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Conserved domains on  [gi|1050391861|gb|OCT94052|]
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hypothetical protein XELAEV_18011715mg [Xenopus laevis]

Protein Classification

Somatomedin_B and HX domain-containing protein( domain architecture ID 10470560)

Somatomedin_B and HX domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 63-345 3.60e-34

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 124.73  E-value: 3.60e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050391861  63 KGKYFYELDDKSAlDGYPKLIKDVW-GIDGPVDAAFTRMNcQGKTYLFKGKEYWRFSNGVLESDYPRNISE-GFHDIPDN 140
Cdd:cd00094    23 KGRYFWRLSPGKP-PGSPFLISSFWpSLPSPVDAAFERPD-TGKIYFFKGDKYWVYTGKNLEPGYPKPISDlGFPPTVKQ 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050391861 141 IDAAFALPannhnDREKVYFFKGNKYWQYEFQNQPSRKDCqdsaqselftyyvtlqkdswedffsflfgpsmkrstagPW 220
Cdd:cd00094   101 IDAALRWP-----DNGKTYFFKGDKYWRYDEKTQKMDPGY--------------------------------------PK 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050391861 221 YINKDWKGVPNNVDAVlpsriyvpkqtrrsrrrksrrrnnrkksggmrslwsdfsfdpldglFDYDDEqsdpdwlpperp 300
Cdd:cd00094   138 LIETDFPGVPDKVDAA----------------------------------------------FRWLDG------------ 159

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1050391861 301 adcqptqNVYFFKNDKYYRVNLRTKRVDyvyPPYPRSIAQYWLGC 345
Cdd:cd00094   160 -------YYYFFKGDQYWRFDPRSKEVR---VGYPLKISSDWLGC 194
Somatomedin_B pfam01033
Somatomedin B domain;
24-63 4.31e-12

Somatomedin B domain;


:

Pssm-ID: 460034  Cd Length: 40  Bit Score: 60.01  E-value: 4.31e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1050391861  24 ESCAGRCFSGFDGNKKCQCDIICVHFESCCIDYLTLCKPK 63
Cdd:pfam01033   1 ESCKGRCGESFDRGRLCQCDDDCVKYGDCCPDYESLCLGE 40
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 63-345 3.60e-34

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 124.73  E-value: 3.60e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050391861  63 KGKYFYELDDKSAlDGYPKLIKDVW-GIDGPVDAAFTRMNcQGKTYLFKGKEYWRFSNGVLESDYPRNISE-GFHDIPDN 140
Cdd:cd00094    23 KGRYFWRLSPGKP-PGSPFLISSFWpSLPSPVDAAFERPD-TGKIYFFKGDKYWVYTGKNLEPGYPKPISDlGFPPTVKQ 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050391861 141 IDAAFALPannhnDREKVYFFKGNKYWQYEFQNQPSRKDCqdsaqselftyyvtlqkdswedffsflfgpsmkrstagPW 220
Cdd:cd00094   101 IDAALRWP-----DNGKTYFFKGDKYWRYDEKTQKMDPGY--------------------------------------PK 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050391861 221 YINKDWKGVPNNVDAVlpsriyvpkqtrrsrrrksrrrnnrkksggmrslwsdfsfdpldglFDYDDEqsdpdwlpperp 300
Cdd:cd00094   138 LIETDFPGVPDKVDAA----------------------------------------------FRWLDG------------ 159

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1050391861 301 adcqptqNVYFFKNDKYYRVNLRTKRVDyvyPPYPRSIAQYWLGC 345
Cdd:cd00094   160 -------YYYFFKGDQYWRFDPRSKEVR---VGYPLKISSDWLGC 194
Somatomedin_B pfam01033
Somatomedin B domain;
24-63 4.31e-12

Somatomedin B domain;


Pssm-ID: 460034  Cd Length: 40  Bit Score: 60.01  E-value: 4.31e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1050391861  24 ESCAGRCFSGFDGNKKCQCDIICVHFESCCIDYLTLCKPK 63
Cdd:pfam01033   1 ESCKGRCGESFDRGRLCQCDDDCVKYGDCCPDYESLCLGE 40
SO smart00201
Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from ...
 22-63 3.07e-11

Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from vitronectin, that is a growth hormone-dependent serum factor with protease-inhibiting activity.


Pssm-ID: 197571  Cd Length: 43  Bit Score: 57.77  E-value: 3.07e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1050391861   22 AEESCAGRCFSGFDGNKKCQCDIICVHFESCCIDYLTLCKPK 63
Cdd:smart00201   1 AIGSCKGRCGESFNEGNACRCDALCLSYGDCCTDYESVCKKE 42
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 93-138 5.48e-09

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 51.47  E-value: 5.48e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1050391861   93 VDAAFTRMNcqGKTYLFKGKEYWRFSNGVLESDYPRNISEGFHDIP 138
Cdd:smart00120   1 IDAAFELRD--GKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 93-132 1.04e-07

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 47.56  E-value: 1.04e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1050391861  93 VDAAFTRMNcqGKTYLFKGKEYWRFSNGVLESDYPRNISE 132
Cdd:pfam00045   1 IDAAFEDRD--GKTYFFKGRKYWRFDPQRVEPGYPKLISD 38
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 63-345 3.60e-34

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 124.73  E-value: 3.60e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050391861  63 KGKYFYELDDKSAlDGYPKLIKDVW-GIDGPVDAAFTRMNcQGKTYLFKGKEYWRFSNGVLESDYPRNISE-GFHDIPDN 140
Cdd:cd00094    23 KGRYFWRLSPGKP-PGSPFLISSFWpSLPSPVDAAFERPD-TGKIYFFKGDKYWVYTGKNLEPGYPKPISDlGFPPTVKQ 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050391861 141 IDAAFALPannhnDREKVYFFKGNKYWQYEFQNQPSRKDCqdsaqselftyyvtlqkdswedffsflfgpsmkrstagPW 220
Cdd:cd00094   101 IDAALRWP-----DNGKTYFFKGDKYWRYDEKTQKMDPGY--------------------------------------PK 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050391861 221 YINKDWKGVPNNVDAVlpsriyvpkqtrrsrrrksrrrnnrkksggmrslwsdfsfdpldglFDYDDEqsdpdwlpperp 300
Cdd:cd00094   138 LIETDFPGVPDKVDAA----------------------------------------------FRWLDG------------ 159

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1050391861 301 adcqptqNVYFFKNDKYYRVNLRTKRVDyvyPPYPRSIAQYWLGC 345
Cdd:cd00094   160 -------YYYFFKGDQYWRFDPRSKEVR---VGYPLKISSDWLGC 194
Somatomedin_B pfam01033
Somatomedin B domain;
24-63 4.31e-12

Somatomedin B domain;


Pssm-ID: 460034  Cd Length: 40  Bit Score: 60.01  E-value: 4.31e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1050391861  24 ESCAGRCFSGFDGNKKCQCDIICVHFESCCIDYLTLCKPK 63
Cdd:pfam01033   1 ESCKGRCGESFDRGRLCQCDDDCVKYGDCCPDYESLCLGE 40
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 96-344 1.57e-11

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 62.71  E-value: 1.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050391861  96 AFTRMNcqGKTYLFKGKEYWRFSNGVLEsDYPRNISEGFHDIPDNIDAAFalpanNHNDREKVYFFKGNKYWQYEFQNqp 175
Cdd:cd00094    11 AVTTLR--GELYFFKGRYFWRLSPGKPP-GSPFLISSFWPSLPSPVDAAF-----ERPDTGKIYFFKGDKYWVYTGKN-- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050391861 176 srkdcqdsaqselftyyvtLQKDSWEDFFSFLFGPSmkrstagpwyinkdwkgvPNNVDAVLPsriyvpkqtrrsrrrks 255
Cdd:cd00094    81 -------------------LEPGYPKPISDLGFPPT------------------VKQIDAALR----------------- 106

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1050391861 256 rrrnnrkksggmrslwsdfsfdpldglfdyddeqsdpdwlpperpadCQPTQNVYFFKNDKYYRVNLRTKRVDyvyPPYP 335
Cdd:cd00094   107 -----------------------------------------------WPDNGKTYFFKGDKYWRYDEKTQKMD---PGYP 136


                  ....*....
gi 1050391861 336 RSIAQYWLG 344
Cdd:cd00094   137 KLIETDFPG 145
SO smart00201
Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from ...
 22-63 3.07e-11

Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from vitronectin, that is a growth hormone-dependent serum factor with protease-inhibiting activity.


Pssm-ID: 197571  Cd Length: 43  Bit Score: 57.77  E-value: 3.07e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1050391861   22 AEESCAGRCFSGFDGNKKCQCDIICVHFESCCIDYLTLCKPK 63
Cdd:smart00201   1 AIGSCKGRCGESFNEGNACRCDALCLSYGDCCTDYESVCKKE 42
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 93-138 5.48e-09

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 51.47  E-value: 5.48e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1050391861   93 VDAAFTRMNcqGKTYLFKGKEYWRFSNGVLESDYPRNISEGFHDIP 138
Cdd:smart00120   1 IDAAFELRD--GKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 93-132 1.04e-07

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 47.56  E-value: 1.04e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1050391861  93 VDAAFTRMNcqGKTYLFKGKEYWRFSNGVLESDYPRNISE 132
Cdd:pfam00045   1 IDAAFEDRD--GKTYFFKGRKYWRFDPQRVEPGYPKLISD 38
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 141-173 4.22e-04

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 37.61  E-value: 4.22e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1050391861  141 IDAAFALPannhndREKVYFFKGNKYWQYEFQN 173
Cdd:smart00120   1 IDAAFELR------DGKTYFFKGDKYWRFDPKR 27
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 141-175 2.44e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 35.23  E-value: 2.44e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1050391861 141 IDAAFALPANnhndreKVYFFKGNKYWQYEFQNQP 175
Cdd:pfam00045   1 IDAAFEDRDG------KTYFFKGRKYWRFDPQRVE 29
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 309-344 4.19e-03

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 34.91  E-value: 4.19e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1050391861  309 VYFFKNDKYYRVNLRTKRvdyvyPPYPRSIAQYWLG 344
Cdd:smart00120  12 TYFFKGDKYWRFDPKRVD-----PGYPKLISSFFPG 42
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 309-345 7.21e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 34.08  E-value: 7.21e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1050391861 309 VYFFKNDKYYRVNLRTKRvdyvyPPYPRSIAQY-WLGC 345
Cdd:pfam00045  12 TYFFKGRKYWRFDPQRVE-----PGYPKLISDFpGLPC 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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