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Conserved domains on  [gi|1081357670|gb|OFU95558|]
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ABC transporter permease [Morganella sp. HMSC11D09]

Protein Classification

ABC transporter permease( domain architecture ID 10008325)

ABC transporter permease is the transmembrane subunit found in a periplasmic binding protein (PBP)-dependent ABC transport system, which may be involved in the transport of one or more from a variety of substrates including sugars, ions, amino acids, and peptides, among others

Gene Ontology:  GO:0043190|GO:0140359|GO:0042626|GO:0016020
PubMed:  18535149|25750732|24638992|17723295
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4132 COG4132
ABC-type uncharacterized transport system, permease component [General function prediction ...
 33-286 6.43e-126

ABC-type uncharacterized transport system, permease component [General function prediction only];


:

Pssm-ID: 443307 [Multi-domain]  Cd Length: 286  Bit Score: 359.89  E-value: 6.43e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  33 QLAPMLWVIINSFVYED-AWSFGNFTEIFSsPFYIQSFENTLWISGVSAVGGLILAALFAASLQHVPPRP-RRWLIAFTN 110
Cdd:COG4132    29 LLLPTVWVVIGAFQDDDgGFTLANYAELTS-PFYLQAFWNSIWLSLASALIGAVIGLLLAYALRRGGPGWlRRAVLAFSG 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 111 MTGNFSGVPLAFAFIIILGVNGAITLQLKAWGV--IEDFNLYSAAGLMLIYLYFQIPLGILLLYPAFDALKPEWEDAAKT 188
Cdd:COG4132   108 VASNFAGVPLAFAFIATLGRNGLVTLLLKQLGIdlYDGFNLYSFWGLILVYLYFQIPLMVLLLYPALDGLRREWREAAAL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 189 MGAGRPAYWRYVALPVLSPALLGTFIILFANAAGAYASTYALTTGNYNMVTIRIASLVSGDLFLEPNMAAALSVLLMVIL 268
Cdd:COG4132   188 LGASRWQYWRRVALPVLAPSLLGTFLLLFANAFGAYATAYALTGGNYNLVPIRIGALISGDVLLDPNLGAALALGMIVIM 267

                         250
                  ....*....|....*...
gi 1081357670 269 GFITAVYHWLLKRSYHAK 286
Cdd:COG4132   268 ALVMALYQWLQRRSRRWL 285
 
Name Accession Description Interval E-value
COG4132 COG4132
ABC-type uncharacterized transport system, permease component [General function prediction ...
 33-286 6.43e-126

ABC-type uncharacterized transport system, permease component [General function prediction only];


Pssm-ID: 443307 [Multi-domain]  Cd Length: 286  Bit Score: 359.89  E-value: 6.43e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  33 QLAPMLWVIINSFVYED-AWSFGNFTEIFSsPFYIQSFENTLWISGVSAVGGLILAALFAASLQHVPPRP-RRWLIAFTN 110
Cdd:COG4132    29 LLLPTVWVVIGAFQDDDgGFTLANYAELTS-PFYLQAFWNSIWLSLASALIGAVIGLLLAYALRRGGPGWlRRAVLAFSG 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 111 MTGNFSGVPLAFAFIIILGVNGAITLQLKAWGV--IEDFNLYSAAGLMLIYLYFQIPLGILLLYPAFDALKPEWEDAAKT 188
Cdd:COG4132   108 VASNFAGVPLAFAFIATLGRNGLVTLLLKQLGIdlYDGFNLYSFWGLILVYLYFQIPLMVLLLYPALDGLRREWREAAAL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 189 MGAGRPAYWRYVALPVLSPALLGTFIILFANAAGAYASTYALTTGNYNMVTIRIASLVSGDLFLEPNMAAALSVLLMVIL 268
Cdd:COG4132   188 LGASRWQYWRRVALPVLAPSLLGTFLLLFANAFGAYATAYALTGGNYNLVPIRIGALISGDVLLDPNLGAALALGMIVIM 267

                         250
                  ....*....|....*...
gi 1081357670 269 GFITAVYHWLLKRSYHAK 286
Cdd:COG4132   268 ALVMALYQWLQRRSRRWL 285
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 71-267 2.31e-10

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 58.44  E-value: 2.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  71 NTLWISGVSAVGGLILAALFAASLQHVPPRPRRWLIAFTNMTGNFSGVPLAFAFIIILGVNGAitlqlkaWGVIEDFNLY 150
Cdd:cd06261     3 NTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLG-------WGILPGLGLP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 151 SAAGLMLiylyFQIPLGILLLYPAFDALKPEWEDAAKTMGAGRPAYWRYVALPVLSPALLGTFIILFANAAGAYASTYAL 230
Cdd:cd06261    76 ALILALL----LIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFL 151

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1081357670 231 TTGNYNMVTIRIASLVSGDLFLEPNMAAALSVLLMVI 267
Cdd:cd06261   152 GGGEAPGPGTGLLLIFAILFPGDLGVAAAVALILLLL 188
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 34-286 2.74e-08

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 54.30  E-value: 2.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  34 LAPMLWVIINSFVYED--AWSFGNFTEIFSSPFYIQSFENTLWISGVSAVGGLILAALFAASLQhvpprprRWLIAFTNM 111
Cdd:TIGR03262  19 LLPLLALLTKSVYDSDgdFIGLANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAFAFAYALT-------RSRIPGKGA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 112 TGNFSGVPL-------AFAFIIILGVNGAITlqlkawGVIEDFNLYSAAGLMLIYLYFQIPLGILLLYPAFDALKPEWED 184
Cdd:TIGR03262  92 FRLVALLPLlapsllpAISLIYLFGNQGLLK------GLLGGFSIYGFWGIVIGEVFYTFPHALMILVTALSLADGRLYE 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 185 AAKTMGAGRPAYWRYVALPVLSPALLGTFIILFanaagayasTYALTT--------GNYNMVTIRIASLVSGDLFLEpnM 256
Cdd:TIGR03262 166 AARAMGASPWRTFFTVTLPGAKYGLISAAFVVF---------TLVITDfgvpkvigGDYNVLATDIYKQVIGQQNFP--M 234

                         250       260       270
                  ....*....|....*....|....*....|
gi 1081357670 257 AAALSVLLMVILGFITAVYHWLLKRSYHAK 286
Cdd:TIGR03262 235 GAVVGVLLLLPALLAFGIDRAIQRRQRAQL 264
PRK15050 PRK15050
2-aminoethylphosphonate transport system permease PhnU; Provisional
 36-210 8.67e-07

2-aminoethylphosphonate transport system permease PhnU; Provisional


Pssm-ID: 237888 [Multi-domain]  Cd Length: 296  Bit Score: 49.23  E-value: 8.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  36 PMLWVIINSFVYEDAWSFGNFTEIFSSPFYIQSFENTLWISGVSAVGGLILAALFAASLQHVPPRPRRWLIAFTNMTGNF 115
Cdd:PRK15050   42 PLVRVVLQSLTGEHGLGLATYRAVLGSPDFRGALLTTLQIAFASTAGCLVLGVLLALVLAFVPFPGASLVGRFIDTFVAF 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 116 SGVPLAFAFIIILGVNGAITLQLKAWGVIE----DFnLYSAAGLMLIYLYFQIPLGILLLYPAFDALKPEWEDAAKTMGA 191
Cdd:PRK15050  122 PSFLITLAFTFLYGSAGSVNIALQRLFGLEapplDF-LYSPGGVILAEITFYTPFVVRPLLAAFAQLDARQLEAAASLGA 200

                         170
                  ....*....|....*....
gi 1081357670 192 GRPAYWRYVALPVLSPALL 210
Cdd:PRK15050  201 SPWRVARRVILPEAWPALA 219
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 85-281 1.25e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 44.98  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  85 ILAALFAASlqHVPPRPRRWLIAFTNMtgnFSGVPLAFAFIIILGVNGAITLQLKAWGVIedfnlysaaglmLIYLYFQI 164
Cdd:pfam00528   2 IPLGIIAAL--RRGRRLDRLLRPLIDL---LQALPSFVLAILLVVIAILSILGHGILPAI------------ILALLGWA 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 165 PLGILLLYPAFDALKPEWEDAAKTMGAGRPAYWRYVALPVLSPALLGTFIILFANAAGAYASTYALTTGNYNMVTIRIAS 244
Cdd:pfam00528  65 GYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAI 144

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1081357670 245 LvSGDLFLEPNMAAALSVLLMVILGFITAVYHWLLKR 281
Cdd:pfam00528 145 L-GYDYPEIQGPVLAAALILLLLNLLVDILQRLLDPR 180
 
Name Accession Description Interval E-value
COG4132 COG4132
ABC-type uncharacterized transport system, permease component [General function prediction ...
 33-286 6.43e-126

ABC-type uncharacterized transport system, permease component [General function prediction only];


Pssm-ID: 443307 [Multi-domain]  Cd Length: 286  Bit Score: 359.89  E-value: 6.43e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  33 QLAPMLWVIINSFVYED-AWSFGNFTEIFSsPFYIQSFENTLWISGVSAVGGLILAALFAASLQHVPPRP-RRWLIAFTN 110
Cdd:COG4132    29 LLLPTVWVVIGAFQDDDgGFTLANYAELTS-PFYLQAFWNSIWLSLASALIGAVIGLLLAYALRRGGPGWlRRAVLAFSG 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 111 MTGNFSGVPLAFAFIIILGVNGAITLQLKAWGV--IEDFNLYSAAGLMLIYLYFQIPLGILLLYPAFDALKPEWEDAAKT 188
Cdd:COG4132   108 VASNFAGVPLAFAFIATLGRNGLVTLLLKQLGIdlYDGFNLYSFWGLILVYLYFQIPLMVLLLYPALDGLRREWREAAAL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 189 MGAGRPAYWRYVALPVLSPALLGTFIILFANAAGAYASTYALTTGNYNMVTIRIASLVSGDLFLEPNMAAALSVLLMVIL 268
Cdd:COG4132   188 LGASRWQYWRRVALPVLAPSLLGTFLLLFANAFGAYATAYALTGGNYNLVPIRIGALISGDVLLDPNLGAALALGMIVIM 267

                         250
                  ....*....|....*...
gi 1081357670 269 GFITAVYHWLLKRSYHAK 286
Cdd:COG4132   268 ALVMALYQWLQRRSRRWL 285
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 34-282 2.99e-35

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 128.34  E-value: 2.99e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  34 LAPMLWVIINSF-------VYEDAWSFGNFTEIFSSPFYIQSFENTLWISGVSAVGGLILAALFAASLQHVPPRPRRWLI 106
Cdd:COG1176    27 VLPLLLLLVYSFttrdpygGVVPGFTLENYARLFTDPLYLKVLLRTLWIALLTTLICLLLGYPIAYFLARAPPRWRNLLL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 107 AFTNMTGNFSGVPLAFAFIIILGVNGAITLQLKAWGVIEDFN--LYSAAGLMLIYLYFQIPLGILLLYPAFDALKPEWED 184
Cdd:COG1176   107 LLVILPFWTSFLVRTYAWIVLLGRNGLLNSLLLALGLIDEPLrlLYTEFAVVIGLVYVYLPFMVLPLYAALEKIDPSLLE 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 185 AAKTMGAGRPAYWRYVALPVLSPALLGTFIILFANAAGAYASTYALTTGNYNMVTIRIASLVSGdlFLEPNMAAALSVLL 264
Cdd:COG1176   187 AARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVTPALLGGGKVLMIGNLIYQQFLS--ALNWPLAAALAVVL 264

                         250
                  ....*....|....*...
gi 1081357670 265 MVILGFITAVYHWLLKRS 282
Cdd:COG1176   265 LLIVLLVLLLYLRLLRRR 282
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
34-281 2.13e-27

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 111.02  E-value: 2.13e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  34 LAPMLWVIINSFVYEdawsFGNFTEIFSSPFYIQSFENTLWISGVSAVGGLILAALFAASLQHVPPRPRRWLIAFTNMTG 113
Cdd:COG1178    25 LLPLLALLLRAFTDG----LANFWALLSDPYLWRALGNTLLLALLVTLLSLLLGVPLAWLLARTDFPGRRLLRWLLLLPL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 114 NFSGVPLAFAFIIILGVNGAITLQLKAWGVIEDFNLYSAAGLMLIYLYFQIPLGILLLYPAFDALKPEWEDAAKTMGAGR 193
Cdd:COG1178   101 ALPPYVVALAWIALFGPNGLLNTLLRALFGLEPPDIYGLGGIILVLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 194 PAYWRYVALPVLSPALLGTFIILFANAAGAYAsTYALTTGNYNMVTIRIASLVSGDlfLEPNMAAALSVLLMVILGFITA 273
Cdd:COG1178   181 WRAFRRVTLPLLRPAIAAGALLVFLLCLADFG-TPLVLGGGYTTLTTAIYQAWLGD--FDLGAAAALALVLLLLVLLLLL 257


                  ....*...
gi 1081357670 274 VYHWLLKR 281
Cdd:COG1178   258 LERRLRRR 265
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
34-282 1.06e-24

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 102.93  E-value: 1.06e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  34 LAPMLWVIINSFV--YEDAWSFGNFTEIFSSPFYIQSFENTLWISGVSAVGGLILAALFAASLQHVPPRPRRWLIAFTNM 111
Cdd:COG1178   303 LLPLLALLLWSLTkaLDDNLTLDNYRFVLLDPSLLRALLNSLLLALLAALLAVLLALLLAYLVRRRRGRLARLLDRLAML 382

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 112 TGNFSGVPLAFAFIIilgvngaitlqlkAWGVIEDFNLYSAAGLMLI-YLYFQIPLGILLLYPAFDALKPEWEDAAKTMG 190
Cdd:COG1178   383 PYAVPGIVLGLGLLL-------------LFNRPLPLLLYGTLAILVLaYVVRFLPFALRSLEAALAQIDPSLEEAARSLG 449

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 191 AGRPAYWRYVALPVLSPALLGTFIILFANAAGAYASTYALTTGNYNMVTIRIASLVSGDLFlepNMAAALSVLLMVILGF 270
Cdd:COG1178   450 ASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELSATLLLRPPGFETLAVLIYQLASSGRY---GEAAALALLLVLVSLL 526

                         250
                  ....*....|..
gi 1081357670 271 ITAVYHWLLKRS 282
Cdd:COG1178   527 PVLLLERLLGRR 538
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 34-286 1.62e-19

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 85.55  E-value: 1.62e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  34 LAPMLWVIINSFVYE-------DAWSFGNFTEIFSSPFYIQSFENTLWISGVSAVGGLILAALFAASLQHVPPRPRRWLI 106
Cdd:COG1177    21 YLPILVLVLYSFNDSwfltfppEGFTLRWYAELFSDPRLLDALLNSLLIALLSTLLATVLGTPAALALARYRFRGRRLLL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 107 AFTNMTGNFSGVPLAFAFIIILGvngAITLQLKAWGVIedfnlysaaglmLIYLYFQIPLGILLLYPAFDALKPEWEDAA 186
Cdd:COG1177   101 ALLLLPLVVPGIVLGVALLLLFS---ALGLSGGLWGLI------------LAHVVFTLPFVVLVVLARLQGFDPSLEEAA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 187 KTMGAGRPAYWRYVALPVLSPALLGTFIILFANAAGAYASTYALTTGNYNMVTIRIASLVSGDLflePNMAAALSVLLMV 266
Cdd:COG1177   166 RDLGASPWQTFRRVTLPLIAPGILAGALLAFTLSFDEFVITLFLAGPGVTTLPVYIYSMIRRGI---SPEINALSTLLIL 242

                         250       260
                  ....*....|....*....|
gi 1081357670 267 ILGFITAVYHWLLKRSYHAK 286
Cdd:COG1177   243 LSLLLLLLAERLRRRGERRR 262
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 34-271 3.09e-16

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 76.67  E-value: 3.09e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  34 LAPMLWVIINSFVYEDA------------WSFGNFTEIFSSPFYIQSFENTLWISGVSAVGGLILAALFAASLQHVPPRP 101
Cdd:COG0395    29 LFPLYWMVVTSFKPPAEifsgppsllpseFTLENYRAAFTDGPFGRYLLNSLIVAVVSTVLSLLLSSLAAYALARFRFRG 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 102 RRWLIAftnmtgnfsgvpLAFAFIIILGVNGAITLQLkawgVIEDFNLY-SAAGLMLIYLYFQIPLGILLLYPAFDALKP 180
Cdd:COG0395   109 RKLLFL------------LILATLMIPGQVLLIPLYL----LFRQLGLLnTYWGLILPYLAFGLPFGIFLLRQFFRSIPR 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 181 EWEDAAKTMGAGRPAYWRYVALPVLSPALLGTFIILFANAAGAYASTYALTTGNYNM-VTIRIASLVSGDLFLEPNMAAA 259
Cdd:COG0395   173 ELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRtLPVGLASFQGQYGTDWGLLMAA 252

                         250
                  ....*....|....
gi 1081357670 260 --LSVLLMVILGFI 271
Cdd:COG0395   253 avIATLPVLILFLF 266
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
28-282 6.26e-15

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 73.25  E-value: 6.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  28 LFALFQLAPMLWVIINSFVYEDAWS-------FGNFTEIFSSPFYIQSFENTLWISGVSAVGGLILaALFAASLQHVPPR 100
Cdd:COG1175    30 LLLVFVLYPLLYTLYLSFTDWNLLGpppefvgLDNYARLFTDPRFWNALGNTLLFTVVSVPLQLVL-GLLLALLLNRKLR 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 101 PR---RWLIAFTNMTgnfSGVPLAFAFIIILGVN--------GAITLQLKAWGVIEDFNLYSaagLMLIYLYFQIPLGIL 169
Cdd:COG1175   109 GRgffRTLFFLPWVI---SPVVVALIWKWLFNPDygllnallGALGLEPINWLGDPSLALPA---VIIVTVWKGTGFNML 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 170 LLYPAFDALKPEWEDAAKTMGAGRPAYWRYVALPVLSPALLGTFIILFANAAGAYASTYALTTGNYNMVTIRIASLVSGD 249
Cdd:COG1175   183 IFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGPGNSTTTLVLYIYQT 262

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1081357670 250 LFLEPNM--AAALSVLLMVILGFITAVYHWLLKRS 282
Cdd:COG1175   263 AFQQFDFgyASAIAVVLFLIILVLTLLQLRLLRRR 297
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 71-267 2.31e-10

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 58.44  E-value: 2.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  71 NTLWISGVSAVGGLILAALFAASLQHVPPRPRRWLIAFTNMTGNFSGVPLAFAFIIILGVNGAitlqlkaWGVIEDFNLY 150
Cdd:cd06261     3 NTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLG-------WGILPGLGLP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 151 SAAGLMLiylyFQIPLGILLLYPAFDALKPEWEDAAKTMGAGRPAYWRYVALPVLSPALLGTFIILFANAAGAYASTYAL 230
Cdd:cd06261    76 ALILALL----LIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFL 151

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1081357670 231 TTGNYNMVTIRIASLVSGDLFLEPNMAAALSVLLMVI 267
Cdd:cd06261   152 GGGEAPGPGTGLLLIFAILFPGDLGVAAAVALILLLL 188
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 34-286 2.74e-08

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 54.30  E-value: 2.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  34 LAPMLWVIINSFVYED--AWSFGNFTEIFSSPFYIQSFENTLWISGVSAVGGLILAALFAASLQhvpprprRWLIAFTNM 111
Cdd:TIGR03262  19 LLPLLALLTKSVYDSDgdFIGLANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAFAFAYALT-------RSRIPGKGA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 112 TGNFSGVPL-------AFAFIIILGVNGAITlqlkawGVIEDFNLYSAAGLMLIYLYFQIPLGILLLYPAFDALKPEWED 184
Cdd:TIGR03262  92 FRLVALLPLlapsllpAISLIYLFGNQGLLK------GLLGGFSIYGFWGIVIGEVFYTFPHALMILVTALSLADGRLYE 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 185 AAKTMGAGRPAYWRYVALPVLSPALLGTFIILFanaagayasTYALTT--------GNYNMVTIRIASLVSGDLFLEpnM 256
Cdd:TIGR03262 166 AARAMGASPWRTFFTVTLPGAKYGLISAAFVVF---------TLVITDfgvpkvigGDYNVLATDIYKQVIGQQNFP--M 234

                         250       260       270
                  ....*....|....*....|....*....|
gi 1081357670 257 AAALSVLLMVILGFITAVYHWLLKRSYHAK 286
Cdd:TIGR03262 235 GAVVGVLLLLPALLAFGIDRAIQRRQRAQL 264
thiP TIGR01253
thiamine ABC transporter, permease protein; The model describes thiamine ABC transporter, ...
 72-266 7.36e-07

thiamine ABC transporter, permease protein; The model describes thiamine ABC transporter, permease protein in bacteria. The protein belongs to the larger ABC transport system. It consists of atleast three components: the inner mebrane permease; thiamine binding protein; an ATP-binding subunit. It has been experimentally demonstrated that the mutants in the various steps in the de novo synthesis of the thiamine and the biologically active form, namely thiamine pyrophosphate can be exogenously supplemented with thiamine, thiamine monophosphate (TMP) or thiamine pyrophosphate (TPP). [Transport and binding proteins, Other]


Pssm-ID: 130320 [Multi-domain]  Cd Length: 519  Bit Score: 49.92  E-value: 7.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  72 TLWISGVSAVGGLILAALFAASLQHVPPRPRRWLIAFTNMTGNFSGVPLAFAFIIILGVNGAITLQLKAWGVIEDFNLYS 151
Cdd:TIGR01253  52 SFGQAFLSALLSIFFAIFLARALFRKPFLGKKALLKLCALTFILPALVAIFGIIGIYGRQGWLATLANLFGLEWQFHIYG 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 152 AAGLMLIYLYFQIPLGILLLYPAFDALKPEWEDAAKTMGAGRPAYWRYVALPVLSPALLGTFIILFANAAGAYASTYALT 231
Cdd:TIGR01253 132 LQGILIAHLFFNIPLAAQLFLQALENIPGEQRQLAAQLGLQGWHFFKFVEWPVFRQQCLPTAALIFMLCFASFATVLSLG 211

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1081357670 232 TG-NYNMVTIRIASLVSGDlfLEPNMAAALSVLLMV 266
Cdd:TIGR01253 212 GGpQATTIELAIYQAILFD--FDLAKAALFALLQFV 245
PRK15050 PRK15050
2-aminoethylphosphonate transport system permease PhnU; Provisional
 36-210 8.67e-07

2-aminoethylphosphonate transport system permease PhnU; Provisional


Pssm-ID: 237888 [Multi-domain]  Cd Length: 296  Bit Score: 49.23  E-value: 8.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  36 PMLWVIINSFVYEDAWSFGNFTEIFSSPFYIQSFENTLWISGVSAVGGLILAALFAASLQHVPPRPRRWLIAFTNMTGNF 115
Cdd:PRK15050   42 PLVRVVLQSLTGEHGLGLATYRAVLGSPDFRGALLTTLQIAFASTAGCLVLGVLLALVLAFVPFPGASLVGRFIDTFVAF 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 116 SGVPLAFAFIIILGVNGAITLQLKAWGVIE----DFnLYSAAGLMLIYLYFQIPLGILLLYPAFDALKPEWEDAAKTMGA 191
Cdd:PRK15050  122 PSFLITLAFTFLYGSAGSVNIALQRLFGLEapplDF-LYSPGGVILAEITFYTPFVVRPLLAAFAQLDARQLEAAASLGA 200

                         170
                  ....*....|....*....
gi 1081357670 192 GRPAYWRYVALPVLSPALL 210
Cdd:PRK15050  201 SPWRVARRVILPEAWPALA 219
thiP PRK09433
thiamine transporter membrane protein; Reviewed
 54-217 3.51e-06

thiamine transporter membrane protein; Reviewed


Pssm-ID: 181853 [Multi-domain]  Cd Length: 525  Bit Score: 47.91  E-value: 3.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  54 GNFTEIFSSPFYIQSFENTLWISGVSAVGGLILAALFAASLQHVPPRPRRWLIAFTNMTGNFSGVPLAFAFIIILGVNGA 133
Cdd:PRK09433   31 GDWDAVWQDSYLWHVLRFSFWQAFLSALLSVLPAIPLARALYRRRFPGRGLLLRLCAMTLVLPVLVAVFGLLSVYGRSGW 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 134 ITLQLKAWGVIEDFNLYSAAGLMLIYLYFQIPLGILLLYPAFDALKPEWEDAAKTMGAGRPAYWRYVALPVLSPALLGTF 213
Cdd:PRK09433  111 LAQLLQALGLEWPFSIYGLQGILLAHVFFNLPLATRLLLQALESIPAEQRQLAAQLGMRGWQFFRLVEWPYLRRQLPPVA 190


                  ....
gi 1081357670 214 IILF 217
Cdd:PRK09433  191 ALIF 194
potB PRK09497
spermidine/putrescine ABC transporter membrane protein; Reviewed
 34-224 3.81e-06

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 181910  Cd Length: 285  Bit Score: 47.37  E-value: 3.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  34 LAPMLWVIINSFVYEDA-------WSFGNFTEIFSsPFYIQSFENTLWISGVSAVGGLILAALFAASLQHVPPRPRRWLI 106
Cdd:PRK09497   24 FLPNLMIIGTSFLTRDDanfvkmvFTLDNYTRLLD-PLYAEVLLHSLNMALIATLACLVLGYPFAWFLAKLPHKVRPLLL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 107 AFTNMTGNFSGVPLAFAFIIILGVNGAITLQLKAWGVIED--FNLYSAAGLMLIYLYFQIPLGILLLYPAFDALKPEWED 184
Cdd:PRK09497  103 FLLIVPFWTNSLIRIYGLKIFLSTKGYLNEFLLWLGVIDTpiRIMFTESAVIIGLVYILLPFMVLPLYSSIEKLDKPLLE 182

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1081357670 185 AAKTMGAGRPAYWRYVALPVLSPALLGTFIILFANAAGAY 224
Cdd:PRK09497  183 AARDLGANKLQTFIRIIIPLTMPGIIAGCLLVLLPAMGMF 222
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
55-274 4.72e-06

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 47.13  E-value: 4.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  55 NFTEIFSSPFYIQSFENTLWISGVSAVGGLILAALFAASLQHVPPRPRRWLiafTNMTGNFSGVPLAFAFIIILGVN--- 131
Cdd:PRK10561   43 NFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAALVDYVVRGSRFYQ---TLMLLPYAVAPAVAAVLWIFLFNpgr 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 132 GAITLQLKAWGVIEDFNLYSAAGLMLIYL---YFQIPLGILLLYPAFDALKPEWEDAAKTMGAGRPAYWRYVALPVLSPA 208
Cdd:PRK10561  120 GLITHFLAEFGYDWNHAQNSGQAMFLVVFasvWKQISYNFLFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLIAPV 199

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1081357670 209 llgTFIILFANAAGAYASTY----ALTTGNYNMVTIRIASLVSGDLF--LEPNMAAALSVLLMVILGFITAV 274
Cdd:PRK10561  200 ---SFFLLVVNLVYAFFDTFpvidAATSGGPVQATTTLIYKIYREGFtgLDLSSSAAQSVVLMFLVIVLTVV 268
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 85-281 1.25e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 44.98  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  85 ILAALFAASlqHVPPRPRRWLIAFTNMtgnFSGVPLAFAFIIILGVNGAITLQLKAWGVIedfnlysaaglmLIYLYFQI 164
Cdd:pfam00528   2 IPLGIIAAL--RRGRRLDRLLRPLIDL---LQALPSFVLAILLVVIAILSILGHGILPAI------------ILALLGWA 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 165 PLGILLLYPAFDALKPEWEDAAKTMGAGRPAYWRYVALPVLSPALLGTFIILFANAAGAYASTYALTTGNYNMVTIRIAS 244
Cdd:pfam00528  65 GYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAI 144

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1081357670 245 LvSGDLFLEPNMAAALSVLLMVILGFITAVYHWLLKR 281
Cdd:pfam00528 145 L-GYDYPEIQGPVLAAALILLLLNLLVDILQRLLDPR 180
PRK10971 PRK10971
sulfate/thiosulfate ABC transporter permease CysT;
150-224 4.00e-05

sulfate/thiosulfate ABC transporter permease CysT;


Pssm-ID: 182873  Cd Length: 277  Bit Score: 44.36  E-value: 4.00e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1081357670 150 YSAAGLMLIYLYFQIPLGILLLYPAFDALKPEWEDAAKTMGAGRPAYWRYVALPVLSPALLGTFIILFANAAGAY 224
Cdd:PRK10971  138 YTWLGIAVAMAFTSIPFVVRTVQPVLEELGPEYEEAAETLGATRWQSFRKVVLPELSPALLAGVALSFTRSLGEF 212
YnjC COG4135
ABC-type uncharacterized transport system YnjBCD, permease component [General function ...
 49-273 1.49e-03

ABC-type uncharacterized transport system YnjBCD, permease component [General function prediction only];


Pssm-ID: 443310 [Multi-domain]  Cd Length: 564  Bit Score: 39.85  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670  49 DAWSFGNFTEifSSPFYIQSFENTLWISGVSAVGGLILAALFAASLQHVPPRPRR---WLIAftnmtgnfsgVPL----- 120
Cdd:COG4135   340 SSWTLRFWQR--AAPGLLEPLGNTLLLALASALIALVLVLACLEAEARRGRRPGRralWLLY----------LPLlvpqi 407

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1081357670 121 AFAFiiilgvnGAITLQLKAwgviedFNLYSAAGLMLIYLYFQIPLGILLLYPAFDALKPEWEDAAKTMGAGRPAYWRYV 200
Cdd:COG4135   408 AFLF-------GLQVLLLRL------GLDGTWLAVIWAHLVFVLPYVFLSLAGPWRALDPRYAQVAASLGASPWRVFWRV 474

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1081357670 201 ALPVLSPALLGTFIILFANAAGAYASTYALTTGNYNMVTIRIASLVSGdlfLEPNMAAALSVLLMVI--LGFITA 273
Cdd:COG4135   475 KLPLLLRPILTAAAVGFAVSVAQYLPTLLIGAGRVATLTTEAVALASG---GDRRVIAVYALLQALLplLGFALA 546
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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