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Conserved domains on  [gi|1065008553|gb|ODV96819|]
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hypothetical protein PACTADRAFT_48629 [Pachysolen tannophilus NRRL Y-2460]

Protein Classification

cyclin family protein( domain architecture ID 15334629)

cyclin family protein may associate with and activate its cognate cyclin-dependent kinase (CDK); similar to Saccharomyces cerevisiae PHO85 cyclin-10 and Neurospora crassa Nuc-1 negative regulatory protein preg

CATH:  1.10.472.10
Gene Ontology:  GO:0000079|GO:0019901
PubMed:  30185601
SCOP:  4001102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_ScPCL7-like cd20558
cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ...
 184-304 6.42e-29

cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ScPCL7, also called PHO85-associated protein 1, is a cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL6, ScPCL7 controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. This family also includes Schizosaccharomyces pombe PHO85 cyclin-like protein Psl1 (SpPsl1) and Arabidopsis thaliana PHO80-like proteins, P-type cyclins (CYCPs). SpPsl1 is the cyclin partner of the CDK pef1 (PHO85 homolog). CYCPs may be involved in cell division, cell differentiation, and the nutritional status of the cell in Arabidopsis thaliana. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


:

Pssm-ID: 410261  Cd Length: 101  Bit Score: 106.87  E-value: 6.42e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1065008553 184 PSLSIVAYLERIFKYGELSTGVILTASIFLFSVIFNINYkldyhrestininspakirpLPVNKFNIFRIVLTVIRVALK 263
Cdd:cd20558     1 PSISILDYLERIVKYCPCSPECFLLALIYIDRLIATING--------------------FVVTSLNVHRLLITALTLAAK 60

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1065008553 264 LIEDKNFKQSYYCKITGLeSNSDLFKLELNLLFLTDFNLFI 304
Cdd:cd20558    61 FLDDRYYSNAYYAKVGGV-SVSELNKLELEFLFLLDFDLHV 100
 
Name Accession Description Interval E-value
CYCLIN_ScPCL7-like cd20558
cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ...
 184-304 6.42e-29

cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ScPCL7, also called PHO85-associated protein 1, is a cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL6, ScPCL7 controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. This family also includes Schizosaccharomyces pombe PHO85 cyclin-like protein Psl1 (SpPsl1) and Arabidopsis thaliana PHO80-like proteins, P-type cyclins (CYCPs). SpPsl1 is the cyclin partner of the CDK pef1 (PHO85 homolog). CYCPs may be involved in cell division, cell differentiation, and the nutritional status of the cell in Arabidopsis thaliana. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410261  Cd Length: 101  Bit Score: 106.87  E-value: 6.42e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1065008553 184 PSLSIVAYLERIFKYGELSTGVILTASIFLFSVIFNINYkldyhrestininspakirpLPVNKFNIFRIVLTVIRVALK 263
Cdd:cd20558     1 PSISILDYLERIVKYCPCSPECFLLALIYIDRLIATING--------------------FVVTSLNVHRLLITALTLAAK 60

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1065008553 264 LIEDKNFKQSYYCKITGLeSNSDLFKLELNLLFLTDFNLFI 304
Cdd:cd20558    61 FLDDRYYSNAYYAKVGGV-SVSELNKLELEFLFLLDFDLHV 100
Cyclin pfam08613
Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific ...
 173-302 1.53e-17

Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific cyclin pas1, and the phosphate system cyclin PHO80/PHO85.


Pssm-ID: 400780  Cd Length: 149  Bit Score: 78.26  E-value: 1.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1065008553 173 GLIKKFYLKEIPSLSIVAYLERIFKYGELSTGVILTASIFLFSVIFNINYKLdyhrestininspakirpLPVNKFNIFR 252
Cdd:pfam08613  39 SPELSFYSKAVPAISIGAYLSRIQKFCPSSPAVLLSALIYLDRLVKRCDSEA------------------FVVTSANAHR 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1065008553 253 IVLTVIRVALKLIEDKNFKQSYYCKITGLeSNSDLFKLELNLLFLTDFNL 302
Cdd:pfam08613 101 LLITAVTVATKFLSDGFYSNSRFAKVGGI-SLHELNHLEIDFLFLVDFDL 149
 
Name Accession Description Interval E-value
CYCLIN_ScPCL7-like cd20558
cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ...
 184-304 6.42e-29

cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ScPCL7, also called PHO85-associated protein 1, is a cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL6, ScPCL7 controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. This family also includes Schizosaccharomyces pombe PHO85 cyclin-like protein Psl1 (SpPsl1) and Arabidopsis thaliana PHO80-like proteins, P-type cyclins (CYCPs). SpPsl1 is the cyclin partner of the CDK pef1 (PHO85 homolog). CYCPs may be involved in cell division, cell differentiation, and the nutritional status of the cell in Arabidopsis thaliana. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410261  Cd Length: 101  Bit Score: 106.87  E-value: 6.42e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1065008553 184 PSLSIVAYLERIFKYGELSTGVILTASIFLFSVIFNINYkldyhrestininspakirpLPVNKFNIFRIVLTVIRVALK 263
Cdd:cd20558     1 PSISILDYLERIVKYCPCSPECFLLALIYIDRLIATING--------------------FVVTSLNVHRLLITALTLAAK 60

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1065008553 264 LIEDKNFKQSYYCKITGLeSNSDLFKLELNLLFLTDFNLFI 304
Cdd:cd20558    61 FLDDRYYSNAYYAKVGGV-SVSELNKLELEFLFLLDFDLHV 100
CYCLIN_AtCycU-like cd20604
cyclin box found in Arabidopsis thaliana U-type cyclins (CycUs) and similar proteins; CycUs ...
 178-305 9.29e-18

cyclin box found in Arabidopsis thaliana U-type cyclins (CycUs) and similar proteins; CycUs interact with cyclin-dependent kinase A-1 (CDKA-1) to trigger its kinase activity. CycUs contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410307  Cd Length: 126  Bit Score: 78.20  E-value: 9.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1065008553 178 FYLKEIPSLSIVAYLERIFKYGELSTGVILTASIFLFSVIfninykldyHREstininspakiRPLPVNKFNIFRIVLTV 257
Cdd:cd20604     5 FHGVRAPSISIASYLERIFKYTNCSPSCFVVAYVYIDRFI---------HKQ-----------PGLPISSLNVHRLLITS 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1065008553 258 IRVALKLIEDKNFKQSYYCKITGLeSNSDLFKLELNLLFLTDFNLFIN 305
Cdd:cd20604    65 VMVAAKFLDDLYYNNAYYAKVGGV-STEELNRLELEFLFLLDFKLNVT 111
Cyclin pfam08613
Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific ...
 173-302 1.53e-17

Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific cyclin pas1, and the phosphate system cyclin PHO80/PHO85.


Pssm-ID: 400780  Cd Length: 149  Bit Score: 78.26  E-value: 1.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1065008553 173 GLIKKFYLKEIPSLSIVAYLERIFKYGELSTGVILTASIFLFSVIFNINYKLdyhrestininspakirpLPVNKFNIFR 252
Cdd:pfam08613  39 SPELSFYSKAVPAISIGAYLSRIQKFCPSSPAVLLSALIYLDRLVKRCDSEA------------------FVVTSANAHR 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1065008553 253 IVLTVIRVALKLIEDKNFKQSYYCKITGLeSNSDLFKLELNLLFLTDFNL 302
Cdd:pfam08613 101 LLITAVTVATKFLSDGFYSNSRFAKVGGI-SLHELNHLEIDFLFLVDFDL 149
CYCLIN_ScPCL1-like cd20557
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar ...
 187-300 7.17e-03

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; The family includes a group of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase, such as Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2, PCL9 and their vertebrate counterparts, cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1). PCL1 (also called PHO85 cyclin-1, or cyclin HCS26) and PCL2 (also called PHO85 cyclin-1, or cyclin HCS26 homolog) are G1/S-specific cyclin partners of the cyclin-dependent kinase (CDK) PHO85. They are essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, it positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton. PCL9 is an M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. It may have a role in bud site selection in the G1 phase. The family also includes cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1) and similar proteins. Their biological functions remain unclear. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410260  Cd Length: 94  Bit Score: 35.33  E-value: 7.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1065008553 187 SIVAYLERIFKYGELSTGVILTAsIFLFSVIFNINYKLDYHREstininspakirplpvnkFNIFRIVLTVIRVALKLIE 266
Cdd:cd20557     1 SLRSFIARLLRRTRLSPSVVLLA-LVYLERLRRRLPEALLGQE------------------GSPYRLFLVALMLASKYLD 61

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1065008553 267 DKNFKQSYYCKITGLESnSDLFKLELNLLFLTDF 300
Cdd:cd20557    62 DESYSNKSWAEISGLPV-RELNAMEREFLEALDW 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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