NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1069051796|gb|OEH15353|]
View 

uridine kinase [Enterobacter asburiae]

Protein Classification

uridine-cytidine kinase( domain architecture ID 10792545)

uridine kinase, or uridine cytidine kinase, catalyzes the ATP-dependent phosphorylation of uridine or cytidine to yield UMP or CMP

EC:  2.7.1.48
Gene Ontology:  GO:0005737|GO:0044206|GO:0005829|GO:0016310|GO:0043771|GO:0005524|GO:0004849|GO:0044211
PubMed:  27239701

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 3-213 2.51e-147

uridine/cytidine kinase; Provisional


:

Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 408.01  E-value: 2.51e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796   3 DKSHQCVIIGIAGASASGKSLIASTLYRELreqvGDEHIGVIPEDSYYKDQSHLSMEERVKTNYDHPNAMDHSLLFQHLE 82
Cdd:PRK05480    1 MMMKKPIIIGIAGGSGSGKTTVASTIYEEL----GDESIAVIPQDSYYKDQSHLSFEERVKTNYDHPDAFDHDLLIEHLK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  83 ALKSGQAIELPVYSYVEHTRTQETIRIEPKKVIILEGILLLTDARLRESMNFSIFVDTPLDICLMRRIKRDVNERGRSMD 162
Cdd:PRK05480   77 ALKAGKAIEIPVYDYTEHTRSKETIRVEPKDVIILEGILLLEDERLRDLMDIKIFVDTPLDIRLIRRLKRDVNERGRSLE 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1069051796 163 SVMAQYQKTVRPMFLQFIEPSKQYADIIVPRGGKNRIAIDILKAKISQFFE 213
Cdd:PRK05480  157 SVINQYLSTVRPMHLQFIEPSKRYADIIIPEGGKNRVAIDILKAKIRQLLE 207
 
Name Accession Description Interval E-value
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 3-213 2.51e-147

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 408.01  E-value: 2.51e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796   3 DKSHQCVIIGIAGASASGKSLIASTLYRELreqvGDEHIGVIPEDSYYKDQSHLSMEERVKTNYDHPNAMDHSLLFQHLE 82
Cdd:PRK05480    1 MMMKKPIIIGIAGGSGSGKTTVASTIYEEL----GDESIAVIPQDSYYKDQSHLSFEERVKTNYDHPDAFDHDLLIEHLK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  83 ALKSGQAIELPVYSYVEHTRTQETIRIEPKKVIILEGILLLTDARLRESMNFSIFVDTPLDICLMRRIKRDVNERGRSMD 162
Cdd:PRK05480   77 ALKAGKAIEIPVYDYTEHTRSKETIRVEPKDVIILEGILLLEDERLRDLMDIKIFVDTPLDIRLIRRLKRDVNERGRSLE 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1069051796 163 SVMAQYQKTVRPMFLQFIEPSKQYADIIVPRGGKNRIAIDILKAKISQFFE 213
Cdd:PRK05480  157 SVINQYLSTVRPMHLQFIEPSKRYADIIIPEGGKNRVAIDILKAKIRQLLE 207
udk TIGR00235
uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in ...
 1-213 2.59e-118

uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in phosphoribulokinase hits at scores of 160 and below [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 272977  Cd Length: 207  Bit Score: 334.74  E-value: 2.59e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796   1 MTDKShqCVIIGIAGASASGKSliasTLYRELREQVGDEHIGVIPEDSYYKDQSHLSMEERVKTNYDHPNAMDHSLLFQH 80
Cdd:TIGR00235   1 MDKPK--GIIIGIGGGSGSGKT----TVARKIYEQLGKLEIVIISQDNYYKDQSHLEMAERKKTNFDHPDAFDNDLLYEH 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  81 LEALKSGQAIELPVYSYVEHTRTQETIRIEPKKVIILEGILLLTDARLRESMNFSIFVDTPLDICLMRRIKRDVNERGRS 160
Cdd:TIGR00235  75 LKNLKNGSPIDVPVYDYVNHTRPKETVHIEPKDVVILEGIMPLFDERLRDLMDLKIFVDTPLDIRLIRRIERDINERGRS 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1069051796 161 MDSVMAQYQKTVRPMFLQFIEPSKQYADIIVPRGGKNRIAIDILKAKISQFFE 213
Cdd:TIGR00235 155 LDSVIDQYRKTVRPMYEQFVEPTKQYADLIIPEGGRNEVAINVLDTKIKHLLE 207
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 10-208 1.60e-102

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 294.46  E-value: 1.60e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  10 IIGIAGASASGKSliasTLYRELREQVGDEHIGVIPEDSYYKDQSHLSMEERVKTNYDHPNAMDHSLLFQHLEALKSGQA 89
Cdd:cd02023     1 IIGIAGGSGSGKT----TVAEEIIEQLGNPKVVIISQDSYYKDLSHEELEERKNNNYDHPDAFDFDLLISHLQDLKNGKS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  90 IELPVYSYVEHTRTQETIRIEPKKVIILEGILLLTDARLRESMNFSIFVDTPLDICLMRRIKRDVNERGRSMDSVMAQYQ 169
Cdd:cd02023    77 VEIPVYDFKTHSRLKETVTVYPADVIILEGILALYDKELRDLMDLKIFVDTDADVRLIRRIERDIVERGRDLESVINQYL 156

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1069051796 170 KTVRPMFLQFIEPSKQYADIIVPRGGKNRIAIDILKAKI 208
Cdd:cd02023   157 KFVKPMHEQFIEPTKRYADVIIPRGGDNHVAIDLIVQHI 195
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 2-210 9.99e-100

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 287.51  E-value: 9.99e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796   2 TDKSHQCVIIGIAGASASGKSLIAstlyRELREQVGDEHIGVIPEDSYYKDQSHLSMEERVKTNYDHPNAMDHSLLFQHL 81
Cdd:COG0572     1 AARSGKPRIIGIAGPSGSGKTTFA----RRLAEQLGADKVVVISLDDYYKDREHLPLDERGKPNFDHPEAFDLDLLNEHL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  82 EALKSGQAIELPVYSYVEHTRTQETIRIEPKKVIILEGILLLTDARLRESMNFSIFVDTPLDICLMRRIKRDVNERGRSM 161
Cdd:COG0572    77 EPLKAGESVELPVYDFATGTRSGETVKVEPADVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRRIVRDGEERGRTA 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1069051796 162 DSVMAQYQKTVRPMFLQFIEPSKQYADIIVPRGG-KNRIAIDILKAKISQ 210
Cdd:COG0572   157 ESVIEQYWATVRPGHEQYIEPTKEYADIVIPNGGpLNPVALDLLVARLLS 206
PRK pfam00485
Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop ...
 10-200 1.04e-50

Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop containing kinases: phosphoribulokinases, uridine kinases and bacterial pantothenate kinases(CoaA). Arabidopsis and other organizms have a dual uridine kinase/uracil phosphoribosyltransferase protein where the N-terminal region consists of a UK domain and the C-terminal region of a UPRT domain.


Pssm-ID: 425711 [Multi-domain]  Cd Length: 196  Bit Score: 162.95  E-value: 1.04e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  10 IIGIAGASASGKS----LIASTLYRELREQVGDEHIGVIPEDSYYKDQSHLSMEERVKTNYDH--PNAMDHSLLFQHLEA 83
Cdd:pfam00485   1 VIGVAGSSGSGKTtvarRIVSIFGREGVPAVGIEGDSFHSTDRFYMDLHPEDRKRAGNNGYSFdgPEANDFDLLYEQFKE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  84 LKSGQAIELPVYSYVEHTRTQETIRIEPKKVIILEGILLLTDARLRESMNFSIFVDTPLDICLMRRIKRDVNERGRSMDS 163
Cdd:pfam00485  81 LKEGGSVDKPIYNHVTHERDPTPELIEGADVLVIEGLHALYDERVAQLLDLKIYVDPDIDLELARKIQRDMAERGHSLEG 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1069051796 164 VMAQYQKtVRPMFLQFIEPSKQYADIIVPRGGKNRIA 200
Cdd:pfam00485 161 VTDSILF-RKPDYVNYIDPQFSYADLIIQRVPTNDTA 196
 
Name Accession Description Interval E-value
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 3-213 2.51e-147

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 408.01  E-value: 2.51e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796   3 DKSHQCVIIGIAGASASGKSLIASTLYRELreqvGDEHIGVIPEDSYYKDQSHLSMEERVKTNYDHPNAMDHSLLFQHLE 82
Cdd:PRK05480    1 MMMKKPIIIGIAGGSGSGKTTVASTIYEEL----GDESIAVIPQDSYYKDQSHLSFEERVKTNYDHPDAFDHDLLIEHLK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  83 ALKSGQAIELPVYSYVEHTRTQETIRIEPKKVIILEGILLLTDARLRESMNFSIFVDTPLDICLMRRIKRDVNERGRSMD 162
Cdd:PRK05480   77 ALKAGKAIEIPVYDYTEHTRSKETIRVEPKDVIILEGILLLEDERLRDLMDIKIFVDTPLDIRLIRRLKRDVNERGRSLE 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1069051796 163 SVMAQYQKTVRPMFLQFIEPSKQYADIIVPRGGKNRIAIDILKAKISQFFE 213
Cdd:PRK05480  157 SVINQYLSTVRPMHLQFIEPSKRYADIIIPEGGKNRVAIDILKAKIRQLLE 207
udk TIGR00235
uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in ...
 1-213 2.59e-118

uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in phosphoribulokinase hits at scores of 160 and below [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 272977  Cd Length: 207  Bit Score: 334.74  E-value: 2.59e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796   1 MTDKShqCVIIGIAGASASGKSliasTLYRELREQVGDEHIGVIPEDSYYKDQSHLSMEERVKTNYDHPNAMDHSLLFQH 80
Cdd:TIGR00235   1 MDKPK--GIIIGIGGGSGSGKT----TVARKIYEQLGKLEIVIISQDNYYKDQSHLEMAERKKTNFDHPDAFDNDLLYEH 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  81 LEALKSGQAIELPVYSYVEHTRTQETIRIEPKKVIILEGILLLTDARLRESMNFSIFVDTPLDICLMRRIKRDVNERGRS 160
Cdd:TIGR00235  75 LKNLKNGSPIDVPVYDYVNHTRPKETVHIEPKDVVILEGIMPLFDERLRDLMDLKIFVDTPLDIRLIRRIERDINERGRS 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1069051796 161 MDSVMAQYQKTVRPMFLQFIEPSKQYADIIVPRGGKNRIAIDILKAKISQFFE 213
Cdd:TIGR00235 155 LDSVIDQYRKTVRPMYEQFVEPTKQYADLIIPEGGRNEVAINVLDTKIKHLLE 207
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 10-208 1.60e-102

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 294.46  E-value: 1.60e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  10 IIGIAGASASGKSliasTLYRELREQVGDEHIGVIPEDSYYKDQSHLSMEERVKTNYDHPNAMDHSLLFQHLEALKSGQA 89
Cdd:cd02023     1 IIGIAGGSGSGKT----TVAEEIIEQLGNPKVVIISQDSYYKDLSHEELEERKNNNYDHPDAFDFDLLISHLQDLKNGKS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  90 IELPVYSYVEHTRTQETIRIEPKKVIILEGILLLTDARLRESMNFSIFVDTPLDICLMRRIKRDVNERGRSMDSVMAQYQ 169
Cdd:cd02023    77 VEIPVYDFKTHSRLKETVTVYPADVIILEGILALYDKELRDLMDLKIFVDTDADVRLIRRIERDIVERGRDLESVINQYL 156

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1069051796 170 KTVRPMFLQFIEPSKQYADIIVPRGGKNRIAIDILKAKI 208
Cdd:cd02023   157 KFVKPMHEQFIEPTKRYADVIIPRGGDNHVAIDLIVQHI 195
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 2-210 9.99e-100

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 287.51  E-value: 9.99e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796   2 TDKSHQCVIIGIAGASASGKSLIAstlyRELREQVGDEHIGVIPEDSYYKDQSHLSMEERVKTNYDHPNAMDHSLLFQHL 81
Cdd:COG0572     1 AARSGKPRIIGIAGPSGSGKTTFA----RRLAEQLGADKVVVISLDDYYKDREHLPLDERGKPNFDHPEAFDLDLLNEHL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  82 EALKSGQAIELPVYSYVEHTRTQETIRIEPKKVIILEGILLLTDARLRESMNFSIFVDTPLDICLMRRIKRDVNERGRSM 161
Cdd:COG0572    77 EPLKAGESVELPVYDFATGTRSGETVKVEPADVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRRIVRDGEERGRTA 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1069051796 162 DSVMAQYQKTVRPMFLQFIEPSKQYADIIVPRGG-KNRIAIDILKAKISQ 210
Cdd:COG0572   157 ESVIEQYWATVRPGHEQYIEPTKEYADIVIPNGGpLNPVALDLLVARLLS 206
PTZ00301 PTZ00301
uridine kinase; Provisional
 8-213 1.03e-74

uridine kinase; Provisional


Pssm-ID: 140322 [Multi-domain]  Cd Length: 210  Bit Score: 224.50  E-value: 1.03e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796   8 CVIIGIAGASASGKSLIASTLYRELREQVGDEHIGVIPEDSYYKDQSHLSMEERVKTNYDHPNAMDHSLLFQHLEALKSG 87
Cdd:PTZ00301    3 CTVIGISGASGSGKSSLSTNIVSELMAHCGPVSIGVICEDFYYRDQSNIPESERAYTNYDHPKSLEHDLLTTHLRELKSG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  88 QAIELPVYSYVEHTRTQETIRIEPKKVIILEGILLLTDARLRESMNFSIFVDTPLDICLMRRIKRDVNERGRSMDSVMAQ 167
Cdd:PTZ00301   83 KTVQIPQYDYVHHTRSDTAVTMTPKSVLIVEGILLFTNAELRNEMDCLIFVDTPLDICLIRRAKRDMRERGRTFESVIEQ 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1069051796 168 YQKTVRPMFLQFIEPSKQYADIIVPRGGKNRIAIDILKAKISQFFE 213
Cdd:PTZ00301  163 YEATVRPMYYAYVEPSKVYADIIVPSWKDNSVAVGVLRAKLNHDLE 208
PRK pfam00485
Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop ...
 10-200 1.04e-50

Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop containing kinases: phosphoribulokinases, uridine kinases and bacterial pantothenate kinases(CoaA). Arabidopsis and other organizms have a dual uridine kinase/uracil phosphoribosyltransferase protein where the N-terminal region consists of a UK domain and the C-terminal region of a UPRT domain.


Pssm-ID: 425711 [Multi-domain]  Cd Length: 196  Bit Score: 162.95  E-value: 1.04e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  10 IIGIAGASASGKS----LIASTLYRELREQVGDEHIGVIPEDSYYKDQSHLSMEERVKTNYDH--PNAMDHSLLFQHLEA 83
Cdd:pfam00485   1 VIGVAGSSGSGKTtvarRIVSIFGREGVPAVGIEGDSFHSTDRFYMDLHPEDRKRAGNNGYSFdgPEANDFDLLYEQFKE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  84 LKSGQAIELPVYSYVEHTRTQETIRIEPKKVIILEGILLLTDARLRESMNFSIFVDTPLDICLMRRIKRDVNERGRSMDS 163
Cdd:pfam00485  81 LKEGGSVDKPIYNHVTHERDPTPELIEGADVLVIEGLHALYDERVAQLLDLKIYVDPDIDLELARKIQRDMAERGHSLEG 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1069051796 164 VMAQYQKtVRPMFLQFIEPSKQYADIIVPRGGKNRIA 200
Cdd:pfam00485 161 VTDSILF-RKPDYVNYIDPQFSYADLIIQRVPTNDTA 196
PRK07429 PRK07429
phosphoribulokinase; Provisional
 1-210 6.95e-40

phosphoribulokinase; Provisional


Pssm-ID: 180975  Cd Length: 327  Bit Score: 138.99  E-value: 6.95e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796   1 MTDKSHQCVIIGIAGASASGKSliasTLYRELREQVGDEHIGVIPEDSYYKdqshLSMEERVKTNYD--HPNAMDHSLLF 78
Cdd:PRK07429    1 MTSMPDRPVLLGVAGDSGCGKT----TFLRGLADLLGEELVTVICTDDYHS----YDRKQRKELGITalDPRANNLDIMY 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  79 QHLEALKSGQAIELPVYSYvehtrtqET------IRIEPKKVIILEGILLLTDARLRESMNFSIFVDTPLDICLMRRIKR 152
Cdd:PRK07429   73 EHLKALKTGQPILKPIYNH-------ETgtfdppEYIEPNKIVVVEGLHPLYDERVRELYDFKVYLDPPEEVKIAWKIKR 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1069051796 153 DVNERGRSMDSVMAQYQKTvRPMFLQFIEPSKQYADIIV----PRGGKNRIAIDILKAKISQ 210
Cdd:PRK07429  146 DMAKRGHTYEQVLAEIEAR-EPDFEAYIRPQRQWADVVIqflpTQLIDNDEENKVLRVRLVL 206
PRK cd02026
Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or ...
 10-191 7.44e-38

Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH produced by the primary reactions of photosynthesis.


Pssm-ID: 238984 [Multi-domain]  Cd Length: 273  Bit Score: 132.08  E-value: 7.44e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  10 IIGIAGASASGKSliasTLYRELREQVGDEHIGVIPEDSYYKdqshLSMEERVKTNYD--HPNAMDHSLLFQHLEALKSG 87
Cdd:cd02026     1 IIGVAGDSGCGKS----TFLRRLTSLFGSDLVTVICLDDYHS----LDRKGRKETGITalDPRANNFDLMYEQLKALKEG 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  88 QAIELPVYSYVEHT-RTQEtiRIEPKKVIILEGILLLTDARLRESMNFSIFVDTPLDICLMRRIKRDVNERGRSMDSVMA 166
Cdd:cd02026    73 QAIEKPIYNHVTGLiDPPE--LIKPTKIVVIEGLHPLYDERVRELLDFSVYLDISDEVKFAWKIQRDMAERGHSLEDVLA 150

                         170       180
                  ....*....|....*....|....*
gi 1069051796 167 QYQKTvRPMFLQFIEPSKQYADIIV 191
Cdd:cd02026   151 SIEAR-KPDFEAYIDPQKQYADVVI 174
PLN02348 PLN02348
phosphoribulokinase
 7-191 1.58e-28

phosphoribulokinase


Pssm-ID: 215198  Cd Length: 395  Bit Score: 110.32  E-value: 1.58e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796   7 QCVIIGIAGASASGKSliasTLYRELREQVGDEHIG-----------------VIPEDSYYKDQSHLSMEERVkTNYDhP 69
Cdd:PLN02348   48 GTVVIGLAADSGCGKS----TFMRRLTSVFGGAAKPpkggnpdsntlisdtttVICLDDYHSLDRTGRKEKGV-TALD-P 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  70 NAMDHSLLFQHLEALKSGQAIELPVYSYVEHT-RTQETIriEPKKVIILEGILLLTDARLRESMNFSIFVDTPLDICLMR 148
Cdd:PLN02348  122 RANNFDLMYEQVKALKEGKAVEKPIYNHVTGLlDPPELI--EPPKILVIEGLHPMYDERVRDLLDFSIYLDISDDVKFAW 199

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1069051796 149 RIKRDVNERGRSMDSVMAQYQKTvRPMFLQFIEPSKQYADIIV 191
Cdd:PLN02348  200 KIQRDMAERGHSLESIKASIEAR-KPDFDAYIDPQKQYADVVI 241
UMPK_like cd02028
Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the ...
 10-191 4.46e-23

Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK).


Pssm-ID: 238986 [Multi-domain]  Cd Length: 179  Bit Score: 91.21  E-value: 4.46e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  10 IIGIAGASASGKSLIASTLYRELREQVGDEHigVIPEDSYYKDQSHLSMEErvkTNYDHPNAMDHSLLFQHLEALKSGQA 89
Cdd:cd02028     1 VVGIAGPSGSGKTTFAKKLSNQLRVNGIGPV--VISLDDYYVPRKTPRDED---GNYDFESILDLDLLNKNLHDLLNGKE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  90 IELPVYSYVEHTRTQE-TIRIEPKKVIILEGILLLtDARLRESMNFSIFVDTPLDIC-LMRRIKRDVNERGRSMDSVMAQ 167
Cdd:cd02028    76 VELPIYDFRTGKRRGYrKLKLPPSGVVILEGIYAL-NERLRSLLDIRVAVSGGVHLNrLLRRVVRDIQFRGYSAELTILM 154

                         170       180
                  ....*....|....*....|....
gi 1069051796 168 YQktVRPMFLQFIEPSKQYADIIV 191
Cdd:cd02028   155 WP--SVPSGEEFIIPPLQEAAIVM 176
PLN02318 PLN02318
phosphoribulokinase/uridine kinase
 9-189 8.17e-20

phosphoribulokinase/uridine kinase


Pssm-ID: 177952 [Multi-domain]  Cd Length: 656  Bit Score: 86.84  E-value: 8.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796   9 VIIGIAGASASGKSLIAstlyrelrEQVGD--EHIGVIPEDSYyKDQSHLsmeerVKTNYDHPNAMDHSLLFQHLEALKS 86
Cdd:PLN02318   66 ILVGVAGPSGAGKTVFT--------EKVLNfmPSIAVISMDNY-NDSSRI-----IDGNFDDPRLTDYDTLLDNIHDLKA 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  87 GQAIELPVYSYVEHTRT-QETIRIEPKKVIILEGILLLTDaRLRESMNFSIFVDTPLDICLMRRIKRDVNERGRSMDSVM 165
Cdd:PLN02318  132 GKSVQVPIYDFKSSSRVgYRTLEVPSSRIVIIEGIYALSE-KLRPLLDLRVSVTGGVHFDLVKRVLRDIQRAGQEPEEII 210

                         170       180
                  ....*....|....*....|....
gi 1069051796 166 AQYQKTVRPMFLQFIEPSKQYADI 189
Cdd:PLN02318  211 HQISETVYPMYKAFIEPDLQTAHI 234
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 10-177 9.33e-13

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 63.88  E-value: 9.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  10 IIGIAGASASGKsliaSTLYRELREQVGDehIGVIPEDSYYKDQSHLSMEERVKTNYDHPNAMDHSLLFQHLEALKSGQA 89
Cdd:cd02024     1 IVGISGVTNSGK----TTLAKLLQRILPN--CCVIHQDDFFKPEDEIPVDENGFKQWDVLEALDMEAMMSTLDYWRETGH 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  90 IELPVYS--------------YVEHTRTQETIRIEPKKVIILEGILLLTDARLRESMNFSIFVDTPLDICLMRRIKRD-- 153
Cdd:cd02024    75 FPKFLRShgnendpekefiedAQIEETKADLLGAEDLHILIVDGFLLYNYKPLVDLFDIRYFLRVPYETCKRRREARTgy 154

                         170       180
                  ....*....|....*....|....
gi 1069051796 154 VNERGRSMDSVmAQYQKTVRPMFL 177
Cdd:cd02024   155 VTLEGFWPDPP-GYFDGHVWPMYL 177
CoaA COG1072
Panthothenate kinase [Coenzyme transport and metabolism]; Panthothenate kinase is part of the ...
 10-143 1.28e-10

Panthothenate kinase [Coenzyme transport and metabolism]; Panthothenate kinase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440690  Cd Length: 309  Bit Score: 59.53  E-value: 1.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  10 IIGIAGASASGKSLIASTLYRELREQVGDEHIGVIPEDSYYKDQSHLsmEERvktnydhpNAMD----------HSLLfQ 79
Cdd:COG1072    88 IIGIAGSVAVGKSTTARLLQALLSRWPEHPKVELVTTDGFLYPNAVL--ERR--------GLMDrkgfpesydrRGLL-R 156

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1069051796  80 HLEALKSGQA-IELPVYSYVEHTRTQETIRIEPK-KVIILEGI-LLLTDA----RLRESMNFSIFVDTPLD 143
Cdd:COG1072   157 FLARVKSGDPeVRAPVYSHLLYDIVPGAIVVVDQpDILIVEGNnVLQDEPnpwlFVSDFFDFSIYVDADEE 227
PRK08233 PRK08233
hypothetical protein; Provisional
 104-191 4.08e-08

hypothetical protein; Provisional


Pssm-ID: 181310 [Multi-domain]  Cd Length: 182  Bit Score: 51.28  E-value: 4.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796 104 QETIRIEPKKVIILEGILLLTDARLRESMNFSIFVDTPLDICLMRRIKRDVNErgRSMDSV---MAQYQKTVRPMFLQFI 180
Cdd:PRK08233   70 QELIAKSNVDYIIVDYPFAYLNSEMRQFIDVTIFIDTPLDIAMARRILRDFKE--DTGNEIhndLKHYLNYARPLYLEAL 147

                          90
                  ....*....|.
gi 1069051796 181 EPSKQYADIIV 191
Cdd:PRK08233  148 HTVKPNADIVL 158
PanK cd02025
Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4 ...
 10-194 1.88e-07

Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in CoA biosynthesis.


Pssm-ID: 238983  Cd Length: 220  Bit Score: 49.62  E-value: 1.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  10 IIGIAGASASGKSLIASTLYRELREQVGDEHIGVIPEDSYYKDQSHLsMEERVKTNYDHPNAMDHSLLFQHLEALKSG-Q 88
Cdd:cd02025     1 IIGIAGSVAVGKSTTARVLQALLSRWPDHPNVELITTDGFLYPNKEL-IERGLMDRKGFPESYDMEALLKFLKDIKSGkK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  89 AIELPVYSYVEHTRTQETI-RIEPKKVIILEGILLLTDARLRESM-----NFSIFVDTPLDICLMRRIKRDVNER---GR 159
Cdd:cd02025    80 NVKIPVYSHLTYDVIPGEKqTVDQPDILIIEGLNVLQTGQNPRLFvsdffDFSIYVDADEDDIEKWYIKRFLKLRetaFS 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1069051796 160 SMDSVMAQYQK---------------TV-RPMFLQFIEPSKQYADIIVPRG 194
Cdd:cd02025   160 DPDSYFHRYAKmseeeaiafarevwkNInLKNLRENILPTRNRADLILEKG 210
PRK07667 PRK07667
uridine kinase; Provisional
 10-191 1.95e-06

uridine kinase; Provisional


Pssm-ID: 169051  Cd Length: 193  Bit Score: 46.65  E-value: 1.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  10 IIGIAGASASGKSLIASTLYRELREQVGDEHIgvIPEDSYY---KDQSHLSMEERVKTNYDHpnaMDHSLLFQHL-EALK 85
Cdd:PRK07667   19 ILGIDGLSRSGKTTFVANLKENMKQEGIPFHI--FHIDDYIverNKRYHTGFEEWYEYYYLQ---WDIEWLRQKFfRKLQ 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  86 SGQAIELPVYSYVEHTRTQETIRIEPKKVIILEGILLLTDaRLRESMNFSIFVDTPLDIclmrRIKRDVNERGRSMDSVM 165
Cdd:PRK07667   94 NETKLTLPFYHDETDTCEMKKVQIPIVGVIVIEGVFLQRK-EWRDFFHYMVYLDCPRET----RFLRESEETQKNLSKFK 168

                         170       180
                  ....*....|....*....|....*.
gi 1069051796 166 AQYQKTvRPMFLQFIEPSKQyADIIV 191
Cdd:PRK07667  169 NRYWKA-EDYYLETESPKDR-ADLVI 192
PRK06696 PRK06696
uridine kinase; Validated
 11-191 7.30e-06

uridine kinase; Validated


Pssm-ID: 180660  Cd Length: 223  Bit Score: 45.35  E-value: 7.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  11 IGIAGASASGKSliasTLYRELREQVGDEHIGVIPEDSyykDQSHLSMEERVKTNYDHP-----NAMDHSLLFQH-LEAL 84
Cdd:PRK06696   25 VAIDGITASGKT----TFADELAEEIKKRGRPVIRASI---DDFHNPRVIRYRRGRESAegyyeDAYDYTALRRLlLDPL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069051796  85 KSG--QAIELPVYSYVEHTR-TQETIRIEPKKVIILEGILLLTDaRLRESMNFSIFVDTPLDICLMRRIKRDVNERGrSM 161
Cdd:PRK06696   98 GPNgdRQYRTASHDLKTDIPvHNPPLLAAPNAVLIVDGTFLLRP-ELRDLWDYKIFLDTDFEVSRRRGAKRDTEAFG-SY 175

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1069051796 162 DSVMAQYQKTVRPMFLQFIE---PsKQYADIIV 191
Cdd:PRK06696  176 EEAEKMYLARYHPAQKLYIAeanP-KERADVVI 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH