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Conserved domains on  [gi|1091153873|gb|OHQ83936|]
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two-component sensor histidine kinase [Streptococcus sp. HMSC074F09]

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

EC:  2.7.13.3
Gene Ontology:  GO:0004673|GO:0007165|GO:0005524|GO:0000160|GO:0016020|GO:0000155
PubMed:  11489844|18076326|10966457|11406410|12372152|8029829

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
125-385 1.06e-52

Signal transduction histidine kinase [Signal transduction mechanisms];


:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 178.18  E-value: 1.06e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 125 LASYEVPYARRFLILVFTIFGFCLLAAVSLYLSRFIVGPVETEMTREKQFVSDASHELKTPIAAIRANVQVLEQQIPG-- 202
Cdd:COG0642    64 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEeq 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 203 NRYLDHVVSETKRMEFLIEDLLNLSRLDEKRSKVNFKKLNLSVLCQEVLLTYESLAYEEEKCLNDTIEDDVWIV-GEESQ 281
Cdd:COG0642   144 REYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVrGDPDR 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 282 IKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFYQAKDDHADSlSFGLGLSIAKAIV 361
Cdd:COG0642   224 LRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG-GTGLGLAIVKRIV 302

                         250       260
                  ....*....|....*....|....*
gi 1091153873 362 ERHKGRIRAYQEKDQ-LRLEVQLPI 385
Cdd:COG0642   303 ELHGGTIEVESEPGKgTTFTVTLPL 327
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
125-385 1.06e-52

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 178.18  E-value: 1.06e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 125 LASYEVPYARRFLILVFTIFGFCLLAAVSLYLSRFIVGPVETEMTREKQFVSDASHELKTPIAAIRANVQVLEQQIPG-- 202
Cdd:COG0642    64 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEeq 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 203 NRYLDHVVSETKRMEFLIEDLLNLSRLDEKRSKVNFKKLNLSVLCQEVLLTYESLAYEEEKCLNDTIEDDVWIV-GEESQ 281
Cdd:COG0642   144 REYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVrGDPDR 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 282 IKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFYQAKDDHADSlSFGLGLSIAKAIV 361
Cdd:COG0642   224 LRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG-GTGLGLAIVKRIV 302

                         250       260
                  ....*....|....*....|....*
gi 1091153873 362 ERHKGRIRAYQEKDQ-LRLEVQLPI 385
Cdd:COG0642   303 ELHGGTIEVESEPGKgTTFTVTLPL 327
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 180-369 1.09e-27

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 113.79  E-value: 1.09e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 180 HELKTPIAAIRANVQVLEQQIPGN---RYLDHVVSETKRMEFLIEDLLNLSRLDEKRSKVNFKKLNLSVLCQEVLLTYES 256
Cdd:PRK11100  265 HELKSPLAAIRGAAELLQEDPPPEdraRFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREA 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 257 LAyeEEKCLNDTIE-DDVWIVGEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNP-SAI--YSkevMDN 332
Cdd:PRK11100  345 QA--AAKGITLRLRpDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQgPGIpdYA---LPR 419

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1091153873 333 LFERFYqakddhadSL--------SFGLGLSIAKAIVERHKGRIR 369
Cdd:PRK11100  420 IFERFY--------SLprpangrkSTGLGLAFVREVARLHGGEVT 456
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 169-384 1.88e-24

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 104.39  E-value: 1.88e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 169 TREKQFVSDASHELKTPIAAIRANVQV-LEQQIPGNRYLDHVVS---ETKRMEFLIEDLLNLSRLDEKRSKVNFKKLNLS 244
Cdd:TIGR01386 239 QRLSQFSADLAHELRTPLTNLLGQTQVaLSQPRTGEEYREVLESnleELERLSRMVSDMLFLARADNGQLALERVRLDLA 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 245 VLCQEVLLTYESLAyeEEKCLNDTIEDDVWIVGEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAI 324
Cdd:TIGR01386 319 AELAKVAEYFEPLA--EERGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPG 396

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1091153873 325 YSKEVMDNLFERFYQAKDDHADSLSF-GLGLSIAKAIVERHKGRIRAYQEKDQLRLEVQLP 384
Cdd:TIGR01386 397 IPPEHLSRLFDRFYRVDPARSNSGEGtGLGLAIVRSIMEAHGGRASAESPDGKTRFILRFP 457
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 282-376 1.39e-22

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 91.13  E-value: 1.39e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 282 IKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFYQAKDDHADSlSFGLGLSIAKAIV 361
Cdd:cd00075     1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGG-GTGLGLAIVRRIV 79

                          90
                  ....*....|....*
gi 1091153873 362 ERHKGRIRAYQEKDQ 376
Cdd:cd00075    80 EAHGGRITVESEPGG 94
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 277-385 4.06e-21

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 87.70  E-value: 4.06e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873  277 GEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFYQAKDDHADSLSFGLGLSI 356
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 1091153873  357 AKAIVERHKGRIRAYQEKDQ-LRLEVQLPI 385
Cdd:smart00387  81 VKKLVELHGGEISVESEPGGgTTFTITLPL 110
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 277-386 2.74e-16

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 73.94  E-value: 2.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 277 GEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRkAILTISNPSAIYSKEVMDNLFERFYQAkdDHADSLSFGLGLSI 356
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTA--DKRGGGGTGLGLSI 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1091153873 357 AKAIVERHKGRIRAYQEKDQ-LRLEVQLPID 386
Cdd:pfam02518  78 VRKLVELLGGTITVESEPGGgTTVTLTLPLA 108
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
125-385 1.06e-52

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 178.18  E-value: 1.06e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 125 LASYEVPYARRFLILVFTIFGFCLLAAVSLYLSRFIVGPVETEMTREKQFVSDASHELKTPIAAIRANVQVLEQQIPG-- 202
Cdd:COG0642    64 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEeq 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 203 NRYLDHVVSETKRMEFLIEDLLNLSRLDEKRSKVNFKKLNLSVLCQEVLLTYESLAYEEEKCLNDTIEDDVWIV-GEESQ 281
Cdd:COG0642   144 REYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVrGDPDR 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 282 IKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFYQAKDDHADSlSFGLGLSIAKAIV 361
Cdd:COG0642   224 LRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG-GTGLGLAIVKRIV 302

                         250       260
                  ....*....|....*....|....*
gi 1091153873 362 ERHKGRIRAYQEKDQ-LRLEVQLPI 385
Cdd:COG0642   303 ELHGGTIEVESEPGKgTTFTVTLPL 327
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
172-385 7.11e-52

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 177.82  E-value: 7.11e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 172 KQFVSDASHELKTPIAAIRANVQVLEQQIPGN-----RYLDHVVSETKRMEFLIEDLLNLSRLDEKRSKVNFKKLNLSVL 246
Cdd:COG5002   166 REFVANVSHELRTPLTSIRGYLELLLDGAADDpeerrEYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAEL 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 247 CQEVLLTYESLAYEEEKCLN-DTIEDDVWIVGEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIY 325
Cdd:COG5002   246 LEEVVEELRPLAEEKGIELElDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGI 325

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1091153873 326 SKEVMDNLFERFYQAkdDHADSLS---FGLGLSIAKAIVERHKGRIRAYQEKDQ-LRLEVQLPI 385
Cdd:COG5002   326 PEEDLPRIFERFYRV--DKSRSREtggTGLGLAIVKHIVEAHGGRIWVESEPGKgTTFTITLPL 387
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
167-385 1.34e-51

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 172.40  E-value: 1.34e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 167 EMTREK-QFVSDASHELKTPIAAIRANVQVLEQQIPGN-----RYLDHVVSETKRMEFLIEDLLNLSRLDEKRSKVNFKK 240
Cdd:COG2205    11 ELERLKsEFLANVSHELRTPLTSILGAAELLLDEEDLSpeerrELLEIIRESAERLLRLIEDLLDLSRLESGKLSLELEP 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 241 LNLSVLCQEVLLTYESLAYEEEKCLN-DTIEDDVWIVGEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTIS 319
Cdd:COG2205    91 VDLAELLEEAVEELRPLAEEKGIRLElDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVRISVS 170

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1091153873 320 NPSAIYSKEVMDNLFERFYQAKDDHADSlSFGLGLSIAKAIVERHKGRIRAYQEKDQ-LRLEVQLPI 385
Cdd:COG2205   171 DNGPGIPEEELERIFERFYRGDNSRGEG-GTGLGLAIVKRIVEAHGGTIWVESEPGGgTTFTVTLPL 236
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 179-385 8.14e-28

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 113.52  E-value: 8.14e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 179 SHELKTPIAAIRANVQVLEQQIPGN---------RYLDHVVSETKRMEFLIEDLLNLSRLdekrSKVNFKKLNLSVLCQE 249
Cdd:COG5000   209 AHEIKNPLTPIQLSAERLRRKLADKleedredleRALDTIIRQVDRLKRIVDEFLDFARL----PEPQLEPVDLNELLRE 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 250 VLLTYESLAYEEE-KCLNDTIEDDVWIVGEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTIS-NPSAIySK 327
Cdd:COG5000   285 VLALYEPALKEKDiRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSdNGPGI-PE 363

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1091153873 328 EVMDNLFERFYQAKDDhadslSFGLGLSIAKAIVERHKGRIRAYQEKDQ-LRLEVQLPI 385
Cdd:COG5000   364 EVLERIFEPFFTTKPK-----GTGLGLAIVKKIVEEHGGTIELESRPGGgTTFTIRLPL 417
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 180-369 1.09e-27

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 113.79  E-value: 1.09e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 180 HELKTPIAAIRANVQVLEQQIPGN---RYLDHVVSETKRMEFLIEDLLNLSRLDEKRSKVNFKKLNLSVLCQEVLLTYES 256
Cdd:PRK11100  265 HELKSPLAAIRGAAELLQEDPPPEdraRFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREA 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 257 LAyeEEKCLNDTIE-DDVWIVGEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNP-SAI--YSkevMDN 332
Cdd:PRK11100  345 QA--AAKGITLRLRpDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQgPGIpdYA---LPR 419

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1091153873 333 LFERFYqakddhadSL--------SFGLGLSIAKAIVERHKGRIR 369
Cdd:PRK11100  420 IFERFY--------SLprpangrkSTGLGLAFVREVARLHGGEVT 456
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 173-370 2.18e-27

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 113.34  E-value: 2.18e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 173 QFVSDASHELKTPIAAIRANVQVLEQQIP------GNRYLDHVVSETKRMEFLIEDLLNLSRLDekRSKVNFKKLNLSVL 246
Cdd:COG4251   284 QFAYVASHDLREPLRKISGFSQLLEEDYGdkldeeGREYLERIRDAAERMQALIDDLLAYSRVG--RQELEFEPVDLNEL 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 247 CQEVLLTYESLAyeEEKCLNDTIEDDVWIVGEESQIKQILIILLDNAIRHSLSKS--EIQFSLKQARRKAILTISnpsai 324
Cdd:COG4251   362 LEEVLEDLEPRI--EERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGEppRIEIGAEREGGEWVFSVR----- 434

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1091153873 325 yskevmDN-----------LFERFYQ--AKDDHADSlsfGLGLSIAKAIVERHKGRIRA 370
Cdd:COG4251   435 ------DNgigidpeyaekIFEIFQRlhSRDEYEGT---GIGLAIVKKIVERHGGRIWV 484
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 169-384 1.88e-24

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 104.39  E-value: 1.88e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 169 TREKQFVSDASHELKTPIAAIRANVQV-LEQQIPGNRYLDHVVS---ETKRMEFLIEDLLNLSRLDEKRSKVNFKKLNLS 244
Cdd:TIGR01386 239 QRLSQFSADLAHELRTPLTNLLGQTQVaLSQPRTGEEYREVLESnleELERLSRMVSDMLFLARADNGQLALERVRLDLA 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 245 VLCQEVLLTYESLAyeEEKCLNDTIEDDVWIVGEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAI 324
Cdd:TIGR01386 319 AELAKVAEYFEPLA--EERGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPG 396

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1091153873 325 YSKEVMDNLFERFYQAKDDHADSLSF-GLGLSIAKAIVERHKGRIRAYQEKDQLRLEVQLP 384
Cdd:TIGR01386 397 IPPEHLSRLFDRFYRVDPARSNSGEGtGLGLAIVRSIMEAHGGRASAESPDGKTRFILRFP 457
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 173-385 2.37e-24

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 102.95  E-value: 2.37e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 173 QFVSDASHELKTPIAAIRANVQVLEQQIPGN-------RYLDHVVSETKRMEFLIEDLLNLSRLDEKRskvnFKKLNLSV 245
Cdd:COG4191   144 ELAAGIAHEINNPLAAILGNAELLRRRLEDEpdpeelrEALERILEGAERAAEIVRSLRAFSRRDEEE----REPVDLNE 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 246 LCQEVL-LTYESLAYEEEKCLNDTIEDDVWIVGEESQIKQILIILLDNAIrHSLSKS---EIQFSLKQARRKAILTIS-N 320
Cdd:COG4191   220 LIDEALeLLRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAI-DAMEEGeggRITISTRREGDYVVISVRdN 298

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1091153873 321 PSAIySKEVMDNLFERFYQAKDDHADSlsfGLGLSIAKAIVERHKGRIRAYQEKDQ-LRLEVQLPI 385
Cdd:COG4191   299 GPGI-PPEVLERIFEPFFTTKPVGKGT---GLGLSISYGIVEKHGGRIEVESEPGGgTTFTITLPL 360
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
180-369 2.27e-23

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 99.92  E-value: 2.27e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 180 HELKTPIAAIRANVQVLEQQIPGN---RYLDHVVSETKRMEFLIEDLLNLSRldekRSKVNFKKLNLSVLCQEVLLTYES 256
Cdd:COG3852   144 HEIRNPLTGIRGAAQLLERELPDDelrEYTQLIIEEADRLNNLVDRLLSFSR----PRPPEREPVNLHEVLERVLELLRA 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 257 LAYEEEKCLNDTIEDDVWIVGEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIY----------S 326
Cdd:COG3852   220 EAPKNIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVTLGGLRPRLYVRievidngpgiP 299

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1091153873 327 KEVMDNLFERFYQAKDDHAdslsfGLGLSIAKAIVERHKGRIR 369
Cdd:COG3852   300 EEILDRIFEPFFTTKEKGT-----GLGLAIVQKIVEQHGGTIE 337
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 282-376 1.39e-22

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 91.13  E-value: 1.39e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 282 IKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFYQAKDDHADSlSFGLGLSIAKAIV 361
Cdd:cd00075     1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGG-GTGLGLAIVRRIV 79

                          90
                  ....*....|....*
gi 1091153873 362 ERHKGRIRAYQEKDQ 376
Cdd:cd00075    80 EAHGGRITVESEPGG 94
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 277-385 4.06e-21

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 87.70  E-value: 4.06e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873  277 GEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFYQAKDDHADSLSFGLGLSI 356
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 1091153873  357 AKAIVERHKGRIRAYQEKDQ-LRLEVQLPI 385
Cdd:smart00387  81 VKKLVELHGGEISVESEPGGgTTFTITLPL 110
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 179-370 2.08e-20

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 92.73  E-value: 2.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 179 SHELKTPIAAIRANVQVLEQQI--PGNRYLDHVVSETKRMEFLIEDLLNLSrldeKRSKVNFKKLNLSVLCQEVLLTYES 256
Cdd:COG5809   278 AHEIRNPLTSLKGFIQLLKDTIdeEQKTYLDIMLSELDRIESIISEFLVLA----KPQAIKYEPKDLNTLIEEVIPLLQP 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 257 LAYEEEKCLNDTIEDDV-WIVGEESQIKQILIILLDNAIRHSLSKSEIQFSLK-QARRKAILTIS-NPSAIySKEVMDNL 333
Cdd:COG5809   354 QALLKNVQIELELEDDIpDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKaEDDDKVVISVTdEGCGI-PEERLKKL 432

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1091153873 334 FERFYQAKDDHAdslsfGLGLSIAKAIVERHKGRIRA 370
Cdd:COG5809   433 GEPFYTTKEKGT-----GLGLMVSYKIIEEHGGKITV 464
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
160-384 6.11e-19

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 88.29  E-value: 6.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 160 IVGPVETEMTREKQFVSDASHELKTPIAAIRANVQVLEQQIPGNRYLDHVV----SETKRMEFLIEDLLNLSRLDEKRSK 235
Cdd:PRK09835  251 MIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLysnlEELTRMAKMVSDMLFLAQADNNQLI 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 236 VNFKKLNLSVLCQEVLLTYESLAYEEEKCLNdTIEDDVWIVGEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAI 315
Cdd:PRK09835  331 PEKKMLDLADEVGKVFDFFEAWAEERGVELR-FVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQ 409

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1091153873 316 LTISNPSAIYSKEVMDNLFERFY------QAKDDHAdslsfGLGLSIAKAIVERHKGRIRAYQEKDQLRLEVQLP 384
Cdd:PRK09835  410 LVVENPGTPIAPEHLPRLFDRFYrvdpsrQRKGEGS-----GIGLAIVKSIVVAHKGTVAVTSDARGTRFVISLP 479
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 180-375 4.18e-18

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 85.94  E-value: 4.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 180 HELKTPIAAIRANVQVLEQQIPGNR-YLDHVVSETKRMEFLIEDLLNLSrldeKRSKVNFKKLNLSVLCQEVLLTYESLA 258
Cdd:COG5805   296 HEIRNPLTSIKGFLQLLQPGIEDKEeYFDIMLSELDRIESIISEFLALA----KPQAVNKEKENINELIQDVVTLLETEA 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 259 YEEEKCLN-DTIEDDVWIVGEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERF 337
Cdd:COG5805   372 ILHNIQIRlELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPF 451

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1091153873 338 YQAKDDhadslSFGLGLSIAKAIVERHKGRIRAYQEKD 375
Cdd:COG5805   452 FTTKEK-----GTGLGLMVSYKIIENHNGTIDIDSKVG 484
PRK09303 PRK09303
histidine kinase;
180-368 8.05e-18

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 84.23  E-value: 8.05e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 180 HELKTPIAAIRANVQVLEQ-QIPGN---------RYLDHVVSETKRMEFLIEDLLNLSRLDEKRSKVNFKKLNLSVLCQE 249
Cdd:PRK09303  160 HDLRTPLTAASLALETLELgQIDEDtelkpalieQLQDQARRQLEEIERLITDLLEVGRTRWEALRFNPQKLDLGSLCQE 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 250 VLLTYESLAYEEEKCLNDTIEDDVWIV-GEESQIKQILIILLDNAIRHSLSKSEIQFS-LKQARRKAILTISNPSAIYSK 327
Cdd:PRK09303  240 VILELEKRWLAKSLEIQTDIPSDLPSVyADQERIRQVLLNLLDNAIKYTPEGGTITLSmLHRTTQKVQVSICDTGPGIPE 319

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1091153873 328 EVMDNLFE-RFYQAKDDHADSlsFGLGLSIAKAIVERHKGRI 368
Cdd:PRK09303  320 EEQERIFEdRVRLPRDEGTEG--YGIGLSVCRRIVRVHYGQI 359
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
174-370 1.06e-17

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 85.02  E-value: 1.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 174 FVSDASHELKTPIAAIRANVQVLEQQIPGN---RYLDHVVSETKRMEFLIEDLLNLSRldekRSKVNFKKLNLSVLCQEV 250
Cdd:PRK11360  393 LVAGVAHEIRNPLTAIRGYVQIWRQQTSDPpsqEYLSVVLREVDRLNKVIDQLLEFSR----PRESQWQPVSLNALVEEV 468

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 251 LLTYESLAYEEEKCLNDTIEDD---VWIVGEesQIKQILIILLDNAIRHSLSKSEIQFSLKQ-ARRKAILTISNPSAIYS 326
Cdd:PRK11360  469 LQLFQTAGVQARVDFETELDNElppIWADPE--LLKQVLLNILINAVQAISARGKIRIRTWQySDGQVAVSIEDNGCGID 546

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1091153873 327 KEVMDNLFERFYQAKDDHAdslsfGLGLSIAKAIVERHKGRIRA 370
Cdd:PRK11360  547 PELLKKIFDPFFTTKAKGT-----GLGLALSQRIINAHGGDIEV 585
PRK10337 PRK10337
sensor protein QseC; Provisional
 168-364 1.49e-16

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 80.85  E-value: 1.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 168 MTREKQFVSDASHELKTPIAAIRANVQV--LEQQIPGNRY--LDHVVSETKRMEFLIEDLLNLSRLDEKRSKVNFKKLNL 243
Cdd:PRK10337  234 MVRERRFTSDAAHELRSPLAALKVQTEVaqLSDDDPQARKkaLLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPL 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 244 SVLCQEVLLTYESLAYEEEKCLNDTIEDDVWIVGEESQIKQILII-LLDNAIRHSLSKSEIQFSLkQARRkaiLTISNPS 322
Cdd:PRK10337  314 EDLLQSAVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRnLLDNAIRYSPQGSVVDVTL-NARN---FTVRDNG 389

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1091153873 323 AIYSKEVMDNLFERFYQAKDDHAdSLSfGLGLSIAKAIVERH 364
Cdd:PRK10337  390 PGVTPEALARIGERFYRPPGQEA-TGS-GLGLSIVRRIAKLH 429
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 277-386 2.74e-16

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 73.94  E-value: 2.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 277 GEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRkAILTISNPSAIYSKEVMDNLFERFYQAkdDHADSLSFGLGLSI 356
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTA--DKRGGGGTGLGLSI 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1091153873 357 AKAIVERHKGRIRAYQEKDQ-LRLEVQLPID 386
Cdd:pfam02518  78 VRKLVELLGGTITVESEPGGgTTVTLTLPLA 108
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 168-228 4.22e-15

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 69.16  E-value: 4.22e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1091153873 168 MTREKQFVSDASHELKTPIAAIRANVQVLEQQIPGN----RYLDHVVSETKRMEFLIEDLLNLSR 228
Cdd:cd00082     1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDeeqrEYLERIREEAERLLRLINDLLDLSR 65
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
167-386 1.38e-14

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 75.05  E-value: 1.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 167 EMTREkqFVSDASHELKTPIAAIRANVQVLEQqipGNRYLD---------HVVSETKrmefLIEDLLNLSRLDekRSKVN 237
Cdd:PRK10549  238 QMRRD--FMADISHELRTPLAVLRGELEAIQD---GVRKFTpesvaslqaEVGTLTK----LVDDLHQLSLSD--EGALA 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 238 FKK--LNLSVLCQEVLLTYESLAYEEEKCLNDTIEDDVWIVGEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAI 315
Cdd:PRK10549  307 YRKtpVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLR 386

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1091153873 316 LTISNPSAIYSKEVMDNLFERFYQAKD--DHADSLSfGLGLSIAKAIVERHKGRIRA-YQEKDQLRLEVQLPID 386
Cdd:PRK10549  387 LTFADSAPGVSDEQLQKLFERFYRTEGsrNRASGGS-GLGLAICLNIVEAHNGRIIAaHSPFGGVSITVELPLE 459
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 289-384 7.01e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 67.03  E-value: 7.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 289 LLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFYQAkDDHADSLSFGLGLSIAKAIVERHKGRI 368
Cdd:cd16923     8 LLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRG-DNSRNTEGAGLGLSIAKAIIELHGGSA 86

                          90
                  ....*....|....*.
gi 1091153873 369 RAYQEKDQLRLEVQLP 384
Cdd:cd16923    87 SAEYDDNHDLFKVRLP 102
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 172-231 9.32e-14

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 65.67  E-value: 9.32e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1091153873  172 KQFVSDASHELKTPIAAIRANVQVLEQQIPGN---RYLDHVVSETKRMEFLIEDLLNLSRLDE 231
Cdd:smart00388   3 REFLANLSHELRTPLTAIRGYLELLLDTELSEeqrEYLETILREAERLLRLINDLLDLSRIEA 65
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 173-231 1.18e-13

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 65.31  E-value: 1.18e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1091153873 173 QFVSDASHELKTPIAAIRANVQVLEQQIPGN---RYLDHVVSETKRMEFLIEDLLNLSRLDE 231
Cdd:pfam00512   4 EFLANLSHELRTPLTAIRGYLELLRDEKLDEeqrEYLETILRSAERLLRLINDLLDLSRIEA 65
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
170-384 1.79e-13

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 71.15  E-value: 1.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 170 REKQFVSDASHELKTPIAAIRANVQVLEQQipGNRYLDHVVSETKRMEFLIEDLLNLSRLDEKRSKVNFKKLNLSvlcQE 249
Cdd:PRK10755  136 QERLFTADVAHELRTPLAGIRLHLELLEKQ--HHIDVAPLIARLDQMMHTVEQLLQLARAGQSFSSGHYQTVKLL---ED 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 250 VLLTY-----ESLAYEEEKCLNDTIEDDVWIVGEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAI 324
Cdd:PRK10755  211 VILPSqdelsEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPG 290

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1091153873 325 YSKEVMDNLFERFYQAKDDHADSlsfGLGLSIAKAIVERHKGR--IRAYQEKDQLRLEVQLP 384
Cdd:PRK10755  291 IDESKCGELSKAFVRMDSRYGGI---GLGLSIVSRITQLHHGQffLQNRQERSGTRAWVWLP 349
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
174-368 4.77e-12

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 66.96  E-value: 4.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 174 FVSDASHELKTPIAAIRANVQVLEQQI---PGNRYLDHVVSE-TKRMEFLIEDLLNLSRLD-----EKRSKVNFKKLnLS 244
Cdd:PRK11006  207 FFANVSHELRTPLTVLQGYLEMMQDQPlegALREKALHTMREqTQRMEGLVKQLLTLSKIEaaptiDLNEKVDVPMM-LR 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 245 VLCQEVlltyESLAYEEEKcLNDTIEDDVWIVGEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAI 324
Cdd:PRK11006  286 VLEREA----QTLSQGKHT-ITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPG 360

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1091153873 325 YSKEVMDNLFERFYQAkdDHADSLSF---GLGLSIAKAIVERHKGRI 368
Cdd:PRK11006  361 IAPEHIPRLTERFYRV--DKARSRQTggsGLGLAIVKHALSHHDSRL 405
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 179-369 7.75e-11

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 63.55  E-value: 7.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 179 SHELKTPIAAIRANVQVLEQQIPGNR------YLDHVVSETKRMEFLIEDLLNLSRldekRSKVNFKKLNLSVLCQEVLL 252
Cdd:COG4192   441 AHELNQPLNAMSMYLFSAKKALEQENyaqlptSLDKIEGLIERMDKIIKSLRQFSR----KSDTPLQPVDLRQVIEQAWE 516

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 253 TYESLAYEEEKCLndTIEDDVWIVGEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIYskEVMDN 332
Cdd:COG4192   517 LVESRAKPQQITL--HIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGW--PLVDK 592

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1091153873 333 LFERFYQAKDdhadsLSFGLGLSIAKAIVERHKGRIR 369
Cdd:COG4192   593 LFTPFTTTKE-----VGLGLGLSICRSIMQQFGGDLY 624
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
161-387 2.52e-10

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 61.87  E-value: 2.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 161 VGPVETEMTREKQFVSDASHELKTPIAAIRANVQVLEQQIPGNRYLDHVVSETKRMEFLIEDLLNLSRLDEKrSKVNFKK 240
Cdd:PRK09470  233 VTALERMMTSQQRLLSDISHELRTPLTRLQLATALLRRRQGESKELERIETEAQRLDSMINDLLVLSRNQQK-NHLERET 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 241 LNLSVLCQEVLltyESLAYEEE---KCLNDTIEDDVW-IVGEESqikqILIILLDNAIRHSL--SKSEIQFSLKQARRKA 314
Cdd:PRK09470  312 FKANSLWSEVL---EDAKFEAEqmgKSLTVSAPPGPWpINGNPN----ALASALENIVRNALrySHTKIEVAFSVDKDGL 384

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1091153873 315 ILTISNPSAIYSKEVMDNLFERFY---QAKDDHadSLSFGLGLSIAKAIVERHKGRIRAyqEKDQ---LRLEVQLPIDG 387
Cdd:PRK09470  385 TITVDDDGPGVPEEEREQIFRPFYrvdEARDRE--SGGTGLGLAIVENAIQQHRGWVKA--EDSPlggLRLTIWLPLYK 459
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 269-383 2.81e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 57.42  E-value: 2.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 269 IEDDVWIVGEESQIKQILIILLDNAIRHSLSKSEIQFSLkQARRKAILTISNPSAIYSKEVMDNLFERFYQAKDDHADSL 348
Cdd:cd16940     1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKL-SADDGAVIRVEDNGPGIDEEELEALFERFYRSDGQNYGGS 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1091153873 349 sfGLGLSIAKAIVERHKGRIRaYQEKDQLRLEVQL 383
Cdd:cd16940    80 --GLGLSIVKRIVELHGGQIF-LGNAQGGGLEAWV 111
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 289-384 4.91e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 56.18  E-value: 4.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 289 LLDNAIRHSLSKSEIQFSlkQARRKAILTISNPSAIYSKEVMDNLFERFY---QAKDdhADSLSFGLGLSIAKAIVERHK 365
Cdd:cd16949     8 VLRNALRYSPSKILLDIS--QDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdSARD--RESGGTGLGLAIAERAIEQHG 83

                          90       100
                  ....*....|....*....|
gi 1091153873 366 GRIRAYQEKDQ-LRLEVQLP 384
Cdd:cd16949    84 GKIKASNRKPGgLRVRIWLP 103
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 282-369 2.34e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 54.39  E-value: 2.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 282 IKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFYQAKDDHADSLSFGLGLSIAKAIV 361
Cdd:cd16945     5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKSTGLGLAFVQEVA 84


                  ....*...
gi 1091153873 362 ERHKGRIR 369
Cdd:cd16945    85 QLHGGRIT 92
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
134-387 4.36e-09

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 57.87  E-value: 4.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 134 RRFLILVFTIFGFCLLAAVSLYLSRFIVGP---VETEMTREKQFVS------DASHELKTPIAAIRANVQVLEQQIPG-- 202
Cdd:PRK10364  191 RNTLIILFALATVLLASLLAFFWYRRYLRSrqlLQDEMKRKEKLVAlghlaaGVAHEIRNPLSSIKGLAKYFAERAPAgg 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 203 -NRYLDHV-VSETKRMEFLIEDLLNLSRldekRSKVNFKKLNLSVLCQEVLLTYESLAYEEEKCLNDTIEDDV-WIVGEE 279
Cdd:PRK10364  271 eAHQLAQVmAKEADRLNRVVSELLELVK----PTHLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLpEIQADP 346

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 280 SQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFYQAKDDHAdslsfGLGLSIAKA 359
Cdd:PRK10364  347 DRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGT-----GLGLAVVHN 421

                         250       260
                  ....*....|....*....|....*....
gi 1091153873 360 IVERHKGRIRAYQEKDQ-LRLEVQLPIDG 387
Cdd:PRK10364  422 IVEQHGGTIQVASQEGKgATFTLWLPVNI 450
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 278-384 7.62e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 53.24  E-value: 7.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 278 EESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFYQAKDDHA-DSLSFGLGLSI 356
Cdd:cd16946     1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNrASGGSGLGLAI 80

                          90       100
                  ....*....|....*....|....*....
gi 1091153873 357 AKAIVERHKGRIRA-YQEKDQLRLEVQLP 384
Cdd:cd16946    81 CHNIALAHGGTISAeHSPLGGLRLVLTLP 109
PRK10604 PRK10604
sensor protein RstB; Provisional
 164-369 1.47e-08

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 56.15  E-value: 1.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 164 VETEMTREKQFVSDASHELKTPIAAIRANVQVLEQ-----QIPGNRYLDhvvsetkRMEFLIEDLLNLSRLDEKRSKVNF 238
Cdd:PRK10604  205 INALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNlsaaeSQALNRDIG-------QLEALIEELLTYARLDRPQNELHL 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 239 KKLNLSVLCQEVLLTYESLAYEEEKCLNDTIEDDVWIVgEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARrkAILTI 318
Cdd:PRK10604  278 SEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGAL-DMRLMERVLDNLLNNALRYAHSRVRVSLLLDGNQ--ACLIV 354

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1091153873 319 SNPSAIYSKEVMDNLFERFYQ--AKDDHAdSLSFGLGLSIAKAIVERHKGRIR 369
Cdd:PRK10604  355 EDDGPGIPPEERERVFEPFVRldPSRDRA-TGGCGLGLAIVHSIALAMGGSVN 406
envZ PRK09467
osmolarity sensor protein; Provisional
 179-385 6.12e-08

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 54.15  E-value: 6.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 179 SHELKTPIAAIR-ANvqvlEQQIPGNRYL-DHVVSETKRMEFLIEDLLNLSRLDEKRSkvnFKKLNLSVLCQEVLLTyES 256
Cdd:PRK09467  237 SHDLRTPLTRIRlAT----EMMSEEDGYLaESINKDIEECNAIIEQFIDYLRTGQEMP---MEMADLNALLGEVIAA-ES 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 257 lAYEE--EKCLNDTIEDdvwIVGEESQIKQILIILLDNAIRHSlsKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLF 334
Cdd:PRK09467  309 -GYEReiETALQPGPIE---VPMNPIAIKRALANLVVNAARYG--NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLF 382

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1091153873 335 ERFYQAkdDHA-DSLSFGLGLSIAKAIVERHKGRIR-AYQEKDQLRLEVQLPI 385
Cdd:PRK09467  383 QPFTRG--DSArGSSGTGLGLAIVKRIVDQHNGKVElGNSEEGGLSARAWLPL 433
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 280-369 1.93e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 48.96  E-value: 1.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 280 SQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFYQAKDDHADSlsfGLGLSIAKA 359
Cdd:cd16943     2 SQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGT---GLGLSLSYR 78

                          90
                  ....*....|
gi 1091153873 360 IVERHKGRIR 369
Cdd:cd16943    79 IIQKHGGTIR 88
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
174-385 2.11e-07

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 53.14  E-value: 2.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 174 FVSDASHELKTPIAAIRANVQ----VLEQQIPGNRYLDHVVSETKRMEFLIEDLLNLSRLDEKRSkvnfKKLNLSVLCQE 249
Cdd:PRK13837  453 LASGIAHNFNNILGAILGYAEmalnKLARHSRAARYIDEIISAGARARLIIDQILAFGRKGERNT----KPFDLSELVTE 528

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 250 V--LLTYeSLAYEEEKCLNDTIEDDVwIVGEESQIKQILIILLDNAIRHSLSKSEIQFSLKQ---------------ARR 312
Cdd:PRK13837  529 IapLLRV-SLPPGVELDFDQDQEPAV-VEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRaklrapkvlshgvlpPGR 606

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1091153873 313 KAILTISNPSAIYSKEVMDNLFERFYQAKDDHAdslsfGLGLSIAKAIVERHKGRIRAYQEKDQ-LRLEVQLPI 385
Cdd:PRK13837  607 YVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGT-----GLGLATVHGIVSAHAGYIDVQSTVGRgTRFDVYLPP 675
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 208-387 3.19e-07

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 51.77  E-value: 3.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 208 HVVS---ETKRMEFLIEDLLNLSRLDEKRSKVNFKKLNLSVLCqEVLLTYESLAYEEEKCLndTIEDDVWIVGEESQIKQ 284
Cdd:COG3290   205 HTISgllQLGEYDEALEYIDEISEELQELIDSLLSRIGNPVLA-ALLLGKAARARERGIDL--TIDIDSDLPDLPLSDTD 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 285 ILII---LLDNAIRHSL----SKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFY--QAKDDHadslsfGLGLS 355
Cdd:COG3290   282 LVTIlgnLLDNAIEAVEklpeEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFstKLGEGR------GLGLA 355

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1091153873 356 IAKAIVERHKGRIRAYQEKDQ-LRLEVQLPIDG 387
Cdd:COG3290   356 LVKQIVEKYGGTIEVESEEGEgTVFTVRLPKEG 388
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
171-366 9.75e-07

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 50.89  E-value: 9.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873  171 EKQFVSDASHELKTPIAAIRANVQVL-------EQQIPGnryLDHVVSETKRMEFLIEDLLNLSRLDEKRSKVNFKKLNL 243
Cdd:PRK09959   712 KSQFLATMSHEIRTPISSIMGFLELLsgsglskEQRVEA---ISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDI 788

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873  244 SVLCQEVLLTYESLAYEEEKCL--NDTIEDDVWIVGEESQIKQILIILLDNAIRHS------LSKSEIQFSLKQARRKai 315
Cdd:PRK09959   789 PTLVQNTCHSFGAIAASKSIALscSSTFPDHYLVKIDPQAFKQVLSNLLSNALKFTtegavkITTSLGHIDDNHAVIK-- 866

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1091153873  316 LTISNPSAIYSKEVMDNLFERFYQAKDDHADSLSfGLGLSIAKAIVERHKG 366
Cdd:PRK09959   867 MTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGS-GLGLMICKELIKNMQG 916
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 282-376 1.23e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 46.72  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 282 IKQILIILLDNAIRHSlSKSEIQFSLKqarrkAILTISNPSAIY----------SKEVMDNLFERFYQAkdDHADSLSF- 350
Cdd:cd16922     1 LRQILLNLLGNAIKFT-EEGEVTLRVS-----LEEEEEDGVQLRfsvedtgigiPEEQQARLFEPFSQA--DSSTTRKYg 72

                          90       100
                  ....*....|....*....|....*...
gi 1091153873 351 --GLGLSIAKAIVERHKGRIRAYQEKDQ 376
Cdd:cd16922    73 gtGLGLAISKKLVELMGGDISVESEPGQ 100
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 282-384 2.65e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 45.52  E-value: 2.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 282 IKQILIILLDNAIRHSLSKSEIQfSLKQARRKAILTISNPSAIYSKEVmDNLFERFYQAkDDHADSLSFGLGLSIAKAIV 361
Cdd:cd16950     1 LKRVLSNLVDNALRYGGGWVEVS-SDGEGNRTRIQVLDNGPGIAPEEV-DELFQPFYRG-DNARGTSGTGLGLAIVQRIS 77

                          90       100
                  ....*....|....*....|....
gi 1091153873 362 ERHKGRIR-AYQEKDQLRLEVQLP 384
Cdd:cd16950    78 DAHGGSLTlANRAGGGLCARIELP 101
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 269-371 3.38e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 46.09  E-value: 3.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 269 IEDDVWIVGEESQIKQILIILLDNAIRHSLSksEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERfyqakDDHADSL 348
Cdd:cd16954    25 ISPELRFPGERNDLMELLGNLLDNACKWCLE--FVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQR-----GQRLDEQ 97

                          90       100
                  ....*....|....*....|....*
gi 1091153873 349 S--FGLGLSIAKAIVERHKGRIRAY 371
Cdd:cd16954    98 RpgQGLGLAIAKEIVEQYGGELSLS 122
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 281-368 5.78e-06

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 44.79  E-value: 5.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 281 QIKQILIILLDNAIRHSLSKSEIQFSLKQAR-RKAILTISNPSAIYSKEVMDNLFERFYQAKDDHADSLS-FGLGLSIAK 358
Cdd:cd16925     4 KYERVVLNLLSNAFKFTPDGGRIRCILEKFRlNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGgTGLGLSIVK 83

                          90
                  ....*....|
gi 1091153873 359 AIVERHKGRI 368
Cdd:cd16925    84 EFVELHGGTV 93
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 282-369 9.36e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 43.98  E-value: 9.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 282 IKQILIILLDNAIR--HSLSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFYQAKDDhadSLSFGLGLSIAKA 359
Cdd:cd16976     1 IQQVLMNLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPV---GKGTGLGLSISYG 77

                          90
                  ....*....|
gi 1091153873 360 IVERHKGRIR 369
Cdd:cd16976    78 IVEEHGGRLS 87
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 282-368 1.07e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 43.92  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 282 IKQILIILLDNAIRhSLSKSEiqfslkqaRRKAILTISNPSAI--------------YSKEVMDNLFERFYQAKDDhads 347
Cdd:cd16920     1 IQQVLINLVRNGIE-AMSEGG--------CERRELTIRTSPADdravtisvkdtgpgIAEEVAGQLFDPFYTTKSE---- 67

                          90       100
                  ....*....|....*....|.
gi 1091153873 348 lSFGLGLSIAKAIVERHKGRI 368
Cdd:cd16920    68 -GLGMGLSICRSIIEAHGGRL 87
PRK15347 PRK15347
two component system sensor kinase;
179-357 1.29e-05

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 47.33  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 179 SHELKTPIAAIRANVQVLE--QQIPGNRYL-DHVVSETKRMEFLIEDLLNLSRLDEKRSKVNFKKLNLSVLCQEVLLTYE 255
Cdd:PRK15347  406 SHEIRTPLNGVLGALELLQntPLTAEQMDLaDTARQCTLSLLAIINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQ 485

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 256 SLAYEEEKCLNDTIEDDV--WIVGEESQIKQILIILLDNAIRHSlSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNL 333
Cdd:PRK15347  486 GPAQSKSLTLRTFVGAHVplYLHLDSLRLRQILVNLLGNAVKFT-ETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQI 564

                         170       180
                  ....*....|....*....|....
gi 1091153873 334 FERFYQAKDDHADSlsfGLGLSIA 357
Cdd:PRK15347  565 FTPFYQADTHSQGT---GLGLTIA 585
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 269-368 4.48e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 42.89  E-value: 4.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 269 IED-DVWIVGEESQIKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFYQAKDDHADS 347
Cdd:cd16947     7 IPDrPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSA 86

                          90       100
                  ....*....|....*....|..
gi 1091153873 348 LS-FGLGLSIAKAIVERHKGRI 368
Cdd:cd16947    87 KQgNGLGLTITKRLAESMGGSI 108
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 174-295 5.26e-05

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 45.28  E-value: 5.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 174 FVSDASHELKTPIAAIRANVQVLEQQIPGNRYLDHVVSETKRMEFL---IEDLLNLSRLDEKRSKV--NFKKLNLSVLCQ 248
Cdd:PRK11466  447 FLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLltiLNDILDYSAIEAGGKNVsvSDEPFEPRPLLE 526

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1091153873 249 EVLLTYESLAYEEEKCLNDTIEDDV--WIVGEESQIKQILIILLDNAIR 295
Cdd:PRK11466  527 STLQLMSGRVKGRPIRLATDIADDLptALMGDPRRIRQVITNLLSNALR 575
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 284-384 8.44e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 41.40  E-value: 8.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 284 QILIILLDNAIRHSLSKS-EIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFY-QAKDDHADSLSFGLGLSIAKAIV 361
Cdd:cd16953     3 QVLRNLIGNAISFSPPDTgRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYtERPANEAFGQHSGLGLSISRQII 82

                          90       100
                  ....*....|....*....|....*...
gi 1091153873 362 ERHKGRIRA--YQEKDQL---RLEVQLP 384
Cdd:cd16953    83 EAHGGISVAenHNQPGQVigaRFTVQLP 110
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 289-368 1.06e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 41.42  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 289 LLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFYQAKDDHADSLS-FGLGLSIAKAIVERHKGR 367
Cdd:cd16952     8 LVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGgTGLGLAIVKHVMSRHDAR 87


                  .
gi 1091153873 368 I 368
Cdd:cd16952    88 L 88
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 282-368 1.94e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 40.52  E-value: 1.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 282 IKQILIILLDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFYQAKDDHADSLSFGLGLSIAKAIV 361
Cdd:cd16975     5 LSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIAKNLV 84


                  ....*..
gi 1091153873 362 ERHKGRI 368
Cdd:cd16975    85 EKHGGSL 91
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 289-368 3.95e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 39.58  E-value: 3.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 289 LLDNAIRHSLS----KSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFYQAKD--DHadslsfGLGLSIAKAIVE 362
Cdd:cd16915     8 LIDNALDALAAtgapNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGqgER------GIGLALVRQSVE 81


                  ....*.
gi 1091153873 363 RHKGRI 368
Cdd:cd16915    82 RLGGSI 87
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 286-370 5.33e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 38.95  E-value: 5.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 286 LIILLDNAIRHSLSKSEIQFSLKQARrkAILTISNPSAIYSKEVMDNLFERFyQAKDDHADSLS--FGLGLSIAKAIVER 363
Cdd:cd16939     5 LDNLLRNALRYAHRTVRIALLVSGGR--LTLIVEDDGPGIPAAARERVFEPF-VRLDPSRDRATggFGLGLAIVHRVALW 81


                  ....*..
gi 1091153873 364 HKGRIRA 370
Cdd:cd16939    82 HGGHVEC 88
PRK10490 PRK10490
sensor protein KdpD; Provisional
 179-370 8.96e-04

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 41.56  E-value: 8.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 179 SHELKTPIAAIRANVQVLEQQIP--GNRYL-------DHVVSETKrmefLIEDLLNLSRLdeKRSKVNFKKLNLSVlcQE 249
Cdd:PRK10490  672 SHDLRTPLTVLFGQAEILTLDLAseGSPHArqaseirQQVLNTTR----LVNNLLDMARI--QSGGFNLRKEWLTL--EE 743

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 250 VL-LTYESLAYE-EEKCLNDTIEDDVWIV-GEESQIKQILIILLDNAIRHSLSKSEIqfSLKQARRKAILTIsnpsaiys 326
Cdd:PRK10490  744 VVgSALQMLEPGlSGHPINLSLPEPLTLIhVDGPLFERVLINLLENAVKYAGAQAEI--GIDAHVEGERLQL-------- 813

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1091153873 327 kEVMDN-----------LFERFYQAKDDHADSlSFGLGLSIAKAIVERHKGRIRA 370
Cdd:PRK10490  814 -DVWDNgpgippgqeqlIFDKFARGNKESAIP-GVGLGLAICRAIVEVHGGTIWA 866
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 281-368 9.69e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 38.67  E-value: 9.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 281 QIKQILIILLDNAIR----HSLSKSEIQFSLKQARRKAI-LTISNPSAIYSKEVMDNLFERFYQAKddhadSLSFGLGLS 355
Cdd:cd16944     4 QISQVLTNILKNAAEaiegRPSDVGEVRIRVEADQDGRIvLIVCDNGKGFPREMRHRATEPYVTTR-----PKGTGLGLA 78

                          90
                  ....*....|...
gi 1091153873 356 IAKAIVERHKGRI 368
Cdd:cd16944    79 IVKKIMEEHGGRI 91
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 282-368 3.41e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 36.99  E-value: 3.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 282 IKQILIILLDNA---IRHSL------SKSEIQFSLKQARRKAILTIS---NPSAIySKEVMDNLFERFYQAKDDHAdsls 349
Cdd:cd16918     1 LIQVFLNLVRNAaqaLAGSGgeiilrTRTQRQVTLGHPRHRLALRVSvidNGPGI-PPDLQDTIFYPMVSGRENGT---- 75

                          90
                  ....*....|....*....
gi 1091153873 350 fGLGLSIAKAIVERHKGRI 368
Cdd:cd16918    76 -GLGLAIAQNIVSQHGGVI 93
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 282-368 7.28e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 36.11  E-value: 7.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091153873 282 IKQILiillDNAIRHSLSKSEIQFSLKQARRKAILTISNPSAIYSKEVMDNLFERFYQAKDDHADSLSFGLGLSIAKAIV 361
Cdd:cd16948    10 IGQIV----SNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYLVKKLC 85


                  ....*....
gi 1091153873 362 ER--HKGRI 368
Cdd:cd16948    86 DKlgHKIDV 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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