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Conserved domains on  [gi|1151269615|gb|OOP90699|]
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bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase [Helicobacter pylori]

Protein Classification

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase( domain architecture ID 11487152)

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase reversibly catalyzes oxidation of 5,10-methylene-THF to 5,10-methenyl-THF and hydrolysis of 5,10-methenyl-THF to 10-formyl-THF

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK14191 PRK14191
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 8-292 0e+00

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


:

Pssm-ID: 172679 [Multi-domain]  Cd Length: 285  Bit Score: 506.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615   8 VVLLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSL 87
Cdd:PRK14191    1 MVLLDGKALSYKIEKDLKNKIQILTAQTGKRPKLAVILVGKDPASQTYVNMKIKACERVGMDSDLHTLQENTTEAELLSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  88 IKDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDV 167
Cdd:PRK14191   81 IKDLNTDQNIDGILVQLPLPRHIDTKMVLEAIDPNKDVDGFHPLNIGKLCSQLDGFVPATPMGVMRLLKHYHIEIKGKDV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 168 AIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVG 247
Cdd:PRK14191  161 VIIGASNIVGKPLAMLMLNAGASVSVCHILTKDLSFYTQNADIVCVGVGKPDLIKASMVKKGAVVVDIGINRLNDGRLVG 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1151269615 248 DVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQRKGF 292
Cdd:PRK14191  241 DVDFENVAPKASFITPVPGGVGPMTIVSLLENTLIAAEKRQRKGF 285
 
Name Accession Description Interval E-value
PRK14191 PRK14191
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 8-292 0e+00

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172679 [Multi-domain]  Cd Length: 285  Bit Score: 506.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615   8 VVLLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSL 87
Cdd:PRK14191    1 MVLLDGKALSYKIEKDLKNKIQILTAQTGKRPKLAVILVGKDPASQTYVNMKIKACERVGMDSDLHTLQENTTEAELLSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  88 IKDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDV 167
Cdd:PRK14191   81 IKDLNTDQNIDGILVQLPLPRHIDTKMVLEAIDPNKDVDGFHPLNIGKLCSQLDGFVPATPMGVMRLLKHYHIEIKGKDV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 168 AIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVG 247
Cdd:PRK14191  161 VIIGASNIVGKPLAMLMLNAGASVSVCHILTKDLSFYTQNADIVCVGVGKPDLIKASMVKKGAVVVDIGINRLNDGRLVG 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1151269615 248 DVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQRKGF 292
Cdd:PRK14191  241 DVDFENVAPKASFITPVPGGVGPMTIVSLLENTLIAAEKRQRKGF 285
FolD COG0190
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...
 10-287 3.69e-157

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];


Pssm-ID: 439960 [Multi-domain]  Cd Length: 285  Bit Score: 439.45  E-value: 3.69e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIHTQtHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:COG0190     5 ILDGKAVAAEIREELKERVAALKAK-GITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELLALID 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAI 169
Cdd:COG0190    84 ELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGKHAVV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 170 IGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDV 249
Cdd:COG0190   164 VGRSNIVGKPLALLLLRRNATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGINRVEDGKLVGDV 243

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1151269615 250 DFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQ 287
Cdd:COG0190   244 DFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQ 281
THF_DHG_CYH_C pfam02882
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
129-288 3.75e-89

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;


Pssm-ID: 427036  Cd Length: 160  Bit Score: 262.40  E-value: 3.75e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 129 HPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNA 208
Cdd:pfam02882   1 HPYNLGRLVLGKPCFVPCTPRGIMELLKRYGIDLAGKNVVVVGRSNIVGKPLALLLLNANATVTVCHSKTKDLAEITREA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 209 DIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQ 288
Cdd:pfam02882  81 DIVVVAVGKPELIKADWIKPGAVVIDVGINRVGNGKLVGDVDFENVKEKASAITPVPGGVGPMTVAMLLQNTVEAAKRQL 160
NAD_bind_m-THF_DH_Cyclohyd cd01080
NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding ...
 121-285 8.30e-86

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding domain of the Methylene-Tetrahydrofolate Dehydrogenase/cyclohydrolase (m-THF DH/cyclohydrolase) bifunctional enzyme. Tetrahydrofolate is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofucntional DH, as well as bifunctional m-THF m-THF DHm-THF DHDH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains the bifunctional DH/cyclohydrolase. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains.


Pssm-ID: 133448  Cd Length: 168  Bit Score: 254.02  E-value: 8.30e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 121 PNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAIIGASNIIGKPLSMLMLNAGASVSVCHILTKD 200
Cdd:cd01080     1 PEKDVDGLHPVNLGRLALGRPGFIPCTPAGILELLKRYGIDLAGKKVVVVGRSNIVGKPLAALLLNRNATVTVCHSKTKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 201 ISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLND---GRIVGDVDFTNAQKVAGFITPVPKGVGPMTIVSLL 277
Cdd:cd01080    81 LKEHTKQADIVIVAVGKPGLVKGDMVKPGAVVIDVGINRVPDksgGKLVGDVDFESAKEKASAITPVPGGVGPMTVAMLM 160


                  ....*...
gi 1151269615 278 ENTLIAFE 285
Cdd:cd01080   161 KNTVEAAK 168
 
Name Accession Description Interval E-value
PRK14191 PRK14191
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 8-292 0e+00

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172679 [Multi-domain]  Cd Length: 285  Bit Score: 506.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615   8 VVLLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSL 87
Cdd:PRK14191    1 MVLLDGKALSYKIEKDLKNKIQILTAQTGKRPKLAVILVGKDPASQTYVNMKIKACERVGMDSDLHTLQENTTEAELLSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  88 IKDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDV 167
Cdd:PRK14191   81 IKDLNTDQNIDGILVQLPLPRHIDTKMVLEAIDPNKDVDGFHPLNIGKLCSQLDGFVPATPMGVMRLLKHYHIEIKGKDV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 168 AIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVG 247
Cdd:PRK14191  161 VIIGASNIVGKPLAMLMLNAGASVSVCHILTKDLSFYTQNADIVCVGVGKPDLIKASMVKKGAVVVDIGINRLNDGRLVG 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1151269615 248 DVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQRKGF 292
Cdd:PRK14191  241 DVDFENVAPKASFITPVPGGVGPMTIVSLLENTLIAAEKRQRKGF 285
FolD COG0190
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...
 10-287 3.69e-157

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];


Pssm-ID: 439960 [Multi-domain]  Cd Length: 285  Bit Score: 439.45  E-value: 3.69e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIHTQtHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:COG0190     5 ILDGKAVAAEIREELKERVAALKAK-GITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELLALID 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAI 169
Cdd:COG0190    84 ELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGKHAVV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 170 IGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDV 249
Cdd:COG0190   164 VGRSNIVGKPLALLLLRRNATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGINRVEDGKLVGDV 243

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1151269615 250 DFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQ 287
Cdd:COG0190   244 DFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQ 281
PRK14190 PRK14190
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 9-287 9.13e-128

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184560 [Multi-domain]  Cd Length: 284  Bit Score: 365.10  E-value: 9.13e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615   9 VLLDGQALAYDIEKDLKHKIQIIHTQThKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLI 88
Cdd:PRK14190    4 VIIDGKEVAKEKREQLKEEVVKLKEQG-IVPGLAVILVGDDPASHSYVRGKKKAAEKVGIYSELYEFPADITEEELLALI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  89 KDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVA 168
Cdd:PRK14190   83 DRLNADPRINGILVQLPLPKHIDEKAVIERISPEKDVDGFHPINVGRMMLGQDTFLPCTPHGILELLKEYNIDISGKHVV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 169 IIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGD 248
Cdd:PRK14190  163 VVGRSNIVGKPVGQLLLNENATVTYCHSKTKNLAELTKQADILIVAVGKPKLITADMVKEGAVVIDVGVNRLENGKLCGD 242

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1151269615 249 VDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQ 287
Cdd:PRK14190  243 VDFDNVKEKASYITPVPGGVGPMTITMLMHNTVELAKRA 281
PRK10792 PRK10792
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 10-286 1.60e-127

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 236760 [Multi-domain]  Cd Length: 285  Bit Score: 364.24  E-value: 1.60e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:PRK10792    5 IIDGKTIAQQVRSEVAQKVQARVAAGLRAPGLAVVLVGSDPASQVYVASKRKACEEVGFVSRSYDLPETTSEAELLALID 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCtQKESFL-PATPMGVMRLLEHYHIGIKGKDVA 168
Cdd:PRK10792   85 ELNADPTIDGILVQLPLPAHIDNVKVLERIHPDKDVDGFHPYNVGRLA-QRIPLLrPCTPRGIMTLLERYGIDTYGLNAV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 169 IIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGD 248
Cdd:PRK10792  164 VVGASNIVGRPMSLELLLAGCTVTVCHRFTKNLRHHVRNADLLVVAVGKPGFIPGEWIKPGAIVIDVGINRLEDGKLVGD 243

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1151269615 249 VDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEK 286
Cdd:PRK10792  244 VEFETAAERASWITPVPGGVGPMTVATLLENTLQACEE 281
PRK14189 PRK14189
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;
10-286 1.08e-118

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;


Pssm-ID: 184559 [Multi-domain]  Cd Length: 285  Bit Score: 342.05  E-value: 1.08e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIhTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:PRK14189    5 LIDGNALSKQLRAEAAQRAAAL-TARGHQPGLAVILVGDNPASQVYVRNKVKACEDNGFHSLKDRYPADLSEAELLARID 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAI 169
Cdd:PRK14189   84 ELNRDPKIHGILVQLPLPKHIDSHKVIEAIAPEKDVDGFHVANAGALMTGQPLFRPCTPYGVMKMLESIGIPLRGAHAVV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 170 IGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDV 249
Cdd:PRK14189  164 IGRSNIVGKPMAMLLLQAGATVTICHSKTRDLAAHTRQADIVVAAVGKRNVLTADMVKPGATVIDVGMNRDDAGKLCGDV 243

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1151269615 250 DFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEK 286
Cdd:PRK14189  244 DFAGVKEVAGYITPVPGGVGPMTITMLLVNTIEAAER 280
PRK14183 PRK14183
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 10-283 4.01e-115

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184555 [Multi-domain]  Cd Length: 281  Bit Score: 332.95  E-value: 4.01e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:PRK14183    3 ILDGKALSDKIKENVKKEVDELKLVKNIVPGLAVILVGDDPASHTYVKMKAKACDRVGIYSITHEMPSTISQKEILETIA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAI 169
Cdd:PRK14183   83 MMNNNPNIDGILVQLPLPKHIDTTKILEAIDPKKDVDGFHPYNVGRLVTGLDGFVPCTPLGVMELLEEYEIDVKGKDVCV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 170 IGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDV 249
Cdd:PRK14183  163 VGASNIVGKPMAALLLNANATVDICHIFTKDLKAHTKKADIVIVGVGKPNLITEDMVKEGAIVIDIGINRTEDGRLVGDV 242

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1151269615 250 DFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIA 283
Cdd:PRK14183  243 DFENVAKKCSYITPVPGGVGPMTIAMLLSNTLKA 276
PRK14166 PRK14166
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 8-281 6.90e-115

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172654 [Multi-domain]  Cd Length: 282  Bit Score: 332.38  E-value: 6.90e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615   8 VVLLDGQALAYDIEKDLKHKIQIIHTQTHKsPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSL 87
Cdd:PRK14166    1 MTLLDGKALSAKIKEELKEKNQFLKSKGIE-SCLAVILVGDNPASQTYVKSKAKACEECGIKSLVYHLNENTTQNELLAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  88 IKDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKES-FLPATPMGVMRLLEHYHIGIKGKD 166
Cdd:PRK14166   80 INTLNHDDSVHGILVQLPLPDHICKDLILESIISSKDVDGFHPINVGYLNLGLESgFLPCTPLGVMKLLKAYEIDLEGKD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 167 VAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIV 246
Cdd:PRK14166  160 AVIIGASNIVGRPMATMLLNAGATVSVCHIKTKDLSLYTRQADLIIVAAGCVNLLRSDMVKEGVIVVDVGINRLESGKIV 239

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1151269615 247 GDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTL 281
Cdd:PRK14166  240 GDVDFEEVSKKSSYITPVPGGVGPMTIAMLLENTV 274
PRK14176 PRK14176
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 10-286 1.65e-105

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184553 [Multi-domain]  Cd Length: 287  Bit Score: 308.66  E-value: 1.65e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:PRK14176   10 IIDGKALAKKIEAEVRSGVERLKSNRGITPGLATILVGDDPASKMYVRLKHKACERVGIRAEDQFLPADTTQEELLELID 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAI 169
Cdd:PRK14176   90 SLNKRKDVHGILLQLPLPKHLDPQEAMEAIDPAKDADGFHPYNMGKLMIGDEGLVPCTPHGVIRALEEYGVDIEGKNAVI 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 170 IGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGrIVGDV 249
Cdd:PRK14176  170 VGHSNVVGKPMAAMLLNRNATVSVCHVFTDDLKKYTLDADILVVATGVKHLIKADMVKEGAVIFDVGITKEEDK-VYGDV 248

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1151269615 250 DFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEK 286
Cdd:PRK14176  249 DFENVIKKASLITPVPGGVGPLTIAMLMKHVLMCAEK 285
PRK14186 PRK14186
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 10-287 3.54e-105

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 237636 [Multi-domain]  Cd Length: 297  Bit Score: 308.15  E-value: 3.54e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:PRK14186    4 ILDGKALAAEIEQRLQAQIESNLPKAGRPPGLAVLRVGDDPASAVYVRNKEKACARVGIASFGKHLPADTSQAEVEALIA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAI 169
Cdd:PRK14186   84 QLNQDERVDGILLQLPLPKHLDEVPLLHAIDPDKDADGLHPLNLGRLVKGEPGLRSCTPAGVMRLLRSQQIDIAGKKAVV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 170 IGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLND----GRI 245
Cdd:PRK14186  164 VGRSILVGKPLALMLLAANATVTIAHSRTQDLASITREADILVAAAGRPNLIGAEMVKPGAVVVDVGIHRLPSsdgkTRL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1151269615 246 VGDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQ 287
Cdd:PRK14186  244 CGDVDFEEVEPVAAAITPVPGGVGPMTVTMLLVNTVLSWQKR 285
PRK14188 PRK14188
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 10-283 3.41e-102

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184558 [Multi-domain]  Cd Length: 296  Bit Score: 300.34  E-value: 3.41e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:PRK14188    4 IIDGKAFAADVRATVAAEVARLKAAHGVTPGLAVVLVGEDPASQVYVRSKGKQTKEAGMASFEHKLPADTSQAELLALIA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAI 169
Cdd:PRK14188   84 RLNADPAIHGILVQLPLPKHLDSEAVIQAIDPEKDVDGLHVVNAGRLATGETALVPCTPLGCMMLLRRVHGDLSGLNAVV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 170 IGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHL-------ND 242
Cdd:PRK14188  164 IGRSNLVGKPMAQLLLAANATVTIAHSRTRDLPAVCRRADILVAAVGRPEMVKGDWIKPGATVIDVGINRIpapekgeGK 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1151269615 243 GRIVGDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIA 283
Cdd:PRK14188  244 TRLVGDVAFAEAAEVAGAITPVPGGVGPMTIACLLANTLTA 284
PRK14184 PRK14184
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 10-287 4.04e-101

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 237635 [Multi-domain]  Cd Length: 286  Bit Score: 297.46  E-value: 4.04e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:PRK14184    3 LLDGKATAATIREELKTEVAALTARHGRAPGLAVILVGEDPASQVYVRNKERACEDAGIVSEAFRLPADTTQEELEDLIA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAI 169
Cdd:PRK14184   83 ELNARPDIDGILLQLPLPKGLDSQRCLELIDPAKDVDGFHPENMGRLALGLPGFRPCTPAGVMTLLERYGLSPAGKKAVV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 170 IGASNIIGKPLSMLMLNAG----ASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGrI 245
Cdd:PRK14184  163 VGRSNIVGKPLALMLGAPGkfanATVTVCHSRTPDLAEECREADFLFVAIGRPRFVTADMVKPGAVVVDVGINRTDDG-L 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1151269615 246 VGDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQ 287
Cdd:PRK14184  242 VGDCDFEGLSDVASAITPVPGGVGPMTIAQLLVNTVQSWKER 283
PRK14173 PRK14173
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 38-291 4.17e-96

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184551 [Multi-domain]  Cd Length: 287  Bit Score: 284.80  E-value: 4.17e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  38 SPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIKDYNTDQNISGVLVQLPLPRHIDTKMILE 117
Cdd:PRK14173   29 VPHLRVVRLGEDPASVSYVRLKDRQAKALGLRSQVEVLPESTSQEELLELIARLNADPEVDGILVQLPLPPHIDFQRVLE 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 118 AIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAIIGASNIIGKPLSMLMLNAGASVSVCHIL 197
Cdd:PRK14173  109 AIDPLKDVDGFHPLNVGRLWMGGEALEPCTPAGVVRLLKHYGIPLAGKEVVVVGRSNIVGKPLAALLLREDATVTLAHSK 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 198 TKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHL--NDGR--IVGDVDFTNAQkVAGFITPVPKGVGPMTI 273
Cdd:PRK14173  189 TQDLPAVTRRADVLVVAVGRPHLITPEMVRPGAVVVDVGINRVggNGGRdiLTGDVHPEVAE-VAGALTPVPGGVGPMTV 267

                         250
                  ....*....|....*...
gi 1151269615 274 VSLLENTLIAFEKQQRKG 291
Cdd:PRK14173  268 AMLMANTVIAALRRRGGR 285
PRK14169 PRK14169
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 10-291 3.08e-95

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184550 [Multi-domain]  Cd Length: 282  Bit Score: 282.22  E-value: 3.08e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIhTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:PRK14169    3 RLDGRAVSKKILADLKQTVAKL-AQQDVTPTLAVVLVGSDPASEVYVRNKQRRAEDIGVRSLMFRLPEATTQADLLAKVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAI 169
Cdd:PRK14169   82 ELNHDPDVDAILVQLPLPAGLDEQAVIDAIDPDKDVDGFSPVSVGRLWANEPTVVASTPYGIMALLDAYDIDVAGKRVVI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 170 IGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDV 249
Cdd:PRK14169  162 VGRSNIVGRPLAGLMVNHDATVTIAHSKTRNLKQLTKEADILVVAVGVPHFIGADAVKPGAVVIDVGISRGADGKLLGDV 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1151269615 250 DFTNAQKVAGFITPVPKGVGPMTIVSLLENTlIAFEKQQRKG 291
Cdd:PRK14169  242 DEAAVAPIASAITPVPGGVGPMTIASLMAQT-VTLAKRRANG 282
PRK14171 PRK14171
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 10-285 2.80e-94

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172659 [Multi-domain]  Cd Length: 288  Bit Score: 280.30  E-value: 2.80e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:PRK14171    4 IIDGKALANEILADLKLEIQELKSQTNASPKLAIVLVGDNPASIIYVKNKIKNAHKIGIDTLLVNLSTTIHTNDLISKIN 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQ-KESFLPATPMGVMRLLEHYHIGIKGKDVA 168
Cdd:PRK14171   84 ELNLDNEISGIIVQLPLPSSIDKNKILSAVSPSKDIDGFHPLNVGYLHSGiSQGFIPCTALGCLAVIKKYEPNLTGKNVV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 169 IIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGD 248
Cdd:PRK14171  164 IIGRSNIVGKPLSALLLKENCSVTICHSKTHNLSSITSKADIVVAAIGSPLKLTAEYFNPESIVIDVGINRISGNKIIGD 243

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1151269615 249 VDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFE 285
Cdd:PRK14171  244 VDFENVKSKVKYITPVPGGIGPMTIAFLLKNTVKAFK 280
PRK14175 PRK14175
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 10-289 2.02e-93

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184552 [Multi-domain]  Cd Length: 286  Bit Score: 277.95  E-value: 2.02e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIHTQTHkSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:PRK14175    5 ILDGKQIAKDYRQGLQDQVEALKEKGF-TPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVLNELN 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAI 169
Cdd:PRK14175   84 RLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGKNAVV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 170 IGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDV 249
Cdd:PRK14175  164 IGRSHIVGQPVSKLLLQKNASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGNTPDENGKLKGDV 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1151269615 250 DFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAfEKQQR 289
Cdd:PRK14175  244 DYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLA-EKMRR 282
PRK14179 PRK14179
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;
10-287 1.14e-92

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;


Pssm-ID: 237634 [Multi-domain]  Cd Length: 284  Bit Score: 275.86  E-value: 1.14e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:PRK14179    4 IIDGKALAQKMQAELAEKVAKLKEEKGIVPGLVVILVGDNPASQVYVRNKERSALAAGFKSEVVRLPETISQEELLDLIE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAI 169
Cdd:PRK14179   84 RYNQDPTWHGILVQLPLPKHINEEKILLAIDPKKDVDGFHPMNTGHLWSGRPVMIPCTPAGIMEMFREYNVELEGKHAVV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 170 IGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDV 249
Cdd:PRK14179  164 IGRSNIVGKPMAQLLLDKNATVTLTHSRTRNLAEVARKADILVVAIGRGHFVTKEFVKEGAVVIDVGMNRDENGKLIGDV 243

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1151269615 250 DFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQ 287
Cdd:PRK14179  244 DFDEVAEVASYITPVPGGVGPMTITMLMEQTYQAALRS 281
PRK14174 PRK14174
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 8-286 2.67e-91

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172662 [Multi-domain]  Cd Length: 295  Bit Score: 272.85  E-value: 2.67e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615   8 VVLLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSL 87
Cdd:PRK14174    1 MLIIDGKKVSLDLKNELKTRVEAYRAKTGKVPGLTVIIVGEDPASQVYVRNKAKSCKEIGMNSTVIELPADTTEEHLLKK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  88 IKDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQK--ESFLPATPMGVMRLLEHYHIGIKGK 165
Cdd:PRK14174   81 IEDLNNDPDVHGILVQQPLPKQIDEFAVTLAIDPAKDVDGFHPENLGRLVMGHldKCFVSCTPYGILELLGRYNIETKGK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 166 DVAIIGASNIIGKPLSMLMLN----AGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLN 241
Cdd:PRK14174  161 HCVVVGRSNIVGKPMANLMLQklkeSNCTVTICHSATKDIPSYTRQADILIAAIGKARFITADMVKPGAVVIDVGINRIE 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1151269615 242 DG------RIVGDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEK 286
Cdd:PRK14174  241 DPstksgyRLVGDVDYEGVSAKASAITPVPGGVGPMTIAMLLKNTLQSFER 291
PRK14193 PRK14193
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 7-289 1.20e-89

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 237637 [Multi-domain]  Cd Length: 284  Bit Score: 268.03  E-value: 1.20e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615   7 GVVLLDGQALAYDIEKDLKHKIQIIHTQThKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLS 86
Cdd:PRK14193    2 TAIILDGKATADEIKADLAERVAALKEKG-ITPGLGTVLVGDDPGSQAYVRGKHRDCAEVGITSIRRDLPADATQEELNA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  87 LIKDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKD 166
Cdd:PRK14193   81 VIDELNADPACTGYIVQLPLPKHLDENAVLERIDPAKDADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRRYDVELAGAH 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 167 VAIIGASNIIGKPLSMLMLNAG--ASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGR 244
Cdd:PRK14193  161 VVVIGRGVTVGRPIGLLLTRRSenATVTLCHTGTRDLAAHTRRADIIVAAAGVAHLVTADMVKPGAAVLDVGVSRAGDGK 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1151269615 245 IVGDVDfTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQR 289
Cdd:PRK14193  241 LVGDVH-PDVWEVAGAVSPNPGGVGPMTRAFLLTNVVERAERRAG 284
PRK14192 PRK14192
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 10-287 1.74e-89

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184561 [Multi-domain]  Cd Length: 283  Bit Score: 267.87  E-value: 1.74e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:PRK14192    5 VLDGKALAKQIEEELSVRVEALKAKTGRTPILATILVGDDPASATYVRMKGNACRRVGMDSLKVELPQETTTEQLLAKIE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAI 169
Cdd:PRK14192   85 ELNANPDVHGILLQHPVPAQIDERACFDAISLAKDVDGVTCLGFGRMAMGEAAYGSATPAGIMRLLKAYNIELAGKHAVV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 170 IGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGInHLNDGRIVGDV 249
Cdd:PRK14192  165 VGRSAILGKPMAMMLLNANATVTICHSRTQNLPELVKQADIIVGAVGKPELIKKDWIKQGAVVVDAGF-HPRDGGGVGDI 243

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1151269615 250 DFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQ 287
Cdd:PRK14192  244 ELQGIEEIASAYTPVPGGVGPMTINTLIRQTVEAAEKA 281
THF_DHG_CYH_C pfam02882
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
129-288 3.75e-89

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;


Pssm-ID: 427036  Cd Length: 160  Bit Score: 262.40  E-value: 3.75e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 129 HPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNA 208
Cdd:pfam02882   1 HPYNLGRLVLGKPCFVPCTPRGIMELLKRYGIDLAGKNVVVVGRSNIVGKPLALLLLNANATVTVCHSKTKDLAEITREA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 209 DIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQ 288
Cdd:pfam02882  81 DIVVVAVGKPELIKADWIKPGAVVIDVGINRVGNGKLVGDVDFENVKEKASAITPVPGGVGPMTVAMLLQNTVEAAKRQL 160
PRK14180 PRK14180
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 8-289 5.12e-89

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172668 [Multi-domain]  Cd Length: 282  Bit Score: 266.51  E-value: 5.12e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615   8 VVLLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSL 87
Cdd:PRK14180    1 MILIDGKSLSKDLKERLATQVQEYKHHTAITPKLVAIIVGNDPASKTYVASKEKACAQVGIDSQVITLPEHTTESELLEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  88 IKDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPA-TPMGVMRLLEHYHIGIKGKD 166
Cdd:PRK14180   81 IDQLNNDSSVHAILVQLPLPAHINKNNVIYSIKPEKDVDGFHPTNVGRLQLRDKKCLEScTPKGIMTMLREYGIKTEGAY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 167 VAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLnDGRIV 246
Cdd:PRK14180  161 AVVVGASNVVGKPVSQLLLNAKATVTTCHRFTTDLKSHTTKADILIVAVGKPNFITADMVKEGAVVIDVGINHV-DGKIV 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1151269615 247 GDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQR 289
Cdd:PRK14180  240 GDVDFAAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQELNR 282
PRK14185 PRK14185
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 10-286 2.39e-88

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184556 [Multi-domain]  Cd Length: 293  Bit Score: 265.15  E-value: 2.39e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:PRK14185    3 LIDGKAISAQIKQEIAAEVAEIVAKGGKRPHLAAILVGHDGGSETYVANKVKACEECGFKSSLIRYESDVTEEELLAKVR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAI 169
Cdd:PRK14185   83 ELNQDDDVDGFIVQLPLPKHISEQKVIEAIDYRKDVDGFHPINVGRMSIGLPCFVSATPNGILELLKRYHIETSGKKCVV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 170 IGASNIIGKPLSMLMLNAG----ASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDG-- 243
Cdd:PRK14185  163 LGRSNIVGKPMAQLMMQKAypgdCTVTVCHSRSKNLKKECLEADIIIAALGQPEFVKADMVKEGAVVIDVGTTRVPDAtr 242

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1151269615 244 ----RIVGDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEK 286
Cdd:PRK14185  243 ksgfKLTGDVKFDEVAPKCSYITPVPGGVGPMTIVSLMKNTLLAGKK 289
PRK14194 PRK14194
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 10-288 4.88e-88

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172682 [Multi-domain]  Cd Length: 301  Bit Score: 264.79  E-value: 4.88e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIHTQTHKsPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:PRK14194    6 LIDGKAAAARVLAQVREDVRTLKAAGIE-PALAVILVGNDPASQVYVRNKILRAEEAGIRSLEHRLPADTSQARLLALIA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAI 169
Cdd:PRK14194   85 ELNADPSVNGILLQLPLPAHIDEARVLQAINPLKDVDGFHSENVGGLSQGRDVLTPCTPSGCLRLLEDTCGDLTGKHAVV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 170 IGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDG---RIV 246
Cdd:PRK14194  165 IGRSNIVGKPMAALLLQAHCSVTVVHSRSTDAKALCRQADIVVAAVGRPRLIDADWLKPGAVVIDVGINRIDDDgrsRLV 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1151269615 247 GDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQ 288
Cdd:PRK14194  245 GDVDFDSALPVVSAITPVPGGVGPMTIAFLMKNTVTAARLQA 286
PRK14167 PRK14167
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 10-288 5.30e-88

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184549 [Multi-domain]  Cd Length: 297  Bit Score: 264.33  E-value: 5.30e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIHTQTHKsPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:PRK14167    4 IIDGNAVAAQIRDDLTDAIETLEDAGVT-PGLATVLMSDDPASETYVSMKQRDCEEVGIEAIDVEIDPDAPAEELYDTID 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAI 169
Cdd:PRK14167   83 ELNADEDVHGILVQMPVPDHVDDREVLRRIDPAKDVDGFHPENVGRLVAGDARFKPCTPHGIQKLLAAAGVDTEGADVVV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 170 IGASNIIGKPLSMLMLNAG----ASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDG-- 243
Cdd:PRK14167  163 VGRSDIVGKPMANLLIQKAdggnATVTVCHSRTDDLAAKTRRADIVVAAAGVPELIDGSMLSEGATVIDVGINRVDADte 242

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1151269615 244 ---RIVGDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQ 288
Cdd:PRK14167  243 kgyELVGDVEFESAKEKASAITPVPGGVGPMTRAMLLYNTVKAASLQE 290
PLN02516 PLN02516
methylenetetrahydrofolate dehydrogenase (NADP+)
 10-281 1.09e-87

methylenetetrahydrofolate dehydrogenase (NADP+)


Pssm-ID: 178131 [Multi-domain]  Cd Length: 299  Bit Score: 263.68  E-value: 1.09e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGM-DFDLKtLQENITEAELLSLI 88
Cdd:PLN02516   11 IIDGKAIAKAIRSEIAEEVAQLSEKHGKVPGLAVVIVGSRKDSQTYVNMKRKACAEVGIkSFDVD-LPENISEAELISKV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  89 KDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQ--KESFLPATPMGVMRLLEHYHIGIKGKD 166
Cdd:PLN02516   90 HELNANPDVHGILVQLPLPKHINEEKILNEISLEKDVDGFHPLNIGKLAMKgrEPLFLPCTPKGCLELLSRSGIPIKGKK 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 167 VAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDG--- 243
Cdd:PLN02516  170 AVVVGRSNIVGLPVSLLLLKADATVTVVHSRTPDPESIVREADIVIAAAGQAMMIKGDWIKPGAAVIDVGTNAVSDPskk 249

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1151269615 244 ---RIVGDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTL 281
Cdd:PLN02516  250 sgyRLVGDVDFAEVSKVAGWITPVPGGVGPMTVAMLLKNTV 290
PRK14178 PRK14178
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 9-283 1.35e-86

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172666 [Multi-domain]  Cd Length: 279  Bit Score: 260.16  E-value: 1.35e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615   9 VLLDGQALAYDIEKDLKHKIQiihtQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLI 88
Cdd:PRK14178    1 MILDGKAVSEKRLELLKEEII----ESGLYPRLATVIVGDDPASQMYVRMKHRACERVGIGSVGIELPGDATTRTVLERI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  89 KDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVA 168
Cdd:PRK14178   77 RRLNEDPDINGILVQLPLPKGVDTERVIAAILPEKDVDGFHPLNLGRLVSGLPGFAPCTPNGIMTLLHEYKISIAGKRAV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 169 IIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNdGRIVGD 248
Cdd:PRK14178  157 VVGRSIDVGRPMAALLLNADATVTICHSKTENLKAELRQADILVSAAGKAGFITPDMVKPGATVIDVGINQVN-GKLCGD 235

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1151269615 249 VDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIA 283
Cdd:PRK14178  236 VDFDAVKEIAGAITPVPGGVGPMTIATLMENTFDA 270
PRK14177 PRK14177
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 9-287 1.65e-86

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172665 [Multi-domain]  Cd Length: 284  Bit Score: 260.29  E-value: 1.65e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615   9 VLLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLI 88
Cdd:PRK14177    4 ILLDGKKLSEKIRNEIRETIEERKTKNKRIPKLATILVGNNPASETYVSMKVKACHKVGMGSEMIRLKEQTTTEELLGVI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  89 KDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVA 168
Cdd:PRK14177   84 DKLNLDPNVDGILLQHPVPSQIDERAAFDRIALEKDVDGVTTLSFGKLSMGVETYLPCTPYGMVLLLKEYGIDVTGKNAV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 169 IIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNdgriVGD 248
Cdd:PRK14177  164 VVGRSPILGKPMAMLLTEMNATVTLCHSKTQNLPSIVRQADIIVGAVGKPEFIKADWISEGAVLLDAGYNPGN----VGD 239

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1151269615 249 VDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQ 287
Cdd:PRK14177  240 IEISKAKDKSSFYTPVPGGVGPMTIAVLLLQTLYSFKEH 278
NAD_bind_m-THF_DH_Cyclohyd cd01080
NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding ...
 121-285 8.30e-86

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding domain of the Methylene-Tetrahydrofolate Dehydrogenase/cyclohydrolase (m-THF DH/cyclohydrolase) bifunctional enzyme. Tetrahydrofolate is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofucntional DH, as well as bifunctional m-THF m-THF DHm-THF DHDH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains the bifunctional DH/cyclohydrolase. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains.


Pssm-ID: 133448  Cd Length: 168  Bit Score: 254.02  E-value: 8.30e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 121 PNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAIIGASNIIGKPLSMLMLNAGASVSVCHILTKD 200
Cdd:cd01080     1 PEKDVDGLHPVNLGRLALGRPGFIPCTPAGILELLKRYGIDLAGKKVVVVGRSNIVGKPLAALLLNRNATVTVCHSKTKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 201 ISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLND---GRIVGDVDFTNAQKVAGFITPVPKGVGPMTIVSLL 277
Cdd:cd01080    81 LKEHTKQADIVIVAVGKPGLVKGDMVKPGAVVIDVGINRVPDksgGKLVGDVDFESAKEKASAITPVPGGVGPMTVAMLM 160


                  ....*...
gi 1151269615 278 ENTLIAFE 285
Cdd:cd01080   161 KNTVEAAK 168
PLN02616 PLN02616
tetrahydrofolate dehydrogenase/cyclohydrolase, putative
 7-281 1.29e-85

tetrahydrofolate dehydrogenase/cyclohydrolase, putative


Pssm-ID: 215332 [Multi-domain]  Cd Length: 364  Bit Score: 260.71  E-value: 1.29e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615   7 GVVLLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLS 86
Cdd:PLN02616   72 GAKVIDGKAVAKKIRDEITIEVSRMKESIGVVPGLAVILVGDRKDSATYVRNKKKACDSVGINSFEVRLPEDSTEQEVLK 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  87 LIKDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKES--FLPATPMGVMRLLEHYHIGIKG 164
Cdd:PLN02616  152 FISGFNNDPSVHGILVQLPLPSHMDEQNILNAVSIEKDVDGFHPLNIGRLAMRGREplFVPCTPKGCIELLHRYNVEIKG 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 165 KDVAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDG- 243
Cdd:PLN02616  232 KRAVVIGRSNIVGMPAALLLQREDATVSIVHSRTKNPEEITREADIIISAVGQPNMVRGSWIKPGAVVIDVGINPVEDAs 311

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1151269615 244 -----RIVGDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTL 281
Cdd:PLN02616  312 sprgyRLVGDVCYEEACKVASAVTPVPGGVGPMTIAMLLSNTL 354
PRK14168 PRK14168
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 10-284 5.86e-83

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 237633 [Multi-domain]  Cd Length: 297  Bit Score: 251.72  E-value: 5.86e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:PRK14168    5 IIKGTEIREEILEEIRGEVAELKEKYGKVPGLVTILVGESPASLSYVTLKIKTAHRLGFHEIQDNQSVDITEEELLALID 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKE--SFLPATPMGVMRLLEHYHIGIKGKDV 167
Cdd:PRK14168   85 KYNNDDSIHGILVQLPLPKHINEKKVLNAIDPDKDVDGFHPVNVGRLMIGGDevKFLPCTPAGIQEMLVRSGVETSGAEV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 168 AIIGASNIIGKPLSMLMLNAG----ASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHL--- 240
Cdd:PRK14168  165 VVVGRSNIVGKPIANMMTQKGpganATVTIVHTRSKNLARHCQRADILIVAAGVPNLVKPEWIKPGATVIDVGVNRVgtn 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1151269615 241 ---NDGRIVGDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAF 284
Cdd:PRK14168  245 estGKAILSGDVDFDAVKEIAGKITPVPGGVGPMTIAMLMRNTLKSA 291
PRK14172 PRK14172
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 10-285 2.98e-82

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172660 [Multi-domain]  Cd Length: 278  Bit Score: 249.31  E-value: 2.98e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:PRK14172    4 IINGKEVALKIKEEIKNFVEERKENGLSIPKIASILVGNDGGSIYYMNNQEKVANSLGIDFKKIKLDESISEEDLINEIE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAI 169
Cdd:PRK14172   84 ELNKDNNVHGIMLQLPLPKHLDEKKITNKIDANKDIDCLTFISVGKFYKGEKCFLPCTPNSVITLIKSLNIDIEGKEVVV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 170 IGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLnDGRIVGDV 249
Cdd:PRK14172  164 IGRSNIVGKPVAQLLLNENATVTICHSKTKNLKEVCKKADILVVAIGRPKFIDEEYVKEGAIVIDVGTSSV-NGKITGDV 242

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1151269615 250 DFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFE 285
Cdd:PRK14172  243 NFDKVIDKASYITPVPGGVGSLTTTLLIKNVCEALK 278
PRK14182 PRK14182
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 8-281 2.63e-81

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172670 [Multi-domain]  Cd Length: 282  Bit Score: 246.86  E-value: 2.63e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615   8 VVLLDGQALAYDIEKDLKHKIQIIHTQThKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSL 87
Cdd:PRK14182    1 MNLIDGKQIAAKVKGEVATEVRALAARG-VQTGLTVVRVGDDPASAIYVRGKRKDCEEVGITSVEHHLPATTTQAELLAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  88 IKDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESF-LPATPMGVMRLLEHYHIGIKGKD 166
Cdd:PRK14182   80 IARLNADPAVHGILVQLPLPKHVDERAVLDAISPAKDADGFHPFNVGALSIGIAGVpRPCTPAGVMRMLDEARVDPKGKR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 167 VAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIV 246
Cdd:PRK14182  160 ALVVGRSNIVGKPMAMMLLERHATVTIAHSRTADLAGEVGRADILVAAIGKAELVKGAWVKEGAVVIDVGMNRLADGKLV 239

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1151269615 247 GDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTL 281
Cdd:PRK14182  240 GDVEFAAAAARASAITPVPGGVGPMTRAMLLVNTV 274
PLN02897 PLN02897
tetrahydrofolate dehydrogenase/cyclohydrolase, putative
 9-281 5.68e-81

tetrahydrofolate dehydrogenase/cyclohydrolase, putative


Pssm-ID: 178485 [Multi-domain]  Cd Length: 345  Bit Score: 248.34  E-value: 5.68e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615   9 VLLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLI 88
Cdd:PLN02897   57 VVIDGNVIAEEIRTKIASEVRKMKKAVGKVPGLAVVLVGQQRDSQTYVRNKIKACEETGIKSLLAELPEDCTEGQILSAL 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  89 KDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKES--FLPATPMGVMRLLEHYHIGIKGKD 166
Cdd:PLN02897  137 RKFNEDTSIHGILVQLPLPQHLDESKILNMVRLEKDVDGFHPLNVGNLAMRGREplFVSCTPKGCVELLIRSGVEIAGKN 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 167 VAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDG--- 243
Cdd:PLN02897  217 AVVIGRSNIVGLPMSLLLQRHDATVSTVHAFTKDPEQITRKADIVIAAAGIPNLVRGSWLKPGAVVIDVGTTPVEDSsce 296

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1151269615 244 ---RIVGDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTL 281
Cdd:PLN02897  297 fgyRLVGDVCYEEALGVASAITPVPGGVGPMTITMLLCNTL 337
PRK14187 PRK14187
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 9-283 1.24e-77

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172675 [Multi-domain]  Cd Length: 294  Bit Score: 237.80  E-value: 1.24e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615   9 VLLDGQALAYDIEKDLKHKIQIIHTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLI 88
Cdd:PRK14187    3 NIIDGKKIANDITEILATCIDDLKRQHNLFPCLIVILVGDDPASQLYVRNKQRKAEMLGLRSETILLPSTISESSLIEKI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  89 KDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCT--QKESFLPATPMGVMRLLEHYHIGIKGKD 166
Cdd:PRK14187   83 NELNNDDSVHGILVQLPVPNHIDKNLIINTIDPEKDVDGFHNENVGRLFTgqKKNCLIPCTPKGCLYLIKTITRNLSGSD 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 167 VAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDG--- 243
Cdd:PRK14187  163 AVVIGRSNIVGKPMACLLLGENCTVTTVHSATRDLADYCSKADILVAAVGIPNFVKYSWIKKGAIVIDVGINSIEEGgvk 242

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1151269615 244 RIVGDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIA 283
Cdd:PRK14187  243 KFVGDVDFAEVKKKASAITPVPGGVGPMTIAFLMVNTVIA 282
PRK14170 PRK14170
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 10-286 2.77e-77

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172658 [Multi-domain]  Cd Length: 284  Bit Score: 236.90  E-value: 2.77e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  10 LLDGQALAYDIEKDLKHKIQIIhTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIK 89
Cdd:PRK14170    4 IIDGKKLAKEIQEKVTREVAEL-VKEGKKPGLAVVLVGDNQASRTYVRNKQKRTEEAGMKSVLIELPENVTEEKLLSVVE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  90 DYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIGIKGKDVAI 169
Cdd:PRK14170   83 ELNEDKTIHGILVQLPLPEHISEEKVIDTISYDKDVDGFHPVNVGNLFIGKDSFVPCTPAGIIELIKSTGTQIEGKRAVV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 170 IGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDV 249
Cdd:PRK14170  163 IGRSNIVGKPVAQLLLNENATVTIAHSRTKDLPQVAKEADILVVATGLAKFVKKDYIKPGAIVIDVGMDRDENNKLCGDV 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1151269615 250 DFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEK 286
Cdd:PRK14170  243 DFDDVVEEAGFITPVPGGVGPMTITMLLANTLKAAKR 279
PRK14181 PRK14181
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 9-286 1.17e-75

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172669 [Multi-domain]  Cd Length: 287  Bit Score: 232.83  E-value: 1.17e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615   9 VLLDGQALAYDIEKDLKHKIqiihTQTHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLI 88
Cdd:PRK14181    1 MLLKGAPAAEHILATIKENI----SASSTAPGLAVVLIGNDPASEVYVGMKVKKATDLGMVSKAHRLPSDATLSDILKLI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  89 KDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCT-QKESFLPATPMGVMRLLEHYHIGIKGKDV 167
Cdd:PRK14181   77 HRLNNDPNIHGILVQLPLPKHLDAQAILQAISPDKDVDGLHPVNMGKLLLgETDGFIPCTPAGIIELLKYYEIPLHGRHV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 168 AIIGASNIIGKPLSMLML----NAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHL--N 241
Cdd:PRK14181  157 AIVGRSNIVGKPLAALLMqkhpDTNATVTLLHSQSENLTEILKTADIIIAAIGVPLFIKEEMIAEKAVIVDVGTSRVpaA 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1151269615 242 DGR---IVGDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEK 286
Cdd:PRK14181  237 NPKgyiLVGDVDFNNVVPKCRAITPVPGGVGPMTVAMLMRNTWESYLR 284
THF_DHG_CYH pfam00763
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;
11-126 1.33e-50

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;


Pssm-ID: 459930 [Multi-domain]  Cd Length: 115  Bit Score: 162.57  E-value: 1.33e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615  11 LDGQALAYDIEKDLKHKIQIIHTQtHKSPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITEAELLSLIKD 90
Cdd:pfam00763   1 IDGKAIAKKIREELKEEVAALKAG-GRKPGLAVILVGDDPASQVYVRNKKKACEEVGIESELIRLPEDTTEEELLALIDK 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1151269615  91 YNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVD 126
Cdd:pfam00763  80 LNADPSVHGILVQLPLPKHIDEEKVLEAIDPEKDVD 115
NAD_bind_m-THF_DH_Cyclohyd_like cd05212
NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and ...
 137-281 2.32e-21

NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NAD(P) binding domains of methylene-tetrahydrofolate dehydrogenase (m-THF DH) and m-THF DH/cyclohydrolase bifunctional enzymes (m-THF DH/cyclohydrolase). M-THF is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, mono-functional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express a monofunctional DH. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.


Pssm-ID: 133451  Cd Length: 140  Bit Score: 87.56  E-value: 2.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 137 CTQKesFLPATPMGVMRLLEHYHIGIKGKDVAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVG 216
Cdd:cd05212     3 CTPL--FVSPVAKAVKELLNKEGVRLDGKKVLVVGRSGIVGAPLQCLLQRDGATVYSCDWKTIQLQSKVHDADVVVVGSP 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1151269615 217 KPDLIKASMLKKGAVVVDIGINHLNDgrivgdvdfTNAQKVAGFITPVPKGVGPMTIVSLLENTL 281
Cdd:cd05212    81 KPEKVPTEWIKPGATVINCSPTKLSG---------DDVKESASLYVPMTGGVGKLTVAMRMQNMV 136
NAD_bind_m-THF_DH cd01079
NAD binding domain of methylene-tetrahydrofolate dehydrogenase; The NAD-binding domain of ...
 121-289 3.40e-10

NAD binding domain of methylene-tetrahydrofolate dehydrogenase; The NAD-binding domain of methylene-tetrahydrofolate dehydrogenase (m-THF DH). M-THF is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. M-THF DH is a component of an unusual monofunctional enzyme; in eukaryotes, m-THF DH is typically found as part of a multifunctional protein. NADP-dependent m-THF DHs in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofunctional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains only the monofunctional DHs from S. cerevisiae and certain bacteria. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.


Pssm-ID: 133447 [Multi-domain]  Cd Length: 197  Bit Score: 58.21  E-value: 3.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 121 PNKDVDGFHPLNIGKLC---------TQKESFLPATPMGVMRLLEH---------YHIGIKGKDVAIIGASNIIGKPLSM 182
Cdd:cd01079     1 PHKDVEGLSHKYIFNLYhnirfldpeNRKKSILPCTPLAIVKILEFlgiynkilpYGNRLYGKTITIINRSEVVGRPLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151269615 183 LMLNAGASV-SV----CHILTK------------DISFYTQN----ADIVCVGVGKPDL-IKASMLKKGAVVVDI-GINH 239
Cdd:cd01079    81 LLANDGARVySVdingIQVFTRgesirhekhhvtDEEAMTLDclsqSDVVITGVPSPNYkVPTELLKDGAICINFaSIKN 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1151269615 240 LNDgrivgdvdftNAQKVAGFITPVpkgVGPMTIVSLLENTLIAFEKQQR 289
Cdd:cd01079   161 FEP----------SVKEKASIYVPS---IGKVTIAMLLRNLLRLYHNQHH 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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