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Conserved domains on  [gi|1112414360|gb|OJO44280|]
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lyase [Escherichia coli]

Protein Classification

PRK09687 family protein( domain architecture ID 11484458)

PRK09687 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09687 PRK09687
putative lyase; Provisional
 1-280 7.49e-145

putative lyase; Provisional


:

Pssm-ID: 170047 [Multi-domain]  Cd Length: 280  Bit Score: 407.59  E-value: 7.49e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360   1 MSNTYQKRKASKEYGLYNQCKKLNDDELFRLLDDHNSLKRISSARVLQLRGGQDAVRLAIEFCSDKNYIRRDIGAFILGQ 80
Cdd:PRK09687    1 MSNSYKKRKASKEYSLYSQCKKLNDDELFRLLDDHNSLKRISSIRVLQLRGGQDVFRLAIELCSSKNPIERDIGADILSQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360  81 IKICKKCEDNVFNILNNMALNDKSACVRATAIESTAQRCKKNPIYSPKIVEQSQITAFDKSTNVRRATAFAISVINDKAT 160
Cdd:PRK09687   81 LGMAKRCQDNVFNILNNLALEDKSACVRASAINATGHRCKKNPLYSPKIVEQSQITAFDKSTNVRFAVAFALSVINDEAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360 161 IPLLINLLKDPNGDVRNWAAFAININKYDNSDIRDCFVEMLQDKNEEVRIEAIIGLSYRKDKRVLSVLCDELKKNTVYDD 240
Cdd:PRK09687  161 IPLLINLLKDPNGDVRNWAAFALNSNKYDNPDIREAFVAMLQDKNEEIRIEAIIGLALRKDKRVLSVLIKELKKGTVGDL 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1112414360 241 IIEAAGELGDKTLLPVLDTMLYKFDDNEIITSAIDKLKRS 280
Cdd:PRK09687  241 IIEAAGELGDKTLLPVLDTLLYKFDDNEIITKAIDKLKRS 280
 
Name Accession Description Interval E-value
PRK09687 PRK09687
putative lyase; Provisional
 1-280 7.49e-145

putative lyase; Provisional


Pssm-ID: 170047 [Multi-domain]  Cd Length: 280  Bit Score: 407.59  E-value: 7.49e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360   1 MSNTYQKRKASKEYGLYNQCKKLNDDELFRLLDDHNSLKRISSARVLQLRGGQDAVRLAIEFCSDKNYIRRDIGAFILGQ 80
Cdd:PRK09687    1 MSNSYKKRKASKEYSLYSQCKKLNDDELFRLLDDHNSLKRISSIRVLQLRGGQDVFRLAIELCSSKNPIERDIGADILSQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360  81 IKICKKCEDNVFNILNNMALNDKSACVRATAIESTAQRCKKNPIYSPKIVEQSQITAFDKSTNVRRATAFAISVINDKAT 160
Cdd:PRK09687   81 LGMAKRCQDNVFNILNNLALEDKSACVRASAINATGHRCKKNPLYSPKIVEQSQITAFDKSTNVRFAVAFALSVINDEAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360 161 IPLLINLLKDPNGDVRNWAAFAININKYDNSDIRDCFVEMLQDKNEEVRIEAIIGLSYRKDKRVLSVLCDELKKNTVYDD 240
Cdd:PRK09687  161 IPLLINLLKDPNGDVRNWAAFALNSNKYDNPDIREAFVAMLQDKNEEIRIEAIIGLALRKDKRVLSVLIKELKKGTVGDL 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1112414360 241 IIEAAGELGDKTLLPVLDTMLYKFDDNEIITSAIDKLKRS 280
Cdd:PRK09687  241 IIEAAGELGDKTLLPVLDTLLYKFDDNEIITKAIDKLKRS 280
HEAT COG1413
HEAT repeat [General function prediction only];
71-216 6.79e-17

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 75.44  E-value: 6.79e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360  71 RDIGAFILGQIKickkcEDNVFNILNNmALNDKSACVRATAIESTAQrckknpIYSPKIVEQSQITAFDKSTNVRRATAF 150
Cdd:COG1413     2 RRAAARALGRLG-----DPAAVPALIA-ALADEDPDVRAAAARALGR------LGDPRAVPALLEALKDPDPEVRAAAAE 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1112414360 151 AISVINDKATIPLLINLLKDPNGDVRNWAAFAinINKYDNSDIRDCFVEMLQDKNEEVRIEAIIGL 216
Cdd:COG1413    70 ALGRIGDPEAVPALIAALKDEDPEVRRAAAEA--LGRLGDPAAVPALLEALKDPDWEVRRAAARAL 133
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 139-217 1.26e-09

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 53.88  E-value: 1.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360 139 DKSTNVRRATAFAISVINDKATIPLLINLLKDPNGDVRNWAAFAinINKYDNSDIRDCFVEMLQDKN-EEVRIEAIIGLS 217
Cdd:pfam13646  11 DPDPEVRAAAIRALGRIGDPEAVPALLELLKDEDPAVRRAAAEA--LGKIGDPEALPALLELLRDDDdDVVRAAAAEALA 88
 
Name Accession Description Interval E-value
PRK09687 PRK09687
putative lyase; Provisional
 1-280 7.49e-145

putative lyase; Provisional


Pssm-ID: 170047 [Multi-domain]  Cd Length: 280  Bit Score: 407.59  E-value: 7.49e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360   1 MSNTYQKRKASKEYGLYNQCKKLNDDELFRLLDDHNSLKRISSARVLQLRGGQDAVRLAIEFCSDKNYIRRDIGAFILGQ 80
Cdd:PRK09687    1 MSNSYKKRKASKEYSLYSQCKKLNDDELFRLLDDHNSLKRISSIRVLQLRGGQDVFRLAIELCSSKNPIERDIGADILSQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360  81 IKICKKCEDNVFNILNNMALNDKSACVRATAIESTAQRCKKNPIYSPKIVEQSQITAFDKSTNVRRATAFAISVINDKAT 160
Cdd:PRK09687   81 LGMAKRCQDNVFNILNNLALEDKSACVRASAINATGHRCKKNPLYSPKIVEQSQITAFDKSTNVRFAVAFALSVINDEAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360 161 IPLLINLLKDPNGDVRNWAAFAININKYDNSDIRDCFVEMLQDKNEEVRIEAIIGLSYRKDKRVLSVLCDELKKNTVYDD 240
Cdd:PRK09687  161 IPLLINLLKDPNGDVRNWAAFALNSNKYDNPDIREAFVAMLQDKNEEIRIEAIIGLALRKDKRVLSVLIKELKKGTVGDL 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1112414360 241 IIEAAGELGDKTLLPVLDTMLYKFDDNEIITSAIDKLKRS 280
Cdd:PRK09687  241 IIEAAGELGDKTLLPVLDTLLYKFDDNEIITKAIDKLKRS 280
HEAT COG1413
HEAT repeat [General function prediction only];
71-216 6.79e-17

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 75.44  E-value: 6.79e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360  71 RDIGAFILGQIKickkcEDNVFNILNNmALNDKSACVRATAIESTAQrckknpIYSPKIVEQSQITAFDKSTNVRRATAF 150
Cdd:COG1413     2 RRAAARALGRLG-----DPAAVPALIA-ALADEDPDVRAAAARALGR------LGDPRAVPALLEALKDPDPEVRAAAAE 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1112414360 151 AISVINDKATIPLLINLLKDPNGDVRNWAAFAinINKYDNSDIRDCFVEMLQDKNEEVRIEAIIGL 216
Cdd:COG1413    70 ALGRIGDPEAVPALIAALKDEDPEVRRAAAEA--LGRLGDPAAVPALLEALKDPDWEVRRAAARAL 133
HEAT COG1413
HEAT repeat [General function prediction only];
144-261 1.03e-16

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 74.67  E-value: 1.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360 144 VRRATAFAISVINDKATIPLLINLLKDPNGDVRNWAAFAinINKYDNSDIRDCFVEMLQDKNEEVRIEAIIGLSYRKDKR 223
Cdd:COG1413     1 VRRAAARALGRLGDPAAVPALIAALADEDPDVRAAAARA--LGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPE 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1112414360 224 VLSVLCDELK--KNTVYDDIIEAAGELGDKTLLPVLDTML 261
Cdd:COG1413    79 AVPALIAALKdeDPEVRRAAAEALGRLGDPAAVPALLEAL 118
HEAT COG1413
HEAT repeat [General function prediction only];
107-233 3.51e-15

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 70.81  E-value: 3.51e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360 107 VRATAIESTAQRckKNPIYSPKIVEQSQitafDKSTNVRRATAFAISVINDKATIPLLINLLKDPNGDVRNWAAFAINin 186
Cdd:COG1413     1 VRRAAARALGRL--GDPAAVPALIAALA----DEDPDVRAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALG-- 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1112414360 187 KYDNSDIRDCFVEMLQDKNEEVRIEAIIGLSYRKDKRVLSVLCDELK 233
Cdd:COG1413    73 RIGDPEAVPALIAALKDEDPEVRRAAAEALGRLGDPAAVPALLEALK 119
HEAT COG1413
HEAT repeat [General function prediction only];
40-183 5.07e-15

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 70.04  E-value: 5.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360  40 RISSARVLQLRGGQDAVRLAIEFCSDKNYIRRDIGAFILGQIKickkcEDNVFNILNNmALNDKSACVRATAIESTAQrc 119
Cdd:COG1413     2 RRAAARALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLG-----DPRAVPALLE-ALKDPDPEVRAAAAEALGR-- 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1112414360 120 kknpIYSPKIVEQSQITAFDKSTNVRRATAFAISVINDKATIPLLINLLKDPNGDVRNWAAFAI 183
Cdd:COG1413    74 ----IGDPEAVPALIAALKDEDPEVRRAAAEALGRLGDPAAVPALLEALKDPDWEVRRAAARAL 133
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 139-217 1.26e-09

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 53.88  E-value: 1.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360 139 DKSTNVRRATAFAISVINDKATIPLLINLLKDPNGDVRNWAAFAinINKYDNSDIRDCFVEMLQDKN-EEVRIEAIIGLS 217
Cdd:pfam13646  11 DPDPEVRAAAIRALGRIGDPEAVPALLELLKDEDPAVRRAAAEA--LGKIGDPEALPALLELLRDDDdDVVRAAAAEALA 88
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 161-247 1.51e-09

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 53.88  E-value: 1.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360 161 IPLLINLL-KDPNGDVRNWAAFAINinKYDNSDIRDCFVEMLQDKNEEVRIEAIIGLSYRKDKRVLSVLCDELkKNTVYD 239
Cdd:pfam13646   1 LPALLQALlRDPDPEVRAAAIRALG--RIGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLELL-RDDDDD 77


                  ....*...
gi 1112414360 240 DIIEAAGE 247
Cdd:pfam13646  78 VVRAAAAE 85
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
102-219 8.84e-05

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 43.69  E-value: 8.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360 102 DKSACVRATAIESTAQRCKKNPIYSPKIVEQSqitafDKSTNVRRATAFAISVINDKATIPLLINLLKDPNGDVRNWAAF 181
Cdd:PRK13800  786 DPDPLVRAAALAALAELGCPPDDVAAATAALR-----ASAWQVRQGAARALAGAAADVAVPALVEALTDPHLDVRKAAVL 860

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1112414360 182 AInINKYDNSDIRDCFVEMLQDKNEEVRIEAIIGLSYR 219
Cdd:PRK13800  861 AL-TRWPGDPAARDALTTALTDSDADVRAYARRALAHA 897
RPN2 COG5116
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
 35-207 2.93e-04

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227446 [Multi-domain]  Cd Length: 926  Bit Score: 42.24  E-value: 2.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360  35 HNSLKR---ISSARVLQLRGgQDAVRLAIEFCSDKNYIRRDIGAFILGqIKICKKCEDNVFNILNNMALNDKSACVRATA 111
Cdd:COG5116   495 HERIKRglgIGFALILYGRQ-EMADDYINELLYDKDSILRYNGVFSLA-LAYVGTGNLGVVSTLLHYAVSDGNDDVRRAA 572

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360 112 IESTAQRCKKNPIYSPKIVEqsqitAFDKSTN--VRRATAFAISVI----NDKATIPLLINLLKDPNGDVRNWAAFA--- 182
Cdd:COG5116   573 VIALGFVCCDDRDLLVGTVE-----LLSESHNfhVRAGVAVALGIAcagtGDKVATDILEALMYDTNDFVRQSAMIAvgm 647

                         170       180       190
                  ....*....|....*....|....*....|
gi 1112414360 183 ININKYDN-----SDIRDCFVEMLQDKNEE 207
Cdd:COG5116   648 ILMQCNPElnpnvKRIIKKFNRVIVDKHES 677
HEAT COG1413
HEAT repeat [General function prediction only];
26-114 3.72e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 36.92  E-value: 3.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112414360  26 DELFRLLDDHNSLKRISSARVLQLRGGQDAVRLAIEFCSDKNYIRRDIGAFILGQIKickkcEDNVFNILNNmALNDKSA 105
Cdd:COG1413    50 PALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAALKDEDPEVRRAAAEALGRLG-----DPAAVPALLE-ALKDPDW 123


                  ....*....
gi 1112414360 106 CVRATAIES 114
Cdd:COG1413   124 EVRRAAARA 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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