKADYDETGPSVV 353
ASKHA_NBD_Arp5 cd10211
nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, ...
13-417 7.15e-30

nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, also called actin-like protein 5, may act as a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. It is involved in DNA double-strand break repair and UV-damage excision repair. Human Arp5 is encoded by the ACTR5 gene. Arabidopsis thaliana ARP5 (AtARp5) is a ubiquitously expressed nuclear protein involved in DNA repair and required for multicellular development of all organs. AtARp5 may be part of other chromatin remodeling machines in addition to INO80.


Pssm-ID: 466817 [Multi-domain]  Cd Length: 345  Bit Score: 118.44  E-value: 7.15e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  13 ALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAaeeggglelegdKEKKGKIFHI---DTNALHVPRDGAEvmSPLKNGM 89
Cdd:cd10211   1 PIVIDNGSYQCRAGWAGDKEPRLVFRNLVAKPR------------DRKKGITVTLvgnDILNDEAVRSHLR--SPFDRNV 66
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  90 IEDWECFRAILDHTYSK-HVKSEPNL-HPVLMSEAPWNTRAKREKLTELMFEQYNIP--AFflcktAVLTAFA------- 158
Cdd:cd10211  67 VTNFDLQEQILDYIFSHlGINSEGSVdHPIVLTEALCNPNYSRQLMSELLFECYGVPsvAY-----GIDSLFSyyhnqpq 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 159 NGRSTGLVLDSGATHTTAIPVHDGyvlqQGIVKsplagdfismQCREL----FQemAIDiippYM---IAAKEPVREGAp 231
Cdd:cd10211 142 GDPSDGLVISSGYSTTHVIPVLNG----RLDLS----------QCKRInlggFH--ATD----YLqrlLQLKYPTHPSA- 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 232 PNWKKKEKLpqvsKSWHNYmcneVIQDFQASVLQVSDSPYDEQ--VAAQMPTvhyempngyntdygaerlripeglfdps 309
Cdd:cd10211 201 ITLSRAEEL----VHEHCY----VAEDYDEELKKWEDPEYYEEnvRKIQLPF---------------------------- 244
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 310 nvkglsgntmlGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLI-ASNSTmerkF 388
Cdd:cd10211 245 -----------GLVETIEFVLKRYPAEQQDRLVQNVFLTGGNALFPGLKERLEKELRAIRPFGSPFNVVrAKDPV----L 309
                       410       420
                ....*....|....*....|....*....
gi 23396462 389 SPWIGGSILASLGTFQQMWISKQEYEEGG 417
Cdd:cd10211 310 DAWRGAAKWALDSTFEKVWITKQEYEEKG 338
ASKHA_NBD_Arp10 cd10207
nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins; ...
15-415 4.74e-29

nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins; Arp10, also known as actin-related protein 11 (Arp11), is a subunit of the cargo-binding portion of the dynein activator, dynactin. It, together with dynactin4 (p62), -5(p25), and -6(p27), forms a heterotetrameric complex located at the pointed end of Arp1. Arp1 forms a mini-filament of uniform size, with proteins bound along its length and at both ends. Human Arp10 is encoded by the ACTR10 gene.


Pssm-ID: 466813 [Multi-domain]  Cd Length: 375  Bit Score: 116.58  E-value: 4.74e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  15 VFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAeeggglelegDKEKKGKIFHIDtnalhvprDGAEVMSPLKngmiedwE 94
Cdd:cd10207   2 VLDIGSAYTKCGFAGESAPRCIIPSEVKLPGG----------KKVIRVVDQRSG--------NEEELYEALK-------E 56
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  95 CFRAIldhtYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATHT 174
Cdd:cd10207  57 FLHEL----YFKHLLVNPKDRRVVVVESVLCPTPFRETLAKVLFKHFEVPSVLFAPSHLLSLLTLGIRTALVVDCGYRET 132
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 175 TAIPVHDGYVLQQGIVKSPLAGDFIsmqCRELfqemaidiippymiaaKEPVREGA--PPNWKKKEKLPQVSKSwhnyMC 252
Cdd:cd10207 133 RVLPVYEGVPLLSAWQSTPLGGKAL---HKRL----------------KKLLLEHAtvVTGDNKGQLLSSVDSL----LS 189
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 253 NEVIQDFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYN-TDY---GAERLRIPEGLFDPSN-VKGLSGNTMLGVGHVVT 327
Cdd:cd10207 190 EEVLEDIKVRACFVTSLERGKTLQSATEEGSTEEPSPPPpVDYpldGEKILIVPGSIRESAEeLLFEGDNEEKSLPTLIL 269
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 328 TSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELS---QKTPPSMRLKLIASNS-TMERKFSP----WIGGSILAS 399
Cdd:cd10207 270 DSLLKCPIDVRKQLAENIVVIGGTSMLPGFKHRLLEELRallRKPKYFEELAPKTFRFhTPPSVFKPnylaWLGGSIFGA 349
                       410
                ....*....|....*.
gi 23396462 400 LGTFQQMWISKQEYEE 415
Cdd:cd10207 350 LESILGRSLSREAYLQ 365
ASKHA_NBD_ScArp7-like cd10212
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and ...
76-414 5.30e-22

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and similar proteins; Saccharomyces cerevisiae Arp7, also called actin-like protein 7, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp7 forms a stable heterodimer with Arp9 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466818 [Multi-domain]  Cd Length: 424  Bit Score: 97.48  E-value: 5.30e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  76 RDGAEVMSPLKN-GMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTR---AKREKLTELMFEQYNIPAFFLCKT 151
Cdd:cd10212  60 RNGDEVYTLVDSqGLPYNWDALEMQWRYLYDTQLKVSPEELPLVITMPATNGKpdmAILERYYELAFDKLNVPVFQIVIE 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 152 AVLTAFANGRSTGLVLDSGATHTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMaidiippymiAAKEPVREGAP 231
Cdd:cd10212 140 PLAIALSMGKSSAFVIDIGASGCNVTPIIDGIVVKNAVVRSKFGGDFLDFQVHERLAPL----------IKEENDMENMA 209
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 232 PNWKKKEKLPQVSKSWhnymcnevIQDFQASVLQVSD-----------------SPYDEQVAAQMPTVHYEMPNGYNTDY 294
Cdd:cd10212 210 DEQKRSTDVWYEASTW--------IQQFKSTMLQVSEkdlfeleryykeqadiyAKQQEQLKQMDQQLQYTALTGSPNNP 281
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 295 GAER-------------------LRIPEGLFDPSNVKGlSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQ 355
Cdd:cd10212 282 LVQKknflfkplnktltldlkecYQFAEYLFKPQLISD-KFSPEDGLGPLMAKSVKKAPEQVYSLLLTNVIITGSTSLIE 360
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 356 GFTDRLNRELSQKTpPSMRLKLIASNSTMERKFSPWIGGSILASLGTFQ-QMWISKQEYE 414
Cdd:cd10212 361 GMEQRIIKELSIRF-PQYKLTTFANQVMMDRKIQGWLGALTMANLPSWSlGKWYSKEDYE 419
ASKHA_NBD_AtArp8-like cd13396
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 8 (AtArp8) and ...
127-413 4.39e-15

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 8 (AtArp8) and similar proteins; Arabidopsis thaliana ARP8, also called F-box protein ARP8, is an F-Box protein localized to the nucleolus. It is ubiquitously expressed in all organs and cell types and has a cell cycle-dependent subcellular pattern of distribution: it is localized to the nucleolus in interphase cells and dispersed in the cytoplasm in mitotic cells.


Pssm-ID: 466847  Cd Length: 332  Bit Score: 75.66  E-value: 4.39e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 127 RAKREKLTELMFE---QYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATHTTAIPVHDGYVLQQ-GIVKSPLAGDFISMQ 202
Cdd:cd13396  77 AASRRQLRGTIFNvlfDMNVPAVCAVDQAVLALYAANRTSGIVVNIGFRVTTIVPVYRGRVMHDiGVEVVGQGALRLTGF 156
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 203 CRELFQEMAIDIIPPYMIAAKepvregappnwkkKEKLPQVSKSWHNymcnEVIQDFQASVlqvsdspydeqvaaqmptv 282
Cdd:cd13396 157 LKELMQQNGIRFPSLYTVRTI-------------KEKLCYVAEDYEA----ELAKDTQASC------------------- 200
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 283 hyEMPNGYNTDYGAERLRIPEGLFDPsnvkGLSGNTMLGVGHVVTTSIGMCDIDIRPG---LYGSVIVTGGNTLLQGFTD 359
Cdd:cd13396 201 --EVAGEGWFTLSNERFKTGEILFQP----GLGGMRAMGLHQAVALCMDHCALVHSQGddgWFKTIVLSGGSACLPGLSE 274
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 23396462 360 RLNRELSQKTPPSMrLKLIASNSTMERKFSPWIGGSILASLGTFQQMW-ISKQEY 413
Cdd:cd13396 275 RLERELRKLLPKSL-SEGIRIIPPPLGPDSAWQGAKLISNLSNFPDGWcITKKQF 328
syringactin NF040575
syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in ...
356-425 2.97e-14

syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in the plant pathogen Pseudomonas syringae and related species. This model was created, in part, to clarify that the family is real and distinct, rather than an artifact of eukaryotic contamination of bacterial genomic sequence data. As of the creation of this HMM, the family is uncharacterized.


Pssm-ID: 468549 [Multi-domain]  Cd Length: 132  Bit Score: 69.24  E-value: 2.97e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462  356 GFTDRLNRELSQKTPPSMRLKLIASnstMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKC 425
Cdd:NF040575  66 GFYEKLKKSITEKAPKGALIGMTLD---PKPESAAWRGAAMYAASEGFVEMAITKQEYDESGPSIVHRKC 132
ASKHA_NBD_Arp8-like cd10206
nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The ...
131-417 4.01e-12

nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The Arp8-like family includes Arp8, also called actin-like protein 8, from vertebrates and fungi. Human Arp8 is encoded by the ACTR8 gene and is also known as INO80 complex subunit N. It plays an important role in the functional organization of mitotic chromosomes. Arp8 exhibits low basal ATPase activity, and is unable to polymerize. It is probably a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication, and probably DNA repair. it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Arp8 strongly prefers nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. This subfamily also contains Arabidopsis thaliana Arp9.


Pssm-ID: 466812 [Multi-domain]  Cd Length: 447  Bit Score: 67.65  E-value: 4.01e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 131 EKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATHTTAIPVHDGYVLQQGIVKSPLAGDFISmqcrELFQEM 210
Cdd:cd10206 202 KELVDLLLRRLGFSSVFVHQESVCATFGAGLSSACVVDIGAQKTSVACVEDGLSIPNSRIRLPYGGDDIT----RCFLWL 277
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 211 aidiippyMIAAKEPVREgappnwkkkeklPQVSKSWHNymcnEVIQDFQASVLQVSDSPydeqVAAQMPTVHYEMPNGy 290
Cdd:cd10206 278 --------LRRSGFPYRE------------CNLNSPLDF----LLLERLKETYCTLDQDD----IGVQLHEFYVREPGQ- 328
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23396462 291 ntdyGAERLRIpeglfdpsNVKGLSgntmlgvgHVVTTSIGMC-DIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKT 369
Cdd:cd10206 329 ----PTLKYQF--------KLLPLD--------EAIVQSILSCaSDELKRKMYSSILLVGGGAKIPGLAEALEDRLLIKI 388
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 23396462 370 PPSM----RLKLIASNSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGG 417
Cdd:cd10206 389 PSLFeaveTVEVLPPPKDMDPSLLAWKGGAVLACLDSAQELWITRKEWQRLG 440
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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