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Conserved domains on  [gi|1113398453|gb|OJW61349|]
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GntR family transcriptional regulator [Sphingobacteriales bacterium 50-39]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
8-243 1.21e-71

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 218.58  E-value: 1.21e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453   8 DKKVPLHVQVEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVAEKKPlSTGLD 87
Cdd:COG2188     1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKI-EYPLS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453  88 HWYSFTQEMRERGIQVENISVKAEFVKAEAKVVRFFNIKEGKPVLKLAKLKGSDGEPIVYFESYFHPRIGV-VPEDNFSK 166
Cdd:COG2188    80 RLTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPgLLEEDLET 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1113398453 167 -PLYTMLEEKFGVLVVRSNENISAALAGP-MAKKLKISAGDPILIRERFVYDPGDRPIEYNIGYYRADKFTYNIDIKKT 243
Cdd:COG2188   160 gSLYELLEERYGLRITRAEQRIEAVLADAeEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
8-243 1.21e-71

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 218.58  E-value: 1.21e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453   8 DKKVPLHVQVEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVAEKKPlSTGLD 87
Cdd:COG2188     1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKI-EYPLS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453  88 HWYSFTQEMRERGIQVENISVKAEFVKAEAKVVRFFNIKEGKPVLKLAKLKGSDGEPIVYFESYFHPRIGV-VPEDNFSK 166
Cdd:COG2188    80 RLTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPgLLEEDLET 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1113398453 167 -PLYTMLEEKFGVLVVRSNENISAALAGP-MAKKLKISAGDPILIRERFVYDPGDRPIEYNIGYYRADKFTYNIDIKKT 243
Cdd:COG2188   160 gSLYELLEERYGLRITRAEQRIEAVLADAeEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 98-235 5.80e-29

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 106.14  E-value: 5.80e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453  98 ERGIQVENISVKAEFVKAEAKVVRFFNIKEGKPVLKLAKLKGSDGEPIVYFESYFHPRI--GVVPEDNFSKPLYTMLEEK 175
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELvpDLLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1113398453 176 FGVLVVRSNENISAALAGPM-AKKLKISAGDPILIRERFVYDPGDRPIEYNIGYYRADKFT 235
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEeAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 98-235 5.99e-29

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 106.22  E-value: 5.99e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453   98 ERGIQVENISVKAEFVKAEAKVVRFFNIKEGKPVLKLAKLKGSDGEPIVYFESYFHPRIG-VVPEDNFSKPLYTMLEEKF 176
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFpGLLEEDLSGSLYEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1113398453  177 G---VLVVRSNENISAALAGPM-AKKLKISAGDPILIRERFVYDPGDRPIEYNIGYYRADKFT 235
Cdd:smart00866  81 GlkiVRSTRAEQTITAVLADEEeAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
PRK11402 PRK11402
transcriptional regulator PhoB;
12-243 3.05e-24

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 96.83  E-value: 3.05e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453  12 PLHVQVEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVAEKKpLSTGLDHWYS 91
Cdd:PRK11402    9 LLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQK-VENALLTVSG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453  92 FTQEMRERGiQVENISVKAEFVKAEAKVVRFFNIKEGKPVLKLAKLKGSDGEPIVYFESYF----HPRIGVVPEDNFSkp 167
Cdd:PRK11402   88 FTDFGVSQG-KATKEKVIEQERVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIplsrYPDFDEIYVEGSS-- 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1113398453 168 LYTMLEEKFGVLVVRSNENISAALAG-PMAKKLKISAGDPILIRERFVYDPGDRPIEYNIGYYRADKFTYNIDIKKT 243
Cdd:PRK11402  165 TYQLFQERFDTRVVSDKKTIDIFAATrPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLTIDNKRH 241
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 12-77 4.18e-18

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 75.56  E-value: 4.18e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1113398453  12 PLHVQVEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVA 77
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
8-243 1.21e-71

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 218.58  E-value: 1.21e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453   8 DKKVPLHVQVEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVAEKKPlSTGLD 87
Cdd:COG2188     1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKI-EYPLS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453  88 HWYSFTQEMRERGIQVENISVKAEFVKAEAKVVRFFNIKEGKPVLKLAKLKGSDGEPIVYFESYFHPRIGV-VPEDNFSK 166
Cdd:COG2188    80 RLTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPgLLEEDLET 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1113398453 167 -PLYTMLEEKFGVLVVRSNENISAALAGP-MAKKLKISAGDPILIRERFVYDPGDRPIEYNIGYYRADKFTYNIDIKKT 243
Cdd:COG2188   160 gSLYELLEERYGLRITRAEQRIEAVLADAeEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 98-235 5.80e-29

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 106.14  E-value: 5.80e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453  98 ERGIQVENISVKAEFVKAEAKVVRFFNIKEGKPVLKLAKLKGSDGEPIVYFESYFHPRI--GVVPEDNFSKPLYTMLEEK 175
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELvpDLLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1113398453 176 FGVLVVRSNENISAALAGPM-AKKLKISAGDPILIRERFVYDPGDRPIEYNIGYYRADKFT 235
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEeAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 98-235 5.99e-29

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 106.22  E-value: 5.99e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453   98 ERGIQVENISVKAEFVKAEAKVVRFFNIKEGKPVLKLAKLKGSDGEPIVYFESYFHPRIG-VVPEDNFSKPLYTMLEEKF 176
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFpGLLEEDLSGSLYEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1113398453  177 G---VLVVRSNENISAALAGPM-AKKLKISAGDPILIRERFVYDPGDRPIEYNIGYYRADKFT 235
Cdd:smart00866  81 GlkiVRSTRAEQTITAVLADEEeAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
PRK11402 PRK11402
transcriptional regulator PhoB;
12-243 3.05e-24

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 96.83  E-value: 3.05e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453  12 PLHVQVEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVAEKKpLSTGLDHWYS 91
Cdd:PRK11402    9 LLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQK-VENALLTVSG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453  92 FTQEMRERGiQVENISVKAEFVKAEAKVVRFFNIKEGKPVLKLAKLKGSDGEPIVYFESYF----HPRIGVVPEDNFSkp 167
Cdd:PRK11402   88 FTDFGVSQG-KATKEKVIEQERVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIplsrYPDFDEIYVEGSS-- 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1113398453 168 LYTMLEEKFGVLVVRSNENISAALAG-PMAKKLKISAGDPILIRERFVYDPGDRPIEYNIGYYRADKFTYNIDIKKT 243
Cdd:PRK11402  165 TYQLFQERFDTRVVSDKKTIDIFAATrPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLTIDNKRH 241
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 16-232 1.20e-18

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 81.74  E-value: 1.20e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453  16 QVEELMRKliaspEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVAeKKPLSTGLDHWYSFTQE 95
Cdd:PRK10079   20 KLEQELRQ-----HYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVL-MRPYDYPLNAQARFSQN 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453  96 MRERGIQVENISVKAEFVKAEAKVVRFFNIKEGKPVLKLAKLKGSDGEPIVYFESYFhPRIGVVPE-DNF-SKPLYTMLE 173
Cdd:PRK10079   94 LLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYF-ADLTWWPTlQRFdSGSLHDFLR 172

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1113398453 174 EKFGVLVVRSNENISAALA-GPMAKKLKISAGDPIL-IRERFVYDPGDRPIEYNIGYYRAD 232
Cdd:PRK10079  173 EQLGIALRRSQTRISARRAqAKESQLLEIPNMSPLLcVRTLNHRDGESSPAEYSVSLTRAD 233
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 12-77 4.18e-18

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 75.56  E-value: 4.18e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1113398453  12 PLHVQVEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVA 77
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
9-78 8.57e-17

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 76.51  E-value: 8.57e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453   9 KKVPLHVQVEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVAE 78
Cdd:COG2186     4 RRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVRE 73
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
3-106 2.30e-15

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 69.82  E-value: 2.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453   3 LQIDHDKKVPLHVQVEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVAE---- 78
Cdd:COG1725     1 IRIDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEdare 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1113398453  79 ---KKPLSTGLDHWYSFTQEMRERGIQVENI 106
Cdd:COG1725    81 lleERREEFLEEALRELVAEARRLGLSLEEL 111
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 16-76 8.18e-15

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 66.87  E-value: 8.18e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1113398453  16 QVEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTV 76
Cdd:pfam00392   4 QVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-83 1.89e-14

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 71.78  E-value: 1.89e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453   1 MELQIDHDKKVPLHVQVEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVAEKK 80
Cdd:COG1167     1 MLIRLDRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARL 80


                  ...
gi 1113398453  81 PLS 83
Cdd:COG1167    81 PAP 83
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
17-76 2.95e-13

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 62.59  E-value: 2.95e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453   17 VEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTV 76
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
8-78 1.46e-12

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 64.56  E-value: 1.46e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1113398453   8 DKKVPLHVQVEELMRKLIASPEFRNGAFLpKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVAE 78
Cdd:COG1802     7 LRRESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP 76
PRK09764 PRK09764
GntR family transcriptional regulator;
12-235 5.28e-11

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 60.61  E-value: 5.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453  12 PLHVQVEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVAEKKpLSTGLDHWYS 91
Cdd:PRK09764    5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEER-VNYDIFQLTS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453  92 FTQEMRERGIQVENISVKAEFVKAEAKVVRFFNIKEGKPVLKLAKLKGSDGEPIVYFESYFhpRIGVVPEDNF---SKPL 168
Cdd:PRK09764   84 FDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWM--PLALFPDLTWqvmENSK 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453 169 YTMLEEKFGVLVVRSNENISAAL-AGPMAKKLKISAGDPILIRERFVYDPGDRPIEYNIGYYRAD--KFT 235
Cdd:PRK09764  162 YHFIEEVKKMVIDRSEQEIIPLMpTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDdyKFT 231
PRK14999 PRK14999
histidine utilization repressor; Provisional
 1-128 1.24e-10

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 59.56  E-value: 1.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453   1 MELQIDHDKKVPLHVQVEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVAEKK 80
Cdd:PRK14999    1 MYSSRSRSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1113398453  81 PLStGLDHWYSFTQEMRERGIQVENISVKAEFVKAEAKVVRFFNIKEG 128
Cdd:PRK14999   81 GQS-ALFEVRSIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNES 127
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 16-97 9.10e-10

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 57.08  E-value: 9.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453  16 QVEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVAEK----------KPLSTG 85
Cdd:PRK10421    6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRhetwseqnivQPLKTL 85

                          90
                  ....*....|....*
gi 1113398453  86 L--DHWYSF-TQEMR 97
Cdd:PRK10421   86 MadDPDYSFdILEAR 100
PRK10225 PRK10225
Uxu operon transcriptional regulator;
16-80 6.78e-09

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 54.64  E-value: 6.78e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1113398453  16 QVEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVAEKK 80
Cdd:PRK10225   13 EVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSS 77
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
17-79 3.82e-08

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 52.72  E-value: 3.82e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1113398453  17 VEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVAEK 79
Cdd:PRK09464   15 IEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSS 77
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
41-71 2.19e-04

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 37.97  E-value: 2.19e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1113398453   41 ELANRLGVSRNTIRQATNKLEYEGLLLRKKG 71
Cdd:smart00420  19 ELAELLGVSEMTIRRDLNKLEEQGLLTRVHG 49
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 17-65 4.53e-04

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 40.39  E-value: 4.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1113398453  17 VEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGL 65
Cdd:PRK03837   18 VEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGL 66
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 19-82 1.87e-03

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 38.87  E-value: 1.87e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1113398453  19 ELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVAEKKPL 82
Cdd:PRK15481   12 DSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRGSPSP 75
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
41-73 2.12e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 38.37  E-value: 2.12e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1113398453  41 ELANRLGVSRNTIRQATNKLEYEGLLLR---KKGVG 73
Cdd:COG2345    32 ELAEALGLTPNAVRRHLDALEEEGLVEReteRRGRG 67
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
41-71 3.58e-03

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 34.93  E-value: 3.58e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1113398453  41 ELANRLGVSRNTIRQATNKLEYEGLLLRKKG 71
Cdd:pfam08220  19 ELAELLGVSEMTIRRDLNELEEQGLLTRTHG 49
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 8-91 3.62e-03

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 37.82  E-value: 3.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113398453   8 DKKVPLHVQVEELMRKLIASPEFRNGAFLPKEVELANRLGVSRNTIRQATNKLEYEGLLLRKKGVGTTVAE--KKPLSTG 85
Cdd:PRK09990    3 DERRPIADVVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARlnRVQDASP 82


                  ....*.
gi 1113398453  86 LDHWYS 91
Cdd:PRK09990   83 LMHLFS 88
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
41-72 9.06e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 35.32  E-value: 9.06e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1113398453  41 ELANRLGVSRNTIRQATNKLEYEGLLLRKKGV 72
Cdd:COG3355    47 ELAEALDRSRSTVYRSLQKLLEAGLVEREKRN 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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