|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
13-402 |
1.52e-149 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 429.33 E-value: 1.52e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 13 LVVLTTLFFMMGFITCMNDILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCLL 92
Cdd:cd17394 1 LALVTSLFFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 93 FYPAAGSHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLILADATQT--- 169
Cdd:cd17394 81 FIPAASLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIPSTata 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 170 ----------VSKAEQISSVQIPYLGLAGLLIILAVFVKMIRLPdANKIAEEESEHNHDGKHSVWQYRHLIFGAAGIFCY 239
Cdd:cd17394 161 laamsaaelqAYKTAELASVQLPYLGIALVLLLLAVLILLSKLP-EIEAAEAEALGSKGTLLRLLKNPHLRLGVLAIFFY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 240 VGAEVSIGSLLVNVLG-YLKGLDHASAAKYLSFYWGGAMVGRFLGSAIMAKIAPNRYLAFNATAAVVLLGVAMLAGKAsa 318
Cdd:cd17394 240 VGAEVAIWSFLINYLMeYIAGLTETSAATFVSYYWGGFMVGRFLGTALLKKISPKKLLAVFALLGLLLLLGAIFTGGM-- 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 319 dVAMWALLAIGFFNSIMFPTIFSLATKGLGRFTSSASGVLCTAIVGGAIVPVVQGWVADTQ-GLMISFVVSAICYVYIVF 397
Cdd:cd17394 318 -VALYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLIQGAVADDAaGLRIAFLVPLLCFAYILF 396
|
....*
gi 1080520331 398 FAIKG 402
Cdd:cd17394 397 YGLRG 401
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
5-405 |
1.16e-98 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 299.46 E-value: 1.16e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 5 SQQNHTPALVVLTTLFFMMGFITCMNDILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFV 84
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 85 LTAIGCLLFypaAGSHSYPTFLGALFILASGVTLLQVAGNPYVTLLSkPGKESATLTLVQAFNSLGTTIAPQIGAFLILA 164
Cdd:COG0738 82 LMALGLLLF---ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLILL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 165 DATqtvskaeqiSSVQIPYLGLAGLLIILAVFVKMIRLPDAnKIAEEESEHNHDGKHSVWQYRHLIFGAAGIFCYVGAEV 244
Cdd:COG0738 158 GLS---------LSWHLPYLILAVLLLLLALLFLRSKLPEI-EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 245 SIGSLLVNVLGYLKGLDHASAAKYLSFYWGGAMVGRFLGSAIMAKIAPNRYLAFNATAAVVLLGVAMLAGkaSADVAMWA 324
Cdd:COG0738 228 AIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP--GPWLALIG 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 325 LLAIGFFNSIMFPTIFSLATKGLGRFTSSA-SGVLCTAIVGGAIVPVVQGWVADTQGLMISFVVSAICYVYIVFFAIKGY 403
Cdd:COG0738 306 LALVGLGLSLMFPTIFSLALDGLGKRTAAAvSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALK 385
|
..
gi 1080520331 404 KA 405
Cdd:COG0738 386 RK 387
|
|
| gluP |
TIGR01272 |
glucose/galactose transporter; This model describes the glucose/galactose transporter in ... |
93-398 |
1.34e-81 |
|
glucose/galactose transporter; This model describes the glucose/galactose transporter in bacteria. This belongs to the larger facilitator superfamily. Disruption of the loci leads to the total loss of glucose or galactose uptake in E.coli. Putative transporters in other bacterial species were isolated by functional complementation, which restored it functional activity. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273531 [Multi-domain] Cd Length: 310 Bit Score: 252.89 E-value: 1.34e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 93 FYPAAGSHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLILADATQTVSK 172
Cdd:TIGR01272 1 FGPAASQRYYVLFLGALFVLASGLTILQVAANPYVSILGPIETAASRLALTQAFNKLGTTVAPLFGGSLILSGAGDLSMQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 173 AEQISS----VQIPYLGLAGLLIILAVFVKMIRLPDANKIAEEESEH-NHDGKHSVWQYRHLIFGAAGIFCYVGAEVSIG 247
Cdd:TIGR01272 81 VATANAeaakVHTPYLLLAGALAVLAIIFAFLPLPELQEADVARVSSgDTTQKTSAFQFTHLVLGALGIFVYVGAEVSAG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 248 SLLVNVLG--YLKGLDHASAAKYLSFYWGGAMVGRFLGSAIMAKIAPNRYLAFNATAAVVLLGVAMLAgkaSADVAMWAL 325
Cdd:TIGR01272 161 SFLVNFLSdpHALGLPEDQAAHFTAYTWGGAMVGRFIGSAVMPMISQGRYLAFNAFLAVLLSIGAALT---HGYVAMWFV 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1080520331 326 LAIGFFNSIMFPTIFSLATKGLGRFTSSASGVLCTAIVGGAIVPVVQGWVADTQGLMISFVVSAICYVYIVFF 398
Cdd:TIGR01272 238 LALGLFNSIMFPTIFSLALNALGRHTSQGSGILCLAIVGGAIVPLLQGSLADCLGIQLAFALPVPCYLYILFY 310
|
|
| PRK10133 |
PRK10133 |
L-fucose:H+ symporter permease; |
15-399 |
3.88e-58 |
|
L-fucose:H+ symporter permease;
Pssm-ID: 182260 [Multi-domain] Cd Length: 438 Bit Score: 195.88 E-value: 3.88e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 15 VLTTLFFMMGFITCMNDILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCLLFY 94
Cdd:PRK10133 30 LLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFW 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 95 PAAGSHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLILAD----ATQTV 170
Cdd:PRK10133 110 PAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLILSNvphqSQDVL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 171 SK--AEQIS--------SVQIPYLGLAGLLIILAVFVKMIRLPDAnkiaeeESEHNHDGKHSVW--------QYRHLIFG 232
Cdd:PRK10133 190 DKmtPEQLSaykhslvlSVQTPYMIIVAIVLLVALLIMLTKFPAL------QSDNHSDAKQGSFsaslsrlaRIRHWRWA 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 233 AAGIFCYVGAEVSIGSLLVN-VLGYLKGLDHASAAKYLSFYWGGAMVGRFLGSAIMAKIAPNRYLAFNATAAVVLLGVAM 311
Cdd:PRK10133 264 VLAQFCYVGAQTACWSYLIRyAVEEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCLISA 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 312 LAGkasADVAMWALLAIGFFNSIMFPTIFSLATKGLGRFTSSASGVLCTAIVGGAIVPVVQGWVADTQG-LMISFVVSAI 390
Cdd:PRK10133 344 FAG---GHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVMGFVSDAAGnIPTAELIPAL 420
|
....*....
gi 1080520331 391 CYVYIVFFA 399
Cdd:PRK10133 421 CFAVIFIFA 429
|
|
| fucP |
TIGR00885 |
L-fucose:H+ symporter permease; This family describes the L-fucose permease in bacteria. ... |
14-399 |
9.93e-53 |
|
L-fucose:H+ symporter permease; This family describes the L-fucose permease in bacteria. L-fucose(6-deoxy-L-galactose) is a monosaccharide found in glycoproteins and cell wall polysaccharides. L-fucose is used in bacteria through an inducible pathway mediated by atleast four enzymes: a permease, isomerase, kinase and an aldolase which are encoded by fucP, fucI, fucK, fucA respectively. The fuc genes belong to a regulon comprising of four linked operons: fucO, fucA, fucPIK and fucR. The positive regulator is encoded by fucR, whose protein responds to fuculose-1-phosphate, which acts as an effector. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 211614 Cd Length: 408 Bit Score: 181.20 E-value: 9.93e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 14 VVLTTLFFMMGFITCMNDILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCLLF 93
Cdd:TIGR00885 6 ALITSLFALWGFANDITNPMVPQFQQAFTLTAFQAALVQSAFYGGYFIMAIPAAIFMKKLSYKAGILLGLFLYALGAFLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 94 YPAAGSHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLILA-------DA 166
Cdd:TIGR00885 86 WPAAEIMNYTLFLVGLFILTAGLGFLETAANPYILVMGPESTATRRLNLAQSFNPFGSIIGMVVAQQLILSnlphqsqDV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 167 TQTVSKAEQIS-------SVQIPYLGLAGLLIILAVFVKMIRLPDANkiaeeeSEHNHDGKHS-----VWQYRHLIFGAA 234
Cdd:TIGR00885 166 LDKLSPEELSAikhsdlaSVQTPYMIIGAVVLAVALLIMLTKMPALN------HSDAKQISFSaslsrLARIRHYREGVI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 235 GIFCYVGAEVSIGSLLVNvlgYLKGLDHASAAKYLSFYWGGAMV----GRFLGSAIMAKIAPNRYLAFNATAAVVL-LGV 309
Cdd:TIGR00885 240 AQFFYVGVQIMCWTFIIQ---YAVRLIPGMTAGFAANYNIGAMViffiSRFIGTWLISYLAAHKVLMAYAIIGMALcLGS 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 310 AMLAGKasadVAMWALLAIGFFNSIMFPTIFSLATKGLGRFTSSASGVLCTAIVGGAIVPVVQGWVADTQGLM------I 383
Cdd:TIGR00885 317 IFAGGH----VGLYCLTLCSAFMSLMFPTIYGIALKGLGQDTKYGAAGLVMAIIGGGIVPPLQGFIIDMKEIAaapavnT 392
|
410
....*....|....*.
gi 1080520331 384 SFVVSAICYVYIVFFA 399
Cdd:TIGR00885 393 SFILPLLCFAVIFIYG 408
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
19-401 |
1.50e-38 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 142.46 E-value: 1.50e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 19 LFFMMGFITCMNDILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCLLFYPAag 98
Cdd:cd17333 4 SFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT-- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 99 sHSYPTFLGALFILASGVTLLQVAGNPYVTLLSkPGKESATLTLVQAFNSLGTTIAPQIGAFLIladatqtvskaEQISS 178
Cdd:cd17333 82 -PSIYLFVVLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGFFGLGALIGPLIATSLL-----------TSELS 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 179 VQIPYLGLAGLLIILAVFVKMIRLPDANKIAEEESEHNHDGKHSVWQYR--HLIFGAAGIFCYVGAEVSIGSLLVNVLGY 256
Cdd:cd17333 149 WSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRnpSIILGALALFLYVGAETAFSSWVPSYLVE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 257 LKGLDHASAAKYLSFYWGGAMVGRFLGSAIMAKIAPNRYLAFNATAAVVLLGVAMLAGKASadVAMWALLAIGFFNSIMF 336
Cdd:cd17333 229 KKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLV--VGLVATALLGLFMAALF 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1080520331 337 PTIFSLATKGLGRFTSSASGVLCTA-IVGGAIVPVVQGWVADTQGLMISFVVSAICYVYIVFFAIK 401
Cdd:cd17333 307 PTILSLGISNLPYAKGKGTSVLLAAgSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-400 |
7.50e-20 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 89.93 E-value: 7.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 12 ALVVLTTLFFMMGFITCMNDILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCL 91
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 92 LFypaAGSHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLILADatqtvs 171
Cdd:COG2271 91 LF---GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF------ 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 172 kaeqisSVQIPYLGLAGLLIILAVFVkmirlpdankiaeeesehnhdgkhsvwqyrhLIFGAAGIFCYVGAEVSIGSLLV 251
Cdd:COG2271 162 ------GWRAAFLILGLPGLLLALLR-------------------------------FWLLALAYFLVYFALYGFLTWLP 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 252 NVLGYLKGLDHASAAKYLSFYWGGAMVGRFLGSAIMAKIAPNRYLAFNATAAVVLLGVAMLAGKASADVAMWALLAIGFF 331
Cdd:COG2271 205 TYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFG 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1080520331 332 NSIMFPTIFSLATKGLG-RFTSSASGVLCT-AIVGGAIVPVVQGWVADTQGLMISFVVSAICYVYIVFFAI 400
Cdd:COG2271 285 LGGAFGLLWALAAELFPkKARGTASGLVNTfGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLAL 355
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-393 |
7.71e-17 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 81.47 E-value: 7.71e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 8 NHTPALVVLTTLFFMMGFITCMNDILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTA 87
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 88 IGCLLFYPAagsHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLILAdat 167
Cdd:COG2223 82 IGLLLLALA---VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAA--- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 168 qtvskaeqiSSVQIPYLGLAGLLIILAVFVkMIRLPDANKIAEEESEHNHDGKHSVWQYRHLIFGAAGIFCYVGAEVSIG 247
Cdd:COG2223 156 ---------FGWRNAFLILGILLLVVAVLA-WLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 248 SLLVNVLGYLKGLDHASAAKYLSFYWGGAMVGRFLGSAIMAKIAPNR-YLAFNATAAVVLLGVAMLAGkaSADVAMWALL 326
Cdd:COG2223 226 SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRvLLIVFALMALGLLLLALALG--SLWLFLVLFL 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 327 AIGFFNSIMFPTIFSLATKGLG-RFTSSASGVLCTA-IVGGAIVPVVQGWVADTQG-LMISFVVSAICYV 393
Cdd:COG2223 304 LLGLALGGGNGAVFALVPDIFPtKNAGAVYGLVGAAgGLGGFLGPLLFGALLDATGsYTAAFLVFAVLAL 373
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
15-368 |
3.36e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 79.00 E-value: 3.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 15 VLTTLFFMMGFITCMNDILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCLLfy 94
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 95 pAAGSHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLIladatqtvskae 174
Cdd:pfam07690 79 -LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA------------ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 175 QISSVQIPYLGLAGLLIILAVFVkMIRLPDANKIAEEESEHNHDGKHSVWQY--RHLIFGAAGIFCYVGAEVSIGSLLVN 252
Cdd:pfam07690 146 SLFGWRAAFLILAILSLLAAVLL-LLPRPPPESKRPKPAEEARLSLIVAWKAllRDPVLWLLLALLLFGFAFFGLLTYLP 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 253 VLGYLKGLDHASAAKYLSFYWGGAMVGRFLGSAIMAKIAPNRYLAFN-ATAAVVLLGVAMLAGKASADVAMWALLAIGFF 331
Cdd:pfam07690 225 LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAlLLLILAALGLLLLSLTLSSLWLLLALLLLGFG 304
|
330 340 350
....*....|....*....|....*....|....*...
gi 1080520331 332 NSIMFPTIFSLATKGLG-RFTSSASGVLCTAIVGGAIV 368
Cdd:pfam07690 305 FGLVFPALNALVSDLAPkEERGTASGLYNTAGSLGGAL 342
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-345 |
1.76e-15 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 76.94 E-value: 1.76e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 12 ALVVLTTLFFMMGFITCMNDILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCL 91
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 92 LfypAAGSHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLIladatqtvs 171
Cdd:COG2814 91 L---CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA--------- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 172 kaeQISSVQIPYLGLAGLLIILAVFVkMIRLPDANKiaeEESEHNHDGKHSVWQYRHLIFGAAGIFCYVGAEVSIGSLLV 251
Cdd:COG2814 159 ---DLFGWRWVFLVNAVLALLALLLL-LRLLPESRP---AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 252 NVLGYLKGLDHASAAKYLSFYWGGAMVGRFLGSAIMAKIAPNRYLAfnATAAVVLLGVAMLAGKASADVAMWALLAIGFF 331
Cdd:COG2814 232 LYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL--IGLLLLALGLLLLALAGSLWLLLLALFLLGFG 309
|
330
....*....|....
gi 1080520331 332 NSIMFPTIFSLATK 345
Cdd:COG2814 310 FGLLFPLLQALVAE 323
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
16-400 |
7.02e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 75.54 E-value: 7.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 16 LTTLFFMMGFITCMNDILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCLLFyp 95
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 96 aAGSHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLILADATqtvskaeq 175
Cdd:cd06174 79 -AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF-------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 176 isSVQIPYLGLAGLLIILAVFVKMIRLPDANKIAEEESEHNH----DGKHSVWQYRHLIFGAAGIFCYVGAEVSIGSLLV 251
Cdd:cd06174 150 --GWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSksvlKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 252 NVLGYLKGLDHASAAKYLSFYWGGAMVGRFLGSAIMAKIAPNRYLAFnATAAVVLLGVAMLAGKASADVAMWALLAIGFF 331
Cdd:cd06174 228 LFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL-IGLLLMALGLALLLLAPSLLLLLLLLLLLGFG 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1080520331 332 NSIMFPTIFSLATK--GLGRFTSSASGVLCTAIVGGAIVPVVQGWVAD-TQGLMISFVVSAICYVYIVFFAI 400
Cdd:cd06174 307 LGGLLPLSFALIAElfPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
21-390 |
2.18e-11 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 64.88 E-value: 2.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 21 FMMGFITcmndILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCLLFypaAGSH 100
Cdd:cd17478 10 FYQGFLP----ALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLL---GFAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 101 SYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESAtLTLVQAFNSLGTTIAPQIGAFLIladatqtvskaEQISSVQ 180
Cdd:cd17478 83 NYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRGLA-MSIFSVGGNLGFALGPLIAAALV-----------ALFGGLG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 181 IPYLGLAGLLIILAVFVKMIRLPDANKIAEEESEHNHDGKHSVWqyRHLIFGAAGIFCYVGAEVSIGSLLVnVLGYLKGL 260
Cdd:cd17478 151 LLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVW--RALLLLLIIVFLRSWVLSSLTTFLP-FYLVQRGY 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 261 DHASAAKYLSFYWGGAMVGRFLGSAIMAKIAPNRYLAFNATAAVVLLGVAMLAGkasaDVAMWALLAI-GFFNSIMFPTI 339
Cdd:cd17478 228 SLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTP----GIWSYILLVLaGFLLFASFPVT 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1080520331 340 FSLATKGLGRFTSSASG-VLCTAIVGGAIVPVVQGWVADTQGLMISFVVSAI 390
Cdd:cd17478 304 VVLAQELLPGNVGLASGlMMGLSFGLGGIGAPVLGALADAFGLESVLLILAL 355
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-400 |
1.65e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 62.21 E-value: 1.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 14 VVLTTLFFMMGFITCMNdiLIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCLLF 93
Cdd:cd17325 1 LSLALFLDMLGYGIIIP--ILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 94 ypaAGSHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLIladatqtvska 173
Cdd:cd17325 79 ---AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA----------- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 174 eQISSVQIPYLGLAGLLIILAVFVkMIRLPDANKIAEEESEHNHDGKHSVWQ--YRHLIFGAAGIFCYVGaeVSIGSLLV 251
Cdd:cd17325 145 -DALGYRAPFLVCAALALLALVLA-LLLLPEPRPPPNKRAVSAARLRSGLRLllRDRRLLALFLAIFVLA--FAFGALEP 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 252 NVLGYLKGLDHASAAKyLSFYWGGAMVGRFLGSAIMAKIA--PNRYLAFNATAAVVLLGVAMLAGKASADVAMWALLAIG 329
Cdd:cd17325 221 FLPLYAAELGGLSPAQ-IGLLFGAQGLASALSQPPAGKLSdrIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLG 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1080520331 330 FFNSIMFPTIFSLATKGLGRFT-SSASGVLCTAI-VGGAIVPVVQGWVADTQGLMISFVVSA-ICYVYIVFFAI 400
Cdd:cd17325 300 LGLGLVFPATLALLADIVPPEGrGTAMGLFNTAFsLGMVLGPLLGGFLYDAFGFATPFLAAAaLLLLAAVLFLL 373
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
16-399 |
2.16e-10 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 61.89 E-value: 2.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 16 LTTLFFMMGFITCMNDILIPHLKDIFELTYVQAMLIQFCFfTAYAIMSIPM-GYLVGKIGYKNGVIGGFVLTAIGCLLfy 94
Cdd:cd17393 4 VAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLAL-GVGALVAMPLaGRLVARFGSRRVTRLGALLLLLALLL-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 95 pAAGSHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESaTLTLVQAFNSLGTTIAPQIGAFLILADATQTVSkae 174
Cdd:cd17393 81 -LGLAPSVPALALALFLFGAANGALDVAMNAQGVAVERAYGRP-IMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVH--- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 175 qissvqipYLGLAGLLIILAVFVKMIRLPDANKIAEEESEHNHDGKHSVWQYRHLIFGAAGIFCYVGAEVSIGSLLVnvl 254
Cdd:cd17393 156 --------LLAAAVLLLLAALVAIRALLPGTGEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSAL--- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 255 gYLKGLDHASAAK----YLSFywGGAM-VGRFLGSAIMAKIAPNRYLAFNATAAVVLLGVAMLAGKASADVAMWALLAIG 329
Cdd:cd17393 225 -YLRDVLGASAALaalgYAVF--SLAMtVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLG 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1080520331 330 FfnSIMFPTIFSLATKGLGRFTSSASGVLCTAIVGGAIV-PVVQGWVADTQGLMISFVVSAICYVYIVFFA 399
Cdd:cd17393 302 L--SVVVPLAFSAAGALPGLAAGIAVARVATLGYLGFLVgPPLIGFLADATGLRTAFLVVALLALLVALLA 370
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
20-398 |
4.90e-09 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 57.63 E-value: 4.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 20 FFMMGFITCMNdILIPHLKDIFELTyVQAMLIQFCFFTAYAIMSIPM-GYLVGKIGYKNGVIGGFVLTAIGCL-LFYpaa 97
Cdd:PRK03699 17 ALTGALVIVTG-MVMGPIAEYFNLP-VSSMSNTFTFLNAGILISIFLnAWLMEIIPLKRQLIFGFALMILAVAgLMF--- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 98 gSHSYPTFLGALFILA--SGVTLlqVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLILADATQTVSkaeq 175
Cdd:PRK03699 92 -SHSLALFSIAMFVLGvvSGITM--SIGTFLITHVYEGKQRGSRLLFTDSFFSMAGMIFPIIAAYLLARSIEWYWV---- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 176 issvqipYLGLAGLLIILAVFVKMIRLPdanKIAEEESEHNHDGKHSVWQYRhLIFGAAGIFCYVGAEVSIGSLLVNVLG 255
Cdd:PRK03699 165 -------YACIGLVYVAIFILTLFSEFP---ALGKHAPKADKPVAKEKWGIG-VLFLAIAALLYILAQLTFISWVPEYAQ 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 256 YLKGLDHASAAKYLSFYWGGAMVGRFLGSAIMAKIAPNRYLAFNATAAVVLLgvAMLAGKASADVAMWALLAIGFFNSIM 335
Cdd:PRK03699 234 KKFGMSLEDAGNLVSNFWMAYMVGMWIFSFIVRFFDLQRILTVLAGLALVLM--YLFVNTDDPSHLLYAILGLGFFSSAI 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1080520331 336 FPTIFSLATKglgrFTSSASGVLCTAI-----VGGAIVPVVQGWVADTQGLMISFVVSAICYVyIVFF 398
Cdd:PRK03699 312 YTTIITLGSQ----QTKVASPKLVNFIltcgtIGTMLTFVVTSPIVAHFGLQAALLTANGLYA-VVFV 374
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
33-400 |
6.01e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 54.11 E-value: 6.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 33 LIPHLKDIFELTYVQA----MLIQFCFftayAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCLLFYPAagsHSYPTFLGA 108
Cdd:COG2807 40 LLPEIRADLGLSATQAglltTLPLLAF----GLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLA---PSVALLLAG 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 109 LFILASGVTLLQVAGNPYVTLLSkPGKESATLTLVQAFNSLGTTIAPQIGAFLILAdatqtvskaeqiSSVQIPYLGLAG 188
Cdd:COG2807 113 TALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAA------------LGWRGALAVWAL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 189 LLIILAVFVkmIRLPDANKIAEEESEHNHDGKHsVWQYRHLIFGAAGIFCYVGAEVSIGSLLVNVLGYLkGLDHASAAKY 268
Cdd:COG2807 180 LALLALLLW--LPLLRRRPAAAAAAPAAASLRS-LWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 269 LSFYWGGAMVGRFLGSAIMAKIAPNRYLAFnATAAVVLLGVAMLAGkASADVAMWALLAIGFFNSIMFPTIFSLA---TK 345
Cdd:COG2807 256 LSLFQLAGIPGSLLVPLLADRLGDRRPLLL-LLGLLGLAGLLGLLL-APGSLPWLWAVLLGLGQGGLFPLALTLIglrAR 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1080520331 346 GLGRFTSSASGVLCTAIVGGAIVPVVQGWVAD-TQGLMISFVVSAICYVYIVFFAI 400
Cdd:COG2807 334 TPAEAAALSGMAQSVGYLLAALGPLLVGALHDaTGSWTAALLLLAALAVLMLVAGL 389
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
32-393 |
1.01e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 50.26 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 32 ILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCLLFypaAGSHSYPTFLGALFI 111
Cdd:cd17319 24 VAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALT---GFATSLTSLYVLRFL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 112 LASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLILADATQTVSKAEQISSVqipylglaglli 191
Cdd:cd17319 101 LGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGL------------ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 192 ilaVFVKMIRlpdankiaeeesehnhdgkhsvWQYRHLIFGAAGIFCYVGAEVSIGSLLVNVLGYLKGLDHASAAKYLSF 271
Cdd:cd17319 169 ---LLAVLWW----------------------FYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAI 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 272 YWGGAMVGRFLGSAIMAKIAPNRYLAFNATAAVVLLGVAMLAGKA-SADVAMWALLAIGFFNSIMFPTIFSLATKGLGRF 350
Cdd:cd17319 224 PFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTtSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGE 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1080520331 351 TSSASGVLCTAI--VGGAIVPVVQGWVAD-TQGLMISFVVSAICYV 393
Cdd:cd17319 304 AAATAGGLINSGgnLGGFVAPLLIGYLVDaTGSYTAAFLFLAAVAL 349
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-162 |
3.84e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 48.73 E-value: 3.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 13 LVVLTTLFFMMGFITCMNDILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCLL 92
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 93 FypaAGSHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLI 162
Cdd:cd17325 282 L---PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLY 348
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
21-165 |
4.40e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 48.34 E-value: 4.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 21 FMMGFITCMNDILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCLLfypAAGSH 100
Cdd:cd17474 9 LLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL---CGLSD 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1080520331 101 SYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLILAD 165
Cdd:cd17474 86 SFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIS 150
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
14-400 |
5.50e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.97 E-value: 5.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 14 VVLTTLFFMMGFitcmnDILIPHL----KDIFElTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIG 89
Cdd:cd17489 1 ILLANFFFFLSF-----YLLLPVLplyaHDLGG-SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 90 CLLFYPAagsHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLiladatqt 169
Cdd:cd17489 75 TLLYLLA---TSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFL-------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 170 vskaeqISSVQIPYLGLAGLLIILAVFVKMIRLPDANKIAEEESEHNHDGKHSVWQYRHLIFGAAGIFCYVGaevsIGSL 249
Cdd:cd17489 144 ------YQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIA----YGAI 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 250 LVNVLGYLKGLDHASAAKYLSFYWGGAMVGRFLGSAIMAKIAPNRYLAFnaTAAVVLLGVAMLAGKASADVAMWALLAIG 329
Cdd:cd17489 214 STFLPLYAAERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIP--GLLLLALGLLLLSFAGSPWMLLLAAVLYG 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1080520331 330 FFNSIMFPTIFSLATKGLGRFT-SSASGVLCTAI-VGGAIVPVVQGWVADTQGLMISFVVSAICYVYIVFFAI 400
Cdd:cd17489 292 LGFGLLFPALQALAVDLVPPHRrGAANGTFFIFFdLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
10-155 |
1.04e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.03 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 10 TPALVVLTTLFFMMGFITCMNDILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIG 89
Cdd:pfam07690 199 RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1080520331 90 CLLFYPAAGSHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAP 155
Cdd:pfam07690 279 ALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
11-179 |
1.58e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.82 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 11 PALVVLTTLFFMMGFITCMNDILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGC 90
Cdd:COG2211 229 PFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 91 LLFYpAAGSHSYPTFLGALFILASGVTLLQVAGN-------PYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLIl 163
Cdd:COG2211 309 LLLF-FLGPGNLWLLLVLAALAGIGLGAILVLPWamladvvDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLL- 386
|
170
....*....|....*.
gi 1080520331 164 aDATQTVSKAEQISSV 179
Cdd:COG2211 387 -ALFGYVAGAAQSPSA 401
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
12-390 |
1.86e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.39 E-value: 1.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 12 ALVVLTTLFFMMGfitcmndiLIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCL 91
Cdd:cd17324 8 AFAIGTTEYVIQG--------LLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 92 LfypAAGSHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLiladatqtvs 171
Cdd:cd17324 80 L---AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL---------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 172 kaEQISSVQIPYLGLAGLLIILAVFVkMIRLPDANKIAEEESEHNHDGKHsVWQYRHLIFGAAGIFCYVGAEVSIGSLLV 251
Cdd:cd17324 147 --GQLLGWRAAFLAIAVLALLAALLL-WRLLPSLPPKKPGSLGLLSSLLL-LLRNPRLRLAYLITFLLFGGFFALYTYLA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 252 NVLGYLKGLDHASAAKYLSFYWGGAMVGRFLGSAIMAKIAPNRYLAFNATAAVVLLGVAMLAGKASADVAMWALLAIGFF 331
Cdd:cd17324 223 PFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 332 nsIMFPTIFSLATKGLGRFTSSASGVLCTAI-VGGAIVPVVQGWVADTQGLMISFVVSAI 390
Cdd:cd17324 303 --AAHSALQTRVLRLAPEARGLASSLYLAAYnLGGALGAALGGLVLDHGGWAGVGWVGAA 360
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
33-400 |
2.08e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 46.14 E-value: 2.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 33 LIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCLLfypAAGSHSYPTFLGALFIL 112
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL---CGFAQNYWQLLILRALA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 113 ASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLIladatqtvskaeQISSVQIPYLGLAGLLII 192
Cdd:cd17371 98 GLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLF------------PLLPPEIAWRVLFLLGAL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 193 LAVFVKMIR--LPDANKIAEEESEHNHDGKHSVW------QYRHLIFGAAGIFCYV-GAEVSIGSLLVNVLGYLKGLDHA 263
Cdd:cd17371 166 PALLVLFIRrfVKEPPQWQAARAARRHFADRPSLrelfspPLLRTTLLASLLATGAlGGYYGITTWLPSYLTGERGLSFE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 264 SAAKYLSFYWGGAMVGRFLGSAIMAKIAPNRYLAFNATAAVVLLgVAMLAGKASADVAMWALLAIGFFNSIMF------- 336
Cdd:cd17371 246 GSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISI-LLYFFLPLSPTLILILGFPLGFFASGPFsgmgayl 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1080520331 337 PTIFSLATKGLGRFTSSASGVLctaivGGAIVPVVQGWVADTQGLMISFVVSAICYVYIVFFAI 400
Cdd:cd17371 325 TELFPTAVRATAQGFCYNVGRI-----IGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLA 383
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
11-162 |
6.46e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 44.88 E-value: 6.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 11 PALVVLTTLFFMMGFITCMNDILIPHLKDI-----FELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVL 85
Cdd:cd17504 177 RNVLLANITALLAGFGMFMVFQLLPQLLQLptptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVI 256
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1080520331 86 TAIGCLLfypAAGSHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLT-LVQAFNSLGTTIAPQIGAFLI 162
Cdd:cd17504 257 SAVGLLL---LALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATgMNTVLRTIGSAIGPAIAGAIL 331
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
12-154 |
1.14e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.09 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 12 ALVVLTTLFFMMGFITcMNDILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCL 91
Cdd:cd17321 171 SGAVLAAFLLGAALGG-LLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLL 249
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1080520331 92 LFYPAAGSHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIA 154
Cdd:cd17321 250 LLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALG 312
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
54-393 |
3.31e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.55 E-value: 3.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 54 CFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCLLFYPaagSHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKP 133
Cdd:cd17477 39 AYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL---TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATN 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 134 GKESATLTLVQAFNSLGTTIAPQIGAFLILADATqtvskaeqissvqiPYLGLAGLLIILAVFVKMIRLPDANKIAEEES 213
Cdd:cd17477 116 ENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL--------------PFLIAAVLLLLALVPLLLTRRAAPEIEEAESI 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 214 ehnhdgkhSVWQ-YRHLIFGAAGIFCYVGAEVSIGSLLVnVLGYLKGLDHASAAKYLSFYWGGAMVGRFLGSAIMAKIAP 292
Cdd:cd17477 182 --------SLRRlLRIAPLALLGAFVAGFLEGAFYSLLP-LYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDR 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 293 NRYLAFNATAAVVLLGVAMLAGKASadvamWALLAIGFFNSIMFPTIFSLATKGLG-RFTSSASGVLCTAI-----VGGA 366
Cdd:cd17477 253 RRVLLGCALLGALAALLLPLVPGLP-----LALLVLLFLWGGAAGPLYTLALALAGdRLPGDELVAANAALlllygLGSV 327
|
330 340 350
....*....|....*....|....*....|
gi 1080520331 367 IVPVVQGWVAD---TQGLMISFVVSAICYV 393
Cdd:cd17477 328 IGPLLAGALMDafgPHGLFLFLAAVALLFL 357
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
50-401 |
4.21e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.22 E-value: 4.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 50 LIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCLLFY--PAAGSHSYPTFLGALFILASGVTLLQVAGNPYV 127
Cdd:cd06173 38 LVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLAllALLGSLSLWLLLVLAFLLGIASAFFGPARQALL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 128 TLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLILADATQTVskaeqissvqipYLGLAGLLIILAVFVKMIRLPDANK 207
Cdd:cd06173 118 PELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA------------FAINALSFLLSALLLLFIRRPPPAA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 208 IAEEESEHNHDGKHSVWQYRHLIFGAAGIFCYVGAEVSIGSLLVNVLGYLKGLDHASAAKY---LSFYWGGAMVGrflgS 284
Cdd:cd06173 186 PGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYgllLAAFGVGALLG----A 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 285 AIMAKIAPNRYLAFNATAAVVLLGVAMLAGKASADVAMW--ALLAIGFFNSIMFPTIFSL-----ATKGLGRFTSSASGV 357
Cdd:cd06173 262 LLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLlaALFLLGLAGGLFNVPLNTLlqlrvPDELRGRVFSVYNAL 341
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1080520331 358 LCTAIVGGAivpVVQGWVADTQGLMISFVVSAICYVYIVFFAIK 401
Cdd:cd06173 342 NSGAMPLGA---LLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_MFSD4 |
cd17395 |
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily ... |
229-398 |
6.63e-04 |
|
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily domain-containing protein 4 (MFSD4) subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The MFSD4 subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340953 [Multi-domain] Cd Length: 367 Bit Score: 41.36 E-value: 6.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 229 LIFGAAGIFCYVGAEVSIGSLLVNVLGYLKGLDHASAAKYLSFYWGGAMVGRFLGSAIMAKIAPNRYLAFNATAAVVLLG 308
Cdd:cd17395 194 HITGALFLFMYVGLEGAYGAFVYSYAVEKPGVGHKVAAYLPSLFWGTFTLGRLLSIPISSRMKPATMVVLNVVGVVVTSL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 309 VAMLAGKaSADVAMWALLAIGFFNSIMFPTIFSLaTKGLGRFTSSASGVLCT-AIVGGAIVPVVQGWVADTQG-LMISFV 386
Cdd:cd17395 274 VLLLFSK-SVVFLWIGTASLGLFLASTFPSMLSY-TEDSLQYTGCSTTVLVTgAGLGEMVLPMLVGSIQPFQAqGSYSFL 351
|
170
....*....|..
gi 1080520331 387 VSAICYVYIVFF 398
Cdd:cd17395 352 VCGVLFGCLAFT 363
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-162 |
7.60e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.95 E-value: 7.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 1 MSAHSQQNHTPALVVLTTLFFMMGFITCMNDILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVI 80
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 81 GGFVLTAIGCLLfypAAGSHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAF 160
Cdd:COG0477 84 IGLLLFGLASLL---CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGL 160
|
..
gi 1080520331 161 LI 162
Cdd:COG0477 161 LV 162
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
13-391 |
7.79e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.44 E-value: 7.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 13 LVVLTTLFFMMGFITCmndilipHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCLL 92
Cdd:cd17329 9 FLNRLGFFMVWPFMAI-------YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 93 FYPAagsHSYPTFLGALFILASGVTLLQVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLILADATQTVsk 172
Cdd:cd17329 82 LGFA---HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLF-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 173 aeqissvqipylGLAGLLIILAVFVKMIRLP-DANKIAEEESEHNHDGKHSVWQYR----HLIFGAAGIFCYVGAEVSIG 247
Cdd:cd17329 157 ------------LAAAVLFLLAALVLLFLLPeTRPKRRAAEKTEILRGYKIVLRDRafllFLLASFLISLIYFQLESTLP 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 248 SLLVNVLGYlkgldhasAAKYLSFYWGGAMVGRFLGSAIMAKIAPNRYLAFNATAAVVLLGVAMLAGKASADVAMWALLA 327
Cdd:cd17329 225 VYVVEILGL--------GESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAM 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1080520331 328 IGFF--NSIMFPTIFSLATK-----GLGRFTSSASGVLctaIVGGAIVPVVQGWVADTQGLMISFVVSAIC 391
Cdd:cd17329 297 IVLTlgEMLVFPAVQTLVAAlappdKRGSYMGFYALAW---GLGRAIGPLVGGLLLDLLGPGLPWLILAAL 364
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
222-400 |
1.22e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.66 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 222 SVWQYRHLIFGAAGIFCYVGAEVSIGSLLVNVLGYLKGLDHASAAKYLSFYWGGAMVGRFLGSAIMAKIAPNRYLAFNAT 301
Cdd:cd17316 172 ALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLI 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 302 AAVVLLGVAMLAGKASADVAMWALLAIGFFNS-------IMFPTIFSLATKGLGRFTSSASGvlctAIVGGAIVPVVQGW 374
Cdd:cd17316 252 LSGILALPLFYLLSGSPTLLLLLLFILSFFVGgvwgalyAYLAELFPTEVRATGVGLSYNLG----RLGGGGAPPLIALL 327
|
170 180
....*....|....*....|....*.
gi 1080520331 375 VADTQGLMISFVVSAICYVYIVFFAI 400
Cdd:cd17316 328 LASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
14-391 |
2.43e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.93 E-value: 2.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 14 VVLTTLFFMMGFITCMN-DILIPHLKDIFELTYVQAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCLL 92
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLfAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 93 FypAAGSHSYPTFLGALFILASGVTLLqVAGNPYVTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFLILADATQTVSK 172
Cdd:cd17341 81 L--ALAVSSYWGLLVLGFLLGFAGANF-ASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFDGGFV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 173 AEQISSVqipYLGLAGLLIILAVFVKMIRLPDANKIAEEESehnHDGKHSVWQYRHLIFGAAGIFCYvGAEVSIGSLLVN 252
Cdd:cd17341 158 GWRNAFF---VPGILLAIAAVLVLLFGDDLPTGKASALEFL---KVQLAVLKNYRTWILSLLYGVTF-GSFVGFSNVLPT 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 253 VLGYLKGLDHASAAKYLSFYWGGAMVGRFLGSAIMAKIAPNRYLAFN---ATAAVVLLGVAMLAGKASADVAMWALLAIG 329
Cdd:cd17341 231 YFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLfivMTIGAALLSLSLPTSGTNLVLFLALFVALG 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1080520331 330 FFNSIMFPTIFSLATKGLGRFTSSASG-VLCTAIVGGAIVPVVQGWVAD-----TQGLMISFVVSAIC 391
Cdd:cd17341 311 LGAGAGNGSVFRMVPFIFRRELGAVTGlVGAIGGLGGFFLPLLFGSSALmtgsgVGAFSLFGVLAVAC 378
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
47-161 |
4.79e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 38.72 E-value: 4.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080520331 47 QAMLIQFCFFTAYAIMSIPMGYLVGKIGYKNGVIGGFVLTAIGCLLfypAAGSHSYPTFLGALFILASGVTLLQVAGNPY 126
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVL---SAFSPSYELFLVLRFLVGVTSAGIFTVGFVL 102
|
90 100 110
....*....|....*....|....*....|....*
gi 1080520331 127 VTLLSKPGKESATLTLVQAFNSLGTTIAPQIGAFL 161
Cdd:cd17317 103 GMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLI 137
|
|
| |
