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Conserved domains on  [gi|1081036690|gb|OFR91402|]
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transcriptional regulator [Staphylococcus sp. HMSC059F04]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442335)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.357.10
Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
7-106 3.93e-12

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 61.07  E-value: 3.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081036690   7 RVVKTRASINKAFITLFFEKDFDTISIKEITEYAQVGRKTFYLHYIDKYDLLDQVVSEKLTELEKICEAKKLLG-----L 81
Cdd:COG1309     3 RREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEdprerL 82

                          90       100
                  ....*....|....*....|....*
gi 1081036690  82 QEGTQLWFEFFENNRSFFMKLFNIS 106
Cdd:COG1309    83 RALLRAYLEFLAENPALARLLLAEA 107
TetR_C_8 pfam14278
Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, ...
 81-154 5.33e-05

Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, or C-terminus.


:

Pssm-ID: 464123  Cd Length: 103  Bit Score: 40.68  E-value: 5.33e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1081036690  81 LQEGTQLWFEFFENNRSFFMKLFNISNASSYKKKLLHFIEEEFKKKVPTTVATD--KGLDYHLYINFISNGMIGLL 154
Cdd:pfam14278   3 WQEGLLKIFEYIKENKDFYRNLLSSNGRESFERYLYELTKELILGVVEELSEGMnvSEEDKDFIADFYSYGFVGLI 78
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
7-106 3.93e-12

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 61.07  E-value: 3.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081036690   7 RVVKTRASINKAFITLFFEKDFDTISIKEITEYAQVGRKTFYLHYIDKYDLLDQVVSEKLTELEKICEAKKLLG-----L 81
Cdd:COG1309     3 RREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEdprerL 82

                          90       100
                  ....*....|....*....|....*
gi 1081036690  82 QEGTQLWFEFFENNRSFFMKLFNIS 106
Cdd:COG1309    83 RALLRAYLEFLAENPALARLLLAEA 107
DHAK_reg TIGR02366
probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from ...
 11-105 2.45e-10

probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from a set of closely related uncharacterized proteins associated with operons for the type of bacterial dihydroxyacetone kinase that transfers PEP-derived phosphate from a phosphoprotein, as in phosphotransferase system transport, rather than from ATP. Members have a TetR transcriptional regulator domain (pfam00440) at the N-terminus and sequence homology throughout.


Pssm-ID: 274100 [Multi-domain]  Cd Length: 176  Bit Score: 56.70  E-value: 2.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081036690  11 TRASINKAFITLFFEKDFDTISIKEITEYAQVGRKTFYLHYIDKYDLLDQVVSEKLTELekICEAKKLLGLQEGTQLWFE 90
Cdd:TIGR02366   4 TKKKIAKAFKDLMEVQAFHKISVSDIMQTAQIRRQTFYNHFQDKYELLSWIFETELKEQ--VIDNLDYISWQNILDLLLR 81

                          90
                  ....*....|....*
gi 1081036690  91 FFENNRSFFMKLFNI 105
Cdd:TIGR02366  82 YFDENQTFYQKAFVI 96
TetR_C_8 pfam14278
Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, ...
 81-154 5.33e-05

Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, or C-terminus.


Pssm-ID: 464123  Cd Length: 103  Bit Score: 40.68  E-value: 5.33e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1081036690  81 LQEGTQLWFEFFENNRSFFMKLFNISNASSYKKKLLHFIEEEFKKKVPTTVATD--KGLDYHLYINFISNGMIGLL 154
Cdd:pfam14278   3 WQEGLLKIFEYIKENKDFYRNLLSSNGRESFERYLYELTKELILGVVEELSEGMnvSEEDKDFIADFYSYGFVGLI 78
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
7-83 2.09e-04

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 40.27  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081036690   7 RVVKTRASINKAFITLFFEKDFDTISIKEITEYAQVGRKTFYLHYIDKYDLLDQVVSEKLTELEKI---CEAKKLLGLQE 83
Cdd:NF041196    3 RAIRTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLREAvepQRAGGGSKLQE 82
CBD_TIP60_like cd18985
chromo barrel domain of human tat-interactive protein 60, and similar proteins; ...
 29-77 4.91e-04

chromo barrel domain of human tat-interactive protein 60, and similar proteins; Tat-interactive protein 60 (also known as KAT5 or HTATIP) catalyzes the acetylation of lysine side chains in various histone and nonhistone proteins, and in itself. It plays roles in multiple cellular processes including remodeling, transcription, DNA double-strand break repair, apoptosis, embryonic stem cell identity, and embryonic development. The TIP60 chromo barrel domain recognizes trimethylated lysine at site 9 of histone H3 (H3K9me3) which triggers TIP60 to acetylate and activate ataxia telangiectasia-mutated kinase, thereby promoting the DSB repair pathway. In a different study, the TIP60 chromo barrel domain was shown to bind H3K4me1, which stabilizes TIP60 recruitment to a subset of estrogen receptor alpha target genes, facilitating regulation of the associated gene transcription. SH3-fold-beta-barrel domains of the chromo-like superfamily include chromodomains, chromo shadow domains, and chromo barrel domains, and are implicated in the recognition of lysine-methylated histone tails and nucleic acids. The chromodomain differs, in that it lacks the first strand of the SH3-fold-beta-barrel. This first strand is altered by insertion in the chromo shadow domains, and chromo barrel domains are typical SH3-fold-beta-barrel domains with sequence similarity to the canonical chromodomain. This subgroup belongs to the MOF-like chromo barrels may be may be auto-inhibited, i.e. they seem to have occluded peptide binding sites.


Pssm-ID: 350848 [Multi-domain]  Cd Length: 64  Bit Score: 37.18  E-value: 4.91e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1081036690  29 DTISIKEITeyaqvGRKTFYLHYIDKYDLLDQVVSEKLTELEKICEAKK 77
Cdd:cd18985    17 EILSVKDIS-----GRKLFYVHYIDFNKRLDEWVTHERLDLKKIQFPKK 60
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
7-106 3.93e-12

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 61.07  E-value: 3.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081036690   7 RVVKTRASINKAFITLFFEKDFDTISIKEITEYAQVGRKTFYLHYIDKYDLLDQVVSEKLTELEKICEAKKLLG-----L 81
Cdd:COG1309     3 RREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEdprerL 82

                          90       100
                  ....*....|....*....|....*
gi 1081036690  82 QEGTQLWFEFFENNRSFFMKLFNIS 106
Cdd:COG1309    83 RALLRAYLEFLAENPALARLLLAEA 107
DHAK_reg TIGR02366
probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from ...
 11-105 2.45e-10

probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from a set of closely related uncharacterized proteins associated with operons for the type of bacterial dihydroxyacetone kinase that transfers PEP-derived phosphate from a phosphoprotein, as in phosphotransferase system transport, rather than from ATP. Members have a TetR transcriptional regulator domain (pfam00440) at the N-terminus and sequence homology throughout.


Pssm-ID: 274100 [Multi-domain]  Cd Length: 176  Bit Score: 56.70  E-value: 2.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081036690  11 TRASINKAFITLFFEKDFDTISIKEITEYAQVGRKTFYLHYIDKYDLLDQVVSEKLTELekICEAKKLLGLQEGTQLWFE 90
Cdd:TIGR02366   4 TKKKIAKAFKDLMEVQAFHKISVSDIMQTAQIRRQTFYNHFQDKYELLSWIFETELKEQ--VIDNLDYISWQNILDLLLR 81

                          90
                  ....*....|....*
gi 1081036690  91 FFENNRSFFMKLFNI 105
Cdd:TIGR02366  82 YFDENQTFYQKAFVI 96
TetR_C_8 pfam14278
Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, ...
 81-154 5.33e-05

Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, or C-terminus.


Pssm-ID: 464123  Cd Length: 103  Bit Score: 40.68  E-value: 5.33e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1081036690  81 LQEGTQLWFEFFENNRSFFMKLFNISNASSYKKKLLHFIEEEFKKKVPTTVATD--KGLDYHLYINFISNGMIGLL 154
Cdd:pfam14278   3 WQEGLLKIFEYIKENKDFYRNLLSSNGRESFERYLYELTKELILGVVEELSEGMnvSEEDKDFIADFYSYGFVGLI 78
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
7-83 2.09e-04

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 40.27  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081036690   7 RVVKTRASINKAFITLFFEKDFDTISIKEITEYAQVGRKTFYLHYIDKYDLLDQVVSEKLTELEKI---CEAKKLLGLQE 83
Cdd:NF041196    3 RAIRTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLREAvepQRAGGGSKLQE 82
CBD_TIP60_like cd18985
chromo barrel domain of human tat-interactive protein 60, and similar proteins; ...
 29-77 4.91e-04

chromo barrel domain of human tat-interactive protein 60, and similar proteins; Tat-interactive protein 60 (also known as KAT5 or HTATIP) catalyzes the acetylation of lysine side chains in various histone and nonhistone proteins, and in itself. It plays roles in multiple cellular processes including remodeling, transcription, DNA double-strand break repair, apoptosis, embryonic stem cell identity, and embryonic development. The TIP60 chromo barrel domain recognizes trimethylated lysine at site 9 of histone H3 (H3K9me3) which triggers TIP60 to acetylate and activate ataxia telangiectasia-mutated kinase, thereby promoting the DSB repair pathway. In a different study, the TIP60 chromo barrel domain was shown to bind H3K4me1, which stabilizes TIP60 recruitment to a subset of estrogen receptor alpha target genes, facilitating regulation of the associated gene transcription. SH3-fold-beta-barrel domains of the chromo-like superfamily include chromodomains, chromo shadow domains, and chromo barrel domains, and are implicated in the recognition of lysine-methylated histone tails and nucleic acids. The chromodomain differs, in that it lacks the first strand of the SH3-fold-beta-barrel. This first strand is altered by insertion in the chromo shadow domains, and chromo barrel domains are typical SH3-fold-beta-barrel domains with sequence similarity to the canonical chromodomain. This subgroup belongs to the MOF-like chromo barrels may be may be auto-inhibited, i.e. they seem to have occluded peptide binding sites.


Pssm-ID: 350848 [Multi-domain]  Cd Length: 64  Bit Score: 37.18  E-value: 4.91e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1081036690  29 DTISIKEITeyaqvGRKTFYLHYIDKYDLLDQVVSEKLTELEKICEAKK 77
Cdd:cd18985    17 EILSVKDIS-----GRKLFYVHYIDFNKRLDEWVTHERLDLKKIQFPKK 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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