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Conserved domains on  [gi|1090933128|gb|OHO73999|]
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ferritin [Bacillus sp. HMSC036E02]

Protein Classification

DUF3298 and DUF4163 domain-containing protein( domain architecture ID 10617832)

DUF3298 and DUF4163 domain-containing protein similar to Bacillus subtilis anti-sigma-V factor RsiV that negatively regulates SigV activity through direct interaction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PdaC pfam13739
Deacetylase PdaC; This domain forms an alpha-beta-two layer sandwich. It is found in the ...
 40-136 2.90e-25

Deacetylase PdaC; This domain forms an alpha-beta-two layer sandwich. It is found in the Bacillus subtilis proteins anti-sigma-V factor RsiV, which downregulates SigV activity, and peptidoglycan-N-acetylmuramic acid deacetylase PdaC, which catalyzes the deacetylation of N-acetylmuramic acid which makes the peptidoglycan resistant to lysosyme. It is found in association with Heat-shock cognate 70kd protein 44kd ATPase, pfam11738.


:

Pssm-ID: 463973  Cd Length: 94  Bit Score: 95.49  E-value: 2.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090933128  40 KGKKPYIEYQINRPSFHEFSDSKFQNKLNLYYKKSTDKFKTKLEKEAKKYYKEtegSSTPFHPYVANVDYKVSLNKPPFL 119
Cdd:pfam13739   1 KEETDYLEIDIKYPVISGLKNKELQKAINKKLEKDIDAFIKEYEKEAKEEAKK---NGFPFRPYELEVDYEVKYNNNNIL 77

                          90
                  ....*....|....*..
gi 1090933128 120 SLYVNYYQYTGGAHGLY 136
Cdd:pfam13739  78 SLVFNYYQYTGGAHGMT 94
DUF3298 pfam11738
Protein of unknown function (DUF3298); This family of bacterial protein C-terminal regions is ...
 156-228 1.36e-13

Protein of unknown function (DUF3298); This family of bacterial protein C-terminal regions is highly conserved but the function is not known. Several members are annotated as being endo-1,4-beta-xylanase-like, but this could not be confirmed, and the structure can be defined as a heat-shock cognate 70kd protein 44kd ATPase.


:

Pssm-ID: 463337  Cd Length: 81  Bit Score: 64.33  E-value: 1.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090933128 156 LFEQKDKYKDVIRAEIVRQIKQNESIYFPDATEKVMSMKKF-------HFFLEPDNLVIYFPLYEIAPYSSGIPQFRIPY 228
Cdd:pfam11738   1 LFKPGSAYLEALSELIKEQLKKQAKEDPLDDYEELDEPFDFddikeyqNFYLTDDGLVFYFNPYEIAPYAAGPPEFTIPY 80
 
Name Accession Description Interval E-value
PdaC pfam13739
Deacetylase PdaC; This domain forms an alpha-beta-two layer sandwich. It is found in the ...
 40-136 2.90e-25

Deacetylase PdaC; This domain forms an alpha-beta-two layer sandwich. It is found in the Bacillus subtilis proteins anti-sigma-V factor RsiV, which downregulates SigV activity, and peptidoglycan-N-acetylmuramic acid deacetylase PdaC, which catalyzes the deacetylation of N-acetylmuramic acid which makes the peptidoglycan resistant to lysosyme. It is found in association with Heat-shock cognate 70kd protein 44kd ATPase, pfam11738.


Pssm-ID: 463973  Cd Length: 94  Bit Score: 95.49  E-value: 2.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090933128  40 KGKKPYIEYQINRPSFHEFSDSKFQNKLNLYYKKSTDKFKTKLEKEAKKYYKEtegSSTPFHPYVANVDYKVSLNKPPFL 119
Cdd:pfam13739   1 KEETDYLEIDIKYPVISGLKNKELQKAINKKLEKDIDAFIKEYEKEAKEEAKK---NGFPFRPYELEVDYEVKYNNNNIL 77

                          90
                  ....*....|....*..
gi 1090933128 120 SLYVNYYQYTGGAHGLY 136
Cdd:pfam13739  78 SLVFNYYQYTGGAHGMT 94
DUF3298 pfam11738
Protein of unknown function (DUF3298); This family of bacterial protein C-terminal regions is ...
 156-228 1.36e-13

Protein of unknown function (DUF3298); This family of bacterial protein C-terminal regions is highly conserved but the function is not known. Several members are annotated as being endo-1,4-beta-xylanase-like, but this could not be confirmed, and the structure can be defined as a heat-shock cognate 70kd protein 44kd ATPase.


Pssm-ID: 463337  Cd Length: 81  Bit Score: 64.33  E-value: 1.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090933128 156 LFEQKDKYKDVIRAEIVRQIKQNESIYFPDATEKVMSMKKF-------HFFLEPDNLVIYFPLYEIAPYSSGIPQFRIPY 228
Cdd:pfam11738   1 LFKPGSAYLEALSELIKEQLKKQAKEDPLDDYEELDEPFDFddikeyqNFYLTDDGLVFYFNPYEIAPYAAGPPEFTIPY 80
 
Name Accession Description Interval E-value
PdaC pfam13739
Deacetylase PdaC; This domain forms an alpha-beta-two layer sandwich. It is found in the ...
 40-136 2.90e-25

Deacetylase PdaC; This domain forms an alpha-beta-two layer sandwich. It is found in the Bacillus subtilis proteins anti-sigma-V factor RsiV, which downregulates SigV activity, and peptidoglycan-N-acetylmuramic acid deacetylase PdaC, which catalyzes the deacetylation of N-acetylmuramic acid which makes the peptidoglycan resistant to lysosyme. It is found in association with Heat-shock cognate 70kd protein 44kd ATPase, pfam11738.


Pssm-ID: 463973  Cd Length: 94  Bit Score: 95.49  E-value: 2.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090933128  40 KGKKPYIEYQINRPSFHEFSDSKFQNKLNLYYKKSTDKFKTKLEKEAKKYYKEtegSSTPFHPYVANVDYKVSLNKPPFL 119
Cdd:pfam13739   1 KEETDYLEIDIKYPVISGLKNKELQKAINKKLEKDIDAFIKEYEKEAKEEAKK---NGFPFRPYELEVDYEVKYNNNNIL 77

                          90
                  ....*....|....*..
gi 1090933128 120 SLYVNYYQYTGGAHGLY 136
Cdd:pfam13739  78 SLVFNYYQYTGGAHGMT 94
DUF3298 pfam11738
Protein of unknown function (DUF3298); This family of bacterial protein C-terminal regions is ...
 156-228 1.36e-13

Protein of unknown function (DUF3298); This family of bacterial protein C-terminal regions is highly conserved but the function is not known. Several members are annotated as being endo-1,4-beta-xylanase-like, but this could not be confirmed, and the structure can be defined as a heat-shock cognate 70kd protein 44kd ATPase.


Pssm-ID: 463337  Cd Length: 81  Bit Score: 64.33  E-value: 1.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090933128 156 LFEQKDKYKDVIRAEIVRQIKQNESIYFPDATEKVMSMKKF-------HFFLEPDNLVIYFPLYEIAPYSSGIPQFRIPY 228
Cdd:pfam11738   1 LFKPGSAYLEALSELIKEQLKKQAKEDPLDDYEELDEPFDFddikeyqNFYLTDDGLVFYFNPYEIAPYAAGPPEFTIPY 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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