hypothetical protein A2Y18_03610 [Clostridiales bacterium GWD2_32_19]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| CyaB super family | cl42670 | Adenylate cyclase class IV, CYTH domain (includes archaeal enzymes of unknown function) ... |
10-172 | 1.59e-15 | ||||
Adenylate cyclase class IV, CYTH domain (includes archaeal enzymes of unknown function) [Signal transduction mechanisms, General function prediction only]; The actual alignment was detected with superfamily member COG1437: Pssm-ID: 441046 Cd Length: 173 Bit Score: 72.60 E-value: 1.59e-15
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| Name | Accession | Description | Interval | E-value | ||||
| CyaB | COG1437 | Adenylate cyclase class IV, CYTH domain (includes archaeal enzymes of unknown function) ... |
10-172 | 1.59e-15 | ||||
Adenylate cyclase class IV, CYTH domain (includes archaeal enzymes of unknown function) [Signal transduction mechanisms, General function prediction only]; Pssm-ID: 441046 Cd Length: 173 Bit Score: 72.60 E-value: 1.59e-15
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| CYTH-like_AC_IV-like | cd07890 | Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; This subgroup ... |
11-185 | 5.28e-13 | ||||
Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; This subgroup contains class IV ACs and similar proteins. AC catalyzes the conversion of ATP to 3',5'-cyclic AMP (cAMP) and PPi. cAMP is a key signaling molecule which conveys a variety of signals in different cell types. In prokaryotes, cAMP is a catabolite derepression signal which triggers the expression of metabolic pathways including the lactose operon. Six non-homologous classes of ACs have been identified (I-VI). Class IV ACs are found in this group. In bacteria, the gene encoding Class IV AC has been designated cyaB and the protein as AC2. AC-IV occurs in addition to AC-I in bacterial pathogens such as Yersinia pestis (plague disease). The role of AC-IV is unknown but it has been speculated that it may be a factor in pathogenesis, perhaps providing cAMP for a secondary internal signaling function, or for secretion and uptake into host cells, where it may disrupt normal cellular processes. This subgroup belongs to the CYTH/triphosphate tunnel metalloenzyme (TTM)-like superfamily, whose enzymes have a unique active site located within an eight-stranded beta barrel. Pssm-ID: 143628 Cd Length: 169 Bit Score: 65.37 E-value: 5.28e-13
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| cyaB | TIGR00318 | adenylyl cyclase CyaB, putative; The protein CyaB from Aeromonas hydrophila is a second ... |
9-156 | 3.04e-05 | ||||
adenylyl cyclase CyaB, putative; The protein CyaB from Aeromonas hydrophila is a second adenylyl cyclase from that species, as demonstrated by complementation in E. coli and by assay of the enzymatic properties of purified recombinant protein. It has no detectable homology to any other protein of known function, and has several unusual properties, including an optimal temperature of 65 degrees and an optimal pH of 9.5. A cluster of uncharaterized archaeal homologs may be orthologous and serve (under certain circumstances) to produce the regulatory metabolite cyclic AMP (cAMP). [Regulatory functions, Small molecule interactions] Pssm-ID: 273010 Cd Length: 174 Bit Score: 43.64 E-value: 3.04e-05
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| CYTH | pfam01928 | CYTH domain; These sequences are functionally identified as members of the adenylate cyclase ... |
11-157 | 3.54e-03 | ||||
CYTH domain; These sequences are functionally identified as members of the adenylate cyclase family, which catalyzes the conversion of ATP to 3',5'-cyclic AMP and pyrophosphate. Six distinct non-homologous classes of AC have been identified. The structure of three classes of adenylyl cyclases have been solved. Pssm-ID: 396490 Cd Length: 172 Bit Score: 37.52 E-value: 3.54e-03
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| Name | Accession | Description | Interval | E-value | ||||
| CyaB | COG1437 | Adenylate cyclase class IV, CYTH domain (includes archaeal enzymes of unknown function) ... |
10-172 | 1.59e-15 | ||||
Adenylate cyclase class IV, CYTH domain (includes archaeal enzymes of unknown function) [Signal transduction mechanisms, General function prediction only]; Pssm-ID: 441046 Cd Length: 173 Bit Score: 72.60 E-value: 1.59e-15
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| CYTH-like_AC_IV-like | cd07890 | Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; This subgroup ... |
11-185 | 5.28e-13 | ||||
Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; This subgroup contains class IV ACs and similar proteins. AC catalyzes the conversion of ATP to 3',5'-cyclic AMP (cAMP) and PPi. cAMP is a key signaling molecule which conveys a variety of signals in different cell types. In prokaryotes, cAMP is a catabolite derepression signal which triggers the expression of metabolic pathways including the lactose operon. Six non-homologous classes of ACs have been identified (I-VI). Class IV ACs are found in this group. In bacteria, the gene encoding Class IV AC has been designated cyaB and the protein as AC2. AC-IV occurs in addition to AC-I in bacterial pathogens such as Yersinia pestis (plague disease). The role of AC-IV is unknown but it has been speculated that it may be a factor in pathogenesis, perhaps providing cAMP for a secondary internal signaling function, or for secretion and uptake into host cells, where it may disrupt normal cellular processes. This subgroup belongs to the CYTH/triphosphate tunnel metalloenzyme (TTM)-like superfamily, whose enzymes have a unique active site located within an eight-stranded beta barrel. Pssm-ID: 143628 Cd Length: 169 Bit Score: 65.37 E-value: 5.28e-13
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| cyaB | TIGR00318 | adenylyl cyclase CyaB, putative; The protein CyaB from Aeromonas hydrophila is a second ... |
9-156 | 3.04e-05 | ||||
adenylyl cyclase CyaB, putative; The protein CyaB from Aeromonas hydrophila is a second adenylyl cyclase from that species, as demonstrated by complementation in E. coli and by assay of the enzymatic properties of purified recombinant protein. It has no detectable homology to any other protein of known function, and has several unusual properties, including an optimal temperature of 65 degrees and an optimal pH of 9.5. A cluster of uncharaterized archaeal homologs may be orthologous and serve (under certain circumstances) to produce the regulatory metabolite cyclic AMP (cAMP). [Regulatory functions, Small molecule interactions] Pssm-ID: 273010 Cd Length: 174 Bit Score: 43.64 E-value: 3.04e-05
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| CYTH | pfam01928 | CYTH domain; These sequences are functionally identified as members of the adenylate cyclase ... |
11-157 | 3.54e-03 | ||||
CYTH domain; These sequences are functionally identified as members of the adenylate cyclase family, which catalyzes the conversion of ATP to 3',5'-cyclic AMP and pyrophosphate. Six distinct non-homologous classes of AC have been identified. The structure of three classes of adenylyl cyclases have been solved. Pssm-ID: 396490 Cd Length: 172 Bit Score: 37.52 E-value: 3.54e-03
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| Blast search parameters | ||||
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