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Conserved domains on  [gi|1125468613|gb|OLD92683|]
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protein TolR [Alphaproteobacteria bacterium 13_1_20CM_4_65_11]

Protein Classification

ExbD/TolR family protein( domain architecture ID 10021508)

ExbD/TolR family protein similar to Pseudomonas aeruginosa Tol-Pal system protein TolR, part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity

CATH:  3.30.420.270
Gene Ontology:  GO:0022857|GO:0005886|GO:0015031

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tolR TIGR02801
TolR protein; The model describes the inner membrane protein TolR, part of the TolR/TolQ ...
 23-144 2.04e-40

TolR protein; The model describes the inner membrane protein TolR, part of the TolR/TolQ complex that transduces energy from the proton-motive force, through TolA, to an outer membrane complex made up of TolB and Pal (peptidoglycan-associated lipoprotein). The complex is required to maintain outer membrane integrity, and defects may cause a defect in the import of some organic compounds in addition to the resulting morphologic. While several gene pairs homologous to talR and tolQ may be found in a single genome, but the scope of this model is set to favor finding only bone fide TolR, supported by operon structure as well as by score. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


:

Pssm-ID: 274306  Cd Length: 129  Bit Score: 132.35  E-value: 2.04e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125468613  23 PMSEINVTPLVDVMLVLLVIFMVTAPLLTVGVPVDLPQTQAPAINEP-KEPLVITLNREGVIYVQETTIE------TDAL 95
Cdd:TIGR02801   1 LMSEINVVPYVDVMLVLLIIFMVTAPLLTQGVKVDLPKSSAKPLQSKdKKPITVSVDADGKIYLNDNKIDkdeqldADEL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1125468613  96 VPKLQAITGANPDAVIYVRGDKDINYGRVLEVMSLVSSAGFRKVSLVAE 144
Cdd:TIGR02801  81 LAEIAAALAANPDTPVLIRADKTVPYGEVIKVMALLKQAGIEKVGLITE 129
 
Name Accession Description Interval E-value
tolR TIGR02801
TolR protein; The model describes the inner membrane protein TolR, part of the TolR/TolQ ...
 23-144 2.04e-40

TolR protein; The model describes the inner membrane protein TolR, part of the TolR/TolQ complex that transduces energy from the proton-motive force, through TolA, to an outer membrane complex made up of TolB and Pal (peptidoglycan-associated lipoprotein). The complex is required to maintain outer membrane integrity, and defects may cause a defect in the import of some organic compounds in addition to the resulting morphologic. While several gene pairs homologous to talR and tolQ may be found in a single genome, but the scope of this model is set to favor finding only bone fide TolR, supported by operon structure as well as by score. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274306  Cd Length: 129  Bit Score: 132.35  E-value: 2.04e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125468613  23 PMSEINVTPLVDVMLVLLVIFMVTAPLLTVGVPVDLPQTQAPAINEP-KEPLVITLNREGVIYVQETTIE------TDAL 95
Cdd:TIGR02801   1 LMSEINVVPYVDVMLVLLIIFMVTAPLLTQGVKVDLPKSSAKPLQSKdKKPITVSVDADGKIYLNDNKIDkdeqldADEL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1125468613  96 VPKLQAITGANPDAVIYVRGDKDINYGRVLEVMSLVSSAGFRKVSLVAE 144
Cdd:TIGR02801  81 LAEIAAALAANPDTPVLIRADKTVPYGEVIKVMALLKQAGIEKVGLITE 129
ExbD COG0848
Biopolymer transport protein ExbD [Intracellular trafficking, secretion, and vesicular ...
 14-148 9.92e-36

Biopolymer transport protein ExbD [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440609  Cd Length: 137  Bit Score: 120.77  E-value: 9.92e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125468613  14 GRSGRNRHRPMSEINVTPlvdvmlvllvIFMVTAPLLTV-GVPVDLPQTQAPAINEPKEPLVITLNREGVIYVQETTIET 92
Cdd:COG0848     2 ALSRRRRRREMAEINLTPlidvmfvlliFFMVTAPFLTPqGLKVDLPKASAAPPPKEPEPLTVSIDADGQIYLNGEPVDL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1125468613  93 DALVPKLQAITGANPDAVIYVRGDKDINYGRVLEVMSLVSSAGFRKVSLVAEAPKG 148
Cdd:COG0848    82 EELEARLKAALAANPDPEVVIRADKDVPYGDVVKVMDALRKAGITKVSLATEPKGG 137
ExbD pfam02472
Biopolymer transport protein ExbD/TolR; This group of proteins are membrane bound transport ...
 20-145 4.51e-25

Biopolymer transport protein ExbD/TolR; This group of proteins are membrane bound transport proteins essential for ferric ion uptake in bacteria. The Pfam family consists of ExbD, and TolR which are involved in TonB-dependent transport of various receptor bound substrates including colicins.


Pssm-ID: 426791  Cd Length: 128  Bit Score: 93.10  E-value: 4.51e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125468613  20 RHRPMSEINVTPLVDVMLVLLVIFMVTAPLLTVGV-PVDLPQTQAPAINEPKEPLVITLNREGVIYVQETTIETDALVPK 98
Cdd:pfam02472   1 KKEELAEINLTPLIDIMFVLLIFFLVTATLVPESVlKIDLPQSESGQNVVAKEVLTISVDADGSIYLDGKPVSLEELEAK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1125468613  99 LQAITGANPDAVIYVRGDKDINYGRVLEVMSLVSSAGFRKVSLVAEA 145
Cdd:pfam02472  81 LKELKKTDPDPTVVIRADKNVPYGDVVKVMDALKEAGIEKVSLATEP 127
PRK11267 PRK11267
biopolymer transport protein ExbD; Provisional
 24-144 1.11e-23

biopolymer transport protein ExbD; Provisional


Pssm-ID: 183064  Cd Length: 141  Bit Score: 90.18  E-value: 1.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125468613  24 MSEINVTPLVDVMLVLLVIFMVTAPLLTVGVPVDLPQTQAPAINEPKEPLVITLNREGVIYVQETTIETDALVPKLQAIT 103
Cdd:PRK11267   15 MHEINVTPFIDVMLVLLIIFMVAAPLATVDVKVNLPASTSTPQPRPEKPVYLSVKADNSMFIGNDPVTDETMITALDALT 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1125468613 104 GANPDAVIYVRGDKDINYGRVLEVMSLVSSAGFRKVSLVAE 144
Cdd:PRK11267   95 EGKKDTTIFFRADKTVDYETLMKVMDTLHQAGYLKIGLVGE 135
 
Name Accession Description Interval E-value
tolR TIGR02801
TolR protein; The model describes the inner membrane protein TolR, part of the TolR/TolQ ...
 23-144 2.04e-40

TolR protein; The model describes the inner membrane protein TolR, part of the TolR/TolQ complex that transduces energy from the proton-motive force, through TolA, to an outer membrane complex made up of TolB and Pal (peptidoglycan-associated lipoprotein). The complex is required to maintain outer membrane integrity, and defects may cause a defect in the import of some organic compounds in addition to the resulting morphologic. While several gene pairs homologous to talR and tolQ may be found in a single genome, but the scope of this model is set to favor finding only bone fide TolR, supported by operon structure as well as by score. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274306  Cd Length: 129  Bit Score: 132.35  E-value: 2.04e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125468613  23 PMSEINVTPLVDVMLVLLVIFMVTAPLLTVGVPVDLPQTQAPAINEP-KEPLVITLNREGVIYVQETTIE------TDAL 95
Cdd:TIGR02801   1 LMSEINVVPYVDVMLVLLIIFMVTAPLLTQGVKVDLPKSSAKPLQSKdKKPITVSVDADGKIYLNDNKIDkdeqldADEL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1125468613  96 VPKLQAITGANPDAVIYVRGDKDINYGRVLEVMSLVSSAGFRKVSLVAE 144
Cdd:TIGR02801  81 LAEIAAALAANPDTPVLIRADKTVPYGEVIKVMALLKQAGIEKVGLITE 129
ExbD COG0848
Biopolymer transport protein ExbD [Intracellular trafficking, secretion, and vesicular ...
 14-148 9.92e-36

Biopolymer transport protein ExbD [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440609  Cd Length: 137  Bit Score: 120.77  E-value: 9.92e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125468613  14 GRSGRNRHRPMSEINVTPlvdvmlvllvIFMVTAPLLTV-GVPVDLPQTQAPAINEPKEPLVITLNREGVIYVQETTIET 92
Cdd:COG0848     2 ALSRRRRRREMAEINLTPlidvmfvlliFFMVTAPFLTPqGLKVDLPKASAAPPPKEPEPLTVSIDADGQIYLNGEPVDL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1125468613  93 DALVPKLQAITGANPDAVIYVRGDKDINYGRVLEVMSLVSSAGFRKVSLVAEAPKG 148
Cdd:COG0848    82 EELEARLKAALAANPDPEVVIRADKDVPYGDVVKVMDALRKAGITKVSLATEPKGG 137
ExbD pfam02472
Biopolymer transport protein ExbD/TolR; This group of proteins are membrane bound transport ...
 20-145 4.51e-25

Biopolymer transport protein ExbD/TolR; This group of proteins are membrane bound transport proteins essential for ferric ion uptake in bacteria. The Pfam family consists of ExbD, and TolR which are involved in TonB-dependent transport of various receptor bound substrates including colicins.


Pssm-ID: 426791  Cd Length: 128  Bit Score: 93.10  E-value: 4.51e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125468613  20 RHRPMSEINVTPLVDVMLVLLVIFMVTAPLLTVGV-PVDLPQTQAPAINEPKEPLVITLNREGVIYVQETTIETDALVPK 98
Cdd:pfam02472   1 KKEELAEINLTPLIDIMFVLLIFFLVTATLVPESVlKIDLPQSESGQNVVAKEVLTISVDADGSIYLDGKPVSLEELEAK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1125468613  99 LQAITGANPDAVIYVRGDKDINYGRVLEVMSLVSSAGFRKVSLVAEA 145
Cdd:pfam02472  81 LKELKKTDPDPTVVIRADKNVPYGDVVKVMDALKEAGIEKVSLATEP 127
ExbD_1 TIGR02803
TonB system transport protein ExbD, group 1; Members of this family are Gram-negative ...
 24-144 4.44e-24

TonB system transport protein ExbD, group 1; Members of this family are Gram-negative bacterial inner membrane proteins, generally designated ExbD, related to the TolR family modeled by TIGRFAMs TIGR02801. Members always are encoded next to a protein designated ExbB (TIGR02797), related to the TolQ family modeled by TIGRFAMs TIGR02796. ExbD and ExbB together form a proton channel through which they can harness the proton-motive force to energize TonB, which in turn energizes TonB-dependent receptors in the outer membrane. TonB-dependent receptors with known specificity tend to import siderophores or vitamin B12. A TonB system and Tol-Pal system often will co-exist in a single bacterial genome.


Pssm-ID: 131850  Cd Length: 122  Bit Score: 90.66  E-value: 4.44e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125468613  24 MSEINVTPLVDVMLVLLVIFMVTAPLLTVGVPVDLPQTQAPAINEPKEPLVITLNREGVIYVQETTIETDALVPKLQAIT 103
Cdd:TIGR02803   1 NHEINVTPFIDVMLVLLIIFMVAAPLATVDVKVDLPASTAAPQPRPEKPVYVSVKADLSLFVGNDPVARETLGTALDALT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1125468613 104 GANPDAVIYVRGDKDINYGRVLEVMSLVSSAGFRKVSLVAE 144
Cdd:TIGR02803  81 EGDKDTTIFFRADKTVDYGDLMKVMNLLRQAGYLKIGLVGL 121
PRK11267 PRK11267
biopolymer transport protein ExbD; Provisional
 24-144 1.11e-23

biopolymer transport protein ExbD; Provisional


Pssm-ID: 183064  Cd Length: 141  Bit Score: 90.18  E-value: 1.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125468613  24 MSEINVTPLVDVMLVLLVIFMVTAPLLTVGVPVDLPQTQAPAINEPKEPLVITLNREGVIYVQETTIETDALVPKLQAIT 103
Cdd:PRK11267   15 MHEINVTPFIDVMLVLLIIFMVAAPLATVDVKVNLPASTSTPQPRPEKPVYLSVKADNSMFIGNDPVTDETMITALDALT 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1125468613 104 GANPDAVIYVRGDKDINYGRVLEVMSLVSSAGFRKVSLVAE 144
Cdd:PRK11267   95 EGKKDTTIFFRADKTVDYETLMKVMDTLHQAGYLKIGLVGE 135
PRK11024 PRK11024
colicin uptake protein TolR; Provisional
 15-144 1.47e-11

colicin uptake protein TolR; Provisional


Pssm-ID: 236824  Cd Length: 141  Bit Score: 58.56  E-value: 1.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125468613  15 RSGRNRHRPMSEINVTPLVDVMLVLLVIFMVTAPLLTVGVPVDLPQ-TQAPAI-NEPKEPLVITLNREG--VIYVQETTI 90
Cdd:PRK11024    3 ARGRGRRELKSEINIVPLLDVLLVLLLIFMATAPIITQSVEVDLPDaTESQAVsSNDNPPVIVEVSGVGqyTVVVDKDRM 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1125468613  91 E---TDALVPKLQAITGANPDAVIYVRGDKDINYGRVLEVMSLVSSAGFRKVSLVAE 144
Cdd:PRK11024   83 EqlpEEQVVAEAKSRFKANPKTVFLIGGAKDVPYDEIIKALNLLHSAGVKSVGLMTQ 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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