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Conserved domains on  [gi|1085262330|gb|OGU42621|]
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hypothetical protein A2X61_00635 [Ignavibacteria bacterium GWB2_35_12]

Protein Classification

T9SS type A sorting domain-containing protein( domain architecture ID 16073716)

T9SS type A sorting domain-containing protein may function in protein secretion; the conserved C-terminal domain functions as an outer membrane translocation signal for export of virulence factors to the cell surface; similar to Formosa agariphila endo-acting ulvan lyase involved in ulvan degradation

Gene Ontology:  GO:0005576
PubMed:  24007199

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Por_Secre_tail pfam18962
Secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, ...
 590-672 1.65e-10

Secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber have on average twenty or more copies of this C-terminal domain, associated with sorting to the outer membrane and covalent modification. This domain targets proteins to type IX secretion systems and is secreted then cleaved off by a C-terminal signal peptidease. Based on similarity to other families it is likely that this domain adopts an immunoglobulin like fold.


:

Pssm-ID: 436869 [Multi-domain]  Cd Length: 75  Bit Score: 57.24  E-value: 1.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085262330 590 VYPNPVSERVYIAFLQQVTTRFTLGIYDMSGKLIRIIgagrippgRYLYSWDLHDINWVKVSTGIYFIRFSTNEGTTVSK 669
Cdd:pfam18962   1 IYPNPAKDVLNISLKNSNSSNLNISIYDILGKLVKSN--------SKTNGNNTKTIDVSNLSSGIYFVKINSGNGSTTKK 72


                  ...
gi 1085262330 670 VFV 672
Cdd:pfam18962  73 LII 75
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
476-560 8.04e-07

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.31  E-value: 8.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085262330 476 APPSNLMIVSSTispdSEYIDMKWERSADSDIIGYNIYRTDSINTKFEKLNSVpiNDTNFTDYKPKYGRNI-YMVRAVKN 554
Cdd:COG3401   234 SAPTGLTATADT----PGSVTLSWDPVTESDATGYRVYRSNSGDGPFTKVATV--TTTSYTDTGLTNGTTYyYRVTAVDA 307


                  ....*.
gi 1085262330 555 QHSASG 560
Cdd:COG3401   308 AGNESA 313
 
Name Accession Description Interval E-value
Por_Secre_tail pfam18962
Secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, ...
 590-672 1.65e-10

Secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber have on average twenty or more copies of this C-terminal domain, associated with sorting to the outer membrane and covalent modification. This domain targets proteins to type IX secretion systems and is secreted then cleaved off by a C-terminal signal peptidease. Based on similarity to other families it is likely that this domain adopts an immunoglobulin like fold.


Pssm-ID: 436869 [Multi-domain]  Cd Length: 75  Bit Score: 57.24  E-value: 1.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085262330 590 VYPNPVSERVYIAFLQQVTTRFTLGIYDMSGKLIRIIgagrippgRYLYSWDLHDINWVKVSTGIYFIRFSTNEGTTVSK 669
Cdd:pfam18962   1 IYPNPAKDVLNISLKNSNSSNLNISIYDILGKLVKSN--------SKTNGNNTKTIDVSNLSSGIYFVKINSGNGSTTKK 72


                  ...
gi 1085262330 670 VFV 672
Cdd:pfam18962  73 LII 75
Por_Secre_tail TIGR04183
Por secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, ...
 590-672 2.54e-07

Por secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.


Pssm-ID: 275036 [Multi-domain]  Cd Length: 72  Bit Score: 48.17  E-value: 2.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085262330 590 VYPNPVSERVYIAFLQQVTTrFTLGIYDMSGKLIRIIGAGrippgrylyswDLHDINWVKVSTGIYFIRFSTNEGTTVSK 669
Cdd:TIGR04183   1 IYPNPAKGTLIIILLSSSGK-VKVEIYDLSGKLVKKTTLN-----------NSNSIDLSNLSSGVYIVKITTGNGTITKK 68


                  ...
gi 1085262330 670 VFV 672
Cdd:TIGR04183  69 IIK 71
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
476-560 8.04e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.31  E-value: 8.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085262330 476 APPSNLMIVSSTispdSEYIDMKWERSADSDIIGYNIYRTDSINTKFEKLNSVpiNDTNFTDYKPKYGRNI-YMVRAVKN 554
Cdd:COG3401   234 SAPTGLTATADT----PGSVTLSWDPVTESDATGYRVYRSNSGDGPFTKVATV--TTTSYTDTGLTNGTTYyYRVTAVDA 307


                  ....*.
gi 1085262330 555 QHSASG 560
Cdd:COG3401   308 AGNESA 313
FlgD COG1843
Flagellar hook-capping protein FlgD [Cell motility];
582-668 6.05e-04

Flagellar hook-capping protein FlgD [Cell motility];


Pssm-ID: 441448 [Multi-domain]  Cd Length: 223  Bit Score: 41.91  E-value: 6.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085262330 582 MMTAPVFNVYPNPVSERVYiafLQQVTTRFTLGIYDMSGKLIRIIGAGRIPPGRYLYSWDLHDINWVKVSTGIYFIRFS- 660
Cdd:COG1843    99 LVEGNTISLDGGSASGGFE---LPSAADSVTVTITDANGNVVRTIDLGAQSAGVHTFTWDGTDDDGNALPDGTYTFSVEa 175


                  ....*...
gi 1085262330 661 TNEGTTVS 668
Cdd:COG1843   176 TDDGEPVT 183
T9SSA_dep_M36 NF038113
T9SS-dependent M36 family metallopeptidase; Members of this family have an M36 family ...
 588-672 2.86e-03

T9SS-dependent M36 family metallopeptidase; Members of this family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal T9SS type A sorting domain (see TIGR04131).


Pssm-ID: 468356 [Multi-domain]  Cd Length: 868  Bit Score: 40.79  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085262330 588 FNVYPNPVSERVYIAFLQQVTTRFTLGIYDMSGKLIriigagrippgrYLYSWDL---HDINWVKVSTGIYFIRFSTNEG 664
Cdd:NF038113  792 FIIYPNPAKGEIFISFSNKDSGEVKVKVYDINGRLV------------LSDKVELtntKTINTSGLQSGIYIVKIEGGSK 859


                  ....*...
gi 1085262330 665 TTVSKVFV 672
Cdd:NF038113  860 SYTEKLIV 867
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 477-536 7.79e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 36.32  E-value: 7.79e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1085262330 477 PPSNLMIvsSTISPDSeyIDMKWERSAD--SDIIGYNIYRTDSINTKFEKLNSVPINDTNFT 536
Cdd:cd00063     3 PPTNLRV--TDVTSTS--VTLSWTPPEDdgGPITGYVVEYREKGSGDWKEVEVTPGSETSYT 60
 
Name Accession Description Interval E-value
Por_Secre_tail pfam18962
Secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, ...
 590-672 1.65e-10

Secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber have on average twenty or more copies of this C-terminal domain, associated with sorting to the outer membrane and covalent modification. This domain targets proteins to type IX secretion systems and is secreted then cleaved off by a C-terminal signal peptidease. Based on similarity to other families it is likely that this domain adopts an immunoglobulin like fold.


Pssm-ID: 436869 [Multi-domain]  Cd Length: 75  Bit Score: 57.24  E-value: 1.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085262330 590 VYPNPVSERVYIAFLQQVTTRFTLGIYDMSGKLIRIIgagrippgRYLYSWDLHDINWVKVSTGIYFIRFSTNEGTTVSK 669
Cdd:pfam18962   1 IYPNPAKDVLNISLKNSNSSNLNISIYDILGKLVKSN--------SKTNGNNTKTIDVSNLSSGIYFVKINSGNGSTTKK 72


                  ...
gi 1085262330 670 VFV 672
Cdd:pfam18962  73 LII 75
Por_Secre_tail TIGR04183
Por secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, ...
 590-672 2.54e-07

Por secretion system C-terminal sorting domain; Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.


Pssm-ID: 275036 [Multi-domain]  Cd Length: 72  Bit Score: 48.17  E-value: 2.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085262330 590 VYPNPVSERVYIAFLQQVTTrFTLGIYDMSGKLIRIIGAGrippgrylyswDLHDINWVKVSTGIYFIRFSTNEGTTVSK 669
Cdd:TIGR04183   1 IYPNPAKGTLIIILLSSSGK-VKVEIYDLSGKLVKKTTLN-----------NSNSIDLSNLSSGVYIVKITTGNGTITKK 68


                  ...
gi 1085262330 670 VFV 672
Cdd:TIGR04183  69 IIK 71
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
476-560 8.04e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.31  E-value: 8.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085262330 476 APPSNLMIVSSTispdSEYIDMKWERSADSDIIGYNIYRTDSINTKFEKLNSVpiNDTNFTDYKPKYGRNI-YMVRAVKN 554
Cdd:COG3401   234 SAPTGLTATADT----PGSVTLSWDPVTESDATGYRVYRSNSGDGPFTKVATV--TTTSYTDTGLTNGTTYyYRVTAVDA 307


                  ....*.
gi 1085262330 555 QHSASG 560
Cdd:COG3401   308 AGNESA 313
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
476-552 2.73e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.39  E-value: 2.73e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1085262330 476 APPSNLmivsSTISPDSEYIDMKWERSADSDIIGYNIYRTDSINTKFEKLNSVpINDTNFTDYKPKYGRN-IYMVRAV 552
Cdd:COG3401   328 AAPSGL----TATAVGSSSITLSWTASSDADVTGYNVYRSTSGGGTYTKIAET-VTTTSYTDTGLTPGTTyYYKVTAV 400
FLgD_tudor pfam13861
FlgD Tudor-like domain; This domain has a tudor domain-like beta barrel fold. It is found in ...
 612-668 3.12e-04

FlgD Tudor-like domain; This domain has a tudor domain-like beta barrel fold. It is found in the FlgD protein the flagellar hook capping protein. The structure for this domain shows that it contains a nested Ig-like domain within it. However in some firmicute proteins this inserted domain is absent such as Q67K21.


Pssm-ID: 433533  Cd Length: 136  Bit Score: 41.43  E-value: 3.12e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1085262330 612 TLGIYDMSGKLIRIIGAGRIPPGRYLYSWDLHDINWVKVSTGIYFIRFS-TNEGTTVS 668
Cdd:pfam13861  43 TVTIYDSSGQVVRTIDLGAQAAGNVSFTWDGKDSDGNQLPDGTYTFSVTaTADGTSVA 100
FlgD COG1843
Flagellar hook-capping protein FlgD [Cell motility];
582-668 6.05e-04

Flagellar hook-capping protein FlgD [Cell motility];


Pssm-ID: 441448 [Multi-domain]  Cd Length: 223  Bit Score: 41.91  E-value: 6.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085262330 582 MMTAPVFNVYPNPVSERVYiafLQQVTTRFTLGIYDMSGKLIRIIGAGRIPPGRYLYSWDLHDINWVKVSTGIYFIRFS- 660
Cdd:COG1843    99 LVEGNTISLDGGSASGGFE---LPSAADSVTVTITDANGNVVRTIDLGAQSAGVHTFTWDGTDDDGNALPDGTYTFSVEa 175


                  ....*...
gi 1085262330 661 TNEGTTVS 668
Cdd:COG1843   176 TDDGEPVT 183
T9SSA_dep_M36 NF038113
T9SS-dependent M36 family metallopeptidase; Members of this family have an M36 family ...
 588-672 2.86e-03

T9SS-dependent M36 family metallopeptidase; Members of this family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal T9SS type A sorting domain (see TIGR04131).


Pssm-ID: 468356 [Multi-domain]  Cd Length: 868  Bit Score: 40.79  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085262330 588 FNVYPNPVSERVYIAFLQQVTTRFTLGIYDMSGKLIriigagrippgrYLYSWDL---HDINWVKVSTGIYFIRFSTNEG 664
Cdd:NF038113  792 FIIYPNPAKGEIFISFSNKDSGEVKVKVYDINGRLV------------LSDKVELtntKTINTSGLQSGIYIVKIEGGSK 859


                  ....*...
gi 1085262330 665 TTVSKVFV 672
Cdd:NF038113  860 SYTEKLIV 867
FlgD_ig pfam13860
FlgD Ig-like domain; This domains has an immunoglobulin like beta sandwich fold. It is found ...
 612-655 4.67e-03

FlgD Ig-like domain; This domains has an immunoglobulin like beta sandwich fold. It is found in the FlgD protein the flagellar hook capping protein. THe structure for this domain shows that it is inserted within a TUDOR like beta barrel domain.


Pssm-ID: 433532 [Multi-domain]  Cd Length: 78  Bit Score: 36.56  E-value: 4.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1085262330 612 TLGIYDMSGKLIRIIGAGRIPPGRYLYSWDLHDINWVKVSTGIY 655
Cdd:pfam13860  26 TVTIYDAAGQLVRTIDLGAQSAGDVSFTWDGTDDDGNKLADGTY 69
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 477-536 7.79e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 36.32  E-value: 7.79e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1085262330 477 PPSNLMIvsSTISPDSeyIDMKWERSAD--SDIIGYNIYRTDSINTKFEKLNSVPINDTNFT 536
Cdd:cd00063     3 PPTNLRV--TDVTSTS--VTLSWTPPEDdgGPITGYVVEYREKGSGDWKEVEVTPGSETSYT 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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