NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1179764616|gb|ORI96852|]
View 

homoserine kinase [Leuconostoc mesenteroides subsp. mesenteroides]

Protein Classification

homoserine kinase( domain architecture ID 11479451)

homoserine kinase catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate

CATH:  3.30.230.10|3.30.70.890
EC:  2.7.1.39
Gene Ontology:  GO:0016310|GO:0009088|GO:0004413|GO:0005737|GO:0005524
PubMed:  11188689|11535056
SCOP:  4001303|4000959

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK01212 PRK01212
homoserine kinase; Provisional
 1-289 5.61e-110

homoserine kinase; Provisional


:

Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 320.56  E-value: 5.61e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616   1 MIKITIPATSANIGPGFDSLGVALKLYLTLEVYEETS-----EWQVIHDYGANMPSDV-NNFIVKTALLLAPNL---TPH 71
Cdd:PRK01212    3 MVKVRVPATSANLGPGFDSLGLALSLYDEVLVGDVVSveaefSIEVIGEGADKLPLDPeKNLVYQAALKFLEKLgkpPGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616  72 RIVVKSDIPLARGLGSSSSALLAGLAMANVLADMRLSNDSLLEQATALEGHPDNVAPALLGGSVAAfFDGEQVYHAPLSL 151
Cdd:PRK01212   83 RIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEGHPDNVAPALLGGLVLA-LEENGVISVKIPV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616 152 PKDINFITFIPNYELLTTEARNALPAKMTFKDSVAASAISNTLTAALNAGDFNTARVLIeKDQFHEQARAHLAPHLKIIR 231
Cdd:PRK01212  162 FDDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAM-KDVLHEPYRAKLIPGFAEVR 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1179764616 232 DTAHQLEIIGTYLSGAGPTVITLVSKDNATKLLKALTN---MALPGKLLLLEPDYTGLQIT 289
Cdd:PRK01212  241 QAALEAGALGAGISGAGPTVFALCDKEDAEKVADALQKaflQGIEGFVHVLRLDTAGARVL 301
 
Name Accession Description Interval E-value
PRK01212 PRK01212
homoserine kinase; Provisional
 1-289 5.61e-110

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 320.56  E-value: 5.61e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616   1 MIKITIPATSANIGPGFDSLGVALKLYLTLEVYEETS-----EWQVIHDYGANMPSDV-NNFIVKTALLLAPNL---TPH 71
Cdd:PRK01212    3 MVKVRVPATSANLGPGFDSLGLALSLYDEVLVGDVVSveaefSIEVIGEGADKLPLDPeKNLVYQAALKFLEKLgkpPGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616  72 RIVVKSDIPLARGLGSSSSALLAGLAMANVLADMRLSNDSLLEQATALEGHPDNVAPALLGGSVAAfFDGEQVYHAPLSL 151
Cdd:PRK01212   83 RIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEGHPDNVAPALLGGLVLA-LEENGVISVKIPV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616 152 PKDINFITFIPNYELLTTEARNALPAKMTFKDSVAASAISNTLTAALNAGDFNTARVLIeKDQFHEQARAHLAPHLKIIR 231
Cdd:PRK01212  162 FDDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAM-KDVLHEPYRAKLIPGFAEVR 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1179764616 232 DTAHQLEIIGTYLSGAGPTVITLVSKDNATKLLKALTN---MALPGKLLLLEPDYTGLQIT 289
Cdd:PRK01212  241 QAALEAGALGAGISGAGPTVFALCDKEDAEKVADALQKaflQGIEGFVHVLRLDTAGARVL 301
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 1-290 9.59e-103

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 302.02  E-value: 9.59e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616   1 MIKITIPATSANIGPGFDSLGVALKLYLTLEVYE-ETSEWQVIH--DYGANMPSDVNNFIVKTALLLA----PNLTPHRI 73
Cdd:COG0083     2 SVKVRVPATSANLGPGFDSLGLALSLYDEVEVERsDEPGLEIEIegEGADELPTDEDNLVYQAALALLeklgKEPPGLRI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616  74 VVKSDIPLARGLGSSSSALLAGLAMANVLADMRLSNDSLLEQATALEGHPDNVAPALLGGSVAAFFDGEQVYHAPLSLPK 153
Cdd:COG0083    82 EIEKGIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEGEGHPDNVAPALLGGLVLSRSDGEPVRVVRLPVPP 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616 154 DINFITFIPNYELLTTEARNALPAKMTFKDSVAASAISNTLTAALNAGDFNTARVLIEkDQFHEQARAHLAPHLKIIRDT 233
Cdd:COG0083   162 DLKAVVVIPDFELSTKEARAVLPKQVPLKDAVFNSSRAALLVAALATGDYELLGRAME-DRLHEPYRAKLIPGFDEVKEA 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1179764616 234 AHQLEIIGTYLSGAGPTVITLVSKDNATKLLKALTN----MALPGKLLLLEPDYTGLQITK 290
Cdd:COG0083   241 ALEAGALGAGISGAGPTVLALADDEEAEAVAEAMKAafaeAGIDARVYVLKIDNEGARVLE 301
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 2-289 5.81e-60

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 193.00  E-value: 5.81e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616   2 IKITIPATSANIGPGFDSLGVALKLYLTLEVYEET------SEWQVIHDYGANMPSDV-NNFIVKTALLLAPNL----TP 70
Cdd:TIGR00191   1 FRVKVPASSANLGPGFDVLGAALSLYLGLTVTDVVaqesddTEIEAEGEGVEKIPTEPtDNLIYQVAKRFLDQLgirmPP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616  71 HRIVVKSDIPLARGLGSSSSALLAGLAMANVLADMRLSNDSLLEQATALEGHPDNVAPALLGGSVAAFFDGEQVYHAPLS 150
Cdd:TIGR00191  81 VKVTLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLSKERLLDYASELEGHPDNVAPALLGGFQLAFVEDDKLEVLKIP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616 151 LPKDINFITFIPNYELLTTEARNALPAKMTFKDSVAASAISNTLTAALNAGDFNTARVLIeKDQFHEQARAHLAPHLKII 230
Cdd:TIGR00191 161 IFSKLDWVLAIPNIEVSTAEARAVLPKAYPRQDLVFNLSHLAGLVHAIYQKKPDLGAIMM-KDRIHQPYRESLIPNLFKI 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1179764616 231 RDTAHQLEIIGTYLSGAGPTVITLVSK-DNATKLLKALTNMALPGKLL---LLEPDYTGLQIT 289
Cdd:TIGR00191 240 KQAALEKGAYGITISGSGPTILAMADEeFAEQKEQDLLEVLHKQGIEGtvhVLDFDNDGARVE 302
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 72-133 6.00e-11

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 57.17  E-value: 6.00e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1179764616  72 RIVVKSDIPLARGLGSSSSALLAGLAMANVLADMRLSNDSLL--EQATALEGHPDNVAPALLGG 133
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGLPLAKLALEaeELAGGGRGGGMDVAASLYGG 64
 
Name Accession Description Interval E-value
PRK01212 PRK01212
homoserine kinase; Provisional
 1-289 5.61e-110

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 320.56  E-value: 5.61e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616   1 MIKITIPATSANIGPGFDSLGVALKLYLTLEVYEETS-----EWQVIHDYGANMPSDV-NNFIVKTALLLAPNL---TPH 71
Cdd:PRK01212    3 MVKVRVPATSANLGPGFDSLGLALSLYDEVLVGDVVSveaefSIEVIGEGADKLPLDPeKNLVYQAALKFLEKLgkpPGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616  72 RIVVKSDIPLARGLGSSSSALLAGLAMANVLADMRLSNDSLLEQATALEGHPDNVAPALLGGSVAAfFDGEQVYHAPLSL 151
Cdd:PRK01212   83 RIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEGHPDNVAPALLGGLVLA-LEENGVISVKIPV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616 152 PKDINFITFIPNYELLTTEARNALPAKMTFKDSVAASAISNTLTAALNAGDFNTARVLIeKDQFHEQARAHLAPHLKIIR 231
Cdd:PRK01212  162 FDDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAM-KDVLHEPYRAKLIPGFAEVR 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1179764616 232 DTAHQLEIIGTYLSGAGPTVITLVSKDNATKLLKALTN---MALPGKLLLLEPDYTGLQIT 289
Cdd:PRK01212  241 QAALEAGALGAGISGAGPTVFALCDKEDAEKVADALQKaflQGIEGFVHVLRLDTAGARVL 301
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 1-290 9.59e-103

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 302.02  E-value: 9.59e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616   1 MIKITIPATSANIGPGFDSLGVALKLYLTLEVYE-ETSEWQVIH--DYGANMPSDVNNFIVKTALLLA----PNLTPHRI 73
Cdd:COG0083     2 SVKVRVPATSANLGPGFDSLGLALSLYDEVEVERsDEPGLEIEIegEGADELPTDEDNLVYQAALALLeklgKEPPGLRI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616  74 VVKSDIPLARGLGSSSSALLAGLAMANVLADMRLSNDSLLEQATALEGHPDNVAPALLGGSVAAFFDGEQVYHAPLSLPK 153
Cdd:COG0083    82 EIEKGIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEGEGHPDNVAPALLGGLVLSRSDGEPVRVVRLPVPP 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616 154 DINFITFIPNYELLTTEARNALPAKMTFKDSVAASAISNTLTAALNAGDFNTARVLIEkDQFHEQARAHLAPHLKIIRDT 233
Cdd:COG0083   162 DLKAVVVIPDFELSTKEARAVLPKQVPLKDAVFNSSRAALLVAALATGDYELLGRAME-DRLHEPYRAKLIPGFDEVKEA 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1179764616 234 AHQLEIIGTYLSGAGPTVITLVSKDNATKLLKALTN----MALPGKLLLLEPDYTGLQITK 290
Cdd:COG0083   241 ALEAGALGAGISGAGPTVLALADDEEAEAVAEAMKAafaeAGIDARVYVLKIDNEGARVLE 301
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 2-289 5.81e-60

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 193.00  E-value: 5.81e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616   2 IKITIPATSANIGPGFDSLGVALKLYLTLEVYEET------SEWQVIHDYGANMPSDV-NNFIVKTALLLAPNL----TP 70
Cdd:TIGR00191   1 FRVKVPASSANLGPGFDVLGAALSLYLGLTVTDVVaqesddTEIEAEGEGVEKIPTEPtDNLIYQVAKRFLDQLgirmPP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616  71 HRIVVKSDIPLARGLGSSSSALLAGLAMANVLADMRLSNDSLLEQATALEGHPDNVAPALLGGSVAAFFDGEQVYHAPLS 150
Cdd:TIGR00191  81 VKVTLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLSKERLLDYASELEGHPDNVAPALLGGFQLAFVEDDKLEVLKIP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616 151 LPKDINFITFIPNYELLTTEARNALPAKMTFKDSVAASAISNTLTAALNAGDFNTARVLIeKDQFHEQARAHLAPHLKII 230
Cdd:TIGR00191 161 IFSKLDWVLAIPNIEVSTAEARAVLPKAYPRQDLVFNLSHLAGLVHAIYQKKPDLGAIMM-KDRIHQPYRESLIPNLFKI 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1179764616 231 RDTAHQLEIIGTYLSGAGPTVITLVSK-DNATKLLKALTNMALPGKLL---LLEPDYTGLQIT 289
Cdd:TIGR00191 240 KQAALEKGAYGITISGSGPTILAMADEeFAEQKEQDLLEVLHKQGIEGtvhVLDFDNDGARVE 302
PTZ00299 PTZ00299
homoserine kinase; Provisional
 2-255 2.13e-34

homoserine kinase; Provisional


Pssm-ID: 140320  Cd Length: 336  Bit Score: 127.31  E-value: 2.13e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616   2 IKITIPATSANIGPGFDSLGVALKLYLTLEV-YEETSEWQVIHDYGANMPSDVNNFIVKTALLL-----APNLTPHRIVV 75
Cdd:PTZ00299    8 VVLRVPATTANIGPAYDTLGMALSIFMELTVeHADAFSMTVEGEGSEHISTDEDNMVVQACRLAfeeyaHKSMPPLKFIM 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616  76 KSDIPLARGLGSSSSALLAGLAMANVLADMRL---SNDSLLEQATALEGHPDNVAPALLGGSVAAFFDGEQ---VYHAPl 149
Cdd:PTZ00299   88 HSNIPYGCGCGSSSAAAVAGFVAGMKLCGLTMeteNEEALLQAIAKFEGHPDNAAPAIYGGIQLVYKKDNGrflTYRVP- 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616 150 sLPKDINFITFIPN--YELLTTEARNALPAKMTFKDSVAASAISNTLTAALNAGDFNTARVLieKDQFHEQARAH-LAPH 226
Cdd:PTZ00299  167 -TPPNLSVVLFVPHnkMKANTHVTRNLIPTSVSLEDAVFNISRTSILVLALSTGDLRMLKSC--SDKLHEQQRSDaLFPH 243

                         250       260
                  ....*....|....*....|....*....
gi 1179764616 227 LKIIRDTAHQLEIIGTYLSGAGPTVITLV 255
Cdd:PTZ00299  244 FRPCVKAAREAGAHYAFLSGAGPSVCALV 272
PLN02451 PLN02451
homoserine kinase
 7-255 1.50e-23

homoserine kinase


Pssm-ID: 215248  Cd Length: 370  Bit Score: 98.71  E-value: 1.50e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616   7 PATSANIGPGFDSLGVA---LKLYLTLEVYEETSEWQV----IHDYGANMPSD-VNNF--IVKTALLLAPNLTPH--RIV 74
Cdd:PLN02451   59 PATVANLGPGFDFLGCAvdgLGDFVTARVDPGVRPGEVsiseITGDTGRLSKDpLRNCagIAAIATMKLLGIRSVglSLS 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616  75 VKSDIPLARGLGSSSSALLAGLAMANVLADMRLSNDSL----LEQATALEG-HPDNVAPALLGGSVAaFFDGEQVYHAPL 149
Cdd:PLN02451  139 LHKGLPLGSGLGSSAASAAAAAVAVNELFGSPLGKDDLvlagLESEAKVSGyHADNIAPALMGGFVL-IRSYEPLHLIPL 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616 150 SLP--KDINFITFIPNYELLTTEARNALPAKMTFKDSVAASAISNTLTAALNAGDFNTARVLIEKDQFHEQARAHLAPHL 227
Cdd:PLN02451  218 RFPsaKDLFFVLVSPDFEAPTKKMRAALPKEIPMKHHVWNCSQAAALVAAILQGDAVLLGEALSSDKIVEPTRAPLIPGM 297

                         250       260
                  ....*....|....*....|....*...
gi 1179764616 228 KIIRDTAHQLEIIGTYLSGAGPTVITLV 255
Cdd:PLN02451  298 EAVKKAALEAGAYGCTISGAGPTAVAVI 325
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 72-133 6.00e-11

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 57.17  E-value: 6.00e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1179764616  72 RIVVKSDIPLARGLGSSSSALLAGLAMANVLADMRLSNDSLL--EQATALEGHPDNVAPALLGG 133
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGLPLAKLALEaeELAGGGRGGGMDVAASLYGG 64
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 19-248 6.71e-06

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 46.37  E-value: 6.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616  19 SLGVALKLYLTLEVYE--------ETSEWQVIHDYGANMPSDVNNF---IVKTALLLAPNLTPHRIVVKSDIPLARGLGS 87
Cdd:COG1577    19 AIAVAVDRRATVTVEPsdddklriESPDLGGTLDLDPLADAALRYIkaaIEAALEYLGLPLKGFDIEIDSEIPRKRGLGS 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616  88 SSSALLAGLAMANVLADMRLSNDSLLE--QATALEGHP-----DNVApALLGGSVaAFFDGEQVyhAPLSLPKDINFI-- 158
Cdd:COG1577    99 SAAVAVAVIRALAAFYGVELSKEELFKlaLEAEKIVHGnpsglDTAA-STYGGPI-YYQRGDRA--EPLELPKNLPLVvg 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616 159 -TFIPnyeLLTTEA---------RNALPAKMTFKDSvaaSAISNTLTAALNAGDFNTARVLIekdqfhEQARAHLA---- 224
Cdd:COG1577   175 dTGVP---ASTKELvakvrklkeRNPELYEAFLEEI---GDLVEEAIEALEEGDLEALGELM------NENHGLLRalgv 242

                         250       260
                  ....*....|....*....|....*.
gi 1179764616 225 --PHLKIIRDTAHQLEIIGTYLSGAG 248
Cdd:COG1577   243 stPELDRLVEAARKAGALGAKLTGAG 268
PduX COG4542
PduX protein involved in propanediol utilization and related proteins [Secondary metabolites ...
 72-120 1.15e-04

PduX protein involved in propanediol utilization and related proteins [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443608 [Multi-domain]  Cd Length: 286  Bit Score: 42.92  E-value: 1.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1179764616  72 RIVVKSDIPLARGLGSSSSALLAGLAMANVLADMRLSNDSLLEQATALE 120
Cdd:COG4542    72 RIELRSDIPVGKGMASSTADIAATARAVARALGKELSPEELARLAVAIE 120
PRK03817 PRK03817
galactokinase; Provisional
 70-269 1.27e-04

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 43.06  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616  70 PHRIVVKSDIPLARGLGSSSSALLAGLAMANVLADMRLSNDSLLEQATALE--------GHPDNVAPALLGGSVAAFFDG 141
Cdd:PRK03817   86 GVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAEnefvgvpcGIMDQFAVAFGKKDHAIFLDT 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616 142 EQVYHAPLSLPKDINFITFIPN--YELLTTE-------ARNALPA--KMTFKDsVAASAISN------------------ 192
Cdd:PRK03817  166 MTLEYEYVPFPEDYEILVFDTGvkRELASSEynerrqeCEEALKIlgKKSSKE-VTEEDLSKlppllrkragyvlrener 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616 193 --TLTAALNAGDFNT-ARVLIEKdqfHEQARAHL---APHLKIIRDTAHQLEIIGTYLSGA--GPTVITLVSKDNATKLL 264
Cdd:PRK03817  245 vlKVRDALKEGDIETlGELLTES---HWDLADNYevsCEELDFFVEFALELGAYGARLTGAgfGGSAIALVDKGKFESIG 321


                  ....*
gi 1179764616 265 KALTN 269
Cdd:PRK03817  322 EELLE 326
PRK14611 PRK14611
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
57-251 3.23e-04

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 184767 [Multi-domain]  Cd Length: 275  Bit Score: 41.28  E-value: 3.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616  57 IVKTALLLAPNLT----PHRIVVKSDIPLARGLGSSSSALLAGLAMANVLADMRLSNDSLLEQATALEGHpdnvAP-ALL 131
Cdd:PRK14611   63 IVYKALRLFERYTgidiNYSIFIEKNIPVGAGLGGGSSNAAVVLKYLNELLGNPLSEEELFELASSISAD----APfFLK 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616 132 GGSVAAFFDGEQVYHAPLSLPKDINFItfIPNYELLTTEARNAL-PAKMTFKDSVaasaisNTLTAALNAGDFNTARVLI 210
Cdd:PRK14611  139 GGFALGRGIGDKLEFLEKPISREITLV--YPNIKSSTGRVYSKVtKQILTNKEDL------NIIISLLREGEEKKIEEVI 210

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1179764616 211 EkDQFHEQARaHLAPHLKIIRDTahqLEIIG--TYLSGAGPTV 251
Cdd:PRK14611  211 E-NTLGEIAL-ELYPEIKEVYRF---LEYLGykPFVSGSGSSV 248
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 194-270 7.41e-03

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 35.14  E-value: 7.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179764616 194 LTAALNAGDFNTARVLIEKDQFHEQARAHLA---PHLKIIRDTAHQLeIIGTYLSGA--GPTVITLV-SKDNATKLLKAL 267
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAESLEPLLVVGilpPELDELLEALLEL-GLGAKLSGSggGPTVFALFkDEDDAEEVARAL 79


                  ...
gi 1179764616 268 TNM 270
Cdd:pfam08544  80 REA 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH