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Conserved domains on  [gi|1093027988|gb|OHW81087|]
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nitroreductase [Mycobacterium avium subsp. paratuberculosis]

Protein Classification

nitroreductase family deazaflavin-dependent oxidoreductase( domain architecture ID 10015413)

nitroreductase family deazaflavin-dependent oxidoreductase similar to Mycobacterium smegmatis F420(H2)-dependent reductase that catalyzes aflatoxin degradation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
hi_GC_TIGR00026 TIGR00026
deazaflavin-dependent oxidoreductase, nitroreductase family; This model represents a family of ...
 51-164 1.70e-47

deazaflavin-dependent oxidoreductase, nitroreductase family; This model represents a family of proteins found in paralogous families in the genera Mycobacterium and Streptomyces. Seven members are in Mycobacterium tuberculosis. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. [Unknown function, Enzymes of unknown specificity]


:

Pssm-ID: 211538  Cd Length: 113  Bit Score: 150.25  E-value: 1.70e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093027988  51 AGLATGIPVIMLTTTGAKSGEPRTVPVYGIPHPEGLALIASNFGGAKHPAWYFNLKAHPEATVTVGRDSWPATARLATPD 130
Cdd:TIGR00026   1 GGIARGLPVLLLTTTGRKTGKPRTTPVYYVRHDPGVLVVASNGGAPRHPDWYKNLKANPRVRVRVGGKVFVATARLVSGD 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1093027988 131 ERDQIWAKGVELYPGWRKYEVRaGDRHIEAFILS 164
Cdd:TIGR00026  81 ERAQLWAGVVRLYPRYQRYQSR-TDRPIPVVVLT 113
 
Name Accession Description Interval E-value
hi_GC_TIGR00026 TIGR00026
deazaflavin-dependent oxidoreductase, nitroreductase family; This model represents a family of ...
 51-164 1.70e-47

deazaflavin-dependent oxidoreductase, nitroreductase family; This model represents a family of proteins found in paralogous families in the genera Mycobacterium and Streptomyces. Seven members are in Mycobacterium tuberculosis. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 211538  Cd Length: 113  Bit Score: 150.25  E-value: 1.70e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093027988  51 AGLATGIPVIMLTTTGAKSGEPRTVPVYGIPHPEGLALIASNFGGAKHPAWYFNLKAHPEATVTVGRDSWPATARLATPD 130
Cdd:TIGR00026   1 GGIARGLPVLLLTTTGRKTGKPRTTPVYYVRHDPGVLVVASNGGAPRHPDWYKNLKANPRVRVRVGGKVFVATARLVSGD 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1093027988 131 ERDQIWAKGVELYPGWRKYEVRaGDRHIEAFILS 164
Cdd:TIGR00026  81 ERAQLWAGVVRLYPRYQRYQSR-TDRPIPVVVLT 113
F420H2_quin_red pfam04075
F420H(2)-dependent quinone reductase; This family of proteins is found in the genera ...
 56-163 7.54e-30

F420H(2)-dependent quinone reductase; This family of proteins is found in the genera Mycobacterium and Streptomyces. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. Rv1558 is an F420H(2)-dependent quinone reductase involved in oxidative stress protection.


Pssm-ID: 281995  Cd Length: 129  Bit Score: 105.61  E-value: 7.54e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093027988  56 GIPVIMLTTTGAKSGEPRTVPVYGIPHPEGLALIASNFGGAKHPAWYFNLKAHPEATVTVGRDSWPATARLATPDERDQI 135
Cdd:pfam04075  22 GVPVLLLTTTGRKTGQPRTTPLGGVRDGDSYLVVASKGGAPRHPGWYYNLKANPRVRVQIGGRWLDGTARLAPDDERARL 101

                          90       100
                  ....*....|....*....|....*...
gi 1093027988 136 WAKGVELYPGWRKYEVRAgDRHIEAFIL 163
Cdd:pfam04075 102 WQLPVLNSPGYAVYQSGT-DRPIPVVVL 128
 
Name Accession Description Interval E-value
hi_GC_TIGR00026 TIGR00026
deazaflavin-dependent oxidoreductase, nitroreductase family; This model represents a family of ...
 51-164 1.70e-47

deazaflavin-dependent oxidoreductase, nitroreductase family; This model represents a family of proteins found in paralogous families in the genera Mycobacterium and Streptomyces. Seven members are in Mycobacterium tuberculosis. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 211538  Cd Length: 113  Bit Score: 150.25  E-value: 1.70e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093027988  51 AGLATGIPVIMLTTTGAKSGEPRTVPVYGIPHPEGLALIASNFGGAKHPAWYFNLKAHPEATVTVGRDSWPATARLATPD 130
Cdd:TIGR00026   1 GGIARGLPVLLLTTTGRKTGKPRTTPVYYVRHDPGVLVVASNGGAPRHPDWYKNLKANPRVRVRVGGKVFVATARLVSGD 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1093027988 131 ERDQIWAKGVELYPGWRKYEVRaGDRHIEAFILS 164
Cdd:TIGR00026  81 ERAQLWAGVVRLYPRYQRYQSR-TDRPIPVVVLT 113
F420H2_quin_red pfam04075
F420H(2)-dependent quinone reductase; This family of proteins is found in the genera ...
 56-163 7.54e-30

F420H(2)-dependent quinone reductase; This family of proteins is found in the genera Mycobacterium and Streptomyces. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. Rv1558 is an F420H(2)-dependent quinone reductase involved in oxidative stress protection.


Pssm-ID: 281995  Cd Length: 129  Bit Score: 105.61  E-value: 7.54e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093027988  56 GIPVIMLTTTGAKSGEPRTVPVYGIPHPEGLALIASNFGGAKHPAWYFNLKAHPEATVTVGRDSWPATARLATPDERDQI 135
Cdd:pfam04075  22 GVPVLLLTTTGRKTGQPRTTPLGGVRDGDSYLVVASKGGAPRHPGWYYNLKANPRVRVQIGGRWLDGTARLAPDDERARL 101

                          90       100
                  ....*....|....*....|....*...
gi 1093027988 136 WAKGVELYPGWRKYEVRAgDRHIEAFIL 163
Cdd:pfam04075 102 WQLPVLNSPGYAVYQSGT-DRPIPVVVL 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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