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Conserved domains on  [gi|1032292087|gb|OAP06414|]
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MYB65 [Arabidopsis thaliana]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 999994)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03091 super family cl33633
hypothetical protein; Provisional
 41-146 5.28e-43

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03091:

Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 159.76  E-value: 5.28e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292087  41 LKKGPWTSTEDGILIDYVKKHGEGNWNAVQKHTSLARCGKSCRLRWANHLRPNLKKGAFSQEEEQLIVEMHAKMGNKWAQ 120
Cdd:PLN03091   12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWSQ 91

                          90       100
                  ....*....|....*....|....*...
gi 1032292087 121 MAEHLPGRTDNEIKNYWNTRIKR--RQR 146
Cdd:PLN03091   92 IAAQLPGRTDNEIKNLWNSCLKKklRQR 119
 
Name Accession Description Interval E-value
PLN03091 PLN03091
hypothetical protein; Provisional
 41-146 5.28e-43

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 159.76  E-value: 5.28e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292087  41 LKKGPWTSTEDGILIDYVKKHGEGNWNAVQKHTSLARCGKSCRLRWANHLRPNLKKGAFSQEEEQLIVEMHAKMGNKWAQ 120
Cdd:PLN03091   12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWSQ 91

                          90       100
                  ....*....|....*....|....*...
gi 1032292087 121 MAEHLPGRTDNEIKNYWNTRIKR--RQR 146
Cdd:PLN03091   92 IAAQLPGRTDNEIKNLWNSCLKKklRQR 119
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 36-144 1.42e-17

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 85.61  E-value: 1.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292087  36 GKRSVLKKGPWTSTEDGILIDYVKKHGEGNWNAVQKHTSLaRCGKSCRLRWANHLRPNLKKGAFSQEEEQLIVEMHAKMG 115
Cdd:COG5147    13 LMQTKRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLIS-STGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELG 91

                          90       100
                  ....*....|....*....|....*....
gi 1032292087 116 NKWAQMAEHLPGRTDNEIKNYWNTRIKRR 144
Cdd:COG5147    92 TQWSTIADYKDRRTAQQCVERYVNTLEDL 120
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 96-139 2.74e-16

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 72.54  E-value: 2.74e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1032292087  96 KGAFSQEEEQLIVEMHAKMGNKWAQMAEHLPGRTDNEIKNYWNT 139
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
96-143 1.74e-13

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 64.94  E-value: 1.74e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1032292087   96 KGAFSQEEEQLIVEMHAKMG-NKWAQMAEHLPGRTDNEIKNYWNTRIKR 143
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 98-139 4.29e-12

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 60.67  E-value: 4.29e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1032292087  98 AFSQEEEQLIVEMHAKMG-NKWAQMAEHLPGRTDNEIKNYWNT 139
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRN 43
 
Name Accession Description Interval E-value
PLN03091 PLN03091
hypothetical protein; Provisional
 41-146 5.28e-43

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 159.76  E-value: 5.28e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292087  41 LKKGPWTSTEDGILIDYVKKHGEGNWNAVQKHTSLARCGKSCRLRWANHLRPNLKKGAFSQEEEQLIVEMHAKMGNKWAQ 120
Cdd:PLN03091   12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWSQ 91

                          90       100
                  ....*....|....*....|....*...
gi 1032292087 121 MAEHLPGRTDNEIKNYWNTRIKR--RQR 146
Cdd:PLN03091   92 IAAQLPGRTDNEIKNLWNSCLKKklRQR 119
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 41-166 8.48e-40

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 145.22  E-value: 8.48e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292087  41 LKKGPWTSTEDGILIDYVKKHGEGNWNAVQKHTSLARCGKSCRLRWANHLRPNLKKGAFSQEEEQLIVEMHAKMGNKWAQ 120
Cdd:PLN03212   23 MKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSL 102

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1032292087 121 MAEHLPGRTDNEIKNYWNTRIKRR-QRAGL-PLYPPEIYVDDLHWSEE 166
Cdd:PLN03212  103 IAGRIPGRTDNEIKNYWNTHLRKKlLRQGIdPQTHKPLDANNIHKPEE 150
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 36-144 1.42e-17

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 85.61  E-value: 1.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292087  36 GKRSVLKKGPWTSTEDGILIDYVKKHGEGNWNAVQKHTSLaRCGKSCRLRWANHLRPNLKKGAFSQEEEQLIVEMHAKMG 115
Cdd:COG5147    13 LMQTKRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLIS-STGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELG 91

                          90       100
                  ....*....|....*....|....*....
gi 1032292087 116 NKWAQMAEHLPGRTDNEIKNYWNTRIKRR 144
Cdd:COG5147    92 TQWSTIADYKDRRTAQQCVERYVNTLEDL 120
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 96-139 2.74e-16

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 72.54  E-value: 2.74e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1032292087  96 KGAFSQEEEQLIVEMHAKMGNKWAQMAEHLPGRTDNEIKNYWNT 139
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
96-143 1.74e-13

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 64.94  E-value: 1.74e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1032292087   96 KGAFSQEEEQLIVEMHAKMG-NKWAQMAEHLPGRTDNEIKNYWNTRIKR 143
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 46-105 2.40e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 61.94  E-value: 2.40e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032292087  46 WTSTEDGILIDYVKKHGeGNWNAVQKHTSlARCGKSCRLRWANHLRPNLKKGAFSQEEEQ 105
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELG-RRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 98-139 4.29e-12

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 60.67  E-value: 4.29e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1032292087  98 AFSQEEEQLIVEMHAKMG-NKWAQMAEHLPGRTDNEIKNYWNT 139
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRN 43
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 43-90 1.66e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 59.05  E-value: 1.66e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1032292087  43 KGPWTSTEDGILIDYVKKHGeGNWNAVQKHTSLaRCGKSCRLRWANHL 90
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPG-RTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
43-92 1.21e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 56.85  E-value: 1.21e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1032292087   43 KGPWTSTEDGILIDYVKKHGEGNWNAVQKHTSLaRCGKSCRLRWANHLRP 92
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPG-RTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 45-90 9.18e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 54.12  E-value: 9.18e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1032292087  45 PWTSTEDGILIDYVKKHGEGNWNAVQKHTSLaRCGKSCRLRWANHL 90
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPG-RTPKQCRERWRNLL 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 99-142 5.49e-07

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 46.53  E-value: 5.49e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1032292087  99 FSQEEEQLIVEMHAKMGNKWAQMAEHLPGRTDNEIKNYWNTRIK 142
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLN 44
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 45-88 1.03e-05

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 42.94  E-value: 1.03e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1032292087  45 PWTSTEDGILIDYVKKHGEGNWNAVQKHTSLA--RCGKSCRLRWAN 88
Cdd:cd11660     2 KWTDEEDEALVEGVEKYGVGNWAKILKDYFFVnnRTSVDLKDKWRN 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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