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Conserved domains on  [gi|1109545717|gb|OJH55803|]
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hypothetical protein ATN81_00335 [Agrobacterium pusense]

Protein Classification

multiubiquitin domain-containing protein( domain architecture ID 10627976)

multiubiquitin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Prok-E2_E super family cl16898
Prokaryotic E2 family E; A member of the E2/UBC superfamily of proteins found in diverse ...
 128-241 4.65e-36

Prokaryotic E2 family E; A member of the E2/UBC superfamily of proteins found in diverse bacteria. Analysis of the active site residues suggest that members of this family are inactive as they lack the characteriztic catalytic residues of the E2 enzymes. They are usually fused to or in the neighborhood of a multi/poly ubiquitin domain protein. Other proteins of the ubiquitin modification pathway such as the E1 and JAB proteins are also found in its gene neighborhood along with a distinct predicted metal-binding protein.


The actual alignment was detected with superfamily member pfam14462:

Pssm-ID: 433971  Cd Length: 119  Bit Score: 123.99  E-value: 4.65e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109545717 128 DADMAFLEAYGHRFDIVRDGS-TWAILHDFPVPA-CFDHKSVSLAIRIEQGYPMTPLDMLYVYPKLSRIDGREIPQ-TQV 204
Cdd:pfam14462   1 EVDRRYLDERGLTWEEVVDGSqRGLIFKEFPLPEgKYNVAEADLLILIPPGYPDAPPDMFYCDPWLKLADGKRIPTaAEQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1109545717 205 EQPIEGRIFQRWSRHRSGAnlWVPGVDCLETHVFLIE 241
Cdd:pfam14462  81 NRAFDGRSWQRWSRHRNNE--WRPGVDGLWTMLKRIE 115
Multi_ubiq pfam14452
Multiubiquitin; A ubiquitin superfamily domain that is often present in multiple tandem copies ...
 43-106 5.13e-15

Multiubiquitin; A ubiquitin superfamily domain that is often present in multiple tandem copies in the same polypeptide. Members of this family are associated in gene neighborhoods, or on occasions fused to, bacterial homologs of components of ubiquitin-dependent modification system such as the E1, E2 and JAB metallopeptidase enzymes and a distinct metal-binding domain. The E2/UBC fold domain appears to be inactive. The JAB domain in these operons is usually fused to the E1 domain.


:

Pssm-ID: 433963  Cd Length: 69  Bit Score: 67.62  E-value: 5.13e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1109545717  43 YRFKINDTSFVWDKPHITGREVLILAGLTPPENYTLRVKLAGHKPQKIDLDEKIDLRHPGTEKF 106
Cdd:pfam14452   1 FTIIVNGRPFEVGDPTVTGAQIVALAGPDPPDDPVVLQTLGYGPDGEIRDGETVDLKAPGVEFF 64
 
Name Accession Description Interval E-value
Prok-E2_E pfam14462
Prokaryotic E2 family E; A member of the E2/UBC superfamily of proteins found in diverse ...
 128-241 4.65e-36

Prokaryotic E2 family E; A member of the E2/UBC superfamily of proteins found in diverse bacteria. Analysis of the active site residues suggest that members of this family are inactive as they lack the characteriztic catalytic residues of the E2 enzymes. They are usually fused to or in the neighborhood of a multi/poly ubiquitin domain protein. Other proteins of the ubiquitin modification pathway such as the E1 and JAB proteins are also found in its gene neighborhood along with a distinct predicted metal-binding protein.


Pssm-ID: 433971  Cd Length: 119  Bit Score: 123.99  E-value: 4.65e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109545717 128 DADMAFLEAYGHRFDIVRDGS-TWAILHDFPVPA-CFDHKSVSLAIRIEQGYPMTPLDMLYVYPKLSRIDGREIPQ-TQV 204
Cdd:pfam14462   1 EVDRRYLDERGLTWEEVVDGSqRGLIFKEFPLPEgKYNVAEADLLILIPPGYPDAPPDMFYCDPWLKLADGKRIPTaAEQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1109545717 205 EQPIEGRIFQRWSRHRSGAnlWVPGVDCLETHVFLIE 241
Cdd:pfam14462  81 NRAFDGRSWQRWSRHRNNE--WRPGVDGLWTMLKRIE 115
Multi_ubiq pfam14452
Multiubiquitin; A ubiquitin superfamily domain that is often present in multiple tandem copies ...
 43-106 5.13e-15

Multiubiquitin; A ubiquitin superfamily domain that is often present in multiple tandem copies in the same polypeptide. Members of this family are associated in gene neighborhoods, or on occasions fused to, bacterial homologs of components of ubiquitin-dependent modification system such as the E1, E2 and JAB metallopeptidase enzymes and a distinct metal-binding domain. The E2/UBC fold domain appears to be inactive. The JAB domain in these operons is usually fused to the E1 domain.


Pssm-ID: 433963  Cd Length: 69  Bit Score: 67.62  E-value: 5.13e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1109545717  43 YRFKINDTSFVWDKPHITGREVLILAGLTPPENYTLRVKLAGHKPQKIDLDEKIDLRHPGTEKF 106
Cdd:pfam14452   1 FTIIVNGRPFEVGDPTVTGAQIVALAGPDPPDDPVVLQTLGYGPDGEIRDGETVDLKAPGVEFF 64
 
Name Accession Description Interval E-value
Prok-E2_E pfam14462
Prokaryotic E2 family E; A member of the E2/UBC superfamily of proteins found in diverse ...
 128-241 4.65e-36

Prokaryotic E2 family E; A member of the E2/UBC superfamily of proteins found in diverse bacteria. Analysis of the active site residues suggest that members of this family are inactive as they lack the characteriztic catalytic residues of the E2 enzymes. They are usually fused to or in the neighborhood of a multi/poly ubiquitin domain protein. Other proteins of the ubiquitin modification pathway such as the E1 and JAB proteins are also found in its gene neighborhood along with a distinct predicted metal-binding protein.


Pssm-ID: 433971  Cd Length: 119  Bit Score: 123.99  E-value: 4.65e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109545717 128 DADMAFLEAYGHRFDIVRDGS-TWAILHDFPVPA-CFDHKSVSLAIRIEQGYPMTPLDMLYVYPKLSRIDGREIPQ-TQV 204
Cdd:pfam14462   1 EVDRRYLDERGLTWEEVVDGSqRGLIFKEFPLPEgKYNVAEADLLILIPPGYPDAPPDMFYCDPWLKLADGKRIPTaAEQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1109545717 205 EQPIEGRIFQRWSRHRSGAnlWVPGVDCLETHVFLIE 241
Cdd:pfam14462  81 NRAFDGRSWQRWSRHRNNE--WRPGVDGLWTMLKRIE 115
Multi_ubiq pfam14452
Multiubiquitin; A ubiquitin superfamily domain that is often present in multiple tandem copies ...
 43-106 5.13e-15

Multiubiquitin; A ubiquitin superfamily domain that is often present in multiple tandem copies in the same polypeptide. Members of this family are associated in gene neighborhoods, or on occasions fused to, bacterial homologs of components of ubiquitin-dependent modification system such as the E1, E2 and JAB metallopeptidase enzymes and a distinct metal-binding domain. The E2/UBC fold domain appears to be inactive. The JAB domain in these operons is usually fused to the E1 domain.


Pssm-ID: 433963  Cd Length: 69  Bit Score: 67.62  E-value: 5.13e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1109545717  43 YRFKINDTSFVWDKPHITGREVLILAGLTPPENYTLRVKLAGHKPQKIDLDEKIDLRHPGTEKF 106
Cdd:pfam14452   1 FTIIVNGRPFEVGDPTVTGAQIVALAGPDPPDDPVVLQTLGYGPDGEIRDGETVDLKAPGVEFF 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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