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Conserved domains on  [gi|1123201715|gb|OKW48710|]
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hypothetical protein AWP77_00005, partial [Escherichia coli]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
auto_Ag43 super family cl40321
Ag43/Cah family autotransporter adhesin; Members of this family, restricted to Escherichia ...
 1-156 8.30e-104

Ag43/Cah family autotransporter adhesin; Members of this family, restricted to Escherichia coli (including E. coli K-12) are the autotransporter adhesin Ag43 (antigen 43), also known as flu, or its calcium-binding homolog Cah, differing mostly in the central region. The C-terminal region forms an outer membrane beta-barrel autotransporter domain, which enables type V secretion (autotransport).


The actual alignment was detected with superfamily member NF033177:

Pssm-ID: 467980 [Multi-domain]  Cd Length: 948  Bit Score: 317.33  E-value: 8.30e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123201715   1 SLETGLPFSITDNLMLEPQLQYTWQGLSLDDGQDNAGYVKFGHGSAQHVRAGFRLGSHNDMTFGEGTSSRDTLRDSTKHR 80
Cdd:NF033177  779 SLETGLPFSITDNLMLEPQLQYTWQGLSLDDGQDNAGYVKFGHGSAQHVRAGFRLGSHNDMTFGEGTSSRDTLRDSAKHS 858

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1123201715  81 VSELPVNWWVQPSVIRTFSSRGDMSMGTAAAGSNMTFSPSRNGTSLDLQAGLEARVRENITLGVQAGYAHSVSGSS 156
Cdd:NF033177  859 VSELPVNWWVQPSVIRTFSSRGDMSMGTAAAGSNMTFSPSQNGTSLDLQAGLEARVRENITLGVQAGYAHSVSGSS 934
 
Name Accession Description Interval E-value
auto_Ag43 NF033177
Ag43/Cah family autotransporter adhesin; Members of this family, restricted to Escherichia ...
 1-156 8.30e-104

Ag43/Cah family autotransporter adhesin; Members of this family, restricted to Escherichia coli (including E. coli K-12) are the autotransporter adhesin Ag43 (antigen 43), also known as flu, or its calcium-binding homolog Cah, differing mostly in the central region. The C-terminal region forms an outer membrane beta-barrel autotransporter domain, which enables type V secretion (autotransport).


Pssm-ID: 467980 [Multi-domain]  Cd Length: 948  Bit Score: 317.33  E-value: 8.30e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123201715   1 SLETGLPFSITDNLMLEPQLQYTWQGLSLDDGQDNAGYVKFGHGSAQHVRAGFRLGSHNDMTFGEGTSSRDTLRDSTKHR 80
Cdd:NF033177  779 SLETGLPFSITDNLMLEPQLQYTWQGLSLDDGQDNAGYVKFGHGSAQHVRAGFRLGSHNDMTFGEGTSSRDTLRDSAKHS 858

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1123201715  81 VSELPVNWWVQPSVIRTFSSRGDMSMGTAAAGSNMTFSPSRNGTSLDLQAGLEARVRENITLGVQAGYAHSVSGSS 156
Cdd:NF033177  859 VSELPVNWWVQPSVIRTFSSRGDMSMGTAAAGSNMTFSPSQNGTSLDLQAGLEARVRENITLGVQAGYAHSVSGSS 934
AidA COG3468
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ...
 1-154 4.13e-12

Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442691 [Multi-domain]  Cd Length: 846  Bit Score: 62.66  E-value: 4.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123201715   1 SLETGLPFSITDNLMLEPQLQYTWQGLSLDDGQDNAG-YVKFGHGSAQHVRAGFRLGshndmtfGEGTSSRDTLrdstkh 79
Cdd:COG3468   701 SLEAGYPFKLGEGWSLEPQAQLIYQGVDFDDFTDSNGtRVSGDDGDSLQGRLGLRLG-------YEFHWDDGRA------ 767

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1123201715  80 rvselpVNWWVQPSVIRTFSSRGDMSMgtaaagSNMTFSPSRNGTSLDLQAGLEARVRENITLGVQAGYAHSVSG 154
Cdd:COG3468   768 ------LQPYLEANWLHEFLGDNSVTV------NGVSFSQDGSGTWGELGLGVTGQLNKNLSLYGDVGYQTGLDG 830
Autotransporter pfam03797
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 1-147 2.00e-10

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in. The N terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs.


Pssm-ID: 461054 [Multi-domain]  Cd Length: 255  Bit Score: 57.01  E-value: 2.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123201715   1 SLETGLPFSITDNLMLEPQLQYTWQGLSLDDGQDNAGY----VKFGHGSAQHVRAGFRLgshndmtfgegtssrdtlrdS 76
Cdd:pfam03797 121 SLEAGYRFALGGGWTLEPFAGLAYVRLRLDGFTESGGAaalsVDSQSYDSLTGRLGLRL--------------------S 180

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1123201715  77 TKHRVSELPVNWWVQPSVIRTFSSRGDMSM----GTAAAGSNMTFSPSRNGTSLDLQAGLEARVRENITLGVQAG 147
Cdd:pfam03797 181 YTFDLGGGTLTPYARLGWRHEFGDDDPVTTaafaGLSGAGSFTVAGADLARDSLELGAGLSAQLSDNLSLYANYD 255
Autotransporter smart00869
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 1-156 3.40e-07

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type IV pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C-terminus of the proteins it occurs in. The N-terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different peptidase is used and in some cases no cleavage occurs.


Pssm-ID: 214872 [Multi-domain]  Cd Length: 268  Bit Score: 47.95  E-value: 3.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123201715    1 SLETGLPFSITDNLMLEPQLQYTWQGLSLDDGQDNAGYVKFGHGSAQH-----VRAGFRLGSHNDMTFGEGtssrdtlrd 75
Cdd:smart00869 124 SLEAGYRFYLGGGLTLTPFAGLAYSRVRQDGFTESGGGAFGLSVDSQSldslsLPLGLRLEYRLALGDGAT--------- 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123201715   76 stkhrvselpVNWWVQPSVIRTFSSRGDMSMGTAAA--GSNMTFSPSRNGTSLDLQAGLEARVRENITLGVQAGYAHSVS 153
Cdd:smart00869 195 ----------LTPYLRLAYVHDFYDDNPVVTASLLGsgASFTTSGTDLDRNAAELGLGLSAKLSNGLSLSLNYDGEFGGS 264


                   ...
gi 1123201715  154 GSS 156
Cdd:smart00869 265 SRS 267
autotrans_barl TIGR01414
outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, ...
 1-148 2.85e-05

outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 273608 [Multi-domain]  Cd Length: 431  Bit Score: 42.76  E-value: 2.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123201715   1 SLETGLPFSITDN-LMLEPQLQYTWQGLSLDDGQDNAG-YVKFGHGSAQHVRAGFRLGSHNDMtfGEGTSSRDTLRdstk 78
Cdd:TIGR01414 287 SLEAGYRYNLGGNgWYVEPQAQLSYFGVSGDDYKESNGtRVLGGGGDSLQGRLGLRVGYQFDL--GTGRAVKPYLK---- 360

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123201715  79 hrvselpVNWwvqpsvIRTFSSrgdmsmGTAAAGSNMTFSPSRNGTSLDLQAGLEARVRENITLGVQAGY 148
Cdd:TIGR01414 361 -------ANV------LHEFKG------GTGVRVNGVTIRNDFSGTRAEYGVGVNAKIKDNLSLYADVDY 411
 
Name Accession Description Interval E-value
auto_Ag43 NF033177
Ag43/Cah family autotransporter adhesin; Members of this family, restricted to Escherichia ...
 1-156 8.30e-104

Ag43/Cah family autotransporter adhesin; Members of this family, restricted to Escherichia coli (including E. coli K-12) are the autotransporter adhesin Ag43 (antigen 43), also known as flu, or its calcium-binding homolog Cah, differing mostly in the central region. The C-terminal region forms an outer membrane beta-barrel autotransporter domain, which enables type V secretion (autotransport).


Pssm-ID: 467980 [Multi-domain]  Cd Length: 948  Bit Score: 317.33  E-value: 8.30e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123201715   1 SLETGLPFSITDNLMLEPQLQYTWQGLSLDDGQDNAGYVKFGHGSAQHVRAGFRLGSHNDMTFGEGTSSRDTLRDSTKHR 80
Cdd:NF033177  779 SLETGLPFSITDNLMLEPQLQYTWQGLSLDDGQDNAGYVKFGHGSAQHVRAGFRLGSHNDMTFGEGTSSRDTLRDSAKHS 858

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1123201715  81 VSELPVNWWVQPSVIRTFSSRGDMSMGTAAAGSNMTFSPSRNGTSLDLQAGLEARVRENITLGVQAGYAHSVSGSS 156
Cdd:NF033177  859 VSELPVNWWVQPSVIRTFSSRGDMSMGTAAAGSNMTFSPSQNGTSLDLQAGLEARVRENITLGVQAGYAHSVSGSS 934
AidA COG3468
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ...
 1-154 4.13e-12

Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442691 [Multi-domain]  Cd Length: 846  Bit Score: 62.66  E-value: 4.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123201715   1 SLETGLPFSITDNLMLEPQLQYTWQGLSLDDGQDNAG-YVKFGHGSAQHVRAGFRLGshndmtfGEGTSSRDTLrdstkh 79
Cdd:COG3468   701 SLEAGYPFKLGEGWSLEPQAQLIYQGVDFDDFTDSNGtRVSGDDGDSLQGRLGLRLG-------YEFHWDDGRA------ 767

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1123201715  80 rvselpVNWWVQPSVIRTFSSRGDMSMgtaaagSNMTFSPSRNGTSLDLQAGLEARVRENITLGVQAGYAHSVSG 154
Cdd:COG3468   768 ------LQPYLEANWLHEFLGDNSVTV------NGVSFSQDGSGTWGELGLGVTGQLNKNLSLYGDVGYQTGLDG 830
Autotransporter pfam03797
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 1-147 2.00e-10

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in. The N terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs.


Pssm-ID: 461054 [Multi-domain]  Cd Length: 255  Bit Score: 57.01  E-value: 2.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123201715   1 SLETGLPFSITDNLMLEPQLQYTWQGLSLDDGQDNAGY----VKFGHGSAQHVRAGFRLgshndmtfgegtssrdtlrdS 76
Cdd:pfam03797 121 SLEAGYRFALGGGWTLEPFAGLAYVRLRLDGFTESGGAaalsVDSQSYDSLTGRLGLRL--------------------S 180

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1123201715  77 TKHRVSELPVNWWVQPSVIRTFSSRGDMSM----GTAAAGSNMTFSPSRNGTSLDLQAGLEARVRENITLGVQAG 147
Cdd:pfam03797 181 YTFDLGGGTLTPYARLGWRHEFGDDDPVTTaafaGLSGAGSFTVAGADLARDSLELGAGLSAQLSDNLSLYANYD 255
Autotransporter smart00869
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 1-156 3.40e-07

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type IV pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C-terminus of the proteins it occurs in. The N-terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different peptidase is used and in some cases no cleavage occurs.


Pssm-ID: 214872 [Multi-domain]  Cd Length: 268  Bit Score: 47.95  E-value: 3.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123201715    1 SLETGLPFSITDNLMLEPQLQYTWQGLSLDDGQDNAGYVKFGHGSAQH-----VRAGFRLGSHNDMTFGEGtssrdtlrd 75
Cdd:smart00869 124 SLEAGYRFYLGGGLTLTPFAGLAYSRVRQDGFTESGGGAFGLSVDSQSldslsLPLGLRLEYRLALGDGAT--------- 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123201715   76 stkhrvselpVNWWVQPSVIRTFSSRGDMSMGTAAA--GSNMTFSPSRNGTSLDLQAGLEARVRENITLGVQAGYAHSVS 153
Cdd:smart00869 195 ----------LTPYLRLAYVHDFYDDNPVVTASLLGsgASFTTSGTDLDRNAAELGLGLSAKLSNGLSLSLNYDGEFGGS 264


                   ...
gi 1123201715  154 GSS 156
Cdd:smart00869 265 SRS 267
autotrans_barl TIGR01414
outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, ...
 1-148 2.85e-05

outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 273608 [Multi-domain]  Cd Length: 431  Bit Score: 42.76  E-value: 2.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123201715   1 SLETGLPFSITDN-LMLEPQLQYTWQGLSLDDGQDNAG-YVKFGHGSAQHVRAGFRLGSHNDMtfGEGTSSRDTLRdstk 78
Cdd:TIGR01414 287 SLEAGYRYNLGGNgWYVEPQAQLSYFGVSGDDYKESNGtRVLGGGGDSLQGRLGLRVGYQFDL--GTGRAVKPYLK---- 360

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123201715  79 hrvselpVNWwvqpsvIRTFSSrgdmsmGTAAAGSNMTFSPSRNGTSLDLQAGLEARVRENITLGVQAGY 148
Cdd:TIGR01414 361 -------ANV------LHEFKG------GTGVRVNGVTIRNDFSGTRAEYGVGVNAKIKDNLSLYADVDY 411
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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