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Conserved domains on  [gi|1081125438|gb|OFS74152|]
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hypothetical protein HMPREF3167_05870 [Trueperella sp. HMSC08B05]

Protein Classification

type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein( domain architecture ID 15994591)

type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein is part of the innate immunity bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection; may also contain a C-terminal domain similar to DUF559

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MTES_1575 super family cl46272
REase_MTES_1575; Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase ...
 219-324 4.59e-10

REase_MTES_1575; Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase and wHTH.


The actual alignment was detected with superfamily member COG2852:

Pssm-ID: 480612  Cd Length: 104  Bit Score: 56.03  E-value: 4.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081125438 219 LRRAspfsESGLETRVRLFLLSNR---VHVQPQVYIPSvGRVDMV-AGSSLILECNGDlAHSTKEQRNRDYIRIQNARLL 294
Cdd:COG2852     1 LRRN----DTPAERRLWQRLRNRQlrgLKFRRQVPIGG-YIVDFYcPEARLAIEVDGG-YHGSPEQRERDRRRDAYLERL 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 1081125438 295 GYETVSLSYAQIFWQWEETQAYLLALIRQR 324
Cdd:COG2852    75 GWRVLRFWNEDVLRNPEGVLEEILAALEER 104
AbiEi_4 pfam13338
Transcriptional regulator, AbiEi antitoxin; AbiEi_4 is the cognate antitoxin of the type IV ...
 62-105 7.44e-07

Transcriptional regulator, AbiEi antitoxin; AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.


:

Pssm-ID: 463849  Cd Length: 49  Bit Score: 45.23  E-value: 7.44e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1081125438  62 ARKKFGLVTQADLKTMGYtSHYAISKAVKAGRFQRLRHGVYALP 105
Cdd:pfam13338   7 AARQKGIFTTADLAAAGI-SRRALRRLVRKGLLERLRRGVYALP 49
AbiEi super family cl44219
Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system ...
 63-158 1.54e-05

Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system [Defense mechanisms];


The actual alignment was detected with superfamily member COG5340:

Pssm-ID: 444124 [Multi-domain]  Cd Length: 203  Bit Score: 44.99  E-value: 1.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081125438  63 RKKFGLVTQADLKTMGY---TSHYAISKAVKAGRFQRLRHGVYALPRADPDA-----IRAVKLG--GAIACESACRRYGI 132
Cdd:COG5340     3 TQGRGVFTTADARAAGLsagISRRLLSRLVKKGELERVRRGLYVLPPAEADKehdelLIAARLVppGYISLLSALALHGL 82

                          90       100
                  ....*....|....*....|....*...
gi 1081125438 133 --WVPHQgLHMAVQRNQTTSRPQGVTIH 158
Cdd:COG5340    83 tdQIPFT-VYVAVPRRSRPIKIGGPPIR 109
 
Name Accession Description Interval E-value
YcjD COG2852
Very-short-patch-repair endonuclease [Replication, recombination and repair];
219-324 4.59e-10

Very-short-patch-repair endonuclease [Replication, recombination and repair];


Pssm-ID: 442100  Cd Length: 104  Bit Score: 56.03  E-value: 4.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081125438 219 LRRAspfsESGLETRVRLFLLSNR---VHVQPQVYIPSvGRVDMV-AGSSLILECNGDlAHSTKEQRNRDYIRIQNARLL 294
Cdd:COG2852     1 LRRN----DTPAERRLWQRLRNRQlrgLKFRRQVPIGG-YIVDFYcPEARLAIEVDGG-YHGSPEQRERDRRRDAYLERL 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 1081125438 295 GYETVSLSYAQIFWQWEETQAYLLALIRQR 324
Cdd:COG2852    75 GWRVLRFWNEDVLRNPEGVLEEILAALEER 104
AbiEi_4 pfam13338
Transcriptional regulator, AbiEi antitoxin; AbiEi_4 is the cognate antitoxin of the type IV ...
 62-105 7.44e-07

Transcriptional regulator, AbiEi antitoxin; AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.


Pssm-ID: 463849  Cd Length: 49  Bit Score: 45.23  E-value: 7.44e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1081125438  62 ARKKFGLVTQADLKTMGYtSHYAISKAVKAGRFQRLRHGVYALP 105
Cdd:pfam13338   7 AARQKGIFTTADLAAAGI-SRRALRRLVRKGLLERLRRGVYALP 49
AbiEi COG5340
Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system ...
 63-158 1.54e-05

Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system [Defense mechanisms];


Pssm-ID: 444124 [Multi-domain]  Cd Length: 203  Bit Score: 44.99  E-value: 1.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081125438  63 RKKFGLVTQADLKTMGY---TSHYAISKAVKAGRFQRLRHGVYALPRADPDA-----IRAVKLG--GAIACESACRRYGI 132
Cdd:COG5340     3 TQGRGVFTTADARAAGLsagISRRLLSRLVKKGELERVRRGLYVLPPAEADKehdelLIAARLVppGYISLLSALALHGL 82

                          90       100
                  ....*....|....*....|....*...
gi 1081125438 133 --WVPHQgLHMAVQRNQTTSRPQGVTIH 158
Cdd:COG5340    83 tdQIPFT-VYVAVPRRSRPIKIGGPPIR 109
MTES_1575 pfam18741
REase_MTES_1575; Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase ...
 231-297 8.02e-05

REase_MTES_1575; Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase and wHTH.


Pssm-ID: 465853  Cd Length: 96  Bit Score: 40.92  E-value: 8.02e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1081125438 231 ETRVRLFLLSNRVHVQPQVyipSVG--RVDM-VAGSS----LILECNGDLAHSTKEQRNRDYIRIQNARLLGYE 297
Cdd:pfam18741   2 EEEVAEALRERGYRVVPQV---GVGgyRIDLvVVDPPgryrLGIECDGATYHSSKSARDRDRLRQRVLERLGWK 72
 
Name Accession Description Interval E-value
YcjD COG2852
Very-short-patch-repair endonuclease [Replication, recombination and repair];
219-324 4.59e-10

Very-short-patch-repair endonuclease [Replication, recombination and repair];


Pssm-ID: 442100  Cd Length: 104  Bit Score: 56.03  E-value: 4.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081125438 219 LRRAspfsESGLETRVRLFLLSNR---VHVQPQVYIPSvGRVDMV-AGSSLILECNGDlAHSTKEQRNRDYIRIQNARLL 294
Cdd:COG2852     1 LRRN----DTPAERRLWQRLRNRQlrgLKFRRQVPIGG-YIVDFYcPEARLAIEVDGG-YHGSPEQRERDRRRDAYLERL 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 1081125438 295 GYETVSLSYAQIFWQWEETQAYLLALIRQR 324
Cdd:COG2852    75 GWRVLRFWNEDVLRNPEGVLEEILAALEER 104
AbiEi_4 pfam13338
Transcriptional regulator, AbiEi antitoxin; AbiEi_4 is the cognate antitoxin of the type IV ...
 62-105 7.44e-07

Transcriptional regulator, AbiEi antitoxin; AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.


Pssm-ID: 463849  Cd Length: 49  Bit Score: 45.23  E-value: 7.44e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1081125438  62 ARKKFGLVTQADLKTMGYtSHYAISKAVKAGRFQRLRHGVYALP 105
Cdd:pfam13338   7 AARQKGIFTTADLAAAGI-SRRALRRLVRKGLLERLRRGVYALP 49
AbiEi COG5340
Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system ...
 63-158 1.54e-05

Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system [Defense mechanisms];


Pssm-ID: 444124 [Multi-domain]  Cd Length: 203  Bit Score: 44.99  E-value: 1.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081125438  63 RKKFGLVTQADLKTMGY---TSHYAISKAVKAGRFQRLRHGVYALPRADPDA-----IRAVKLG--GAIACESACRRYGI 132
Cdd:COG5340     3 TQGRGVFTTADARAAGLsagISRRLLSRLVKKGELERVRRGLYVLPPAEADKehdelLIAARLVppGYISLLSALALHGL 82

                          90       100
                  ....*....|....*....|....*...
gi 1081125438 133 --WVPHQgLHMAVQRNQTTSRPQGVTIH 158
Cdd:COG5340    83 tdQIPFT-VYVAVPRRSRPIKIGGPPIR 109
MTES_1575 pfam18741
REase_MTES_1575; Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase ...
 231-297 8.02e-05

REase_MTES_1575; Vsr REase Fold. Fused to HEPN (SWT1/Abi2 family), along with Transglutaminase and wHTH.


Pssm-ID: 465853  Cd Length: 96  Bit Score: 40.92  E-value: 8.02e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1081125438 231 ETRVRLFLLSNRVHVQPQVyipSVG--RVDM-VAGSS----LILECNGDLAHSTKEQRNRDYIRIQNARLLGYE 297
Cdd:pfam18741   2 EEEVAEALRERGYRVVPQV---GVGgyRIDLvVVDPPgryrLGIECDGATYHSSKSARDRDRLRQRVLERLGWK 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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