|
Name |
Accession |
Description |
Interval |
E-value |
| ASS |
cd01999 |
argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle ... |
7-399 |
0e+00 |
|
argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate. In humans, a defect in the ASS gene causes citrullinemia, a genetic disease characterized by severe vomiting spells and mental retardation. ASS is a homotetrameric enzyme of about 400 amino-acid residues. An arginine residue seems to be important for the enzyme's catalytic mechanism. The sequences of ASS from various prokaryotes, archaeabacteria and eukaryotes show significant similarity.
Pssm-ID: 467503 Cd Length: 386 Bit Score: 579.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 7 RVCLAYSGGLDTSCILRWLIEE-GYEVVCFLGNVGQEEDWAAVEAKALKIGAKKMVIEDLRREFVEELCFPAIQCNAIYE 85
Cdd:cd01999 2 KVVLAYSGGLDTSVILKWLKEEyGYEVIAFTADLGQGDEEEEIEEKALKLGAVKVYVVDLREEFAEDYIFPAIKANAIYE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 86 GRYLLGTSLARPVIARAQMRVAQREGCQFVSHGATGKGNDQVRFELAFYAIQPSIKIIAPWRDPkffkRFAGRNDLLDYA 165
Cdd:cd01999 82 GRYPLGTALARPLIAKKLVEVAREEGATAVAHGCTGKGNDQVRFELAIKALAPDLKVIAPWRDW----NFLTRAEEIAYA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 166 AQTGIPVTSTKAKPWSMDANSAHCSYEAGVLEDPNHTPPADMWTMTADPLTAPNEPTDITIQFEQGVPTKLvtpQKEYTD 245
Cdd:cd01999 158 KKHGIPVPVTKKKPYSIDENLWGRSYEGGDLEDPWNEPPEDAFEWTVSPEKAPDEPEYVTIEFEKGVPVAV---NGEKLD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 246 SVELFDALNKLGYTHGVGRIDIVENRFIGLKSRGCYDSPAMTILRAAHLDLEGLVLDGQVRALRDqFVTHNWSIQLYNGY 325
Cdd:cd01999 235 PVELIEKLNEIAGRHGVGRIDIVENRLVGIKSRGVYEAPGATLLIKAHRDLEDLTLDREVLHFKD-IVSRKYAELVYNGL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084345750 326 YFSPEREFIENSLKFSQKRVNGEVRLRLYKGNPYILGRSSSTeKLYDAEEASMDSLEDFEPTDTTGFIAISSIR 399
Cdd:cd01999 314 WFDPLREALEAFIDKTQERVTGEVRLKLYKGNVIVVGRESPN-SLYSEELATYEEGDGFDQKDAEGFIKIHGLQ 386
|
|
| ArgG |
COG0137 |
Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase ... |
7-401 |
0e+00 |
|
Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase is part of the Pathway/BioSystem: Arginine biosynthesis
Pssm-ID: 439907 Cd Length: 397 Bit Score: 568.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 7 RVCLAYSGGLDTSCILRWLIEE-GYEVVCFLGNVGQEEDWAAVEAKALKIGAKKMVIEDLRREFVEELCFPAIQCNAIYE 85
Cdd:COG0137 2 KVVLAYSGGLDTSVIIPWLKEKyGYEVIAVTADVGQGEDLEAIEEKALKLGASKAYVVDAREEFVEDYVFPAIKANALYE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 86 GRYLLGTSLARPVIARAQMRVAQREGCQFVSHGATGKGNDQVRFELAFYAIQPSIKIIAPWRDPKffkrFAGRNDLLDYA 165
Cdd:COG0137 82 GKYPLGTALARPLIAKKLVEIAREEGADAVAHGCTGKGNDQVRFELAIRALAPDLKIIAPWREWD----LKSREEEIEYA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 166 AQTGIPVTSTKAKPWSMDANSAHCSYEAGVLEDPNHTPPADMWTMTADPLTAPNEPTDITIQFEQGVPTKLvtpQKEYTD 245
Cdd:COG0137 158 EEHGIPVPATKEKPYSIDENLWGRSIEGGELEDPWNEPPEDAYEWTVSPEDAPDEPEYVTITFEKGVPVAL---NGEKLS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 246 SVELFDALNKLGYTHGVGRIDIVENRFIGLKSRGCYDSPAMTILRAAHLDLEGLVLDGQVRALRDQfVTHNWSIQLYNGY 325
Cdd:COG0137 235 PVELIEELNEIGGKHGVGRIDIVENRLVGIKSRGVYEAPGATILITAHRALESLTLDRETLHFKDI-LDQKYAELVYNGL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084345750 326 YFSPEREFIENSLKFSQKRVNGEVRLRLYKGNPYILGRSSSTEkLYDAEEASMDSLEDFEPTDTTGFIAISSIRLK 401
Cdd:COG0137 314 WFSPLREALDAFIDETQKRVTGTVRLKLYKGNATVVGRKSPYS-LYDEDLATYEEDDVFDQKDAEGFIKLFGLPLR 388
|
|
| PRK00509 |
PRK00509 |
argininosuccinate synthase; Provisional |
7-405 |
0e+00 |
|
argininosuccinate synthase; Provisional
Pssm-ID: 234785 Cd Length: 399 Bit Score: 540.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 7 RVCLAYSGGLDTSCILRWLIEE-GYEVVCFLGNVGQEEDWAAVEAKALKIGAKKMVIEDLRREFVEELCFPAIQCNAIYE 85
Cdd:PRK00509 4 KVVLAYSGGLDTSVIIKWLKETyGCEVIAFTADVGQGEELEPIREKALKSGASEIYVEDLREEFVRDYVFPAIRANALYE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 86 GRYLLGTSLARPVIARAQMRVAQREGCQFVSHGATGKGNDQVRFELAFYAIQPSIKIIAPWRDPKffkrFAGRNDLLDYA 165
Cdd:PRK00509 84 GKYPLGTALARPLIAKKLVEIARKEGADAVAHGCTGKGNDQVRFELGIAALAPDLKVIAPWREWD----LKSREELIAYA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 166 AQTGIPVTSTKAKPWSMDANSAHCSYEAGVLEDPNHTPPADMWTMTADPLTAPNEPTDITIQFEQGVPTKL----VTPqk 241
Cdd:PRK00509 160 EEHGIPIPVTKKSPYSIDANLWHRSIEGGILEDPWNEPPEDVYEWTVSPEDAPDEPEYVEIEFEKGVPVAIngeaLSP-- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 242 eytdsVELFDALNKLGYTHGVGRIDIVENRFIGLKSRGCYDSPAMTILRAAHLDLEGLVLDGQVRALRDQfVTHNWSIQL 321
Cdd:PRK00509 238 -----AELIEELNELAGKHGIGRIDIVENRLVGIKSRGVYETPGGTILIKAHRALESLTLDREVAHFKDE-LEPKYAELV 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 322 YNGYYFSPEREFIENSLKFSQKRVNGEVRLRLYKGNPYILGRsSSTEKLYDAEEASMDSLEDFEPTDTTGFIAISSIRLK 401
Cdd:PRK00509 312 YNGLWFSPLREALQAFIDETQEHVTGEVRLKLYKGNAIVVGR-KSPNSLYDEDLATYEEDDVYDQKDAEGFIKLWGLPSK 390
|
....
gi 1084345750 402 KYGL 405
Cdd:PRK00509 391 IAAL 394
|
|
| Arginosuc_synth |
pfam00764 |
Arginosuccinate synthase; This family contains a PP-loop motif. |
9-402 |
0e+00 |
|
Arginosuccinate synthase; This family contains a PP-loop motif.
Pssm-ID: 279148 Cd Length: 386 Bit Score: 524.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 9 CLAYSGGLDTSCILRWLIEE-GYEVVCFLGNVGQ-EEDWAAVEAKALKIGAKKMVIEDLRREFVEELCFPAIQCNAIYEG 86
Cdd:pfam00764 1 VLAYSGGLDTSVCIPWLKEQgGYEVIAVAVDVGQgGEDIDEAREKALKLGAVKHYVIDAKEEFVEDYIFPAIQANALYED 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 87 RYLLGTSLARPVIARAQMRVAQREGCQFVSHGATGKGNDQVRFELAFYAIQPSIKIIAPWRDPKFFkrfagRNDLLDYAA 166
Cdd:pfam00764 81 RYPLGTALARPLIAKKLVEAAKKEGASAVAHGCTGKGNDQVRFEVSFRSLAPDLKVIAPVRDPNLT-----REEEIEYAE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 167 QTGIPVTSTKAKPWSMDANSAHCSYEAGVLEDPNHTPPADMWTMTADPLTAPNEPTDITIQFEQGVPTKLvtpQKEYTDS 246
Cdd:pfam00764 156 EHGIPIPVTKKSPYSIDENLWGRSIEAGILEDPWNAPPEDIYEWTKDPAKAPDEPDIVEIGFEKGVPVAL---DGEPVSP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 247 VELFDALNKLGYTHGVGRIDIVENRFIGLKSRGCYDSPAMTILRAAHLDLEGLVLDGQVRALRDQFVThNWSIQLYNGYY 326
Cdd:pfam00764 233 LELIEKLNEIAGAHGVGRIDIVEDRLVGIKSREIYEAPAATVLITAHRDLENLTLTREVLRFKRIVDQ-KWAELVYDGLW 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084345750 327 FSPEREFIENSLKFSQKRVNGEVRLRLYKGNPYILGRSSSTEkLYDAEEASMDSLEDFEPTDTTGFIAISSIRLKK 402
Cdd:pfam00764 312 FSPLKEALDAFIDKTQERVTGTVRVKLHKGSAIVLGRRSPYS-LYDEELVSYDEGDTFDQTDATGFIKIHGLQAKI 386
|
|
| argG |
TIGR00032 |
argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a ... |
7-407 |
3.08e-176 |
|
argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a very unusual clustering in the alignment, with a deep split between one cohort of E. coli, H. influenzae, and Streptomyces, and the other cohort of eukaryotes, archaea, and the rest of the eubacteria. [Amino acid biosynthesis, Glutamate family]
Pssm-ID: 199987 Cd Length: 394 Bit Score: 497.31 E-value: 3.08e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 7 RVCLAYSGGLDTSCILRWLIEEGYEVVCFLGNVGQ-EEDWAAVEAKALKIGAKKMVIEDLRREFVEELCFPAIQCNAIYE 85
Cdd:TIGR00032 1 KVVLAYSGGLDTSVCLKWLREKGYEVIAYTADVGQpEEDIDAIPEKALEYGAENHYTIDAREEFVKDYGFAAIQANAFYE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 86 GRYLLGTSLARPVIARAQMRVAQREGCQFVSHGATGKGNDQVRFELAFYAIQPSIKIIAPWRDPKFFkrfagRNDLLDYA 165
Cdd:TIGR00032 81 GTYPLSTALARPLIAKKLVEAAKKEGANAVAHGCTGKGNDQERFERSIRLLNPDLKVIAPWRDLNFT-----REEEIEYA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 166 AQTGIPVTSTKAKPWSMDANSAHCSYEAGVLEDPNHTPPADMWTMTADPLTA-PNEPTDITIQFEQGVPTKLvtpQKEYT 244
Cdd:TIGR00032 156 IQCGIPYPMSKEKPYSIDENLWGRSIEAGILEDPSTEPPEDIYMWTKFPDEAtPDEPEVVTIDFEQGVPVAL---NGVSL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 245 DSVELFDALNKLGYTHGVGRIDIVENRFIGLKSRGCYDSPAMTILRAAHLDLEGLVLDGQVRALRDqFVTHNWSIQLYNG 324
Cdd:TIGR00032 233 DPVELILEANEIAGKHGVGRIDIIENRIIGLKSREIYEAPGAALLIIAHRDLETLTLTRDVLEFKD-IVEEQYSELIYQG 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 325 YYFSPEREFIENSLKFSQKRVNGEVRLRLYKGNPYILGRsSSTEKLYDAEEASMDSLEDFEPTDTTGFIAISSIRLKKYG 404
Cdd:TIGR00032 312 LWFDPLAEALDAFIRKTQERVTGTVRVKLFKGNAIVIGR-TSPYSLYDEELVSMEKDDVFDPRDAIGFITMRGLQIKDYR 390
|
...
gi 1084345750 405 LQK 407
Cdd:TIGR00032 391 EKK 393
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ASS |
cd01999 |
argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle ... |
7-399 |
0e+00 |
|
argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate. In humans, a defect in the ASS gene causes citrullinemia, a genetic disease characterized by severe vomiting spells and mental retardation. ASS is a homotetrameric enzyme of about 400 amino-acid residues. An arginine residue seems to be important for the enzyme's catalytic mechanism. The sequences of ASS from various prokaryotes, archaeabacteria and eukaryotes show significant similarity.
Pssm-ID: 467503 Cd Length: 386 Bit Score: 579.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 7 RVCLAYSGGLDTSCILRWLIEE-GYEVVCFLGNVGQEEDWAAVEAKALKIGAKKMVIEDLRREFVEELCFPAIQCNAIYE 85
Cdd:cd01999 2 KVVLAYSGGLDTSVILKWLKEEyGYEVIAFTADLGQGDEEEEIEEKALKLGAVKVYVVDLREEFAEDYIFPAIKANAIYE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 86 GRYLLGTSLARPVIARAQMRVAQREGCQFVSHGATGKGNDQVRFELAFYAIQPSIKIIAPWRDPkffkRFAGRNDLLDYA 165
Cdd:cd01999 82 GRYPLGTALARPLIAKKLVEVAREEGATAVAHGCTGKGNDQVRFELAIKALAPDLKVIAPWRDW----NFLTRAEEIAYA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 166 AQTGIPVTSTKAKPWSMDANSAHCSYEAGVLEDPNHTPPADMWTMTADPLTAPNEPTDITIQFEQGVPTKLvtpQKEYTD 245
Cdd:cd01999 158 KKHGIPVPVTKKKPYSIDENLWGRSYEGGDLEDPWNEPPEDAFEWTVSPEKAPDEPEYVTIEFEKGVPVAV---NGEKLD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 246 SVELFDALNKLGYTHGVGRIDIVENRFIGLKSRGCYDSPAMTILRAAHLDLEGLVLDGQVRALRDqFVTHNWSIQLYNGY 325
Cdd:cd01999 235 PVELIEKLNEIAGRHGVGRIDIVENRLVGIKSRGVYEAPGATLLIKAHRDLEDLTLDREVLHFKD-IVSRKYAELVYNGL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084345750 326 YFSPEREFIENSLKFSQKRVNGEVRLRLYKGNPYILGRSSSTeKLYDAEEASMDSLEDFEPTDTTGFIAISSIR 399
Cdd:cd01999 314 WFDPLREALEAFIDKTQERVTGEVRLKLYKGNVIVVGRESPN-SLYSEELATYEEGDGFDQKDAEGFIKIHGLQ 386
|
|
| ArgG |
COG0137 |
Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase ... |
7-401 |
0e+00 |
|
Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase is part of the Pathway/BioSystem: Arginine biosynthesis
Pssm-ID: 439907 Cd Length: 397 Bit Score: 568.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 7 RVCLAYSGGLDTSCILRWLIEE-GYEVVCFLGNVGQEEDWAAVEAKALKIGAKKMVIEDLRREFVEELCFPAIQCNAIYE 85
Cdd:COG0137 2 KVVLAYSGGLDTSVIIPWLKEKyGYEVIAVTADVGQGEDLEAIEEKALKLGASKAYVVDAREEFVEDYVFPAIKANALYE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 86 GRYLLGTSLARPVIARAQMRVAQREGCQFVSHGATGKGNDQVRFELAFYAIQPSIKIIAPWRDPKffkrFAGRNDLLDYA 165
Cdd:COG0137 82 GKYPLGTALARPLIAKKLVEIAREEGADAVAHGCTGKGNDQVRFELAIRALAPDLKIIAPWREWD----LKSREEEIEYA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 166 AQTGIPVTSTKAKPWSMDANSAHCSYEAGVLEDPNHTPPADMWTMTADPLTAPNEPTDITIQFEQGVPTKLvtpQKEYTD 245
Cdd:COG0137 158 EEHGIPVPATKEKPYSIDENLWGRSIEGGELEDPWNEPPEDAYEWTVSPEDAPDEPEYVTITFEKGVPVAL---NGEKLS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 246 SVELFDALNKLGYTHGVGRIDIVENRFIGLKSRGCYDSPAMTILRAAHLDLEGLVLDGQVRALRDQfVTHNWSIQLYNGY 325
Cdd:COG0137 235 PVELIEELNEIGGKHGVGRIDIVENRLVGIKSRGVYEAPGATILITAHRALESLTLDRETLHFKDI-LDQKYAELVYNGL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084345750 326 YFSPEREFIENSLKFSQKRVNGEVRLRLYKGNPYILGRSSSTEkLYDAEEASMDSLEDFEPTDTTGFIAISSIRLK 401
Cdd:COG0137 314 WFSPLREALDAFIDETQKRVTGTVRLKLYKGNATVVGRKSPYS-LYDEDLATYEEDDVFDQKDAEGFIKLFGLPLR 388
|
|
| PRK00509 |
PRK00509 |
argininosuccinate synthase; Provisional |
7-405 |
0e+00 |
|
argininosuccinate synthase; Provisional
Pssm-ID: 234785 Cd Length: 399 Bit Score: 540.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 7 RVCLAYSGGLDTSCILRWLIEE-GYEVVCFLGNVGQEEDWAAVEAKALKIGAKKMVIEDLRREFVEELCFPAIQCNAIYE 85
Cdd:PRK00509 4 KVVLAYSGGLDTSVIIKWLKETyGCEVIAFTADVGQGEELEPIREKALKSGASEIYVEDLREEFVRDYVFPAIRANALYE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 86 GRYLLGTSLARPVIARAQMRVAQREGCQFVSHGATGKGNDQVRFELAFYAIQPSIKIIAPWRDPKffkrFAGRNDLLDYA 165
Cdd:PRK00509 84 GKYPLGTALARPLIAKKLVEIARKEGADAVAHGCTGKGNDQVRFELGIAALAPDLKVIAPWREWD----LKSREELIAYA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 166 AQTGIPVTSTKAKPWSMDANSAHCSYEAGVLEDPNHTPPADMWTMTADPLTAPNEPTDITIQFEQGVPTKL----VTPqk 241
Cdd:PRK00509 160 EEHGIPIPVTKKSPYSIDANLWHRSIEGGILEDPWNEPPEDVYEWTVSPEDAPDEPEYVEIEFEKGVPVAIngeaLSP-- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 242 eytdsVELFDALNKLGYTHGVGRIDIVENRFIGLKSRGCYDSPAMTILRAAHLDLEGLVLDGQVRALRDQfVTHNWSIQL 321
Cdd:PRK00509 238 -----AELIEELNELAGKHGIGRIDIVENRLVGIKSRGVYETPGGTILIKAHRALESLTLDREVAHFKDE-LEPKYAELV 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 322 YNGYYFSPEREFIENSLKFSQKRVNGEVRLRLYKGNPYILGRsSSTEKLYDAEEASMDSLEDFEPTDTTGFIAISSIRLK 401
Cdd:PRK00509 312 YNGLWFSPLREALQAFIDETQEHVTGEVRLKLYKGNAIVVGR-KSPNSLYDEDLATYEEDDVYDQKDAEGFIKLWGLPSK 390
|
....
gi 1084345750 402 KYGL 405
Cdd:PRK00509 391 IAAL 394
|
|
| Arginosuc_synth |
pfam00764 |
Arginosuccinate synthase; This family contains a PP-loop motif. |
9-402 |
0e+00 |
|
Arginosuccinate synthase; This family contains a PP-loop motif.
Pssm-ID: 279148 Cd Length: 386 Bit Score: 524.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 9 CLAYSGGLDTSCILRWLIEE-GYEVVCFLGNVGQ-EEDWAAVEAKALKIGAKKMVIEDLRREFVEELCFPAIQCNAIYEG 86
Cdd:pfam00764 1 VLAYSGGLDTSVCIPWLKEQgGYEVIAVAVDVGQgGEDIDEAREKALKLGAVKHYVIDAKEEFVEDYIFPAIQANALYED 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 87 RYLLGTSLARPVIARAQMRVAQREGCQFVSHGATGKGNDQVRFELAFYAIQPSIKIIAPWRDPKFFkrfagRNDLLDYAA 166
Cdd:pfam00764 81 RYPLGTALARPLIAKKLVEAAKKEGASAVAHGCTGKGNDQVRFEVSFRSLAPDLKVIAPVRDPNLT-----REEEIEYAE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 167 QTGIPVTSTKAKPWSMDANSAHCSYEAGVLEDPNHTPPADMWTMTADPLTAPNEPTDITIQFEQGVPTKLvtpQKEYTDS 246
Cdd:pfam00764 156 EHGIPIPVTKKSPYSIDENLWGRSIEAGILEDPWNAPPEDIYEWTKDPAKAPDEPDIVEIGFEKGVPVAL---DGEPVSP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 247 VELFDALNKLGYTHGVGRIDIVENRFIGLKSRGCYDSPAMTILRAAHLDLEGLVLDGQVRALRDQFVThNWSIQLYNGYY 326
Cdd:pfam00764 233 LELIEKLNEIAGAHGVGRIDIVEDRLVGIKSREIYEAPAATVLITAHRDLENLTLTREVLRFKRIVDQ-KWAELVYDGLW 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084345750 327 FSPEREFIENSLKFSQKRVNGEVRLRLYKGNPYILGRSSSTEkLYDAEEASMDSLEDFEPTDTTGFIAISSIRLKK 402
Cdd:pfam00764 312 FSPLKEALDAFIDKTQERVTGTVRVKLHKGSAIVLGRRSPYS-LYDEELVSYDEGDTFDQTDATGFIKIHGLQAKI 386
|
|
| argG |
TIGR00032 |
argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a ... |
7-407 |
3.08e-176 |
|
argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a very unusual clustering in the alignment, with a deep split between one cohort of E. coli, H. influenzae, and Streptomyces, and the other cohort of eukaryotes, archaea, and the rest of the eubacteria. [Amino acid biosynthesis, Glutamate family]
Pssm-ID: 199987 Cd Length: 394 Bit Score: 497.31 E-value: 3.08e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 7 RVCLAYSGGLDTSCILRWLIEEGYEVVCFLGNVGQ-EEDWAAVEAKALKIGAKKMVIEDLRREFVEELCFPAIQCNAIYE 85
Cdd:TIGR00032 1 KVVLAYSGGLDTSVCLKWLREKGYEVIAYTADVGQpEEDIDAIPEKALEYGAENHYTIDAREEFVKDYGFAAIQANAFYE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 86 GRYLLGTSLARPVIARAQMRVAQREGCQFVSHGATGKGNDQVRFELAFYAIQPSIKIIAPWRDPKFFkrfagRNDLLDYA 165
Cdd:TIGR00032 81 GTYPLSTALARPLIAKKLVEAAKKEGANAVAHGCTGKGNDQERFERSIRLLNPDLKVIAPWRDLNFT-----REEEIEYA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 166 AQTGIPVTSTKAKPWSMDANSAHCSYEAGVLEDPNHTPPADMWTMTADPLTA-PNEPTDITIQFEQGVPTKLvtpQKEYT 244
Cdd:TIGR00032 156 IQCGIPYPMSKEKPYSIDENLWGRSIEAGILEDPSTEPPEDIYMWTKFPDEAtPDEPEVVTIDFEQGVPVAL---NGVSL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 245 DSVELFDALNKLGYTHGVGRIDIVENRFIGLKSRGCYDSPAMTILRAAHLDLEGLVLDGQVRALRDqFVTHNWSIQLYNG 324
Cdd:TIGR00032 233 DPVELILEANEIAGKHGVGRIDIIENRIIGLKSREIYEAPGAALLIIAHRDLETLTLTRDVLEFKD-IVEEQYSELIYQG 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 325 YYFSPEREFIENSLKFSQKRVNGEVRLRLYKGNPYILGRsSSTEKLYDAEEASMDSLEDFEPTDTTGFIAISSIRLKKYG 404
Cdd:TIGR00032 312 LWFDPLAEALDAFIRKTQERVTGTVRVKLFKGNAIVIGR-TSPYSLYDEELVSMEKDDVFDPRDAIGFITMRGLQIKDYR 390
|
...
gi 1084345750 405 LQK 407
Cdd:TIGR00032 391 EKK 393
|
|
| PLN00200 |
PLN00200 |
argininosuccinate synthase; Provisional |
4-408 |
4.50e-171 |
|
argininosuccinate synthase; Provisional
Pssm-ID: 177791 Cd Length: 404 Bit Score: 484.63 E-value: 4.50e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 4 EKPRVCLAYSGGLDTSCILRWLIEE-GYEVVCFLGNVGQ-EEDWAAVEAKALKIGAKKMVIEDLRREFVEELCFPAIQCN 81
Cdd:PLN00200 4 KLNKVVLAYSGGLDTSVILKWLRENyGCEVVCFTADVGQgIEELEGLEAKAKASGAKQLVVKDLREEFVRDYIFPCLRAN 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 82 AIYEGRYLLGTSLARPVIARAQMRVAQREGCQFVSHGATGKGNDQVRFELAFYAIQPSIKIIAPWRDPKffkrFAGRNDL 161
Cdd:PLN00200 84 AIYEGKYLLGTSMARPLIAKAMVDIAKEVGADAVAHGATGKGNDQVRFELTFFALNPELKVVAPWREWD----IKGREDL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 162 LDYAAQTGIPVTSTKAKPWSMDANSAHCSYEAGVLEDPNHTPPADMWTMTADPLTAPNEPTDITIQFEQGVPTKLvtpQK 241
Cdd:PLN00200 160 IEYAKKHNIPVPVTKKSIYSRDRNLWHISYEGDILEDPANEPKEDMFMMSVSPEAAPDQPEYIEIEFEKGLPVAI---NG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 242 EYTDSVELFDALNKLGYTHGVGRIDIVENRFIGLKSRGCYDSPAMTILRAAHLDLEGLVLDGQVRALRDQFVThNWSIQL 321
Cdd:PLN00200 237 KTLSPATLLTKLNEIGGKHGIGRIDMVENRFVGMKSRGVYETPGGTILFAAHRELESLTLDRETMQVKDSLAL-KYAELV 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 322 YNGYYFSPEREFIENSLKFSQKRVNGEVRLRLYKGNPYILGRSSStEKLYDAEEASMDSLE-DFEPTDTTGFIAISSIRL 400
Cdd:PLN00200 316 YNGFWFDPERESMDAFMEKITETTTGSVRLKLYKGNVSVAGRKSP-YSLYRQDISSFEEGGgIYNQADAAGFIRLYALRL 394
|
....*...
gi 1084345750 401 KKYGLQKA 408
Cdd:PLN00200 395 RTRAMLRK 402
|
|
| PRK13820 |
PRK13820 |
argininosuccinate synthase; Provisional |
4-406 |
9.38e-127 |
|
argininosuccinate synthase; Provisional
Pssm-ID: 237521 Cd Length: 394 Bit Score: 371.57 E-value: 9.38e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 4 EKPRVCLAYSGGLDTSCILRWLIEE-GY-EVVCFLGNVGQ-EEDWAAVEAKALKIGAKKMVIeDLRREFVEELCFPAIQC 80
Cdd:PRK13820 1 MMKKVVLAYSGGLDTSVCVPLLKEKyGYdEVITVTVDVGQpEEEIKEAEEKAKKLGDKHYTI-DAKEEFAKDYIFPAIKA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 81 NAIYEGrYLLGTSLARPVIARAQMRVAQREGCQFVSHGATGKGNDQVRFELAFYAiqPSIKIIAPWRDPKFfkrfaGRND 160
Cdd:PRK13820 80 NALYEG-YPLGTALARPLIAEKIVEVAEKEGASAIAHGCTGKGNDQLRFEAVFRA--SDLEVIAPIRELNL-----TREW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 161 LLDYAAQTGIPVTSTKAKPWSMDANSAHCSYEAGVLEDPNHTPPADMWTMTADPLTAPNEPTDITIQFEQGVPTKLvtpQ 240
Cdd:PRK13820 152 EIEYAKEKGIPVPVGKEKPWSIDENLWSRSIEGGKLEDPAFEPPEEIYAWTVSPEDAPDEPEIVEIEFEEGVPVAI---N 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 241 KEYTDSVELFDALNKLGYTHGVGRIDIVENRFIGLKSRGCYDSPAMTILRAAHLDLEGLVLDGQVRALRdQFVTHNWSIQ 320
Cdd:PRK13820 229 GEKMDGVELIRKLNEIAGKHGVGRTDMMEDRVLGLKSRENYEHPAATVLLTAHKALEQLVLTREELKFK-EIVDSKWAEL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 321 LYNGYYFSPEREFIENSLKFSQKRVNGEVRLRLYKGNPYILGRSSSTeKLYDAEEASMDSlEDFEPTDTTGFIaissirl 400
Cdd:PRK13820 308 AYEGLVDEPLREDLNAFIDKTQERVTGTVTVKLYKGSARVVGRESPY-ALYSEELVSFDS-KTIDQRDAEGMA------- 378
|
....*.
gi 1084345750 401 KKYGLQ 406
Cdd:PRK13820 379 KYHGLQ 384
|
|
| PRK05370 |
PRK05370 |
argininosuccinate synthase; Validated |
7-391 |
4.42e-54 |
|
argininosuccinate synthase; Validated
Pssm-ID: 235434 Cd Length: 447 Bit Score: 185.95 E-value: 4.42e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 7 RVCLAYSGGLDTSCILRWLIEEGYEVVCFLGNVGQ--EEDWAAVEAKALKIGAKKMVIEDLRREFVEElCFPAIQCNAIY 84
Cdd:PRK05370 13 RVGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQpdEDDYDAIPRRAMEYGAENARLIDCRAQLVAE-GIAAIQCGAFH 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 85 ---EGR-YLLGTSLARPVIARAQMRVAQREGCQFVSHGATGKGNDQVRFELAFYAIQPSIKIIAPWRDPKFFKRFAGRND 160
Cdd:PRK05370 92 istGGVtYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNPELKIYKPWLDQDFIDELGGRAE 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 161 LLDYAAQTGIPVTSTKAKPWSMDANSAHCSYEAGVLEDPN---HTPPADMWTMTADPLTAPnEPTDITIQFEQGVPTKLv 237
Cdd:PRK05370 172 MSEFLIAHGFDYKMSVEKAYSTDSNMLGATHEAKDLEHLNsgiKIVNPIMGVAFWDEDVEI-KAEEVTVRFEQGRPVAL- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 238 tPQKEYTDSVELFDALNKLGYTHGVGRIDIVENRFIGLKSRGCYDSPAMTILRAAHLDLeglvldgqVRALRDQFVTHNW 317
Cdd:PRK05370 250 -NGKTFSDPVELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERL--------VTGIHNEDTIEQY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 318 SIQ-------LYNGYYFSPEREFIENSL-KFSQKRVNGEVRLRLYKGNPYILGRSSSTEKLYDAEEASMDSLED--FEPT 387
Cdd:PRK05370 321 RINgrrlgrlLYQGRWFDPQALMLRESLqRWVASAITGEVTLELRRGNDYSILNTVSPNLTYKPERLSMEKVESaaFSPD 400
|
....
gi 1084345750 388 DTTG 391
Cdd:PRK05370 401 DRIG 404
|
|
| PRK04527 |
PRK04527 |
argininosuccinate synthase; Provisional |
7-356 |
2.38e-51 |
|
argininosuccinate synthase; Provisional
Pssm-ID: 235305 Cd Length: 400 Bit Score: 177.33 E-value: 2.38e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 7 RVCLAYSGGLDTSCILRWLIEEGYEVVCFLGNVG--QEEDWAAVEAKALKIGAKKMVIEDLRREFVEELCFPAIQCNAIY 84
Cdd:PRK04527 4 DIVLAFSGGLDTSFCIPYLQERGYAVHTVFADTGgvDAEERDFIEKRAAELGAASHVTVDGGPAIWEGFVKPLVWAGEGY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 85 EGRYLLGTSlARPVIARAQMRVAQREGCQFVSHGATGKGNDQVRFELAFYAiQPSIKIIAPWRD-PKFFKRFagRNDLLD 163
Cdd:PRK04527 84 QGQYPLLVS-DRYLIVDAALKRAEELGTRIIAHGCTGMGNDQVRFDLAVKA-LGDYQIVAPIREiQKEHTQT--RAYEQK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 164 YAAQTGIPVtSTKAKPWSMDANSAHCSYEAGVLeDPNHTPPADMWTMTADPLTAPNEPTDITIQFEQGvptKLVTPQKEY 243
Cdd:PRK04527 160 YLEERGFGV-RAKQKAYTINENLLGVTMSGGEI-DRWEAPGEGARGWCAPRSAWPTEALTVTIKFVEG---EAVALDGKP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 244 TDSVELFDALNKLGYTHGVGRIDIVENRFIGLKSRGCYDSPAMTILRAAHLDLEGLVLDGQVRALRDQfVTHNWSIQLYN 323
Cdd:PRK04527 235 LPGAQILAKLNKLFAQYGVGRGVYTGDTVIGLKGRIVFEAPGLVSLLTAHRALEDAVLTKQQNRFKPD-VARKWVELVYE 313
|
330 340 350
....*....|....*....|....*....|...
gi 1084345750 324 GYYFSPEREFIENSLKFSQKRVNGEVRLRLYKG 356
Cdd:PRK04527 314 GFYHDPLKTDIEAFLKSSQAKVNGEVTLETRGG 346
|
|
| tRNA_Me_trans |
pfam03054 |
tRNA methyl transferase HUP domain; This family represents the N-terminal HUP domain in tRNA ... |
7-81 |
1.18e-03 |
|
tRNA methyl transferase HUP domain; This family represents the N-terminal HUP domain in tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs.
Pssm-ID: 460787 [Multi-domain] Cd Length: 202 Bit Score: 39.93 E-value: 1.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 7 RVCLAYSGGLDTSCILRWLIEEGYEVVC----------FLGNVGQ---EEDWAAVEAKALKIGA-----------KKMVI 62
Cdd:pfam03054 2 KVVVAMSGGVDSSVAAYLLKEQGHNVIGvfmknwdeeqSLDEEGKccsEEDLADAQRVCEQLGIplyvvnfekeyWEDVF 81
|
90 100
....*....|....*....|
gi 1084345750 63 EDLRREFVEELC-FPAIQCN 81
Cdd:pfam03054 82 EPFLDEYKNGRTpNPDVLCN 101
|
|
| QueC-like |
cd01995 |
7-cyano-7-deazaguanine synthase QueC and similar proteins; 7-cyano-7-deazaguanine synthase (EC ... |
13-74 |
3.12e-03 |
|
7-cyano-7-deazaguanine synthase QueC and similar proteins; 7-cyano-7-deazaguanine synthase (EC 6.3.4.20) is also called 7-cyano-7-carbaguanine synthase, preQ(0) synthase, or queuosine biosynthesis protein QueC. It catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)), as part of the biosynthesis pathway of queuosine (Q). Q is one of the most complex modifications occurring at the wobble position of tRNAs with GUN anticodons, and is implicated in a number of biological activities, including accuracy of decoding, virulence, and cellular differentiation. This subfamily belongs to the adenine nucleotide alpha hydrolase (AANH) superfamily that also includes other N-type ATP PPases and ATP sulfurylases. It forms an alpha/beta/alpha fold which binds to the adenosine group.
Pssm-ID: 467499 [Multi-domain] Cd Length: 208 Bit Score: 38.75 E-value: 3.12e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084345750 13 SGGLDTSCILRWLIEEGYEVVCFLGNVGQEEdwAAVEAKALKIGAKKMVIE----DLRreFVEELC 74
Cdd:cd01995 8 SGGLDSTTLLYWALKEGYEVHALTFDYGQRH--AKEELEAAKLIAKLLGIEhkviDLS--FLGELG 69
|
|
| PRK14664 |
PRK14664 |
tRNA-specific 2-thiouridylase MnmA; Provisional |
1-89 |
3.71e-03 |
|
tRNA-specific 2-thiouridylase MnmA; Provisional
Pssm-ID: 173127 [Multi-domain] Cd Length: 362 Bit Score: 39.17 E-value: 3.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084345750 1 MATEKPRVCLAYSGGLDTSCILRWLIEEGYEVVCFLGNV-GQEEDwaavEAKALkigAKKMVIE----DLRREFVEELC- 74
Cdd:PRK14664 1 MKESKKRVLVGMSGGIDSTATCLMLQEQGYEIVGVTMRVwGDEPQ----DAREL---AARMGIEhyvaDERVPFKDTIVk 73
|
90 100
....*....|....*....|....*..
gi 1084345750 75 ------------FPAIQCNAIYEGRYL 89
Cdd:PRK14664 74 nfideyrqgrtpNPCVMCNPLFKFRML 100
|
|
| |
