|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
25-438 |
2.04e-105 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 318.02 E-value: 2.04e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 25 LLAALYTAQGLPFGFFTLALPVLMREAGWSLTALGFLQFLAAPWVLKMLWAPVVDHH-----GKRRTWLLSMQLASCALA 99
Cdd:cd17485 1 LLFGLYLAQGLPYGFQSQALPVLLRSAGVSLTAIGLLKLLYLPWVLKFLWAPLVDRYglprlGRRRSWLLPTQLGLALLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 100 LAMALLGFTEGSVALFVAVFAFNLLAATQDVATDGLAVRLLNAQQRGLANGIQVGAYRFGMILGGGLLLWVFAHTSWQVT 179
Cdd:cd17485 81 LALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 180 FLGMALMLALLTLPVWRMQEPPPHvpnadadgataphpveppvaallsasppastvatasEASPDRPQGRRLALLWWHRA 259
Cdd:cd17485 161 LLSLAALYLLLLLPVLFLRELELP------------------------------------QQPPASERGAALKASLRAFL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 260 MRPGVLALACLIFCFRFGDQMAAGLITPFLLDQGLNKADLAVLKGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGFMQA 339
Cdd:cd17485 205 RRPGTRWLLLFLLLYKLGEQGALAMLPPFLVDRGFSLSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 340 AVYGLYVAAAMGLGG--VPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSVGVSLATLGGIAGGMVGDH 417
Cdd:cd17485 285 LLLGLYTLLALGGSGlnWVLLLASLALLHLVGGMITTALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADH 364
|
410 420
....*....|....*....|.
gi 1082763184 418 LGYATAFASGAVVSVIGLLAL 438
Cdd:cd17485 365 LGYAAAFLLFAILSALSVLLL 385
|
|
| MFS_AmpG_like |
cd17486 |
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ... |
29-440 |
1.55e-49 |
|
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 173.17 E-value: 1.55e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 29 LYTAQGLPFGFFTLALPVLMREAGWSLTALGFLQFLAAPWVLKMLWAPVVD-----HHGKRRTWLLSMQLASCALALAMA 103
Cdd:cd17486 4 LGFASGLPYLLTGTTLQAWLKEAGVDLDTIGLFSLVGLPYSLKFLWAPLVDrystpFLGRRRGWILLTQILLMAALIALA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 104 L---LGFTEGSVALFVAVfAFnlLAATQDVATDGLAVRLLNAQQRGLANGIQVGAYRFGMILGGGLLLWVFAHTSWQVTF 180
Cdd:cd17486 84 FldpFTNLVLSALLFLLV-AF--FSATQDIAIDAYRIEALEDKEQGAGAGVRVNGYRIGMLVAGAGALYLADSLSWSAVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 181 LGMALMLALLTLPVWRMQEPPPHVPNADADGATAPHPVEPpvaallsasppastvataseaspdrpqgrrlallWWHRAM 260
Cdd:cd17486 161 LIMAALMGPGILATLFAPEPPRTDPPANSLSETVVAFFAP----------------------------------FKDFFG 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 261 RPGVLALACLIFCFRFGDQMAAGLITPFLLDQGLNKADLAVLKGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGFMQAA 340
Cdd:cd17486 207 QPGALLILAFILLYKLGDAMLGAMATPFLLDLGFTKTEIGAVYKTVGLIATIVGGLLGGFLMSRLGLKRSLWLFGILQAL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 341 VYGLYVAAAMGLGGVPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSV-GVSLATLGGIAGGMVgDHLG 419
Cdd:cd17486 287 SNLGFIYLAHAGPNLTLLVAAVAVENFGGGLGTTAFVAYLMSLCNGEFTATQYALLSSLmALGRMVLGAPSGWLA-EALG 365
|
410 420
....*....|....*....|.
gi 1082763184 420 YATAFASGAVVSVIGLLALVR 440
Cdd:cd17486 366 WTGFFLLTTLAAIPGLLLLLK 386
|
|
| sider_RhtX_FptX |
TIGR02718 |
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from ... |
26-440 |
2.34e-39 |
|
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from Pseudomonas aeruginosa appear to be single polypeptide transporters, from the major facilitator family (see pfam07690) for import of siderophores as a means to import iron. This function was suggested by proximity to siderophore biosynthesis genes and then confirmed by study of knockout and heterologous expression phenotypes. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 131765 Cd Length: 390 Bit Score: 146.19 E-value: 2.34e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 26 LAALYTAQGLPFGFFTLALPVLMREAGWSLTALGFLQFLAAPWVLKMLWAPVVDHH-----GKRRTWLLSMQLASCALAL 100
Cdd:TIGR02718 6 LGLLYLSQGIPIGLAMDALPTLLREDGAPLTALAFLPLVGLPWVVKFLWAPLVDNWwswrlGRRRSWVLPMQCLVSACLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 101 AMALLGFTEGSVALFVAVFAF-NLLAATQDVATDGLAVRLLNAQQRGLANGIQVGAYRFGMILGGGLLLWVFAHTSWQVT 179
Cdd:TIGR02718 86 SLALVGPDVAGAGWAVGLLACaSLASATQDIATDGMAAEHFNGRTLAKGNAVQIAGVMIGFFGGGAGTLVLFGKFGQRPA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 180 FLgmalmlalltlpvwrmqeppphvpnadadgATAPHPVEPPVAALlsasppasTVATASEASPDRPQGRRLALLWWHRa 259
Cdd:TIGR02718 166 FL------------------------------LVACVPLASLVCVL--------WLKDRAVASPEAPLARRASLFRFFR- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 260 mRPGVLALACLIFCFRFGDQMAAGLITPFLLDQGLNKADLAVLKGAVGSGTSLLGAVLGGWLMLRVGRRAAL-LGCGFMQ 338
Cdd:TIGR02718 207 -RPLAWSLLALALLSAMTAVSGFGLSKLYLVDAGWPLEWIGRLGMAGGAVTVLLGCGGGAWLVRRAGLWRTFiLGVGLAG 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 339 AAVYGLYVAAAMGLG-GVPLLWLATVAEGVVGTMATVALYSLMMDSA-DPAHPGTDYTLMGSVGVSLATLGGIAGGMVGD 416
Cdd:TIGR02718 286 SLALLWFAQAAFWLApGIAVAWSCSAFGSLITGITSVAIYTAFMRFAgDGDQAGTDVTAVQSTRDLGELIASSIAGYLTD 365
|
410 420
....*....|....*....|....
gi 1082763184 417 HLGYATAFASGAVVSVIGLLALVR 440
Cdd:TIGR02718 366 RFGYAGGFLSGTVLAVLAILLAVR 389
|
|
| ampG |
PRK11902 |
muropeptide transporter; Reviewed |
26-454 |
1.55e-17 |
|
muropeptide transporter; Reviewed
Pssm-ID: 183369 [Multi-domain] Cd Length: 402 Bit Score: 84.13 E-value: 1.55e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 26 LAALYTAQGLPFGFFTLALPVLMREAGWSLTALGFLQFLAAPWVLKMLWAPVVDHH-----GKRRTWLLSMQLASCALAL 100
Cdd:PRK11902 4 MLLLGFASGLPLALTSGTLQAWMTVEGLDIQTIGFFSLVGQAYIFKFLWAPLMDRYtppllGRRRGWLLLTQVGLAASIA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 101 AMALLGFTEGSVALFVAVFAFNLLAATQDVATDGLAVRLLNAQQRGLANGIQVGAYRFGMILGGGLLLWVFAHT-SWQVT 179
Cdd:PRK11902 84 AMAFCPPHAALWPLAGLAVLVAFLSASQDIVFDAYSTDVLHPEERGAGAAVKVLGYRLAMLVSGGLALWLADRVlGWGNT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 180 FLGmalmlalltlpvwrmqeppphvpnadadgataphpveppVAALLSASPPASTVATASEASPDRPQGRRLALLWWHRA 259
Cdd:PRK11902 164 YLL---------------------------------------MAGLMLAGALTTLWAPEPEVPARPPRSLGEAVVGPLRD 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 260 M--RPGVLALACLIFCFRFGDQMAAGLITPFLL-DQGLNKADLAVLKGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGF 336
Cdd:PRK11902 205 FfsRRGAWALLLLIVLYKLGDAFAGSLSTTFLIrGAGFSAGEVGIVNKTLGLAATIVGALAGGTLMVRLGLYRSLMLFGV 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 337 MQAAVYGLYVAAAMGLGGVPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSVGVSLATLGGIAGGMVGD 416
Cdd:PRK11902 285 LQAVSNLGYWVLAVTPKHLWTMALAIGIENLCGGMGTAAFVALLMALCNRSFSATQYALLSALASVGRVYVGPTSGYLVE 364
|
410 420 430
....*....|....*....|....*....|....*...
gi 1082763184 417 HLGYATAFASGAVVSVIGLLALvrWLDAHPFNQRVRQA 454
Cdd:PRK11902 365 AYGWPGFYLMTVVIALPGLALL--WLMRGTIGRYEAQA 400
|
|
| ampG |
PRK11010 |
muropeptide MFS transporter AmpG; |
32-438 |
1.50e-13 |
|
muropeptide MFS transporter AmpG;
Pssm-ID: 182898 [Multi-domain] Cd Length: 491 Bit Score: 72.37 E-value: 1.50e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 32 AQGLPFGFFTLALPVLMREAGWSLTALGFLQFLAAPWVLKMLWAPVVDHH-----GKRRTWLLSMQLASCALALAMallG 106
Cdd:PRK11010 23 ASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPLMDRYtppflGRRRGWLLATQLLLLVAIAAM---G 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 107 FTEGS-----VALFVAVFAFnlLAATQDVATDGLAVRLLNAQQRGLANGIQVGAYRFGMILGGGLLLWVF-AHTSWQVTF 180
Cdd:PRK11010 100 FLEPGtqlrwLAALAVVIAF--CSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLAMLVSGGLALWLAdRYLGWQGMY 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 181 LGMALMLALLTLPVWRMQEPPPHVPnadadgatAPHPVEPPVAALLSASppastvataseaspdrpQGRRLALLwwhram 260
Cdd:PRK11010 178 WLMAALLIPCIIATLLAPEPTDTIP--------VPKTLEQAVVAPLRDF-----------------FGRNNAWL------ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 261 rpgvlaLACLIFCFRFGDQMAAGLITPFLLDQ-GLNKADLAVLKGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGFMQA 339
Cdd:PRK11010 227 ------ILLLIVLYKLGDAFAMSLTTTFLIRGvGFDAGEVGLVNKTLGLLATIVGALYGGILMQRLSLFRALMIFGILQG 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 340 AVYGLYVAAAMGLGGVPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSV-GVSLATLGGIAGGMVGDHl 418
Cdd:PRK11010 301 VSNAGYWLLSITDKNLYSMGAAVFFENLCGGMGTAAFVALLMTLCNKSFSATQFALLSALsAVGRVYVGPVAGWFVEAH- 379
|
410 420
....*....|....*....|
gi 1082763184 419 GYATAFASGAVVSVIGLLAL 438
Cdd:PRK11010 380 GWPTFYLFSVAAAVPGLLLL 399
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
44-442 |
1.54e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 68.76 E-value: 1.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 44 LPVLMREAGWSLTALGFL--QFLAAPWVLKMLWAPVVDHHGKRRTWLLSMqlasCALALAMALLGFTEGSVALFVAVFAF 121
Cdd:cd17325 19 LPLYAESLGASVAQIGLIvaAYALAQLLFSPPAGRLSDRFGRKRLLLLGL----LLLAVSTLLFAFATSYWQLLLARFLQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 122 NLLAATQDVATDGLAVRLLNAQQRGLANGIQVGAYRFGMILGGGLLLWVFAHTSWQVTFLGMALMLALLTLPVWRMQEPP 201
Cdd:cd17325 95 GLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 202 PHVPNADadgataphpveppvaallsasppastvataseaspdRPQGRRLALLWWHRAMRPGVLALACLIFCFRFGDQMA 281
Cdd:cd17325 175 RPPPNKR------------------------------------AVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGAL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 282 AGLITPFLLDQ-GLNKADLAVLKGAvGSGTSLLGAVLGGWLMLRVGRRAALLGCGFMQAAVYGLYVAAamglGGVPLLWL 360
Cdd:cd17325 219 EPFLPLYAAELgGLSPAQIGLLFGA-QGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA----TSFWLLLL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 361 ATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSVGVSLATLGGIAGGMVGDHLGYATAFASGAVVSVIGLLALVR 440
Cdd:cd17325 294 LLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
..
gi 1082763184 441 WL 442
Cdd:cd17325 374 LR 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
26-407 |
2.08e-12 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 68.21 E-value: 2.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 26 LAALYTAQGLPFGFFTLALPVLMREA-GWSLTALGFLQ--FLAAPWVLKMLWAPVVDHHGKRRTWLLSMqlasCALALAM 102
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLtlFSLGYALAQPLAGRLSDRFGRRRVLLIGL----LLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 103 ALLGFTEGSVALFVAVFAFNLLAATQDVATDGLAVRLLNAQQRGLANGIQVGAYRFGMILGGGLLLWVFAHTSWQVTFLG 182
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 183 MALMLALLTLPVWRMQEPPPHvpnadadgataphpveppvaallsasppastvatasEASPDRPQGRRLALLWWHRAMRP 262
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPES------------------------------------KRPKPAEEARLSLIVAWKALLRD 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 263 GVLALACLIFCFRFGDQMAAGLITPFLLDQGLNKADLAVLkGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGFMQAAVY 342
Cdd:pfam07690 201 PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL-LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAA 279
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1082763184 343 GLYVAAAMGLGGVpLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSVGVSLATLG 407
Cdd:pfam07690 280 LGLLLLSLTLSSL-WLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
26-439 |
3.29e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 64.76 E-value: 3.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 26 LAALYTAQGLPFGFFTLALPVLMREAGWSLTALGFLQ--FLAAPWVLKMLWAPVVDHHGKRRTWLLSMqlasCALALAMA 103
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFalFSLGYALLQPLAGLLADRFGRRPVLLLGL----LLFALGAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 104 LLGFTEGSVALFVAVFAFNLLAATQDVATDGLAVRLLNAQQRGLANGIQVGAYRFGMILGGGLLLWVFAH--TSWQVTFL 181
Cdd:cd06174 77 LFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 182 GMALMLALLTLPVWRMQEPPPHVPNADADGATAPHPVEPpvaallsasppastvataseaspdrpqgrrlallWWHRAMR 261
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKL----------------------------------LKRVLKN 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 262 PGVLALACLIFCFRFGDQMAAGLITPFLLDQGLNKADLAVLKGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGFmqaAV 341
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGL---LL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 342 YGLYVAAAMGLGGVPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSVGVSLATLGGIAGGMVGD-HLGY 420
Cdd:cd06174 280 MALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGL 359
|
410
....*....|....*....
gi 1082763184 421 ATAFASGAVVSVIGLLALV 439
Cdd:cd06174 360 TGAFLVLAVLLLLAAILLL 378
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
23-442 |
1.24e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 59.50 E-value: 1.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 23 LPLLAALYTAQGLPFGFFTLALPVLMREAGWSLTALGFLQ--FLAAPWVLKMLWAPVVDHHGKRRTWLLSMqlasCALAL 100
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLAsaFFLGYALGQIPAGLLADRFGRRRVLAIGL----LLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 101 AMALLGFTEGSVALFVAVFAFNLLAATQDVATDGLAVRLLNAQQRGLANGIQVGAYRFGMILGGGLLLWVFAHTSWQVTF 180
Cdd:COG2271 88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 181 LgmalmlalltlpvwrmqeppphvpnadadgataphpveppVAALLSAsppastvataseaspdrpqgrrLALLWwhram 260
Cdd:COG2271 168 L----------------------------------------ILGLPGL----------------------LLALL----- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 261 rpGVLALACLIFCFRFGDQMAAGLITPFLLDQGLNKADLAVLKGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGFMqaA 340
Cdd:COG2271 181 --RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGL--L 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 341 VYGLYVAAAMGLGGVPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSVGVSLATLGGIAGGMVGDHLGY 420
Cdd:COG2271 257 LAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGY 336
|
410 420
....*....|....*....|..
gi 1082763184 421 ATAFASGAVVSVIGLLALVRWL 442
Cdd:COG2271 337 QAAFLLLAALALLAALLALLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
40-439 |
1.44e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 59.51 E-value: 1.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 40 FTLALPVLMREAGWSLTALGFLqfLAAPWVLKMLWAPV----VDHHGKRRTWLLSMqlasCALALAMALLGFTEGSVALF 115
Cdd:COG2223 24 WSVLAPPLAEEFGLSAAQLGLL--FAIPVLVGALLRIPlgflVDRFGPRRVLLIGL----LLLGIGLLLLALAVSYWLLL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 116 VAVFAFNLLAATQDVATDGLAVRLLNAQQRGLANGIQVGAYRFGMILGGGLLLWVFAHTSWQVTFLGMALMLALLTLPVW 195
Cdd:COG2223 98 LLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAW 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 196 R-MQEPPPHVPNAdadgataphpveppvaallsaspPASTVATASEAspdrpqgrrlallwwhrAMRPGVLALACLIFCF 274
Cdd:COG2223 178 LfLRDPPAGAAAA-----------------------AKASLRDQLEA-----------------LRDPRFWLLSLLYFGT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 275 RFGDQMAAGLITPFLLDQGLNKADLAVLKGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGFMQAAvygLYVAAAMGLGG 354
Cdd:COG2223 218 FGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMAL---GLLLLALALGS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 355 VPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSVGVSLATLGGIAGGMVGDHLG-YATAFASGAVVSVI 433
Cdd:COG2223 295 LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALV 374
|
....*.
gi 1082763184 434 GLLALV 439
Cdd:COG2223 375 ALVLTL 380
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
257-442 |
2.55e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.45 E-value: 2.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 257 HRAMRPGVLALACLIFCFRFGDQMAAGLITPFLLDQGLNKADLAVLkGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGF 336
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLV-VTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 337 MQAAVYGLYVAAamglGGVPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSVGVSLATLGGIAGGMVGD 416
Cdd:COG2814 84 LFALGSLLCALA----PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180
....*....|....*....|....*.
gi 1082763184 417 HLGYATAFASGAVVSVIGLLALVRWL 442
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLL 185
|
|
| Acatn |
pfam13000 |
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to ... |
25-153 |
2.95e-09 |
|
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to 10 transmembrane domains. It appears to promote 9-O-acetylation in gangliosides.
Pssm-ID: 372424 [Multi-domain] Cd Length: 543 Bit Score: 58.91 E-value: 2.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 25 LLAALYTAQGLPFGFFTLALPVLMREAGW--SLTALGFLQFLAAPWVLKMLWAPVVD-----HHGKRRTWLLSMQlASCA 97
Cdd:pfam13000 3 LLVALYFLQGIPVGLAFGTIPFLLKSMAKetSFTSLGIFSMATYPYSLKILWSPIVDsiyskKIGRRRSWIIPVQ-LVSG 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1082763184 98 LALAMALLGFTEGSVALFV-AVFAFN---------------------LLAATQDVATDGLAVRLLNAQQRGLANGIQV 153
Cdd:pfam13000 82 IMLIILGYCISKGLIFPGVdDAFHGRlskgvlnvnittltwyfgilvFLCATQDIAVDGWALTILSKQSLSYASTAQT 159
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
23-400 |
3.37e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.06 E-value: 3.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 23 LPLLAALYTAQGLPFGFFTLALPVLMREAGWSLTALGFLQ--FLAAPWVLKMLWAPVVDHHGKRRTWLLSMqlasCALAL 100
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVtaYLLGAALGAPLAGRLADRFGRRRVLLLGL----LLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 101 AMALLGFTEGSVALFVAVFAFNLLAATQDVATDGLAVRLLNAQQRGLANGIQVGAYRFGMILGGGLLLWVFAHTSWQVTF 180
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 181 LGMAlmlalltlpvwrmqeppphvpnadadgataphpveppVAALLSASPPASTVATASEASPDRPQGRRLALLWwhram 260
Cdd:COG2814 168 LVNA-------------------------------------VLALLALLLLLRLLPESRPAARARLRGSLRELLR----- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 261 RPGVLALACLIFCFRFGDQMAAGLITPFLLDQGLNKADLAVLKGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGFMQAA 340
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 341 VYGLYVAAamglGGVPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSVG 400
Cdd:COG2814 286 GLLLLALA----GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
25-440 |
4.19e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.93 E-value: 4.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 25 LLAALYTAQGLPFGFFTLALPVLMREAGWSLTALGFLQFL-AAPWVLKMLWA-PVVDHHGKRRTWLLSMQLASCALALAM 102
Cdd:cd06173 3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAfFLPFLLFSPFAgVLADRFDRRRLLILADLLRALLAAVLA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 103 ALLGFTEGSV-ALFVAVFAFNLLAATQDVATDGLAVRLLNAQQRGLANGIQVGAYRFGMILGGGLLLWVFAHTSWQVTFL 181
Cdd:cd06173 83 LLALLGSLSLwLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 182 gmalmlalltlpvwrmqeppphvpnadADGATAphpvepPVAALLSASPPASTVATASEASPDRPQGRRLALLWWHRAmR 261
Cdd:cd06173 163 ---------------------------INALSF------LLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRS-P 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 262 PGVLALACLIFCFRFGDQMAAGLITPFLLDQGLNKADLAVLKGAVGSGtSLLGAVLGGWLMLRVGRRAALLGCGFMQAav 341
Cdd:cd06173 209 LLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVG-ALLGALLLGRLSKRRRRGRLLLIGALLLG-- 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 342 yglyvAAAMGLGGVPLLWLATVAE---GVVGTMATVALYSLMMDSADPAHPGTDYTLMGSVGVSLATLGGIAGGMVGDHL 418
Cdd:cd06173 286 -----LALLVLGLSPSLWLLLAALfllGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360
|
410 420
....*....|....*....|..
gi 1082763184 419 GYATAFASGAVVSVIGLLALVR 440
Cdd:cd06173 361 GLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
222-439 |
5.81e-07 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 51.35 E-value: 5.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 222 VAALLSASPPASTVATASEASPDRPQGRRLALLWwhraMRPGVLALACLIFCFRFGDQMAAGLITPF---LLdqGLNKAD 298
Cdd:cd06176 187 LLALWGVERRRSRAALAAEEAPPETFREALRLLW----ASPQARRFFIFLFLSTLALFMQDVILEPFggeVF--GMSVGE 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 299 LAVLKGAVGSGTsLLGAVLGGWLMLRVG--RRAALLGCGFMQAAVYGLYVAAAMGLggVPLLWLATVAEGVVGTMATVAL 376
Cdd:cd06176 261 TTRLTAIWGGGT-LLGMLLAGFLLSRRLgkKRTAALGCLLSALGFLLLALAGLLGN--PWLFRPGVFLLGLGNGLFTVGA 337
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1082763184 377 YSLMMDSADPAHPGtdyTLMGSVGVSLAT---LGGIAGGMVGD---------HLGYATAFASGAVVSVIGLLALV 439
Cdd:cd06176 338 LTLMMDLTGEGTAG---LFMGLWGAAQALargLGTLLGGALRDllralfgspALAYGLVFLLEAVLLLVALLLLR 409
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
267-446 |
6.71e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 51.26 E-value: 6.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 267 LACLIFCFRFGDQMAAGLITPFLLDQ-GLNKADLAVLkGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGFMQAAVYGLY 345
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLL-LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 346 VAAAmglgGVPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSVGVSLATLGGIAGGMVGDHLGYATAFA 425
Cdd:pfam07690 80 LFAS----SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170 180
....*....|....*....|.
gi 1082763184 426 SGAVVSVIGLLALVRWLDAHP 446
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPE 176
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
265-439 |
1.02e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.67 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 265 LALACLIFCFRFGDQMAAGLITPFLLDQ-GLNKADLAVLkGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGFMQAAVYG 343
Cdd:COG2211 231 LLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLL-LALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 344 LYvaAAMGLGGVPLLWLATVAEGVVGTMATVALYSLMMDSADPAH-------PGTDYTLMGSVGVSLATLGGIAGGMVGD 416
Cdd:COG2211 310 LL--FFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
170 180
....*....|....*....|....
gi 1082763184 417 HLGY-ATAFASGAVVSVIGLLALV 439
Cdd:COG2211 388 LFGYvAGAAQSPSALTGIRLLFFL 411
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
267-450 |
4.31e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 48.73 E-value: 4.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 267 LACLIFCFRFGDQMAAGLITPFLLDQGLNKADLAVLkGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGFMQAAVYGLYV 346
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLI-VAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 347 AAAmglgGVPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSVGVSLATLGGIAGGMVGDHLGYATAFAS 426
Cdd:cd17325 80 FAT----SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLV 155
|
170 180
....*....|....*....|....
gi 1082763184 427 GAVVSVIGLLALVRWLDAHPFNQR 450
Cdd:cd17325 156 CAALALLALVLALLLLPEPRPPPN 179
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
243-437 |
1.01e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 47.54 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 243 PDRPQGRRLALLWWHRAMRPGVLALACLIFCFRFGDQMAAGLITPFLLDQGLNKADLAVLKGAVGSGTSLLGAVLGGWLM 322
Cdd:cd17324 179 PKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 323 LRVGRRAALLGCGFMQAAVYGLYVAAAMGLGGVPLLWLATVAEGVVGTMATVALYSLmmdsaDPAHPGTDYTLMGSVGVS 402
Cdd:cd17324 259 DRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL-----APEARGLASSLYLAAYNL 333
|
170 180 190
....*....|....*....|....*....|....*
gi 1082763184 403 LATLGGIAGGMVGDHLGYATAFASGAVVSVIGLLA 437
Cdd:cd17324 334 GGALGAALGGLVLDHGGWAGVGWVGAALLLLALLL 368
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
264-446 |
2.04e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.45 E-value: 2.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 264 VLALACLIFCFRFGDQMAAGLITPFLLDQGLNKADLAVLKGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGFMQAAVYG 343
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 344 LYVAAamglGGVPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTL---MGSVGVslaTLGGIAGGMVGDhLGY 420
Cdd:cd17329 81 LLGFA----HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLlywAINLGV---AIGPLLGGLLLL-YSF 152
|
170 180
....*....|....*....|....*.
gi 1082763184 421 ATAFASGAVVSVIGLLALVRWLDAHP 446
Cdd:cd17329 153 RLLFLAAAVLFLLAALVLLFLLPETR 178
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
275-441 |
2.58e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 2.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 275 RFGDQMAAGLITPFLLDQGLNKADLAVLkGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGFMQAA-VYGLYVAAAMGLG 353
Cdd:cd06173 12 ALGDWIFTVALPWLVLQLTGSALLVGLV-LAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALlAAVLALLALLGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 354 GVPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSVGVSLATLGGIAGGMVGDHLGYATAFASGAVVSVI 433
Cdd:cd06173 91 SLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLL 170
|
....*...
gi 1082763184 434 GLLALVRW 441
Cdd:cd06173 171 SALLLLFI 178
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
286-441 |
2.61e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.02 E-value: 2.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 286 TPFLLDQGLnkADLAVLKGAVGSGTSLLGAV----LGGWLMLRVGRRAALLGCgfmqAAVYGLYVAAAMGLGGVPLLWLA 361
Cdd:cd17474 221 LPFLLELLY--GISPIIIGLLFAGWSVLLALgslfVGRLLKKRFGARRILVIG----LLLYALSLLLLGFVPSLALLLIA 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 362 TVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSVGVSLATLGGIAGGMVGDHLGYATAFASGAVVSVIGLLALVRW 441
Cdd:cd17474 295 IVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
264-442 |
7.05e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 45.04 E-value: 7.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 264 VLALACLIFCFRFGDQMAAGLITPFLL-DQGLNKADLavlkGAVGSGT---SLLGAVLGGWLMLRVGRRAALLGCgfmqA 339
Cdd:TIGR00895 18 AIILSFLIMLMDGYDLAAMGFAAPAISaEWGLDPVQL----GFLFSAGligMAFGALFFGPLADRIGRRRVLLWS----I 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 340 AVYGLYVAAAMGLGGVPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSVGVSLATLGGIAGGMVGDHLG 419
Cdd:TIGR00895 90 LLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFG 169
|
170 180
....*....|....*....|...
gi 1082763184 420 YATAFASGAVVSVIGLLALVRWL 442
Cdd:TIGR00895 170 WRSLFYVGGIAPLLLLLLLMRFL 192
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
258-442 |
1.06e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.09 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 258 RAMRPGVLALACLIFCFRFGDQMAAGLITPFLL-DQGLNKADLAVLkGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGF 336
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQaDLGLSAAQLGLL-ASAFFLGYALGQIPAGLLADRFGRRRVLAIGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 337 MQAAVYGLYVAAamglGGVPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSVGVSLATLGGIAGGMVGD 416
Cdd:COG2271 84 LWGLATLLFGFA----TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180
....*....|....*....|....*.
gi 1082763184 417 HLGYATAFASGAVVSVIGLLALVRWL 442
Cdd:COG2271 160 AFGWRAAFLILGLPGLLLALLRFWLL 185
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
223-440 |
1.21e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 44.13 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 223 AALLSASPPASTVATASEASPDRPQGRRLALLWWHRAM--RPGVLALACLIFCFRFGDQMAAGLITPFLLDQ-GLNKADL 299
Cdd:cd17331 166 IVLVILLIPSNTKSKREKEAKESASPPSVFNLKEILRLlrLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFfGLTPEEN 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 300 AVLKGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGFMQAAVYGLYVAAamglGGVPLLWLATVAEGVVGTMATVALYSL 379
Cdd:cd17331 246 GYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFV----TTVWQLLVLLLPLVIGGSVLYTVITSL 321
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1082763184 380 MMDSADPAHPGTDYTLMGSVGVSLATLGGIAGGMVGDHLGYATAFASGAVVSVIGLLALVR 440
Cdd:cd17331 322 LTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
222-438 |
2.23e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.32 E-value: 2.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 222 VAALLSASPPASTVATASEASPDRPQGRRLALLWwhRAMRPGVLAlaclIFCFRFGDQMAAGLITPFLLDQGLNKADLAV 301
Cdd:cd17477 154 AAVLLLLALVPLLLTRRAAPEIEEAESISLRRLL--RIAPLALLG----AFVAGFLEGAFYSLLPLYGLRLGLSVAQAAL 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 302 LKGAVGSGtSLLGAVLGGWLMLRVGRRAALLGCGFMqAAVYGLYVAAAMGLGGVpLLWLATVAEGVVGTMATVALySLMM 381
Cdd:cd17477 228 LLAAFVLG-GLLLQWPLGWLADRFDRRRVLLGCALL-GALAALLLPLVPGLPLA-LLVLLFLWGGAAGPLYTLAL-ALAG 303
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 382 DSADPAHPGTDYTLMG---SVGvslATLGGIAGGMVGDHLGYATAFASGAVVSVIGLLAL 438
Cdd:cd17477 304 DRLPGDELVAANAALLllyGLG---SVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
310-438 |
2.54e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.97 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 310 TSLLGAVLGGWLMLRVGRRAALLGCGFMQAAVYGLYVAAamglGGVPLLWLATVAEGVVGTMATVALYSLMMDSADPAHP 389
Cdd:cd17489 43 AALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA----TSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRR 118
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1082763184 390 GTDYTLMGSVGVSLATLGGIAGGMVGDHLGYATAFASGAVVSVIGLLAL 438
Cdd:cd17489 119 GEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLV 167
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
261-436 |
8.36e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 41.38 E-value: 8.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 261 RPGVLALACLIFCFRFGDQMAAGLITPFLLDQGLNKADLAVLKGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGFMQAA 340
Cdd:COG0738 209 NPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAV 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 341 VYGLYVAAamglggvPLLWLATVAEGVVGtMATVALYSLMMdSADPAHPGTDYTLMGSVGVSLATLGGIAG----GMVGD 416
Cdd:COG0738 289 GLLLALLA-------PGPWLALIGLALVG-LGLSLMFPTIF-SLALDGLGKRTAAAVSAVLIMGIVGGAIGppliGFLAD 359
|
170 180
....*....|....*....|
gi 1082763184 417 HLGYATAFASGAVVSVIGLL 436
Cdd:COG0738 360 AFGLRAAFLVPLVCYLLILL 379
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
240-436 |
8.86e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.43 E-value: 8.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 240 EASPDRPQGRRLALLWWHRAMRPGVLALACLIFCFRFGDQMAAGLITPFLLDQGLNKADLAVLkgaVGSGTSLLGAVLGG 319
Cdd:cd17489 172 DPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFT---VYAIALLLSRPFSG 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 320 WLMLRVGRRAALLGCGFMQAAvyGLYVAAAMGlgGVPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTD---YTLM 396
Cdd:cd17489 249 KLSDRKGPKTVIIPGLLLLAL--GLLLLSFAG--SPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAAngtFFIF 324
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1082763184 397 GSVGVSLatlGGIAGGMVGDHLGYATAFASGAVVSVIGLL 436
Cdd:cd17489 325 FDLGIGL---GGLLLGLVAELFGYRAMFLLAAVVVLLALV 361
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
260-438 |
1.24e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 41.05 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 260 MRPGVLALACLIFCFRFGDQMAAGLITPFLLDQGLNKADLAVLKGAVGSGTSLLGAVLGGWLMLRVGRRAALLGCGFMqa 339
Cdd:cd17316 175 LRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIL-- 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 340 AVYGLYVAAAMGLGGVPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSVGVSLATLGGIAGGMVGDHLG 419
Cdd:cd17316 253 SGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG 332
|
170
....*....|....*....
gi 1082763184 420 YATAFASGAVVSVIGLLAL 438
Cdd:cd17316 333 GTGVPALILALLAIVALIV 351
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
263-440 |
2.42e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.87 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 263 GVLALACLIFCFRF----------------GDQMAAGLITPFLLDQ-GLNKADLAVLKGAVGSGTSLLGAVLGGWLMLRV 325
Cdd:cd17330 159 AALALLNLVLVLFFlpplrrlllvyflialAFAGLESVFSLFLKDRfGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRL 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 326 GRRAALLGCGFMQAAVYGLYVAAAmglgGVPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTDYTLMGSVGVSLAT 405
Cdd:cd17330 239 GERKLLRLGLLLAIIGLLLLPFAS----SVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARI 314
|
170 180 190
....*....|....*....|....*....|....*
gi 1082763184 406 LGGIAGGMVGDHLGYATAFASGAVVSVIGLLALVR 440
Cdd:cd17330 315 IGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
145-412 |
2.72e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 40.03 E-value: 2.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 145 RGLANGIQVGAYRFGMILGGGLLLWVFAHTSWQVTFLGMALMLALLTLPVWRmqepppHVP-NADADGATAPHPVEPPVA 223
Cdd:TIGR00895 139 RGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMR------FLPeSIDFLVSKRPETVRRIVN 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 224 ALLSaSPPASTVATASEASPDRPQGRRLALLWWHRAMRPGVLALACLIFCFRFGDQMAAGLiTPFLLDQGLNKADLAVLK 303
Cdd:TIGR00895 213 AIAP-QMQAEAQSALPEQKSTQGTKRSVFKALFQGKTARITVLLWLLYFMLLVGVYFLTNW-LPKLMVELGFSLSLAATG 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 304 GAVGSGTSLLGAVLGGWLMLRVGRRAALLgcGFMQAAVygLYVAAAMGLGGVPLLWLATVAEGVVGTMATVALYSLMMDS 383
Cdd:TIGR00895 291 GALFNFGGVIGSIIFGWLADRLGPRVTAL--LLLLGAV--FAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALF 366
|
250 260
....*....|....*....|....*....
gi 1082763184 384 ADPAHPGTDYTLMGSVGVSLATLGGIAGG 412
Cdd:TIGR00895 367 YPTAIRATGVGWAIGIGRLGAIIGPILAG 395
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
261-437 |
3.43e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.48 E-value: 3.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 261 RPGVLALACLIFCFRFGdQMAAGLITPFLLDQGlnkADLAVLKGAVGSG--------TSLLGAVLGGWLMLRVG-RRAAL 331
Cdd:cd17504 176 RRNVLLANITALLAGFG-MFMVFQLLPQLLQLP---TPTGFGLGITEAGllllpgalVMLIAGPLAGRLIARVGpRRVLL 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 332 LGCGFMQAAvyglYVAAAMGLGGVPLLWLATVAEGVVGTMATVALYSLMMDSADPAHPGTD---YTLMGSVGVSLATL-- 406
Cdd:cd17504 252 IGLVISAVG----LLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIAtgmNTVLRTIGSAIGPAia 327
|
170 180 190
....*....|....*....|....*....|....*....
gi 1082763184 407 --------GGIAGGMVGDHLGYATAFASGAVVSVIGLLA 437
Cdd:cd17504 328 gailttytVSITSGGVPTEGAYVLAFLIGAALALAALLL 366
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
317-439 |
4.17e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.07 E-value: 4.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 317 LGGWLMLRVGRRAALLGCGFMQAAVYGLYVAAAMGLGGVPLLWLATVAEGVVGTMATVALYSLMmdsadPAHPGTDYTLM 396
Cdd:cd17471 254 LAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLM-----PGQPGLATTLY 328
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1082763184 397 GSVGVSLATLGGIAGGMVGDHLGYATAFASGAVVSVIGLLALV 439
Cdd:cd17471 329 SNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
8-440 |
5.82e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 38.70 E-value: 5.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 8 RASIRGVTHPLRTPHLPLLAALYTAQGLPFGFFTLA--LPVLMREAGWSLTALGFLqfLAAPWVLKMLWAPVV----DHH 81
Cdd:COG2807 3 TTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGplLPEIRADLGLSATQAGLL--TTLPLLAFGLFAPLAprlaRRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 82 GKRRTWLLSMqlasCALALAMALLGFTEGSVALFVAVFAFNLLAATQDVATDGLAVRLLnAQQRGLANGIQVGAYRFGMI 161
Cdd:COG2807 81 GLERTLLLAL----LLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 162 LGGGLLLWVFAHTSWQVTFLGMALmlalltlpvwrmqeppphvpnadadgataphpvePPVAALLSASPPASTVATASEA 241
Cdd:COG2807 156 LAAGLTVPLAAALGWRGALAVWAL----------------------------------LALLALLLWLPLLRRRPAAAAA 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 242 SPDRPQGRRLallwWHramRPGVLALACLIFCFRFGDQMAAGLITPFLLDQGLNKADLAVLkGAVGSGTSLLGAVLGGWL 321
Cdd:COG2807 202 APAAASLRSL----WR---SPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLL-LSLFQLAGIPGSLLVPLL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1082763184 322 MLRVG-RRAALLGCGFMQAAVYglyvaAAMGLGGVPLLWLATVAEGVVGTMATVALYSLMMD-SADPAHPGTDYTLMGSV 399
Cdd:COG2807 274 ADRLGdRRPLLLLLGLLGLAGL-----LGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLrARTPAEAAALSGMAQSV 348
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1082763184 400 GVSLATLGGIAGGMVGDHLG-YATAFASGAVVSVIGLLALVR 440
Cdd:COG2807 349 GYLLAALGPLLVGALHDATGsWTAALLLLAALAVLMLVAGLL 390
|
|
| |
