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Conserved domains on  [gi|1090923719|gb|OHO64898|]
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arsenic transporter [Staphylococcus sp. HMSC036A09]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsB_NhaD_permease super family cl21473
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 4-55 9.63e-16

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


The actual alignment was detected with superfamily member PRK15445:

Pssm-ID: 473875  Cd Length: 427  Bit Score: 68.66  E-value: 9.63e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1090923719   4 VLVITIFFITVTLIIWQPKGLDIGISAVIGALLAIVTGVVSVSDILEVTSIV 55
Cdd:PRK15445    1 LLAIAIFLLTLVLVIWQPKGLGIGWSALLGAVLALLTGVVSLGDVPVVWGIV 52
 
Name Accession Description Interval E-value
PRK15445 PRK15445
arsenical efflux pump membrane protein ArsB;
4-55 9.63e-16

arsenical efflux pump membrane protein ArsB;


Pssm-ID: 185342  Cd Length: 427  Bit Score: 68.66  E-value: 9.63e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1090923719   4 VLVITIFFITVTLIIWQPKGLDIGISAVIGALLAIVTGVVSVSDILEVTSIV 55
Cdd:PRK15445    1 LLAIAIFLLTLVLVIWQPKGLGIGWSALLGAVLALLTGVVSLGDVPVVWGIV 52
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 5-55 5.23e-09

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 49.57  E-value: 5.23e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1090923719   5 LVITIFFITVTLIIWQPKGLDIGISAVIGALLAIVTGVVSVSDILEVTSIV 55
Cdd:cd01118     1 LAIAIFVLTLVLVIWRPFGLPEAVWAVLGAVIALILGLVSPHDALEVWGIV 51
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
3-51 2.00e-04

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 36.64  E-value: 2.00e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1090923719   3 TVLVITIFFITVTLIIWQPKGLDIGISAVIGALLAIVTGVVSVSDILEV 51
Cdd:COG1055     2 MILALAIFVLTYLLIILEPRGLNRAVAALLGAALLLLLGVVSLEDALEA 50
 
Name Accession Description Interval E-value
PRK15445 PRK15445
arsenical efflux pump membrane protein ArsB;
4-55 9.63e-16

arsenical efflux pump membrane protein ArsB;


Pssm-ID: 185342  Cd Length: 427  Bit Score: 68.66  E-value: 9.63e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1090923719   4 VLVITIFFITVTLIIWQPKGLDIGISAVIGALLAIVTGVVSVSDILEVTSIV 55
Cdd:PRK15445    1 LLAIAIFLLTLVLVIWQPKGLGIGWSALLGAVLALLTGVVSLGDVPVVWGIV 52
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 5-55 5.23e-09

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 49.57  E-value: 5.23e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1090923719   5 LVITIFFITVTLIIWQPKGLDIGISAVIGALLAIVTGVVSVSDILEVTSIV 55
Cdd:cd01118     1 LAIAIFVLTLVLVIWRPFGLPEAVWAVLGAVIALILGLVSPHDALEVWGIV 51
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
3-51 2.00e-04

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 36.64  E-value: 2.00e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1090923719   3 TVLVITIFFITVTLIIWQPKGLDIGISAVIGALLAIVTGVVSVSDILEV 51
Cdd:COG1055     2 MILALAIFVLTYLLIILEPRGLNRAVAALLGAALLLLLGVVSLEDALEA 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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