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Conserved domains on  [gi|1082558947|gb|OFY92426|]
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hypothetical protein A2236_13390 [Bacteroidetes bacterium RIFOXYA2_FULL_33_7]

Protein Classification

toxin-antitoxin system YwqK family antitoxin( domain architecture ID 11458243)

toxin-antitoxin (TA) system YwqK family antitoxin similar to YwqK (RtbO) antitoxin, the antitoxin component of the YwqJK (RtbNO) TA system that is encoded in the chromosome of Bacillus subtilis subsp. subtilis str. 168

PubMed:  31075979

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
209-372 6.93e-17

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


:

Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 77.42  E-value: 6.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082558947 209 KHECNYANGNIEGEFKGYYPSGNIMLNCNYVNNIIEGEYRLYHDYKNVILIDSLYLKeiGIYNNFKKVGLWKSYYQNGKL 288
Cdd:COG2849     2 KKEGLLKISKYLLSLKLKYELGDTLLEKNGYKSGVKEKTEDSYNEGGKLIKKKLGKG--LGKYKKGKLGEWKTYYPNGQL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082558947 289 HTIGNFVNALYEGEWLVYFEDGTLKQKGSYKNGLENGLWINYYKSGKLNFEGNYIDGKRVGNWKWYYETSKIWKDCSYEN 368
Cdd:COG2849    80 KSEGTYKNGKLEGEWKEYYENGKLKSEGNYKNGKLHGEWKEYYENGKLKEEGNYKNGKKDGVWKYYDENGKLVKEEEYKN 159


                  ....
gi 1082558947 369 GELI 372
Cdd:COG2849   160 GKKV 163
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
22-145 5.06e-14

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


:

Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 69.33  E-value: 5.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082558947  22 KKIKTYYSDKSVKEIFEGKASKKDTIYNGSYEIYYENGKLWQKGQFKDNLLDGFWLDYFEDGKIKQELTYVKGNLEGISK 101
Cdd:COG2849    40 TEDSYNEGGKLIKKKLGKGLGKYKKGKLGEWKTYYPNGQLKSEGTYKNGKLEGEWKEYYENGKLKSEGNYKNGKLHGEWK 119

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1082558947 102 TYYNNGKINQIQAYKNNLLHGKLEIYYTNGILMEESEYYMGILH 145
Cdd:COG2849   120 EYYENGKLKEEGNYKNGKKDGVWKYYDENGKLVKEEEYKNGKKV 163
 
Name Accession Description Interval E-value
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
209-372 6.93e-17

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 77.42  E-value: 6.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082558947 209 KHECNYANGNIEGEFKGYYPSGNIMLNCNYVNNIIEGEYRLYHDYKNVILIDSLYLKeiGIYNNFKKVGLWKSYYQNGKL 288
Cdd:COG2849     2 KKEGLLKISKYLLSLKLKYELGDTLLEKNGYKSGVKEKTEDSYNEGGKLIKKKLGKG--LGKYKKGKLGEWKTYYPNGQL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082558947 289 HTIGNFVNALYEGEWLVYFEDGTLKQKGSYKNGLENGLWINYYKSGKLNFEGNYIDGKRVGNWKWYYETSKIWKDCSYEN 368
Cdd:COG2849    80 KSEGTYKNGKLEGEWKEYYENGKLKSEGNYKNGKLHGEWKEYYENGKLKEEGNYKNGKKDGVWKYYDENGKLVKEEEYKN 159


                  ....
gi 1082558947 369 GELI 372
Cdd:COG2849   160 GKKV 163
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
22-145 5.06e-14

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 69.33  E-value: 5.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082558947  22 KKIKTYYSDKSVKEIFEGKASKKDTIYNGSYEIYYENGKLWQKGQFKDNLLDGFWLDYFEDGKIKQELTYVKGNLEGISK 101
Cdd:COG2849    40 TEDSYNEGGKLIKKKLGKGLGKYKKGKLGEWKTYYPNGQLKSEGTYKNGKLEGEWKEYYENGKLKSEGNYKNGKLHGEWK 119

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1082558947 102 TYYNNGKINQIQAYKNNLLHGKLEIYYTNGILMEESEYYMGILH 145
Cdd:COG2849   120 EYYENGKLKEEGNYKNGKKDGVWKYYDENGKLVKEEEYKNGKKV 163
 
Name Accession Description Interval E-value
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
209-372 6.93e-17

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 77.42  E-value: 6.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082558947 209 KHECNYANGNIEGEFKGYYPSGNIMLNCNYVNNIIEGEYRLYHDYKNVILIDSLYLKeiGIYNNFKKVGLWKSYYQNGKL 288
Cdd:COG2849     2 KKEGLLKISKYLLSLKLKYELGDTLLEKNGYKSGVKEKTEDSYNEGGKLIKKKLGKG--LGKYKKGKLGEWKTYYPNGQL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082558947 289 HTIGNFVNALYEGEWLVYFEDGTLKQKGSYKNGLENGLWINYYKSGKLNFEGNYIDGKRVGNWKWYYETSKIWKDCSYEN 368
Cdd:COG2849    80 KSEGTYKNGKLEGEWKEYYENGKLKSEGNYKNGKLHGEWKEYYENGKLKEEGNYKNGKKDGVWKYYDENGKLVKEEEYKN 159


                  ....
gi 1082558947 369 GELI 372
Cdd:COG2849   160 GKKV 163
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
237-384 4.68e-14

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 69.33  E-value: 4.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082558947 237 NYVNNIIEGEYRLYHDYKNVILIDSLYLKEIGIYNNFKKVGLWKSYYQNGKLHTIGNFVNALYEGEWLVYFEDGTLKQKG 316
Cdd:COG2849     4 EGLLKISKYLLSLKLKYELGDTLLEKNGYKSGVKEKTEDSYNEGGKLIKKKLGKGLGKYKKGKLGEWKTYYPNGQLKSEG 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1082558947 317 SYKNGLENGLWINYYKSGKLNFEGNYIDGKRVGNWKWYYETSKIWKDCSYENGELIYPFNFYDEKGNL 384
Cdd:COG2849    84 TYKNGKLEGEWKEYYENGKLKSEGNYKNGKLHGEWKEYYENGKLKEEGNYKNGKKDGVWKYYDENGKL 151
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
22-145 5.06e-14

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 69.33  E-value: 5.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082558947  22 KKIKTYYSDKSVKEIFEGKASKKDTIYNGSYEIYYENGKLWQKGQFKDNLLDGFWLDYFEDGKIKQELTYVKGNLEGISK 101
Cdd:COG2849    40 TEDSYNEGGKLIKKKLGKGLGKYKKGKLGEWKTYYPNGQLKSEGTYKNGKLEGEWKEYYENGKLKSEGNYKNGKLHGEWK 119

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1082558947 102 TYYNNGKINQIQAYKNNLLHGKLEIYYTNGILMEESEYYMGILH 145
Cdd:COG2849   120 EYYENGKLKEEGNYKNGKKDGVWKYYDENGKLVKEEEYKNGKKV 163
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
19-168 1.05e-12

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 65.47  E-value: 1.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082558947  19 FGQKKIKTYYSDKSVKEIFEGKASKKDTIYNGSYEIYYENGKLWQKGQFKDNLLDGFWLDYFEDGKIKQELTYVKGNLEG 98
Cdd:COG2849    13 LLSLKLKYELGDTLLEKNGYKSGVKEKTEDSYNEGGKLIKKKLGKGLGKYKKGKLGEWKTYYPNGQLKSEGTYKNGKLEG 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082558947  99 ISKTYYNNGKINQIQAYKNNLLHGKLEIYYTNGILMEESEYYMGILHGKSASYFEDGYKRVERFFIEGLE 168
Cdd:COG2849    93 EWKEYYENGKLKSEGNYKNGKLHGEWKEYYENGKLKEEGNYKNGKKDGVWKYYDENGKLVKEEEYKNGKK 162
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
156-348 1.40e-12

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 65.09  E-value: 1.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082558947 156 YKRVERFFIEGLENGDYIEYFENHNIKEKSCKKKGKYDGFFVGYYKEFKDSTVKHECNYANGNIEGEFKGYYPSGNimln 235
Cdd:COG2849     3 KEGLLKISKYLLSLKLKYELGDTLLEKNGYKSGVKEKTEDSYNEGGKLIKKKLGKGLGKYKKGKLGEWKTYYPNGQ---- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082558947 236 cnyvnniiegeyrlyhdyknvilidslyLKEIGIYNNFKKVGLWKSYYQNGKLHTIGNFVNALYEGEWLVYFEDGTLKQK 315
Cdd:COG2849    79 ----------------------------LKSEGTYKNGKLEGEWKEYYENGKLKSEGNYKNGKLHGEWKEYYENGKLKEE 130

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1082558947 316 GSYKNGLENGLWINYYKSGKLNFEGNYIDGKRV 348
Cdd:COG2849   131 GNYKNGKKDGVWKYYDENGKLVKEEEYKNGKKV 163
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
47-178 3.50e-10

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 58.16  E-value: 3.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082558947  47 IYNGSYEIYYENGKLWQKGQFKDNLLDGFWLDYFEDGKIKQELTYVKGNLEGISKTYYNNGKINQIQAYKNNLLHGKLEI 126
Cdd:COG2849    17 KLKYELGDTLLEKNGYKSGVKEKTEDSYNEGGKLIKKKLGKGLGKYKKGKLGEWKTYYPNGQLKSEGTYKNGKLEGEWKE 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1082558947 127 YYTNGILMEESEYYMGILHGKSASYFEDGYKRVERFFIEGLENGDYIEYFEN 178
Cdd:COG2849    97 YYENGKLKSEGNYKNGKLHGEWKEYYENGKLKEEGNYKNGKKDGVWKYYDEN 148
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
143-296 1.31e-07

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 50.84  E-value: 1.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082558947 143 ILHGKSASYFEDGYKRVERFFIEGLENGDYIEYFENHNIKEKSCKKKGKYDGFFVGYYKEF-KDSTVKHECNYANGNIEG 221
Cdd:COG2849    13 LLSLKLKYELGDTLLEKNGYKSGVKEKTEDSYNEGGKLIKKKLGKGLGKYKKGKLGEWKTYyPNGQLKSEGTYKNGKLEG 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1082558947 222 EFKGYYPSGNIMLNCNYVNNIIEGEYRLYHDYKNvilidslyLKEIGIYNNFKKVGLWKSYYQNGKLHTIGNFVN 296
Cdd:COG2849    93 EWKEYYENGKLKSEGNYKNGKLHGEWKEYYENGK--------LKEEGNYKNGKKDGVWKYYDENGKLVKEEEYKN 159
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
62-241 2.70e-05

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 44.29  E-value: 2.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082558947  62 WQKGQFKDNLLDGFWLDYFEDGKIKQELTYVKGNLEGISKTYYNNGKINQI------QAYKNNLLHGKLEIYYTNGILME 135
Cdd:COG2849     2 KKEGLLKISKYLLSLKLKYELGDTLLEKNGYKSGVKEKTEDSYNEGGKLIKkklgkgLGKYKKGKLGEWKTYYPNGQLKS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082558947 136 ESEYYMGILHGKSASYFEDGYKRVERFFIEGLENGDYIEYFENhnikeksckkkgkydgffvgyykefkdSTVKHECNYA 215
Cdd:COG2849    82 EGTYKNGKLEGEWKEYYENGKLKSEGNYKNGKLHGEWKEYYEN---------------------------GKLKEEGNYK 134

                         170       180
                  ....*....|....*....|....*.
gi 1082558947 216 NGNIEGEFKGYYPSGNIMLNCNYVNN 241
Cdd:COG2849   135 NGKKDGVWKYYDENGKLVKEEEYKNG 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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