|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
18-331 |
5.41e-76 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 238.68 E-value: 5.41e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 18 GLLNIDMGYHVKVSLFIALIIITIYLFFSRVHFIQSNESMVTKLSRALKGNLQTRLFTNNDRSLNNIVFSINELIAALEK 97
Cdd:COG5002 74 LLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVER 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 98 GQIEARKSQEARKQLLSNISHDIRTPLTSIIGYIDALKDDVATSEVEKQEYLEILYKKSNDLKHLVDEIFNMAKLDADEF 177
Cdd:COG5002 154 DITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGEL 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 178 PLKEEELDFSEVTREVLIEFLPELSKHNIELQVLIPESTSPIIADHLSLIRIIGNLIKNAIHHGKAGKIVGVELLETNTE 257
Cdd:COG5002 234 KLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQ 313
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1078691003 258 YELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNPSYGGSGLGLSISKALVEKNGGRIWVDSIPRERTTFGFSVPK 331
Cdd:COG5002 314 VRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPL 387
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
94-334 |
1.35e-73 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 227.48 E-value: 1.35e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 94 ALEKGQIEARKSQEARKQLLSNISHDIRTPLTSIIGYIDALKDDVATSEVEKQEYLEILYKKSNDLKHLVDEIFNMAKLD 173
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 174 ADEFPLKEEELDFSEVTREVLIEFLPELSKHNIELQVLIPESTSPIIADHLSLIRIIGNLIKNAIHHGKAGKIVGVELLE 253
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 254 TNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNpsYGGSGLGLSISKALVEKNGGRIWVDSIPRERTTFGFSVPKHT 333
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRG--EGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
|
.
gi 1078691003 334 T 334
Cdd:COG2205 239 S 239
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
6-332 |
6.17e-69 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 218.62 E-value: 6.17e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 6 ILFLISLQLIICGLLNIDMGYHVKVSLFIALIIITIYLFFSRVHFIQSNESMVTKLSRALKGNLQTRLFTNNDRSLNNIV 85
Cdd:COG0642 7 LLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 86 FSINELIAALEKGQIEARKSQEARKQLLSNISHDIRTPLTSIIGYIDALKDDVATsevEKQEYLEILYKKSNDLKHLVDE 165
Cdd:COG0642 87 LLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDE---EQREYLETILRSADRLLRLIND 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 166 IFNMAKLDADEFPLKEEELDFSEVTREVLIEFLPELSKHNIELQVLIPESTSPIIADHLSLIRIIGNLIKNAIHHGKAGK 245
Cdd:COG0642 164 LLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 246 IVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNpsYGGSGLGLSISKALVEKNGGRIWVDSIPRERTTF 325
Cdd:COG0642 244 TVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRR--GGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTF 321
|
....*..
gi 1078691003 326 GFSVPKH 332
Cdd:COG0642 322 TVTLPLA 328
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
19-325 |
2.64e-38 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 140.87 E-value: 2.64e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 19 LLNIDMGYHVKVSLFIALIIITIYLFFSRVhfIQSNESMVTKLSRALKGNLQTRLFTNNDRSLNNIVFSINELIAALEKg 98
Cdd:COG5000 122 LLGIPLEELIGKPLEELLPELDLAELLREA--LERGWQEEIELTRDGRRTLLVRASPLRDDGYVIVFDDITELLRAERL- 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 99 qiearksqEARKQLLSNISHDIRTPLTSIIGYIDALK----DDVATSEVEKQEYLEILYKKSNDLKHLVDEIFNMAKLDA 174
Cdd:COG5000 199 --------AAWGELARRIAHEIKNPLTPIQLSAERLRrklaDKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPE 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 175 DEFplkeEELDFSEVTREVLIEFLPELSKHNIELQVLIPESTSPIIADHLSLIRIIGNLIKNAIHHGKAGKIVGVELLET 254
Cdd:COG5000 271 PQL----EPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRRE 346
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1078691003 255 NTEYELLIWDKGPGIPKHDLQNVFkrmyrsehsrNPSY----GGSGLGLSISKALVEKNGGRIWVDSIPRERTTF 325
Cdd:COG5000 347 DGRVRIEVSDNGPGIPEEVLERIF----------EPFFttkpKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTF 411
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
88-334 |
1.19e-35 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 135.30 E-value: 1.19e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 88 INELIAALEKGQIEARKSQEARKQLLSNISHDIRTPLTSIIGYIDALKDDVATSEVEK-QEYLEILYKKSNDLKHLVDEI 166
Cdd:COG4251 261 LEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEDYGDKLDEEgREYLERIRDAAERMQALIDDL 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 167 FNMAKLDADEFPLkeEELDFSEVTREVLIEFLPELSKHNIELQVlipESTSPIIADHLSLIRIIGNLIKNAIHHGKAGK- 245
Cdd:COG4251 341 LAYSRVGRQELEF--EPVDLNELLEEVLEDLEPRIEERGAEIEV---GPLPTVRGDPTLLRQVFQNLISNAIKYSRPGEp 415
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 246 -IVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSeHSRNpSYGGSGLGLSISKALVEKNGGRIWVDSIPRERTT 324
Cdd:COG4251 416 pRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRL-HSRD-EYEGTGIGLAIVKKIVERHGGRIWVESEPGEGAT 493
|
250
....*....|
gi 1078691003 325 FGFSVPKHTT 334
Cdd:COG4251 494 FYFTLPKAPA 503
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
63-319 |
2.17e-35 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 133.80 E-value: 2.17e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 63 RALKGNLQTRLFTNNDRSLNNIVFSINELIAALEKgqiearkSQEARKQLLSNISHDIRTPLTSIIGYIDALKDDVATSE 142
Cdd:NF012163 201 RLAAGDYTTRVTPTSNDELGKLAQDFNQLASTLEK-------NEQMRRDFMADISHELRTPLAVLRAELEAIQDGIRKFT 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 143 vekQEYLEILYKKSNDLKHLVDEIFNMAKLDADEFPLKEEELDFSEVTREVLIEFLPELSKHNIELQVLIPEStSPIIAD 222
Cdd:NF012163 274 ---PESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEVEGGAFRERFASAGLELEVSLPDS-SLVFGD 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 223 HLSLIRIIGNLIKNAIHHGKAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNPSYGGSGLGLSIS 302
Cdd:NF012163 350 RDRLMQLFNNLLENSLRYTDSGGSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAIS 429
|
250
....*....|....*..
gi 1078691003 303 KALVEKNGGRIWVDSIP 319
Cdd:NF012163 430 LNIVQAHGGTLHAAHSP 446
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
6-332 |
3.38e-34 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 128.76 E-value: 3.38e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 6 ILFLISLQLIICGLLNIDMGYHVKVSLFIALIIITIYLFFSRVHFIQSNESMVTKLSRALKGNLQTRLFTNNDRSLNNIV 85
Cdd:COG4191 30 LLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAEL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 86 FSINELIAALEKGQIEARKSQE----ARK-----QLLSNISHDIRTPLTSIIGYIDALKDDVATS--EVEKQEYLEILYK 154
Cdd:COG4191 110 EELERDITELERAEEELRELQEqlvqSEKlaalgELAAGIAHEINNPLAAILGNAELLRRRLEDEpdPEELREALERILE 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 155 KSNDLKHLVDEIFNMAKLDADEFplkeEELDFSEVTREVLIEFLPELSKHNIELQVLIPESTSPIIADHLSLIRIIGNLI 234
Cdd:COG4191 190 GAERAAEIVRSLRAFSRRDEEER----EPVDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 235 KNAIH---HGKAGKIVgVELLETNTEYELLIWDKGPGIPKHDLQNVF------KrmyrsehsrnPSYGGSGLGLSISKAL 305
Cdd:COG4191 266 INAIDameEGEGGRIT-ISTRREGDYVVISVRDNGPGIPPEVLERIFepffttK----------PVGKGTGLGLSISYGI 334
|
330 340
....*....|....*....|....*..
gi 1078691003 306 VEKNGGRIWVDSIPRERTTFGFSVPKH 332
Cdd:COG4191 335 VEKHGGRIEVESEPGGGTTFTITLPLA 361
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
110-330 |
2.64e-30 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 117.96 E-value: 2.64e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 110 KQLLSNISHDIRTPLTSIIGYIDALKDDVATSEveKQEYLEILYKKSNDLKHLVDEIFNMAKLDADEFplkeEELDFSEV 189
Cdd:COG5807 148 GELAAGIAHEIRNPLTSIKGFLQLLQESREDSE--REEYFNIIISEIDRINTIITELLVLSKPKKFNF----KKLNLNDV 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 190 TREVLIEFLPELSKHNIELQVLIPESTSPIIADHLSLIRIIGNLIKNAIHHGKAGKIVGVELLETNTEYELLIWDKGPGI 269
Cdd:COG5807 222 LEDVIALLSTEAILKNISIKYDLADDEPVINGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISVKDEGIGI 301
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1078691003 270 PKHDLQNVFKRMYRSEHSrnpsygGSGLGLSISKALVEKNGGRIWVDSIPRERTTFGFSVP 330
Cdd:COG5807 302 PEEVLEKIGEPFFTTKEE------GTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLP 356
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
91-330 |
1.09e-29 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 119.76 E-value: 1.09e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 91 LIA-ALEKGQIEARKSQ--------EARKQLLSNISHDIRTPLTSIIGYIDALKDDVAT---------SEVEKQeyleIL 152
Cdd:PRK10490 637 LIAnALERLTLTASEEQarlasereQLRNALLAALSHDLRTPLTVLFGQAEILTLDLASegspharqaSEIRQQ----VL 712
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 153 ykksnDLKHLVDEIFNMAKLDADEFPLKEEELDFSEVTREVLIEFLPELSKHNIELQvlIPESTSPIIADHLSLIRIIGN 232
Cdd:PRK10490 713 -----NTTRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLS--LPEPLTLIHVDGPLFERVLIN 785
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 233 LIKNAIHHGKAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEhsRNPSYGGSGLGLSISKALVEKNGGR 312
Cdd:PRK10490 786 LLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGN--KESAIPGVGLGLAICRAIVEVHGGT 863
|
250
....*....|....*...
gi 1078691003 313 IWVDSIPRERTTFGFSVP 330
Cdd:PRK10490 864 IWAENRPEGGACFRVTLP 881
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
207-325 |
1.31e-29 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 109.91 E-value: 1.31e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 207 ELQVLIPESTSPIIADHLSLIRIIGNLIKNAIHHGKAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEH 286
Cdd:cd16947 2 QVEINIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLED 81
|
90 100 110
....*....|....*....|....*....|....*....
gi 1078691003 287 SRNPSYGGSGLGLSISKALVEKNGGRIWVDSIPRERTTF 325
Cdd:cd16947 82 SRNSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVF 120
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
96-325 |
2.33e-29 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 115.33 E-value: 2.33e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 96 EKGQIEARKSQEAR----KQLLSNISHDIRTPLTSIIGYIDALKDDVATSEVekQEYLEILYKKSNDLKHLVDEIFNMAK 171
Cdd:COG3852 118 ERKRLERELRRAEKlaavGELAAGLAHEIRNPLTGIRGAAQLLERELPDDEL--REYTQLIIEEADRLNNLVDRLLSFSR 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 172 LDADEFplkeEELDFSEVTREVLIEFLPELsKHNIELQVLIPESTSPIIADHLSLIRIIGNLIKNAIHH-GKAGKIV--- 247
Cdd:COG3852 196 PRPPER----EPVNLHEVLERVLELLRAEA-PKNIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAmPEGGTITirt 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 248 ----GVELLETNTEYELL--IWDKGPGIPKHDLQNVFkrmyrsehsrNPSY----GGSGLGLSISKALVEKNGGRIWVDS 317
Cdd:COG3852 271 rverQVTLGGLRPRLYVRieVIDNGPGIPEEILDRIF----------EPFFttkeKGTGLGLAIVQKIVEQHGGTIEVES 340
|
....*...
gi 1078691003 318 IPRERTTF 325
Cdd:COG3852 341 EPGKGTTF 348
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
226-325 |
4.92e-29 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 107.69 E-value: 4.92e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 226 LIRIIGNLIKNAIHHGKAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNpsYGGSGLGLSISKAL 305
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSRE--GGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|
gi 1078691003 306 VEKNGGRIWVDSIPRERTTF 325
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTF 98
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
221-331 |
5.02e-29 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 107.73 E-value: 5.02e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 221 ADHLSLIRIIGNLIKNAIHHGKAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEhSRNPSYGGSGLGLS 300
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD-KRSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 1078691003 301 ISKALVEKNGGRIWVDSIPRERTTFGFSVPK 331
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
67-319 |
1.41e-27 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 112.03 E-value: 1.41e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 67 GNLQTRLFTNNDRSLNNIVFSINELIAALEKgqiearkSQEARKQLLSNISHDIRTPLTSIIGYIDALKDDV----ATSE 142
Cdd:PRK10549 205 GDFTTRVTPTSRDELGRLAQDFNQLASTLEK-------NEQMRRDFMADISHELRTPLAVLRGELEAIQDGVrkftPESV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 143 VEKQEYLEILYKksndlkhLVDEIFNMAKLDADEFPLKEEELDFSEVTREVLIEFLPELSKHNIELQVLIPEStSPIIAD 222
Cdd:PRK10549 278 ASLQAEVGTLTK-------LVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDS-ATVFGD 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 223 HLSLIRIIGNLIKNAIHHGKAGKIVGVELLETNtEYELLIW-DKGPGIPKHDLQNVFKRMYRSEHSRNPSYGGSGLGLSI 301
Cdd:PRK10549 350 PDRLMQLFNNLLENSLRYTDSGGSLHISAEQRD-KTLRLTFaDSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAI 428
|
250
....*....|....*...
gi 1078691003 302 SKALVEKNGGRIWVDSIP 319
Cdd:PRK10549 429 CLNIVEAHNGRIIAAHSP 446
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
96-330 |
2.47e-27 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 110.43 E-value: 2.47e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 96 EKGQIEAR-KSQEarkQLLSNISHDIRTPLT--SI------IGYIDalkDDVATSEVEKQEYLEILYKKSNDLKHLVDEI 166
Cdd:PRK09303 140 ENETLLEQlKFKD---RVLAMLAHDLRTPLTaaSLaletleLGQID---EDTELKPALIEQLQDQARRQLEEIERLITDL 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 167 FNMAKLDADEFPLKEEELDFSEVTREVLIEFLPELSKHNIELQVLIPESTSPIIADHlSLIR-IIGNLIKNAIHHGKAGK 245
Cdd:PRK09303 214 LEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLPSVYADQ-ERIRqVLLNLLDNAIKYTPEGG 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 246 IVGVELLE-TNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNPSygGSGLGLSISKALVEKNGGRIWVDSIPRERTT 324
Cdd:PRK09303 293 TITLSMLHrTTQKVQVSICDTGPGIPEEEQERIFEDRVRLPRDEGTE--GYGIGLSVCRRIVRVHYGQIWVDSEPGQGSC 370
|
....*.
gi 1078691003 325 FGFSVP 330
Cdd:PRK09303 371 FHFTLP 376
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
30-332 |
2.69e-26 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 108.71 E-value: 2.69e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 30 VSLFIALIIITIYLFFsrvhfIQSNESMVTKLSRALKG----NLQTRLftNNDR---SLNNIVFSINELIAALEkgQIEA 102
Cdd:PRK09835 190 TASVISLLIVFIVLLA-----VHKGHAPIRSVSRQIQNitskDLDVRL--DPQTvpiELEQLVLSFNHMIERIE--DVFT 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 103 RKSQearkqLLSNISHDIRTPLTSIIgyidaLKDDVATSEVEKQEYLE-ILY---KKSNDLKHLVDEIFNMAKLDADEFP 178
Cdd:PRK09835 261 RQSN-----FSADIAHEIRTPITNLI-----TQTEIALSQSRSQKELEdVLYsnlEELTRMAKMVSDMLFLAQADNNQLI 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 179 LKEEELDFSEVTREVLIEFLPELSKHNIELQVlipESTSPIIA-DHLSLIRIIGNLIKNAIHHGKAGKIVGVELLETNTE 257
Cdd:PRK09835 331 PEKKMLDLADEVGKVFDFFEAWAEERGVELRF---VGDPCQVAgDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQ 407
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1078691003 258 YELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNPSYGGSGLGLSISKALVEKNGGRIWVDSIPRErTTFGFSVPKH 332
Cdd:PRK09835 408 VQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARG-TRFVISLPRL 481
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
88-335 |
4.82e-26 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 107.38 E-value: 4.82e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 88 INELIAAlekgqiearksqeaRKQLLSNISHDIRTPLTSIiGYIDALKDDVATSEvekQEYLEilyKKSNDLKHLVDEIF 167
Cdd:PRK10604 205 INALIAS--------------KKQLIDGIAHELRTPLVRL-RYRLEMSDNLSAAE---SQALN---RDIGQLEALIEELL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 168 NMAKLDADEFPLKEEELDFSEVTREVLIEFlpELSKHNIELQVLIPESTSPIIADHLSLIRIIGNLIKNAIHHgkAGKIV 247
Cdd:PRK10604 264 TYARLDRPQNELHLSEPDLPAWLSTHLADI--QAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRY--AHSRV 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 248 GVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNPSYGGSGLGLSISKALVEKNGGRIWVDSIPRERTTFGF 327
Cdd:PRK10604 340 RVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSF 419
|
....*...
gi 1078691003 328 SVPKHTTF 335
Cdd:PRK10604 420 SWPVWHNL 427
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
111-333 |
8.53e-25 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 104.29 E-value: 8.53e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 111 QLLSNISHDIRTPLTSIIGYIDALKDDVatsEVEKQEYLEILYKKSNDLKHLVDEIFNMAKLDADEFplkeEELDFSEVT 190
Cdd:COG5809 272 ELAAGIAHEIRNPLTSLKGFIQLLKDTI---DEEQKTYLDIMLSELDRIESIISEFLVLAKPQAIKY----EPKDLNTLI 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 191 REVLIEFLPELSKHNIELQVLIPESTSPIIADHLSLIRIIGNLIKNAIHHGKAGKIVGVELLETNTEY-ELLIWDKGPGI 269
Cdd:COG5809 345 EEVIPLLQPQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDKvVISVTDEGCGI 424
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1078691003 270 PKHDLQNVFKRMYrsehsrNPSYGGSGLGLSISKALVEKNGGRIWVDSIPRERTTFGFSVPKHT 333
Cdd:COG5809 425 PEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKL 482
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
221-330 |
2.08e-24 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 95.51 E-value: 2.08e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 221 ADHLSLIRIIGNLIKNAIHHGKAGKIVGVELlETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSrnpSYGGSGLGLS 300
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTL-SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKR---GGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|
gi 1078691003 301 ISKALVEKNGGRIWVDSIPRERTTFGFSVP 330
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
226-330 |
1.64e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 90.63 E-value: 1.64e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 226 LIRIIGNLIKNAIHHGKAGKI-VGVELLETNTEYELL---IWDKGPGIPKHDLQNVFKRMYRSEHSRNPSYGGSGLGLSI 301
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEVtLRVSLEEEEEDGVQLrfsVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 1078691003 302 SKALVEKNGGRIWVDSIPRERTTFGFSVP 330
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
112-330 |
3.64e-21 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 94.26 E-value: 3.64e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 112 LLSNISHDIRTPLTSIIGYIDALKDdvATSEVEKQEYLEILYKKSNDLKHLVDEIFNMAKldadefPLKE--EELDFSEV 189
Cdd:PRK11360 393 LVAGVAHEIRNPLTAIRGYVQIWRQ--QTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSR------PRESqwQPVSLNAL 464
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 190 TREVLIEFLPELSKHNIELQVLIPESTSPIIADHLSLIRIIGNLIKNAIHHGKAGKIVGVEL-LETNTEYELLIWDKGPG 268
Cdd:PRK11360 465 VEEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTwQYSDGQVAVSIEDNGCG 544
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1078691003 269 IPKHDLQNVFKRMYRSEHSrnpsygGSGLGLSISKALVEKNGGRIWVDSIPRERTTFGFSVP 330
Cdd:PRK11360 545 IDPELLKKIFDPFFTTKAK------GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
90-330 |
5.46e-21 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 94.03 E-value: 5.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 90 ELIAALEKGQIEARKSQEARKQLLSNISHDIRTPLTSIIGYIDALKDDVATSEvEKQEYLEILYKKSNDLKHLVDEIFNM 169
Cdd:PRK09959 693 DLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKE-QRVEAISLAYATGQSLLGLIGEILDV 771
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 170 AKLDADEFPLKEEELDFSEVTREVLIEFLPELSKHNIELQVlipESTSP----IIADHLSLIRIIGNLIKNAIHHGKAGK 245
Cdd:PRK09959 772 DKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSC---SSTFPdhylVKIDPQAFKQVLSNLLSNALKFTTEGA 848
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 246 I-VGVELLETNTEY---ELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNPSygGSGLGLSISKALVEKNGGRIWVDSIPRE 321
Cdd:PRK09959 849 VkITTSLGHIDDNHaviKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGI 926
|
....*....
gi 1078691003 322 RTTFGFSVP 330
Cdd:PRK09959 927 GTTFTITIP 935
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
108-337 |
7.04e-21 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 92.77 E-value: 7.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 108 ARKQLLSNISHDIRTPLTSIIGYIDALKDDVATSEVEKQEyLEILYKKSNDLKHLVDEIFNMAKLDADEFPLKEEELDFS 187
Cdd:PRK11006 203 ARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKA-LHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVP 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 188 EVTReVLIEFLPELS--KHNIELQVlipESTSPIIADHLSLIRIIGNLIKNAIHHGKAGKIVGVELLETNTEYELLIWDK 265
Cdd:PRK11006 282 MMLR-VLEREAQTLSqgKHTITFEV---DNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDN 357
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1078691003 266 GPGIPKHDLQNVFKRMYRSEHSRNPSYGGSGLGLSISKALVEKNGGRIWVDSIPRERTTFGFSVPKHTTFKK 337
Cdd:PRK11006 358 GPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPERLIAKN 429
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
116-331 |
1.66e-20 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 91.06 E-value: 1.66e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 116 ISHDIRTPLTSIIGYIDALKDDVAtsevekQEYLEILYKKSNDLKHLVDEIFNMAKLDAdefplkeeeldfsevtreVLI 195
Cdd:COG3290 196 QRHDFRNHLHTISGLLQLGEYDEA------LEYIDEISEELQELIDSLLSRIGNPVLAA------------------LLL 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 196 EFLPELSKHNIELQVLIPESTSPIIADHLSLIRIIGNLIKNAIHHGKAG----KIVGVELLETNTEYELLIWDKGPGIPK 271
Cdd:COG3290 252 GKAARARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAVEKLpeeeRRVELSIRDDGDELVIEVEDSGPGIPE 331
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 272 HDLQNVFKRMYRSEHSrnpsyGGSGLGLSISKALVEKNGGRIWVDSIPRERTTFGFSVPK 331
Cdd:COG3290 332 ELLEKIFERGFSTKLG-----EGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPK 386
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
226-319 |
2.70e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 79.04 E-value: 2.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 226 LIRIIGNLIKNAIHHGKAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNPSYGGSGLGLSISKAL 305
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAICHNI 84
|
90
....*....|....
gi 1078691003 306 VEKNGGRIWVDSIP 319
Cdd:cd16946 85 ALAHGGTISAEHSP 98
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
103-334 |
1.56e-17 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 83.75 E-value: 1.56e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 103 RKSQEA---RKQLLSNISHDIRTPLTSIIGYI-DALKDDVATSEvekQEYLEILYKKSNDLKHLVDEIFNMAKLDADEFP 178
Cdd:PRK11107 284 KRAQEAariKSEFLANMSHELRTPLNGVIGFTrQTLKTPLTPTQ---RDYLQTIERSANNLLAIINDILDFSKLEAGKLV 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 179 LkeEELDFSevTREVLIEFLPEL--SKH--NIELQVLI----PEStspIIADHLSLIRIIGNLIKNAIHHGKAGKI-VGV 249
Cdd:PRK11107 361 L--ENIPFS--LRETLDEVVTLLahSAHekGLELTLNIdpdvPDN---VIGDPLRLQQIITNLVGNAIKFTESGNIdILV 433
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 250 ELLE---TNTEYELLIWDKGPGIPKHDLQNVFK--RMYRSEHSRNpsYGGSGLGLSISKALVEKNGGRIWVDSIPRERTT 324
Cdd:PRK11107 434 ELRAlsnTKVQLEVQIRDTGIGISERQQSQLFQafRQADASISRR--HGGTGLGLVITQKLVNEMGGDISFHSQPNRGST 511
|
250
....*....|
gi 1078691003 325 FGFSVPKHTT 334
Cdd:PRK11107 512 FWFHLPLDLN 521
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
68-330 |
2.07e-17 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 83.15 E-value: 2.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 68 NLQTRLFTNNDRSLNNIVFSINELIAALEK--GQIEARKSQ------EARKQL----------LSNISHDIRTPLTSIIG 129
Cdd:PRK15347 339 ALEPRLPENRLDELGSIAKAYNQLLDTLNEqyDTLENKVAErtqalaEAKQRAeqankrksehLTTISHEIRTPLNGVLG 418
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 130 YIDALKDdvATSEVEKQEYLEILYKKSNDLKHLVDEIFNMAKLDADEFPLKEEELDFSEVTREVLIEF-LPELSKhNIEL 208
Cdd:PRK15347 419 ALELLQN--TPLTAEQMDLADTARQCTLSLLAIINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIqGPAQSK-SLTL 495
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 209 QVLI-PESTSPIIADHLSLIRIIGNLIKNAIHHGKAGKIVgvelLETNTEYELLIW---DKGPGIPKHDLQNVFKRMYRS 284
Cdd:PRK15347 496 RTFVgAHVPLYLHLDSLRLRQILVNLLGNAVKFTETGGIR----LRVKRHEQQLCFtveDTGCGIDIQQQQQIFTPFYQA 571
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1078691003 285 EHSRnpsyGGSGLGLSISKALVEKNGGRIWVDSIPRERTTFGFSVP 330
Cdd:PRK15347 572 DTHS----QGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
88-320 |
5.91e-17 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 81.43 E-value: 5.91e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 88 INELIAALE--KGQIEARKSQEARKQLLSnisHDIRTPLTSIIGYIDALKDDvaTSEVEKQEYLEILYKKSNDLKHLVDE 165
Cdd:PRK11100 236 LRELAQALEsmRVKLEGKAYVEQYVQTLT---HELKSPLAAIRGAAELLQED--PPPEDRARFTGNILTQSARLQQLIDR 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 166 IFNMAKLDADEFPLKEEELDFSEVTREVLIEFLPELSKHNIELQVLIPESTspIIADHLSLIRIIGNLIKNAIHHGKAGK 245
Cdd:PRK11100 311 LLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPDDAR--VLGDPFLLRQALGNLLDNAIDFSPEGG 388
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1078691003 246 IVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMY---RSEHSRNpsygGSGLGLSISKALVEKNGGRIWVDSIPR 320
Cdd:PRK11100 389 TITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPE 462
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
114-330 |
7.28e-17 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 81.53 E-value: 7.28e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 114 SNISHDIRTPLTSIIGYIDALKDDVATSEVEKqeYLEILYKKSNDLKHLVDEIFNMAKLDADEFPLKEEELDFSEVTREV 193
Cdd:PRK11091 288 STISHELRTPLNGIVGLSRILLDTELTAEQRK--YLKTIHVSAITLGNIFNDIIDMDKMERRKLQLDNQPIDFTDFLADL 365
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 194 --LIEFLPELS--KHNIELQVLIPEStspIIADHLSLIRIIGNLIKNAIHHGKAGKIVGVELLETNTEYELLIWDKGPGI 269
Cdd:PRK11091 366 enLSGLQAEQKglRFDLEPLLPLPHK---VITDGTRLRQILWNLISNAVKFTQQGGVTVRVRYEEGDMLTFEVEDSGIGI 442
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1078691003 270 PKHDLQNVFKrMY---RSEHSRNPSYGgSGLGLSISKALVEKNGGRIWVDSIPRERTTFGFSVP 330
Cdd:PRK11091 443 PEDELDKIFA-MYyqvKDSHGGKPATG-TGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
111-331 |
2.57e-16 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 79.39 E-value: 2.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 111 QLLSNISHDIRTPLTSIIGYIDALKddvaTSEVEKQEYLEILYKKSNDLKHLVDEIFNMAKLDADEFplkeEELDFSEVT 190
Cdd:COG5805 289 QLAAGIAHEIRNPLTSIKGFLQLLQ----PGIEDKEEYFDIMLSELDRIESIISEFLALAKPQAVNK----EKENINELI 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 191 REVLIEFLPELSKHNIELQVLIPESTSPIIADHLSLIRIIGNLIKNAIHHGKAGKIVGVELLETNTEYELLIWDKGPGIP 270
Cdd:COG5805 361 QDVVTLLETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIP 440
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1078691003 271 KHDLQNVFKRMYRSEHSrnpsygGSGLGLSISKALVEKNGGRIWVDSIPRERTTFGFSVPK 331
Cdd:COG5805 441 EERLKKLGEPFFTTKEK------GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
222-323 |
1.11e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 72.05 E-value: 1.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 222 DHLSLIRIIGNLIKNAIHHGKAGKIVGVELLETNTEyELLIWDKGPGIPKHDLQNVFKRMYRSEHSrnpSYGGSGLGLSI 301
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGA-VIRVEDNGPGIDEEELEALFERFYRSDGQ---NYGGSGLGLSI 85
|
90 100
....*....|....*....|..
gi 1078691003 302 SKALVEKNGGRIWVDSIPRERT 323
Cdd:cd16940 86 VKRIVELHGGQIFLGNAQGGGL 107
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
226-320 |
1.51e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 71.59 E-value: 1.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 226 LIRIIGNLIKNAIHHgkAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNPSYGGSGLGLSISKAL 305
Cdd:cd16949 1 LARALENVLRNALRY--SPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90
....*....|....*
gi 1078691003 306 VEKNGGRIWVDSIPR 320
Cdd:cd16949 79 IEQHGGKIKASNRKP 93
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
102-330 |
2.68e-15 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 76.36 E-value: 2.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 102 ARKSQEARKQLL----------------SNISHDIRTPLTSIIGYIDALKDDvATSEVEKQEYLEILYKKSNDLKHLVDE 165
Cdd:PRK10364 214 YRRYLRSRQLLQdemkrkeklvalghlaAGVAHEIRNPLSSIKGLAKYFAER-APAGGEAHQLAQVMAKEADRLNRVVSE 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 166 IFNMAKldadefP--LKEEELDFSEVTREVLIEFLPELSKHNIELQVLIPESTSPIIADHLSLIRIIGNLIKNAIHHGKA 243
Cdd:PRK10364 293 LLELVK------PthLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQ 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 244 GKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSrnpsygGSGLGLSISKALVEKNGGRIWVDSIPRERT 323
Cdd:PRK10364 367 HGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAE------GTGLGLAVVHNIVEQHGGTIQVASQEGKGA 440
|
....*..
gi 1078691003 324 TFGFSVP 330
Cdd:PRK10364 441 TFTLWLP 447
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
108-174 |
3.88e-15 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 69.16 E-value: 3.88e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1078691003 108 ARKQLLSNISHDIRTPLTSIIGYIDALKDDVATSEVekQEYLEILYKKSNDLKHLVDEIFNMAKLDA 174
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQ--REYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
106-171 |
9.32e-15 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 68.01 E-value: 9.32e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1078691003 106 QEARKQLLSNISHDIRTPLTSIIGYIDALKDDVATSEvEKQEYLEILYKKSNDLKHLVDEIFNMAK 171
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDE-EQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
108-174 |
9.87e-15 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 67.98 E-value: 9.87e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1078691003 108 ARKQLLSNISHDIRTPLTSIIGYIDALKDDVATSevEKQEYLEILYKKSNDLKHLVDEIFNMAKLDA 174
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSE--EQREYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
226-330 |
9.88e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 69.28 E-value: 9.88e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 226 LIRIIGNLIKNAIH--HGKAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSeHSRNpSYGGSGLGLSISK 303
Cdd:cd16921 1 LGQVLTNLLGNAIKfrRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRL-HSRE-EYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 1078691003 304 ALVEKNGGRIWVDSIPRERTTFGFSVP 330
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
109-313 |
1.18e-14 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 74.18 E-value: 1.18e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 109 RKQLLSNISHDIRTPLTSIigyidalkdDVATsE--VEKQEYL-EILYKKSNDLKHLVDEIFNMAKLDADEfplKEEELD 185
Cdd:PRK09467 229 RTLLMAGVSHDLRTPLTRI---------RLAT-EmmSEEDGYLaESINKDIEECNAIIEQFIDYLRTGQEM---PMEMAD 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 186 FSEVTREVLieflpeLSKHNIELQVL--IPESTSPIIADHLSLIRIIGNLIKNAIHHGKaGKIvgvellETNTEYEL-LI 262
Cdd:PRK09467 296 LNALLGEVI------AAESGYEREIEtaLQPGPIEVPMNPIAIKRALANLVVNAARYGN-GWI------KVSSGTEGkRA 362
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1078691003 263 W----DKGPGIPKHDLQNVFKRMYRSEHSRNPSygGSGLGLSISKALVEKNGGRI 313
Cdd:PRK09467 363 WfqveDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKV 415
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
79-319 |
2.35e-14 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 73.43 E-value: 2.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 79 RSLNNIVFSINELIaalekgqiearksqEARKQLLSNISHDIRTPLTSIigyidalkdDVAT----------SEVEKQEy 148
Cdd:PRK09470 227 ASFNQMVTALERMM--------------TSQQRLLSDISHELRTPLTRL---------QLATallrrrqgesKELERIE- 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 149 LEI--LYKKSNDL---------KHLVDEIFNMAKLdadefplkeeeldFSEVTREVliEFlpELSKHNIELQVLIPESTS 217
Cdd:PRK09470 283 TEAqrLDSMINDLlvlsrnqqkNHLERETFKANSL-------------WSEVLEDA--KF--EAEQMGKSLTVSAPPGPW 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 218 PIIADHLSLIRIIGNLIKNAIHHGKagKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNPSYGGSGL 297
Cdd:PRK09470 346 PINGNPNALASALENIVRNALRYSH--TKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGL 423
|
250 260
....*....|....*....|..
gi 1078691003 298 GLSISKALVEKNGGRIWVDSIP 319
Cdd:PRK09470 424 GLAIVENAIQQHRGWVKAEDSP 445
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
230-330 |
5.27e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 67.23 E-value: 5.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 230 IGNLIKNAIHHGKAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNPSYGGSGLGLSISKALVEKN 309
Cdd:cd16952 5 FSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRH 84
|
90 100
....*....|....*....|.
gi 1078691003 310 GGRIWVDSIPRERTTFGFSVP 330
Cdd:cd16952 85 DARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
229-330 |
2.65e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 65.11 E-value: 2.65e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 229 IIGNLIKNAIHHGKAGKIVGVELLETNT-----EYELLIWDKGPGIPKHDLQNVFKRMYRSEHSrnpsygGSGLGLSISK 303
Cdd:cd16920 4 VLINLVRNGIEAMSEGGCERRELTIRTSpaddrAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLSICR 77
|
90 100
....*....|....*....|....*..
gi 1078691003 304 ALVEKNGGRIWVDSIPRERTTFGFSVP 330
Cdd:cd16920 78 SIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
228-330 |
5.83e-13 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 64.44 E-value: 5.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 228 RIIGNLIKNAIHHGKAGKIVGVELLETNTEYELL-IWDKGPGIPKHDLQNVFKRMYRSEHSRNPSYGGSGLGLSISKALV 306
Cdd:cd16925 7 RVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLLtVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIVKEFV 86
|
90 100
....*....|....*....|....
gi 1078691003 307 EKNGGRIWVDSIPRERTTFGFSVP 330
Cdd:cd16925 87 ELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
88-330 |
7.87e-13 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 69.55 E-value: 7.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 88 INELIAALEKGQIEARKSQEARKQLLSNISHDIRTPLTSIIGYIDALKDDVATSevEKQEYLEILYKKSNDLKHLVDEIF 167
Cdd:PRK11466 423 LQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALN--AQRDDLRAITDSGESLLTILNDIL 500
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 168 NMAKLDA--DEFPLKEEELDFSEVTREVLIEFLPELSKHNIELQVLIPEST-SPIIADHLSLIRIIGNLIKNAIHHGKAG 244
Cdd:PRK11466 501 DYSAIEAggKNVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDLpTALMGDPRRIRQVITNLLSNALRFTDEG 580
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 245 KIVgVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSRnpsyGGSGLGLSISKALVEKNGGRIWVDSIPRERTT 324
Cdd:PRK11466 581 SIV-LRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSC 655
|
....*.
gi 1078691003 325 FGFSVP 330
Cdd:PRK11466 656 FCLRLP 661
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
84-301 |
1.05e-12 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 68.52 E-value: 1.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 84 IVFSINELIAalekgQIEARKSQEARkqLLSNISHDIRTPLTsiigyidALK--DDVAT----SEVEKQEYLEILYKKSN 157
Cdd:PRK10337 219 LVEALNQLFA-----RTHAMMVRERR--FTSDAAHELRSPLA-------ALKvqTEVAQlsddDPQARKKALLQLHAGID 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 158 DLKHLVDEIFNMAKLDADEFPLKEEELDFSEVTREVLIEFLPELSKHNIELQVLIPesTSPII--ADHLSLIRIIGNLIK 235
Cdd:PRK10337 285 RATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLN--AHPVIrtGQPLLLSLLVRNLLD 362
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1078691003 236 NAIHHGKAGKIVGVELletnTEYELLIWDKGPGIPKHDLQNVFKRMYR---SEHSrnpsygGSGLGLSI 301
Cdd:PRK10337 363 NAIRYSPQGSVVDVTL----NARNFTVRDNGPGVTPEALARIGERFYRppgQEAT------GSGLGLSI 421
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
111-330 |
1.14e-12 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 68.36 E-value: 1.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 111 QLLSNISHDIRTPLTSIIGYIDALKDDvATSEVEKQEYLEILYKKSNDLKHLVDEIFNMAKldadefPLKE--EELDFSE 188
Cdd:COG5806 203 ELAASIAHEVRNPLTVVRGFIQLLQEP-ELSDEKRKQYIRIALEELDRAEAIITDYLTFAK------PQPEklEKIDVSE 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 189 VTREVLIEFLPELSKHNIELQVLIPESTSpIIADHLSLIRIIGNLIKNAIHHGKAGKIVGVELLETNTEYELLIWDKGPG 268
Cdd:COG5806 276 ELEHVIDVLSPYANMNNVEIQTELEPGLY-IEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVG 354
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1078691003 269 ipkhdlqnvfkrMYRSEHSR--NPSYG----GSGLGLSISKALVEKNGGRIWVDSIPRERTTFGFSVP 330
Cdd:COG5806 355 ------------MTKEQLERlgEPYFStkekGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLP 410
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
95-330 |
1.63e-12 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 68.42 E-value: 1.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 95 LEKGQIEARKSQEARKQLLSNISHDIRTPLTSIIGYIDALKDDvaTSEVEKQEYLEILYKKSNDLKHLVDEIFNMAKLDA 174
Cdd:PRK10618 436 LQQAQREYEKNQQARKAFLQNIGDELKQPLQSLAQLAAQLRQT--SDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLET 513
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 175 DEFPLKEEELDFSEVTREVLIEFLPELSKHNIELQV---LIPESTspIIADHLSLIRIIGNLIKNAIHHGKAGKI-VGVE 250
Cdd:PRK10618 514 QDWKPEQELFSLQDLIDEVLPEVLPAIKRKGLQLLIhnhLKAEQL--RIGDRDALRKILLLLLNYAITTTAYGKItLEVD 591
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 251 lLETNTEYELLI--WDKGPGIPKHDLQNVfKRMYRSEHSRNPSYGGSGLGLSISKALVEKNGGRIWVDSIPRERTTFGFS 328
Cdd:PRK10618 592 -QDESSPDRLTIriLDTGAGVSIKELDNL-HFPFLNQTQGDRYGKASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIH 669
|
..
gi 1078691003 329 VP 330
Cdd:PRK10618 670 LK 671
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
226-330 |
2.28e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 62.45 E-value: 2.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 226 LIRIIGNLIKNAIHHgkAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNPSYGGSGLGLSISKAL 305
Cdd:cd16939 1 MARALDNLLRNALRY--AHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*
gi 1078691003 306 VEKNGGRIWVDSIPRERTTFGFSVP 330
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRLTWP 103
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
226-313 |
3.80e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 62.20 E-value: 3.80e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 226 LIRIIGNLIKNAIHHG--KAGKIVgVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYrSEHSRNPSYG-GSGLGLSIS 302
Cdd:cd16953 1 LGQVLRNLIGNAISFSppDTGRIT-VSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSIS 78
|
90
....*....|.
gi 1078691003 303 KALVEKNGGRI 313
Cdd:cd16953 79 RQIIEAHGGIS 89
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
226-330 |
7.99e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 61.15 E-value: 7.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 226 LIRIIGNLIKNAIH----HGKAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEhsrnpSYGGSGLGLSI 301
Cdd:cd16915 1 LITIVGNLIDNALDalaaTGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTK-----GQGERGIGLAL 75
|
90 100
....*....|....*....|....*....
gi 1078691003 302 SKALVEKNGGRIWVDSIPRERTTFGFSVP 330
Cdd:cd16915 76 VRQSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
228-313 |
8.75e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 60.93 E-value: 8.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 228 RIIGNLIKNAIHHGK---------AGKIVGVELLetnteyelliwDKGPGIPKHDLQNVFKRMYRSEHSRNPSygGSGLG 298
Cdd:cd16950 3 RVLSNLVDNALRYGGgwvevssdgEGNRTRIQVL-----------DNGPGIAPEEVDELFQPFYRGDNARGTS--GTGLG 69
|
90
....*....|....*
gi 1078691003 299 LSISKALVEKNGGRI 313
Cdd:cd16950 70 LAIVQRISDAHGGSL 84
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
193-330 |
1.45e-11 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 65.32 E-value: 1.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 193 VLIEFLpeLSKHN------IELQV----LIPESTSP-IIADhlsLIRIIGNLIKNAIH--HGKAGKIVGVELLETNTEYE 259
Cdd:PRK11086 395 VIAGFL--LGKISrarelgITLIIsedsQLPDSGDEdQVHE---LITILGNLIENALEavGGEEGGEISVSLHYRNGWLH 469
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1078691003 260 LLIWDKGPGIPKHDLQNVFKRMYRSEHSrnpsygGSGLGLSISKALVEKNGGRIWVDSIPRERTTFGFSVP 330
Cdd:PRK11086 470 CEVSDDGPGIAPDEIDAIFDKGYSTKGS------NRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
226-330 |
1.48e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 60.49 E-value: 1.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 226 LIRIIGNLIKNAIH--HGKAGKIvgveLLETNTEYELL-------------IWDKGPGIPKHDLQNVFKRMYRSEHsrnp 290
Cdd:cd16918 1 LIQVFLNLVRNAAQalAGSGGEI----ILRTRTQRQVTlghprhrlalrvsVIDNGPGIPPDLQDTIFYPMVSGRE---- 72
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1078691003 291 syGGSGLGLSISKALVEKNGGRIWVDSIPReRTTFGFSVP 330
Cdd:cd16918 73 --NGTGLGLAIAQNIVSQHGGVIECDSQPG-HTVFSVSLP 109
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
222-313 |
1.49e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 60.55 E-value: 1.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 222 DHLSLIRIIGNLIKNAIHHGKAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNpSYGGSGLGLSI 301
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRR-SGGHYGMGLYI 79
|
90
....*....|..
gi 1078691003 302 SKALVEKNGGRI 313
Cdd:cd16975 80 AKNLVEKHGGSL 91
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
226-319 |
1.49e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 57.47 E-value: 1.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 226 LIRIIGNLIKNAIHHGKAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYR--SEHSRNPSyggSGLGLSISK 303
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlpRPHSGQKS---TGLGLAFVQ 81
|
90
....*....|....*.
gi 1078691003 304 ALVEKNGGRIWVDSIP 319
Cdd:cd16945 82 EVAQLHGGRITLRNRP 97
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
226-313 |
1.59e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 57.40 E-value: 1.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 226 LIRIIGNLIKNAIHHGKAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNPsyGGSGLGLSISKAL 305
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNT--EGAGLGLSIAKAI 78
|
....*...
gi 1078691003 306 VEKNGGRI 313
Cdd:cd16923 79 IELHGGSA 86
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
226-330 |
1.81e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 57.30 E-value: 1.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 226 LIRIIGNLIKNAIHHGKAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNpSYGGSGLGLSISKAL 305
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRN-FQESTGMGLYLVKKL 84
|
90 100
....*....|....*....|....*
gi 1078691003 306 VEKNGGRIWVDSIPRERTTFGFSVP 330
Cdd:cd16948 85 CDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
232-330 |
8.00e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 55.51 E-value: 8.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 232 NLIKNAIHH-GKAGKIVgVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEhsrnPSYGGSGLGLSISKALVEKNG 310
Cdd:cd16943 10 NLLVNAAQAmEGRGRIT-IRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTK----PVGEGTGLGLSLSYRIIQKHG 84
|
90 100
....*....|....*....|
gi 1078691003 311 GRIWVDSIPRERTTFGFSVP 330
Cdd:cd16943 85 GTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
226-327 |
2.03e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 54.39 E-value: 2.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 226 LIRIIGNLIKNAIH--HGKAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYrsehSRNPSYGGSGLGLSISK 303
Cdd:cd16976 1 IQQVLMNLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF----TTKPVGKGTGLGLSISY 76
|
90 100
....*....|....*....|....
gi 1078691003 304 ALVEKNGGRIWVDSIPRERTTFGF 327
Cdd:cd16976 77 GIVEEHGGRLSVANEEGAGARFTF 100
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
226-321 |
3.29e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 54.56 E-value: 3.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 226 LIRIIGNLIKNAIHHgkAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNpsygGSGLGLSISKAL 305
Cdd:cd16954 38 LMELLGNLLDNACKW--CLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEI 111
|
90
....*....|....*.
gi 1078691003 306 VEKNGGRIWVDSIPRE 321
Cdd:cd16954 112 VEQYGGELSLSDSPLG 127
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
101-330 |
4.74e-09 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 57.68 E-value: 4.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 101 EARKSQEARKQLLSNISHDIRTPLTSIIGYIDALKDDVATSEVEKqeYLEILYKKSNDLKHLVDEIFNMAKLDADEfpLK 180
Cdd:PRK10841 439 AAEQASQSKSMFLATVSHELRTPLYGIIGNLDLLQTKELPKGVDR--LVTAMNNSSSLLLKIISDILDFSKIESEQ--LK 514
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 181 EEELDFS--EVTREVLIEFLPELSKHNIELQVLIpESTSPII--ADHLSLIRIIGNLIKNAIHHGKAGKIVgVELLETNT 256
Cdd:PRK10841 515 IEPREFSprEVINHITANYLPLVVKKRLGLYCFI-EPDVPVAlnGDPMRLQQVISNLLSNAIKFTDTGCIV-LHVRVDGD 592
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1078691003 257 EYELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNPSYGGSGLGLSISKALVEKNGGRIWVDSIPRERTTFGFSVP 330
Cdd:PRK10841 593 YLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
74-330 |
1.03e-08 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 55.86 E-value: 1.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 74 FTNND---------RSLNNIVFSINELIAALEKGQIEA--RKSQE--------ARKQLLSNISHDIRTPLTSIIGYIDAL 134
Cdd:PRK11073 76 FTDNEvtlvidgrsHILSLTAQRLPEGMILLEMAPMDNqrRLSQEqlqhaqqvAARDLVRGLAHEIKNPLGGLRGAAQLL 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 135 KDdvATSEVEKQEYLEILYKKSNDLKHLVDeifnmaKLDADEFPLKEEELDFSEVTREV--LIEF-LPElskhNIELQVL 211
Cdd:PRK11073 156 SK--ALPDPALTEYTKVIIEQADRLRNLVD------RLLGPQRPGTHVTESIHKVAERVvqLVSLeLPD----NVRLIRD 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 212 IPESTSPIIADHLSLIRIIGNLIKNAIHH-GKAGkivGVELLETNTEYELLIW-------------DKGPGIPKHDLQNV 277
Cdd:PRK11073 224 YDPSLPELAHDPDQIEQVLLNIVRNALQAlGPEG---GTITLRTRTAFQLTLHgeryrlaaridieDNGPGIPPHLQDTL 300
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1078691003 278 FKRMYrSEHSrnpsyGGSGLGLSISKALVEKNGGRIWVDSIPrERTTFGFSVP 330
Cdd:PRK11073 301 FYPMV-SGRE-----GGTGLGLSIARNLIDQHSGKIEFTSWP-GHTEFSVYLP 346
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
31-301 |
1.44e-08 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 55.36 E-value: 1.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 31 SLFI-ALIIITIYLFFSrvhFIQsnesmVTKLSRALKgNLQTRLftnNDRSLNN---------------IVFSINELIAA 94
Cdd:PRK10755 62 SLLVpSLVMVSLTLLIC---FQA-----VRWITRPLA-ELQKEL---EARTADNltpiaihsstleieaVTSALNQLVSR 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 95 LEkgqieARKSQEarKQLLSNISHDIRTPLTSIIGYIDALkddvatsevEKQEYLEI--LYKKSNDLKHLVDEIFNMA-- 170
Cdd:PRK10755 130 LT-----STLDQE--RLFTADVAHELRTPLAGIRLHLELL---------EKQHHIDVapLIARLDQMMHTVEQLLQLAra 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 171 ------------KLDADEFPLKEEELDFSEVTREVlieflpelskhnielQVLIPESTSPIIA--DHLSLIRIIGNLIKN 236
Cdd:PRK10755 194 gqsfssghyqtvKLLEDVILPSQDELSEMLEQRQQ---------------TLLLPESAADITVqgDATLLRLLLRNLVEN 258
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1078691003 237 AIHHGKAGKIVGVELLETNTEYELLIWDKGPGIPK---HDLQNVFKRMyrseHSRnpsYGGSGLGLSI 301
Cdd:PRK10755 259 AHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDEskcGELSKAFVRM----DSR---YGGIGLGLSI 319
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
96-325 |
1.82e-07 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 52.76 E-value: 1.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 96 EKGQIEARKSQEARKQ----LLSNISHDIRTPLTSIIGYIDALKDDVATSEVEKqEYLEILYKKSNDLKHLVDEIFNM-A 170
Cdd:PRK13837 433 ERDALERRLEHARRLEavgtLASGIAHNFNNILGAILGYAEMALNKLARHSRAA-RYIDEIISAGARARLIIDQILAFgR 511
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 171 KLDADEFPLkeeelDFSEVTREV---LIEFLPElskhNIELQVLIPESTSPIIADHLSLIRIIGNLIKNAIHHGKAGKIV 247
Cdd:PRK13837 512 KGERNTKPF-----DLSELVTEIaplLRVSLPP----GVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRV 582
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 248 GVEL----------LETNT----EYELL-IWDKGPGIPKHDLQNVFKRMY--RSehsrnpsyGGSGLGLSISKALVEKNG 310
Cdd:PRK13837 583 DISLsraklrapkvLSHGVlppgRYVLLrVSDTGAGIDEAVLPHIFEPFFttRA--------GGTGLGLATVHGIVSAHA 654
|
250
....*....|....*
gi 1078691003 311 GRIWVDSIPRERTTF 325
Cdd:PRK13837 655 GYIDVQSTVGRGTRF 669
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
5-300 |
3.21e-07 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 51.56 E-value: 3.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 5 KILFLISLQLIICGLLNIDMGYHVKVSLFIALIIITIYLFFSRvhFIQSNESMVTKLSRALKGNLQTRLFTNND------ 78
Cdd:COG2972 138 TLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRS--ITRPIKRLKKAMKKVEKGDLVRLEVSGNDeigila 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 79 RSLNNIVFSINELIAALEKGQIEARKSQeaRKQLLSNIS-HDIRTPLTSIIGYIDaLKDDVATSEvekqeyleILYKKSN 157
Cdd:COG2972 216 RSFNEMVERIKELIEEVYELELEKKEAE--LKALQAQINpHFLFNTLNSIRWLAE-LEDPEEAEE--------MLEALSK 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 158 DLKHLVDEIFNMAKLdadefplkEEELDFseVTREVLIEFLpeLSKHNIELQVLIPEStspiIADHLSLIRIIGNLIKNA 237
Cdd:COG2972 285 LLRYSLSKGDELVTL--------EEELEL--IKSYLEIQKL--RFGDRLEVEIEIDEE----LLDLLIPKLILQPLVENA 348
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1078691003 238 IHHG----KAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHsrnpsygGSGLGLS 300
Cdd:COG2972 349 IEHGiepkEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGE-------GRGIGLR 408
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
90-330 |
4.23e-06 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 47.31 E-value: 4.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 90 ELIAALEKGQIEARksQEARKQLLSNIsHDI---RtpLTSIIGYIDALKDDVATSEVEKQEYLEILykkSNDLKHLVDEI 166
Cdd:COG4585 37 ELERELAARAEEAR--EEERRRIAREL-HDGvgqS--LSAIKLQLEAARRLLDADPEAAREELEEI---RELAREALAEL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 167 FNMAK-LDADEFplkeEELDFSEVTREVLIEFLpelSKHNIELQVLIPESTSPIIADH-LSLIRIIGNLIKNAIHHGKAG 244
Cdd:COG4585 109 RRLVRgLRPPAL----DDLGLAAALEELAERLL---RAAGIRVELDVDGDPDRLPPEVeLALYRIVQEALTNALKHAGAT 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 245 KIVgVELLETNTEYELLIWDKGPGIPKHDLqnvfkrmyrsehsrnpsyGGSGLGLSISKALVEKNGGRIWVDSIPRERTT 324
Cdd:COG4585 182 RVT-VTLEVDDGELTLTVRDDGVGFDPEAA------------------PGGGLGLRGMRERAEALGGTLTIGSAPGGGTR 242
|
....*.
gi 1078691003 325 FGFSVP 330
Cdd:COG4585 243 VRATLP 248
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
111-317 |
7.04e-06 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 47.76 E-value: 7.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 111 QLLSNISHDIRTPLTSIIGYIDALKDDVATSEVEK-QEYLEILYKKSNDLKHLVDEIFNMAKLDADefPLKEEELDFSEV 189
Cdd:COG4192 435 QTMTSLAHELNQPLNAMSMYLFSAKKALEQENYAQlPTSLDKIEGLIERMDKIIKSLRQFSRKSDT--PLQPVDLRQVIE 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 190 TREVLIEflpelSKHNIELQVLIPESTSPIIADHLSLIRIIGNLIKNAIHHGKAGKIVGVELLETNTEYELLIWDKGPGI 269
Cdd:COG4192 513 QAWELVE-----SRAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGW 587
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1078691003 270 PkhDLQNVFKRMYRSEHSrnpsygGSGLGLSISKALVEKNGGRIWVDS 317
Cdd:COG4192 588 P--LVDKLFTPFTTTKEV------GLGLGLSICRSIMQQFGGDLYLAS 627
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
226-330 |
1.65e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 42.54 E-value: 1.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 226 LIRIIGNLIKNAIHHGKAGKIVgVELLETNTEYELLIWDKGPGIPKHdlqnvfkrmyrsehsrnPSYGGSGLGLSISKAL 305
Cdd:cd16917 1 LYRIVQEALTNALKHAGASRVR-VTLSYTADELTLTVVDDGVGFDGP-----------------APPGGGGFGLLGMRER 62
|
90 100
....*....|....*....|....*
gi 1078691003 306 VEKNGGRIWVDSIPRERTTFGFSVP 330
Cdd:cd16917 63 AELLGGTLTIGSRPGGGTRVTARLP 87
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
236-306 |
2.46e-05 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 43.36 E-value: 2.46e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1078691003 236 NAIHHG---KAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNvfkrmyrsehsRNPSYGGSGLGLSISKALV 306
Cdd:COG2172 45 NAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPD-----------PYSTLAEGGRGLFLIRRLM 107
|
|
| PRK14868 |
PRK14868 |
DNA topoisomerase VI subunit B; Provisional |
249-300 |
1.25e-04 |
|
DNA topoisomerase VI subunit B; Provisional
Pssm-ID: 237842 [Multi-domain] Cd Length: 795 Bit Score: 43.64 E-value: 1.25e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1078691003 249 VELLETNTEYELLIWDKGPGIPKHDLQNVF-KRMYRSE-HSRNPSYGGSGLGLS 300
Cdd:PRK14868 73 VEIEEVGDYYRLVVEDNGPGITKEQIPKVFgKLLYGSRfHAREQSRGQQGIGIS 126
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
182-330 |
4.78e-04 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 41.81 E-value: 4.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 182 EELDFSEVTREVLIEFLPELSKHNIELQVLIPEST-SPIIADHLSLIriIGNLIKNAIHHG----KAGKIVgVELLETNT 256
Cdd:COG3920 357 EGVDLRDYLRELLEPLRDSYGGRGIRIELDGPDVElPADAAVPLGLI--LNELVTNALKHAflsgEGGRIR-VSWRREDG 433
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1078691003 257 EYELLIWDKGPGIPKH-DLQNvfkrmyrsehsrnpsygGSGLGLSISKALVEKNGGRIWVDSipRERTTFGFSVP 330
Cdd:COG3920 434 RLRLTVSDNGVGLPEDvDPPA-----------------RKGLGLRLIRALVRQLGGTLELDR--PEGTRVRITFP 489
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
229-313 |
4.95e-04 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 41.54 E-value: 4.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 229 IIGNLIKNAIHHgkAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRMYRSEHSRNpsygGSGLGLSISKALVEK 308
Cdd:PRK10815 382 VMGNVLDNACKY--CLEFVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQ 455
|
....*
gi 1078691003 309 NGGRI 313
Cdd:PRK10815 456 YEGKI 460
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
264-330 |
1.39e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 38.13 E-value: 1.39e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1078691003 264 DKGPGIPKHDLQNVFKRMYrsehSRNPSYGGSGLGLSISKALVEKNGGRIWVDSIPRERTTFGFSVP 330
Cdd:cd16919 54 DTGSGMPAEVLRRAFEPFF----TTKEVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
232-313 |
1.47e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 37.90 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 232 NLIKNA---IHHGKAGKIVGVELLETNTEYE--LLIWDKGPGIPKHDLQNVFKRmYRSEHSRnpsygGSGLGLSISKALV 306
Cdd:cd16944 11 NILKNAaeaIEGRPSDVGEVRIRVEADQDGRivLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GTGLGLAIVKKIM 84
|
....*..
gi 1078691003 307 EKNGGRI 313
Cdd:cd16944 85 EEHGGRI 91
|
|
| HATPase_TopVIB-like |
cd16933 |
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ... |
225-300 |
2.57e-03 |
|
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.
Pssm-ID: 340410 [Multi-domain] Cd Length: 203 Bit Score: 38.48 E-value: 2.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 225 SLIRIIGNLIKNAIHHGKAGKI---VGVELLETNTE-YELLIWDKGPGIPKHDLQNVFKRM-YRSEHSRNPSYGGSGLGL 299
Cdd:cd16933 19 SLYTTVRELVENSLDATEEAGIlpdIKVEIEEIGKDhYKVIVEDNGPGIPEEQIPKVFGKVlYGSKYHNKQSRGQQGLGI 98
|
.
gi 1078691003 300 S 300
Cdd:cd16933 99 S 99
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
210-319 |
2.93e-03 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 38.09 E-value: 2.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 210 VLIPESTSPI----IADHLSLIriIGNLIKNAI-----HHGKAGKI---VGVELLETNTEYELLIWDKGPGIPKHDLQNV 277
Cdd:cd16929 26 ELEIEGDPSIrfpyVPSHLYYI--LFELLKNAMratveSHGDDSDDlppIKVTVAKGDEDLTIKISDRGGGIPREDLARL 103
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1078691003 278 FKRMYRSehSRNPSY---------------GGSGLGLSISKALVEKNGGRIWVDSIP 319
Cdd:cd16929 104 FSYMYST--APQPSLddfsdlisgtqpsplAGFGYGLPMSRLYAEYFGGDLDLQSME 158
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
222-331 |
6.32e-03 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 38.28 E-value: 6.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078691003 222 DHLSLIRIIGNLIKNA----IHHGKAGKIVGVELLETNTEYELLIWDKGPGIPKHDLQNVFKRmyrSEHSRNPSYGGSGL 297
Cdd:PRK15053 429 DSTEFAAIVGNLLDNAfeasLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQ---GVSTRADEPGEHGI 505
|
90 100 110
....*....|....*....|....*....|....
gi 1078691003 298 GLSISKALVEKNGGRIWVDSIPRERTTFGFSVPK 331
Cdd:PRK15053 506 GLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPK 539
|
|
| |
