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Conserved domains on  [gi|1080454509|gb|OFM38394|]
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phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating) [Neisseria sp. HMSC058F07]

Protein Classification

NADP(+)-dependent, decarboxylating phosphogluconate dehydrogenase( domain architecture ID 11417508)

NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate, as part of the oxidative branch of the pentose phosphate pathway

CATH:  3.40.50.720|1.20.5.320
EC:  1.1.1.44
Gene Ontology:  GO:0004616|GO:0050661|GO:0006098|GO:0046177
PubMed:  35234135|34709178|26479318
SCOP:  3000048

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 1-468 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


:

Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 916.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509   1 MKGDIGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDDFLNGAAKNTNIIGAYSLQDLVNKLEKPRKIMMMVRAGSVV 80
Cdd:COG0362     1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509  81 DDFIEQLVPLLDQGDIIIDGGNANYPDSTRRTHELAAKGIRFIGAGVSGGEEGARHGPSIMPGGDEAVWPAVKPIFQAIS 160
Cdd:COG0362    81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 161 AKTpQGEPCCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHQIFNEWNKTELDSYLVEITAAILG 240
Cdd:COG0362   161 AKV-DGEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 241 YRD-ENGEPLVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSAFKDQRTQANSLF-GKTITPIEGDKAAWV 318
Cdd:COG0362   240 KKDpETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLpGPEAAPFEGDKEAFI 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 319 EALRQALLASKIISYAQGFMLIREASENNDWALNYGNTALLWREGCIIRSAFLGNIRDAYEANPDLVFLGSDPYFKGVLE 398
Cdd:COG0362   320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 399 ICLPAWRKVVAKAIECGIPMPCMASAITFLDGYTSERLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNW 468
Cdd:COG0362   400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEG--FFHTEW 467
 
Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 1-468 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 916.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509   1 MKGDIGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDDFLNGAAKNTNIIGAYSLQDLVNKLEKPRKIMMMVRAGSVV 80
Cdd:COG0362     1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509  81 DDFIEQLVPLLDQGDIIIDGGNANYPDSTRRTHELAAKGIRFIGAGVSGGEEGARHGPSIMPGGDEAVWPAVKPIFQAIS 160
Cdd:COG0362    81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 161 AKTpQGEPCCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHQIFNEWNKTELDSYLVEITAAILG 240
Cdd:COG0362   161 AKV-DGEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 241 YRD-ENGEPLVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSAFKDQRTQANSLF-GKTITPIEGDKAAWV 318
Cdd:COG0362   240 KKDpETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLpGPEAAPFEGDKEAFI 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 319 EALRQALLASKIISYAQGFMLIREASENNDWALNYGNTALLWREGCIIRSAFLGNIRDAYEANPDLVFLGSDPYFKGVLE 398
Cdd:COG0362   320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 399 ICLPAWRKVVAKAIECGIPMPCMASAITFLDGYTSERLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNW 468
Cdd:COG0362   400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEG--FFHTEW 467
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
13-472 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 895.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509  13 MGQNLILNMNDNGFKVVAYNRTTSKVDDFLNGAAKNTNIIGAYSLQDLVNKLEKPRKIMMMVRAGSVVDDFIEQLVPLLD 92
Cdd:PRK09287    1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAEEGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509  93 QGDIIIDGGNANYPDSTRRTHELAAKGIRFIGAGVSGGEEGARHGPSIMPGGDEAVWPAVKPIFQAISAKTPQGEPCCDW 172
Cdd:PRK09287   81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 173 VGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHQIFNEWNKTELDSYLVEITAAILGYRD-ENGEPLVE 251
Cdd:PRK09287  161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDeETGKPLVD 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 252 KILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSAFKDQRTQANSLFGKTITPIEGDKAAWVEALRQALLASKII 331
Cdd:PRK09287  241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAAKFEGDKAEFIEDVRQALYASKIV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 332 SYAQGFMLIREASENNDWALNYGNTALLWREGCIIRSAFLGNIRDAYEANPDLVFLGSDPYFKGVLEICLPAWRKVVAKA 411
Cdd:PRK09287  321 SYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVALA 400

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1080454509 412 IECGIPMPCMASAITFLDGYTSERLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNWTGKG 472
Cdd:PRK09287  401 VQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEG--FFHTEWSEDG 459
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 4-470 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 871.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509   4 DIGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDDFLNGAAKNTNIIGAYSLQDLVNKLEKPRKIMMMVRAGSVVDDF 83
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEFLAEEAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509  84 IEQLVPLLDQGDIIIDGGNANYPDSTRRTHELAAKGIRFIGAGVSGGEEGARHGPSIMPGGDEAVWPAVKPIFQAISAKT 163
Cdd:TIGR00873  81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 164 pQGEPCCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHQIFNEWNKTELDSYLVEITAAILGYRD 243
Cdd:TIGR00873 161 -DGEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 244 ENGEPLVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSAFKDQRTQANSLFGKTITPIEG-DKAAWVEALR 322
Cdd:TIGR00873 240 EDGNPLVDKILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPEAPKKGvDKEEFIEDVR 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 323 QALLASKIISYAQGFMLIREASENNDWALNYGNTALLWREGCIIRSAFLGNIRDAYEANPDLVFLGSDPYFKGVLEICLP 402
Cdd:TIGR00873 320 QALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQS 399

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1080454509 403 AWRKVVAKAIECGIPMPCMASAITFLDGYTSERLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTG 470
Cdd:TIGR00873 400 GWRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTG 467
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 179-468 0e+00

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 545.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 179 GHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHQIFNEWNKTELDSYLVEITAAILGYRDEN-GEPLVEKILDTA 257
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDPEdGKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 258 GQKGTGKWTGINALDLGIPLTLISEAVFARCVSAFKDQRTQANSLF-GKTITPIEGDKAAWVEALRQALLASKIISYAQG 336
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLpGPPPALFEGDKEAFIEDLRQALYASKIISYAQG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 337 FMLIREASENNDWALNYGNTALLWREGCIIRSAFLGNIRDAYEANPDLVFLGSDPYFKGVLEICLPAWRKVVAKAIECGI 416
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1080454509 417 PMPCMASAITFLDGYTSERLPANLLQAQRDYFGAHTYERTDKprGEFFHTNW 468
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDK--EGFFHTEW 290
 
Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 1-468 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 916.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509   1 MKGDIGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDDFLNGAAKNTNIIGAYSLQDLVNKLEKPRKIMMMVRAGSVV 80
Cdd:COG0362     1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509  81 DDFIEQLVPLLDQGDIIIDGGNANYPDSTRRTHELAAKGIRFIGAGVSGGEEGARHGPSIMPGGDEAVWPAVKPIFQAIS 160
Cdd:COG0362    81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 161 AKTpQGEPCCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHQIFNEWNKTELDSYLVEITAAILG 240
Cdd:COG0362   161 AKV-DGEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 241 YRD-ENGEPLVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSAFKDQRTQANSLF-GKTITPIEGDKAAWV 318
Cdd:COG0362   240 KKDpETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLpGPEAAPFEGDKEAFI 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 319 EALRQALLASKIISYAQGFMLIREASENNDWALNYGNTALLWREGCIIRSAFLGNIRDAYEANPDLVFLGSDPYFKGVLE 398
Cdd:COG0362   320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 399 ICLPAWRKVVAKAIECGIPMPCMASAITFLDGYTSERLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNW 468
Cdd:COG0362   400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEG--FFHTEW 467
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
13-472 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 895.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509  13 MGQNLILNMNDNGFKVVAYNRTTSKVDDFLNGAAKNTNIIGAYSLQDLVNKLEKPRKIMMMVRAGSVVDDFIEQLVPLLD 92
Cdd:PRK09287    1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAEEGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509  93 QGDIIIDGGNANYPDSTRRTHELAAKGIRFIGAGVSGGEEGARHGPSIMPGGDEAVWPAVKPIFQAISAKTPQGEPCCDW 172
Cdd:PRK09287   81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 173 VGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHQIFNEWNKTELDSYLVEITAAILGYRD-ENGEPLVE 251
Cdd:PRK09287  161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDeETGKPLVD 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 252 KILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSAFKDQRTQANSLFGKTITPIEGDKAAWVEALRQALLASKII 331
Cdd:PRK09287  241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAAKFEGDKAEFIEDVRQALYASKIV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 332 SYAQGFMLIREASENNDWALNYGNTALLWREGCIIRSAFLGNIRDAYEANPDLVFLGSDPYFKGVLEICLPAWRKVVAKA 411
Cdd:PRK09287  321 SYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVALA 400

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1080454509 412 IECGIPMPCMASAITFLDGYTSERLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNWTGKG 472
Cdd:PRK09287  401 VQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEG--FFHTEWSEDG 459
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 4-470 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 871.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509   4 DIGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDDFLNGAAKNTNIIGAYSLQDLVNKLEKPRKIMMMVRAGSVVDDF 83
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEFLAEEAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509  84 IEQLVPLLDQGDIIIDGGNANYPDSTRRTHELAAKGIRFIGAGVSGGEEGARHGPSIMPGGDEAVWPAVKPIFQAISAKT 163
Cdd:TIGR00873  81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 164 pQGEPCCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHQIFNEWNKTELDSYLVEITAAILGYRD 243
Cdd:TIGR00873 161 -DGEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 244 ENGEPLVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSAFKDQRTQANSLFGKTITPIEG-DKAAWVEALR 322
Cdd:TIGR00873 240 EDGNPLVDKILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPEAPKKGvDKEEFIEDVR 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 323 QALLASKIISYAQGFMLIREASENNDWALNYGNTALLWREGCIIRSAFLGNIRDAYEANPDLVFLGSDPYFKGVLEICLP 402
Cdd:TIGR00873 320 QALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQS 399

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1080454509 403 AWRKVVAKAIECGIPMPCMASAITFLDGYTSERLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTG 470
Cdd:TIGR00873 400 GWRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTG 467
PTZ00142 PTZ00142
6-phosphogluconate dehydrogenase; Provisional
 2-469 0e+00

6-phosphogluconate dehydrogenase; Provisional


Pssm-ID: 240287 [Multi-domain]  Cd Length: 470  Bit Score: 668.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509   2 KGDIGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDDFLNGAAK-NTNIIGAYSLQDLVNKLEKPRKIMMMVRAGSVV 80
Cdd:PTZ00142    1 MSDIGLIGLAVMGQNLALNIASRGFKISVYNRTYEKTEEFVKKAKEgNTRVKGYHTLEELVNSLKKPRKVILLIKAGEAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509  81 DDFIEQLVPLLDQGDIIIDGGNANYPDSTRRTHELAAKGIRFIGAGVSGGEEGARHGPSIMPGGDEAVWPAVKPIFQAIS 160
Cdd:PTZ00142   81 DETIDNLLPLLEKGDIIIDGGNEWYLNTERRIKRCEEKGILYLGMGVSGGEEGARYGPSLMPGGNKEAYDHVKDILEKCS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 161 AKTpQGEPCCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHQIFNEWNKTELDSYLVEITAAILG 240
Cdd:PTZ00142  161 AKV-GDSPCVTYVGPGSSGHYVKMVHNGIEYGDMQLISESYKLMKHILGMSNEELSEVFNKWNEGILNSYLIEITAKILA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 241 YRDENGE-PLVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSAFKDQRTQANSLF---GKTITPIEGDKAA 316
Cdd:PTZ00142  240 KKDDLGEeHLVDKILDIAGSKGTGKWTVQEALERGIPVPTMAASVDARNISALKEERTKASSHLagpNPANKTETEDKKY 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 317 WVEALRQALLASKIISYAQGFMLIREASENNDWALNYGNTALLWREGCIIRSAFLGNIRDAYEANPDLVFLGSDPYFKGV 396
Cdd:PTZ00142  320 FIDDLKNALYCSKIISYTQGFFLIKEASKEFGWNLNLGEIARIWRGGCIIRAVFLDRIKNAFKKNPQLDLLFLDPDFNDE 399

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1080454509 397 LEICLPAWRKVVAKAIECGIPMPCMASAITFLDGYTSERLPANLLQAQRDYFGAHTYERTDKPRGefFHTNWT 469
Cdd:PTZ00142  400 LKNKQPSWRKVVSMATKNGIPTPAFSASLAYYQMYRSQNLPANLVQAQRDYFGAHTYKRLDRPGA--FHTNWE 470
PLN02350 PLN02350
phosphogluconate dehydrogenase (decarboxylating)
 1-480 0e+00

phosphogluconate dehydrogenase (decarboxylating)


Pssm-ID: 215200 [Multi-domain]  Cd Length: 493  Bit Score: 570.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509   1 MKGDIGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDDFLNGAAK--NTNIIGAYSLQDLVNKLEKPRKIMMMVRAGS 78
Cdd:PLN02350    5 ALSRIGLAGLAVMGQNLALNIAEKGFPISVYNRTTSKVDETVERAKKegNLPLYGFKDPEDFVLSIQKPRSVIILVKAGA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509  79 VVDDFIEQLVPLLDQGDIIIDGGNANYPDSTRRTHELAAKGIRFIGAGVSGGEEGARHGPSIMPGGDEAVWPAVKPIFQA 158
Cdd:PLN02350   85 PVDQTIKALSEYMEPGDCIIDGGNEWYENTERRIKEAAEKGLLYLGMGVSGGEEGARNGPSLMPGGSFEAYKNIEDILEK 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 159 ISAKTPQGePCCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHQIFNEWNKTELDSYLVEITAAI 238
Cdd:PLN02350  165 VAAQVDDG-PCVTYIGPGGAGNFVKMVHNGIEYGDMQLISEAYDVLKSVGGLSNEELAEVFAEWNKGELESFLIEITADI 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 239 LGYRDENGE-PLVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSAFKDQRTQANSLFGK------TITPIE 311
Cdd:PLN02350  244 FSVKDDKGDgYLVDKILDKTGMKGTGKWTVQQAAELSVAAPTIAASLDARYLSGLKEERVAAAKVFKEaglediLSADSG 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 312 GDKAAWVEALRQALLASKIISYAQGFMLIREASENNDWALNYGNTALLWREGCIIRSAFLGNIRDAYEANPDLVFLGSDP 391
Cdd:PLN02350  324 VDKKQLIDDVRQALYASKICSYAQGMNLIRAKSVEKGWNLNLGELARIWKGGCIIRAVFLDRIKKAYDRNPDLASLLVDP 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 392 YFKGVLEICLPAWRKVVAKAIECGIPMPCMASAITFLDGYTSERLPANLLQAQRDYFGAHTYERTDKPrgEFFHTNWT-- 469
Cdd:PLN02350  404 EFAKEMVERQAAWRRVVSLAINAGISTPGMSASLAYFDTYRRARLPANLVQAQRDYFGAHTYERVDRP--GSFHTEWTkl 481

                         490
                  ....*....|..
gi 1080454509 470 -GKGGDTASTTY 480
Cdd:PLN02350  482 aRKSKIITGRTA 493
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 179-468 0e+00

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 545.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 179 GHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHQIFNEWNKTELDSYLVEITAAILGYRDEN-GEPLVEKILDTA 257
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDPEdGKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 258 GQKGTGKWTGINALDLGIPLTLISEAVFARCVSAFKDQRTQANSLF-GKTITPIEGDKAAWVEALRQALLASKIISYAQG 336
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLpGPPPALFEGDKEAFIEDLRQALYASKIISYAQG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 337 FMLIREASENNDWALNYGNTALLWREGCIIRSAFLGNIRDAYEANPDLVFLGSDPYFKGVLEICLPAWRKVVAKAIECGI 416
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1080454509 417 PMPCMASAITFLDGYTSERLPANLLQAQRDYFGAHTYERTDKprGEFFHTNW 468
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDK--EGFFHTEW 290
YqeC COG1023
6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];
1-287 6.75e-92

6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];


Pssm-ID: 440646 [Multi-domain]  Cd Length: 300  Bit Score: 281.21  E-value: 6.75e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509   1 MKgdIGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDdflngAAKNTNIIGAYSLQDLVNKLEKPRKIMMMVRAGSVV 80
Cdd:COG1023     1 MQ--IGMIGLGKMGGNMARRLLRHGHEVVGYDRNPEAVA-----ALAAEGATGADSLEELVAKLPAPRVVWLMVPAGEIT 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509  81 DDFIEQLVPLLDQGDIIIDGGNANYPDSTRRTHELAAKGIRFIGAGVSGGEEGARHGPSIMPGGDEAVWPAVKPIFQAIS 160
Cdd:COG1023    74 DQVIEELAPLLEPGDIVIDGGNSNYKDDIRRAEELAEKGIHFVDVGTSGGVWGLENGYCLMIGGDKEAVERLEPIFKALA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 161 AKTPQGepcCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGlGLSYDeMHQIFNEWNK-TELDSYLVEITAAIL 239
Cdd:COG1023   154 PGAENG---YLHCGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEAS-EFDLD-LAEVAEVWRRgSVIRSWLLDLTADAL 228

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1080454509 240 gyrDENGEplVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFAR 287
Cdd:COG1023   229 ---AEDPK--LEGISGYVEDSGEGRWTVEEAIELGVPAPVITAALFAR 271
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
1-287 4.25e-91

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 279.33  E-value: 4.25e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509   1 MKgdIGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDdflngAAKNTNIIGAYSLQDLVNKLEKPRKIMMMVRAGSVV 80
Cdd:PRK09599    1 MQ--LGMIGLGRMGGNMARRLLRGGHEVVGYDRNPEAVE-----ALAEEGATGADSLEELVAKLPAPRVVWLMVPAGEIT 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509  81 DDFIEQLVPLLDQGDIIIDGGNANYPDSTRRTHELAAKGIRFIGAGVSGGEEGARHGPSIMPGGDEAVWPAVKPIFQAIS 160
Cdd:PRK09599   74 DATIDELAPLLSPGDIVIDGGNSYYKDDIRRAELLAEKGIHFVDVGTSGGVWGLERGYCLMIGGDKEAVERLEPIFKALA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 161 AKTPQGepccdWV--GRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGlGLSYDeMHQIFNEWNK-TELDSYLVEITAA 237
Cdd:PRK09599  154 PRAEDG-----YLhaGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEAS-RFDLD-LAAVAEVWRRgSVIRSWLLDLTAD 226

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1080454509 238 ILGyrdenGEPLVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFAR 287
Cdd:PRK09599  227 ALA-----EDPKLDEISGYVEDSGEGRWTVEEAIDLAVPAPVIAAALFMR 271
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 4-174 6.81e-65

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 206.55  E-value: 6.81e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509   4 DIGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDDFLNgaaknTNIIGAYSLQDLVNKLekpRKIMMMVRAGSVVDDF 83
Cdd:pfam03446   1 KIGFIGLGVMGSPMALNLLKAGYTVTVYNRTPEKVEELVA-----AGAIAAASPAEFVAGL---DVVITMVPAGAAVDAV 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509  84 IEQ--LVPLLDQGDIIIDGGNANYPDSTRRTHELAAKGIRFIGAGVSGGEEGARHGP-SIMPGGDEAVWPAVKPIFQAIS 160
Cdd:pfam03446  73 IFGegLLPGLKPGDIIIDGSTSSPEDARRRAKELKEKGLHFLDAPVSGGEAGAENGTlSIMVGGDEEAFERVKPILEAMG 152

                         170
                  ....*....|....
gi 1080454509 161 AktpqgepCCDWVG 174
Cdd:pfam03446 153 A-------CVTYIG 159
gnd_rel TIGR00872
6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) ...
 5-294 9.49e-56

6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) of bacterial and eukaryotic 6-phosphogluconate dehydrogenases but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. Among complete genomes, it is found is found in Bacillus subtilis and Mycobacterium tuberculosis, both of which also contain gnd, and in Aquifex aeolicus. The protein from Methylobacillus flagellatus KT has been characterized as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle. In some sequenced organisms members of this family are the sole 6-phosphogluconate dehydrogenase present and are probably active in the pentose phosphate cycle. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273313 [Multi-domain]  Cd Length: 298  Bit Score: 187.75  E-value: 9.49e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509   5 IGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDdflngAAKNTNIIGAYSLQDLVNKLEKPRKIMMMVRAGsVVDDFI 84
Cdd:TIGR00872   3 LGLIGLGRMGANIVRRLAKRGHDCVGYDHDQDAVK-----AMKEDRTTGVANLRELSQRLSAPRVVWVMVPHG-IVDAVL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509  85 EQLVPLLDQGDIIIDGGNANYPDSTRRTHELAAKGIRFIGAGVSGGEEGARHGPSIMPGGDEAVWPAVKPIFQAIsAKTP 164
Cdd:TIGR00872  77 EELAPTLEKGDIVIDGGNSYYKDSLRRYKLLKEKGIHLLDCGTSGGVWGRERGYCFMIGGDGEAFARAEPLFADV-APEE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509 165 QGEPCCdwvGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGlglSYD-EMHQIFNEWNK-TELDSYLVEITAaiLGYR 242
Cdd:TIGR00872 156 QGYLYC---GPCGSGHFVKMVHNGIEYGMMAAIAEGFEILRNS---QFDfDIPEVARVWRRgSVIRSWLLDLTA--IAFR 227

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1080454509 243 DENGEPLVEKILDTAGQkgtGKWTGINALDLGIPLTLISEAVFARCVSAFKD 294
Cdd:TIGR00872 228 ESPDLAEFSGRVSDSGE---GRWTVIAAIDLGVPAPVIATSLQSRFASRDLD 276
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 5-222 1.12e-29

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 117.52  E-value: 1.12e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509   5 IGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDDFLNGAAKntniiGAYSLQDLVNKLEkprKIMMMVRAGSVVDDFI 84
Cdd:COG2084     4 VGFIGLGAMGAPMARNLLKAGHEVTVWNRTPAKAEALVAAGAR-----VAASPAEAAAAAD---VVITMLPDDAAVEEVL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509  85 ---EQLVPLLDQGDIIIDGGNANyPDSTRRTHE-LAAKGIRFIGAGVSGGEEGARHGP-SIMPGGDEAVWPAVKPIFQAI 159
Cdd:COG2084    76 lgeDGLLAALRPGAVVVDMSTIS-PETARELAAaAAARGVRYLDAPVSGGPAGAEAGTlTIMVGGDEAAFERARPVLEAM 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1080454509 160 SAKTpqgepccDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDgLGLSYDEMHQIFNEW 222
Cdd:COG2084   155 GKRI-------VHVGDAGAGQAAKLANNLLLAGTMAALAEALALAEK-AGLDPETLLEVLSGG 209
garR PRK11559
tartronate semialdehyde reductase; Provisional
 1-184 1.10e-16

tartronate semialdehyde reductase; Provisional


Pssm-ID: 183197 [Multi-domain]  Cd Length: 296  Bit Score: 80.48  E-value: 1.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509   1 MKGDIGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDDFLNGAAKntniiGAYSLQDLVnklEKPRKIMMMVRAGSVV 80
Cdd:PRK11559    1 MTMKVGFIGLGIMGKPMSKNLLKAGYSLVVYDRNPEAVAEVIAAGAE-----TASTAKAVA---EQCDVIITMLPNSPHV 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509  81 DDFI---EQLVPLLDQGDIIIDGGNANyPDSTRRTH-ELAAKGIRFIGAGVSGGEEGARHGP-SIMPGGDEAVWPAVKPI 155
Cdd:PRK11559   73 KEVAlgeNGIIEGAKPGTVVIDMSSIA-PLASREIAaALKAKGIEMLDAPVSGGEPKAIDGTlSVMVGGDKAIFDKYYDL 151

                         170       180
                  ....*....|....*....|....*....
gi 1080454509 156 FQAISAKTPQgepccdwVGRDGAGHFVKM 184
Cdd:PRK11559  152 MKAMAGSVVH-------TGDIGAGNVTKL 173
PRK15059 PRK15059
2-hydroxy-3-oxopropionate reductase;
5-203 3.17e-10

2-hydroxy-3-oxopropionate reductase;


Pssm-ID: 185019 [Multi-domain]  Cd Length: 292  Bit Score: 61.19  E-value: 3.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509   5 IGVIGLAVMGQNLILNMNDNGFKVvaYNRTTSKVDDFLNGaakntniIGAYSLQDLVNKLEKPRKIMMMVRAGSVVDDFI 84
Cdd:PRK15059    3 LGFIGLGIMGTPMAINLARAGHQL--HVTTIGPVADELLS-------LGAVSVETARQVTEASDIIFIMVPDTPQVEEVL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509  85 ---EQLVPLLDQGDIIIDGGNANYPDSTRRTHELAAKGIRFIGAGVSGGEEGARHGP-SIMPGGDEAVWPAVKPIFQAIS 160
Cdd:PRK15059   74 fgeNGCTKASLKGKTIVDMSSISPIETKRFARQVNELGGDYLDAPVSGGEIGAREGTlSIMVGGDEAVFERVKPLFELLG 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1080454509 161 AKTpqgepccDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQF 203
Cdd:PRK15059  154 KNI-------TLVGGNGDGQTCKVANQIIVALNIEAVSEALLF 189
PLN02858 PLN02858
fructose-bisphosphate aldolase
 5-186 1.21e-03

fructose-bisphosphate aldolase


Pssm-ID: 215463 [Multi-domain]  Cd Length: 1378  Bit Score: 41.76  E-value: 1.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509    5 IGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDDFLN--GAAKNTNIIGAYSLQDLVnklekprkimMMVRAGSVVDD 82
Cdd:PLN02858   327 IGFIGLGAMGFGMASHLLKSNFSVCGYDVYKPTLVRFENagGLAGNSPAEVAKDVDVLV----------IMVANEVQAEN 396

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080454509   83 FI---EQLVPLLDQGDIIIDGGNAN--YPDSTRRTHELAAKGIRFIGAGVSGGEEGARHGP-SIMPGG-DEAVWPAvKPI 155
Cdd:PLN02858   397 VLfgdLGAVSALPAGASIVLSSTVSpgFVIQLERRLENEGRDIKLVDAPVSGGVKRAAMGTlTIMASGtDEALKSA-GSV 475

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1080454509  156 FQAISAKTPQGEPCCdwvgrdGAGHFVKMVH 186
Cdd:PLN02858   476 LSALSEKLYVIKGGC------GAGSGVKMVN 500
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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