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Conserved domains on  [gi|1091208001|gb|OHR35122|]
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glucosamine-6-phosphate deaminase [Corynebacterium sp. HMSC074C05]

Protein Classification

glucosamine-6-phosphate deaminase( domain architecture ID 10105361)

glucosamine-6-phosphate deaminase catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and an ammonium ion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 10-239 4.50e-121

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


:

Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 344.47  E-value: 4.50e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  10 AEVASIASDYLAYY--ANKGGNLGVATGSTPLATYRELIRRHRAGEVTFKDCSFFALDEYVGLPIEHEQSYYHVIHNEFS 87
Cdd:cd01399     1 EEMSEAAAELIAELirEKPPAVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMRENLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  88 DHVDVDPARVHIPDGLADDIGAACEDYERKIIEAGGIDIQLLGIGTNGHVGFNEPSSSFSSLTRIKTLHPQTVLDNARFF 167
Cdd:cd01399    81 DHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQANARFF 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1091208001 168 DSADDVPYHVVTQGLGTISRAGHLLLLATGTAKAHAIAASIEGPLSVSMPASVLQLHPRATVVIDQAAASEL 239
Cdd:cd01399   161 DGDEDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
 
Name Accession Description Interval E-value
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 10-239 4.50e-121

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 344.47  E-value: 4.50e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  10 AEVASIASDYLAYY--ANKGGNLGVATGSTPLATYRELIRRHRAGEVTFKDCSFFALDEYVGLPIEHEQSYYHVIHNEFS 87
Cdd:cd01399     1 EEMSEAAAELIAELirEKPPAVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMRENLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  88 DHVDVDPARVHIPDGLADDIGAACEDYERKIIEAGGIDIQLLGIGTNGHVGFNEPSSSFSSLTRIKTLHPQTVLDNARFF 167
Cdd:cd01399    81 DHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQANARFF 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1091208001 168 DSADDVPYHVVTQGLGTISRAGHLLLLATGTAKAHAIAASIEGPLSVSMPASVLQLHPRATVVIDQAAASEL 239
Cdd:cd01399   161 DGDEDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-253 2.45e-119

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 341.42  E-value: 2.45e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001   1 MEIIIVDSEAEVASIASDYLAYY-----ANKGGN--LGVATGSTPLATYRELIRRHRAGEVTFKDCSFFALDEYVGLPIE 73
Cdd:PRK00443    1 MRLIILKTAEEVGKWAARHIANRinaflPTKERPfvLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  74 HEQSYYHVIHNEFSDHVDVDPARVHIPDGLADDIGAACEDYERKIIEAGGIDIQLLGIGTNGHVGFNEPSSSFSSLTRIK 153
Cdd:PRK00443   81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001 154 TLHPQTVLDNARFFDSA-DDVPYHVVTQGLGTISRAGHLLLLATGTAKAHAIAASIEGPLSVSMPASVLQLHPRATVVID 232
Cdd:PRK00443  161 TLTEDTRIANSRFFDGDiEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                         250       260
                  ....*....|....*....|.
gi 1091208001 233 QAAASELKNKEYYEFTYAHKP 253
Cdd:PRK00443  241 EAAASELKVKTVKYFTELEAE 261
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-240 1.37e-111

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 321.34  E-value: 1.37e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001   1 MEIIIVDSEAEVASIASDYLAYY------ANKGGNLGVATGSTPLATYRELIRRHRAGEVTFKDCSFFALDEYVGLPIEH 74
Cdd:COG0363     2 MRVIIFPDAEELAAAAAERAAERiaeaiaEKGRAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVGLPPDH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  75 EQSYYHVIHNEFSDHVDVDPARVHIPDGLADDIGAACEDYERKIIEAGGIDIQLLGIGTNGHVGFNEPSSSFSSLT-RIK 153
Cdd:COG0363    82 PQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSETdRVV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001 154 TLHPQTVLDNARFFDSADDVPYHVVTQGLGTISRAGHLLLLATGTAKAHAIAASIEGPLSVSMPASVLQLHPRATVVIDQ 233
Cdd:COG0363   162 TLDESTRQANARFFGSIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVTWFLDE 241


                  ....*..
gi 1091208001 234 AAASELK 240
Cdd:COG0363   242 AAASLLT 248
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-248 4.95e-93

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 274.77  E-value: 4.95e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001   1 MEIIIVDSEAEVASIASDYLAYYAN-------KGGNLGVATGSTPLATYRELIRRHRAGEVTFKDCSFFALDEYVGLPIE 73
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINefkptaaRPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  74 HEQSYYHVIHNEFSDHVDVDPARVHIPDGLADDIGAACEDYERKIIEAGGIDIQLLGIGTNGHVGFNEPSSSFSSLTRIK 153
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001 154 TLHPQTVLDNARFFD-SADDVPYHVVTQGLGTISRAGHLLLLATGTAKAHAIAASIEGPLSVSMPASVLQLHPRATVVID 232
Cdd:TIGR00502 161 TLTEDTIQANSRFFEgDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*.
gi 1091208001 233 QAAASELKNKEYYEFT 248
Cdd:TIGR00502 241 ENATQELKVKTVEYFN 256
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
7-229 1.90e-18

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 81.13  E-value: 1.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001   7 DSEAEVASIASDYLA-----YYANKGG-NLGVATGSTPLATYRELIRRHRAGevtfkDCS---FFALDE-YVglPIEHEQ 76
Cdd:pfam01182   1 PDAEALAQALAERLAealeaALAERGRfTLALSGGSTPKPLYELLAAAPARL-----DWSrvhVFWGDErCV--PPDDPD 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  77 SYYHVIHNEFSDHVDVDPARVHIPDGLADDIGAACEDYERKIIEAGG------IDIQLLGIGTNGHVgfnepSSSFSSlt 150
Cdd:pfam01182  74 SNYGMAREALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPdlelpvFDLVLLGMGPDGHT-----ASLFPG-- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001 151 riktlHPQTVLDNARF---FDSADDVPYHvVTQGLGTISRAGHLLLLATGTAKAhAIAASIEGPLSVSMPASVLQLHPRA 227
Cdd:pfam01182 147 -----SPALEETDRLVvavTDSPKPPPER-ITLTLPVLNAARRVWFLVTGAGKA-DALRRALAGDPDPLPAALVRPGAGE 219


                  ..
gi 1091208001 228 TV 229
Cdd:pfam01182 220 TV 221
 
Name Accession Description Interval E-value
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 10-239 4.50e-121

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 344.47  E-value: 4.50e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  10 AEVASIASDYLAYY--ANKGGNLGVATGSTPLATYRELIRRHRAGEVTFKDCSFFALDEYVGLPIEHEQSYYHVIHNEFS 87
Cdd:cd01399     1 EEMSEAAAELIAELirEKPPAVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMRENLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  88 DHVDVDPARVHIPDGLADDIGAACEDYERKIIEAGGIDIQLLGIGTNGHVGFNEPSSSFSSLTRIKTLHPQTVLDNARFF 167
Cdd:cd01399    81 DHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQANARFF 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1091208001 168 DSADDVPYHVVTQGLGTISRAGHLLLLATGTAKAHAIAASIEGPLSVSMPASVLQLHPRATVVIDQAAASEL 239
Cdd:cd01399   161 DGDEDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-253 2.45e-119

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 341.42  E-value: 2.45e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001   1 MEIIIVDSEAEVASIASDYLAYY-----ANKGGN--LGVATGSTPLATYRELIRRHRAGEVTFKDCSFFALDEYVGLPIE 73
Cdd:PRK00443    1 MRLIILKTAEEVGKWAARHIANRinaflPTKERPfvLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  74 HEQSYYHVIHNEFSDHVDVDPARVHIPDGLADDIGAACEDYERKIIEAGGIDIQLLGIGTNGHVGFNEPSSSFSSLTRIK 153
Cdd:PRK00443   81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001 154 TLHPQTVLDNARFFDSA-DDVPYHVVTQGLGTISRAGHLLLLATGTAKAHAIAASIEGPLSVSMPASVLQLHPRATVVID 232
Cdd:PRK00443  161 TLTEDTRIANSRFFDGDiEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                         250       260
                  ....*....|....*....|.
gi 1091208001 233 QAAASELKNKEYYEFTYAHKP 253
Cdd:PRK00443  241 EAAASELKVKTVKYFTELEAE 261
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-240 1.37e-111

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 321.34  E-value: 1.37e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001   1 MEIIIVDSEAEVASIASDYLAYY------ANKGGNLGVATGSTPLATYRELIRRHRAGEVTFKDCSFFALDEYVGLPIEH 74
Cdd:COG0363     2 MRVIIFPDAEELAAAAAERAAERiaeaiaEKGRAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVGLPPDH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  75 EQSYYHVIHNEFSDHVDVDPARVHIPDGLADDIGAACEDYERKIIEAGGIDIQLLGIGTNGHVGFNEPSSSFSSLT-RIK 153
Cdd:COG0363    82 PQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSETdRVV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001 154 TLHPQTVLDNARFFDSADDVPYHVVTQGLGTISRAGHLLLLATGTAKAHAIAASIEGPLSVSMPASVLQLHPRATVVIDQ 233
Cdd:COG0363   162 TLDESTRQANARFFGSIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVTWFLDE 241


                  ....*..
gi 1091208001 234 AAASELK 240
Cdd:COG0363   242 AAASLLT 248
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-248 4.95e-93

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 274.77  E-value: 4.95e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001   1 MEIIIVDSEAEVASIASDYLAYYAN-------KGGNLGVATGSTPLATYRELIRRHRAGEVTFKDCSFFALDEYVGLPIE 73
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINefkptaaRPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  74 HEQSYYHVIHNEFSDHVDVDPARVHIPDGLADDIGAACEDYERKIIEAGGIDIQLLGIGTNGHVGFNEPSSSFSSLTRIK 153
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001 154 TLHPQTVLDNARFFD-SADDVPYHVVTQGLGTISRAGHLLLLATGTAKAHAIAASIEGPLSVSMPASVLQLHPRATVVID 232
Cdd:TIGR00502 161 TLTEDTIQANSRFFEgDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*.
gi 1091208001 233 QAAASELKNKEYYEFT 248
Cdd:TIGR00502 241 ENATQELKVKTVEYFN 256
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-244 2.33e-85

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 255.07  E-value: 2.33e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001   1 MEIIIVDSEAEVASIASDYLAYYANKGGN-------LGVATGSTPLATYRELIRRHRAGEVTFKDCSFFALDEYVGLPIE 73
Cdd:PTZ00285    1 MRIVISEDADAVADYTSNYIIKRINDFKPtsdrpfvLGLPTGSTPLPTYQELIRAYREGRVSFSNVVTFNMDEYVGLPRD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  74 HEQSYYHVIHNEFSDHVDVDPARVHIPDGLADDIGAACEDYERKIIEAGGIDIQLLGIGTNGHVGFNEPSSSFSSLTRIK 153
Cdd:PTZ00285   81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001 154 TLHPQTVLDNARFFDS-ADDVPYHVVTQGLGTISRAGHLLLLATGTAKAHAIAASIEGPLSVSMPASVLQLHPRATVVID 232
Cdd:PTZ00285  161 SLNQETIDANARFFGNdISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240

                         250
                  ....*....|..
gi 1091208001 233 QAAASELKNKEY 244
Cdd:PTZ00285  241 EDATLELKVKTT 252
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 24-239 2.82e-79

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 251.49  E-value: 2.82e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  24 ANKGGNLGVATGSTPLATYRELIRRHRAGEVTFKDCSFFALDEYVGLPIEHEQSYYHVIHNEFSDHVDVDPARVHIPDGL 103
Cdd:PRK02122   57 EGKPCVLGLATGSSPIGVYAELIRMHREEGLSFKNVITFNLDEYYPMQPDSLQSYHRFMKENLFDHVDIPPENIHIPDGT 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001 104 --ADDIGAACEDYERKIIEAGGIDIQLLGIGTNGHVGFNEPSSSFSSLTRIKTLHPQTVLDNARFFDSADDVPYHVVTQG 181
Cdd:PRK02122  137 ipKEEIDEYCRDYEEKIEAAGGIDFQLLGIGRTGHIGFNEPGSGRNSRTRLVTLDHITRRDAASDFFGEENVPRKAITMG 216

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1091208001 182 LGTISRAGHLLLLATGTAKAHAIAASIEGPLSVSMPASVLQLHPRATVVIDQAAASEL 239
Cdd:PRK02122  217 VGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASYLQEHPNATFVLDLAAASEL 274
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
1-241 4.23e-36

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 128.33  E-value: 4.23e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001   1 MEIIIVDSEAEVASIASDYL--AYYANKGGNLGVATGSTPLATYRELIRRHRaGEVTFKDCSFFALDEyvgLPIEHEQSY 78
Cdd:PRK12358    1 MKIIITKDYEEMSRVAAHHLlgYMSKTKRVNLAITAGSTPKGMYEYLITLVK-GKAWYDNVHYYNFDE---IPFRGKEGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  79 YHVIHNEFSDHVDvdpaRVHIPDGLADDIGAA-CEDYERKIIEAGGIDIQLLGIGTNGHVGFNEPS-SSFSSLTRIKTLH 156
Cdd:PRK12358   77 GVTITNLRNLFFT----PAGIKEENIHKLTIDnYREHDQKLARDGGLDLVVLGLGADGHFCGNLPGtTHFHDETVEVPIQ 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001 157 PQTV--LDNARFFDSADDVPYHVVTQGLGTISRAGHLLLLATGTAKAHAIAASIEGPLSVSMPASVLQLHPRATVVIDQA 234
Cdd:PRK12358  153 GEMVdiVAHGELGGDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHPNLTVILDEA 232


                  ....*..
gi 1091208001 235 AASELKN 241
Cdd:PRK12358  233 AAAELAL 239
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 1-232 3.34e-30

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 112.62  E-value: 3.34e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001   1 MEIIIVDSEAEVASIASDYL--AYYANKGGNLGVATGSTPLATYRELIRRHRAGEVTFKDCSFFALDEYVGLPIEHEQSY 78
Cdd:PRK09762    1 QTLQQVENYTALSERASEYLlaVIRSKPDAVICLATGATPLLTYHYLVEKIHQQQVDVSQLTFVKLDEWVDLPLTMPGTC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  79 YHVIHNEFSDHVDVDPARvHIPDGLADDIGAACEDYERKIIEAGGIDIQLLGIGTNGHVGFNEPSSSFSSLTRIKTLHPQ 158
Cdd:PRK09762   81 ETFLQQHIVQPLGLREDQ-LISFRSEEINETECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPGESLQPACHISQLDAR 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1091208001 159 TVLDNarFFDSADDVPYHVVTQGLGTISRAGHLLLLATGTAKAHAIAASIEGPLSVSMPASVLQLHPRATVVID 232
Cdd:PRK09762  160 TQQHE--MLKTAGRPVTRGITLGLKDILNAREVLLLVTGEGKQDATERFLTAKVSTAIPASFLWLHSNFICLID 231
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 12-231 1.42e-21

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 89.54  E-value: 1.42e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  12 VASIASDYLAyyanKGG--NLGVATGSTPLATYRELIRRHRageVTFKDCSFFALDE-YVglPIEHEQSYYHVIHNEFSD 88
Cdd:cd01400    11 IAEALAAAIA----KRGrfSLALSGGSTPKPLYELLAAAPA---LDWSKVHVFLGDErCV--PPDDPDSNYRLAREALLS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  89 HVDVDPARVH-IPDGLADDigAACEDYERKIIEAGG----IDIQLLGIGTNGHVgfnepSSSFSSltriktlHPQTVLDN 163
Cdd:cd01400    82 HVAIPAANIHpIPTELGPE--DAAAAYEKELRALFGgvppFDLVLLGMGPDGHT-----ASLFPG-------HPALLEET 147

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1091208001 164 ARFF---DSADDVPYHVVTQGLGTISRAGHLLLLATGTAKAHAIAASIEGPLSVSMPASVLQLHPRATVVI 231
Cdd:cd01400   148 DRLVvavTDSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRPGEVLWF 218
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 30-239 4.10e-19

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 83.19  E-value: 4.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  30 LGVATGSTPLATYRELIrrhrAGEVTFKDCSFFALDE-YVglPIEHEQSYYHVIHNEFSDHVDVDPARVHIPDGLADDIG 108
Cdd:TIGR01198  32 LALSGGRSPIALLEALA----AQPLDWSRIHLFLGDErYV--PLDHADSNTGLAREALLDRVAIPASNIHPMPTELSDIE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001 109 AACEDYERKI------IEAGGIDIQLLGIGTNGHVGfnepsssfssltrikTLHPQTVLDNAR-----FFDSADDVPYHV 177
Cdd:TIGR01198 106 EAAELYEQELaaafqpIVFPVFDLLLLGMGPDGHTA---------------SLFPHTPALQETerlvtVLTKSPKPPHER 170

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1091208001 178 VTQGLGTISRAGHLLLLATGTAKAHAIAASIE-GPLSVSMPASVLQLHPRATVVIDQAAASEL 239
Cdd:TIGR01198 171 ITLTLPAINAARKVFLLIAGEEKRNALAEALAvEAEPYPLPAAGVLHSGKTLWLLDYAAARKL 233
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 30-231 1.78e-18

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 80.09  E-value: 1.78e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  30 LGVATGSTPLATYRELIRRHRAGEvtFKDCSFFALDEYVGLPiEHEQSYYHVIHNEFSDHVDVDPARVHIPDGLADDIGA 109
Cdd:cd00458    24 IGLGTGSTPAYFYKLLGEKLKRGE--ISDIVGFPTDERYVPL-DSDQSNFRQAKLLAFEHDIIPASNVHYVDTSLPIEKA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001 110 ACEDYERKIIEAGGIDIQLLGIGtnghvgfnepsssfssltriktlhpqtvldnarffdsaddvpyhvvtqglgtiSRAG 189
Cdd:cd00458   101 CEKYEREILDQVDAIDLAVDGAG-----------------------------------------------------YRAG 127

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1091208001 190 HLLLLATGTAKAHAIAASIEGPLSVSMPASVLQLHPRATVVI 231
Cdd:cd00458   128 TVIVLVDGRKKVDYLCQNTEPGVIENGIFADIRGKEKDIVIV 169
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
7-229 1.90e-18

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 81.13  E-value: 1.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001   7 DSEAEVASIASDYLA-----YYANKGG-NLGVATGSTPLATYRELIRRHRAGevtfkDCS---FFALDE-YVglPIEHEQ 76
Cdd:pfam01182   1 PDAEALAQALAERLAealeaALAERGRfTLALSGGSTPKPLYELLAAAPARL-----DWSrvhVFWGDErCV--PPDDPD 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  77 SYYHVIHNEFSDHVDVDPARVHIPDGLADDIGAACEDYERKIIEAGG------IDIQLLGIGTNGHVgfnepSSSFSSlt 150
Cdd:pfam01182  74 SNYGMAREALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPdlelpvFDLVLLGMGPDGHT-----ASLFPG-- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001 151 riktlHPQTVLDNARF---FDSADDVPYHvVTQGLGTISRAGHLLLLATGTAKAhAIAASIEGPLSVSMPASVLQLHPRA 227
Cdd:pfam01182 147 -----SPALEETDRLVvavTDSPKPPPER-ITLTLPVLNAARRVWFLVTGAGKA-DALRRALAGDPDPLPAALVRPGAGE 219


                  ..
gi 1091208001 228 TV 229
Cdd:pfam01182 220 TV 221
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 74-246 5.38e-08

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 52.55  E-value: 5.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001  74 HEQSYYHVIHNEFSDHVDVDPARVHipdGLADDIGA--ACEDYE---RKIIEAGGI-----------DIQLLGIGTNGHV 137
Cdd:PLN02360   88 HADSNYKLAKDGLLSKVPVVPSHVY---SINDTVTAeeAATDYEfaiRQLVKTRTIgvsdisdcpkfDLILLGMGSDGHV 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091208001 138 gfnepSSSFSSltriktlHPQTVLDN--ARFFDSADDVPYHVVTQGLGTISRAGHLLLLATGTAKAHAIAASI----EGP 211
Cdd:PLN02360  165 -----ASLFPN-------HPALEEKDdwVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLAIddvtEGP 232

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1091208001 212 LSVSMPASVLQLHPRATV-VIDQAAASELKNKEYYE 246
Cdd:PLN02360  233 DAPSLPARMVQPTKGKLVwFLDKPAASKLDGFQFSE 268
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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