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Conserved domains on  [gi|1083437069|gb|OGF44080|]
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phosphopyruvate hydratase [Candidatus Falkowbacteria bacterium RIFOXYB2_FULL_47_14]

Protein Classification

phosphopyruvate hydratase( domain architecture ID 11414960)

phosphopyruvate hydratase (enolase) catalyzes the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways

CATH:  3.20.20.120|3.30.390.10
EC:  4.2.1.11
Gene Ontology:  GO:0004634|GO:0000015|GO:0006096|GO:0000287
PubMed:  8994873|8605183
SCOP:  3001064|3000476

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 1-414 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 682.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069   1 MSKIKYIAAREILDSRGNPTIETKITLNSGVTAKASVPSGASTGIHEAWELRDGDKKRYGGLGVLQAVKNVNDKIFSALK 80
Cdd:COG0148     1 MSRIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069  81 GAEVSDQRKIDEAMIKLDGTKNKKKLGANAILSVSLAAARAAAFDSKRELYEYIASVfgfsGKFRLPVPAFNIFNGGKHA 160
Cdd:COG0148    81 GMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGV----NAKTLPVPMMNIINGGAHA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 161 DTNLDFQEFMIIPMKKTSFAEKVRMGAEIFHELGRVLKQAGFDTDVGNEGGYAPDIRSSIQAVELIMAAAVNAGYKPGVD 240
Cdd:COG0148   157 DNNVDIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGED 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 241 VGLGTDVGSSELYDleTKKYIFKLDQATFSKNTLIGLYYEWFRKYPIISIEDGLSEDDWEGWTELTRELGNEILLIGDDL 320
Cdd:COG0148   237 IALALDVAASEFYK--DGKYHLKGEGKELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDL 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 321 FTTNTDRLRRGLKERAANAILIKPNQVGTLTETVDCIKLAQTHNYKTMASHRSGETNDDFIADLAVAAGTDYIKSGSLAR 400
Cdd:COG0148   315 FVTNPKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSR 394

                         410
                  ....*....|....
gi 1083437069 401 SERLAKYNRLMEIE 414
Cdd:COG0148   395 SERVAKYNQLLRIE 408
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 1-414 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 682.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069   1 MSKIKYIAAREILDSRGNPTIETKITLNSGVTAKASVPSGASTGIHEAWELRDGDKKRYGGLGVLQAVKNVNDKIFSALK 80
Cdd:COG0148     1 MSRIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069  81 GAEVSDQRKIDEAMIKLDGTKNKKKLGANAILSVSLAAARAAAFDSKRELYEYIASVfgfsGKFRLPVPAFNIFNGGKHA 160
Cdd:COG0148    81 GMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGV----NAKTLPVPMMNIINGGAHA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 161 DTNLDFQEFMIIPMKKTSFAEKVRMGAEIFHELGRVLKQAGFDTDVGNEGGYAPDIRSSIQAVELIMAAAVNAGYKPGVD 240
Cdd:COG0148   157 DNNVDIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGED 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 241 VGLGTDVGSSELYDleTKKYIFKLDQATFSKNTLIGLYYEWFRKYPIISIEDGLSEDDWEGWTELTRELGNEILLIGDDL 320
Cdd:COG0148   237 IALALDVAASEFYK--DGKYHLKGEGKELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDL 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 321 FTTNTDRLRRGLKERAANAILIKPNQVGTLTETVDCIKLAQTHNYKTMASHRSGETNDDFIADLAVAAGTDYIKSGSLAR 400
Cdd:COG0148   315 FVTNPKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSR 394

                         410
                  ....*....|....
gi 1083437069 401 SERLAKYNRLMEIE 414
Cdd:COG0148   395 SERVAKYNQLLRIE 408
eno PRK00077
enolase; Provisional
 1-414 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 637.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069   1 MSKIKYIAAREILDSRGNPTIETKITLNSGVTAKASVPSGASTGIHEAWELRDGDKKRYGGLGVLQAVKNVNDKIFSALK 80
Cdd:PRK00077    1 MSKIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069  81 GAEVSDQRKIDEAMIKLDGTKNKKKLGANAILSVSLAAARAAAFDSKRELYEYIASVFGFSgkfrLPVPAFNIFNGGKHA 160
Cdd:PRK00077   81 GLDALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYLGGPNAKV----LPVPMMNIINGGAHA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 161 DTNLDFQEFMIIPMKKTSFAEKVRMGAEIFHELGRVLKQAGFDTDVGNEGGYAPDIRSSIQAVELIMAAAVNAGYKPGVD 240
Cdd:PRK00077  157 DNNVDIQEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGED 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 241 VGLGTDVGSSELYdlETKKYIFKldQATFSKNTLIGLYYEWFRKYPIISIEDGLSEDDWEGWTELTRELGNEILLIGDDL 320
Cdd:PRK00077  237 IALALDCAASEFY--KDGKYVLE--GEGLTSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDDL 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 321 FTTNTDRLRRGLKERAANAILIKPNQVGTLTETVDCIKLAQTHNYKTMASHRSGETNDDFIADLAVAAGTDYIKSGSLAR 400
Cdd:PRK00077  313 FVTNTKRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLSR 392

                         410
                  ....*....|....
gi 1083437069 401 SERLAKYNRLMEIE 414
Cdd:PRK00077  393 SERIAKYNQLLRIE 406
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
 7-414 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 616.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069   7 IAAREILDSRGNPTIETKITLNSGVTAKASVPSGASTGIHEAWELRDGDKKRYGGLGVLQAVKNVNDKIFSALKGAEVSD 86
Cdd:cd03313     2 IKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDKSRYLGKGVLKAVKNVNEIIAPALIGMDVTD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069  87 QRKIDEAMIKLDGTKNKKKLGANAILSVSLAAARAAAFDSKRELYEYIASVFgfsgKFRLPVPAFNIFNGGKHADTNLDF 166
Cdd:cd03313    82 QRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLA----AYVLPVPMFNVINGGAHAGNKLDF 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 167 QEFMIIPMKKTSFAEKVRMGAEIFHELGRVLKQAG--FDTDVGNEGGYAPDIRSSIQAVELIMAAAVNAGYKPGVDVGLG 244
Cdd:cd03313   158 QEFMIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGglLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKKIAIA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 245 TDVGSSELYDLETKKYIfKLDQATFSKNTLIGLYYEWFRKYPIISIEDGLSEDDWEGWTELTRELGNEILLIGDDLFTTN 324
Cdd:cd03313   238 LDVAASEFYDEGKYVYD-SDEGKKLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFVTN 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 325 TDRLRRGLKERAANAILIKPNQVGTLTETVDCIKLAQTHNYKTMASHRSGETNDDFIADLAVAAGTDYIKSGSLARSERL 404
Cdd:cd03313   317 PERLKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSERT 396

                         410
                  ....*....|
gi 1083437069 405 AKYNRLMEIE 414
Cdd:cd03313   397 AKYNQLLRIE 406
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
 4-414 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 578.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069   4 IKYIAAREILDSRGNPTIETKITLNSGVTAKASVPSGASTGIHEAWELRDGDKKRYGGLGVLQAVKNVNDKIFSALKGAE 83
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDKKRYLGKGVLKAVENVNEIIAPELIGMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069  84 VSDQRKIDEAMIKLDGTKNKKKLGANAILSVSLAAARAAAFDSKRELYEYIASVFGFSgkfrLPVPAFNIFNGGKHADTN 163
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNAYV----LPVPMMNIINGGAHADNN 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 164 LDFQEFMIIPMKKTSFAEKVRMGAEIFHELGRVLKQAGFDTDVGNEGGYAPDIRSSIQAVELIMAAAVNAGYKPGVDVGL 243
Cdd:TIGR01060 157 LDFQEFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGEDVAL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 244 GTDVGSSELYDLETKKYIFKLDQATFSKNTLIGLYYEWFRKYPIISIEDGLSEDDWEGWTELTRELGNEILLIGDDLFTT 323
Cdd:TIGR01060 237 ALDCAASEFYDEEDGKYVYKGENKQLTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLFVT 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 324 NTDRLRRGLKERAANAILIKPNQVGTLTETVDCIKLAQTHNYKTMASHRSGETNDDFIADLAVAAGTDYIKSGSLARSER 403
Cdd:TIGR01060 317 NTEILREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSER 396

                         410
                  ....*....|.
gi 1083437069 404 LAKYNRLMEIE 414
Cdd:TIGR01060 397 IAKYNQLLRIE 407
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
143-414 1.12e-111

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 329.44  E-value: 1.12e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 143 KFRLPVPAFNIFNGGKHADTNLDFQEFMIIPMKKTSFAEKVRMGAEIFHELGRVLKQAGFD--TDVGNEGGYAPDIRSSI 220
Cdd:pfam00113   1 SYVLPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYGQsaTNVGDEGGFAPNLQSNK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 221 QAVELIMAAAVNAGYKPgvDVGLGTDVGSSELYDLETKKYIFKLDQAT------FSKNTLIGLYYEWFRKYPIISIEDGL 294
Cdd:pfam00113  81 EALDLIVEAIEKAGYKG--KIKIAMDVASSEFYNKKDGKYDLDFKGEKsdkskkLTSAQLADLYEELVKKYPIVSIEDPF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 295 SEDDWEGWTELTRELGNEILLIGDDLFTTNTDRLRRGLKERAANAILIKPNQVGTLTETVDCIKLAQTHNYKTMASHRSG 374
Cdd:pfam00113 159 DEDDWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSG 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1083437069 375 ETNDDFIADLAVAAGTDYIKSGSLARSERLAKYNRLMEIE 414
Cdd:pfam00113 239 ETEDTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIE 278
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 1-414 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 682.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069   1 MSKIKYIAAREILDSRGNPTIETKITLNSGVTAKASVPSGASTGIHEAWELRDGDKKRYGGLGVLQAVKNVNDKIFSALK 80
Cdd:COG0148     1 MSRIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069  81 GAEVSDQRKIDEAMIKLDGTKNKKKLGANAILSVSLAAARAAAFDSKRELYEYIASVfgfsGKFRLPVPAFNIFNGGKHA 160
Cdd:COG0148    81 GMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGV----NAKTLPVPMMNIINGGAHA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 161 DTNLDFQEFMIIPMKKTSFAEKVRMGAEIFHELGRVLKQAGFDTDVGNEGGYAPDIRSSIQAVELIMAAAVNAGYKPGVD 240
Cdd:COG0148   157 DNNVDIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGED 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 241 VGLGTDVGSSELYDleTKKYIFKLDQATFSKNTLIGLYYEWFRKYPIISIEDGLSEDDWEGWTELTRELGNEILLIGDDL 320
Cdd:COG0148   237 IALALDVAASEFYK--DGKYHLKGEGKELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDL 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 321 FTTNTDRLRRGLKERAANAILIKPNQVGTLTETVDCIKLAQTHNYKTMASHRSGETNDDFIADLAVAAGTDYIKSGSLAR 400
Cdd:COG0148   315 FVTNPKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSR 394

                         410
                  ....*....|....
gi 1083437069 401 SERLAKYNRLMEIE 414
Cdd:COG0148   395 SERVAKYNQLLRIE 408
eno PRK00077
enolase; Provisional
 1-414 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 637.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069   1 MSKIKYIAAREILDSRGNPTIETKITLNSGVTAKASVPSGASTGIHEAWELRDGDKKRYGGLGVLQAVKNVNDKIFSALK 80
Cdd:PRK00077    1 MSKIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069  81 GAEVSDQRKIDEAMIKLDGTKNKKKLGANAILSVSLAAARAAAFDSKRELYEYIASVFGFSgkfrLPVPAFNIFNGGKHA 160
Cdd:PRK00077   81 GLDALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYLGGPNAKV----LPVPMMNIINGGAHA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 161 DTNLDFQEFMIIPMKKTSFAEKVRMGAEIFHELGRVLKQAGFDTDVGNEGGYAPDIRSSIQAVELIMAAAVNAGYKPGVD 240
Cdd:PRK00077  157 DNNVDIQEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGED 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 241 VGLGTDVGSSELYdlETKKYIFKldQATFSKNTLIGLYYEWFRKYPIISIEDGLSEDDWEGWTELTRELGNEILLIGDDL 320
Cdd:PRK00077  237 IALALDCAASEFY--KDGKYVLE--GEGLTSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDDL 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 321 FTTNTDRLRRGLKERAANAILIKPNQVGTLTETVDCIKLAQTHNYKTMASHRSGETNDDFIADLAVAAGTDYIKSGSLAR 400
Cdd:PRK00077  313 FVTNTKRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLSR 392

                         410
                  ....*....|....
gi 1083437069 401 SERLAKYNRLMEIE 414
Cdd:PRK00077  393 SERIAKYNQLLRIE 406
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
 7-414 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 616.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069   7 IAAREILDSRGNPTIETKITLNSGVTAKASVPSGASTGIHEAWELRDGDKKRYGGLGVLQAVKNVNDKIFSALKGAEVSD 86
Cdd:cd03313     2 IKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDKSRYLGKGVLKAVKNVNEIIAPALIGMDVTD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069  87 QRKIDEAMIKLDGTKNKKKLGANAILSVSLAAARAAAFDSKRELYEYIASVFgfsgKFRLPVPAFNIFNGGKHADTNLDF 166
Cdd:cd03313    82 QRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLA----AYVLPVPMFNVINGGAHAGNKLDF 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 167 QEFMIIPMKKTSFAEKVRMGAEIFHELGRVLKQAG--FDTDVGNEGGYAPDIRSSIQAVELIMAAAVNAGYKPGVDVGLG 244
Cdd:cd03313   158 QEFMIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGglLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKKIAIA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 245 TDVGSSELYDLETKKYIfKLDQATFSKNTLIGLYYEWFRKYPIISIEDGLSEDDWEGWTELTRELGNEILLIGDDLFTTN 324
Cdd:cd03313   238 LDVAASEFYDEGKYVYD-SDEGKKLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFVTN 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 325 TDRLRRGLKERAANAILIKPNQVGTLTETVDCIKLAQTHNYKTMASHRSGETNDDFIADLAVAAGTDYIKSGSLARSERL 404
Cdd:cd03313   317 PERLKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSERT 396

                         410
                  ....*....|
gi 1083437069 405 AKYNRLMEIE 414
Cdd:cd03313   397 AKYNQLLRIE 406
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
 4-414 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 578.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069   4 IKYIAAREILDSRGNPTIETKITLNSGVTAKASVPSGASTGIHEAWELRDGDKKRYGGLGVLQAVKNVNDKIFSALKGAE 83
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDKKRYLGKGVLKAVENVNEIIAPELIGMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069  84 VSDQRKIDEAMIKLDGTKNKKKLGANAILSVSLAAARAAAFDSKRELYEYIASVFGFSgkfrLPVPAFNIFNGGKHADTN 163
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNAYV----LPVPMMNIINGGAHADNN 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 164 LDFQEFMIIPMKKTSFAEKVRMGAEIFHELGRVLKQAGFDTDVGNEGGYAPDIRSSIQAVELIMAAAVNAGYKPGVDVGL 243
Cdd:TIGR01060 157 LDFQEFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGEDVAL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 244 GTDVGSSELYDLETKKYIFKLDQATFSKNTLIGLYYEWFRKYPIISIEDGLSEDDWEGWTELTRELGNEILLIGDDLFTT 323
Cdd:TIGR01060 237 ALDCAASEFYDEEDGKYVYKGENKQLTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLFVT 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 324 NTDRLRRGLKERAANAILIKPNQVGTLTETVDCIKLAQTHNYKTMASHRSGETNDDFIADLAVAAGTDYIKSGSLARSER 403
Cdd:TIGR01060 317 NTEILREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSER 396

                         410
                  ....*....|.
gi 1083437069 404 LAKYNRLMEIE 414
Cdd:TIGR01060 397 IAKYNQLLRIE 407
PTZ00081 PTZ00081
enolase; Provisional
 1-414 6.02e-177

enolase; Provisional


Pssm-ID: 240259 [Multi-domain]  Cd Length: 439  Bit Score: 500.73  E-value: 6.02e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069   1 MSKIKYIAAREILDSRGNPTIETKITLNSGVTaKASVPSGASTGIHEAWELRDGDKKRYGGLGVLQAVKNVNDKIFSALK 80
Cdd:PTZ00081    1 MSTIKSIKAREILDSRGNPTVEVDLTTEKGVF-RAAVPSGASTGIYEALELRDGDKSRYLGKGVLKAVENVNEIIAPALI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069  81 GAEVSDQRKIDEAMIK-LDGTKN-----KKKLGANAILSVSLAAARAAAFDSKRELYEYIASVFG-FSGKFRLPVPAFNI 153
Cdd:PTZ00081   80 GKDVTDQKKLDKLMVEqLDGTKNewgwcKSKLGANAILAVSMAVARAAAAAKGVPLYKYLAQLAGkPTDKFVLPVPCFNV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 154 FNGGKHADTNLDFQEFMIIPMKKTSFAEKVRMGAEIFHELGRVLKQA-GFD-TDVGNEGGYAPDIRSSIQAVELIMAAAV 231
Cdd:PTZ00081  160 INGGKHAGNKLAFQEFMIAPVGAPSFKEALRMGAEVYHSLKSVIKKKyGLDaTNVGDEGGFAPNIKDPEEALDLLVEAIK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 232 NAGYKPGVDVGLgtDVGSSELYDLETKKYIFKLDQATFSKNT------LIGLYYEWFRKYPIISIEDGLSEDDWEGWTEL 305
Cdd:PTZ00081  240 KAGYEGKVKICM--DVAASEFYDKEKKVYDLDFKNPNNDKSNkltgeeLVELYLDLVKKYPIVSIEDPFDQDDWEAYAKL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 306 TRELGNEILLIGDDLFTTNTDRLRRGLKERAANAILIKPNQVGTLTETVDCIKLAQTHNYKTMASHRSGETNDDFIADLA 385
Cdd:PTZ00081  318 TAAIGQKVQIVGDDLLVTNPTRIKKAIEKKACNALLLKVNQIGTVTEAIEAAKLAQKNGWGVMVSHRSGETEDTFIADLV 397

                         410       420
                  ....*....|....*....|....*....
gi 1083437069 386 VAAGTDYIKSGSLARSERLAKYNRLMEIE 414
Cdd:PTZ00081  398 VGLGTGQIKTGAPCRSERLAKYNQLLRIE 426
PLN00191 PLN00191
enolase
 1-414 3.64e-160

enolase


Pssm-ID: 215095 [Multi-domain]  Cd Length: 457  Bit Score: 458.79  E-value: 3.64e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069   1 MSKIKYIAAREILDSRGNPTIETKITLNSGVtAKASVPSGASTGIHEAWELRDGDKkRYGGLGVLQAVKNVNDKIFSALK 80
Cdd:PLN00191   25 MATITKVKARQIIDSRGNPTVEVDLHTSKGM-FRAAVPSGASTGIYEALELRDGDK-DYLGKGVLKAVKNVNEIIAPALI 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069  81 GAEVSDQRKIDEAMIKLDGTKNKKKLGANAILSVSLAAARAAAFDSKRELYEYIASVFGfSGKFRLPVPAFNIFNGGKHA 160
Cdd:PLN00191  103 GMDPTDQTQIDNFMLELDGTPNKGKLGANAILAVSLAVCKAGAAEKGVPLYKHIADLAG-NKKLVLPVPAFNVINGGSHA 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 161 DTNLDFQEFMIIPMKKTSFAEKVRMGAEIFHELGRVLKQA-GFD-TDVGNEGGYAPDIRSSIQAVELIMAAAVNAGYKPG 238
Cdd:PLN00191  182 GNKLAMQEFMILPVGASSFKEAMQMGSEVYHHLKAVIKKKyGQDaCNVGDEGGFAPNIQDNKEGLELLKEAIEKAGYTGK 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 239 VDVGLgtDVGSSELYDlETKKYI--FKLD----QATFSKNTLIGLYYEWFRKYPIISIEDGLSEDDWEGWTELTRElgNE 312
Cdd:PLN00191  262 IKIGM--DVAASEFYT-KDKKYDldFKEEnndgSNKKSGDELIDLYKEFVSDYPIVSIEDPFDQDDWEHWAKLTSL--ED 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 313 ILLIGDDLFTTNTDRLRRGLKERAANAILIKPNQVGTLTETVDCIKLAQTHNYKTMASHRSGETNDDFIADLAVAAGTDY 392
Cdd:PLN00191  337 VQIVGDDLLVTNPKRVAKAIQEKACNALLLKVNQIGTVTESIEAVKMSKAAGWGVMTSHRSGETEDSFIADLAVGLATGQ 416

                         410       420
                  ....*....|....*....|..
gi 1083437069 393 IKSGSLARSERLAKYNRLMEIE 414
Cdd:PLN00191  417 IKTGAPCRSERLAKYNQLLRIE 438
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
143-414 1.12e-111

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 329.44  E-value: 1.12e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 143 KFRLPVPAFNIFNGGKHADTNLDFQEFMIIPMKKTSFAEKVRMGAEIFHELGRVLKQAGFD--TDVGNEGGYAPDIRSSI 220
Cdd:pfam00113   1 SYVLPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYGQsaTNVGDEGGFAPNLQSNK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 221 QAVELIMAAAVNAGYKPgvDVGLGTDVGSSELYDLETKKYIFKLDQAT------FSKNTLIGLYYEWFRKYPIISIEDGL 294
Cdd:pfam00113  81 EALDLIVEAIEKAGYKG--KIKIAMDVASSEFYNKKDGKYDLDFKGEKsdkskkLTSAQLADLYEELVKKYPIVSIEDPF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 295 SEDDWEGWTELTRELGNEILLIGDDLFTTNTDRLRRGLKERAANAILIKPNQVGTLTETVDCIKLAQTHNYKTMASHRSG 374
Cdd:pfam00113 159 DEDDWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSG 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1083437069 375 ETNDDFIADLAVAAGTDYIKSGSLARSERLAKYNRLMEIE 414
Cdd:pfam00113 239 ETEDTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIE 278
Enolase_N pfam03952
Enolase, N-terminal domain;
4-116 1.16e-66

Enolase, N-terminal domain;


Pssm-ID: 461105 [Multi-domain]  Cd Length: 131  Bit Score: 208.38  E-value: 1.16e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069   4 IKYIAAREILDSRGNPTIETKITLNSGVTAKASVPSGASTGIHEAWELRDGDKKRYGGLGVLQAVKNVNDKIFSALKGAE 83
Cdd:pfam03952   1 ITKVKAREILDSRGNPTVEVEVTLEDGTFGRAAVPSGASTGEHEAVELRDGDKSRYGGKGVLKAVENVNEIIAPALIGMD 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1083437069  84 VSDQRKIDEAMIKLDGTKNKKKLGANAILSVSL 116
Cdd:pfam03952  81 ATDQRAIDRALIELDGTENKSKLGANAILGVSL 113
enolase_like cd00308
Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is ...
 282-391 3.59e-12

Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Enolase superfamily contains different enzymes, like enolases, glutarate-, fucanate- and galactonate dehydratases, o-succinylbenzoate synthase, N-acylamino acid racemase, L-alanine-DL-glutamate epimerase, mandelate racemase, muconate lactonizing enzyme and 3-methylaspartase.


Pssm-ID: 238188 [Multi-domain]  Cd Length: 229  Bit Score: 65.43  E-value: 3.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 282 FRKYPIISIEDGLSEDDWEGWTELTRELGNEILLigDDLFTTNTDRLRRgLKERAANAILIKPNQVGTLTETVDCIKLAQ 361
Cdd:cd00308   117 LEKYGLAWIEEPCAPDDLEGYAALRRRTGIPIAA--DESVTTVDDALEA-LELGAVDILQIKPTRVGGLTESRRAADLAE 193

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1083437069 362 THNyKTMASHRSGETN--DDFIADLAVAAGTD 391
Cdd:cd00308   194 AFG-IRVMVHGTLESSigTAAALHLAAALPND 224
RspA COG4948
L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane ...
 280-368 7.51e-06

L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane/envelope biogenesis, General function prediction only]; L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 443975 [Multi-domain]  Cd Length: 359  Bit Score: 47.51  E-value: 7.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 280 EWFRKYPIISIEDGLSEDDWEGWTELTRELGneILLIGDDLFTTNTDrLRRGLKERAANAILIKPNQVGTLTETVDCIKL 359
Cdd:COG4948   203 RALEDLGLEWIEQPLPAEDLEGLAELRRATP--VPIAADESLTSRAD-FRRLIEAGAVDIVNIKLSKVGGLTEALRIAAL 279


                  ....*....
gi 1083437069 360 AQTHNYKTM 368
Cdd:COG4948   280 AEAHGVPVM 288
PTZ00378 PTZ00378
hypothetical protein; Provisional
 4-414 1.98e-05

hypothetical protein; Provisional


Pssm-ID: 173571 [Multi-domain]  Cd Length: 518  Bit Score: 46.79  E-value: 1.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069   4 IKYIAAREILDSRGnptiETKITLNSGVTAKASVPSGAStgIHEAWELRDG--DKKRYGGLGVLQAVKNvndKIFSALKG 81
Cdd:PTZ00378   51 IRALVHNEVLSPAG----ETVLRFTLELLNGMEVSSGAL--LSPSHGERDGeaDATLDPAEYTTEALQN---SYFPRLLQ 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069  82 AEVSDQRKIDEAMIKLDGTKNKKKLGANAILSVSLAAARAAAFDSKRELYEYIASVFGFSGKFR-LPVPAFNI--FNGGK 158
Cdd:PTZ00378  122 LGARDQREFDSTLRAALSTSPLANVGSAVQWALSIVASLAAARCRSVPLFQYLRALFGSLTSVEtFSMPQLCItfFGPGN 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 159 HADTNLDFQEFMIIPMKKTSFAEKVRMgAEIFHELGRVLKqaGFDTDVGNEGGYAPDIRSSI-QAVELIMAAAVNAGYKP 237
Cdd:PTZ00378  202 PSTARLALKSVLFSPVMPSGTVLRERM-QKIFAAFHHFCQ--SHNSSVRSDGSLHWDGFANLtDAVKLATEALRAVQLTP 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 238 GVDVGLG-------TDVGSSELYDLETKK---------YIFKLDQATFSKNTLIGLYYEWFRKYP--IISIEDGLSEDDW 299
Cdd:PTZ00378  279 GTDVCLGlrmaastTRVPATAVADGGAWKeakddcevlYSLFPGEPDVTGDQLSEYVREQLQAVPdiVVYVEDTHCDEDT 358

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 300 EGWTELTRELGNEILLIGDDLFT-TNTDRLRRGLKERAANAILIKPNQVGTLTETVDCIKLAQTHNYKTMA-SHRSGETN 377
Cdd:PTZ00378  359 FGLQRLQAALGDSIVLSGVDVYArSEYKKVESGLRGLWTSNIVLNPCAIGTLSDVVEIVRAVGEDEGRAVTvLVQTLAGN 438

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1083437069 378 DDFIADLAVAAGTDYIKSGSLARSERLAKYNRLMEIE 414
Cdd:PTZ00378  439 AATAAHLAVAMGARFLCSGGLFSAHQCEVVSQLASRQ 475
PRK08350 PRK08350
hypothetical protein; Provisional
 66-413 9.22e-05

hypothetical protein; Provisional


Pssm-ID: 169397 [Multi-domain]  Cd Length: 341  Bit Score: 44.03  E-value: 9.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069  66 QAVKNVNDKIFSALKGAEVSDQRKIDEAMIKLDGTKNKKKLGANAILSVSLAAARAAAFDSKRELYEYIASVFgfsgKFR 145
Cdd:PRK08350   51 RAVSEVDEIIGPELIGFDASEQELIDSYLWEIDGTEDFSHIGANTALAVSVAVAKAAANSKNMPLYSYIGGTF----TTE 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 146 LPVPAFNIFNggkhaDTNLDFQEFMIIPMKKTSFAEKVRMGAEIFHELgrvlkqagfdtdvgneggyapdirssiqAVEL 225
Cdd:PRK08350  127 LPVPILEFAE-----DENFEYYVLVRDLMEITDVVDAVNKILENSKEV----------------------------SLEG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 226 IMAAAVNAGYKPGVDVGLGTDVGSselyDLETKKYIfkldqatfsknTLIGLYYEWFRKyPIisiedglseddweGWTEL 305
Cdd:PRK08350  174 LSKASEKAGDELGLEVALGIAQKR----EMETEKVL-----------NLVEDNNIAYIK-PI-------------GDEEL 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 306 TREL---GNEILLIGDDLFttntdRLRRGLKERAANAILIKPNQVGTLTETVDCIKLAQTHNYKTMASHRSGETNDDFIA 382
Cdd:PRK08350  225 FLELiagTHGVFIDGEYLF-----RTRNILDRRYYNALSIKPINLGTLTDLYNLVNDVKSERITPILAEAKYESADEALP 299

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1083437069 383 DLAVAAGTDYIksgsLARSERLAKYNRLMEI 413
Cdd:PRK08350  300 HLAVGLRCPAM----LIHKDSVEKINELNRI 326
NAAAR cd03317
N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of ...
 211-364 2.94e-04

N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building blocks for antibiotics, herbicides, and drugs. NAAAR is a member of the enolase superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.


Pssm-ID: 239433 [Multi-domain]  Cd Length: 354  Bit Score: 42.61  E-value: 2.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 211 GYAPDIRSSIQAVELimaaAVNAGY-------KPGVDVG-------------LGTDVGSSelYDLETKKYIFKLDQatfs 270
Cdd:cd03317   133 GIQDDVEQLLKQIER----YLEEGYkriklkiKPGWDVEplkavrerfpdipLMADANSA--YTLADIPLLKRLDE---- 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083437069 271 kntlIGLYYewfrkypiisIEDGLSEDDWEGWTELTRELGNEILLigdDLFTTNTDRLRRGLKERAANAILIKPNQVGTL 350
Cdd:cd03317   203 ----YGLLM----------IEQPLAADDLIDHAELQKLLKTPICL---DESIQSAEDARKAIELGACKIINIKPGRVGGL 265

                         170
                  ....*....|....
gi 1083437069 351 TETVDCIKLAQTHN 364
Cdd:cd03317   266 TEALKIHDLCQEHG 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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