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Conserved domains on  [gi|1088185074|gb|OHA44699|]
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MAG: hypothetical protein A3H13_03120 [Candidatus Taylorbacteria bacterium RIFCSPLOWO2_12_FULL_48_11]

Protein Classification

triose-phosphate isomerase family protein( domain architecture ID 10785057)

triose-phosphate isomerase (TIM or TPI) family protein such as TIM, a glycolytic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate

CATH:  3.20.20.70
EC:  5.3.1.-
Gene Ontology:  GO:0005975|GO:0004807|GO:0006094|GO:0006096
PubMed:  12206759|11257493
SCOP:  4003038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 5-245 2.42e-86

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 256.91  E-value: 2.42e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074   5 KKLIVANWKMNpGTAAEARSLFLASRRAAAEARRLSVVVCPPFPFLSLFSRLANGV-ISLGSQDACWRNGGPYTGEVSPE 83
Cdd:COG0149     3 KPLIAGNWKMN-GTLAEAKALLAALAAALADLADVEVVVCPPFTYLAAVAEALAGSpIALGAQNVHWEDSGAYTGEISAA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  84 ILKDIGVTISIIGHSERRAR-GETDDIVSRKAQAVVREGITALVCVGERTRD-ENGDFFATLREQIKASFSKVQRRFLSD 161
Cdd:COG0149    82 MLKDLGCRYVIVGHSERRQYfGETDELVNKKVKAALAAGLTPILCVGETLEErEAGKTEEVVARQLKAALAGLSAEQAAN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074 162 IIIAYEPLWAIGRNwrDAATPEAVREAAIFIRKVMADIFGDAGAQAL-VLYGGSVGPENAQALLRDGDIAGFLVGHESLE 240
Cdd:COG0149   162 VVIAYEPVWAIGTG--KTATPEQAQEVHAFIRALLAELYGAEVAEAVrILYGGSVKPGNAAELFAQPDIDGALVGGASLD 239


                  ....*
gi 1088185074 241 PDAFA 245
Cdd:COG0149   240 AEDFL 244
 
Name Accession Description Interval E-value
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 5-245 2.42e-86

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 256.91  E-value: 2.42e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074   5 KKLIVANWKMNpGTAAEARSLFLASRRAAAEARRLSVVVCPPFPFLSLFSRLANGV-ISLGSQDACWRNGGPYTGEVSPE 83
Cdd:COG0149     3 KPLIAGNWKMN-GTLAEAKALLAALAAALADLADVEVVVCPPFTYLAAVAEALAGSpIALGAQNVHWEDSGAYTGEISAA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  84 ILKDIGVTISIIGHSERRAR-GETDDIVSRKAQAVVREGITALVCVGERTRD-ENGDFFATLREQIKASFSKVQRRFLSD 161
Cdd:COG0149    82 MLKDLGCRYVIVGHSERRQYfGETDELVNKKVKAALAAGLTPILCVGETLEErEAGKTEEVVARQLKAALAGLSAEQAAN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074 162 IIIAYEPLWAIGRNwrDAATPEAVREAAIFIRKVMADIFGDAGAQAL-VLYGGSVGPENAQALLRDGDIAGFLVGHESLE 240
Cdd:COG0149   162 VVIAYEPVWAIGTG--KTATPEQAQEVHAFIRALLAELYGAEVAEAVrILYGGSVKPGNAAELFAQPDIDGALVGGASLD 239


                  ....*
gi 1088185074 241 PDAFA 245
Cdd:COG0149   240 AEDFL 244
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 6-245 4.70e-81

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 243.21  E-value: 4.70e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074   6 KLIVANWKMNpGTAAEARSLFLASRRAAAEARRLSVVVCPPFPFLSLFSR-LANGVISLGSQDACWRNGGPYTGEVSPEI 84
Cdd:cd00311     1 PLVAGNWKMN-GTLAEALELAKALNAVLKDESGVEVVVAPPFTYLAAVAEaLEGSKIKVGAQNVSPEDSGAFTGEISAEM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  85 LKDIGVTISIIGHSERRA-RGETDDIVSRKAQAVVREGITALVCVGE-RTRDENGDFFATLREQIKASFSKVQRrfLSDI 162
Cdd:cd00311    80 LKDAGAKYVIIGHSERRQyFGETDEDVAKKVKAALEAGLTPILCVGEtLEEREAGKTEEVVAAQLAAVLAGVED--LAPV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074 163 IIAYEPLWAIGRNwrDAATPEAVREAAIFIRKVMADIFGDAGAQALVLYGGSVGPENAQALLRDGDIAGFLVGHESLEPD 242
Cdd:cd00311   158 VIAYEPVWAIGTG--KTASPEQAQEVHAFIRKLLAELYGEVAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLKAE 235


                  ...
gi 1088185074 243 AFA 245
Cdd:cd00311   236 SFL 238
tpiA PRK00042
triosephosphate isomerase; Provisional
 5-252 6.77e-80

triosephosphate isomerase; Provisional


Pssm-ID: 234589  Cd Length: 250  Bit Score: 240.41  E-value: 6.77e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074   5 KKLIVANWKMNpGTAAEARSLFLASRRAAAEARRLSVVVCPPFPFLSLFSRLANG-VISLGSQDACWRNGGPYTGEVSPE 83
Cdd:PRK00042    2 KPIIAGNWKMN-KTLAEAKALVEELKAALPDADGVEVAVAPPFTALASVKEALKGsNIKLGAQNVHPEDSGAFTGEISAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  84 ILKDIGVTISIIGHSERRAR-GETDDIVSRKAQAVVREGITALVCVGErTRD--ENGDFFATLREQIKASFSKVQRRFLS 160
Cdd:PRK00042   81 MLKDLGVKYVIIGHSERRQYfGETDELVNKKVKAALKAGLTPILCVGE-TLEerEAGKTEEVVARQLEAALAGLSAEQFA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074 161 DIIIAYEPLWAIGRNwrDAATPEAVREAAIFIRKVMADIFGDAGAQALVLYGGSVGPENAQALLRDGDIAGFLVGHESLE 240
Cdd:PRK00042  160 NLVIAYEPVWAIGTG--KTATPEQAQEVHAFIRAVLAELYGEVAEKVRILYGGSVKPDNAAELMAQPDIDGALVGGASLK 237

                         250
                  ....*....|..
gi 1088185074 241 PDAFAwltQIAN 252
Cdd:PRK00042  238 AEDFL---AIVK 246
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 6-245 2.79e-76

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 231.25  E-value: 2.79e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074   6 KLIVANWKMNpGTAAEARSLFLASRRAAAEARRLSVVVCPPFPFLSLFSRLANGVISLGSQDACWRNGGPYTGEVSPEIL 85
Cdd:pfam00121   1 PIIAGNWKMN-GTLAEAAELLAELAEALADESGVEVVVAPPFTYLSAVAELLGSNIKVGAQNVDPEESGAFTGEISAEML 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  86 KDIGVTISIIGHSERRAR-GETDDIVSRKAQAVVREGITALVCVGE-RTRDENGDFFATLREQIKASFSKVQrRFLSDII 163
Cdd:pfam00121  80 KDLGVSYVIIGHSERRQYfGETDEDVAKKVKAALKAGLTPILCVGEtLEEREAGKTEEVVARQLDAALAGLG-AEQKNLV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074 164 IAYEPLWAIGRNwrDAATPEAVREAAIFIRKVMADIFGDAGAQALVLYGGSVGPENAQALLRDGDIAGFLVGHESLEPDA 243
Cdd:pfam00121 159 IAYEPVWAIGTG--KTATPEQAQEVHAFIRAVLAELYKEVAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASLKAED 236


                  ..
gi 1088185074 244 FA 245
Cdd:pfam00121 237 FL 238
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 7-242 9.77e-22

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 89.48  E-value: 9.77e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074   7 LIVANWKMNPGTAAEARSLFLASRRAAAEARRLSVVVCPPFPFLSLFSRLANgvISLGSQDACWRNGGPYTGEVSPEILK 86
Cdd:TIGR00419   1 LVIGNWKTYNESRGMRALEVAKIAEEVASEAGVAVAVAPPFVDLPMIKREVE--IPVYAQHVDAVLSGAHTGEISAEMLK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  87 DIGVTISIIGHSERRARgETDdiVSRKAQAVVREGITALVCVGertrdengdffATLREQIKASFSKVqrrflsdiIIAY 166
Cdd:TIGR00419  79 DIGAKGTLINHSERRMK-LAD--IEKKIARLKELGLTSVVCTN-----------NVLTTAAAAALEPD--------VVAV 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1088185074 167 EPLWAIGRNwrDAATPEAVREAAIFIRkVMADIfgdaGAQALVLYGGSVGPENAQALLRDGDIAGFLVGHESLEPD 242
Cdd:TIGR00419 137 EPPELIGTG--IPVSPAQPEVVHGSVR-AVKEV----NESVRVLCGAGISTGEDAELAAQLGAEGVLLASGSLKAD 205
 
Name Accession Description Interval E-value
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 5-245 2.42e-86

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 256.91  E-value: 2.42e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074   5 KKLIVANWKMNpGTAAEARSLFLASRRAAAEARRLSVVVCPPFPFLSLFSRLANGV-ISLGSQDACWRNGGPYTGEVSPE 83
Cdd:COG0149     3 KPLIAGNWKMN-GTLAEAKALLAALAAALADLADVEVVVCPPFTYLAAVAEALAGSpIALGAQNVHWEDSGAYTGEISAA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  84 ILKDIGVTISIIGHSERRAR-GETDDIVSRKAQAVVREGITALVCVGERTRD-ENGDFFATLREQIKASFSKVQRRFLSD 161
Cdd:COG0149    82 MLKDLGCRYVIVGHSERRQYfGETDELVNKKVKAALAAGLTPILCVGETLEErEAGKTEEVVARQLKAALAGLSAEQAAN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074 162 IIIAYEPLWAIGRNwrDAATPEAVREAAIFIRKVMADIFGDAGAQAL-VLYGGSVGPENAQALLRDGDIAGFLVGHESLE 240
Cdd:COG0149   162 VVIAYEPVWAIGTG--KTATPEQAQEVHAFIRALLAELYGAEVAEAVrILYGGSVKPGNAAELFAQPDIDGALVGGASLD 239


                  ....*
gi 1088185074 241 PDAFA 245
Cdd:COG0149   240 AEDFL 244
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 6-245 4.70e-81

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 243.21  E-value: 4.70e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074   6 KLIVANWKMNpGTAAEARSLFLASRRAAAEARRLSVVVCPPFPFLSLFSR-LANGVISLGSQDACWRNGGPYTGEVSPEI 84
Cdd:cd00311     1 PLVAGNWKMN-GTLAEALELAKALNAVLKDESGVEVVVAPPFTYLAAVAEaLEGSKIKVGAQNVSPEDSGAFTGEISAEM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  85 LKDIGVTISIIGHSERRA-RGETDDIVSRKAQAVVREGITALVCVGE-RTRDENGDFFATLREQIKASFSKVQRrfLSDI 162
Cdd:cd00311    80 LKDAGAKYVIIGHSERRQyFGETDEDVAKKVKAALEAGLTPILCVGEtLEEREAGKTEEVVAAQLAAVLAGVED--LAPV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074 163 IIAYEPLWAIGRNwrDAATPEAVREAAIFIRKVMADIFGDAGAQALVLYGGSVGPENAQALLRDGDIAGFLVGHESLEPD 242
Cdd:cd00311   158 VIAYEPVWAIGTG--KTASPEQAQEVHAFIRKLLAELYGEVAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLKAE 235


                  ...
gi 1088185074 243 AFA 245
Cdd:cd00311   236 SFL 238
tpiA PRK00042
triosephosphate isomerase; Provisional
 5-252 6.77e-80

triosephosphate isomerase; Provisional


Pssm-ID: 234589  Cd Length: 250  Bit Score: 240.41  E-value: 6.77e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074   5 KKLIVANWKMNpGTAAEARSLFLASRRAAAEARRLSVVVCPPFPFLSLFSRLANG-VISLGSQDACWRNGGPYTGEVSPE 83
Cdd:PRK00042    2 KPIIAGNWKMN-KTLAEAKALVEELKAALPDADGVEVAVAPPFTALASVKEALKGsNIKLGAQNVHPEDSGAFTGEISAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  84 ILKDIGVTISIIGHSERRAR-GETDDIVSRKAQAVVREGITALVCVGErTRD--ENGDFFATLREQIKASFSKVQRRFLS 160
Cdd:PRK00042   81 MLKDLGVKYVIIGHSERRQYfGETDELVNKKVKAALKAGLTPILCVGE-TLEerEAGKTEEVVARQLEAALAGLSAEQFA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074 161 DIIIAYEPLWAIGRNwrDAATPEAVREAAIFIRKVMADIFGDAGAQALVLYGGSVGPENAQALLRDGDIAGFLVGHESLE 240
Cdd:PRK00042  160 NLVIAYEPVWAIGTG--KTATPEQAQEVHAFIRAVLAELYGEVAEKVRILYGGSVKPDNAAELMAQPDIDGALVGGASLK 237

                         250
                  ....*....|..
gi 1088185074 241 PDAFAwltQIAN 252
Cdd:PRK00042  238 AEDFL---AIVK 246
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 6-245 2.79e-76

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 231.25  E-value: 2.79e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074   6 KLIVANWKMNpGTAAEARSLFLASRRAAAEARRLSVVVCPPFPFLSLFSRLANGVISLGSQDACWRNGGPYTGEVSPEIL 85
Cdd:pfam00121   1 PIIAGNWKMN-GTLAEAAELLAELAEALADESGVEVVVAPPFTYLSAVAELLGSNIKVGAQNVDPEESGAFTGEISAEML 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  86 KDIGVTISIIGHSERRAR-GETDDIVSRKAQAVVREGITALVCVGE-RTRDENGDFFATLREQIKASFSKVQrRFLSDII 163
Cdd:pfam00121  80 KDLGVSYVIIGHSERRQYfGETDEDVAKKVKAALKAGLTPILCVGEtLEEREAGKTEEVVARQLDAALAGLG-AEQKNLV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074 164 IAYEPLWAIGRNwrDAATPEAVREAAIFIRKVMADIFGDAGAQALVLYGGSVGPENAQALLRDGDIAGFLVGHESLEPDA 243
Cdd:pfam00121 159 IAYEPVWAIGTG--KTATPEQAQEVHAFIRAVLAELYKEVAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASLKAED 236


                  ..
gi 1088185074 244 FA 245
Cdd:pfam00121 237 FL 238
PRK13962 PRK13962
bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional
 5-245 1.17e-65

bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional


Pssm-ID: 237572 [Multi-domain]  Cd Length: 645  Bit Score: 214.98  E-value: 1.17e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074   5 KKLIVANWKMNpGTAAEARSlFLASRRAAAEARRLSVVVCPPFPFLSLFSRLANGV-ISLGSQDACWRNGGPYTGEVSPE 83
Cdd:PRK13962  398 KPIIAGNWKMN-KTPAEAKE-FVNELKKYVKDAQAEVVVCPPFTALPSVKEAVDGSnIKLGAQNVFYEEKGAYTGEISGP 475

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  84 ILKDIGVTISIIGHSERRAR-GETDDIVSRKAQAVVREGITALVCVGER-TRDENGDFFATLREQIKASFSKVQRRFLSD 161
Cdd:PRK13962  476 MLAEIGVEYVIIGHSERRQYfGETDELVNKKVLAALKAGLTPILCVGETlDERESGITFDVVRLQLKAALNGLSAEQVKK 555

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074 162 IIIAYEPLWAIGRNwrDAATPEAVREAAIFIRKVMADIFGDAGAQAL-VLYGGSVGPENAQALLRDGDIAGFLVGHESLE 240
Cdd:PRK13962  556 VVIAYEPVWAIGTG--KVATPEQAQEVHAFIRKLVAELYGEEAARKVrILYGGSVKSENAAGLFNQPDIDGGLVGGASLK 633


                  ....*
gi 1088185074 241 PDAFA 245
Cdd:PRK13962  634 AQEFA 638
PTZ00333 PTZ00333
triosephosphate isomerase; Provisional
 1-242 1.32e-65

triosephosphate isomerase; Provisional


Pssm-ID: 240365  Cd Length: 255  Bit Score: 204.38  E-value: 1.32e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074   1 MKKGKKLIVANWKMNpGTAAEARSLFLASRRAAAEARRLSVVVCPPFPFLSLF-SRLANGVISLGSQDACWRNGGPYTGE 79
Cdd:PTZ00333    1 MMKRKPFVGGNWKCN-GTKASIKELIDSFNKLKFDPNNVDVVVAPPSLHIPLVqEKLKNKNFKISSQNVSLTGSGAFTGE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  80 VSPEILKDIGVTISIIGHSERRAR-GETDDIVSRKAQAVVREGITALVCVGERTRD-ENGDFFATLREQIKASFSKVQRR 157
Cdd:PTZ00333   80 ISAEMLKDLGINWTILGHSERRQYfGETNEIVAQKVKNALENGLKVILCIGETLEErEAGQTSDVLSKQLEAIVKKVSDE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074 158 FLSDIIIAYEPLWAIGRNwrDAATPEAVREAAIFIRKVMADIFGDAGAQAL-VLYGGSVGPENAQALLRDGDIAGFLVGH 236
Cdd:PTZ00333  160 AWDNIVIAYEPVWAIGTG--KVATPEQAQEVHAFIRKWLAEKVGADVAEATrIIYGGSVNEKNCKELIKQPDIDGFLVGG 237


                  ....*.
gi 1088185074 237 ESLEPD 242
Cdd:PTZ00333  238 ASLKPD 243
PRK14565 PRK14565
triosephosphate isomerase; Provisional
 7-245 4.37e-50

triosephosphate isomerase; Provisional


Pssm-ID: 237758  Cd Length: 237  Bit Score: 164.16  E-value: 4.37e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074   7 LIVANWKMNpGTAAEARSlFLAS--RRAAAEARRLSVVVCPPFPFLSLFSRLANgVISLGSQDACWRNGGPYTGEVSPEI 84
Cdd:PRK14565    4 LIVANWKMN-GDFSLFSS-FLKElsNKLANNEITLKLVICPPFTAMSSFVECNP-NIKLGAQNCFYGSSGGYTGEISAKM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  85 LKDIGVTISIIGHSERR-ARGETDDIVSRKAQAVVREGITALVCVGERTRD-ENGDFFATLREQIKASFSKvQRRFlsdi 162
Cdd:PRK14565   81 LKECGCSYVILGHSERRsTFHETDSDIRLKAESAIESGLIPIICVGETLEDrENGMTKDVLLEQCSNCLPK-HGEF---- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074 163 IIAYEPLWAIGRNwrdaATP--EAVREAAIFIRKvmadifgdAGAQALVLYGGSVGPENAQALLRDGDIAGFLVGHESLE 240
Cdd:PRK14565  156 IIAYEPVWAIGGS----TIPsnDAIAEAFEIIRS--------YDSKSHIIYGGSVNQENIRDLKSINQLSGVLVGSASLD 223


                  ....*
gi 1088185074 241 PDAFA 245
Cdd:PRK14565  224 VDSFC 228
PLN02561 PLN02561
triosephosphate isomerase
 4-242 1.21e-38

triosephosphate isomerase


Pssm-ID: 178175  Cd Length: 253  Bit Score: 134.95  E-value: 1.21e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074   4 GKKLIVA-NWKMNpGTAAEARSLF-LASRRAAAEARRLSVVVCPPFPFLSLFSRLANGVISLGSQDaCW-RNGGPYTGEV 80
Cdd:PLN02561    2 ARKFFVGgNWKCN-GTVEEVKKIVtTLNEAEVPSEDVVEVVVSPPFVFLPLVKSLLRPDFQVAAQN-CWvKKGGAFTGEI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  81 SPEILKDIGVTISIIGHSERRAR-GETDDIVSRKAQAVVREGITALVCVGERTRD-ENGDFFATLREQIKASFSKVQRrf 158
Cdd:PLN02561   80 SAEMLVNLGIPWVILGHSERRALlGESNEFVGDKVAYALSQGLKVIACVGETLEQrESGSTMDVVAAQTKAIADKVSD-- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074 159 LSDIIIAYEPLWAIGRNwrDAATPEAVREAAIFIRKVMADIFG-DAGAQALVLYGGSVGPENAQALLRDGDIAGFLVGHE 237
Cdd:PLN02561  158 WANVVLAYEPVWAIGTG--KVATPAQAQEVHDELRKWLHKNVSpEVAATTRIIYGGSVTGANCKELAAQPDVDGFLVGGA 235


                  ....*
gi 1088185074 238 SLEPD 242
Cdd:PLN02561  236 SLKPE 240
PRK15492 PRK15492
triosephosphate isomerase; Provisional
 61-244 7.93e-37

triosephosphate isomerase; Provisional


Pssm-ID: 185389  Cd Length: 260  Bit Score: 130.50  E-value: 7.93e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  61 ISLGSQDACWRNGGPYTGEVSPEILKDIGVTISIIGHSERRAR-GETDDIVSRKAQAVVREGITALVCVGERTRDEN-GD 138
Cdd:PRK15492   66 IIIGAQNMNPNDNGQFTGDISPLMLKEIGTQLVMIGHSERRHKfGETDQEENAKVLAALKHDFTTLLCVGETLEQKNyGI 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074 139 FFATLREQIKASFSKVQRRFLSDIIIAYEPLWAIGRNWRDAATPEAVREAAIfIRKVMADIFGDAGAQALVLYGGSVGPE 218
Cdd:PRK15492  146 SDEILRTQLKIGLHGINPDQLAKLRIAYEPVWAIGEAGIPASADYADEKHAV-IKQCLIELFGDAGDDIPVFYGGSVNAE 224

                         170       180
                  ....*....|....*....|....*.
gi 1088185074 219 NAQALLRDGDIAGFLVGHESLEPDAF 244
Cdd:PRK15492  225 NANELFGQPHIDGLFIGRSAWDADKF 250
PRK14905 PRK14905
triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; ...
 54-244 7.90e-34

triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; Provisional


Pssm-ID: 184898 [Multi-domain]  Cd Length: 355  Bit Score: 125.14  E-value: 7.90e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  54 SRLANGVISLGSQDACWRNGGPYTGEVSPEILKDIGVTISIIGHSERR-ARGETDDIVSRKAQAVVREGITALVCVGERT 132
Cdd:PRK14905   60 SETGHPKIKIGAQNMNAKDKGQFTGEISPLMLKELGIELVMIGHSERRhVLKETDQEENEKVLAALKHGFITLLCIGETL 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074 133 RDENGDFF-ATLREQIKASFSKVQRRFLSDIIIAYEPLWAIGRNwRDAATPEAVREAAIFIRKVMADIFGDAGAQALVLY 211
Cdd:PRK14905  140 EQKNYNISdEVLRTQLKIGLHGVSAEQLPHLFIAYEPVWAIGEG-GIPASAEYADEKHAIIKQCLFELFAEESKKIPVLY 218

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1088185074 212 GGSVGPENAQALLRDGDIAGFLVGHESLEPDAF 244
Cdd:PRK14905  219 GGSVNLENANELIMKPHIDGLFIGRSAWDAQCF 251
PLN02429 PLN02429
triosephosphate isomerase
 39-245 2.46e-33

triosephosphate isomerase


Pssm-ID: 166070  Cd Length: 315  Bit Score: 122.98  E-value: 2.46e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  39 LSVVVCPPFPFLSLFSRLANGVISLGSQDACWRNGGPYTGEVSPEILKDIGVTISIIGHSERR-ARGETDDIVSRKAQAV 117
Cdd:PLN02429   97 VDVVVSPPFVYIDQVKSSLTDRIDISGQNSWVGKGGAFTGEISVEQLKDLGCKWVILGHSERRhVIGEKDEFIGKKAAYA 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074 118 VREGITALVCVGERTRD-ENGDFFATLREQIKASFSKVQRrfLSDIIIAYEPLWAIGRNwrDAATPEAVREAAIFIRK-V 195
Cdd:PLN02429  177 LSEGLGVIACIGEKLEErEAGKTFDVCFAQLKAFADAVPS--WDNIVVAYEPVWAIGTG--KVASPQQAQEVHVAVRGwL 252

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1088185074 196 MADIFGDAGAQALVLYGGSVGPENAQALLRDGDIAGFLVGHESLEPDAFA 245
Cdd:PLN02429  253 KKNVSEEVASKTRIIYGGSVNGGNSAELAKEEDIDGFLVGGASLKGPEFA 302
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 7-242 9.77e-22

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 89.48  E-value: 9.77e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074   7 LIVANWKMNPGTAAEARSLFLASRRAAAEARRLSVVVCPPFPFLSLFSRLANgvISLGSQDACWRNGGPYTGEVSPEILK 86
Cdd:TIGR00419   1 LVIGNWKTYNESRGMRALEVAKIAEEVASEAGVAVAVAPPFVDLPMIKREVE--IPVYAQHVDAVLSGAHTGEISAEMLK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  87 DIGVTISIIGHSERRARgETDdiVSRKAQAVVREGITALVCVGertrdengdffATLREQIKASFSKVqrrflsdiIIAY 166
Cdd:TIGR00419  79 DIGAKGTLINHSERRMK-LAD--IEKKIARLKELGLTSVVCTN-----------NVLTTAAAAALEPD--------VVAV 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1088185074 167 EPLWAIGRNwrDAATPEAVREAAIFIRkVMADIfgdaGAQALVLYGGSVGPENAQALLRDGDIAGFLVGHESLEPD 242
Cdd:TIGR00419 137 EPPELIGTG--IPVSPAQPEVVHGSVR-AVKEV----NESVRVLCGAGISTGEDAELAAQLGAEGVLLASGSLKAD 205
PRK04302 PRK04302
triosephosphate isomerase; Provisional
 40-128 4.11e-06

triosephosphate isomerase; Provisional


Pssm-ID: 235274  Cd Length: 223  Bit Score: 46.40  E-value: 4.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088185074  40 SVVVCPPFPFLSLFSRLANgvISLGSQDACWRNGGPYTGEVSPEILKDIGVTISIIGHSERRAR-GETDDIVSRkAQAVv 118
Cdd:PRK04302   38 RIAVAPQALDIRRVAEEVD--IPVYAQHVDPVEPGSHTGHILPEAVKDAGAVGTLINHSERRLTlADIEAVVER-AKKL- 113

                          90
                  ....*....|
gi 1088185074 119 reGITALVCV 128
Cdd:PRK04302  114 --GLESVVCV 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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