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Conserved domains on  [gi|1088125409|gb|OGZ88393|]
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MAG: hypothetical protein A2463_00550 [Candidatus Staskawiczbacteria bacterium RIFOXYC2_FULL_32_10]

Protein Classification

glycosyltransferase family A protein( domain architecture ID 10091567)

glycosyltransferase family A protein is a glycosyltransferase with a common GT-A type structural fold

CATH:  3.90.550.10
CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  9445404|12691742|10521532|12200473|10508766
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 2-49 1.88e-05

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


:

Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 43.65  E-value: 1.88e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1088125409   2 HFARNTASKIAEGEILYFTDDDMKADGGLLEEIIKVFDKEKDIGAVTG 49
Cdd:cd00761    66 AAARNAGLKAARGEYILFLDADDLLLPDWLERLVAELLADPEADAVGG 113
 
Name Accession Description Interval E-value
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 2-49 1.88e-05

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 43.65  E-value: 1.88e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1088125409   2 HFARNTASKIAEGEILYFTDDDMKADGGLLEEIIKVFDKEKDIGAVTG 49
Cdd:cd00761    66 AAARNAGLKAARGEYILFLDADDLLLPDWLERLVAELLADPEADAVGG 113
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 4-89 1.38e-04

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 41.23  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088125409   4 ARNTASKIAEGEILYFTDDDMKADGGLLEEIIKVFDKEKDIGAVtGLILPIFEVNPPKWILENCYNSILSLTEPTREKKE 83
Cdd:pfam00535  69 ARNAGLRAATGDYIAFLDADDEVPPDWLEKLVEALEEDGADVVV-GSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGL 147


                  ....*.
gi 1088125409  84 IISYES 89
Cdd:pfam00535 148 NLPFLI 153
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
3-60 9.26e-03

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 36.70  E-value: 9.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1088125409   3 FARNTASKIAEGEILYFTDDDMKADGGLLEEIIKVFDKEKDIGAVTGLILPIFEVNPP 60
Cdd:NF038302   76 FARQRAIQEAKGELIGFLDDDNLPAPNWVAAAYAFGQEHPQAGAYGSQIHGDFEVEPP 133
 
Name Accession Description Interval E-value
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 2-49 1.88e-05

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 43.65  E-value: 1.88e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1088125409   2 HFARNTASKIAEGEILYFTDDDMKADGGLLEEIIKVFDKEKDIGAVTG 49
Cdd:cd00761    66 AAARNAGLKAARGEYILFLDADDLLLPDWLERLVAELLADPEADAVGG 113
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 4-89 1.38e-04

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 41.23  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088125409   4 ARNTASKIAEGEILYFTDDDMKADGGLLEEIIKVFDKEKDIGAVtGLILPIFEVNPPKWILENCYNSILSLTEPTREKKE 83
Cdd:pfam00535  69 ARNAGLRAATGDYIAFLDADDEVPPDWLEKLVEALEEDGADVVV-GSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGL 147


                  ....*.
gi 1088125409  84 IISYES 89
Cdd:pfam00535 148 NLPFLI 153
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
3-60 9.26e-03

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 36.70  E-value: 9.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1088125409   3 FARNTASKIAEGEILYFTDDDMKADGGLLEEIIKVFDKEKDIGAVTGLILPIFEVNPP 60
Cdd:NF038302   76 FARQRAIQEAKGELIGFLDDDNLPAPNWVAAAYAFGQEHPQAGAYGSQIHGDFEVEPP 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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