|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
3-320 |
0e+00 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 543.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 3 YRQIGTTDMKASCVAFGAWAIGGGPWWGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDRRDKVLIAT 82
Cdd:cd19149 1 YRKLGKSGIEASVIGLGTWAIGGGPWWGGSDDNESIRTIHAALDLGINLIDTAPAYGFGHSEEIVGKAIKGRRDKVVLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 83 KCGLWHRDARGSEWFTMGSHTIRRSLRPDTIRIEVEESLRRLGVDRIDLYQTHWQAIEpekTPIADTMACLMDLRAQGKI 162
Cdd:cd19149 81 KCGLRWDREGGSFFFVRDGVTVYKNLSPESIREEVEQSLKRLGTDYIDLYQTHWQDVE---TPIEETMEALEELKRQGKI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 163 RAIGVSNATTADMDAYRAAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKIGMDRTFGADESRNR 242
Cdd:cd19149 158 RAIGASNVSVEQIKEYVKAGQLDIIQEKYSMLDRGIEKELLPYCKKNNIAFQAYSPLEQGLLTGKITPDREFDAGDARSG 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1175985856 243 IPWFLPANRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLALDTATLARMRA 320
Cdd:cd19149 238 IPWFSPENREKVLALLEKWKPLCEKYGCTLAQLVIAWTLAQPGITSALCGARKPEQAEENAKAGDIRLSAEDIATMRS 315
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
10-319 |
3.01e-141 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 401.13 E-value: 3.01e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 10 DMKASCVAFGAWAIGGGpWWGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDRRDKVLIATKCGLWhr 89
Cdd:cd19084 1 DLKVSRIGLGTWAIGGT-WWGEVDDQESIEAIKAAIDLGINFFDTAPVYGFGHSEEILGKALKGRRDDVVIATKCGLR-- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 90 dargseWFtmGSHTIRRSLRPDTIRIEVEESLRRLGVDRIDLYQTHWqaieP-EKTPIADTMACLMDLRAQGKIRAIGVS 168
Cdd:cd19084 78 ------WD--GGKGVTKDLSPESIRKEVEQSLRRLQTDYIDLYQIHW----PdPNTPIEETAEALEKLKKEGKIRYIGVS 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 169 NATTADMDAYRAAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKIGMDRTFGADESRNRIPWFLP 248
Cdd:cd19084 146 NFSVEQLEEARKYGPIVSLQPPYSMLEREIEEELLPYCRENGIGVLPYGPLAQGLLTGKYKKEPTFPPDDRRSRFPFFRG 225
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1175985856 249 ANRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLALDTATLARMR 319
Cdd:cd19084 226 ENFEKNLEIVDKLKEIAEKYGKSLAQLAIAWTLAQPGVTSAIVGAKNPEQLEENAGALDWELTEEELKEID 296
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
1-328 |
7.61e-117 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 339.85 E-value: 7.61e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 1 MHYRQIGTTDMKASCVAFGAWAIGGgpWWGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDR-RDKVL 79
Cdd:COG0667 1 MEYRRLGRSGLKVSRLGLGTMTFGG--PWGGVDEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGEALKGRpRDDVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 80 IATKCGlwhrdargsewFTMGSHTIRRSLRPDTIRIEVEESLRRLGVDRIDLYQTHWqaIEPEkTPIADTMACLMDLRAQ 159
Cdd:COG0667 79 IATKVG-----------RRMGPGPNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHR--PDPD-TPIEETLGALDELVRE 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 160 GKIRAIGVSNATTADMDAYRAAGE----LSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKIGMDRTFG 235
Cdd:COG0667 145 GKIRYIGVSNYSAEQLRRALAIAEglppIVAVQNEYSLLDRSAEEELLPAARELGVGVLAYSPLAGGLLTGKYRRGATFP 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 236 ADeSRNRIPWFLPANRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLALDTATL 315
Cdd:COG0667 225 EG-DRAATNFVQGYLTERNLALVDALRAIAAEHGVTPAQLALAWLLAQPGVTSVIPGARSPEQLEENLAAADLELSAEDL 303
|
330
....*....|...
gi 1175985856 316 ARMRADVEALGAP 328
Cdd:COG0667 304 AALDAALAAVPAP 316
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
14-320 |
6.31e-114 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 331.86 E-value: 6.31e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 14 SCVAFGAWAIGGGPWWGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDRRDKVLIATKCGLWHrdarg 93
Cdd:cd19085 2 SRLGLGCWQFGGGYWWGDQDDEESIATIHAALDAGINFFDTAEAYGDGHSEEVLGKALKGRRDDVVIATKVSPDN----- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 94 sewftmgshtirrsLRPDTIRIEVEESLRRLGVDRIDLYQTHWQAiepEKTPIADTMACLMDLRAQGKIRAIGVSNATTA 173
Cdd:cd19085 77 --------------LTPEDVRKSCERSLKRLGTDYIDLYQIHWPS---SDVPLEETMEALEKLKEEGKIRAIGVSNFGPA 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 174 DMDAYRAAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKIGMDRTFGADESRNRIPW-FLPANRA 252
Cdd:cd19085 140 QLEEALDAGRIDSNQLPYNLLWRAIEYEILPFCREHGIGVLAYSPLAQGLLTGKFSSAEDFPPGDARTRLFRhFEPGAEE 219
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1175985856 253 RVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLALDTATLARMRA 320
Cdd:cd19085 220 ETFEALEKLKEIADELGVTMAQLALAWVLQQPGVTSVIVGARNPEQLEENAAAVDLELSPSVLERLDE 287
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-317 |
3.73e-107 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 315.00 E-value: 3.73e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 14 SCVAFGAWAIGGGPW---WGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDRRDKVLIATKCG-LWhr 89
Cdd:cd19102 2 TTIGLGTWAIGGGGWgggWGPQDDRDSIAAIRAALDLGINWIDTAAVYGLGHSEEVVGRALKGLRDRPIVATKCGlLW-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 90 DARGSewftmgshtIRRSLRPDTIRIEVEESLRRLGVDRIDLYQTHWQAiepEKTPIADTMACLMDLRAQGKIRAIGVSN 169
Cdd:cd19102 80 DEEGR---------IRRSLKPASIRAECEASLRRLGVDVIDLYQIHWPD---PDEPIEEAWGALAELKEEGKVRAIGVSN 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 170 ATTADMDAYRAAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKIGMDR--TFGADESRNRIPWFL 247
Cdd:cd19102 148 FSVDQMKRCQAIHPIASLQPPYSLLRRGIEAEILPFCAEHGIGVIVYSPMQSGLLTGKMTPERvaSLPADDWRRRSPFFQ 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 248 PANRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLALDTATLAR 317
Cdd:cd19102 228 EPNLARNLALVDALRPIAERHGRTVAQLAIAWVLRRPEVTSAIVGARRPDQIDETVGAADLRLTPEELAE 297
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
10-311 |
6.47e-100 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 296.53 E-value: 6.47e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 10 DMKASCVAFGAWAIGGGpWWGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDR--RDKVLIATKCGL- 86
Cdd:cd19148 1 DLPVSRIALGTWAIGGW-MWGGTDEKEAIETIHKALDLGINLIDTAPVYGFGLSEEIVGKALKEYgkRDRVVIATKVGLe 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 87 WHRDargsewftmgsHTIRRSLRPDTIRIEVEESLRRLGVDRIDLYQTHWqaieP-EKTPIADTMACLMDLRAQGKIRAI 165
Cdd:cd19148 80 WDEG-----------GEVVRNSSPARIRKEVEDSLRRLQTDYIDLYQVHW----PdPLVPIEETAEALKELLDEGKIRAI 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 166 GVSNATTADMDAYRAAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKIGMDRTFGADESRNRIPW 245
Cdd:cd19148 145 GVSNFSPEQMETFRKVAPLHTVQPPYNLFEREIEKDVLPYARKHNIVTLAYGALCRGLLSGKMTKDTKFEGDDLRRTDPK 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1175985856 246 FLPANRARVLAMLGGWKDLCAAH-ACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLALD 311
Cdd:cd19148 225 FQEPRFSQYLAAVEELDKLAQERyGKSVIHLAVRWLLDQPGVSIALWGARKPEQLDAVDEVFGWSLN 291
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
16-320 |
6.86e-83 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 252.62 E-value: 6.86e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 16 VAFGAWAIGGGpwWGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDR---RDKVLIATKCGlwhrdar 92
Cdd:pfam00248 1 IGLGTWQLGGG--WGPISKEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYpvkRDKVVIATKVP------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 93 gsewftMGSHTIRRSLRPDTIRIEVEESLRRLGVDRIDLYQTHWqaIEPEkTPIADTMACLMDLRAQGKIRAIGVSNATT 172
Cdd:pfam00248 72 ------DGDGPWPSGGSKENIRKSLEESLKRLGTDYIDLYYLHW--PDPD-TPIEETWDALEELKKEGKIRAIGVSNFDA 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 173 ADMDAYRAAGEL--SACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKIGMDRTFGADESRNRIPWFLPAN 250
Cdd:pfam00248 143 EQIEKALTKGKIpiVAVQVEYNLLRRRQEEELLEYCKKNGIPLIAYSPLGGGLLTGKYTRDPDKGPGERRRLLKKGTPLN 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 251 RARVLAmlggWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLALDTATLARMRA 320
Cdd:pfam00248 223 LEALEA----LEEIAKEHGVSPAQVALRWALSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDE 288
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
3-317 |
2.88e-82 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 251.37 E-value: 2.88e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 3 YRQIGTTDMKASCVAFGAwaIGGGPWWGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDRRDKVLIAT 82
Cdd:cd19076 2 TRKLGTQGLEVSALGLGC--MGMSAFYGPADEEESIATLHRALELGVTFLDTADMYGPGTNEELLGKALKDRRDEVVIAT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 83 KCGlWHRDArgsewftmGSHTIRRSLRPDTIRIEVEESLRRLGVDRIDLYQTHwqAIEPEkTPIADTMACLMDLRAQGKI 162
Cdd:cd19076 80 KFG-IVRDP--------GSGFRGVDGRPEYVRAACEASLKRLGTDVIDLYYQH--RVDPN-VPIEETVGAMAELVEEGKV 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 163 RAIGVSNATTADMDAYRAAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKIGMDRTFGADESRNR 242
Cdd:cd19076 148 RYIGLSEASADTIRRAHAVHPITAVQSEYSLWTRDIEDEVLPTCRELGIGFVAYSPLGRGFLTGAIKSPEDLPEDDFRRN 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1175985856 243 IPWFLPANRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLALDTATLAR 317
Cdd:cd19076 228 NPRFQGENFDKNLKLVEKLEAIAAEKGCTPAQLALAWVLAQGDDIVPIPGTKRIKYLEENVGALDVVLTPEELAE 302
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
14-305 |
1.32e-81 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 247.39 E-value: 1.32e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 14 SCVAFGAWAIGGgPWWGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDRRDKVLIATKCGLWHRDARG 93
Cdd:cd19086 4 SEIGFGTWGLGG-DWWGDVDDAEAIRALRAALDLGINFFDTADVYGDGHSERLLGKALKGRRDKVVIATKFGNRFDGGPE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 94 SEWFTmgshtirrslRPDTIRIEVEESLRRLGVDRIDLYQTHWQAIEPEKTPiaDTMACLMDLRAQGKIRAIGVSNATTA 173
Cdd:cd19086 83 RPQDF----------SPEYIREAVEASLKRLGTDYIDLYQLHNPPDEVLDND--ELFEALEKLKQEGKIRAYGVSVGDPE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 174 DMDAYRAAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKigmdrtfgadesrnripwflpanrar 253
Cdd:cd19086 151 EALAALRRGGIDVVQVIYNLLDQRPEEELFPLAEEHGVGVIARVPLASGLLTGK-------------------------- 204
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1175985856 254 vlamlggwkdlcaahactLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKA 305
Cdd:cd19086 205 ------------------LAQAALRFILSHPAVSTVIPGARSPEQVEENAAA 238
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
4-305 |
4.89e-80 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 245.79 E-value: 4.89e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 4 RQIGTTDMKASCVAFGAWAIGGGPWWGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDR-RDKVLIAT 82
Cdd:cd19083 2 VKLGKSDIDVNPIGLGTNAVGGHNLYPNLDEEEGKDLVREALDNGVNLLDTAFIYGLGRSEELVGEVLKEYnRNEVVIAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 83 KCGlwHRdargsewftMGSHTIRRSLRPDTIRIEVEESLRRLGVDRIDLYQTHWQaiePEKTPIADTMACLMDLRAQGKI 162
Cdd:cd19083 82 KGA--HK---------FGGDGSVLNNSPEFLRSAVEKSLKRLNTDYIDLYYIHFP---DGETPKAEAVGALQELKDEGKI 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 163 RAIGVSNATTADMDAYRAAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKIGMDRTFGADESRNR 242
Cdd:cd19083 148 RAIGVSNFSLEQLKEANKDGYVDVLQGEYNLLQREAEEDILPYCVENNISFIPYFPLASGLLAGKYTKDTKFPDNDLRND 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1175985856 243 IPWFLPANRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKA 305
Cdd:cd19083 228 KPLFKGERFSENLDKVDKLKSIADEKGVTVAHLALAWYLTRPAIDVVIPGAKRAEQVIDNLKA 290
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
1-317 |
7.47e-76 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 235.16 E-value: 7.47e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 1 MHYRQIGTTDMKASCVAFGAWAIGGgpwwgPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDRRDKVLI 80
Cdd:cd19087 1 MEYRTLGRTGLKVSRLCLGTMNFGG-----RTDEETSFAIMDRALDAGINFFDTADVYGGGRSEEIIGRWIAGRRDDIVL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 81 ATKCGlwhrdargsewFTMGSHTIRRSLRPDTIRIEVEESLRRLGVDRIDLYQTHwqAIEPeKTPIADTMACLMDLRAQG 160
Cdd:cd19087 76 ATKVF-----------GPMGDDPNDRGLSRRHIRRAVEASLRRLQTDYIDLYQMH--HFDR-DTPLEETLRALDDLVRQG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 161 KIRAIGVSN------ATTADMDAYRAAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKIGMDRTF 234
Cdd:cd19087 142 KIRYIGVSNfaawqiAKAQGIAARRGLLRFVSEQPMYNLLKRQAELEILPAARAYGLGVIPYSPLAGGLLTGKYGKGKRP 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 235 GADESRNRIPWFLPANRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLALDTAT 314
Cdd:cd19087 222 ESGRLVERARYQARYGLEEYRDIAERFEALAAEAGLTPASLALAWVLSHPAVTSPIIGPRTLEQLEDSLAALEITLTPEL 301
|
...
gi 1175985856 315 LAR 317
Cdd:cd19087 302 LAE 304
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
19-317 |
2.74e-72 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 224.42 E-value: 2.74e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 19 GAWAIGGGPWWGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDR-RDKVLIATKCGLWHrdargsewf 97
Cdd:cd19072 10 GTWGIGGGMSKDYSDDKKAIEALRYAIELGINLIDTAEMYGGGHAEELVGKAIKGFdREDLFITTKVSPDH--------- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 98 tmgshtirrsLRPDTIRIEVEESLRRLGVDRIDLYQTHWqaIEPeKTPIADTMACLMDLRAQGKIRAIGVSNATTADMDA 177
Cdd:cd19072 81 ----------LKYDDVIKAAKESLKRLGTDYIDLYLIHW--PNP-SIPIEETLRAMEELVEEGKIRYIGVSNFSLEELEE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 178 YRAA---GELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKIGmdrtfgadesrnripwflpanrarv 254
Cdd:cd19072 148 AQSYlkkGPIVANQVEYNLFDREEESGLLPYCQKNGIAIIAYSPLEKGKLSNAKG------------------------- 202
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1175985856 255 LAMLggwKDLCAAHACTLGQLVIAWTVAQPGlTIALCGARKVAQVLENAKAGGLALDTATLAR 317
Cdd:cd19072 203 SPLL---DEIAKKYGKTPAQIALNWLISKPN-VIAIPKASNIEHLEENAGALGWELSEEDLQR 261
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
1-318 |
5.95e-72 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 225.57 E-value: 5.95e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 1 MHYRQIGTTDMKASCVAFGAWAIGGGPW----WGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDRRD 76
Cdd:cd19091 1 MEYRTLGRSGLKVSELALGTMTFGGGGGffgaWGGVDQEEADRLVDIALDAGINFFDTADVYSEGESEEILGKALKGRRD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 77 KVLIATKCGLWhrdargsewftMGSHTIRRSLRPDTIRIEVEESLRRLGVDRIDLYQTH-WQAIepekTPIADTMACLMD 155
Cdd:cd19091 81 DVLIATKVRGR-----------MGEGPNDVGLSRHHIIRAVEASLKRLGTDYIDLYQLHgFDAL----TPLEETLRALDD 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 156 LRAQGKIRAIGVSN------ATTADMDAYRAAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKIG 229
Cdd:cd19091 146 LVRQGKVRYIGVSNfsawqiMKALGISERRGLARFVALQAYYSLLGRDLEHELMPLALDQGVGLLVWSPLAGGLLSGKYR 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 230 MDRTfGADESRNRIPW--FLPANRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGG 307
Cdd:cd19091 226 RGQP-APEGSRLRRTGfdFPPVDRERGYDVVDALREIAKETGATPAQVALAWLLSRPTVSSVIIGARNEEQLEDNLGAAG 304
|
330
....*....|.
gi 1175985856 308 LALDTATLARM 318
Cdd:cd19091 305 LSLTPEEIARL 315
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
14-304 |
1.28e-68 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 213.92 E-value: 1.28e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 14 SCVAFGAWAIGGgpwwgPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDR--RDKVLIATKCGlwhrda 91
Cdd:cd06660 1 SRLGLGTMTFGG-----DGDEEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKGRgnRDDVVIATKGG------ 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 92 rgsewFTMGSHTIRRSLRPDTIRIEVEESLRRLGVDRIDLYQTHWQaiePEKTPIADTMACLMDLRAQGKIRAIGVSNAT 171
Cdd:cd06660 70 -----HPPGGDPSRSRLSPEHIRRDLEESLRRLGTDYIDLYYLHRD---DPSTPVEETLEALNELVREGKIRYIGVSNWS 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 172 TADMDAYRAAG------ELSACQPRYSMLDR-AIEADVLPYCLRSNVAILAYSPLEQGlltgkigmdrtfgadesrnrip 244
Cdd:cd06660 142 AERLAEALAYAkahglpGFAAVQPQYSLLDRsPMEEELLDWAEENGLPLLAYSPLARG---------------------- 199
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 245 wflpanrarvlamlggwkdlcaahactLGQLVIAWTVAQPGLTIALCGARKVAQVLENAK 304
Cdd:cd06660 200 ---------------------------PAQLALAWLLSQPFVTVPIVGARSPEQLEENLA 232
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
10-318 |
8.76e-67 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 211.71 E-value: 8.76e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 10 DMKASCVAFGAWAI--GGGPwwgPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDRRDKVLIATKCGlW 87
Cdd:cd19078 1 GLEVSAIGLGCMGMshGYGP---PPDKEEMIELIRKAVELGITFFDTAEVYGPYTNEELVGEALKPFRDQVVIATKFG-F 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 88 HRDARGSEWFTMGShtirrslRPDTIRIEVEESLRRLGVDRIDLYQTHwqAIEPeKTPI---ADTMACLMDlraQGKIRA 164
Cdd:cd19078 77 KIDGGKPGPLGLDS-------RPEHIRKAVEGSLKRLQTDYIDLYYQH--RVDP-NVPIeevAGTMKELIK---EGKIRH 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 165 IGVSNATTADMDAYRAAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKIGMDRTFGADESRNRIP 244
Cdd:cd19078 144 WGLSEAGVETIRRAHAVCPVTAVQSEYSMMWREPEKEVLPTLEELGIGFVPFSPLGKGFLTGKIDENTKFDEGDDRASLP 223
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1175985856 245 WFLPANRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLALDTATLARM 318
Cdd:cd19078 224 RFTPEALEANQALVDLLKEFAEEKGATPAQIALAWLLAKKPWIVPIPGTTKLSRLEENIGAADIELTPEELREI 297
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
12-312 |
5.77e-64 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 204.36 E-value: 5.77e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 12 KASCVAFGAWA-IGGGpwwgpTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRD-RRDKVLIATKCglwhr 89
Cdd:cd19074 3 KVSELSLGTWLtFGGQ-----VDDEDAKACVRKAYDLGINFFDTADVYAAGQAEEVLGKALKGwPRESYVISTKV----- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 90 dargseWFTMGSHTIRRSLRPDTIRIEVEESLRRLGVDRIDLYQTHWQaiEPEkTPIADTMACLMDLRAQGKIRAIGVSN 169
Cdd:cd19074 73 ------FWPTGPGPNDRGLSRKHIFESIHASLKRLQLDYVDIYYCHRY--DPE-TPLEETVRAMDDLIRQGKILYWGTSE 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 170 ATTAD-MDAYRAAGEL-----SACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGK------IGMDRTFGAD 237
Cdd:cd19074 144 WSAEQiAEAHDLARQFglippVVEQPQYNMLWREIEEEVIPLCEKNGIGLVVWSPLAQGLLTGKyrdgipPPSRSRATDE 223
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1175985856 238 ESRNRI-PWFLPANRARVLAMlggwKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLALDT 312
Cdd:cd19074 224 DNRDKKrRLLTDENLEKVKKL----KPIADELGLTLAQLALAWCLRNPAVSSAIIGASRPEQLEENVKASGVKLSP 295
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
5-317 |
7.10e-64 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 204.37 E-value: 7.10e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 5 QIGTTDMKASCVAFGAWAIGggpWWgpTDDAESIRAIHAAIDAGINLIDTAPMY-------EYGKSEELVGRAIRDR--R 75
Cdd:cd19081 1 PLGRTGLSVSPLCLGTMVFG---WT--ADEETSFALLDAFVDAGGNFIDTADVYsawvpgnAGGESETIIGRWLKSRgkR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 76 DKVLIATKCGLWHRDARgsewftmgshtirRSLRPDTIRIEVEESLRRLGVDRIDLYQTHWqaiEPEKTPIADTMACLMD 155
Cdd:cd19081 76 DRVVIATKVGFPMGPNG-------------PGLSRKHIRRAVEASLRRLQTDYIDLYQAHW---DDPATPLEETLGALND 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 156 LRAQGKIRAIGVSNATtadmdAYRAAGELSAC-----------QPRYSMLDRA-IEADVLPYCLRSNVAILAYSPLEQGL 223
Cdd:cd19081 140 LIRQGKVRYIGASNYS-----AWRLQEALELSrqhglpryvslQPEYNLVDREsFEGELLPLCREEGIGVIPYSPLAGGF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 224 LTGKigMDRTFGADESRNRIPWFLPANRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENA 303
Cdd:cd19081 215 LTGK--YRSEADLPGSTRRGEAAKRYLNERGLRILDALDEVAAEHGATPAQVALAWLLARPGVTAPIAGARTVEQLEDLL 292
|
330
....*....|....
gi 1175985856 304 KAGGLALDTATLAR 317
Cdd:cd19081 293 AAAGLRLTDEEVAR 306
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
22-317 |
9.54e-64 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 202.86 E-value: 9.54e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWW---GPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDRRDKVLIATKCGLWHRDARGsewft 98
Cdd:cd19138 13 ALGQGTWYmgeDPAKRAQEIEALRAGIDLGMTLIDTAEMYGDGGSEELVGEAIRGRRDKVFLVSKVLPSNASRQG----- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 99 mgshtIRRSLrpdtirievEESLRRLGVDRIDLYQTHWqaiePEKTPIADTMACLMDLRAQGKIRAIGVSNATTADM-DA 177
Cdd:cd19138 88 -----TVRAC---------ERSLRRLGTDYLDLYLLHW----RGGVPLAETVAAMEELKKEGKIRAWGVSNFDTDDMeEL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 178 YRAAG--ELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGlltgkigmdrtfgadesrNRIPWFLPANRArvl 255
Cdd:cd19138 150 WAVPGggNCAANQVLYNLGSRGIEYDLLPWCREHGVPVMAYSPLAQG------------------GLLRRGLLENPT--- 208
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1175985856 256 amlggWKDLCAAHACTLGQLVIAWTVAQPGlTIALCGARKVAQVLENAKAGGLALDTATLAR 317
Cdd:cd19138 209 -----LKEIAARHGATPAQVALAWVLRDGN-VIAIPKSGSPEHARENAAAADLELTEEDLAE 264
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
12-311 |
5.30e-63 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 201.69 E-value: 5.30e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 12 KASCVAFGAWAIGGGPWWG--PTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDR--RDKVLIATK-CGL 86
Cdd:cd19093 1 EVSPLGLGTWQWGDRLWWGygEYGDEDLQAAFDAALEAGVNLFDTAEVYGTGRSERLLGRFLKELgdRDEVVIATKfAPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 87 WHRdargsewftmgshtirrsLRPDTIRIEVEESLRRLGVDRIDLYQTHWQAIEPEKTP-IADTMAclmDLRAQGKIRAI 165
Cdd:cd19093 81 PWR------------------LTRRSVVKALKASLERLGLDSIDLYQLHWPGPWYSQIEaLMDGLA---DAVEEGLVRAV 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 166 GVSNATTADM----DAYRAAG-ELSACQPRYSMLDRAIEAD-VLPYCLRSNVAILAYSPLEQGLLTGKigmdrtFGADE- 238
Cdd:cd19093 140 GVSNYSADQLrrahKALKERGvPLASNQVEYSLLYRDPEQNgLLPACDELGITLIAYSPLAQGLLTGK------YSPENp 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1175985856 239 -SRNRIPWFLPANRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPglTIALCGARKVAQVLENAKAGGLALD 311
Cdd:cd19093 214 pPGGRRRLFGRKNLEKVQPLLDALEEIAEKYGKTPAQVALNWLIAKG--VVPIPGAKNAEQAEENAGALGWRLS 285
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
3-318 |
9.69e-63 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 201.66 E-value: 9.69e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 3 YRQIGTTDMKASCVAFGAWAIGGGPWWGPT-DDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRD--RRDKVL 79
Cdd:cd19079 2 YVRLGNSGLKVSRLCLGCMSFGDPKWRPWVlDEEESRPIIKRALDLGINFFDTANVYSGGASEEILGRALKEfaPRDEVV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 80 IATKCGlwhrdargsewFTMGSHTIRRSLRPDTIRIEVEESLRRLGVDRIDLYQTHWqaIEPEkTPIADTMACLMDLRAQ 159
Cdd:cd19079 82 IATKVY-----------FPMGDGPNGRGLSRKHIMAEVDASLKRLGTDYIDLYQIHR--WDYE-TPIEETLEALHDVVKS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 160 GKIRAIGVSNattadMDAYR-----AAGELS------ACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKI 228
Cdd:cd19079 148 GKVRYIGASS-----MYAWQfakalHLAEKNgwtkfvSMQNHYNLLYREEEREMIPLCEEEGIGVIPWSPLARGRLARPW 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 229 GMDRTfgADESRNRIP----WFLPANRARVLAMLggwKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAK 304
Cdd:cd19079 223 GDTTE--RRRSTTDTAklkyDYFTEADKEIVDRV---EEVAKERGVSMAQVALAWLLSKPGVTAPIVGATKLEHLEDAVA 297
|
330
....*....|....
gi 1175985856 305 AGGLALDTATLARM 318
Cdd:cd19079 298 ALDIKLSEEEIKYL 311
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
1-316 |
3.19e-57 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 186.99 E-value: 3.19e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 1 MHYRQIGTTDMKASCVAFGAWAIGGgpWWGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRD-RRDKVL 79
Cdd:cd19163 1 MKYRKLGKTGLKVSKLGFGASPLGG--VFGPVDEEEAIRTVHEALDSGINYIDTAPWYGQGRSETVLGKALKGiPRDSYY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 80 IATKCGlwhR-DARGSEWFTMGSHTIRRSlrpdtirieVEESLRRLGVDRIDLYQTHwqaiEPEKTP-----IADTMACL 153
Cdd:cd19163 79 LATKVG---RyGLDPDKMFDFSAERITKS---------VEESLKRLGLDYIDIIQVH----DIEFAPsldqiLNETLPAL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 154 MDLRAQGKIRAIGVsnaTTADMDAYRAAGELSACQ-------PRYSMLDRAIEaDVLPYCLRSNVAILAYSPLEQGLLTg 226
Cdd:cd19163 143 QKLKEEGKVRFIGI---TGYPLDVLKEVLERSPVKidtvlsyCHYTLNDTSLL-ELLPFFKEKGVGVINASPLSMGLLT- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 227 kigmdrtfgadesrNRIP--WFlPAN---RARVLAMLggwkDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLE 301
Cdd:cd19163 218 --------------ERGPpdWH-PASpeiKEACAKAA----AYCKSRGVDISKLALQFALSNPDIATTLVGTASPENLRK 278
|
330
....*....|....*
gi 1175985856 302 NAKAGGLALDTATLA 316
Cdd:cd19163 279 NLEAAEEPLDAHLLA 293
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
16-311 |
5.40e-57 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 185.11 E-value: 5.40e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 16 VAFGAWAI-GGGPWWGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDRRDKVLIATKCGL-------W 87
Cdd:cd19088 4 LGYGAMRLtGPGIWGPPADREEAIAVLRRALELGVNFIDTADSYGPDVNERLIAEALHPYPDDVVIATKGGLvrtgpgwW 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 88 HRDArgsewftmgshtirrslRPDTIRIEVEESLRRLGVDRIDLYQTHWqaIEPeKTPIADTMACLMDLRAQGKIRAIGV 167
Cdd:cd19088 84 GPDG-----------------SPEYLRQAVEASLRRLGLDRIDLYQLHR--IDP-KVPFEEQLGALAELQDEGLIRHIGL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 168 SNATTADMDAYRAAGELSACQPRYSMLDRAiEADVLPYCLRSNVAILAYSPLEQGLLTGKigmdrtfgadesrnripwfl 247
Cdd:cd19088 144 SNVTVAQIEEARAIVRIVSVQNRYNLANRD-DEGVLDYCEAAGIAFIPWFPLGGGDLAQP-------------------- 202
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1175985856 248 panrarvlamLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLALD 311
Cdd:cd19088 203 ----------GGLLAEVAARLGATPAQVALAWLLARSPVMLPIPGTSSVEHLEENLAAAGLRLS 256
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
4-317 |
4.39e-54 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 179.34 E-value: 4.39e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 4 RQIGTTDMKASCVAFGAWAIGGGPWWGpTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDRRDKVLIATK 83
Cdd:cd19080 1 RLLGRSGLRVSPLALGTMTFGTEWGWG-ADREEARAMFDAYVEAGGNFIDTANNYTNGTSERLLGEFIAGNRDRIVLATK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 84 cglwhrdargsewFTMGSHTI--------RRSLrpdtiRIEVEESLRRLGVDRIDLYQTH-WQAIepekTPIADTMACLM 154
Cdd:cd19080 80 -------------YTMNRRPGdpnaggnhRKNL-----RRSVEASLRRLQTDYIDLLYVHaWDFT----TPVEEVMRALD 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 155 DLRAQGKIRAIGVSN-----ATTADMDA-YRAAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKI 228
Cdd:cd19080 138 DLVRAGKVLYVGISDtpawvVARANTLAeLRGWSPFVALQIEYSLLERTPERELLPMARALGLGVTPWSPLGGGLLTGKY 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 229 GMDRTfGADESRNRIPWFLPANRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGL 308
Cdd:cd19080 218 QRGEE-GRAGEAKGVTVGFGKLTERNWAIVDVVAAVAEELGRSAAQVALAWVRQKPGVVIPIIGARTLEQLKDNLGALDL 296
|
....*....
gi 1175985856 309 ALDTATLAR 317
Cdd:cd19080 297 TLSPEQLAR 305
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
16-305 |
5.99e-54 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 177.75 E-value: 5.99e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 16 VAFGAWAIGGGpwWGPTDDAESIRAIHAAIDAGINLIDTAPMyeYGKSEELVGRAIRD-RRDKVLIATKCGlWHRDARGs 94
Cdd:cd19090 3 LGLGTAGLGGV--FGGVDDDEAVATIRAALDLGINYIDTAPA--YGDSEERLGLALAElPREPLVLSTKVG-RLPEDTA- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 95 ewftmgshtiRRSlrPDTIRIEVEESLRRLGVDRIDLYQTHwqaiEPEKTPIADTMA------CLMDLRAQGKIRAIGVS 168
Cdd:cd19090 77 ----------DYS--ADRVRRSVEESLERLGRDRIDLLMIH----DPERVPWVDILApggaleALLELKEEGLIKHIGLG 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 169 NATTADMDAYRAAGE----LSACqpRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKigmdrtfGADESRNRIP 244
Cdd:cd19090 141 GGPPDLLRRAIETGDfdvvLTAN--RYTLLDQSAADELLPAAARHGVGVINASPLGMGLLAGR-------PPERVRYTYR 211
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1175985856 245 WFLPANRARVLAMlggwKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKA 305
Cdd:cd19090 212 WLSPELLDRAKRL----YELCDEHGVPLPALALRFLLRDPRISTVLVGASSPEELEQNVAA 268
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
35-325 |
1.06e-53 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 178.91 E-value: 1.06e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 35 AESIRAIHAAIDAGINLIDTAPMY-------EYGKSEELVGRAIRDR--RDKVLIATK-CGlwhrdaRGSEWFTMGSHTI 104
Cdd:cd19094 18 AEAHEQLDYAFDEGVNFIDTAEMYpvppspeTQGRTEEIIGSWLKKKgnRDKVVLATKvAG------PGEGITWPRGGGT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 105 RrsLRPDTIRIEVEESLRRLGVDRIDLYQTHW---------------QAIEPEKTPIADTMACLMDLRAQGKIRAIGVSN 169
Cdd:cd19094 92 R--LDRENIREAVEGSLKRLGTDYIDLYQLHWpdrytplfgggyytePSEEEDSVSFEEQLEALGELVKAGKIRHIGLSN 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 170 ATT-ADMDAYRAAGELSA-----CQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKIgMDRTFGADESR-NR 242
Cdd:cd19094 170 ETPwGVMKFLELAEQLGLprivsIQNPYSLLNRNFEEGLAEACHRENVGLLAYSPLAGGVLTGKY-LDGAARPEGGRlNL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 243 IPWFLPA-NRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLALDTATLarmrAD 321
Cdd:cd19094 249 FPGYMARyRSPQALEAVAEYVKLARKHGLSPAQLALAWVRSRPFVTSTIIGATTLEQLKENIDAFDVPLSDELL----AE 324
|
....
gi 1175985856 322 VEAL 325
Cdd:cd19094 325 IDAV 328
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
4-324 |
3.11e-51 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 172.24 E-value: 3.11e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 4 RQIGTTDMKASCVAFGAWAIGGGpWWGPTDDAESIRAIHAAIDAGINLIDTAPMYeyGKSEELVGRAIRD---RRDKVLI 80
Cdd:cd19144 4 RTLGRNGPSVPALGFGAMGLSAF-YGPPKPDEERFAVLDAAFELGCTFWDTADIY--GDSEELIGRWFKQnpgKREKIFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 81 ATKCGLwHRDARGSEWFTMGShtirrslrPDTIRIEVEESLRRLGVDRIDLYQTHwqAIEPeKTPIADTMACLMDLRAQG 160
Cdd:cd19144 81 ATKFGI-EKNVETGEYSVDGS--------PEYVKKACETSLKRLGVDYIDLYYQH--RVDG-KTPIEKTVAAMAELVQEG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 161 KIRAIGVSNATTADMDAYRAAGELSACQPRYSMLDRAIE---ADVLPYCLRSNVAILAYSPLEQGLLTGKIGMDRTFGAD 237
Cdd:cd19144 149 KIKHIGLSECSAETLRRAHAVHPIAAVQIEYSPFSLDIErpeIGVLDTCRELGVAIVAYSPLGRGFLTGAIRSPDDFEEG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 238 ESRNRIPWFLPANRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLALDTATLAR 317
Cdd:cd19144 229 DFRRMAPRFQAENFPKNLELVDKIKAIAKKKNVTAGQLTLAWLLAQGDDIIPIPGTTKLKRLEENLGALKVKLTEEEEKE 308
|
....*..
gi 1175985856 318 MRADVEA 324
Cdd:cd19144 309 IREIAEE 315
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
14-305 |
1.23e-50 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 168.57 E-value: 1.23e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 14 SCVAFGAWAIGGGpwWGPTDDAESIRAIHAAIDAGINLIDTAPMyeYGKSEELVGRAIRD-RRDKVLIATKCGLWHRDAR 92
Cdd:cd19095 1 SVLGLGTSGIGRV--WGVPSEAEAARLLNTALDLGINLIDTAPA--YGRSEERLGRALAGlRRDDLFIATKVGTHGEGGR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 93 GSEWFTmgshtirrslrPDTIRIEVEESLRRLGVDRIDLYQTHWQAIEPEKtpiADTMACLMDLRAQGKIRAIGVSNaTT 172
Cdd:cd19095 77 DRKDFS-----------PAAIRASIERSLRRLGTDYIDLLQLHGPSDDELT---GEVLETLEDLKAAGKVRYIGVSG-DG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 173 ADMDAYRAAGELSACQPRYSMLDRAiEADVLPYCLRSNVAILAYSPLEQGLLTGKIgmdRTFGADESRNRIPWFLPAnra 252
Cdd:cd19095 142 EELEAAIASGVFDVVQLPYNVLDRE-EEELLPLAAEAGLGVIVNRPLANGRLRRRV---RRRPLYADYARRPEFAAE--- 214
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1175985856 253 rvlamLGGWkdlcaahacTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKA 305
Cdd:cd19095 215 -----IGGA---------TWAQAALRFVLSHPGVSSAIVGTTNPEHLEENLAA 253
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
22-320 |
4.43e-49 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 164.84 E-value: 4.43e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWwgPTDDAESIRAIHAAIDAGINLIDTAPMYEygkSEELVGRAIRD---RRDKVLIATKcgLWHRDARgsewft 98
Cdd:COG0656 7 ALGLGTW--QLPGEEAAAAVRTALEAGYRHIDTAAMYG---NEEGVGEAIAAsgvPREELFVTTK--VWNDNHG------ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 99 mgshtirrslrPDTIRIEVEESLRRLGVDRIDLYQTHWqaiePEKTPIADTMACLMDLRAQGKIRAIGVSNATTADMD-A 177
Cdd:COG0656 74 -----------YDDTLAAFEESLERLGLDYLDLYLIHW----PGPGPYVETWRALEELYEEGLIRAIGVSNFDPEHLEeL 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 178 YRAAGELSAC-QPRYSMLDRaiEADVLPYCLRSNVAILAYSPLEQGlltgkigmdRTFGADesrnripwflpanrarVLA 256
Cdd:COG0656 139 LAETGVKPAVnQVELHPYLQ--QRELLAFCREHGIVVEAYSPLGRG---------KLLDDP----------------VLA 191
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1175985856 257 MLGgwkdlcAAHACTLGQLVIAWTVAQpGlTIALCGARKVAQVLENAKAGGLALDTATLARMRA 320
Cdd:COG0656 192 EIA------EKHGKTPAQVVLRWHLQR-G-VVVIPKSVTPERIRENLDAFDFELSDEDMAAIDA 247
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
28-319 |
5.11e-47 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 160.87 E-value: 5.11e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 28 WWG-PTDDAESIRAIHAAIDAGINLIDTAPMY---EYGKSEELVGRAIR---DRRDKVLIATKCGlwhrdargsewftMG 100
Cdd:cd19077 17 WRPnPTPDEEAFETMKAALDAGSNLWNGGEFYgppDPHANLKLLARFFRkypEYADKVVLSVKGG-------------LD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 101 SHTIRRSLRPDTIRIEVEESLRRLG-VDRIDLYQThwqAIEPEKTPIADTMACLMDLRAQGKIRAIGVSNATTADMDAYR 179
Cdd:cd19077 84 PDTLRPDGSPEAVRKSIENILRALGgTKKIDIFEP---ARVDPNVPIEETIKALKELVKEGKIRGIGLSEVSAETIRRAH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 180 AAGELSACQPRYSMLDRAIE-ADVLPYCLRSNVAILAYSPLEQGLLTGKIGMDRTFGADESRNRIPWFLPANRARVLAML 258
Cdd:cd19077 161 AVHPIAAVEVEYSLFSREIEeNGVLETCAELGIPIIAYSPLGRGLLTGRIKSLADIPEGDFRRHLDRFNGENFEKNLKLV 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1175985856 259 GGWKDLCAAHACTLGQLVIAWTVAQPGLTI-ALCGARKVAQVLENAKAGGLALDTATLARMR 319
Cdd:cd19077 241 DALQELAEKKGCTPAQLALAWILAQSGPKIiPIPGSTTLERVEENLKAANVELTDEELKEIN 302
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
4-310 |
8.03e-46 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 157.59 E-value: 8.03e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 4 RQIGTTDMKASCVAFGAWAIGGgpWWG-PTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRD-RRDKVLIA 81
Cdd:cd19145 3 VKLGSQGLEVSAQGLGCMGLSG--DYGaPKPEEEGIALIHHAFNSGVTFLDTSDIYGPNTNEVLLGKALKDgPREKVQLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 82 TKCGLWHRDARGSEwftmgshtIRRSlrPDTIRIEVEESLRRLGVDRIDLYQTHwqAIEpEKTPIADTMACLMDLRAQGK 161
Cdd:cd19145 81 TKFGIHEIGGSGVE--------VRGD--PAYVRAACEASLKRLDVDYIDLYYQH--RID-TTVPIEITMGELKKLVEEGK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 162 IRAIGVSNATTADMDAYRAAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKIGMDRTFGADESRN 241
Cdd:cd19145 148 IKYIGLSEASADTIRRAHAVHPITAVQLEWSLWTRDIEEEIIPTCRELGIGIVPYSPLGRGFFAGKAKLEELLENSDVRK 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1175985856 242 RIPWFLPANRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLAL 310
Cdd:cd19145 228 SHPRFQGENLEKNKVLYERVEALAKKKGCTPAQLALAWVLHQGEDVVPIPGTTKIKNLNQNIGALSVKL 296
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
3-232 |
2.56e-45 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 154.18 E-value: 2.56e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 3 YRQIGTTDMKASCVAFGAWAIGGGPwwgptdDAESIRAIHAAIDAGINLIDTAPmyEYGKSEELVGRAIRDRRDKVLIAT 82
Cdd:cd19100 1 YRRLGRTGLKVSRLGFGGGPLGRLS------QEEAAAIIRRALDLGINYFDTAP--SYGDSEEKIGKALKGRRDKVFLAT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 83 KcgLWHRDArgsewftmgshtirrslrpDTIRIEVEESLRRLGVDRIDLYQTHwqAIEPEKTPIADT-----MACLMDLR 157
Cdd:cd19100 73 K--TGARDY-------------------EGAKRDLERSLKRLGTDYIDLYQLH--AVDTEEDLDQVFgpggaLEALLEAK 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 158 AQGKIRAIGVSNATTadmDAYRAA---GELSACQPRYSMLDRAI---EADVLPYCLRSNVAILAYSPLEQGLLTGKIGMD 231
Cdd:cd19100 130 EEGKIRFIGISGHSP---EVLLRAletGEFDVVLFPINPAGDHIdsfREELLPLAREKGVGVIAMKVLAGGRLLSGDPLD 206
|
.
gi 1175985856 232 R 232
Cdd:cd19100 207 P 207
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
32-305 |
7.74e-45 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 154.80 E-value: 7.74e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 32 TDDAESIRAIHAAIDAGINLIDTAPMYEY-------GKSEELVGRAIRDR--RDKVLIATKCGLWHRDARGSEwftmgsh 102
Cdd:cd19752 14 TDEETSFAILDRYVAAGGNFLDTANNYAFwteggvgGESERLIGRWLKDRgnRDDVVIATKVGAGPRDPDGGP------- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 103 TIRRSLRPDTIRIEVEESLRRLGVDRIDLYQTHwqaIEPEKTPIADTMACLMDLRAQGKIRAIGVSNATT---ADMDAY- 178
Cdd:cd19752 87 ESPEGLSAETIEQEIDKSLRRLGTDYIDLYYAH---VDDRDTPLEETLEAFNELVKAGKVRAIGASNFAAwrlERARQIa 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 179 RAAG--ELSACQPRYSML----------DRAIEADVLPYC-LRSNVAILAYSPLEQGLLTgkigmdrtfgADESRNRIPW 245
Cdd:cd19752 164 RQQGwaEFSAIQQRHSYLrprpgadfgvQRIVTDELLDYAsSRPDLTLLAYSPLLSGAYT----------RPDRPLPEQY 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 246 FLPANRARvLAMLggwKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKA 305
Cdd:cd19752 234 DGPDSDAR-LAVL---EEVAGELGATPNQVVLAWLLHRTPAIIPLLGASTVEQLEENLAA 289
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
1-305 |
1.14e-44 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 153.12 E-value: 1.14e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 1 MHYRQIGTTDMKASCVAFGawaigGGPWwgptdDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRD-RRDKVL 79
Cdd:cd19105 1 MPYRTLGKTGLKVSRLGFG-----GGGL-----PRESPELLRRALDLGINYFDTAEGYGNGNSEEIIGEALKGlRRDKVF 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 80 IATKCGLWhrdargsewftmgshtiRRSLRPDTIRIEVEESLRRLGVDRIDLYQTHwqAIEPEKTPIAD--TMACLMDLR 157
Cdd:cd19105 71 LATKASPR-----------------LDKKDKAELLKSVEESLKRLQTDYIDIYQLH--GVDTPEERLLNeeLLEALEKLK 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 158 AQGKIRAIGVS-NATTADMdAYRAA--GELSACQPRYSMLDRAIEAD-VLPYCLRSNVAIlayspleqglltgkIGMdRT 233
Cdd:cd19105 132 KEGKVRFIGFStHDNMAEV-LQAAIesGWFDVIMVAYNFLNQPAELEeALAAAAEKGIGV--------------VAM-KT 195
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1175985856 234 FGadeSRNRIPWFLPANRArvlamlGGWkdlcaahacTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKA 305
Cdd:cd19105 196 LA---GGYLQPALLSVLKA------KGF---------SLPQAALKWVLSNPRVDTVVPGMRNFAELEENLAA 249
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
3-305 |
3.21e-43 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 150.87 E-value: 3.21e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 3 YRQIGTTDMKASCVAFGAWAIGGGpwwgpTDDAESIRAI-HAAIDAGINLIDTAPMY--EYGKSEELVGRAIRD----RR 75
Cdd:cd19089 1 YRRCGRSGLHLPAISLGLWHNFGD-----YTSPEEARELlRTAFDLGITHFDLANNYgpPPGSAEENFGRILKRdlrpYR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 76 DKVLIATKCGlwhrdargsewFTM-----GSHTIRRSLRPdtiriEVEESLRRLGVDRIDLYQTHwqAIEPEkTPIADTM 150
Cdd:cd19089 76 DELVISTKAG-----------YGMwpgpyGDGGSRKYLLA-----SLDQSLKRMGLDYVDIFYHH--RYDPD-TPLEETM 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 151 ACLMDLRAQGKIRAIGVSNATTADmdAYRAAGELS-------ACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGL 223
Cdd:cd19089 137 TALADAVRSGKALYVGISNYPGAK--ARRAIALLRelgvpliIHQPRYSLLDRWAEDGLLEVLEEAGIGFIAFSPLAQGL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 224 LTGKigmdRTFG--ADESRNRIPWFL--PANRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQV 299
Cdd:cd19089 215 LTDK----YLNGipPDSRRAAESKFLteEALTPEKLEQLRKLNKIAAKRGQSLAQLALSWVLRDPRVTSVLIGASSPSQL 290
|
....*.
gi 1175985856 300 LENAKA 305
Cdd:cd19089 291 EDNVAA 296
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
12-315 |
7.48e-43 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 148.49 E-value: 7.48e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 12 KASCVAFGAWAIGGGPWWGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRD-RRDKVLIATKcgLWHRD 90
Cdd:cd19137 3 KIPALGLGTWGIGGFLTPDYSRDEEMVELLKTAIELGYTHIDTAEMYGGGHTEELVGKAIKDfPREDLFIVTK--VWPTN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 91 argsewftmgshtirrsLRPDTIRIEVEESLRRLGVDRIDLYQTHWqaiePEKT-PIADTMACLMDLRAQGKIRAIGVSN 169
Cdd:cd19137 81 -----------------LRYDDLLRSLQNSLRRLDTDYIDLYLIHW----PNPNiPLEETLSAMAEGVRQGLIRYIGVSN 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 170 attADMDAYRAAGELSAC-----QPRYSMLDRAIEAD-VLPYCLRSNVAILAYSPLEQGLltgkigmdrtfgadesrnri 243
Cdd:cd19137 140 ---FNRRLLEEAISKSQTpivcnQVKYNLEDRDPERDgLLEYCQKNGITVVAYSPLRRGL-------------------- 196
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1175985856 244 pwfLPANRArvlamlggWKDLCAAHACTLGQLVIAWTVAQPGLtIALCGARKVAQVLENAKAGGLALDTATL 315
Cdd:cd19137 197 ---EKTNRT--------LEEIAKNYGKTIAQIALAWLIQKPNV-VAIPKAGRVEHLKENLKATEIKLSEEEM 256
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
8-311 |
9.88e-43 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 149.24 E-value: 9.88e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 8 TTDMKASCVAFGAWAIGGgpWWGPTDDAEsiRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIR---DRRDKVLIATKC 84
Cdd:cd19092 1 PEGLEVSRLVLGCMRLAD--WGESAEELL--SLIEAALELGITTFDHADIYGGGKCEELFGEALAlnpGLREKIEIQTKC 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 85 GLwhrdargSEWFTMGSHTIRR-SLRPDTIRIEVEESLRRLGVDRIDLYQTHWQA--IEPEKTpiADTMAclmDLRAQGK 161
Cdd:cd19092 77 GI-------RLGDDPRPGRIKHyDTSKEHILASVEGSLKRLGTDYLDLLLLHRPDplMDPEEV--AEAFD---ELVKSGK 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 162 IRAIGVSNATTADMDAYRAA--GELSACQPRYSMLDR-AIEADVLPYCLRSNVAILAYSPLEQGlltgkigmdRTFGADE 238
Cdd:cd19092 145 VRYFGVSNFTPSQIELLQSYldQPLVTNQIELSLLHTeAIDDGTLDYCQLLDITPMAWSPLGGG---------RLFGGFD 215
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1175985856 239 SRNRipwflpanraRVLAMLggwKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLALD 311
Cdd:cd19092 216 ERFQ----------RLRAAL---EELAEEYGVTIEAIALAWLLRHPARIQPILGTTNPERIRSAVKALDIELT 275
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
3-320 |
3.89e-42 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 148.57 E-value: 3.89e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 3 YRQIGTTDMKASCVAFGAWAIGGgpWWGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDRRDKVLIAT 82
Cdd:cd19104 2 YRRFGRTGLKVSELTFGGGGIGG--LMGRTTREEQIAAVRRALDLGINFFDTAPSYGDGKSEENLGRALKGLPAGPYITT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 83 KCGLwhRDARGSEwftMGSHtIRRSlrpdtirieVEESLRRLGVDRIDLYQTHWQAIEPE---------------KTPIA 147
Cdd:cd19104 80 KVRL--DPDDLGD---IGGQ-IERS---------VEKSLKRLKRDSVDLLQLHNRIGDERdkpvggtlsttdvlgLGGVA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 148 DTMAclmDLRAQGKIRAIGVSNattadMDAYRAAGEL------------------SACQPRYSMLDRAIEADVLPYCLRS 209
Cdd:cd19104 145 DAFE---RLRSEGKIRFIGITG-----LGNPPAIRELldsgkfdavqvyynllnpSAAEARPRGWSAQDYGGIIDAAAEH 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 210 NVAILAYSPLEQGLLTGKIgmdRTFGADESRNRIPWFLPANRARVLamlggwKDLCAAHACTLGQLVIAWTVAQPGLTIA 289
Cdd:cd19104 217 GVGVMGIRVLAAGALTTSL---DRGREAPPTSDSDVAIDFRRAAAF------RALAREWGETLAQLAHRFALSNPGVSTV 287
|
330 340 350
....*....|....*....|....*....|..
gi 1175985856 290 LCGARKVAQVLENAKAGGLA-LDTATLARMRA 320
Cdd:cd19104 288 LVGVKNREELEEAVAAEAAGpLPAENLARLEA 319
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
1-327 |
1.86e-41 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 147.66 E-value: 1.86e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 1 MHYRQIGTTDMKASCVAFGAWAIgggpwwgPTDDAESIRA-IHAAIDAGINLIDTAPMYeyGKSEELVGRAIRDRRDKVL 79
Cdd:COG1453 1 MQYRRLGKTGLEVSVLGFGGMRL-------PRKDEEEAEAlIRRAIDNGINYIDTARGY--GDSEEFLGKALKGPRDKVI 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 80 IATKCGLWHRDargsewftmgshtirrslrPDTIRIEVEESLRRLGVDRIDLYQTH----WQAIEpekTPIADT--MACL 153
Cdd:COG1453 72 LATKLPPWVRD-------------------PEDMRKDLEESLKRLQTDYIDLYLIHglntEEDLE---KVLKPGgaLEAL 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 154 MDLRAQGKIRAIGVSN-ATTADMDAYRAAGELSACQPRYSMLDR--AIEADVLPYCLRSNVAILAYSPLEQGLLTgkigm 230
Cdd:COG1453 130 EKAKAEGKIRHIGFSThGSLEVIKEAIDTGDFDFVQLQYNYLDQdnQAGEEALEAAAEKGIGVIIMKPLKGGRLA----- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 231 dRTFGADESRNRIPWFlPAnrarvlamlggwkdlcaahactlgQLVIAWTVAQPGLTIALCGARKVAQVLENAKAG--GL 308
Cdd:COG1453 205 -NPPEKLVELLCPPLS-PA------------------------EWALRFLLSHPEVTTVLSGMSTPEQLDENLKTAdnLE 258
|
330
....*....|....*....
gi 1175985856 309 ALDTATLARMRADVEALGA 327
Cdd:COG1453 259 PLTEEELAILERLAEELGE 277
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
33-306 |
3.49e-41 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 145.00 E-value: 3.49e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 33 DDAESIRAIHAAIDAGINLIDTAPMY----EYGKSEELVGRAIRDR--RDKVLIATKCGlwHRDargsewftMGSHTIRR 106
Cdd:cd19082 15 DEEEAFALLDAFVELGGNFIDTARVYgdwvERGASERVIGEWLKSRgnRDKVVIATKGG--HPD--------LEDMSRSR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 107 sLRPDTIRIEVEESLRRLGVDRIDLYQTHwqaIEPEKTPIADTMACLMDLRAQGKIRAIGVSNATTADMDA---YRAAG- 182
Cdd:cd19082 85 -LSPEDIRADLEESLERLGTDYIDLYFLH---RDDPSVPVGEIVDTLNELVRAGKIRAFGASNWSTERIAEanaYAKAHg 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 183 --ELSACQPRYSMLDR-----------AIEADVLPYCLRSNVAILAYSPLEQGLLTGKIGMDRTFGADESRnriPWFLPA 249
Cdd:cd19082 161 lpGFAASSPQWSLARPneppwpgptlvAMDEEMRAWHEENQLPVFAYSSQARGFFSKRAAGGAEDDSELRR---VYYSEE 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1175985856 250 NRARVLAMlggwKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAG 306
Cdd:cd19082 238 NFERLERA----KELAEEKGVSPTQIALAYVLNQPFPTVPIIGPRTPEQLRDSLAAA 290
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
19-320 |
1.41e-40 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 143.89 E-value: 1.41e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 19 GAWAIGGGpWWGPTDDAESIRAIHAAIDAGINLIDTAPmyEYGKSEELVGRAIR------DRRDKVLIATKcglWHRDar 92
Cdd:cd19101 8 GMWQLSGG-HGGIRDEDAAVRAMAAYVDAGLTTFDCAD--IYGPAEELIGEFRKrlrrerDAADDVQIHTK---WVPD-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 93 gSEWFTMGSHTIRRSlrpdtirieVEESLRRLGVDRIDLYQTHWQaiEPEKTPIADTMACLMDLRAQGKIRAIGVSNATT 172
Cdd:cd19101 80 -PGELTMTRAYVEAA---------IDRSLKRLGVDRLDLVQFHWW--DYSDPGYLDAAKHLAELQEEGKIRHLGLTNFDT 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 173 ADMD-AYRAAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTgkigmDRTFGADESrnriPWFLPANR 251
Cdd:cd19101 148 ERLReILDAGVPIVSNQVQYSLLDRRPENGMAALCEDHGIKLLAYGTLAGGLLS-----EKYLGVPEP----TGPALETR 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 252 -----ARVLAMLGGWK---DLCAA-------HACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLALDTATLA 316
Cdd:cd19101 219 slqkyKLMIDEWGGWDlfqELLRTlkaiadkHGVSIANVAVRWVLDQPGVAGVIVGARNSEHIDDNVRAFSFRLDDEDRA 298
|
....
gi 1175985856 317 RMRA 320
Cdd:cd19101 299 AIDA 302
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
10-310 |
2.63e-39 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 140.55 E-value: 2.63e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 10 DMKASCVAFGAWAIGGGPWWGPT------DDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDR-RDKVLIAT 82
Cdd:cd19103 1 DKKLPKIALGTWSWGSGGAGGDQvfgnhlDEDTLKAVFDKAMAAGLNLWDTAAVYGMGASEKILGEFLKRYpREDYIIST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 83 KcglwhrdargsewFT-MGSHTirrslRPDTIRIEVEESLRRLGVDRIDLYQTHWQAIEPEKTPIadtmacLMDLRAQGK 161
Cdd:cd19103 81 K-------------FTpQIAGQ-----SADPVADMLEGSLARLGTDYIDIYWIHNPADVERWTPE------LIPLLKSGK 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 162 IRAIGVSNATTADM----DAYRAAG-ELSACQPRYSMLDRA-IEADVLPYCLRSNVAILAYSPLEQGLLTGKIGMDRTFG 235
Cdd:cd19103 137 VKHVGVSNHNLAEIkranEILAKAGvSLSAVQNHYSLLYRSsEEAGILDYCKENGITFFAYMVLEQGALSGKYDTKHPLP 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1175985856 236 ADESR----NRIpwfLPanraRVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPglTIALCGARKVAQVLENAKAGGLAL 310
Cdd:cd19103 217 EGSGRaetyNPL---LP----QLEELTAVMAEIGAKHGASIAQVAIAWAIAKG--TTPIIGVTKPHHVEDAARAASITL 286
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
16-305 |
2.01e-36 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 133.07 E-value: 2.01e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 16 VAFGAWAIGggpWWGPTDDAESIRAIHAAI-DAGINLIDTAPMYEYGKSEELVGRAIRDRRDkVLIATKcglwhrdARGs 94
Cdd:cd19075 3 IILGTMTFG---SQGRFTTAEAAAELLDAFlERGHTEIDTARVYPDGTSEELLGELGLGERG-FKIDTK-------ANP- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 95 eWFTMGshtirrsLRPDTIRIEVEESLRRLGVDRIDLYQTHwqAIEPeKTPIADTMACLMDLRAQGKIRAIGVSNATtAD 174
Cdd:cd19075 71 -GVGGG-------LSPENVRKQLETSLKRLKVDKVDVFYLH--APDR-STPLEETLAAIDELYKEGKFKEFGLSNYS-AW 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 175 MDAY-----RAAGEL--SACQPRYSMLDRAIEADVLPyCLRS-NVAILAYSPLEQGLLTGKIgmdRTFGADESRNRipwF 246
Cdd:cd19075 139 EVAEiveicKENGWVlpTVYQGMYNAITRQVETELFP-CLRKlGIRFYAYSPLAGGFLTGKY---KYSEDKAGGGR---F 211
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1175985856 247 LPAN------RAR-----VLAMLGGWKDLCAAHACTLGQLVIAWTV------AQPGLTIALcGARKVAQVLENAKA 305
Cdd:cd19075 212 DPNNalgklyRDRywkpsYFEALEKVEEAAEKEGISLAEAALRWLYhhsaldGEKGDGVIL-GASSLEQLEENLAA 286
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
14-302 |
6.52e-36 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 131.68 E-value: 6.52e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 14 SCVAFGAWAIGGgpWWGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDR-RDKVLIATKCGLWHRDAR 92
Cdd:cd19161 1 SELGLGTAGLGN--LYTAVSNADADATLDAAWDSGIRYFDTAPMYGHGLAEHRLGDFLREKpRDEFVLSTKVGRLLKPAR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 93 GSEWFTMGSHTIRRSLRP------DTIRIEVEESLRRLGVDRIDLYQTH-----WQAIEPEKTPIADTMA----CLMDLR 157
Cdd:cd19161 79 EGSVPDPNGFVDPLPFEIvydysyDGIMRSFEDSLQRLGLNRIDILYVHdigvyTHGDRKERHHFAQLMSggfkALEELK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 158 AQGKIRAIG-------VSNATT--ADMDAYRAAGelsacqpRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKI 228
Cdd:cd19161 159 KAGVIKAFGlgvnevqICLEALdeADLDCFLLAG-------RYSLLDQSAEEEFLPRCEQRGTSLVIGGVFNSGILATGT 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1175985856 229 GMDRTFGADESrnripwflPAN-RARVLAMlggwKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLEN 302
Cdd:cd19161 232 KSGAKFNYGDA--------PAEiISRVMEI----EKICDAYNVPLAAAALQFPLRHPAVASVLTGARNPAQLRQN 294
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
27-305 |
1.09e-35 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 129.60 E-value: 1.09e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 27 PWWGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDR-RDKVLIATKCGLWhrdargsewftmgshtir 105
Cdd:cd19096 13 SDDDSIDEEKAIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEALKEGpREKFYLATKLPPW------------------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 106 RSLRPDTIRIEVEESLRRLGVDRIDLYQTHW--QAIEPEKTPIADTMACLMDLRAQGKIRAIGVS-NATTADMDAYRAAG 182
Cdd:cd19096 75 SVKSAEDFRRILEESLKRLGVDYIDFYLLHGlnSPEWLEKARKGGLLEFLEKAKKEGLIRHIGFSfHDSPELLKEILDSY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 183 ELSACQPRYSMLDRAIEA--DVLPYCLRSNVAILAYSPLEQGLLTgkigmdrtfgadesrNRIPWFLpanrarvlamlgg 260
Cdd:cd19096 155 DFDFVQLQYNYLDQENQAgrPGIEYAAKKGMGVIIMEPLKGGGLA---------------NNPPEAL------------- 206
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1175985856 261 wKDLCAAhACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKA 305
Cdd:cd19096 207 -AILCGA-PLSPAEWALRFLLSHPEVTTVLSGMSTPEQLDENIAA 249
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
1-305 |
4.50e-34 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 126.94 E-value: 4.50e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 1 MHYRQIGTTDMKASCVAFGAWAIgggpwWGPTDDAESIRA-IHAAIDAGINLIDTAPMYEYGKSEELVGRAIRD---RRD 76
Cdd:cd19143 1 MEYRRLGRSGLKVSALSFGSWVT-----FGNQVDVDEAKEcMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIKElgwPRS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 77 KVLIATKCglwhrdargsEWFTMGSHTIRRSLRPDTIRIEVEESLRRLGVDRIDLYQTHwqaiEPE-KTPIADTMACLMD 155
Cdd:cd19143 76 DYVVSTKI----------FWGGGGPPPNDRGLSRKHIVEGTKASLKRLQLDYVDLVFCH----RPDpATPIEETVRAMND 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 156 LRAQGKIRAIGVSNATTAD-MDAYRAAGELSAC-----QPRYSMLDRA-IEADVLPYCLRSNVAILAYSPLEQGLLTGK- 227
Cdd:cd19143 142 LIDQGKAFYWGTSEWSAQQiEEAHEIADRLGLIppvmeQPQYNLFHRErVEVEYAPLYEKYGLGTTTWSPLASGLLTGKy 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 228 ---IGMDRTFgADESRNRIPWFLPANRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAK 304
Cdd:cd19143 222 nngIPEGSRL-ALPGYEWLKDRKEELGQEKIEKVRKLKPIAEELGCSLAQLAIAWCLKNPNVSTVITGATKVEQLEENLK 300
|
.
gi 1175985856 305 A 305
Cdd:cd19143 301 A 301
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
11-304 |
1.44e-33 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 125.51 E-value: 1.44e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 11 MKASCVAFGAWAIGGGPwwgpTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRD-------RRDKVLIATK 83
Cdd:cd19099 1 LTLSSLGLGTYRGDSDD----ETDEEYREALKAALDSGINVIDTAINYRGGRSERLIGKALREliekggiKRDEVVIVTK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 84 CGL----WHRDARGSEWFTMGSH----------TIRRSLRPDTIRIEVEESLRRLGVDRIDLYQTH---WQAIEPEKTPI 146
Cdd:cd19099 77 AGYipgdGDEPLRPLKYLEEKLGrglidvadsaGLRHCISPAYLEDQIERSLKRLGLDTIDLYLLHnpeEQLLELGEEEF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 147 ADTM----ACLMDLRAQGKIRAIGVS--NATTADMDAYR-------------AAGELSACQ----PrYSMLDRAIEAD-- 201
Cdd:cd19099 157 YDRLeeafEALEEAVAEGKIRYYGIStwDGFRAPPALPGhlsleklvaaaeeVGGDNHHFKviqlP-LNLLEPEALTEkn 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 202 --------VLPYCLRSNVAILAYSPLEQGLLTGkigmdrtfgadesRNRIPWFLPANRARVLAmlggwkdlcaahactlg 273
Cdd:cd19099 236 tvkgealsLLEAAKELGLGVIASRPLNQGQLLG-------------ELRLADLLALPGGATLA----------------- 285
|
330 340 350
....*....|....*....|....*....|.
gi 1175985856 274 QLVIAWTVAQPGLTIALCGARKVAQVLENAK 304
Cdd:cd19099 286 QRALQFARSTPGVDSALVGMRRPEHVDENLA 316
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
16-303 |
1.56e-33 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 124.78 E-value: 1.56e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 16 VAFGAWAIGGGPWWGptdDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDR-RDKVLIATKCGlwhRDARGS 94
Cdd:cd19162 3 LGLGAASLGNLARAG---EDEAAATLDAAWDAGIRYFDTAPLYGLGLSERRLGAALARHpRAEYVVSTKVG---RLLEPG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 95 EWFTMGSHTIRRSLRPDTIRIEVEESLRRLGVDRIDLYQTHwQAIEPEKTPIADTMACLMDLRAQGKIRAIGVSNATTAD 174
Cdd:cd19162 77 AAGRPAGADRRFDFSADGIRRSIEASLERLGLDRLDLVFLH-DPDRHLLQALTDAFPALEELRAEGVVGAIGVGVTDWAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 175 MDAYRAAGELSACQP--RYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLL-TGKIGMDRTFgadesrnripwFLPANR 251
Cdd:cd19162 156 LLRAARRADVDVVMVagRYTLLDRRAATELLPLCAAKGVAVVAAGVFNSGILaTDDPAGDRYD-----------YRPATP 224
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1175985856 252 aRVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENA 303
Cdd:cd19162 225 -EVLARARRLAAVCRRYGVPLPAAALQFPLRHPAVASVVVGAASPAELRDNL 275
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
3-328 |
1.68e-33 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 125.66 E-value: 1.68e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 3 YRQIGTTDMKASCVAFGAWAIGGGpwWGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDR---RDKVL 79
Cdd:PLN02587 1 LRELGSTGLKVSSVGFGASPLGSV--FGPVSEEDAIASVREAFRLGINFFDTSPYYGGTLSEKVLGKALKALgipREKYV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 80 IATKCGlwhrdaRGSEWFTMGSHTIRRSlrpdtirieVEESLRRLGVDRIDLYQTHWQAIEPEKTPIADTMACLMDLRAQ 159
Cdd:PLN02587 79 VSTKCG------RYGEGFDFSAERVTKS---------VDESLARLQLDYVDILHCHDIEFGSLDQIVNETIPALQKLKES 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 160 GKIRAIGVSNATtadMDAYR------AAGE----LSACqpRYSMLDRAIEaDVLPYCLRSNVAILAYSPLEQGLLTGKig 229
Cdd:PLN02587 144 GKVRFIGITGLP---LAIFTyvldrvPPGTvdviLSYC--HYSLNDSSLE-DLLPYLKSKGVGVISASPLAMGLLTEN-- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 230 mdrtfGADESRNRIPWFLPANRARVlamlggwkDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAgglA 309
Cdd:PLN02587 216 -----GPPEWHPAPPELKSACAAAA--------THCKEKGKNISKLALQYSLSNKDISTTLVGMNSVQQVEENVAA---A 279
|
330 340
....*....|....*....|..
gi 1175985856 310 LDTATLA---RMRADVEALGAP 328
Cdd:PLN02587 280 TELETSGideELLSEVEAILAP 301
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
3-305 |
2.45e-33 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 124.82 E-value: 2.45e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 3 YRQIGTTDMKASCVAFGAWAIGGGpwwgpTDDAESIRA-IHAAIDAGINLIDTAPMY--EYGKSEELVGRAIRDR----R 75
Cdd:cd19151 2 YNRCGRSGLKLPAISLGLWHNFGD-----VDRYENSRAmLRRAFDLGITHFDLANNYgpPPGSAEENFGRILKEDlkpyR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 76 DKVLIATKCGLWHRDARGSEWftmGShtiRRSLRPdtiriEVEESLRRLGVDRIDLYQTHwqAIEPEkTPIADTMACLMD 155
Cdd:cd19151 77 DELIISTKAGYTMWPGPYGDW---GS---KKYLIA-----SLDQSLKRMGLDYVDIFYHH--RPDPE-TPLEETMGALDQ 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 156 LRAQGKIRAIGVSNATTADM-DAYRAAGEL-SAC---QPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTgkigm 230
Cdd:cd19151 143 IVRQGKALYVGISNYPPEEArEAAAILKDLgTPClihQPKYSMFNRWVEEGLLDVLEEEGIGCIAFSPLAQGLLT----- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 231 DRTFGA--DESRNRIPW-FLPANR--ARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKA 305
Cdd:cd19151 218 DRYLNGipEDSRAAKGSsFLKPEQitEEKLAKVRRLNEIAQARGQKLAQMALAWVLRNKRVTSVLIGASKPSQIEDAVGA 297
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
17-320 |
3.71e-33 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 123.14 E-value: 3.71e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 17 AFGAW--AIGGGPWwgPTDDAESIRAIHAAIDAGINLIDTAPMYEygkSEELVGRAIRD---RRDKVLIATKCglWHRDa 91
Cdd:cd19140 3 VNGVRipALGLGTY--PLTGEECTRAVEHALELGYRHIDTAQMYG---NEAQVGEAIAAsgvPRDELFLTTKV--WPDN- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 92 rgsewftmgshtirrsLRPDTIRIEVEESLRRLGVDRIDLYQTHWqaiEPEKTPIADTMACLMDLRAQGKIRAIGVSNAT 171
Cdd:cd19140 75 ----------------YSPDDFLASVEESLRKLRTDYVDLLLLHW---PNKDVPLAETLGALNEAQEAGLARHIGVSNFT 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 172 TADMDAYRAAGE--LSACQPRYS-MLDraiEADVLPYCLRSNVAILAYSPLEQglltGKIGMDRTFGadesrnripwflp 248
Cdd:cd19140 136 VALLREAVELSEapLFTNQVEYHpYLD---QRKLLDAAREHGIALTAYSPLAR----GEVLKDPVLQ------------- 195
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1175985856 249 anrarvlamlggwkDLCAAHACTLGQLVIAWTVAQPGLtIALCGARKVAQVLENAKAGGLALDTATLARMRA 320
Cdd:cd19140 196 --------------EIGRKHGKTPAQVALRWLLQQEGV-AAIPKATNPERLEENLDIFDFTLSDEEMARIAA 252
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
22-319 |
1.10e-32 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 121.61 E-value: 1.10e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWWGPTDDAesIRAIHAAIDAGINLIDTAPMYEygkSEELVGRAIRD---RRDKVLIATKcgLWhrdargsewft 98
Cdd:cd19073 3 ALGLGTWQLRGDDC--ANAVKEALELGYRHIDTAEIYN---NEAEVGEAIAEsgvPREDLFITTK--VW----------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 99 mgshtiRRSLRPDTIRIEVEESLRRLGVDRIDLYQTHWqaiePEKT-PIADTMACLMDLRAQGKIRAIGVSNATTADM-D 176
Cdd:cd19073 65 ------RDHLRPEDLKKSVDRSLEKLGTDYVDLLLIHW----PNPTvPLEETLGALKELKEAGKVKSIGVSNFTIELLeE 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 177 AYRAAGELSAC-QPRYS-MLDRaieADVLPYCLRSNVAILAYSPLEQglltGKIGMDRTFgadesrnripwflpanrarv 254
Cdd:cd19073 135 ALDISPLPIAVnQVEFHpFLYQ---AELLEYCRENDIVITAYSPLAR----GEVLRDPVI-------------------- 187
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1175985856 255 lamlggwKDLCAAHACTLGQLVIAWTVAQPglTIALCGARKVAQVLENAKAGGLALDTATLARMR 319
Cdd:cd19073 188 -------QEIAEKYDKTPAQVALRWLVQKG--IVVIPKASSEDHLKENLAIFDWELTSEDVAKID 243
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
16-313 |
1.64e-32 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 122.72 E-value: 1.64e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 16 VAFGAWAIGGGpwWGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDR-RDKVLIATKCGLWHRDARGS 94
Cdd:cd19152 3 LGFGTAPLGNL--YEAVSDEEAKATLVAAWDLGIRYFDTAPWYGAGLSEERLGAALRELgREDYVISTKVGRLLVPLQEV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 95 EWFTMGSHTIRRSLRP------DTIRIEVEESLRRLGVDRIDL-------YQTHWQA-IEPEKTPIADTMACLMDLRAQG 160
Cdd:cd19152 81 EPTFEPGFWNPLPFDAvfdysyDGILRSIEDSLQRLGLSRIDLlsihdpdEDLAGAEsDEHFAQAIKGAFRALEELREEG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 161 KIRAIGV-SNATTADMDAYRAA---GELSACqpRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKIGMDRTFGA 236
Cdd:cd19152 161 VIKAIGLgVNDWEVILRILEEAdldWVMLAG--RYTLLDHSAARELLPECEKRGVKVVNAGPFNSGFLAGGDNFDYYEYG 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1175985856 237 DESRNRIPWflpanRARvlamlggWKDLCAAHACTLGQLVIAWTVAQPGL-TIALcGARKVAQVLENAKAGGLALDTA 313
Cdd:cd19152 239 PAPPELIAR-----RDR-------IEALCEQHGVSLAAAALQFALAPPAVaSVAP-GASSPERVEENVALLATEIPAA 303
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
30-305 |
1.01e-31 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 119.55 E-value: 1.01e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 30 GPTDDAESIRAIHAAIDAGINLIDTAPMyeYGKSEELVGRAIRdRRDKVLIATKC-GLWHRDARGSEWftmgshtirrsl 108
Cdd:cd19097 21 GKPSEKEAKKILEYALKAGINTLDTAPA--YGDSEKVLGKFLK-RLDKFKIITKLpPLKEDKKEDEAA------------ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 109 rpdtIRIEVEESLRRLGVDRIDLYQTHWQAIEPEKTPiaDTMACLMDLRAQGKIRAIGVSNATTADMDAYRAAGELSACQ 188
Cdd:cd19097 86 ----IEASVEASLKRLKVDSLDGLLLHNPDDLLKHGG--KLVEALLELKKEGLIRKIGVSVYSPEELEKALESFKIDIIQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 189 PRYSMLD-RAIEADVLPYCLRSNVAILAYSPLEQGLLTgkigMDrtfgadesRNRIPWFLPANRARVLAmlggWKDLCAA 267
Cdd:cd19097 160 LPFNILDqRFLKSGLLAKLKKKGIEIHARSVFLQGLLL----ME--------PDKLPAKFAPAKPLLKK----LHELAKK 223
|
250 260 270
....*....|....*....|....*....|....*...
gi 1175985856 268 HACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKA 305
Cdd:cd19097 224 LGLSPLELALGFVLSLPEIDKIVVGVDSLEQLKEIIAA 261
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
22-318 |
2.68e-31 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 117.97 E-value: 2.68e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWWGPTDDAEsiRAIHAAIDAGINLIDTAPMYeygKSEELVGRAIRD---RRDKVLIATKcgLWHRDargsewft 98
Cdd:cd19071 3 LIGLGTYKLKPEETA--EAVLAALEAGYRHIDTAAAY---GNEAEVGEAIREsgvPREELFITTK--LWPTD-------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 99 mgshtirrsLRPDTIRIEVEESLRRLGVDRIDLYQTHW---QAIEPEKTPIADTMACLMDLRAQGKIRAIGVSNATTADM 175
Cdd:cd19071 68 ---------HGYERVREALEESLKDLGLDYLDLYLIHWpvpGKEGGSKEARLETWRALEELVDEGLVRSIGVSNFNVEHL 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 176 DA-YRAAGELSAC-QPRYSML--DRAIEAdvlpYCLRSNVAILAYSPLEQGlltgkigmdrtfgadesrNRIPWFLPAnr 251
Cdd:cd19071 139 EElLAAARIKPAVnQIELHPYlqQKELVE----FCKEHGIVVQAYSPLGRG------------------RRPLLDDPV-- 194
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1175985856 252 arvlamlggWKDLCAAHACTLGQLVIAWTVaQPGlTIALCGARKVAQVLENAKAGGLALDTATLARM 318
Cdd:cd19071 195 ---------LKEIAKKYGKTPAQVLLRWAL-QRG-VVVIPKSSNPERIKENLDVFDFELSEEDMAAI 250
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
1-320 |
1.44e-30 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 118.42 E-value: 1.44e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 1 MHYRQIGTTDMKASCVAFGAWAIGGgpwwgPTDDAESIRAIHAAIDAGINLIDTAPMYEY-------GKSEELVGRAIRD 73
Cdd:PRK10625 1 MQYHRIPHSSLEVSTLGLGTMTFGE-----QNSEADAHAQLDYAVAQGINLIDVAEMYPVpprpetqGLTETYIGNWLAK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 74 R--RDKVLIATKCGlwhRDARGSEwftmgsHTIR--RSLRPDTIRIEVEESLRRLGVDRIDLYQTHWQAIE--------- 140
Cdd:PRK10625 76 RgsREKLIIASKVS---GPSRNND------KGIRpnQALDRKNIREALHDSLKRLQTDYLDLYQVHWPQRPtncfgklgy 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 141 --PEKTPIA---DTMACLMDLRAQGKIRAIGVSNATTADMDAYRAAGE------LSACQPRYSMLDRAIEADVLPYCLRS 209
Cdd:PRK10625 147 swTDSAPAVsllETLDALAEQQRAGKIRYIGVSNETAFGVMRYLHLAEkhdlprIVTIQNPYSLLNRSFEVGLAEVSQYE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 210 NVAILAYSPLEQGLLTGKIgmdrTFGADESRNRIPWFLPANR---ARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGL 286
Cdd:PRK10625 227 GVELLAYSCLAFGTLTGKY----LNGAKPAGARNTLFSRFTRysgEQTQKAVAAYVDIAKRHGLDPAQMALAFVRRQPFV 302
|
330 340 350
....*....|....*....|....*....|....
gi 1175985856 287 TIALCGARKVAQVLENAKAGGLALDTATLARMRA 320
Cdd:PRK10625 303 ASTLLGATTMEQLKTNIESLHLTLSEEVLAEIEA 336
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
3-305 |
5.42e-27 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 107.93 E-value: 5.42e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 3 YRQIGTTDMKASCVAFGAWAIGGGpwwgpTDDAESIRAI-HAAIDAGINLIDTAPMY--EYGKSEELVGRAIRD----RR 75
Cdd:cd19150 2 YRRCGKSGLKLPALSLGLWHNFGD-----DTPLETQRAIlRTAFDLGITHFDLANNYgpPPGSAEENFGRILREdfagYR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 76 DKVLIATKCGLWHRDARGSEWftmGShtiRRSLRPdtiriEVEESLRRLGVDRIDLYQTHwqAIEPEkTPIADTMACLMD 155
Cdd:cd19150 77 DELIISTKAGYDMWPGPYGEW---GS---RKYLLA-----SLDQSLKRMGLDYVDIFYSH--RFDPD-TPLEETMGALDH 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 156 LRAQGKIRAIGVSN---ATTADMDAY--RAAGELSACQPRYSMLDRAIEADVLPYCLRSN-VAILAYSPLEQGLLTGKI- 228
Cdd:cd19150 143 AVRSGKALYVGISSyspERTREAAAIlrELGTPLLIHQPSYNMLNRWVEESGLLDTLQELgVGCIAFTPLAQGLLTDKYl 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1175985856 229 -GMDRTFGADESRNRIPWFL-PANRARVLAMlggwKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKA 305
Cdd:cd19150 223 nGIPEGSRASKERSLSPKMLtEANLNSIRAL----NEIAQKRGQSLAQMALAWVLRDGRVTSALIGASRPEQLEENVGA 297
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
23-224 |
1.39e-26 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 105.60 E-value: 1.39e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 23 IGGGPWWGPTDDaESIRAIHAAIDAGINLIDTAPMYeygKSEELVGRAIRDR---RDKVLIATKcgLWHRDARGsewftm 99
Cdd:cd19126 12 LGLGVFQTPDGD-ETERAVQTALENGYRSIDTAAIY---KNEEGVGEAIRESgvpREELFVTTK--LWNDDQRA------ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 100 gshtiRRSLRPdtirieVEESLRRLGVDRIDLYQTHWqaiePEKTPIADTMACLMDLRAQGKIRAIGVSNATTADMDAYR 179
Cdd:cd19126 80 -----RRTEDA------FQESLDRLGLDYVDLYLIHW----PGKDKFIDTWKALEKLYASGKVKAIGVSNFQEHHLEELL 144
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1175985856 180 AAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLL 224
Cdd:cd19126 145 AHADVVPAVNQVEFHPYLTQKELRGYCKSKGIVVEAWSPLGQGGL 189
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
23-222 |
1.65e-26 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 105.15 E-value: 1.65e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 23 IGGGPWwgPTDDAESIRAIHAAIDAGINLIDTAPMYeygKSEELVGRAIRD---RRDKVLIATKcgLWHRDARGsewftm 99
Cdd:cd19131 13 LGLGVW--QVSNDEAASAVREALEVGYRSIDTAAIY---GNEEGVGKAIRAsgvPREELFITTK--LWNSDQGY------ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 100 gshtirrslrpDTIRIEVEESLRRLGVDRIDLYQTHWQAiePEKTPIADTMACLMDLRAQGKIRAIGVSNATTADMDayR 179
Cdd:cd19131 80 -----------DSTLRAFDESLRKLGLDYVDLYLIHWPV--PAQDKYVETWKALIELKKEGRVKSIGVSNFTIEHLQ--R 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1175985856 180 AAGELSA--------CQPRysMLDRAIEAdvlpYCLRSNVAILAYSPLEQG 222
Cdd:cd19131 145 LIDETGVvpvvnqieLHPR--FQQRELRA----FHAKHGIQTESWSPLGQG 189
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
8-310 |
6.32e-25 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 102.50 E-value: 6.32e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 8 TTDMKASCVAFGAWAIGGGpW---WGPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGR--AIRDRRDKVLIAT 82
Cdd:cd19146 6 TAGVRVSPLCLGAMSFGEA-WksmMGECDKETAFKLLDAFYEQGGNFIDTANNYQGEESERWVGEwmASRGNRDEMVLAT 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 83 KCGLWHRdaRGSE----WFTMGSHTirRSLrpdtiRIEVEESLRRLGVDRIDLYQTHWQAIEpekTPIADTMACLMDLRA 158
Cdd:cd19146 85 KYTTGYR--RGGPikikSNYQGNHA--KSL-----RLSVEASLKKLQTSYIDILYVHWWDYT---TSIPELMQSLNHLVA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 159 QGKIRAIGVSNA---TTADMDAY-RAAG--ELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQglltGKIGMDR 232
Cdd:cd19146 153 AGKVLYLGVSDTpawVVSKANAYaRAHGltQFVVYQGHWSAAFRDFERDILPMCEAEGMALAPWGVLGQ----GQFRTEE 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1175985856 233 TFGADESRNRIPWFLPANRARVLAMLggwKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLAL 310
Cdd:cd19146 229 EFKRRGRSGRKGGPQTEKERKVSEKL---EKVAEEKGTAITSVALAYVMHKAPYVFPIVGGRKVEHLKGNIEALGISL 303
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
16-219 |
8.22e-25 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 101.15 E-value: 8.22e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 16 VAFGAwaigGGPWWGPTDDA---ESIRAIHAAIDAGINLIDTAPMYeygKSEELVGRAIRD---RRDKVLIATKCGLWHR 89
Cdd:cd19120 7 IAFGT----GTAWYKSGDDDiqrDLVDSVKLALKAGFRHIDTAEMY---GNEKEVGEALKEsgvPREDLFITTKVSPGIK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 90 DARGSewftmgshtirrslrpdtirieVEESLRRLGVDRIDLYQTHWQAIEPEKTP-IADTMACLMDLRAQGKIRAIGVS 168
Cdd:cd19120 80 DPREA----------------------LRKSLAKLGVDYVDLYLIHSPFFAKEGGPtLAEAWAELEALKDAGLVRSIGVS 137
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1175985856 169 NATTADMDA-YRAAGELSAC-QPRYSMLDRAIEADVLPYCLRSNVAILAYSPL 219
Cdd:cd19120 138 NFRIEDLEElLDTAKIKPAVnQIEFHPYLYPQQPALLEYCREHGIVVSAYSPL 190
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
22-320 |
1.61e-24 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 99.74 E-value: 1.61e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWwGPTDDAeSIRAIHAAIDAGINLIDTAPMYEygkSEELVGRAIRD---RRDKVLIATKCglwhrdargseWFT 98
Cdd:cd19139 3 AFGLGTF-RLKDDV-VIDSVRTALELGYRHIDTAQIYD---NEAAVGQAIAEsgvPRDELFITTKI-----------WID 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 99 mgshtirrSLRPDTIRIEVEESLRRLGVDRIDLYQTHWQAIEPEkTPIADTMACLMDLRAQGKIRAIGVSNATTADMDAY 178
Cdd:cd19139 67 --------NLSKDKLLPSLEESLEKLRTDYVDLTLIHWPSPNDE-VPVEEYIGALAEAKEQGLTRHIGVSNFTIALLDEA 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 179 RAA---GELSACQPRYS--MLDRAIEAdvlpYCLRSNVAILAYSPLEQglltGKIGMDRTFgadesrnripwflpanrar 253
Cdd:cd19139 138 IAVvgaGAIATNQIELSpyLQNRKLVA----HCKQHGIHVTSYMTLAY----GKVLDDPVL------------------- 190
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1175985856 254 vlamlggwKDLCAAHACTLGQLVIAWTVAQPGLTIAlcGARKVAQVLENAKAGGLALDTATLARMRA 320
Cdd:cd19139 191 --------AAIAERHGATPAQIALAWAMARGYAVIP--SSTKREHLRSNLLALDLTLDADDMAAIAA 247
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
1-323 |
9.58e-24 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 99.68 E-value: 9.58e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 1 MHYRQIGTTDMKASCVAFGAWAIgggpwWGPTDDAESIRAI-HAAIDAGINLIDTAPMY--EYGKSEELVGRAIRDR--- 74
Cdd:PRK09912 13 MQYRYCGKSGLRLPALSLGLWHN-----FGHVNALESQRAIlRKAFDLGITHFDLANNYgpPPGSAEENFGRLLREDfaa 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 75 -RDKVLIATKCG--LWHRdargsewfTMGSHTIRRSLRPdtiriEVEESLRRLGVDRIDLYQTHWQaiePEKTPIADTMA 151
Cdd:PRK09912 88 yRDELIISTKAGydMWPG--------PYGSGGSRKYLLA-----SLDQSLKRMGLEYVDIFYSHRV---DENTPMEETAS 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 152 CLMDLRAQGKIRAIGVSN---ATTADM-DAYRAAG-ELSACQPRYSMLDRAIEADVLPYCLRSN-VAILAYSPLEQGLLT 225
Cdd:PRK09912 152 ALAHAVQSGKALYVGISSyspERTQKMvELLREWKiPLLIHQPSYNLLNRWVDKSGLLDTLQNNgVGCIAFTPLAQGLLT 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 226 GKI--------GMDRTfgADESRNRIPWFLPANRARVLAMLggwKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVA 297
Cdd:PRK09912 232 GKYlngipqdsRMHRE--GNKVRGLTPKMLTEANLNSLRLL---NEMAQQRGQSMAQMALSWLLKDERVTSVLIGASRAE 306
|
330 340
....*....|....*....|....*..
gi 1175985856 298 QVLENAKA-GGLALDTATLARMRADVE 323
Cdd:PRK09912 307 QLEENVQAlNNLTFSTEELAQIDQHIA 333
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
8-310 |
2.50e-23 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 97.97 E-value: 2.50e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 8 TTDMKASCVAFGAWAIGGGpwW----GPTDDAESIRAIHAAIDAGINLIDTAPMYEYGKSEELVGR--AIRDRRDKVLIA 81
Cdd:cd19147 5 TAGIRVSPLILGAMSIGDA--WsgfmGSMDKEQAFELLDAFYEAGGNFIDTANNYQDEQSETWIGEwmKSRKNRDQIVIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 82 TKCGLWHRDARGSEWFTM---GSHtiRRSLrpdtiRIEVEESLRRLGVDRIDLYQTHWQAIepeKTPIADTMACLMDLRA 158
Cdd:cd19147 83 TKFTTDYKAYEVGKGKAVnycGNH--KRSL-----HVSVRDSLRKLQTDWIDILYVHWWDY---TTSIEEVMDSLHILVQ 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 159 QGKIRAIGVSNA---TTADMDAY-RAAGE--LSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGKIGMDR 232
Cdd:cd19147 153 QGKVLYLGVSDTpawVVSAANYYaTAHGKtpFSVYQGRWNVLNRDFERDIIPMARHFGMALAPWDVLGGGKFQSKKAVEE 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 233 TFGADESRNRipWFLPANRARV-LAMLGGWKDLCAAHAC-TLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLAL 310
Cdd:cd19147 233 RKKNGEGLRS--FVGGTEQTPEeVKISEALEKVAEEHGTeSVTAIALAYVRSKAPNVFPLVGGRKIEHLKDNIEALSIKL 310
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
16-320 |
2.57e-23 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 96.93 E-value: 2.57e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 16 VAFGAWAIGGgpwwgpTDDAEsiRAIHAAIDAGINLIDTAPMYeygKSEELVGRAIRD-------RRDKVLIATKcgLWH 88
Cdd:cd19136 4 LGLGTFRLRG------EEEVR--QAVDAALKAGYRLIDTASVY---RNEADIGKALRDllpkyglSREDIFITSK--LAP 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 89 RDargsewftMGSHTIRRSlrpdtirieVEESLRRLGVDRIDLYQTHWQAI--EPEKTPI-----ADTMACLMDLRAQGK 161
Cdd:cd19136 71 KD--------QGYEKARAA---------CLGSLERLGTDYLDLYLIHWPGVqgLKPSDPRnaelrRESWRALEDLYKEGK 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 162 IRAIGVSNATTADMDayraagELSA------------CQPRYsmldraIEADVLPYCLRSNVAILAYSPLEQGLLtgkig 229
Cdd:cd19136 134 LRAIGVSNYTVRHLE------ELLKycevppavnqveFHPHL------VQKELLKFCKDHGIHLQAYSSLGSGDL----- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 230 mdrtfgadesrnripwfLPANRARVLAMlggwkdlCAAHACTLGQLVIAWTVaQPGltialCG----ARKVAQVLENAKA 305
Cdd:cd19136 197 -----------------RLLEDPTVLAI-------AKKYGRTPAQVLLRWAL-QQG-----IGvipkSTNPERIAENIKV 246
|
330
....*....|....*
gi 1175985856 306 GGLALDTATLARMRA 320
Cdd:cd19136 247 FDFELSEEDMAELNA 261
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
29-224 |
2.71e-22 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 94.12 E-value: 2.71e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 29 WGPTDDAESIRAIHAAIDAGINLIDTAPMYeygKSEELVGRAIRD---RRDKVLIATKcgLWHRDaRGSEwftmgshtir 105
Cdd:cd19156 17 WRVQDGAEAENAVKWAIEAGYRHIDTAAIY---KNEEGVGQGIREsgvPREEVFVTTK--LWNSD-QGYE---------- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 106 rslrpDTIRiEVEESLRRLGVDRIDLYQTHWqaiePEKTPIADTMACLMDLRAQGKIRAIGVSNattadMDAYRAAGELS 185
Cdd:cd19156 81 -----STLA-AFEESLEKLGLDYVDLYLIHW----PVKGKFKDTWKAFEKLYKEKKVRAIGVSN-----FHEHHLEELLK 145
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1175985856 186 ACQPRySMLDRaIE-------ADVLPYCLRSNVAILAYSPLEQGLL 224
Cdd:cd19156 146 SCKVA-PMVNQ-IElhplltqEPLRKFCKEKNIAVEAWSPLGQGKL 189
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
1-305 |
6.93e-22 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 93.95 E-value: 6.93e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 1 MHYRQIGTTDMKASCVAFGAWAIGGGPWwgpTDD-AESIRAIhaAIDAGINLIDTAPMYEYGKSEELVGRAIRD---RRD 76
Cdd:cd19159 1 MKYRNLGKSGLRVSCLGLGTWVTFGGQI---SDEvAERLMTI--AYESGVNLFDTAEVYAAGKAEVILGSIIKKkgwRRS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 77 KVLIATKCglwhrdargsewFTMGSHTIRRSLRPDTIRIEVEESLRRLGVDRIDLYqthwQAIEPE-KTPIADTMACLMD 155
Cdd:cd19159 76 SLVITTKL------------YWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVV----FANRPDsNTPMEEIVRAMTH 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 156 LRAQGKIRAIGVSNATTAD-MDAYRAAGELSACQP-----RYSMLDR-AIEADVLPYCLRSNVAILAYSPLEQGLLTGKI 228
Cdd:cd19159 140 VINQGMAMYWGTSRWSAMEiMEAYSVARQFNMIPPvceqaEYHLFQReKVEVQLPELYHKIGVGAMTWSPLACGIISGKY 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 229 GMDRTFGADESRNRIPWFlpanRARVLAMLG-----GWKDL---CAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVL 300
Cdd:cd19159 220 GNGVPESSRASLKCYQWL----KERIVSEEGrkqqnKLKDLspiAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLI 295
|
....*
gi 1175985856 301 ENAKA 305
Cdd:cd19159 296 ENLGA 300
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
41-224 |
8.28e-22 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 92.77 E-value: 8.28e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 41 IHAAIDAGINLIDTAPMYeygKSEELVGRAIRD---RRDKVLIATKcgLWHRDargsewftMGSHTIRRSLrpdtiriev 117
Cdd:cd19135 32 VYALKECGYRHIDTAKRY---GCEELLGKAIKEsgvPREDLFLTTK--LWPSD--------YGYESTKQAF--------- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 118 EESLRRLGVDRIDLYQTHW-QAIEPEKTP---IADTMACLMDLRAQGKIRAIGVSNATTADMDAYRAAGEL--SACQPRY 191
Cdd:cd19135 90 EASLKRLGVDYLDLYLLHWpDCPSSGKNVketRAETWRALEELYDEGLCRAIGVSNFLIEHLEQLLEDCSVvpHVNQVEF 169
|
170 180 190
....*....|....*....|....*....|...
gi 1175985856 192 SMLDRaiEADVLPYCLRSNVAILAYSPLEQGLL 224
Cdd:cd19135 170 HPFQN--PVELIEYCRDNNIVFEGYCPLAKGKA 200
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
1-305 |
2.65e-21 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 92.46 E-value: 2.65e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 1 MHYRQIGTTDMKASCVAFGAWAIGGGPWwgpTDD-AESIRAIhaAIDAGINLIDTAPMYEYGKSEELVGRAIRD---RRD 76
Cdd:cd19158 1 QFYRNLGKSGLRVSCLGLGTWVTFGGQI---TDEmAEHLMTL--AYDNGINLFDTAEVYAAGKAEVVLGNIIKKkgwRRS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 77 KVLIATKCglwhrdargsewFTMGSHTIRRSLRPDTIRIEVEESLRRLGVDRIDLYQthwqAIEPE-KTPIADTMACLMD 155
Cdd:cd19158 76 SLVITTKI------------FWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVF----ANRPDpNTPMEETVRAMTH 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 156 LRAQGKIRAIGVSNATTAD-MDAYRAAGELSACQP-----RYSMLDR-AIEADVLPYCLRSNVAILAYSPLEQGLLTGKI 228
Cdd:cd19158 140 VINQGMAMYWGTSRWSSMEiMEAYSVARQFNLIPPiceqaEYHMFQReKVEVQLPELFHKIGVGAMTWSPLACGIVSGKY 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 229 GMDRTFGADESRNRIPWF----LPANRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAK 304
Cdd:cd19158 220 DSGIPPYSRASLKGYQWLkdkiLSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG 299
|
.
gi 1175985856 305 A 305
Cdd:cd19158 300 A 300
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
18-169 |
4.05e-20 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 88.02 E-value: 4.05e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 18 FGAWAIgggpwwgpTDDAESIRAIHAAIDAGINLIDTAPMYeygKSEELVGRAIRD---RRDKVLIATKcgLWHRDargs 94
Cdd:cd19133 14 FGVFQI--------PDPEECERAVLEAIKAGYRLIDTAAAY---GNEEAVGRAIKKsgiPREELFITTK--LWIQD---- 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1175985856 95 ewftMGSHTIRRSlrpdtirieVEESLRRLGVDRIDLYQTHWQAIEPEKTPIAdtmacLMDLRAQGKIRAIGVSN 169
Cdd:cd19133 77 ----AGYEKAKKA---------FERSLKRLGLDYLDLYLIHQPFGDVYGAWRA-----MEELYKEGKIRAIGVSN 133
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
27-222 |
4.06e-20 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 88.22 E-value: 4.06e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 27 PWWG-----PTDDAESIRAIHAAIDAGINLIDTAPMYeygKSEELVGRAIRDR---RDKVLIATKcgLWHRDaRGSEwft 98
Cdd:cd19157 11 PWLGlgvfkVEEGSEVVNAVKTALKNGYRSIDTAAIY---GNEEGVGKGIKESgipREELFITSK--VWNAD-QGYD--- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 99 mgshtirrslrpDTIRiEVEESLRRLGVDRIDLYQTHWqaiePEKTPIADTMACLMDLRAQGKIRAIGVSNATTADMDAY 178
Cdd:cd19157 82 ------------STLK-AFEASLERLGLDYLDLYLIHW----PVKGKYKETWKALEKLYKDGRVRAIGVSNFQVHHLEDL 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1175985856 179 RAAGELSA------CQPRYSmldraiEADVLPYCLRSNVAILAYSPLEQG 222
Cdd:cd19157 145 LADAEIVPmvnqveFHPRLT------QKELRDYCKKQGIQLEAWSPLMQG 188
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
16-219 |
4.11e-20 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 88.49 E-value: 4.11e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 16 VAFGAWAIGggpwwgptDDAESIRAIHAAIDAGINLIDTAPMYEygkSEELVGRAIRD-------RRDKVLIATKcgLWh 88
Cdd:cd19116 14 IALGTWKLK--------DDEGVRQAVKHAIEAGYRHIDTAYLYG---NEAEVGEAIREkiaegvvKREDLFITTK--LW- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 89 rdargsewftmGSHTIRRSLRPdtiriEVEESLRRLGVDRIDLYQTHW-------------QAIEPEKTPIADTMACLMD 155
Cdd:cd19116 80 -----------NSYHEREQVEP-----ALRESLKRLGLDYVDLYLIHWpvafkenndsesnGDGSLSDIDYLETWRGMED 143
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1175985856 156 LRAQGKIRAIGVSNATTADMDAYraageLSACQPRYSMLDraIE-------ADVLPYCLRSNVAILAYSPL 219
Cdd:cd19116 144 LVKLGLTRSIGVSNFNSEQINRL-----LSNCNIKPAVNQ--IEvhptltqEKLVAYCQSNGIVVMAYSPF 207
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
22-169 |
5.22e-20 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 87.71 E-value: 5.22e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWwgPTDDAESIRAIHAAIDAGINLIDTAPMYEygkSEELVGRAIRDR---RDKVLIATKcgLWHRDARGSEwft 98
Cdd:cd19132 9 AIGFGTY--PLKGDEGVEAVVAALQAGYRLLDTAFNYE---NEGAVGEAVRRSgvpREELFVTTK--LPGRHHGYEE--- 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1175985856 99 mgshtIRRSLrpdtirievEESLRRLGVDRIDLYQTHWQAiePEKTPIADTMACLMDLRAQGKIRAIGVSN 169
Cdd:cd19132 79 -----ALRTI---------EESLYRLGLDYVDLYLIHWPN--PSRDLYVEAWQALIEAREEGLVRSIGVSN 133
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
1-298 |
5.83e-20 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 88.68 E-value: 5.83e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 1 MHYRQIGTTDMKASCVAFGAWAIGGGPWwgPTDDAESIraIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDR---RDK 77
Cdd:cd19142 1 LKYRNLGKSGLRVSNVGLGTWSTFSTAI--SEEQAEEI--VTLAYENGINYFDTSDAFTSGQAETELGRILKKKgwkRSS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 78 VLIATKCgLWHRDARGsewftmgshtirRSLRPDTIRIEVEESLRRLGVDRIDLYQTHwqaiepektpIADTMaCLMD-- 155
Cdd:cd19142 77 YIVSTKI-YWSYGSEE------------RGLSRKHIIESVRASLRRLQLDYIDIVIIH----------KADPM-CPMEev 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 156 LRA------QGKIRAIGVSNATTAD-MDAYRAAGELSaC------QPRYSMLDR-AIEADVLPYCLRSNVAILAYSPLEQ 221
Cdd:cd19142 133 VRAmsylidNGLIMYWGTSRWSPVEiMEAFSIARQFN-CptpiceQSEYHMFCReKMELYMPELYNKVGVGLITWSPLSL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 222 GLLTGKIGMDR---TFGADESRNRIPWFLPANRA----RVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGAR 294
Cdd:cd19142 212 GLDPGISEETRrlvTKLSFKSSKYKVGSDGNGIHeetrRASHKLRELSLIAERLGCDLTQLLIAWSLKNENVQCVLIGAS 291
|
....
gi 1175985856 295 KVAQ 298
Cdd:cd19142 292 SLEQ 295
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
3-305 |
6.55e-20 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 88.27 E-value: 6.55e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 3 YRQIGTTDMKASCVAFGAWAIGGGPWwgpTDD-AESIraIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRD---RRDKV 78
Cdd:cd19141 2 YRNLGKSGLRVSCLGLGTWVTFGSQI---SDEvAEEL--VTLAYENGINLFDTAEVYAAGKAEIVLGKILKKkgwRRSSY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 79 LIATKCglwhrdargsewFTMGSHTIRRSLRPDTIRIEVEESLRRLGVDRIDLYqthwQAIEPE-KTPIADTMACLMDLR 157
Cdd:cd19141 77 VITTKI------------FWGGKAETERGLSRKHIIEGLKASLERLQLEYVDIV----FANRPDpNTPMEEIVRAFTHVI 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 158 AQGKIRAIGVSNATTAD-MDAYRAAGEL-----SACQPRYSMLDRAIEADVLPYCL-RSNVAILAYSPLEQGLLTGKIGM 230
Cdd:cd19141 141 NQGMAMYWGTSRWSAMEiMEAYSVARQFnlippIVEQAEYHLFQREKVEMQLPELFhKIGVGAMTWSPLACGILSGKYDD 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1175985856 231 DRTFGADESRNRIPWF----LPANRARVLAMLGGWKDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKA 305
Cdd:cd19141 221 GVPEYSRASLKGYQWLkekiLSEEGRRQQAKLKELQIIADRLGCTLPQLAIAWCLKNEGVSSVLLGASSTEQLYENLQA 299
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
4-305 |
7.47e-19 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 85.28 E-value: 7.47e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 4 RQIGTTDMKASCVAFGAWAIGGGPWWGP-TDDAESIraIHAAIDAGINLIDTAPMYEYGKSEELVGRAIRDR---RDKVL 79
Cdd:cd19153 3 ETLEIALGNVSPVGLGTAALGGVYGDGLeQDEAVAI--VAEAFAAGINHFDTSPYYGAESSEAVLGKALAALqvpRSSYT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 80 IATKCGlwhrdaRGSEwftmGSHTIRRslrpDTIRIEVEESLRRLGVDRIDLYQTHWQAIEPEKTPIADTMACLMDLRAQ 159
Cdd:cd19153 81 VATKVG------RYRD----SEFDYSA----ERVRASVATSLERLHTTYLDVVYLHDIEFVDYDTLVDEALPALRTLKDE 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 160 GKIRAIGVSNA---TTADMDAYRAAGELSACQP--RYSMLDRAIEADvLPYCLRSN-VAILAYSPLEQGLLTgkigmdrt 233
Cdd:cd19153 147 GVIKRIGIAGYpldTLTRATRRCSPGSLDAVLSycHLTLQDARLESD-APGLVRGAgPHVINASPLSMGLLT-------- 217
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1175985856 234 fgadeSRNRIPWFlPAN---RARVLAMLGgwkdLCAAHACTLGQLVIAWTVA-QPGLTIALCGARKVAQVLENAKA 305
Cdd:cd19153 218 -----SQGPPPWH-PASgelRHYAAAADA----VCASVEASLPDLALQYSLAaHAGVGTVLLGPSSLAQLRSMLAA 283
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
22-176 |
8.05e-19 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 84.52 E-value: 8.05e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWwgPTDDAESIRAIHAAIDAGINLIDTAPMYeygKSEELVGRAIRDR---RDKVLIATKcgLWHRDargsEWFT 98
Cdd:cd19134 13 VIGLGVG--ELSDDEAERSVSAALEAGYRLIDTAAAY---GNEAAVGRAIAASgipRGELFVTTK--LATPD----QGFT 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1175985856 99 MGSHTIRRslrpdtirieveeSLRRLGVDRIDLYQTHWQAiePEKTPIADTMACLMDLRAQGKIRAIGVSNATTADMD 176
Cdd:cd19134 82 ASQAACRA-------------SLERLGLDYVDLYLIHWPA--GREGKYVDSWGGLMKLREEGLARSIGVSNFTAEHLE 144
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
34-320 |
2.26e-18 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 83.04 E-value: 2.26e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 34 DAESIRAIHAAIDAGINLIDTAPMYeygKSEELVGRAIRDR---RDKVLIATKcgLWHRDARgsewftmgshtirrslrP 110
Cdd:cd19130 22 PADTQRAVATALEVGYRHIDTAAIY---GNEEGVGAAIAASgipRDELFVTTK--LWNDRHD-----------------G 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 111 DTIRIEVEESLRRLGVDRIDLYQTHWQAiePEKTPIADTMACLMDLRAQGKIRAIGVSNATTADMDAYRAAGELSACQPR 190
Cdd:cd19130 80 DEPAAAFAESLAKLGLDQVDLYLVHWPT--PAAGNYVHTWEAMIELRAAGRTRSIGVSNFLPPHLERIVAATGVVPAVNQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 191 YSMLDRAIEADVLPYCLRSNVAILAYSPLEQGLLTGkigmdrtfgaDESRNRIpwflpanrarvlamlggwkdlCAAHAC 270
Cdd:cd19130 158 IELHPAYQQRTIRDWAQAHDVKIEAWSPLGQGKLLG----------DPPVGAI---------------------AAAHGK 206
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1175985856 271 TLGQLVIAWTVaQPGLTIaLCGARKVAQVLENAKAGGLALDTATLARMRA 320
Cdd:cd19130 207 TPAQIVLRWHL-QKGHVV-FPKSVRRERMEDNLDVFDFDLTDTEIAAIDA 254
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
26-200 |
5.22e-18 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 82.71 E-value: 5.22e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 26 GPW-WGPTDDAESIRAI-HAAIDAGINLIDTAPMYEYGKSEELVGRAIRDRRDKVLIATKCGLwHRDARGSeWFTmgsht 103
Cdd:PRK10376 29 GPGvFGPPKDRDAAIAVlREAVALGVNHIDTSDFYGPHVTNQLIREALHPYPDDLTIVTKVGA-RRGEDGS-WLP----- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 104 irrSLRPDTIRIEVEESLRRLGVDRIDL--YQTHWQAIEPEKTPIADTMACLMDLRAQGKIRAIGVSNATTADMDAYRAA 181
Cdd:PRK10376 102 ---AFSPAELRRAVHDNLRNLGLDVLDVvnLRLMGDGHGPAEGSIEEPLTVLAELQRQGLVRHIGLSNVTPTQVAEARKI 178
|
170
....*....|....*....
gi 1175985856 182 GELSACQPRYSMLDRAIEA 200
Cdd:PRK10376 179 AEIVCVQNHYNLAHRADDA 197
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
23-169 |
1.20e-17 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 81.27 E-value: 1.20e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 23 IGGGPWwgPTDDAESIRAIHAAIDAGINLIDTAPMYeygKSEELVGRAIRDR---RDKVLIATKcgLWHRDargsewftm 99
Cdd:PRK11565 18 LGLGVW--QASNEEVITAIHKALEVGYRSIDTAAIY---KNEEGVGKALKEAsvaREELFITTK--LWNDD--------- 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 100 gshtirrSLRPDTiriEVEESLRRLGVDRIDLYQTHWQAiePEKTPIADTMACLMDLRAQGKIRAIGVSN 169
Cdd:PRK11565 82 -------HKRPRE---ALEESLKKLQLDYVDLYLMHWPV--PAIDHYVEAWKGMIELQKEGLIKSIGVCN 139
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
1-302 |
2.12e-17 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 81.57 E-value: 2.12e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 1 MHYRQIGTTDMKASCVAFGAWAIGGGPWWGPTddAESIRAIhaAIDAGINLIDTAPMYEYGKSEELVGRAIRD---RRDK 77
Cdd:cd19160 3 MKYRNLGKSGLRVSCLGLGTWVTFGSQISDET--AEDLLTV--AYEHGVNLFDTAEVYAAGKAERTLGNILKSkgwRRSS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 78 VLIATKCglwhrdargsewFTMGSHTIRRSLRPDTIRIEVEESLRRLGVDRIDLYQTHWQAIEPEKTPIADTMACLMDlr 157
Cdd:cd19160 79 YVVTTKI------------YWGGQAETERGLSRKHIIEGLRGSLDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVIN-- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 158 aQGKIRAIGVSNATTAD-MDAYRAAGELS----AC-QPRYSMLDR-AIEADVLPYCLRSNVAILAYSPLEQGLLTGKIGm 230
Cdd:cd19160 145 -QGMAMYWGTSRWSAMEiMEAYSVARQFNlippVCeQAEYHLFQReKVEMQLPELYHKIGVGSVTWSPLACGLITGKYD- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 231 DRTfgADESRNRIP---WFLPA--------NRARVLAMLggwkDLCAAHACTLGQLVIAWTVAQPGLTIALCGARKVAQV 299
Cdd:cd19160 223 GRV--PDTCRAAVKgyqWLKEKvqseegkkQQAKVKELH----PIADRLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQL 296
|
...
gi 1175985856 300 LEN 302
Cdd:cd19160 297 IEN 299
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
22-181 |
7.01e-17 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 78.99 E-value: 7.01e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWWGPTDDAesIRAIHAAIDAGINLIDTAPMYeygKSEELVGRAIR----DRRDkVLIATKcgLWHRDargsewf 97
Cdd:cd19127 11 ALGLGVFQTPPEET--ADAVATALADGYRLIDTAAAY---GNEREVGEGIRrsgvDRSD-IFVTTK--LWISD------- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 98 tMGSHTIRRSLrpdtirievEESLRRLGVDRIDLYQTHWqaiePEKTPIADTMAC---LMDLRAQGKIRAIGVSNATTAD 174
Cdd:cd19127 76 -YGYDKALRGF---------DASLRRLGLDYVDLYLLHW----PVPNDFDRTIQAykaLEKLLAEGRVRAIGVSNFTPEH 141
|
....*..
gi 1175985856 175 MDAYRAA 181
Cdd:cd19127 142 LERLIDA 148
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
22-281 |
7.78e-17 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 79.38 E-value: 7.78e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWWGPTDdaESIRAIHAAIDAGINLIDTAPMYEygkSEELVGRAIRD--------RRDKVLIATKcgLWHrdarg 93
Cdd:cd19118 9 AIGLGTWQAEPG--EVGAAVKIALKAGYRHLDLAKVYQ---NQHEVGQALKEllkeepgvKREDLFITSK--LWN----- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 94 sewftmGSHtirrslRPDTIRIEVEESLRRLGVDRIDLYQTHWQ-AIEPE--------------------KTPIADTMAC 152
Cdd:cd19118 77 ------NSH------RPEYVEPALDDTLKELGLDYLDLYLIHWPvAFKPTgdlnpltavptnggevdldlSVSLVDTWKA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 153 LMDLRAQGKIRAIGVSNATTADMDAY-RAAGELSACQpRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQglltgkigmd 231
Cdd:cd19118 145 MVELKKTGKVKSIGVSNFSIDHLQAIiEETGVVPAVN-QIEAHPLLLQDELVDYCKSKNIHITAYSPLGN---------- 213
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1175985856 232 rtfgadesrnripwflpaNRARVLAMLG--GWKDLCAAHACTLGQLVIAWTV 281
Cdd:cd19118 214 ------------------NLAGLPLLVQhpEVKAIAAKLGKTPAQVLIAWGI 247
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
23-168 |
1.39e-16 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 78.86 E-value: 1.39e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 23 IGGGPW-WGPTDDAESI---RAIHAAIDAGINLIDTAPmYeYGKSEELVGRA---IRDR--RDKVLIATKCGlwhrdaRG 93
Cdd:cd19164 18 FGAATFsYQYTTDPESIppvDIVRRALELGIRAFDTSP-Y-YGPSEIILGRAlkaLRDEfpRDTYFIITKVG------RY 89
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1175985856 94 SEW-FTMGSHTIRRSlrpdtirieVEESLRRLGVDRIDLYQTHwqaiEPEKTPIADTMAC---LMDLRAQGKIRAIGVS 168
Cdd:cd19164 90 GPDdFDYSPEWIRAS---------VERSLRRLHTDYLDLVYLH----DVEFVADEEVLEAlkeLFKLKDEGKIRNVGIS 155
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
22-316 |
1.40e-16 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 78.61 E-value: 1.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWwgPTDDAESIRAIHAAIDAGINLIDTAPMYEygkSEELVGRAIRD-------RRDKVLIATKcgLWHrdargs 94
Cdd:cd19123 14 ALGLGTW--KSKPGEVGQAVKQALEAGYRHIDCAAIYG---NEAEIGAALAEvfkegkvKREDLWITSK--LWN------ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 95 ewftmGSHtirrslRPDTIRIEVEESLRRLGVDRIDLYQTHWQ-AIEP--------------EKTPIADTMACLMDLRAQ 159
Cdd:cd19123 81 -----NSH------APEDVLPALEKTLADLQLDYLDLYLMHWPvALKKgvgfpesgedllslSPIPLEDTWRAMEELVDK 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 160 GKIRAIGVSNATTADMDAYRAagelsacQPRYSMLDRAIE-------ADVLPYCLRSNVAILAYSPLEQGlltgkigmdr 232
Cdd:cd19123 150 GLCRHIGVSNFSVKKLEDLLA-------TARIKPAVNQVElhpylqqPELLAFCRDNGIHLTAYSPLGSG---------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 233 tfgadesrNRIPWFLPANRARVLA--MLGGwkdLCAAHACTLGQLVIAWTVAQPGLTIALCGARK-VAQVLENAKAGGLA 309
Cdd:cd19123 213 --------DRPAAMKAEGEPVLLEdpVINK---IAEKHGASPAQVLIAWAIQRGTVVIPKSVNPErIQQNLEAAEVELDA 281
|
....*..
gi 1175985856 310 LDTATLA 316
Cdd:cd19123 282 SDMATIA 288
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
15-219 |
4.28e-16 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 77.18 E-value: 4.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 15 CVAFGAWAIgggpwwgptDDAESIRAIHAAIDAGINLIDTApmYEYGkSEELVGRAIRD-------RRDKVLIATKCglw 87
Cdd:cd19128 3 RLGFGTYKI---------TESESKEAVKNAIKAGYRHIDCA--YYYG-NEAFIGIAFSEifkdggvKREDLFITSKL--- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 88 hrdargseWFTMgshtirrsLRPDTIRIEVEESLRRLGVDRIDLYQTHW----------------QAIEPEKTPIADTMA 151
Cdd:cd19128 68 --------WPTM--------HQPENVKEQLLITLQDLQLEYLDLFLIHWplafdmdtdgdprddnQIQSLSKKPLEDTWR 131
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1175985856 152 CLMDLRAQGKIRAIGVSNATT---ADMDAYRAAGELS---ACQPrYSMLDRAIEadvlpYCLRSNVAILAYSPL 219
Cdd:cd19128 132 AMEQCVDEKLTKNIGVSNYSTkllTDLLNYCKIKPFMnqiECHP-YFQNDKLIK-----FCIENNIHVTAYRPL 199
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
22-219 |
7.64e-16 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 76.38 E-value: 7.64e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWWGPTDDAEsiRAIHAAIDAGINLIDTApmYEYGKSEElVGRAIRDR---RDKVLIATKC-GLWHRDARGSewf 97
Cdd:cd19117 16 AVGLGTWQSKPNEVA--KAVEAALKAGYRHIDTA--AIYGNEEE-VGQGIKDSgvpREEIFITTKLwCTWHRRVEEA--- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 98 tmgshtirrslrpdtirieVEESLRRLGVDRIDLYQTHW-------------------QAIEPEKTPIaDTMACLMDLRA 158
Cdd:cd19117 88 -------------------LDQSLKKLGLDYVDLYLMHWpvpldpdgndflfkkddgtKDHEPDWDFI-KTWELMQKLPA 147
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1175985856 159 QGKIRAIGVSNATTADMDAYRAAG-----------ELSACQPRYSMLDraieadvlpYCLRSNVAILAYSPL 219
Cdd:cd19117 148 TGKVKAIGVSNFSIKNLEKLLASPsakivpavnqiELHPLLPQPKLVD---------FCKSKGIHATAYSPL 210
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
22-219 |
8.28e-16 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 76.42 E-value: 8.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWWGptDDAESIRAIHAAIDAGINLIDTApmYEYGKSEElVGRAIRD------RRDKVLIATKCglwhrdargse 95
Cdd:cd19121 14 AVGLGTWQA--KAGEVKAAVAHALKIGYRHIDGA--LCYQNEDE-VGEGIKEaiaggvKREDLFVTTKL----------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 96 WFTMgsHTirrslrpdtiRIE--VEESLRRLGVDRIDLYQTHWQ-AIEPE----KTPI--------------ADTMACLM 154
Cdd:cd19121 78 WSTY--HR----------RVElcLDRSLKSLGLDYVDLYLVHWPvLLNPNgnhdLFPTlpdgsrdldwdwnhVDTWKQME 145
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1175985856 155 DLRAQGKIRAIGVSNATTADMDAYRAAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPL 219
Cdd:cd19121 146 KVLKTGKTKAIGVSNYSIPYLEELLKHATVVPAVNQVENHPYLPQQELVDFCKEKGILIEAYSPL 210
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
22-219 |
1.28e-14 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 72.76 E-value: 1.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWWGPTDDAESirAIHAAIDAGINLIDTAPMYEygkSEELVGRAIRD-------RRDKVLIATKcgLWHRDargs 94
Cdd:cd19125 13 AVGLGTWQADPGVVGN--AVKTAIKEGYRHIDCAAIYG---NEKEIGKALKKlfedgvvKREDLFITSK--LWCTD---- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 95 ewftmgshtirrsLRPDTIRIEVEESLRRLGVDRIDLYQTHW-----------QAIEPEKTPIADTMACLMDLRAQGKIR 163
Cdd:cd19125 82 -------------HAPEDVPPALEKTLKDLQLDYLDLYLIHWpvrlkkgahmpEPEEVLPPDIPSTWKAMEKLVDSGKVR 148
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1175985856 164 AIGVSNATTAD-MDAYRAAGELSA-----CQPRYSmldraiEADVLPYCLRSNVAILAYSPL 219
Cdd:cd19125 149 AIGVSNFSVKKlEDLLAVARVPPAvnqveCHPGWQ------QDKLHEFCKSKGIHLSAYSPL 204
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
22-219 |
1.75e-14 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 72.83 E-value: 1.75e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWWGptDDAESIRAIHAAIDAGINLIDTAPMYEygkSEELVGRAIRD-------RRDKVLIATKcgLW-HRDARG 93
Cdd:cd19154 14 LIGLGTWQS--KGAEGITAVRTALKAGYRLIDTAFLYQ---NEEAIGEALAElleegvvKREDLFITTK--LWtHEHAPE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 94 SewftmgshtIRRSLRpdtirieveESLRRLGVDRIDLYQTH--W--------------QAIEPEKTPIADTMACLMDLR 157
Cdd:cd19154 87 D---------VEEALR---------ESLKKLQLEYVDLYLIHapAafkddegesgtmenGMSIHDAVDVEDVWRGMEKVY 148
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1175985856 158 AQGKIRAIGVSNATTADMDAYRAAGELsacQPRYSMLDRAI---EADVLPYCLRSNVAILAYSPL 219
Cdd:cd19154 149 DEGLTKAIGVSNFNNDQIQRILDNARV---KPHNNQVECHLyfpQKELVEFCKKHNISVTSYATL 210
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
22-169 |
4.89e-14 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 71.15 E-value: 4.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWWGPTDDAESIRAIHAAIDAGINLIDTAPMYEygkSEELVGRAIRD--------RRDKVLIATKcgLWHRDARG 93
Cdd:cd19124 7 VIGMGTASDPPSPEDIKAAVLEAIEVGYRHFDTAAAYG---TEEALGEALAEalrlglvkSRDELFVTSK--LWCSDAHP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 94 sewftmgsHTIRRSLRpdtirieveESLRRLGVDRIDLYQTHWQA-IEPEK--TPIADTMACLMDLRA----------QG 160
Cdd:cd19124 82 --------DLVLPALK---------KSLRNLQLEYVDLYLIHWPVsLKPGKfsFPIEEEDFLPFDIKGvweameecqrLG 144
|
....*....
gi 1175985856 161 KIRAIGVSN 169
Cdd:cd19124 145 LTKAIGVSN 153
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
22-219 |
7.30e-14 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 70.60 E-value: 7.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWWGPTDdaESIRAIHAAIDAGINLIDTAPMYeygKSEELVGRAIRD-------RRDKVLIATKcgLWhrdargs 94
Cdd:cd19111 6 VIGLGTYQSPPE--EVRAAVDYALFVGYRHIDTALSY---QNEKAIGEALKWwlkngklKREEVFITTK--LP------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 95 ewfTMGshtirrsLRPDTIRIEVEESLRRLGVDRIDLYQTHWQA----------IEPEKTPIADTMACLMDLRAQGKIRA 164
Cdd:cd19111 72 ---PVY-------LEFKDTEKSLEKSLENLKLPYVDLYLIHHPCgfvnkkdkgeRELASSDVTSVWRAMEALVSEGKVKS 141
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1175985856 165 IGVSNATTADMDAYRAageLSACQPRYSMLDRAI---EADVLPYCLRSNVAILAYSPL 219
Cdd:cd19111 142 IGLSNFNPRQINKILA---YAKVKPSNLQLECHAylqQRELRKFCNKKNIVVTAYAPL 196
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
38-320 |
5.89e-13 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 67.74 E-value: 5.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 38 IRAIHAAIDAGINLIDTAPMYEygkSEELVGRAIRD---RRDKVLIATKcgLWHRDargsewftmgshtirrsLRPDTIR 114
Cdd:PRK11172 19 IDSVKTALELGYRAIDTAQIYD---NEAAVGQAIAEsgvPRDELFITTK--IWIDN-----------------LAKDKLI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 115 IEVEESLRRLGVDRIDLYQTHWQAIEPEkTPIADTMACLMDLRAQGKIRAIGVSNATTADMD---AYRAAGELSACQPRY 191
Cdd:PRK11172 77 PSLKESLQKLRTDYVDLTLIHWPSPNDE-VSVEEFMQALLEAKKQGLTREIGISNFTIALMKqaiAAVGAENIATNQIEL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 192 S--MLDRAIEAdvlpYCLRSNVAILAYSPLEQGLLTGkigmdrtfgaDEsrnripwflpanrarVLAmlggwkDLCAAHA 269
Cdd:PRK11172 156 SpyLQNRKVVA----FAKEHGIHVTSYMTLAYGKVLK----------DP---------------VIA------RIAAKHN 200
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1175985856 270 CTLGQLVIAWTVAQ-----PGLTialcgarKVAQVLENAKAGGLALDTATLARMRA 320
Cdd:PRK11172 201 ATPAQVILAWAMQLgysviPSST-------KRENLASNLLAQDLQLDAEDMAAIAA 249
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
33-223 |
5.76e-12 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 65.17 E-value: 5.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 33 DDAESIRAIHAAIDAGINLIDTAPMYeygKSEELVGRAIRD-------RRDKVLIATKcgLWHRDargsewftmgsHtir 105
Cdd:cd19129 17 DPSATRNAVKAALEAGFRHFDCAERY---RNEAEVGEAMQEvfkagkiRREDLFVTTK--LWNTN-----------H--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 106 rslRPDTIRIEVEESLRRLGVDRIDLYQTHWQ-AIEP--EKTP--------------IADTMACLMDLRAQGKIRAIGVS 168
Cdd:cd19129 78 ---RPERVKPAFEASLKRLQLDYLDLYLIHTPfAFQPgdEQDPrdangnviyddgvtLLDTWRAMERLVDEGRCKAIGLS 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1175985856 169 NATTADMDAYRAAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPLEQGL 223
Cdd:cd19129 155 DVSLEKLREIFEAARIKPAVVQVESHPYLPEWELLDFCKNHGIVLQAFAPLGHGM 209
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
36-169 |
6.84e-12 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 64.94 E-value: 6.84e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 36 ESIRAIHAAIDAGINLIDTAPMYEygkSEELVGRAIRD-------RRDKVLIATKCglwhrdargseWFTmgshtirrSL 108
Cdd:cd19108 28 KALEATKLAIDAGFRHIDSAYLYQ---NEEEVGQAIRSkiadgtvKREDIFYTSKL-----------WCT--------FH 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 109 RPDTIRIEVEESLRRLGVDRIDLYQTHWQ-AIEPEKTP---------IADTmaclMDLRA----------QGKIRAIGVS 168
Cdd:cd19108 86 RPELVRPALEKSLKKLQLDYVDLYLIHFPvALKPGEELfpkdengklIFDT----VDLCAtweamekckdAGLAKSIGVS 161
|
.
gi 1175985856 169 N 169
Cdd:cd19108 162 N 162
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
14-219 |
1.34e-10 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 61.39 E-value: 1.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 14 SCVAF--GAW--AIGGGPWWGPTDDAESirAIHAAIDAGINLIDTAPMYeygKSEELVGRAIRD-------RRDKVLIAT 82
Cdd:cd19155 2 NCVTFnnGEKmpVVGLGTWQSSPEEIET--AVDTALEAGYRHIDTAYVY---RNEAAIGNVLKKwidsgkvKREELFIVT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 83 KcglwhrdargsewFTMGSHtirrslRPDTIRIEVEESLRRLGVDRIDLYQTH-------------WQAIEPE-----KT 144
Cdd:cd19155 77 K-------------LPPGGN------RREKVEKFLLKSLEKLQLDYVDLYLIHfpvgslskeddsgKLDPTGEhkqdyTT 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 145 PIADTMACLMDLRAQGKIRAIGVSNATTADMdayraAGELSACQPRYSMLDRAIEA-----DVLPYCLRSNVAILAYSPL 219
Cdd:cd19155 138 DLLDIWKAMEAQVDQGLTRSIGLSNFNREQM-----ARILKNARIKPANLQVELHVylqqkDLVDFCSTHSITVTAYAPL 212
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
23-219 |
1.62e-10 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 61.25 E-value: 1.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 23 IGGGPWWGPTDDAESirAIHAAIDAGINLIDTAPMYEygkSEELVGRAIRD--------RRDKVLIATKcgLWHRdargs 94
Cdd:cd19106 10 IGLGTWKSKPGQVKA--AVKYALDAGYRHIDCAAVYG---NEQEVGEALKEkvgpgkavPREDLFVTSK--LWNT----- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 95 ewftmgSHtirrslRPDTIRIEVEESLRRLGVDRIDLYQTHWQ----------------AIEPEKTPIADTMACLMDLRA 158
Cdd:cd19106 78 ------KH------HPEDVEPALRKTLKDLQLDYLDLYLIHWPyafergdnpfpknpdgTIRYDSTHYKETWKAMEKLVD 145
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1175985856 159 QGKIRAIGVSNATTADMDAYRAAGELSA------CQPRYSmldraiEADVLPYCLRSNVAILAYSPL 219
Cdd:cd19106 146 KGLVKAIGLSNFNSRQIDDILSVARIKPavlqveCHPYLA------QNELIAHCKARGLVVTAYSPL 206
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
8-279 |
2.70e-10 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 60.33 E-value: 2.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 8 TTDMKASCVAFGAWAIGGGpwwgptdDAESIRAIHAAIDAGINLIDTAPMYEygkSEELVGRAIRD--------RRDKVL 79
Cdd:cd19122 4 NNGVKIPAVGFGTFANEGA-------KGETYAAVTKALDVGYRHLDCAWFYL---NEDEVGDAVRDflkenpsvKREDLF 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 80 IATKcgLWHRdargsewftmgSHtirrslRPDTIRIEVEESLRRLGVDRIDLYQTHWqAIEPEK----TPIAD------- 148
Cdd:cd19122 74 ICTK--VWNH-----------LH------EPEDVKWSIDNSLKNLKLDYIDLFLVHW-PIAAEKndqrSPKLGpdgkyvi 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 149 ----------TMACLMDLRAQGKIRAIGVSNATTADMDAYRAAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSP 218
Cdd:cd19122 134 lkdltenpepTWRAMEEIYESGKAKAIGVSNWTIPGLKKLLSFAKVKPHVNQIEIHPFLPNEELVDYCFSNDILPEAYSP 213
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1175985856 219 LeqglltgkigmdrtfgadESRNRIPwfLPANRARVLAMLggwKDLCAAHACTLGQLVIAW 279
Cdd:cd19122 214 L------------------GSQNQVP--STGERVSENPTL---NEVAEKGGYSLAQVLIAW 251
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
22-219 |
3.68e-10 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 59.82 E-value: 3.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWwGPTDDAESIR-AIHAAIDAGINLIDTAPMYEygkSEELVGRAIRD-------RRDKVLIATKCglwhrdarg 93
Cdd:cd19119 14 ALGLGTA-SPHEDRAEVKeAVEAAIKEGYRHIDTAYAYE---TEDFVGEAIKRaiddgsiKREELFITTKV--------- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 94 seWFTMGSHtIRRSLrpdtirievEESLRRLGVDRIDLYQTHW------------QAIEPE----KTPIA------DTMA 151
Cdd:cd19119 81 --WPTFYDE-VERSL---------DESLKALGLDYVDLLLVHWpvcfekdsddsgKPFTPVnddgKTRYAasgdhiTTYK 148
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1175985856 152 CLMDLRAQGKIRAIGVSNATTADMDAYRAAGELSACQPRYSMLDRAIEADVLPYCLRSNVAILAYSPL 219
Cdd:cd19119 149 QLEKIYLDGRAKAIGVSNYSIVYLERLIKECKVVPAVNQVELHPHLPQMDLRDFCFKHGILVTAYSPL 216
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
23-219 |
1.05e-09 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 58.58 E-value: 1.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 23 IGGGPWWGPTDDAESirAIHAAIDAGINLIDTAPMYEygkSEELVGRAIRD-------RRDKVLIATKcgLWhrdargSE 95
Cdd:cd19107 7 LGLGTWKSPPGQVTE--AVKVAIDAGYRHIDCAYVYQ---NENEVGEAIQEkikeqvvKREDLFIVSK--LW------CT 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 96 WFtmgshtiRRSLrpdtIRIEVEESLRRLGVDRIDLYQTHW----QA------------IEPEKTPIADTMACLMDLRAQ 159
Cdd:cd19107 74 FH-------EKGL----VKGACQKTLSDLKLDYLDLYLIHWptgfKPgkelfpldesgnVIPSDTTFLDTWEAMEELVDE 142
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1175985856 160 GKIRAIGVSNATTADMDA--------YRAAGELSACQPrYSMLDRAIEadvlpYCLRSNVAILAYSPL 219
Cdd:cd19107 143 GLVKAIGVSNFNHLQIERilnkpglkYKPAVNQIECHP-YLTQEKLIQ-----YCQSKGIVVTAYSPL 204
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
16-217 |
1.69e-09 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 58.23 E-value: 1.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 16 VAFGAWAIgggpwwgptDDAESIRAIHAAIDAGINLIDTAPmyEYGKSEEL---VGRAIRD---RRDKVLIATKcgLWHr 89
Cdd:cd19113 14 VGFGCWKL---------DNATAADQIYQAIKAGYRLFDGAE--DYGNEKEVgegVNRAIDEglvKREELFLTSK--LWN- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 90 dargsewftmGSHtirrslRPDTIRIEVEESLRRLGVDRIDLYQTHW----------------------QAIEPEKTPIA 147
Cdd:cd19113 80 ----------NFH------DPKNVETALNKTLSDLKLDYVDLFLIHFpiafkfvpieekyppgfycgdgDNFVYEDVPIL 143
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1175985856 148 DTMACLMDLRAQGKIRAIGVSNATTADM-DAYRAA----GELSACQPRYSMLDRAIEadvlpYCLRSNVAILAYS 217
Cdd:cd19113 144 DTWKALEKLVDAGKIKSIGVSNFPGALIlDLLRGAtikpAVLQIEHHPYLQQPKLIE-----YAQKAGITITAYS 213
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
16-217 |
2.16e-09 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 57.82 E-value: 2.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 16 VAFGAWAIgggpwwgptDDAESIRAIHAAIDAGINLIDTApmYEYGKSEEL---VGRAIRD---RRDKVLIATKcgLWHR 89
Cdd:cd19115 16 VGFGLWKV---------NNDTCADQVYNAIKAGYRLFDGA--CDYGNEVEAgqgVARAIKEgivKREDLFIVSK--LWNT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 90 dargsewFTMGSHtirrslrpdtirieVEESLRR----LGVDRIDLYQTH-----------------WQA----IEPEKT 144
Cdd:cd19115 83 -------FHDGER--------------VEPICRKqladWGIDYFDLFLIHfpialkyvdpavryppgWFYdgkkVEFSNA 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 145 PIADTMACLMDLRAQGKIRAIGVSN-ATTADMDAYRAAgelsacQPRYSMLDraIE-------ADVLPYCLRSNVAILAY 216
Cdd:cd19115 142 PIQETWTAMEKLVDKGLARSIGVSNfSAQLLMDLLRYA------RIRPATLQ--IEhhpyltqPRLVKYAQKEGIAVTAY 213
|
.
gi 1175985856 217 S 217
Cdd:cd19115 214 S 214
|
|
| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
43-319 |
2.21e-09 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 57.74 E-value: 2.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 43 AAIDAGINLIDTApmYEYGKSEELVGRAIRDR---RDKVLIATKCGL-----WHRDARGSEwftMGSHTIRRSLRpdtir 114
Cdd:cd19098 43 AAWAAGVRYFDAA--RSYGRAEEFLGSWLRSRniaPDAVFVGSKWGYtytadWQVDAAVHE---VKDHSLARLLK----- 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 115 iEVEESLRRLGvDRIDLYQTHWQAIEPEKTPIADTMACLMDLRAQGkiRAIGVSNATTADMDAYRAAGEL--------SA 186
Cdd:cd19098 113 -QWEETRSLLG-KHLDLYQIHSATLESGVLEDADVLAALAELKAEG--VKIGLSLSGPQQAETLRRALEIeidgarlfDS 188
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170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 187 CQPRYSMLD-RAIEAdvLPYCLRSNVAILAYSPLEQGLLTgkigmdrtfgadeSRNRIPWFLPAnrarvlamLGGWKDLC 265
Cdd:cd19098 189 VQATWNLLEqSAGEA--LEEAHEAGMGVIVKEALANGRLT-------------DRNPSPELAPL--------MAVLKAVA 245
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250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1175985856 266 AAHACTLGQLVIAWTVAQPGLTIALCGARKVAQVLENAKAGGLALDTATLARMR 319
Cdd:cd19098 246 DRLGVTPDALALAAVLAQPFVDVVLSGAATPEQLRSNLRALDVSLDLELLAALA 299
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| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
22-219 |
2.27e-09 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 57.66 E-value: 2.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWwgPTDDAESIRAIHAAIDAGINLIDTAPMYEygkSEELVGRAIRD-------RRDKVLIATKCglwhrdargs 94
Cdd:cd19110 6 AVGLGTW--KASPGEVTEAVKVAIDAGYRHFDCAYLYH---NESEVGAGIREkikegvvRREDLFIVSKL---------- 70
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 95 eWFTmgSHtiRRSLrpdtIRIEVEESLRRLGVDRIDLYQTHW----------------QAIEPEKTPIADTMACLMDLRA 158
Cdd:cd19110 71 -WCT--CH--KKSL----VKTACTRSLKALKLNYLDLYLIHWpmgfkpgepdlpldrsGMVIPSDTDFLDTWEAMEDLVI 141
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170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1175985856 159 QGKIRAIGVSNATTADMD--------AYRAAGELSACQPRYSmldraiEADVLPYCLRSNVAILAYSPL 219
Cdd:cd19110 142 EGLVKNIGVSNFNHEQLErllnkpglRVKPVTNQIECHPYLT------QKKLISFCQSRNVSVTAYRPL 204
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|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
12-169 |
5.27e-09 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 56.41 E-value: 5.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 12 KASCVAFGAWAIgggpwwgPTDDAEsiRAIHAAIDAGINLIDTAPMYeygKSEELVGRAIRD-------RRDKVLIATKc 84
Cdd:cd19114 3 KMPLVGFGTAKI-------KANETE--EVIYNAIKVGYRLIDGALLY---GNEAEVGRGIRKaiqeglvKREDLFIVTK- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 85 gLWHrdargsewftmGSHtirrslRPDTIRIEVEESLRRLGVDRIDLYQTHW----QAIEP------------------E 142
Cdd:cd19114 70 -LWN-----------NFH------GKDHVREAFDRQLKDYGLDYIDLYLIHFpipaAYVDPaenypflwkdkelkkfplE 131
|
170 180
....*....|....*....|....*..
gi 1175985856 143 KTPIADTMACLMDLRAQGKIRAIGVSN 169
Cdd:cd19114 132 QSPMQECWREMEKLVDAGLVRNIGIAN 158
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|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
22-219 |
1.08e-04 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 43.24 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 22 AIGGGPWwgpTDDAESIR-AIHAAIDAGINLIDTAPMYeygKSEELVGRAIRD-------RRDKVLIATKcgLWHRDarg 93
Cdd:cd19112 13 VIGLGVW---RMEPGEIKeLILNAIKIGYRHFDCAADY---KNEKEVGEALAEafktglvKREDLFITTK--LWNSD--- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175985856 94 sewftmgsHTIrrslrpdtIRIEVEESLRRLGVDRIDLYQTHW-------------QAIEPEK-------TPIADTMACL 153
Cdd:cd19112 82 --------HGH--------VIEACKDSLKKLQLDYLDLYLVHFpvatkhtgvgttgSALGEDGvldidvtISLETTWHAM 145
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1175985856 154 MDLRAQGKIRAIGVSNAT---TADMDAYraagelSACQPRYSMldraIEA-------DVLPYCLRSNVAILAYSPL 219
Cdd:cd19112 146 EKLVSAGLVRSIGISNYDiflTRDCLAY------SKIKPAVNQ----IEThpyfqrdSLVKFCQKHGISVTAHTPL 211
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