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Conserved domains on  [gi|1067546604|gb|OEG08303|]
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AraC family transcriptional regulator [Aeromonas caviae]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12820790)

AraC family transcriptional regulator containing an AraC family helix-turn-helix (HTH) domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|15808743|9409145|33837749|11282467

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlxA super family cl34854
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 146-247 3.01e-27

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


The actual alignment was detected with superfamily member COG4977:

Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 106.78  E-value: 3.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604 146 PRIAKVQRHMEAHLADPLTNEELAAIACLGLSQFKHAFRQQVGTSVSHYLRMRRMALARTLLARTRLPVGEVASRCGYQN 225
Cdd:COG4977   210 PRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGS 289

                          90       100
                  ....*....|....*....|..
gi 1067546604 226 QGAFAERFLAETGLTPSLWRRQ 247
Cdd:COG4977   290 ASHFRRAFRRRFGVSPSAYRRR 311
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
16-248 4.78e-23

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 94.46  E-value: 4.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604  16 FSLRHYQSDMQSHSHDHAQLVIPLVGPLEIEVQGRGCRLAPGFACIIAPGLRHDYAADPAHVFLVQESHWLPAALGDHPF 95
Cdd:COG2207    24 LLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604  96 VELDEAQRHYLAFLHRMVAEGRHVAGMDQVWLGLLTEGRGMGPAVAPRIAPRIAKVQRHMEAHLAdpLTNEELAAIACLG 175
Cdd:COG2207   104 LLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL--LTLEELARELGLS 181

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1067546604 176 LSQFKHAFRQQVGTSVSHYLRMRRMALARTLLARTRLPVGEVASRCGYQNQGAFAERFLAETGLTPSLWRRQN 248
Cdd:COG2207   182 PRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRL 254
 
Name Accession Description Interval E-value
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 146-247 3.01e-27

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 106.78  E-value: 3.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604 146 PRIAKVQRHMEAHLADPLTNEELAAIACLGLSQFKHAFRQQVGTSVSHYLRMRRMALARTLLARTRLPVGEVASRCGYQN 225
Cdd:COG4977   210 PRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGS 289

                          90       100
                  ....*....|....*....|..
gi 1067546604 226 QGAFAERFLAETGLTPSLWRRQ 247
Cdd:COG4977   290 ASHFRRAFRRRFGVSPSAYRRR 311
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
162-245 9.08e-24

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 91.08  E-value: 9.08e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604  162 PLTNEELAAIACLGLSQFKHAFRQQVGTSVSHYLRMRRMALARTLLARTRLPVGEVASRCGYQNQGAFAERFLAETGLTP 241
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 1067546604  242 SLWR 245
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
16-248 4.78e-23

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 94.46  E-value: 4.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604  16 FSLRHYQSDMQSHSHDHAQLVIPLVGPLEIEVQGRGCRLAPGFACIIAPGLRHDYAADPAHVFLVQESHWLPAALGDHPF 95
Cdd:COG2207    24 LLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604  96 VELDEAQRHYLAFLHRMVAEGRHVAGMDQVWLGLLTEGRGMGPAVAPRIAPRIAKVQRHMEAHLAdpLTNEELAAIACLG 175
Cdd:COG2207   104 LLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL--LTLEELARELGLS 181

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1067546604 176 LSQFKHAFRQQVGTSVSHYLRMRRMALARTLLARTRLPVGEVASRCGYQNQGAFAERFLAETGLTPSLWRRQN 248
Cdd:COG2207   182 PRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRL 254
HTH_18 pfam12833
Helix-turn-helix domain;
168-247 2.32e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 82.25  E-value: 2.32e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604 168 LAAIACLGLSQFKHAFRQQVGTSVSHYLRMRRMALARTLLAR-TRLPVGEVASRCGYQNQGAFAERFLAETGLTPSLWRR 246
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 1067546604 247 Q 247
Cdd:pfam12833  81 R 81
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
155-247 1.57e-15

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 74.17  E-value: 1.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604 155 MEAHLADPLTNEELAAIaC----LGLSQFKHAFRQQVGTSVSHYLRMRRMALARTLLARTRLPVGEVASRCGYQNQGAFA 230
Cdd:PRK13501  182 MSALQQSLGAYFDMADF-ChknqLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFS 260

                          90
                  ....*....|....*..
gi 1067546604 231 ERFLAETGLTPSLWRRQ 247
Cdd:PRK13501  261 AVFTREAGMTPRDYRQR 277
cupin_YobQ-like_N cd07003
Bacillus subtilis YobQ and related proteins, N-terminal cupin domain; This family includes ...
 19-80 5.03e-14

Bacillus subtilis YobQ and related proteins, N-terminal cupin domain; This family includes bacterial proteins homologous to Bacillus subtilis YobQ and Photobacterium leiognathi LumQ, both uncharacterized proteins thought to be DNA-binding proteins that may function as AraC/XylS family transcriptional regulators. YobQ has an N-terminal cupin beta barrel domain (represented by this alignment model) and a C-terminal AraC/XylS family helix-turn-helix (HTH) DNA-binding domain. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380407 [Multi-domain]  Cd Length: 66  Bit Score: 65.11  E-value: 5.03e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1067546604  19 RHYQSDMQSHSHDHAQLVIPLVGPLEIEVQGRGCRLAPGFACIIAPGLRHDYAADPAHVFLV 80
Cdd:cd07003     1 RTYSHDQSSHSHEHAQLVLPLSGSLELEVEGRGSRVKPDIGLYIPPNAEHRFAGSSDNRCLV 62
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
19-248 6.88e-14

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 69.75  E-value: 6.88e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604  19 RHYQSDMQSHSHDHAQLVIPLVGPLEIEVQGRGCRLAPGFACIIAPGLRHDYAAdpAHVFLVQESHWLPAAL-------G 91
Cdd:PRK13500   55 RYPQDVFAEHTHDFCELVIVWRGNGLHVLNDRPYRITRGDLFYIHADDKHSYAS--VNDLVLQNIIYCPERLklnldwqG 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604  92 DHPFVELDEAQRHYLAFLHRMvAEGRHVAG---------------MDQVWLG----LLTEGRGMGPAVAPRIAPRIA-KV 151
Cdd:PRK13500  133 AIPGFSASAGQPHWRLGSVGM-AQARQVIGqlehessqhvpfaneMAELLFGqlvmLLNRHRYTSDSLPPTSSETLLdKL 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604 152 QRHMEAHLADPLTNEELAAIACLGLSQFKHAFRQQVGTSVSHYLRMRRMALARTLLARTRLPVGEVASRCGYQNQGAFAE 231
Cdd:PRK13500  212 ITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSV 291

                         250
                  ....*....|....*..
gi 1067546604 232 RFLAETGLTPSLWRRQN 248
Cdd:PRK13500  292 VFTRETGMTPSQWRHLN 308
 
Name Accession Description Interval E-value
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 146-247 3.01e-27

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 106.78  E-value: 3.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604 146 PRIAKVQRHMEAHLADPLTNEELAAIACLGLSQFKHAFRQQVGTSVSHYLRMRRMALARTLLARTRLPVGEVASRCGYQN 225
Cdd:COG4977   210 PRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGS 289

                          90       100
                  ....*....|....*....|..
gi 1067546604 226 QGAFAERFLAETGLTPSLWRRQ 247
Cdd:COG4977   290 ASHFRRAFRRRFGVSPSAYRRR 311
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
162-245 9.08e-24

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 91.08  E-value: 9.08e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604  162 PLTNEELAAIACLGLSQFKHAFRQQVGTSVSHYLRMRRMALARTLLARTRLPVGEVASRCGYQNQGAFAERFLAETGLTP 241
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 1067546604  242 SLWR 245
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
16-248 4.78e-23

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 94.46  E-value: 4.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604  16 FSLRHYQSDMQSHSHDHAQLVIPLVGPLEIEVQGRGCRLAPGFACIIAPGLRHDYAADPAHVFLVQESHWLPAALGDHPF 95
Cdd:COG2207    24 LLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604  96 VELDEAQRHYLAFLHRMVAEGRHVAGMDQVWLGLLTEGRGMGPAVAPRIAPRIAKVQRHMEAHLAdpLTNEELAAIACLG 175
Cdd:COG2207   104 LLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL--LTLEELARELGLS 181

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1067546604 176 LSQFKHAFRQQVGTSVSHYLRMRRMALARTLLARTRLPVGEVASRCGYQNQGAFAERFLAETGLTPSLWRRQN 248
Cdd:COG2207   182 PRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRL 254
HTH_18 pfam12833
Helix-turn-helix domain;
168-247 2.32e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 82.25  E-value: 2.32e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604 168 LAAIACLGLSQFKHAFRQQVGTSVSHYLRMRRMALARTLLAR-TRLPVGEVASRCGYQNQGAFAERFLAETGLTPSLWRR 246
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 1067546604 247 Q 247
Cdd:pfam12833  81 R 81
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 134-247 1.05e-15

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 75.48  E-value: 1.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604 134 RGMGPAVAPRIAPRIAKVQRHMEAHLADPLTNEELAAIACLGLSQFKHAFRQQVGTSVSHYLRMRRMALARTLLaRTRLP 213
Cdd:COG2169    72 RPDLAPGSPPRADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLL-QTGLS 150

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1067546604 214 VGEVASRCGYQNQGAFAERFLAETGLTPSLWRRQ 247
Cdd:COG2169   151 VTDAAYAAGFGSLSRFYEAFKKLLGMTPSAYRRG 184
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
155-247 1.57e-15

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 74.17  E-value: 1.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604 155 MEAHLADPLTNEELAAIaC----LGLSQFKHAFRQQVGTSVSHYLRMRRMALARTLLARTRLPVGEVASRCGYQNQGAFA 230
Cdd:PRK13501  182 MSALQQSLGAYFDMADF-ChknqLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFS 260

                          90
                  ....*....|....*..
gi 1067546604 231 ERFLAETGLTPSLWRRQ 247
Cdd:PRK13501  261 AVFTREAGMTPRDYRQR 277
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
142-252 2.16e-15

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 73.85  E-value: 2.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604 142 PRIAPRIAKVQRHMEAHLADPLTNEELAAIACLGLSQFKHAFRQQVGTSVshyLRMR---RMALARTLLARTRLPVGEVA 218
Cdd:PRK10572  179 PPMDPRVREACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISV---LRWRedqRISRAKLLLQTTRMPIATIG 255

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1067546604 219 SRCGYQNQGAFAERFLAETGLTPSLWRRQNGCLP 252
Cdd:PRK10572  256 RNVGYDDQLYFSRVFKKCTGASPSEFRARCEEKN 289
cupin_YobQ-like_N cd07003
Bacillus subtilis YobQ and related proteins, N-terminal cupin domain; This family includes ...
 19-80 5.03e-14

Bacillus subtilis YobQ and related proteins, N-terminal cupin domain; This family includes bacterial proteins homologous to Bacillus subtilis YobQ and Photobacterium leiognathi LumQ, both uncharacterized proteins thought to be DNA-binding proteins that may function as AraC/XylS family transcriptional regulators. YobQ has an N-terminal cupin beta barrel domain (represented by this alignment model) and a C-terminal AraC/XylS family helix-turn-helix (HTH) DNA-binding domain. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380407 [Multi-domain]  Cd Length: 66  Bit Score: 65.11  E-value: 5.03e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1067546604  19 RHYQSDMQSHSHDHAQLVIPLVGPLEIEVQGRGCRLAPGFACIIAPGLRHDYAADPAHVFLV 80
Cdd:cd07003     1 RTYSHDQSSHSHEHAQLVLPLSGSLELEVEGRGSRVKPDIGLYIPPNAEHRFAGSSDNRCLV 62
ftrA PRK09393
transcriptional activator FtrA; Provisional
 140-249 5.88e-14

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 69.99  E-value: 5.88e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604 140 VAPRIAPRIAKVQRHMEAHLADPLTNEELAAIACLGLSQFKHAFRQQVGTSVSHYLRMRRMALARTLLARTRLPVGEVAS 219
Cdd:PRK09393  212 VASRESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAE 291

                          90       100       110
                  ....*....|....*....|....*....|
gi 1067546604 220 RCGYQNQGAFAERFLAETGLTPSLWRRQNG 249
Cdd:PRK09393  292 RAGFGSEESLRHHFRRRAATSPAAYRKRFG 321
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
19-248 6.88e-14

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 69.75  E-value: 6.88e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604  19 RHYQSDMQSHSHDHAQLVIPLVGPLEIEVQGRGCRLAPGFACIIAPGLRHDYAAdpAHVFLVQESHWLPAAL-------G 91
Cdd:PRK13500   55 RYPQDVFAEHTHDFCELVIVWRGNGLHVLNDRPYRITRGDLFYIHADDKHSYAS--VNDLVLQNIIYCPERLklnldwqG 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604  92 DHPFVELDEAQRHYLAFLHRMvAEGRHVAG---------------MDQVWLG----LLTEGRGMGPAVAPRIAPRIA-KV 151
Cdd:PRK13500  133 AIPGFSASAGQPHWRLGSVGM-AQARQVIGqlehessqhvpfaneMAELLFGqlvmLLNRHRYTSDSLPPTSSETLLdKL 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604 152 QRHMEAHLADPLTNEELAAIACLGLSQFKHAFRQQVGTSVSHYLRMRRMALARTLLARTRLPVGEVASRCGYQNQGAFAE 231
Cdd:PRK13500  212 ITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSV 291

                         250
                  ....*....|....*..
gi 1067546604 232 RFLAETGLTPSLWRRQN 248
Cdd:PRK13500  292 VFTRETGMTPSQWRHLN 308
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
179-245 4.41e-13

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 67.39  E-value: 4.41e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1067546604 179 FKHAFRQQVGTSVSHYLRMRRMALARTLLARTRLPVGEVASRCGYQNQGAFAERFLAETGLTPSLWR 245
Cdd:PRK13502  209 LRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMTPSQWR 275
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
155-247 4.89e-08

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 49.92  E-value: 4.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604 155 MEAHLADPLTNEELAAIACLGLSQFKHAFRQQVGTSVSHYLRMRRMALARTLLARTRLPVGEVASRCGYQNQGAFAERFL 234
Cdd:PRK10219   14 IDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFR 93

                          90
                  ....*....|...
gi 1067546604 235 AETGLTPSLWRRQ 247
Cdd:PRK10219   94 RQFDRTPSDYRHR 106
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 155-196 1.61e-04

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 38.29  E-value: 1.61e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1067546604 155 MEAHLADPLTNEELAAIACLGLSQFKHAFRQQVGTSVSHYLR 196
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
155-248 1.99e-04

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 40.09  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604 155 MEAHLADPLTNEELAAIACLGLSQFKHAFRQQVGTSVSHYLRMRRMALARTLLARTRLPVGEVASRCGYQNQGAFAERFL 234
Cdd:PRK11511   18 IEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTLTRTFK 97

                          90
                  ....*....|....
gi 1067546604 235 AETGLTPSLWRRQN 248
Cdd:PRK11511   98 NYFDVPPHKYRMTN 111
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 210-246 3.96e-04

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 37.13  E-value: 3.96e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1067546604 210 TRLPVGEVASRCGYqNQGAFAERFLAETGLTPSLWRR 246
Cdd:pfam00165   7 TNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
23-74 8.24e-04

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 37.91  E-value: 8.24e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1067546604  23 SDMQSHSHDHAQLVIPLVGPLEIEVQGRGCRLAPGFACIIAPGLRHDYAADP 74
Cdd:COG1917    34 ARTPWHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAFRNLG 85
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
155-247 2.73e-03

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 38.12  E-value: 2.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604 155 MEAHLADPLTNEELAAIACLGLSQFKHAFRQQVGTSVSHYLRMRRMALARTLLARTRLPVGEVASRCGYQNQGAFAERFL 234
Cdd:PRK13503  180 LEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFR 259

                          90
                  ....*....|...
gi 1067546604 235 AETGLTPSLWRRQ 247
Cdd:PRK13503  260 REFSWSPRDIRQG 272
PRK15121 PRK15121
MDR efflux pump AcrAB transcriptional activator RobA;
155-246 2.81e-03

MDR efflux pump AcrAB transcriptional activator RobA;


Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 38.07  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067546604 155 MEAHLADPLTNEELAAIAclGLSQF--KHAFRQQVGTSVSHYLRMRRMALARTLLARTRLPVGEVASRCGYQNQGAFAER 232
Cdd:PRK15121   14 LEGHLDQPLSLDNVAAKA--GYSKWhlQRMFKDVTGHAIGAYIRARRLSKAAVALRLTSRPILDIALQYRFDSQQTFTRA 91

                          90
                  ....*....|....
gi 1067546604 233 FLAETGLTPSLWRR 246
Cdd:PRK15121   92 FKKQFAQTPALYRR 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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