type VI secretion system tip protein VgrG is a core component and effector of Type VI secretion systems (T6SSs) that are involved in the pathogenicity of several Gram-negative bacteria
type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs ...
13-525
0e+00
type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs element Vgr protein family (see TIGR01646), but furthermore all are found in genomes with type VI secretion loci. However, members of this protein family, although recognizably correlated to type VI secretion according the partial phylogenetic profiling algorithm, are often found far the type VI secretion locus.
:
Pssm-ID: 274542 [Multi-domain] Cd Length: 513 Bit Score: 685.09 E-value: 0e+00
type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs ...
13-525
0e+00
type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs element Vgr protein family (see TIGR01646), but furthermore all are found in genomes with type VI secretion loci. However, members of this protein family, although recognizably correlated to type VI secretion according the partial phylogenetic profiling algorithm, are often found far the type VI secretion locus.
Pssm-ID: 274542 [Multi-domain] Cd Length: 513 Bit Score: 685.09 E-value: 0e+00
Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly ...
1-525
0e+00
Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly [Intracellular trafficking, secretion, and vesicular transport, Mobilome: prophages, transposons, General function prediction only];
Pssm-ID: 442724 [Multi-domain] Cd Length: 743 Bit Score: 656.45 E-value: 0e+00
Phage tail baseplate hub (GPD); This family includes a number of phage late expression gene D ...
42-335
2.26e-87
Phage tail baseplate hub (GPD); This family includes a number of phage late expression gene D proteins and related bacterial sequences. This family also includes Bacteriophage Mu P proteins and related sequences. This protein forms the phage central baseplate hub.
Pssm-ID: 428689 Cd Length: 302 Bit Score: 271.11 E-value: 2.26e-87
VgrG-related protein; Members of this family resemble Vgr proteins of type VI secretion ...
363-465
8.57e-09
VgrG-related protein; Members of this family resemble Vgr proteins of type VI secretion systems (T6SS) as found in various proteobacteria. However, members of this family occur instead in genera such as Streptomyces and Roseiflexus. The biological roles and molecular functions of proteins in this family appear not to have been characterized.
Pssm-ID: 468205 [Multi-domain] Cd Length: 547 Bit Score: 58.00 E-value: 8.57e-09
type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs ...
13-525
0e+00
type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs element Vgr protein family (see TIGR01646), but furthermore all are found in genomes with type VI secretion loci. However, members of this protein family, although recognizably correlated to type VI secretion according the partial phylogenetic profiling algorithm, are often found far the type VI secretion locus.
Pssm-ID: 274542 [Multi-domain] Cd Length: 513 Bit Score: 685.09 E-value: 0e+00
Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly ...
1-525
0e+00
Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly [Intracellular trafficking, secretion, and vesicular transport, Mobilome: prophages, transposons, General function prediction only];
Pssm-ID: 442724 [Multi-domain] Cd Length: 743 Bit Score: 656.45 E-value: 0e+00
Rhs element Vgr protein; This model represents the Vgr family of proteins, associated with ...
18-508
1.77e-142
Rhs element Vgr protein; This model represents the Vgr family of proteins, associated with some classes of Rhs elements. This model does not include a large octapeptide repeat region, VGXXXXXX, found in the Vgr of Rhs classes G and E.
Pssm-ID: 273730 [Multi-domain] Cd Length: 483 Bit Score: 419.19 E-value: 1.77e-142
Phage tail baseplate hub (GPD); This family includes a number of phage late expression gene D ...
42-335
2.26e-87
Phage tail baseplate hub (GPD); This family includes a number of phage late expression gene D proteins and related bacterial sequences. This family also includes Bacteriophage Mu P proteins and related sequences. This protein forms the phage central baseplate hub.
Pssm-ID: 428689 Cd Length: 302 Bit Score: 271.11 E-value: 2.26e-87
Type VI secretion system/phage-baseplate injector OB domain; Family of bacterial and phage ...
394-455
7.02e-13
Type VI secretion system/phage-baseplate injector OB domain; Family of bacterial and phage baseplate assembly proteins responsible for forming the small spike at the end of the tail or bacterial pathogenic needle-shaft. This entry represents the OB fold part of the structure. This structure contains an unusual extra beta hairpin that forms the foundation of the spike protein's beta helix.
Pssm-ID: 428084 [Multi-domain] Cd Length: 75 Bit Score: 63.75 E-value: 7.02e-13
VgrG-related protein; Members of this family resemble Vgr proteins of type VI secretion ...
363-465
8.57e-09
VgrG-related protein; Members of this family resemble Vgr proteins of type VI secretion systems (T6SS) as found in various proteobacteria. However, members of this family occur instead in genera such as Streptomyces and Roseiflexus. The biological roles and molecular functions of proteins in this family appear not to have been characterized.
Pssm-ID: 468205 [Multi-domain] Cd Length: 547 Bit Score: 58.00 E-value: 8.57e-09
Domain of unknown function (DUF6484); This domain of unknown function is found in ...
435-456
2.55e-03
Domain of unknown function (DUF6484); This domain of unknown function is found in uncharacterized proteins from Proteobacteria. This domain is approximately 80 amino acids in length and exhibits overlaps with pfam04717, which suggests that it has an OB fold and, thus, it belongs to the same clan. Many proteins containing this domain are related to the Type VI secretion system and to Phage-related baseplate proteins.
Pssm-ID: 466287 [Multi-domain] Cd Length: 61 Bit Score: 36.39 E-value: 2.55e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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Domains are color coded according to superfamilies
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
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the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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