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Conserved domains on  [gi|1151294739|gb|OOQ13580|]
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phosphoethanolamine--lipid A transferase EptA [Helicobacter pylori]

Protein Classification

lipid A phosphoethanolamine transferase( domain architecture ID 11484384)

lipid A phosphoethanolamine transferase similar to EptA or EptB, which catalyzes the addition of a phosphoethanolamine moiety to lipid A or Kdo(2)-lipid A, respectively

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09598 PRK09598
phosphoethanolamine--lipid A transferase EptA;
1-521 0e+00

phosphoethanolamine--lipid A transferase EptA;


:

Pssm-ID: 236581 [Multi-domain]  Cd Length: 522  Bit Score: 889.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739   1 MASLFHLKFLKPLSCLQAGLLYSLIFGVLYHFPLFAYVYKESNQVSFIAMMVVVLFCVNGTLFLALGLISASLMRWSAIV 80
Cdd:PRK09598    1 MASLFHLKFLKPLSCLQAGLLYSLLNGVLYHFPLFAYVYKESNQVSFIAMLVVLLFCVNGLLFLLLGLLSRRLMRLSAIV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739  81 FSWLNSVAFYFISAYKVFLNKSMMGNVLNTNTHEVLGFLSVKLFVFIVVFGVLPGYIIYKIPIKNSSKKAPFLAILALVF 160
Cdd:PRK09598   81 FSLLNSIAFYFINTYKVFLNKSMMGNVLNTNTAESSGFLSVKLFIYIVVLGVLPGYIIYKIPLKNSSKKAPFAAILALVL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 161 IFIASALANAKNWLWFDKHAKFIGGLILPFAYSVNAFRVSALKFFAPTIKPL--PLFSPNHSNSFVVLVIGESARKHNYA 238
Cdd:PRK09598  161 IFLASAFANSKNWLWFDKHAKFLGGLILPWSYSVNTFRVSAHKFFAPTIKPLlpPLFSPNHSKSVVVLVIGESARKHNYA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 239 LYGYNKPTTPRLSKRLADNELTLFNATSCATYTTASLECILDSSFKN--NAYENLPTYLTKAGIKVFWYSANDGEKNVKV 316
Cdd:PRK09598  241 LYGYEKPTNPRLSKRLATHELTLFNATSCATYTTASLECILDSSFKNtsNAYENLPTYLTRAGIKVFWRSANDGEPNVKV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 317 TSYLKNYELIQKCSNCEaiAPYDESLLYNLPDLLKEHSNENVLLILHLAGSHGPNYDNKVPLNFRVFKPYCSSADLSSCS 396
Cdd:PRK09598  321 TSYLKNYELIQKCPNCE--APYDESLLYNLPELIKASSNENVLLILHLAGSHGPNYDNKYPLNFRVFKPVCSSVELSSCS 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 397 KESLINAYDNTIFYNDYLLDKIISMLKKAKQPALMIYLSDHGESLGEEAFYLHGIPKSIAPKEQYEIPFIVYANDLFKKE 476
Cdd:PRK09598  399 KESLINAYDNTIFYNDYLLDKIISMLKNLKQPALMIYLSDHGESLGEGAFYLHGIPKSIAPKEQYEIPFIVWASDSFKKQ 478

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 1151294739 477 HSIIQTQTPINQNVIFHSILGVFeDFKNPSVVYRPSLDLLKHKKE 521
Cdd:PRK09598  479 HSIIQTQTPINQNVIFHSVLGVF-DFKNPSAVYRPSLDLFKHKKE 522
 
Name Accession Description Interval E-value
PRK09598 PRK09598
phosphoethanolamine--lipid A transferase EptA;
1-521 0e+00

phosphoethanolamine--lipid A transferase EptA;


Pssm-ID: 236581 [Multi-domain]  Cd Length: 522  Bit Score: 889.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739   1 MASLFHLKFLKPLSCLQAGLLYSLIFGVLYHFPLFAYVYKESNQVSFIAMMVVVLFCVNGTLFLALGLISASLMRWSAIV 80
Cdd:PRK09598    1 MASLFHLKFLKPLSCLQAGLLYSLLNGVLYHFPLFAYVYKESNQVSFIAMLVVLLFCVNGLLFLLLGLLSRRLMRLSAIV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739  81 FSWLNSVAFYFISAYKVFLNKSMMGNVLNTNTHEVLGFLSVKLFVFIVVFGVLPGYIIYKIPIKNSSKKAPFLAILALVF 160
Cdd:PRK09598   81 FSLLNSIAFYFINTYKVFLNKSMMGNVLNTNTAESSGFLSVKLFIYIVVLGVLPGYIIYKIPLKNSSKKAPFAAILALVL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 161 IFIASALANAKNWLWFDKHAKFIGGLILPFAYSVNAFRVSALKFFAPTIKPL--PLFSPNHSNSFVVLVIGESARKHNYA 238
Cdd:PRK09598  161 IFLASAFANSKNWLWFDKHAKFLGGLILPWSYSVNTFRVSAHKFFAPTIKPLlpPLFSPNHSKSVVVLVIGESARKHNYA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 239 LYGYNKPTTPRLSKRLADNELTLFNATSCATYTTASLECILDSSFKN--NAYENLPTYLTKAGIKVFWYSANDGEKNVKV 316
Cdd:PRK09598  241 LYGYEKPTNPRLSKRLATHELTLFNATSCATYTTASLECILDSSFKNtsNAYENLPTYLTRAGIKVFWRSANDGEPNVKV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 317 TSYLKNYELIQKCSNCEaiAPYDESLLYNLPDLLKEHSNENVLLILHLAGSHGPNYDNKVPLNFRVFKPYCSSADLSSCS 396
Cdd:PRK09598  321 TSYLKNYELIQKCPNCE--APYDESLLYNLPELIKASSNENVLLILHLAGSHGPNYDNKYPLNFRVFKPVCSSVELSSCS 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 397 KESLINAYDNTIFYNDYLLDKIISMLKKAKQPALMIYLSDHGESLGEEAFYLHGIPKSIAPKEQYEIPFIVYANDLFKKE 476
Cdd:PRK09598  399 KESLINAYDNTIFYNDYLLDKIISMLKNLKQPALMIYLSDHGESLGEGAFYLHGIPKSIAPKEQYEIPFIVWASDSFKKQ 478

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 1151294739 477 HSIIQTQTPINQNVIFHSILGVFeDFKNPSVVYRPSLDLLKHKKE 521
Cdd:PRK09598  479 HSIIQTQTPINQNVIFHSVLGVF-DFKNPSAVYRPSLDLFKHKKE 522
OpgE COG2194
Phosphoethanolamine transferase for periplasmic glucans OpgE, AlkP superfamily [Cell wall ...
 8-517 1.90e-127

Phosphoethanolamine transferase for periplasmic glucans OpgE, AlkP superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441797 [Multi-domain]  Cd Length: 537  Bit Score: 382.28  E-value: 1.90e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739   8 KFLKPLSCLQAGLLYSLIFGVLYHFPLFAYVYK----ESNQVSFIAMMVVVLFCvngTLFLALGLISAS-LMRWSAIVFS 82
Cdd:COG2194     2 FLLPRLSPLKLILLLALYFALFLNLPFWGRLLAilplDGVNLLFLLSLPLLLLA---ALNLLLSLLAWRyLFKPLLILLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739  83 WLNSVAFYFISAYKVFLNKSMMGNVLNTNTHEVLGFLSVKLFVFIVVFGVLPGYIIYKIPIK-NSSKKAP---FLAILAL 158
Cdd:COG2194    79 LISAAASYFMDFYGVVIDYGMIQNVLETDPAEASELLSPKLILWLLLLGVLPALLLWRVRIRyRPLLRELgqrLALLLLA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 159 VFIFIASALANAKNWLWFDKHAKFIGGLILPFAYSVNAFRVSALKFFAPTIKPLPLF------SPNHSNSFVVLVIGESA 232
Cdd:COG2194   159 LLVIVLLALLFYKDYASFFRNHKELRYLINPSNFIYALGKYAKARYFAAPLPLQPLGadaklaAAGAKPTLVVLVVGETA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 233 RKHNYALYGYNKPTTPRLSKRladNELTLF-NATSCATYTTASLECIL-------DSSFKNNAYENLPTYLTKAGIKVFW 304
Cdd:COG2194   239 RADNFSLNGYARDTTPELAKE---KNLVSFrDVTSCGTATAVSVPCMFsrlgradYDPQRALNQENLLDVLQRAGVKVLW 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 305 YSANDGEKNVkvTSYLKNYELIQKCSN--CEAIAPYDESLLYNLPDLLKEHSNeNVLLILHLAGSHGPNYDNKVPLNFRV 382
Cdd:COG2194   316 RDNQSGCKGV--CDRVPTIDLTADNLPplCDGGECLDEVLLDGLDEALADLAG-DKLIVLHQMGSHGPAYYKRYPPEFRK 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 383 FKPYCSSADLSSCSKESLINAYDNTIFYNDYLLDKIISMLK--KAKQPALMIYLSDHGESLGEEAFYLHGIPKSIAPKEQ 460
Cdd:COG2194   393 FTPTCDTNDLQNCSREELVNAYDNTILYTDYVLSQVIDLLKakQDRYDTAMLYVSDHGESLGENGLYLHGTPYAIAPDEQ 472

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1151294739 461 YEIPFIVYANDLFKKEHSI------IQTQTPINQNVIFHSILGVFeDFKNPsvVYRPSLDLLK 517
Cdd:COG2194   473 THVPMIMWLSDGYAQRYGIdfaclkARADKPYSHDNLFHTLLGLL-DVRTS--VYDPELDILA 532
LptA cd16017
Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine ...
 224-499 4.80e-92

Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase; Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase catalyzes the modification of the lipid A headgroups by phosphoethanolamine (PEA) or 4-amino-arabinose residues. Lipopolysaccharides, also called endotoxins, protect bacterial pathogens from antimicrobial peptides and have roles in virulence. The PEA modified lipid A increases resistance to the cationic cyclic polypeptide antibiotic, polymyxin. Lipid A PEA transferases usually consist of a transmembrane domain anchoring the enzyme to the periplasmic face of the cytoplasmic membrane.


Pssm-ID: 293741 [Multi-domain]  Cd Length: 288  Bit Score: 282.59  E-value: 4.80e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 224 VVLVIGESARKHNYALYGYNKPTTPRLSKRlaDNELTLF-NATSCATYTTASLECILdsSFKN-------NAYENLPTYL 295
Cdd:cd16017     5 VVLVIGESARRDHMSLYGYPRDTTPFLSKL--KKNLIVFdNVISCGTSTAVSLPCML--SFANrenydraYYQENLIDLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 296 TKAGIKVFWYSANDGEKNV--KVTSYLKNYELIQKCSNCEAIAPYDESLLYNLPDLLKEhSNENVLLILHLAGSHGPnYD 373
Cdd:cd16017    81 KKAGYKTYWISNQGGCGGYdtRISAIAKIETVFTNKGSCNSSNCYDEALLPLLDEALAD-SSKKKLIVLHLMGSHGP-YY 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 374 NKVPLNFRVFKPYCSSaDLSSCSKESLINAYDNTIFYNDYLLDKIISMLKKAKQPALMIYLSDHGESLGEEAFYLHGIPK 453
Cdd:cd16017   159 DRYPEEFAKFTPDCDN-ELQSCSKEELINAYDNSILYTDYVLSQIIERLKKKDKDAALIYFSDHGESLGENGLYLHGAPY 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1151294739 454 siAPKEQYEIPFIVYANDLFKKEHSIIQTQ----TPINQNVIFHSILGVF 499
Cdd:cd16017   238 --APKEQYHVPFIIWSSDSYKQRYPVERLRankdRPFSHDNLFHTLLGLL 285
Sulfatase pfam00884
Sulfatase;
224-499 7.18e-57

Sulfatase;


Pssm-ID: 459979 [Multi-domain]  Cd Length: 298  Bit Score: 191.87  E-value: 7.18e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 224 VVLVIGESARKHNYALYGYNKPTTPRLSkRLADNELTLFNATSCATYTTASLECILDSSFKNNA-------------YEN 290
Cdd:pfam00884   3 VVLVLGESLRAPDLGLYGYPRPTTPFLD-RLAEEGLLFSNFYSGGTLTAPSRFALLTGLPPHNFgsyvstpvglprtEPS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 291 LPTYLTKAGIKV--------FWYSANDGEKN--VKVTSYLKNYELIQKCSNCEAIAP----YDESLLYNLPDLLKEHSnE 356
Cdd:pfam00884  82 LPDLLKRAGYNTgaigkwhlGWYNNQSPCNLgfDKFFGRNTGSDLYADPPDVPYNCSgggvSDEALLDEALEFLDNND-K 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 357 NVLLILHLAGSHGP-NYDNKVPLNFRVFKPycssadlSSCSKESLINAYDNTIFYNDYLLDKIISMLKKAKQ--PALMIY 433
Cdd:pfam00884 161 PFFLVLHTLGSHGPpYYPDRYPEKYATFKP-------SSCSEEQLLNSYDNTLLYTDDAIGRVLDKLEENGLldNTLVVY 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1151294739 434 LSDHGESLGEEAFYLHGIPKSIAPKEQYEIPFIVYANDLFKKEHsiiQTQTPINQNVIFHSILGVF 499
Cdd:pfam00884 234 TSDHGESLGEGGGYLHGGKYDNAPEGGYRVPLLIWSPGGKAKGQ---KSEALVSHVDLFPTILDLA 296
 
Name Accession Description Interval E-value
PRK09598 PRK09598
phosphoethanolamine--lipid A transferase EptA;
1-521 0e+00

phosphoethanolamine--lipid A transferase EptA;


Pssm-ID: 236581 [Multi-domain]  Cd Length: 522  Bit Score: 889.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739   1 MASLFHLKFLKPLSCLQAGLLYSLIFGVLYHFPLFAYVYKESNQVSFIAMMVVVLFCVNGTLFLALGLISASLMRWSAIV 80
Cdd:PRK09598    1 MASLFHLKFLKPLSCLQAGLLYSLLNGVLYHFPLFAYVYKESNQVSFIAMLVVLLFCVNGLLFLLLGLLSRRLMRLSAIV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739  81 FSWLNSVAFYFISAYKVFLNKSMMGNVLNTNTHEVLGFLSVKLFVFIVVFGVLPGYIIYKIPIKNSSKKAPFLAILALVF 160
Cdd:PRK09598   81 FSLLNSIAFYFINTYKVFLNKSMMGNVLNTNTAESSGFLSVKLFIYIVVLGVLPGYIIYKIPLKNSSKKAPFAAILALVL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 161 IFIASALANAKNWLWFDKHAKFIGGLILPFAYSVNAFRVSALKFFAPTIKPL--PLFSPNHSNSFVVLVIGESARKHNYA 238
Cdd:PRK09598  161 IFLASAFANSKNWLWFDKHAKFLGGLILPWSYSVNTFRVSAHKFFAPTIKPLlpPLFSPNHSKSVVVLVIGESARKHNYA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 239 LYGYNKPTTPRLSKRLADNELTLFNATSCATYTTASLECILDSSFKN--NAYENLPTYLTKAGIKVFWYSANDGEKNVKV 316
Cdd:PRK09598  241 LYGYEKPTNPRLSKRLATHELTLFNATSCATYTTASLECILDSSFKNtsNAYENLPTYLTRAGIKVFWRSANDGEPNVKV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 317 TSYLKNYELIQKCSNCEaiAPYDESLLYNLPDLLKEHSNENVLLILHLAGSHGPNYDNKVPLNFRVFKPYCSSADLSSCS 396
Cdd:PRK09598  321 TSYLKNYELIQKCPNCE--APYDESLLYNLPELIKASSNENVLLILHLAGSHGPNYDNKYPLNFRVFKPVCSSVELSSCS 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 397 KESLINAYDNTIFYNDYLLDKIISMLKKAKQPALMIYLSDHGESLGEEAFYLHGIPKSIAPKEQYEIPFIVYANDLFKKE 476
Cdd:PRK09598  399 KESLINAYDNTIFYNDYLLDKIISMLKNLKQPALMIYLSDHGESLGEGAFYLHGIPKSIAPKEQYEIPFIVWASDSFKKQ 478

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 1151294739 477 HSIIQTQTPINQNVIFHSILGVFeDFKNPSVVYRPSLDLLKHKKE 521
Cdd:PRK09598  479 HSIIQTQTPINQNVIFHSVLGVF-DFKNPSAVYRPSLDLFKHKKE 522
OpgE COG2194
Phosphoethanolamine transferase for periplasmic glucans OpgE, AlkP superfamily [Cell wall ...
 8-517 1.90e-127

Phosphoethanolamine transferase for periplasmic glucans OpgE, AlkP superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441797 [Multi-domain]  Cd Length: 537  Bit Score: 382.28  E-value: 1.90e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739   8 KFLKPLSCLQAGLLYSLIFGVLYHFPLFAYVYK----ESNQVSFIAMMVVVLFCvngTLFLALGLISAS-LMRWSAIVFS 82
Cdd:COG2194     2 FLLPRLSPLKLILLLALYFALFLNLPFWGRLLAilplDGVNLLFLLSLPLLLLA---ALNLLLSLLAWRyLFKPLLILLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739  83 WLNSVAFYFISAYKVFLNKSMMGNVLNTNTHEVLGFLSVKLFVFIVVFGVLPGYIIYKIPIK-NSSKKAP---FLAILAL 158
Cdd:COG2194    79 LISAAASYFMDFYGVVIDYGMIQNVLETDPAEASELLSPKLILWLLLLGVLPALLLWRVRIRyRPLLRELgqrLALLLLA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 159 VFIFIASALANAKNWLWFDKHAKFIGGLILPFAYSVNAFRVSALKFFAPTIKPLPLF------SPNHSNSFVVLVIGESA 232
Cdd:COG2194   159 LLVIVLLALLFYKDYASFFRNHKELRYLINPSNFIYALGKYAKARYFAAPLPLQPLGadaklaAAGAKPTLVVLVVGETA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 233 RKHNYALYGYNKPTTPRLSKRladNELTLF-NATSCATYTTASLECIL-------DSSFKNNAYENLPTYLTKAGIKVFW 304
Cdd:COG2194   239 RADNFSLNGYARDTTPELAKE---KNLVSFrDVTSCGTATAVSVPCMFsrlgradYDPQRALNQENLLDVLQRAGVKVLW 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 305 YSANDGEKNVkvTSYLKNYELIQKCSN--CEAIAPYDESLLYNLPDLLKEHSNeNVLLILHLAGSHGPNYDNKVPLNFRV 382
Cdd:COG2194   316 RDNQSGCKGV--CDRVPTIDLTADNLPplCDGGECLDEVLLDGLDEALADLAG-DKLIVLHQMGSHGPAYYKRYPPEFRK 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 383 FKPYCSSADLSSCSKESLINAYDNTIFYNDYLLDKIISMLK--KAKQPALMIYLSDHGESLGEEAFYLHGIPKSIAPKEQ 460
Cdd:COG2194   393 FTPTCDTNDLQNCSREELVNAYDNTILYTDYVLSQVIDLLKakQDRYDTAMLYVSDHGESLGENGLYLHGTPYAIAPDEQ 472

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1151294739 461 YEIPFIVYANDLFKKEHSI------IQTQTPINQNVIFHSILGVFeDFKNPsvVYRPSLDLLK 517
Cdd:COG2194   473 THVPMIMWLSDGYAQRYGIdfaclkARADKPYSHDNLFHTLLGLL-DVRTS--VYDPELDILA 532
LptA cd16017
Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine ...
 224-499 4.80e-92

Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase; Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase catalyzes the modification of the lipid A headgroups by phosphoethanolamine (PEA) or 4-amino-arabinose residues. Lipopolysaccharides, also called endotoxins, protect bacterial pathogens from antimicrobial peptides and have roles in virulence. The PEA modified lipid A increases resistance to the cationic cyclic polypeptide antibiotic, polymyxin. Lipid A PEA transferases usually consist of a transmembrane domain anchoring the enzyme to the periplasmic face of the cytoplasmic membrane.


Pssm-ID: 293741 [Multi-domain]  Cd Length: 288  Bit Score: 282.59  E-value: 4.80e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 224 VVLVIGESARKHNYALYGYNKPTTPRLSKRlaDNELTLF-NATSCATYTTASLECILdsSFKN-------NAYENLPTYL 295
Cdd:cd16017     5 VVLVIGESARRDHMSLYGYPRDTTPFLSKL--KKNLIVFdNVISCGTSTAVSLPCML--SFANrenydraYYQENLIDLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 296 TKAGIKVFWYSANDGEKNV--KVTSYLKNYELIQKCSNCEAIAPYDESLLYNLPDLLKEhSNENVLLILHLAGSHGPnYD 373
Cdd:cd16017    81 KKAGYKTYWISNQGGCGGYdtRISAIAKIETVFTNKGSCNSSNCYDEALLPLLDEALAD-SSKKKLIVLHLMGSHGP-YY 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 374 NKVPLNFRVFKPYCSSaDLSSCSKESLINAYDNTIFYNDYLLDKIISMLKKAKQPALMIYLSDHGESLGEEAFYLHGIPK 453
Cdd:cd16017   159 DRYPEEFAKFTPDCDN-ELQSCSKEELINAYDNSILYTDYVLSQIIERLKKKDKDAALIYFSDHGESLGENGLYLHGAPY 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1151294739 454 siAPKEQYEIPFIVYANDLFKKEHSIIQTQ----TPINQNVIFHSILGVF 499
Cdd:cd16017   238 --APKEQYHVPFIIWSSDSYKQRYPVERLRankdRPFSHDNLFHTLLGLL 285
PRK11598 PRK11598
putative metal dependent hydrolase; Provisional
 9-517 2.53e-80

putative metal dependent hydrolase; Provisional


Pssm-ID: 183224 [Multi-domain]  Cd Length: 545  Bit Score: 260.76  E-value: 2.53e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739   9 FLKPLSClqAGLLYSLIFGVLYHFPLFAYVYKESNQ---------VSFIAMMVVVLFCVNGTLFLALGLISasLMRWSAI 79
Cdd:PRK11598    4 LLKRPSL--NLLTFLLLAAFYITLCLNIAFYKQVLQllpldslhnVLVFASMPVVAFSVINIVFTLLSFPW--LRRPLAC 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739  80 VFSWLNSVAFYFISAYKVFLNKSMMGNVLNTNTHEVLGFLSVKLFVFIVVFGVLPGYIIYKIPIKNSSKK-----APFLA 154
Cdd:PRK11598   80 LFILVGAAAQYFMMTYGIVIDRSMIQNIFETTPAESFALMTPQMLLWLGLSGVLPALIACWIKIRPATPRwrsvlFRLAN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 155 ILALVFIFIASALANAKNWLWFDKHAKFIGGLILPFAYSVNAFRVSALKFFA--PTIK------PLPLFSPNHSNSFVVL 226
Cdd:PRK11598  160 ILVSVLLILLVAALFYKDYASLFRNNKELVKSLTPSNSIVASWSWYSHQRLAnlPLVRigedahKNPLMQNQKRKNLTIL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 227 VIGESARKHNYALYGYNKPTTPRLSKrlaDNELTLFNATSCATYTTASLECILdSSFKNNAY--------ENLPTYLTKA 298
Cdd:PRK11598  240 VVGETSRAENFSLGGYPRETNPRLAK---DNVIYFPHTTSCGTATAVSVPCMF-SNMPRKHYdeelahhqEGLLDIIQRA 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 299 GIKVFWySANDGE--------KNVKVTSYlknyELIQKCSNCEAiapYDESLLYNLPDLLKEHSNENVLlILHLAGSHGP 370
Cdd:PRK11598  316 GINVLW-NDNDGGckgacdrvPHQDVTAL----NLPGQCIDGEC---YDEVLFHGLENYINNLQGDGVI-VLHTIGSHGP 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 371 NYDNKVPLNFRVFKPYCSSADLSSCSKESLINAYDNTIFYNDYLLDKIISMLKK--AKQPALMIYLSDHGESLGEEAFYL 448
Cdd:PRK11598  387 TYYNRYPPQFRKFTPTCDTNEIQTCTQQQLVNTYDNTILYVDYIVDKAINLLKQhqDKFNTSLVYLSDHGESLGENGIYL 466

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1151294739 449 HGIPKSIAPKEQYEIPFIVYANDLFKKEHSIIQT-------QTPINQNVIFHSILGVFEdfkNPSVVYRPSLDLLK 517
Cdd:PRK11598  467 HGLPYAIAPDQQTHVPMLLWLSPDYQKRYGVDQQclqkqaqTQDYSQDNLFSTLLGLTG---VQTKEYQAADDILQ 539
Sulfatase pfam00884
Sulfatase;
224-499 7.18e-57

Sulfatase;


Pssm-ID: 459979 [Multi-domain]  Cd Length: 298  Bit Score: 191.87  E-value: 7.18e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 224 VVLVIGESARKHNYALYGYNKPTTPRLSkRLADNELTLFNATSCATYTTASLECILDSSFKNNA-------------YEN 290
Cdd:pfam00884   3 VVLVLGESLRAPDLGLYGYPRPTTPFLD-RLAEEGLLFSNFYSGGTLTAPSRFALLTGLPPHNFgsyvstpvglprtEPS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 291 LPTYLTKAGIKV--------FWYSANDGEKN--VKVTSYLKNYELIQKCSNCEAIAP----YDESLLYNLPDLLKEHSnE 356
Cdd:pfam00884  82 LPDLLKRAGYNTgaigkwhlGWYNNQSPCNLgfDKFFGRNTGSDLYADPPDVPYNCSgggvSDEALLDEALEFLDNND-K 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 357 NVLLILHLAGSHGP-NYDNKVPLNFRVFKPycssadlSSCSKESLINAYDNTIFYNDYLLDKIISMLKKAKQ--PALMIY 433
Cdd:pfam00884 161 PFFLVLHTLGSHGPpYYPDRYPEKYATFKP-------SSCSEEQLLNSYDNTLLYTDDAIGRVLDKLEENGLldNTLVVY 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1151294739 434 LSDHGESLGEEAFYLHGIPKSIAPKEQYEIPFIVYANDLFKKEHsiiQTQTPINQNVIFHSILGVF 499
Cdd:pfam00884 234 TSDHGESLGEGGGYLHGGKYDNAPEGGYRVPLLIWSPGGKAKGQ---KSEALVSHVDLFPTILDLA 296
PRK11560 PRK11560
kdo(2)-lipid A phosphoethanolamine 7''-transferase;
7-473 5.88e-44

kdo(2)-lipid A phosphoethanolamine 7''-transferase;


Pssm-ID: 183198 [Multi-domain]  Cd Length: 558  Bit Score: 163.29  E-value: 5.88e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739   7 LKFLKPLSCLQAGLLYSLIFGVLYHFPLFAYVYKESNQ----VSFIAMMVVVLFCVNGTLFLaLGLIS----------AS 72
Cdd:PRK11560    1 MRYIKSLTQQKLSFLLAVYIGLFLNIAVFYRRFDSYAQdftvWKGLSAVVELAATVLVTFFL-LRLLSlfgrrfwrvlAS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739  73 LMrwsaIVFSwlnSVAFYFISAYKVFLNKSMMGNVLNTNT---HEVLGFlsvKLFVFIVVFGVLPGYIIYKIPIKNS--- 146
Cdd:PRK11560   80 LL----VLFS---AAASYYMTFFNVVIGYGIIASVMTTDIdlsKEVVGL---HFILWLVAVSALPLILIWNNRCRYTllr 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 147 SKKAPFLAILALVFIFIASALAnaknWL---WFDKHAKF---IGGLILPFAYSVNAFR------VSALKFFAPT------ 208
Cdd:PRK11560  150 QLRTPGQRIRSLAVVVLAGLLV----WApirLLDIQQKKverATGVDLPSYGGVVANSylpsnwLSALGLYAWAqvdess 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 209 -----IKPLPLF----SPNHSNSFVVLVIGESARKHNYALYGYNKPTTPRLSKrlaDNELTLFNATSCATYTTASLECIL 279
Cdd:PRK11560  226 dnnslLNPAKKFtyqaPKGVDDTYVVFIIGETTRWDHMGILGYERNTTPKLAQ---EKNLAAFRGYSCDTATKLSLRCMF 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 280 -------DSSFKNNAYENLPTYLTKAGI---------KVFWYSandgekNVKVTSYLKNyELIQKcSNCEAIAPYDESLL 343
Cdd:PRK11560  303 vreggaeDNPQRTLKEQNVFAVLKQLGFsselfamqsEMWFYN------NTMADNYAYR-EQIGA-EPRNRGKPVDDMLL 374

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 344 YN-LPDLLKEHSNENVLLILHLAGSHGpNYDNKVPLNFRVFKPYCSSADlSSCSKESLINAYDNTIFYNDYLLDKIISML 422
Cdd:PRK11560  375 VDeMKQSLGRNPDGKHLIILHTKGSHY-NYTQRYPRSFARYQPECIGVD-SGCSKAQLINSYDNSVLYVDHFISSVIDQL 452

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1151294739 423 KKAKqpALMIYLSDHGESLGEEAfYLHGIPKSIAPKEQYEIPFIVYANDLF 473
Cdd:PRK11560  453 RDKK--AIVFYAADHGESINERE-HLHGTPREMAPPEQFRVPMMVWMSDKY 500
EptA_B_N pfam08019
Phosphoethanolamine transferase EptA/EptB; This entry represents a domain found in a group of ...
 62-199 1.66e-32

Phosphoethanolamine transferase EptA/EptB; This entry represents a domain found in a group of bacterial phosphoethanolamine transferases, including eptA from Helicobacter pylori and eptB from Escherichia coli EC:2.7.8.42. This domain is found immediately N-terminal to the sulphatase domain in many sulphatases.


Pssm-ID: 429788 [Multi-domain]  Cd Length: 151  Bit Score: 121.47  E-value: 1.66e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739  62 LFLALGLISAS-LMRWSAIVFSWLNSVAFYFISAYKVFLNKSMMGNVLNTNTHEVLGFLSVKLFVFIVVFGVLPGYIIYK 140
Cdd:pfam08019   5 LNLLLSLLSWRyLLKPLLILLLLLSAAASYFMDTYGVVIDRDMIQNVLETDVAEASDLLSPKLLLYLLLLGVLPALLLWR 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1151294739 141 IPIKNSSKKAPFLA----ILALVFIFIASALANAKNWLWFDKHAKFIGGLILPFAYSVNAFRV 199
Cdd:pfam08019  85 VRIRYRPWLRELLSrlalILVSLLVIGLVAFLFYKDYASFFRNHKELRYLINPTNYIYSTVKY 147
PRK10649 PRK10649
phosphoethanolamine transferase CptA;
225-477 5.10e-25

phosphoethanolamine transferase CptA;


Pssm-ID: 182617 [Multi-domain]  Cd Length: 577  Bit Score: 108.64  E-value: 5.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 225 VLVIGESARKHNYALYGYNKPTTPRLSK-RLADNELTLF-NATSCATYTTASLECILdsSFKNNayENLPTYLTK----- 297
Cdd:PRK10649  240 VLVIGESTQRGRMSLYGYPRETTPELDAlHKTDPGLTVFnNVVTSRPYTIEILQQAL--TFADE--KNPDLYLTQpslmn 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 298 ----AGIKVFWYS-------ANDG----EKNVKVTSYLKNyeliQKCSNCeaiAPYDESLLYNLPDLLKEhSNENVLLIL 362
Cdd:PRK10649  316 mmkqAGYKTFWITnqqtmtaRNTMltvfSRQTDKQYYMNQ----QRTQNA---REYDTNVLKPFSEVLAD-PAPKKFIIV 387

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 363 HLAGSHgPNYDNKVPLNFRVFK-------PYCSSADLSScskeslINAYDNTIFYNDYLLDKIISMLKKAKQPALMIYLS 435
Cdd:PRK10649  388 HLLGTH-IKYKYRYPENQGKFDdrtghvpPGLNADELES------YNDYDNANLYNDHVVASLIKDFKATDPNGFLVYFS 460

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1151294739 436 DHGESLgeeafYLHGIPKSIAPKE------QYEIPFIVYANDLFKKEH 477
Cdd:PRK10649  461 DHGEEV-----YDTPPHKTQGRNEdnptrhMYTIPFLLWTSEKWQAAH 503
MdoB COG1368
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ...
 24-476 3.06e-11

Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440979 [Multi-domain]  Cd Length: 576  Bit Score: 65.83  E-value: 3.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739  24 LIFGVLYHFPLFAYVYKESNQVSFIAMMVVVLFCVNGTLFLALGLISASLMRWSAIVFSWLNSVAFY----FISAYKVFL 99
Cdd:COG1368    13 LVFLLFNFDLSLGEILQAFLYGLRFILYLLLLLLLLLLLLLPLLFRRPKLRWIYLLLVLLLLLLLLVadilYYRFFGDRL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 100 NKSMMGNVlnTNTHEVLGFLS----VKLFVFIVVFGVLPGYIIY-----KIPIKNSSKKAPFLAILALVFIFIASALANA 170
Cdd:COG1368    93 NFSDLDYL--GDTGEVLGSLLssydLLLLLDLLLLLLLLLLLYRllkklRKSLPWRKRLALLLLLLALLLLGIRLGEDRP 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 171 KNWLWFDKHAKFIGGLILPFAYSV-NAFRVSALKFFAP--TIKPLPLFSPNHSNSF----------VVLVIGESARKHNY 237
Cdd:COG1368   171 LNLSDAFSRNNFVNELGLNGPYSFyDALRNNKAPATYSeeEALEIKKYLKSNRPTPnpfgpakkpnVVVILLESFSDFFI 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 238 ALYGYNKPTTPRLsKRLADNELTLFNATSCATYTTASLECILDS-----------SFKNNAYENLPTYLTKAGIKVFWYS 306
Cdd:COG1368   251 GALGNGKDVTPFL-DSLAKESLYFGNFYSQGGRTSRGEFAVLTGlpplpggspykRPGQNNFPSLPSILKKQGYETSFFH 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 307 ANDGE--------KNVKVTSYLKNYELIQKCSNceAIAPYDESLLYNLPDLLKEhSNENVLLILHLAGSHGPnYDnkVPL 378
Cdd:COG1368   330 GGDGSfwnrdsfyKNLGFDEFYDREDFDDPFDG--GWGVSDEDLFDKALEELEK-LKKPFFAFLITLSNHGP-YT--LPE 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 379 NFRVFKPYcssadlsscsKESLINAYDNTIFYNDYLLDKIISMLKKAK--QPALMIYLSDHGESLGEEAFYLHgipksia 456
Cdd:COG1368   404 EDKKIPDY----------GKTTLNNYLNAVRYADQALGEFIEKLKKSGwyDNTIFVIYGDHGPRSPGKTDYEN------- 466

                         490       500
                  ....*....|....*....|
gi 1151294739 457 PKEQYEIPFIVYANDLFKKE 476
Cdd:COG1368   467 PLERYRVPLLIYSPGLKKPK 486
LTA_synthase cd16015
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer ...
 224-476 2.78e-08

Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.


Pssm-ID: 293739 [Multi-domain]  Cd Length: 283  Bit Score: 55.00  E-value: 2.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 224 VVLVIGESARKHNYALYGYNKPTTPRLsKRLADNEL--TLFNATSCATYTTASLECIL------------DSSFKNNAYE 289
Cdd:cd16015     3 VIVILLESFSDPYIDKDVGGEDLTPNL-NKLAKEGLyfGNFYSPGFGGGTANGEFEVLtglpplplgsgsYTLYKLNPLP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 290 NLPTYLTKAGIKVFWYSANDGEkNVKVTSYLKNY---------ELIQKCSNCEAIAPYDESLLYNLPDLLKEHSNENVLL 360
Cdd:cd16015    82 SLPSILKEQGYETIFIHGGDAS-FYNRDSVYPNLgfdefydleDFPDDEKETNGWGVSDESLFDQALEELEELKKKPFFI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 361 ILHLAGSHGPNYDNKVPLNFRVFKPYcssadlsscsKESLINAYDNTIFYNDYLLDKIISMLKKAKQ--PALMIYLSDHG 438
Cdd:cd16015   161 FLVTMSNHGPYDLPEEKKDEPLKVEE----------DKTELENYLNAIHYTDKALGEFIEKLKKSGLyeNTIIVIYGDHL 230

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1151294739 439 ESLGEEAFYlhgipKSIAPKEQYEIPFIVYANDLFKKE 476
Cdd:cd16015   231 PSLGSDYDE-----TDEDPLDLYRTPLLIYSPGLKKPK 263
sulfatase_like cd16156
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the ...
 412-507 4.75e-05

uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293775 [Multi-domain]  Cd Length: 468  Bit Score: 45.84  E-value: 4.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 412 DYLLDKIISMLKKAKQPALMIYLSDHGESLGEEAFYLHGipkSIAPKEQYEIPFIVYANDlfkKEHSIIQTQTPINQNVI 491
Cdd:cd16156   251 DYEIGRVLDAADEIAEDAWVIYTSDHGDMLGAHKLWAKG---PAVYDEITNIPLIIRGKG---GEKAGTVTDTPVSHIDL 324

                          90
                  ....*....|....*.
gi 1151294739 492 FHSILGVFeDFKNPSV 507
Cdd:cd16156   325 APTILDYA-GIPQPKV 339
sulfatase_like cd16148
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
 224-468 6.81e-05

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293767 [Multi-domain]  Cd Length: 271  Bit Score: 44.85  E-value: 6.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 224 VVLVIGESARKHNYALYGYNKPTTPRLSkRLADNELTLFNATSCATYTTASLECIL----------DSSFKNNAYENLPT 293
Cdd:cd16148     3 VILIVIDSLRADHLGCYGYDRVTTPNLD-RLAAEGVVFDNHYSGSNPTLPSRFSLFtglypfyhgvWGGPLEPDDPTLAE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 294 YLTKAGIKVFWYSANDGEKNVkvTSYLKNYELIQKCSNCEAIAPY-----DESLLYNLPDLLKEH-SNENVLLILHLAGS 367
Cdd:cd16148    82 ILRKAGYYTAAVSSNPHLFGG--PGFDRGFDTFEDFRGQEGDPGEegderAERVTDRALEWLDRNaDDDPFFLFLHYFDP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151294739 368 HGPnydnkvplnFRvfkpycssadlsscskeslinaYDNTIFYNDYLLDKIISMLKK---AKQPALMIyLSDHGESLGEE 444
Cdd:cd16148   160 HEP---------YL----------------------YDAEVRYVDEQIGRLLDKLKElglLEDTLVIV-TSDHGEEFGEH 207

                         250       260
                  ....*....|....*....|....*
gi 1151294739 445 AFYL-HGipkSIAPKEQYEIPFIVY 468
Cdd:cd16148   208 GLYWgHG---SNLYDEQLHVPLIIR 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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