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Conserved domains on  [gi|1069082889|gb|OEH35700|]
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hypothetical protein AN690_0224315 [Citrobacter freundii]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LpoB super family cl46332
Peptidoglycan-synthase activator LpoB; This is a family of Gram-negative bacterial outer ...
 1-92 5.00e-03

Peptidoglycan-synthase activator LpoB; This is a family of Gram-negative bacterial outer membrane lipoproteins. LpoB is required for the function of the major peptidoglycan synthase enzyme PBP1B. It interacts with PBP1B protein via the UvrB-like non-catalytic domain on that protein. LpoB has a 54-aa-long flexible N-terminal stretch followed by a globular domain with similarity to the N-terminal domain of the prevalent periplasmic protein TolB. The long, flexible N-terminal region of LpoB enables it to span the periplasm and reach its docking site in PBP1B. Peptidoglycan is the essential polymer within the sacculus that surrounds the cytoplasmic membrane of bacteria.


The actual alignment was detected with superfamily member COG3417:

Pssm-ID: 480672  Cd Length: 190  Bit Score: 34.52  E-value: 5.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069082889   1 MKKI-ILSALACTALLTGCVSQdKGNAMQSQlnnqqrQINELSVRLQSAESRLSKQeeKLRNELLQSSGYCYLNGARYst 79
Cdd:COG3417     1 MKKKkLLLVALAALLLAGCAST-PVTYVDPN------EVEDVSGKWNSTDWQAAAE--PMVDSMLSSPWVAKTAGGRP-- 69

                          90
                  ....*....|...
gi 1069082889  80 gTVLYGRIcQNQS 92
Cdd:COG3417    70 -VLLVDSV-KNKT 80
 
Name Accession Description Interval E-value
LpoB COG3417
Outer membrane lipoprotein LpoB, binds and activates PBP1b [Cell wall/membrane/envelope ...
 1-92 5.00e-03

Outer membrane lipoprotein LpoB, binds and activates PBP1b [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442643  Cd Length: 190  Bit Score: 34.52  E-value: 5.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069082889   1 MKKI-ILSALACTALLTGCVSQdKGNAMQSQlnnqqrQINELSVRLQSAESRLSKQeeKLRNELLQSSGYCYLNGARYst 79
Cdd:COG3417     1 MKKKkLLLVALAALLLAGCAST-PVTYVDPN------EVEDVSGKWNSTDWQAAAE--PMVDSMLSSPWVAKTAGGRP-- 69

                          90
                  ....*....|...
gi 1069082889  80 gTVLYGRIcQNQS 92
Cdd:COG3417    70 -VLLVDSV-KNKT 80
 
Name Accession Description Interval E-value
LpoB COG3417
Outer membrane lipoprotein LpoB, binds and activates PBP1b [Cell wall/membrane/envelope ...
 1-92 5.00e-03

Outer membrane lipoprotein LpoB, binds and activates PBP1b [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442643  Cd Length: 190  Bit Score: 34.52  E-value: 5.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1069082889   1 MKKI-ILSALACTALLTGCVSQdKGNAMQSQlnnqqrQINELSVRLQSAESRLSKQeeKLRNELLQSSGYCYLNGARYst 79
Cdd:COG3417     1 MKKKkLLLVALAALLLAGCAST-PVTYVDPN------EVEDVSGKWNSTDWQAAAE--PMVDSMLSSPWVAKTAGGRP-- 69

                          90
                  ....*....|...
gi 1069082889  80 gTVLYGRIcQNQS 92
Cdd:COG3417    70 -VLLVDSV-KNKT 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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