|
Name |
Accession |
Description |
Interval |
E-value |
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
9-447 |
2.01e-152 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 442.16 E-value: 2.01e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 9 RSNKAMTFFVCFLAALAGLLFGLDIGVIAGALPFIADEFQIT--------SHTQEWVVSSMMFGAAVGAVGSGWLSFKLG 80
Cdd:TIGR00879 20 GSTYWKVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFKFTsansdsysSSLWGLVVSIFLVGGFIGALFAGWLSDRFG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 81 RKKSLMIGAILFVAGSLFSAAAPN---VEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGA 157
Cdd:TIGR00879 100 RKKSLLIIALLFVIGAILMGLAAFalsVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 158 YLSDTA---FSYTGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLRLRDTSAEAKRELDEIR----- 229
Cdd:TIGR00879 180 YGFGSGkvsLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGEDKELLDELElidik 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 230 ---ESLQVKQSGWALFKENSNFRRAVFLGVLLQVMQQFTGMNVIMYYAPKIFELAGYTNTTeQMWGTVIVGLTNVLATFI 306
Cdd:TIGR00879 260 rsiEKRSVQPSWGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDH-AFLVSIIVGAVNFAFTFV 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 307 AIGLVDRWGRKPTLTLGFLVMAAGMGVLGTMMHIGIH--SPSAQYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLKGRD 384
Cdd:TIGR00879 339 AIFLVDRFGRRPLLLIGAAGMAICLFVLGILGASFVTgsSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRP 418
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1191214456 385 FGITCSTATNWIANMIVGATFLTMLNTLGNANTFWVYAALNVLFILLTLWLVPETKHVSLEHI 447
Cdd:TIGR00879 419 KGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
18-451 |
1.05e-142 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 416.29 E-value: 1.05e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 18 VCFLAALAGLLFGLDIGVIAGALPFIA---DEFQITSHTQE--------WVVSSMMFGAAVGAVGSGWLSFKLGRKKSLM 86
Cdd:pfam00083 1 VALVAALGGFLFGYDTGVIGAFLTLIDffkNFGLSKSVSSLaalsvlsgLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 87 IGAILFVAGSLFSAAAP---NVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTA 163
Cdd:pfam00083 81 IANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 164 FSYTGA---WRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLRLRdTSAEAKRELDEIRESLQVKQSG-- 238
Cdd:pfam00083 161 LNKTSNsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLR-GVPDVDRELDEIKDSLEAGQEAek 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 239 --WALFKENSNFRRAVFLGVLLQVMQQFTGMNVIMYYAPKIFELAGYTNTteqMWGTVIVGLTNVLATFIAIGLVDRWGR 316
Cdd:pfam00083 240 asWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDS---FLVTIIVGVVNFVFTFIAIFLVDRFGR 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 317 KPTLTLGFLVMAAGMGVLGTMMHIGIH-SPSAQYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNW 395
Cdd:pfam00083 317 RPLLLLGAAGMAICFVILGIVALLGVSkSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANW 396
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 1191214456 396 IANMIVGATFLTMLNTLGNANTFWVYAALNVLFILLTLWLVPETKHVSLEHIERNL 451
Cdd:pfam00083 397 LANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDELF 452
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
21-438 |
7.73e-133 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 387.70 E-value: 7.73e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 21 LAALAGLLFGLDIGVIAGALPFIADEFQI--TSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLF 98
Cdd:cd17315 1 VAALGGLLFGYDLGVINGALLYIAKDLGFglSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 99 SAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYT--GAWRWMLGV 176
Cdd:cd17315 81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSppGWWRLMFAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 177 IIIPAILLLIGVFFLPDSprwfaakrrfvdaervllrlrdtsaeakreldeireslqvkqsgwalfkensnfrRAVFLGV 256
Cdd:cd17315 161 AAVPALLQLLLMFFLPES-------------------------------------------------------RALLVGV 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 257 LLQVMQQFTGMNVIMYYAPKIFELAGytNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGT 336
Cdd:cd17315 186 GLQLLQQLTGINAVMYYAPTIFKSAG--GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAI 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 337 MMHIGIHSPSAQYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLGNAN 416
Cdd:cd17315 264 AFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAG 343
|
410 420
....*....|....*....|..
gi 1191214456 417 TFWVYAALNVLFILLTLWLVPE 438
Cdd:cd17315 344 VFIFFAAVCLLALVFVFFFVPE 365
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
17-438 |
2.95e-118 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 351.10 E-value: 2.95e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 17 FVCFLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGS 96
Cdd:cd17359 1 LISLVAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 97 LFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYTG-------- 168
Cdd:cd17359 81 LGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGgadwlgae 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 169 AWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRrfvdaervllrlrdtsaeakreldeireslqvkqsgwalfkensnf 248
Cdd:cd17359 161 GWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKG---------------------------------------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 249 RRAVFLGVLLQVMQQFTGMNVIMYYAPKIFELAGYTnTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMA 328
Cdd:cd17359 195 KPILIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFS-ENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMA 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 329 AGMGVLGTMMHIGIHSPSAQYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTM 408
Cdd:cd17359 274 ISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPIL 353
|
410 420 430
....*....|....*....|....*....|
gi 1191214456 409 LNTLGNANTFWVYAALNVLFILLTLWLVPE 438
Cdd:cd17359 354 LAAFGLAFTFLIFAVICVLAFLFVWKFVPE 383
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
22-438 |
1.74e-102 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 310.36 E-value: 1.74e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 22 AALAGLLFGLDIGVIAGALPFIADEFQITSHT---QEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLF 98
Cdd:cd17360 2 AGIGGFLFGYDTGVISGALLYIKDDLGEVVLStgwQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 99 SAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYT-GAWRWMLGVI 177
Cdd:cd17360 82 MAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLpGGWRWMLGLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 178 IIPAILLLIGVFFLPDSPRWfaakrrfvdaervllrlrdtsaeakreldeireslqvkqsgwalfKENsnfRRAVFLGVL 257
Cdd:cd17360 162 AVPAVLQFIGLLFLPESPRW---------------------------------------------PST---RRALIVGCG 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 258 LQVMQQFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLgtm 337
Cdd:cd17360 194 LQAFQQFSGINTVMYYSATILQMAGFKDNQNAIWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVIVALVVL--- 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 338 mhigihspsAQYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLGNANT 417
Cdd:cd17360 271 ---------AVWLALVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQAIGPYGT 341
|
410 420
....*....|....*....|.
gi 1191214456 418 FWVYAALNVLFILLTLWLVPE 438
Cdd:cd17360 342 FLLFAGLAVLGLIFIYFCVPE 362
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
16-446 |
5.02e-96 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 296.02 E-value: 5.02e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 16 FFVCFLAALAGLLFGLDIGVIAGALPFIADE----FQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAIL 91
Cdd:cd17358 1 LLATFVANLGSFSFGIAVGWSSPALPSLMSDnslsLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 92 FVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSytgaWR 171
Cdd:cd17358 81 CILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP----WR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 172 WMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLRLRDTSAEAKRELDEIRESLQ-----VKQSGWALFKENS 246
Cdd:cd17358 157 TLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQEELAelekeAKESSFSDLFQRK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 247 NfRRAVFLGVLLQVMQQFTGMNVIMYYAPKIFELAGytNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLV 326
Cdd:cd17358 237 Y-LKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAG--SGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 327 MAAGMGVLGTMMHIGIHSPSAQ---YFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGA 403
Cdd:cd17358 314 MGIGLLALGLYFYLQEHGALLSsvsWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTK 393
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 1191214456 404 TFLTMLNTLGNANTFWVYAALNVLFILLTLWLVPETKHVSLEH 446
Cdd:cd17358 394 TFPFLTLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLEE 436
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
11-449 |
4.76e-88 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 276.96 E-value: 4.76e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 11 NKAMTFFVCFLAALAGLLFGLDIGVIAGALP-----FIADEFQITSHTQEW---VVSSMMFGAAVGAVGSGWLSFKLGRK 82
Cdd:PRK10077 6 NSSYIFSITLVATLGGLLFGYDTAVISGTVEslntvFVAPQNLSESAANSLlgfCVASALIGCIIGGALGGYCSNRFGRR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 83 KSLMIGAILFVAGSLFSAA---------APNVEVLI---LSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMI 150
Cdd:PRK10077 86 DSLKIAAVLFFISALGSAWpefgftsigPDNTGYVPefvIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 151 TIGILGAYL--------SDTAFSYTGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLRLRDTSaEAK 222
Cdd:PRK10077 166 IFGQLVVYFvnyfiarsGDASWLNTDGWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNT-LAT 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 223 RELDEIRESLQVKQ-SGWALFkenSNFRRAVFLGVLLQVMQQFTGMNVIMYYAPKIFELAGyTNTTEQMWGTVIVGLTNV 301
Cdd:PRK10077 245 QALQEIKHSLDHGRkTGGKLL---MFGVGVIVIGVMLSVFQQFVGINVVLYYAPEIFKTLG-ASTDIALLQTIIVGVINL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 302 LATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGTMMHIGIhspsAQYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLK 381
Cdd:PRK10077 321 TFTVLAIMTVDKFGRKPLQIIGALGMAIGMFSLGTAFYTQA----PGIVALLSMLFYVAAFAMSWGPVCWVLLSEIFPNA 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1191214456 382 GRDFGITCSTATNWIANMIVGATFLTM------LNTLGNANTFWVYAALNVLFILLTLWLVPETKHVSLEHIER 449
Cdd:PRK10077 397 IRGKALAIAVAAQWIANYFVSWTFPMMdknswlVAHFHNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEEMEA 470
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
22-447 |
1.75e-82 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 259.59 E-value: 1.75e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 22 AALAGLLFGLDIGVIAGALPFI-------ADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVA 94
Cdd:cd17362 2 PALGGLLFGYDIGATSGALLSItspalsgTDWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 95 GSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYT-GAWRWM 173
Cdd:cd17362 82 GSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVvGGWRYM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 174 LGVIIIPAILLLIGVFFLPDSPRWfaakrrfvdaervllrlrdtsaeakreldeireslqvkqsgwalfkeNSNFRRAVF 253
Cdd:cd17362 162 YGLAAPPALLLGIGMWFLPPSPRW-----------------------------------------------QGNYRKPLI 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 254 LGVLLQVMQQFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGV 333
Cdd:cd17362 195 IGLGLVLFQQITGQPSVLYYAATIFKSAGFSAASDATLVSVGLGVFKLLMTIVAVLLVDKLGRRPLLLGGVSGMVVSLFL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 334 LGTMMHIGIHSPSAQ-YFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTL 412
Cdd:cd17362 275 LAAYNLFVQMGPAGLaWLSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRGRAIALAVLVNFGSNALVSLAFLPLQELI 354
|
410 420 430
....*....|....*....|....*....|....*
gi 1191214456 413 GNANTFWVYAALNVLFILLTLWLVPETKHVSLEHI 447
Cdd:cd17362 355 GLPGTFLGFGVIGVLALLFIYFTVPETKGLSLEEI 389
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
17-449 |
3.85e-71 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 230.60 E-value: 3.85e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 17 FVCFLAALAGLLFGLDIGVIAGAL---------PFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMI 87
Cdd:cd17356 1 LLCAFVSLGGFLFGYDTGSISGILnmksfqkyfADNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 88 GAILFVAGSLFS-AAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSY 166
Cdd:cd17356 81 GCVIYIIGAIIQvAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 167 TG---AWRWMLGVIIIPAILLLIGVFFLPDSPRWfaakrrfvdaervLLRLrdtsaeakreldeireslqvkqsgwalfk 243
Cdd:cd17356 161 LDgsaQWRIPLGLQIVWGLLLLIGMFFLPESPRW-------------LYRT----------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 244 ensnfrravFLGVLLQVMQQFTGMNVIMYYAPKIFELAGYTNtTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLG 323
Cdd:cd17356 199 ---------ILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTG-SSPLLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLIG 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 324 FLVMAAGMGVLGTMM--------HIGIHSPSAQYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNW 395
Cdd:cd17356 269 AAGMSICLFIYAAVGvrylipnpQSGTSNKSAGNGMIVFICLFIFSFATTWGPIAWVYVAEVFPLRVRSKGMALATAFNW 348
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1191214456 396 IANMIVGATFLTMLNTLGnANTFWVYAALNVLFILLTLWLVPETKHVSLEHIER 449
Cdd:cd17356 349 LWNFLISFFTPFIIGSIG-FKYYYIFAGCNLLAFIVVFFFVPETKGLTLEEIDE 401
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
16-445 |
7.24e-71 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 230.53 E-value: 7.24e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 16 FFVCFLAALAGLLFGLDIGVIAGALP---FIAD-EFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAIL 91
Cdd:cd17433 1 FLATFAAVLGPLSFGFVLGYSSPAIPslqRIADpALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 92 FVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSytgaWR 171
Cdd:cd17433 81 FIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLD----WR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 172 WMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLRLRDTSAEAKRELDEIRESLQVKQSGWALFK-ENSNFRR 250
Cdd:cd17433 157 WLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPDQGWEWECIGIEQSFHLEEQSFSLALlKQPGIYK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 251 AVFLGVLLQVMQQFTGMNVIMYYAPKIFELAGYTNTTeqmWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAG 330
Cdd:cd17433 237 PLIIGVSLMAFQQLTGINAVMFYAETIFEEAKFKDSS---VASVIVAAIQVLFTAVAALIMDRAGRKVLLVLSGVVMVFS 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 331 MGVLGtmmhigihspsaqYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLN 410
Cdd:cd17433 314 TAAFG-------------WLAVGSMGFFIAGFAVGWGPIPWLVMSEIFPLHVRGVASGICVLTNWLMAFLVTKEFSSLME 380
|
410 420 430
....*....|....*....|....*....|....*
gi 1191214456 411 TLGNANTFWVYAALNVLFILLTLWLVPETKHVSLE 445
Cdd:cd17433 381 VLSSYGTFWLFSAFCAFSVLFTLFCVPETKGKTLE 415
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
57-440 |
1.26e-68 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 225.60 E-value: 1.26e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 57 VVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSL---FSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEI 133
Cdd:cd17357 54 IVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLlmfLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEI 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 134 APEKIRGSMISMYQLMITIGIL-GAYLS-DTAFSYTGAWRWMLGVIIIPAILLLIGVFFLPDSPRW-FAAKRRFVDAERV 210
Cdd:cd17357 134 SPSELRGALGSLTQIGVTLGILlGQVFGlPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFlLISKGDEEEAEKS 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 211 LLRLRDTSAEAKRELDEIR-ESLQVKQSG----WALFKENSNfRRAVFLGVLLQVMQQFTGMNVIMYYAPKIFELAGYTn 285
Cdd:cd17357 214 LKFLRGIEDDVDQELEEIKkESEQMGDQKqvslMQLLRDPSL-RLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFS- 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 286 TTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGTMMHIGIHSPSAQYFAIAMLLMFIVGFAMS 365
Cdd:cd17357 292 PQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQNSWMSYGCIVAIFLFIFFFAIG 371
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1191214456 366 AGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLGNAnTFWVYAALNVLFILLTLWLVPETK 440
Cdd:cd17357 372 LGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGF-VFIIFAIPCALFLLYLYRYLPETK 445
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
21-438 |
4.31e-68 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 222.51 E-value: 4.31e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 21 LAALAGLLFGLDIGVIAGAL---PFIADEF------QITSHTQEW----------VVSSMMFGAAVGAVGSGWLSFKLGR 81
Cdd:cd17361 1 VAALGGLIFGYDIGISGGVTsmdPFLEKFFpsvyekKKGASENNYckyddqllqlFTSSLYLAGLVASLLASYVTRKWGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 82 KKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSD 161
Cdd:cd17361 81 KPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANLIN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 162 TAFSYTGA--WRWMLGVIIIPAILLLIGVFFLPDSPrwfaakrrfvdaervllrlrdTSAEakreldeireslqvkqsgw 239
Cdd:cd17361 161 YGTSKIKPngWRLSLGLAAVPALILLLGSLFLPETP---------------------NSPQ------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 240 alfkensnfrraVFLGVLLQVMQQFTGMNVIMYYAPKIFELAGYTNTTEQMwGTVIVGLTNVLATFIAIGLVDRWGRKPT 319
Cdd:cd17361 201 ------------LVIAILIPFFQQLTGINVIMFYAPVLFQTLGFGSDASLI-SAVITGAVNVVSTLVSIYLVDRFGRRFL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 320 LTLGFLVMAAGMGVLGTMMHI-----GIHSPSAQYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATN 394
Cdd:cd17361 268 LLEGGVQMLASQVAIGILLAVkfgdgGELPKAYAIAVVVLICLYVAAFAWSWGPLGWLVPSEIFPLETRSAGQSLTVAVN 347
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1191214456 395 WIANMIVGATFLTMLNTLgNANTFWVYAALNVLFILLTLWLVPE 438
Cdd:cd17361 348 FLFTFVIAQAFLSMLCAM-KFGIFLFFAGWVVVMSLFVYFLLPE 390
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
21-447 |
1.59e-63 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 210.34 E-value: 1.59e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 21 LAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSA 100
Cdd:cd17437 1 LASLNSILLGYDIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 101 AAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYTGA---WRWMLGVI 177
Cdd:cd17437 81 VAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFSGLPLhvgWRLMLGVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 178 IIPAILLLIGVFFLPDSPRWFAAKRRFVdaervllrlrdtsaeakreldeireslqvkqsgwalfkensnfrrAVFLGVl 257
Cdd:cd17437 161 AVPSLFLAIGVLAMPESPRWTPAVRRML---------------------------------------------IAALGI- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 258 lQVMQQFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGTM 337
Cdd:cd17437 195 -HFFQQASGIDAVVLYSPRIFKKAGIKSKDKLLLATVAVGVTKTLFILVATFLLDKVGRRPLLLTSTGGMTLSLTALATS 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 338 MHI----GIHSPSAQYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLG 413
Cdd:cd17437 274 LTFidrnGGGLTWALVLAITAVCSFVAFFSIGAGPITWVYSSEIFPLRLRAQGASLGVVVNRLMSGTVSMTFLSMSKAIT 353
|
410 420 430
....*....|....*....|....*....|....
gi 1191214456 414 NANTFWVYAALNVLFILLTLWLVPETKHVSLEHI 447
Cdd:cd17437 354 TGGTFFLFAGVAAAAWVFFYFFLPETKGKSLEEI 387
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
17-440 |
2.15e-61 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 206.42 E-value: 2.15e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 17 FVCFLAALAGLLFGLDIGVIAGALPFIaDEFQITSH-------------TQEWVVSSMMF--GAAVGAVGSGWLSFKLGR 81
Cdd:cd17431 1 FAVFVAVLGSLQFGYNTGVINAPQKVI-EEFYNKTLgdrygepispetlTTLWSLSVAIFsvGGMIGSFSVGLFVNRFGR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 82 KKSLMIGAILFVAGSL---FSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAY 158
Cdd:cd17431 80 RNSMLYNNLLAFAGAAlmgLSKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 159 L--SDTAFSYTGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFV-DAERVLLRLR---DTSAEAKRELDEIRESL 232
Cdd:cd17431 160 IfgLEFILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLLINRNEEeEAKSVLKKLRgttDVSEDIQEMKEESRQMM 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 233 QVKQSGWALFKENSNFRRAVFLGVLLQVMQQFTGMNVIMYYAPKIFELAGytnTTEQMWGTVIVGLTNVLATFIAIGLVD 312
Cdd:cd17431 240 REKKVTILELFRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAG---VQQPVYATIGAGVVNTIFTVVSLFLVE 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 313 RWGRKpTLtlgFLVMAAGMGVLGTMMHIGI----HSPSAQYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLKGRDFGIT 388
Cdd:cd17431 317 RAGRR-TL---HLIGLGGMAICAILMTIALllleGYPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMA 392
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 1191214456 389 CSTATNWIANMIVGATFLTMLNTLGNAnTFWVYAALNVLFILLTLWLVPETK 440
Cdd:cd17431 393 VAGFSNWTSNFIVGMCFQYIANLCGPY-VFIIFTVFLLTFFIFTYFKVPETK 443
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
22-447 |
3.32e-59 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 198.87 E-value: 3.32e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 22 AALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAA 101
Cdd:cd17435 6 AAVSGLLVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVC 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 102 APNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAF-SYTGAWRWMLGVIIIP 180
Cdd:cd17435 86 SVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFaNVSNGWKYMFGLVIPL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 181 AILLLIGVFFLPDSPRWFAAKrrfvdaervllrlrdtsaeakreldeireslqvkqsgwalfkenSNFRRAVFLGVLLQV 260
Cdd:cd17435 166 AALQAIAMYFLPPSPRFLVMK--------------------------------------------DNMRARLLIGLTLVF 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 261 MQQFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGTmmhi 340
Cdd:cd17435 202 FVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPAIFLVDKVGSKTFLCIGSSVMAVSLVTMGL---- 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 341 gihspsaqYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQP--LKGRDFGITcsTATNWIANMIVGATFLTMLNTLGNANTF 418
Cdd:cd17435 278 --------WLSLASLLVYVAAFSIGLGPMPWLVLSEIFPggIRGRAMALT--SSMNWGINLLISLTFLTVTELIGLPWVC 347
|
410 420
....*....|....*....|....*....
gi 1191214456 419 WVYAALNVLFILLTLWLVPETKHVSLEHI 447
Cdd:cd17435 348 FIYTAMSLASLVFVIMFVPETKGCSLEQI 376
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
24-447 |
5.84e-51 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 176.92 E-value: 5.84e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 24 LAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAP 103
Cdd:cd17436 8 LGGLTFGYELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 104 NVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYTG-AWRWMLGVIIIPAI 182
Cdd:cd17436 88 SFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSNVLtGWRYMFGLAIIPAA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 183 LLLIGVFFLPDSPRWFAAKrrfvdaervllrlrdtsaeakreldeireslqvkqsgwalfkenSNFRRAVFLGVLLQVMQ 262
Cdd:cd17436 168 IQFASILLLPKKPEVLNIK--------------------------------------------DNMRRRTLVGLGLVLFQ 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 263 QFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGTmmhigi 342
Cdd:cd17436 204 QFTGQPNVLCYASTIFRSVGFQSNSSAVLASVGLGVVKVIATLLAMLFADRAGRRSLLIAGCSVMAVSVSGIGL------ 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 343 hspsaqYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLGNANTFWVYA 422
Cdd:cd17436 278 ------WITLLCLMAFVSAFSIGFGPMTWLVLSEIYPADIRGRAFSFCNSFNWAANLLITLSFLDLIDVIGLSWTFLLYG 351
|
410 420
....*....|....*....|....*
gi 1191214456 423 ALNVLFILLTLWLVPETKHVSLEHI 447
Cdd:cd17436 352 VVGVAGVVFIYLFVPETKGQSLEEI 376
|
|
| MFS_GLUT6_Class3 |
cd17434 |
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
16-445 |
1.33e-47 |
|
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340992 [Multi-domain] Cd Length: 417 Bit Score: 169.24 E-value: 1.33e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 16 FFVCFLAALAGLLFGLDIGVIAGALPFIADE----FQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAIL 91
Cdd:cd17434 1 FLAVFSAVLGNFSFGYALVYTSPVIPALEQGddprLHLNVHQISWFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 92 FVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYlsdtAFSYTGAWR 171
Cdd:cd17434 81 SALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGACPQIMAVFGSLALY----ALGLLLPWR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 172 WMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLRLRDTSAEAKRELDEIRESLQVKQS--GWALFKENSnFR 249
Cdd:cd17434 157 WLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKALAWLRGPNTDYMTEFEQIKDNIRKQSSrlSWAELKTPS-YY 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 250 RAVFLGVLLQVMQQFTGMNVIMYYAPKIFELAGYtnTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAA 329
Cdd:cd17434 236 KPILIAVVMRFLQQLTGITPILVYLEPIFHLTAV--ILEPKYDAALVGAVRLLSVAIAASLMDKAGRKILLFTSAFLMFA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 330 GMGVLGTMMHIGIhspsaqyfaiamlLMFIVGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTML 409
Cdd:cd17434 314 ANLSMGLIPLIAA-------------MLFIMGYAMGWGPITWLLMSEILPLKARGVASGLCVVVSWITAFVLTQLFLPVV 380
|
410 420 430
....*....|....*....|....*....|....*.
gi 1191214456 410 NTLGNANTFWVYAALNVLFILLTLWLVPETKHVSLE 445
Cdd:cd17434 381 VTFGLQVPFLFFAAVCAVSIIFTACCVPETKGRTLE 416
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
57-440 |
4.91e-46 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 165.87 E-value: 4.91e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 57 VVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSL---FSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEI 133
Cdd:cd17432 55 TVSIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAIlmgLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGES 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 134 APEKIRGSMISMYQLMITIGILGAY---LSDTAFSYTGaWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVD-AER 209
Cdd:cd17432 135 APKNLRGAVGLVPAIFITLGILLGQvlgLRELLGNEEG-WPLLLALTGVPALLQLLTLPFFPESPRYLLIEKGDEEaARK 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 210 VLLRLRDTSaEAKRELDEIRESLQVKQ-----SGWALFKENSnFRRAVFLGVLLQVMQQFTGMNVIMYYAPKIFELAGYT 284
Cdd:cd17432 214 ALQRLRGKE-DVDDEMEEMLEEQRAEKgvgtvSVLELFRDRS-VRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIP 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 285 NTTEQmWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGTMMHIGIHSPSAQYFAIAMLLMFIVGFAM 364
Cdd:cd17432 292 EDKIQ-YVTVGTGACEVLATITCVLVIERLGRRPLLIGGFGLMAVWCAVLTVALSLQNTVSWMPYLSIVCIFAYIASFGI 370
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191214456 365 SAGPLIWVLCSEI--QPLKGRDFGITCStaTNWIANMIVGATFLTMLNTLGnANTFWVYAALNVLFILLTLWLVPETK 440
Cdd:cd17432 371 GPAGVPFILTTEIfdQSSRPAAFMVAGS--LNWLSNFLVGLLFPFIQEGLG-AYCFLVFAVICLLTAIYIFFVLPETK 445
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
20-398 |
5.79e-36 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 135.87 E-value: 5.79e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 20 FLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFS 99
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 100 AAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYTGAWRWMLGVIII 179
Cdd:COG2814 93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 180 PAILLLIGV-FFLPDSPRwfAAKRRFVDAERVLLRlrdtsaeakreldeireslqvkqsgwalfkensnfRRAVFLGVLL 258
Cdd:COG2814 173 LALLALLLLlRLLPESRP--AARARLRGSLRELLR-----------------------------------RPRLLLLLLL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 259 QVMQQFTGMNVIMYYAPKIFELAGYTnTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGTmm 338
Cdd:COG2814 216 AFLLGFGFFALFTYLPLYLQEVLGLS-ASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL-- 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1191214456 339 higihspsAQYFAIAMLLMFIVGFAMS-AGPLIWVLCSEIQPLKGRDFGITCSTATNWIAN 398
Cdd:COG2814 293 --------AGSLWLLLLALFLLGFGFGlLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
5-221 |
3.86e-30 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 118.76 E-value: 3.86e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 5 KKQGRSNKAMTFFVCFLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKS 84
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 85 LMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAF 164
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1191214456 165 SYTGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLRLRDTSAEA 221
Cdd:COG0477 162 VAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLAL 218
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
20-433 |
7.68e-26 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 108.02 E-value: 7.68e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 20 FLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFS 99
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 100 AAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYTGAWRWMLGVIII 179
Cdd:cd17324 82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 180 PAILLLIGVFFLpdsprwfaakrrfvdaervllrLRDTSAEAKRELDEIREslqvkqsgWALFKENSNFRRAVFLGVLLq 259
Cdd:cd17324 162 LALLAALLLWRL----------------------LPSLPPKKPGSLGLLSS--------LLLLLRNPRLRLAYLITFLL- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 260 vmqqFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGTmmh 339
Cdd:cd17324 211 ----FGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLL--- 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 340 igihspsAQYFAIAMLLMFIVGFAM-SAGPLIWVLCSEIQPlKGRDFGITCSTATNWIANMIVGATFLTMLNTLGNANTF 418
Cdd:cd17324 284 -------GPSPLLLLVGLVLWGLGFfAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVG 355
|
410
....*....|....*
gi 1191214456 419 WVYAALNVLFILLTL 433
Cdd:cd17324 356 WVGAALLLLALLLAL 370
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-440 |
5.63e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 105.72 E-value: 5.63e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 9 RSNKAMTFFVCFLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIG 88
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 89 AILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYTG 168
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 169 AWRWMLGViiipailllIGVFFLpdsprwfaakrrfvdaervllrlrdtsaeakreldeireslqvkqsGWALFKensnf 248
Cdd:COG2271 162 GWRAAFLI---------LGLPGL----------------------------------------------LLALLR----- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 249 rravFLGVLLQVMQQFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGR--KPTLTLGFLV 326
Cdd:COG2271 182 ----FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLL 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 327 MAAGMGVLGTMMHIgihspsaqyfAIAMLLMFIVGFAMSAG-PLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATF 405
Cdd:COG2271 258 AALALLLLALLPSP----------ALAIALLFLAGFGLGGAfGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLV 327
|
410 420 430
....*....|....*....|....*....|....*
gi 1191214456 406 LTMLNTLGNANTFWVYAALNVLFILLTLWLVPETK 440
Cdd:COG2271 328 GYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
20-434 |
1.50e-24 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 104.22 E-value: 1.50e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 20 FLAALAGLLFGLDIGVIAGALPFIADEF--QITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSL 97
Cdd:cd17316 2 LLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 98 FSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYTG----AWRWM 173
Cdd:cd17316 82 LIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRIL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 174 LGVIIIPAILLligvfflpdsprwfaakrrfvdaerVLLRLRdtsaeakreldeireslqvkqsgwalfkensnfrravF 253
Cdd:cd17316 162 FLIGALPALLA-------------------------LLLRRR-------------------------------------T 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 254 LGVLLQVMQQFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGV 333
Cdd:cd17316 180 LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALP 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 334 LGTmmhigIHSPSAQYFAIAMLLMFIVGFAMSAGPLIWVlcSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLG 413
Cdd:cd17316 260 LFY-----LLSGSPTLLLLLLFILSFFVGGVWGALYAYL--AELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG 332
|
410 420
....*....|....*....|.
gi 1191214456 414 NANTFWVYAALNVLFILLTLW 434
Cdd:cd17316 333 GTGVPALILALLAIVALIVAL 353
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
22-433 |
3.54e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 103.66 E-value: 3.54e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 22 AALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAA 101
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 102 APNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-ILGAYLSDTAFSYTGA-WRWMLGVIII 179
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGgILGPLLGGILASSLGFgWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 180 PAILLLIGVFFLPDSPRWfaakrrfvdaervllrlrdtsaeAKRELDEIRESLQVKQSGWALFKensnfRRAVFLGVLLQ 259
Cdd:cd06174 161 LALLAAILLLLVVPDPPE-----------------------SARAKNEEASSKSVLKLLKRVLK-----NPGLWLLLLAI 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 260 VMQQFTGMNVIMYYAPKIFELAGYTNTTEqMWGTVIVGLTNVLATFIAIGLVDR-WGRKPTLTLGFLVMAAGMGVLGTMM 338
Cdd:cd06174 213 FLVNLAYYSFSTLLPLFLLDLGGLSVAVA-GLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAP 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 339 HigihspsaqyFAIAMLLMFIVGFAMSAG-PLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLN-TLGNAN 416
Cdd:cd06174 292 S----------LLLLLLLLLLLGFGLGGLlPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTG 361
|
410
....*....|....*..
gi 1191214456 417 TFWVYAALNVLFILLTL 433
Cdd:cd06174 362 AFLVLAVLLLLAAILLL 378
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
15-367 |
4.45e-24 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 103.59 E-value: 4.45e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 15 TFFVCFLAALaglLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVA 94
Cdd:TIGR00895 18 AIILSFLIML---MDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 95 GSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-ILGAYLSDTAFSYTGaWRWM 173
Cdd:TIGR00895 95 FTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGaAVGGFLAGWLIPVFG-WRSL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 174 LGVIIIPAILLLIGV-FFLPDSPRWFAAKRRFVDAERVLLRLRDTSAEAKRELDEIRESLQVKQSGWALFKENSNFRRAV 252
Cdd:TIGR00895 174 FYVGGIAPLLLLLLLmRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTARITV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 253 FLGVLlqvmqqfTGMNVIMYYA-----PKIFELAGYtNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTlTLGFLVM 327
Cdd:TIGR00895 254 LLWLL-------YFMLLVGVYFltnwlPKLMVELGF-SLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVT-ALLLLLG 324
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1191214456 328 AAGMGVLGTMMHIgihspsaqyFAIAMLLMFIVGFAMSAG 367
Cdd:TIGR00895 325 AVFAVLVGSTLFS---------PTLLLLLGAIAGFFVNGG 355
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
59-445 |
1.85e-23 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 102.79 E-value: 1.85e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 59 SSMMFGAAVGAVGSGWLSFKLGRKKSLMIgAILFVAGS-LFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEK 137
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLL-STLVTAVSgVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKK 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 138 IRGSMISMYQLMITIGILG----AYLsdtafsyTGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLR 213
Cdd:TIGR00898 213 QRAIVGTLIQVFFSLGLVLlplvAYF-------IPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQR 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 214 LRDT-----SAEAKRELDEIRESLQVKQSGWALFKENSNFRRavflgVLLQVMQQFTGMNVIMYYAPKIFELAG---Ytn 285
Cdd:TIGR00898 286 IAKIngkklPAEVLSLSLEKDLSSSKKQYSFLDLFRTPNLRK-----TTLCLMMLWFTTAFSYYGLVLDLGNLGgniY-- 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 286 tteqmWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGTMmhigihsPSAQYFAIAMLLMFIVGFAMS 365
Cdd:TIGR00898 359 -----LDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFV-------PVDLYFLRTALAVLGKFGITS 426
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 366 AGPLIWVLCSEIQPLKGRDFGI-TCSTATNwianmiVGATFLTMLNTLGNANTFW---VYAALNVLFILLTLWLvPETKH 441
Cdd:TIGR00898 427 AFQMVYLYTAELYPTVVRNLGVgVCSTMAR------VGSIISPFLVYLGEKWLFLplvLFGGLALLAGILTLFL-PETKG 499
|
....
gi 1191214456 442 VSLE 445
Cdd:TIGR00898 500 VPLP 503
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
23-436 |
1.78e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 92.64 E-value: 1.78e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 23 ALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAA 102
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 103 PNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYTGAWRWMLGVIIIPAi 182
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 183 llligvfflpdsprwfaakrrFVDAERVLLRLRDTSAEAKREldeiRESLQVKQSGWALFKENSNFRRAVFLGVLLQVMQ 262
Cdd:cd17325 161 ---------------------LLALVLALLLLPEPRPPPNKR----AVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 263 QFTGMnVIMYYAPKIFELagytntTEQMWGTV--IVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGTMmhi 340
Cdd:cd17325 216 GALEP-FLPLYAAELGGL------SPAQIGLLfgAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA--- 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 341 gihsPSAQYFAIAMLLMFIvGFAMSAGPLIWVLCSEIQP-LKGRDFGITCSTatnWIANMIVGATFLTML-NTLGNANTF 418
Cdd:cd17325 286 ----TSFWLLLLLLALLGL-GLGLVFPATLALLADIVPPeGRGTAMGLFNTA---FSLGMVLGPLLGGFLyDAFGFATPF 357
|
410
....*....|....*...
gi 1191214456 419 WVYAALNVLFILLTLWLV 436
Cdd:cd17325 358 LAAAALLLLAAVLFLLLR 375
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
51-439 |
3.48e-20 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 91.96 E-value: 3.48e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 51 SHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEV------LILSRVLLGLAVGVASY 124
Cdd:cd17364 38 SGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPlgvmgwLIFFRFLLGIGIGGDYP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 125 TAPLYLSEIAPEKIRGSMISMYQLMITIGIL--------------GAYLSDTAFSYTGAWRWMLGVIIipaillligvff 190
Cdd:cd17364 118 LSATIMSEYANKKRRGALIAAVFAMQGFGILagaivtlilsaifeHPLPAGTYHHADLVWRIVLGLGA------------ 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 191 lpdsprwfaakrrfVDAERVLLRLRDTSAEAkreldeireslqvkqSGWALFkENSNFRRAVFLGVLLQVMQQFTGMNVI 270
Cdd:cd17364 186 --------------IPALSVLYFRKHLLGTA---------------GTWFLL-DIAFYGQNLFQSTIISAIGFSKTMNAY 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 271 MyyapkifelAGYTNTTEQmwgTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGTMMHIGIHSPsAQYF 350
Cdd:cd17364 236 Q---------ELFNIAVGQ---LIIALAGTVPGYWFTVFLIDRIGRKKIQMMGFFGMTIFLLILAGPYDHWKIST-IGFF 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 351 AIAMLLMFIvgFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLGNANTFWVYAALNVLFIL 430
Cdd:cd17364 303 VLYGLTFFF--SNFGPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGII 380
|
....*....
gi 1191214456 431 LTLWLVPET 439
Cdd:cd17364 381 LTLLFPEEK 389
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-400 |
2.19e-19 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 89.01 E-value: 2.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 23 ALAGLLFGLDIGVIAGALP-FIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAA 101
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 102 APNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYTGAWRWMLGVIIIPA 181
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 182 ILLLIGVFFLPDSPrwfaakrrfvdaervllrlrdtsaeakreldEIRESLQVKQSGWALFKENSNFRRAVFLGVLLQVM 261
Cdd:pfam07690 162 LLAAVLLLLPRPPP-------------------------------ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 262 QQFTGMNVIMYYAPKIFELAGYTNTTEqMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLgtmmhig 341
Cdd:pfam07690 211 LFGFAFFGLLTYLPLYQEVLGLSALLA-GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGL------- 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 342 IHSPSAQYFAIAMLLMFIVGFAMS-AGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMI 400
Cdd:pfam07690 283 LLLSLTLSSLWLLLALLLLGFGFGlVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
22-366 |
7.36e-19 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 88.02 E-value: 7.36e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 22 AALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAA 101
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 102 APNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYLSDTAfsytgAWRWMLGV 176
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLApaigpTLGGWLTDNL-----SWRWIFYI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 177 iiiPAILLLIGVFFLPdsprwfaakrrfvdaervLLRLRdtsaeakreldeireslqvkqsgwaLFKeNSNFRRAVFLGV 256
Cdd:cd17503 156 ---NLPIGILALLLAP------------------LLDLR-------------------------LFK-DRNFTLGLLLSF 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 257 LLQVmqqftGMNVIMYYAPKIFE-LAGYTnTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVlg 335
Cdd:cd17503 189 LLGL-----GLFGAMFLLPLYLQnVLGYS-AFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLL-- 260
|
330 340 350
....*....|....*....|....*....|.
gi 1191214456 336 tMMHIGIHSPSAQYFAIAMLLMFIVGFAMSA 366
Cdd:cd17503 261 -LAFLTPDTSLWLIILPLFIRGLGMGLVFMP 290
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
23-369 |
1.93e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 83.76 E-value: 1.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 23 ALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAA 102
Cdd:cd17321 2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 103 PNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYLSDTAfsytgAWRWMLGVi 177
Cdd:cd17321 82 PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGaalgpLLGGLLLELF-----GWRWIFLI- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 178 iiPAILLLIGVFFLPdsprwfaakrrfvdaervllrlrdtsaeakreldeireslqvkqsgwalfkensNFRRAVFLGVL 257
Cdd:cd17321 156 --NVPIGLVALLLAR------------------------------------------------------TFSGAVLAAFL 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 258 LqvmqqFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVlgtM 337
Cdd:cd17321 180 L-----GAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLL---L 251
|
330 340 350
....*....|....*....|....*....|..
gi 1191214456 338 MHIGIHSPSAQYFAIAMLLMFivGFAMSAGPL 369
Cdd:cd17321 252 ALLGADSSVWLLLPGLVLLGL--GLGLFATPL 281
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-443 |
1.95e-17 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 83.78 E-value: 1.95e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 18 VCFLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSL 97
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 98 FSAAAPNVEVLILSRVLLGLAVGvASYTAPL-YLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYTGAWRWMLGV 176
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGG-GSFAVGIaLVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 177 IIIPAILLLIGV-FFLPDSPRwfaakrrfvdaervllrlrDTSAEAKRELDEIRESLQVKQSgWALFkensnfrrAVFLG 255
Cdd:COG2223 165 LGILLLVVAVLAwLFLRDPPA-------------------GAAAAAKASLRDQLEALRDPRF-WLLS--------LLYFG 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 256 VllqvmqqFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLG 335
Cdd:COG2223 217 T-------FGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLA 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 336 TMMHIgihspsaqyFAIAMLLMFIVGFAMSAG-PLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLGN 414
Cdd:COG2223 290 LALGS---------LWLFLVLFLLLGLALGGGnGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGS 360
|
410 420 430
....*....|....*....|....*....|
gi 1191214456 415 -ANTFWVYAALNVLFILLTLWLVPETKHVS 443
Cdd:COG2223 361 yTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
19-439 |
2.36e-16 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 80.42 E-value: 2.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 19 CFLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLF 98
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 99 SAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDT-AFSYTG---AWRWML 174
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAAlLFPLLPpeiAWRVLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 175 GVIIIPAILLLIGVFFLPDSPRWFAAKRRfvdaervllrlrdtsaeakreldeiRESLQVKQSGWALFkeNSNFRRAVFL 254
Cdd:cd17371 161 LLGALPALLVLFIRRFVKEPPQWQAARAA-------------------------RRHFADRPSLRELF--SPPLLRTTLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 255 GVLLQVMQQFTGMNVIMYYaPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMgVL 334
Cdd:cd17371 214 ASLLATGALGGYYGITTWL-PSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISI-LL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 335 GTMMHIGihspsaqyFAIAMLLMFIVGFAMSAGPLIW-VLCSEIQPLKGRDfgiTCSTATNWIANMI-----VGATFLTM 408
Cdd:cd17371 292 YFFLPLS--------PTLILILGFPLGFFASGPFSGMgAYLTELFPTAVRA---TAQGFCYNVGRIIgalfpFLVGFLAT 360
|
410 420 430
....*....|....*....|....*....|.
gi 1191214456 409 LNTLGNAntFWVYAALNVLFILLTLWLVPET 439
Cdd:cd17371 361 SGSLGTA--IAVFAAVYYIAGLVLALLLPET 389
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
17-174 |
1.68e-15 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 77.63 E-value: 1.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 17 FVCFLAALaglLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGS 96
Cdd:cd17365 2 ALCFLIIV---LDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFT 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191214456 97 LFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-ILGAYLSdTAFSYTGAWRWML 174
Cdd:cd17365 79 LLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGaALGGFLA-AALIPAFGWRSVF 156
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
24-435 |
3.41e-15 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 76.45 E-value: 3.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 24 LAGLLFGLDIGVIAGALPFIADEFQITSHTQeWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAP 103
Cdd:cd17502 3 LALFLAALDQTIVATALPTIVAEFGGLSLVS-WVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 104 NVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYLSDTAfsytgAWRWmlgvii 178
Cdd:cd17502 82 NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIAsvagpLIGGAFTDHL-----SWRW------ 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 179 ipaillligVFFlpdsprwfaakrrfvdaervllrlrdtsaeakreldeiresLQVKQSGWALFkensnFRRAVFLGVLL 258
Cdd:cd17502 151 ---------CFY-----------------------------------------INLPIGGLALA-----LLRTILLSSIF 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 259 QVMQQFtGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGR-KPTLTLGFLVMAAGMGVLgTM 337
Cdd:cd17502 176 GFLFGG-ALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRyKPLIVIGTILMSVGAGLL-TT 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 338 MHIGIHspsaqyFAIAMLLMFIVGFAMSAGPLIWVLCSEIQpLKGRDFGItcSTATNWIANMIVGATFLTMLntlgnaNT 417
Cdd:cd17502 254 LTLDTS------KWLLIGYLILLGLGLGIGFQQPLVAVQNA-VPPADVGV--ATATNTFFRSLGGTLGVAIT------DV 318
|
410
....*....|....*...
gi 1191214456 418 FWVYAALNVLFILLTLWL 435
Cdd:cd17502 319 FLVALALAALAFLLSLFL 336
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
23-173 |
1.72e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 74.54 E-value: 1.72e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 23 ALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAA 102
Cdd:cd17504 2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 103 PNVEVLILSRVLLGLAVGVasytAPLYLS----EIAPEKIrGSMISMYQLMITIG-----ILGAYLSDTAfsytgAWRWM 173
Cdd:cd17504 82 PNLPVLIAGRALQGIGGAV----FPLAFAlvreEFPPERV-PVAQGILSATFGIGagiglPLGGWIVQHL-----GWRWI 151
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
15-173 |
1.52e-13 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 72.41 E-value: 1.52e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 15 TFFVCFLAALAGLLfglDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVA 94
Cdd:TIGR00711 3 LTIVLMLGTFMAVL---DSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 95 GSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYLSDtafSYTga 169
Cdd:TIGR00711 80 GSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVApalgpTLGGWIIE---NYH-- 154
|
....
gi 1191214456 170 WRWM 173
Cdd:TIGR00711 155 WRWI 158
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
43-435 |
1.87e-13 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 71.07 E-value: 1.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 43 IADEFQIT---SHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLAV 119
Cdd:cd17317 13 IVTEWDLVcdrDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 120 GVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILG----AYLSDTafsytgaWRWMLgviiipAILLLIGVFFLPDSp 195
Cdd:cd17317 93 AGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLlallAYLIRD-------WRWLQ------LAISLPGLLFLLLL- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 196 rWFAAKRRFVdaervllrlrdtsaeakreldeireslqvkqSGWALFkensnfrravflgvllqvmqqftgMNVIMYY-- 273
Cdd:cd17317 159 -WWLPRRTII-------------------------------VGLIWF------------------------VTSLVYYgl 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 274 APKIFELAGYtntteQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLtlgFLVMAAGMGVLGTMMHIGIHSPSAqyfaiA 353
Cdd:cd17317 183 SLNSSNLGGN-----LYLNFFLSGLVEIPAYFLALLLLDRLGRRWTL---SGSLLLAGLACLVTALLPDDENTL-----A 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 354 MLLMFIVGFAMSAG-PLIWVLCSEIQPLKGRDFGI-TCSTATNWIAnmiVGATFLTMLNTLGNANTFWVYAALNVLFILL 431
Cdd:cd17317 250 LTLALVGKFAISAAfSVIYLYTAELYPTVVRNTGVgLCSTVARVGA---ILAPFIVLLGKIGPLLPLIIFGVLALLGGLL 326
|
....
gi 1191214456 432 TLWL 435
Cdd:cd17317 327 TLLL 330
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
9-435 |
3.30e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 71.04 E-value: 3.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 9 RSNKAMTFFVCFLAALAGLLFGLdigvIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIG 88
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATAL----WGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 89 AILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKiRGSMISMYQLMITIG-ILGAYLSDTAFSYT 167
Cdd:COG0738 80 LLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGaLLGPLLGGLLILLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 168 GAWRWMLGVIIIPAILLLIGVFFLpdsprwfaakrrfvdaervLLRLRDTSAEAKRELDEIRESLQVKQSGWALFkensn 247
Cdd:COG0738 159 LSLSWHLPYLILAVLLLLLALLFL-------------------RSKLPEIEEEEEEAAGSAASLKSLLKNPRLLL----- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 248 FRRAVFLGVLLQVMqqftgmnvIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVM 327
Cdd:COG0738 215 GGLAIFLYVGAEGA--------IGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLA 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 328 AAGMGVLGTmmhigihspsAQYFAIAMLLMFIVGFAMSAG-PLIWVLCSEIQPLKgrdfgiTCSTATNWIANMIVGATFL 406
Cdd:COG0738 287 AVGLLLALL----------APGPWLALIGLALVGLGLSLMfPTIFSLALDGLGKR------TAAAVSAVLIMGIVGGAIG 350
|
410 420 430
....*....|....*....|....*....|....
gi 1191214456 407 TML-----NTLGNANTFWVYAALNVLFILLTLWL 435
Cdd:COG0738 351 PPLigflaDAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
39-365 |
3.47e-13 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 70.68 E-value: 3.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 39 ALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLA 118
Cdd:cd17320 21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 119 VGVASYTAPLYLSEIAPEKIRGSMISMyqLMITIGI-------LGAYLSDtafsyTGAWR---WMLGVIIIPaillligV 188
Cdd:cd17320 101 AAAGSVVARAIVRDLYSGAELAKIFSL--LMMILAIapalaplLGGLLLL-----FFGWRaifVFLALLGLL-------L 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 189 FFLpdsprwfaakrrfvdaerVLLRLRDTSAEAKReldeireslqvKQSGWALFKENSN-FRRAVFLGVLLQVMQQFTGM 267
Cdd:cd17320 167 LLL------------------VLLFLPETLPEEKR-----------KPLLSSLLRAYKRvLKNRRFLGYALALGLSFAGL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 268 NVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGmGVLGTMMHIGIHSPSA 347
Cdd:cd17320 218 FAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAA-ALVLLLAALLGGLSLW 296
|
330
....*....|....*...
gi 1191214456 348 QYFAIAMLLMFIVGFAMS 365
Cdd:cd17320 297 PLVAPLFLIFFGFGLIFP 314
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
12-335 |
4.69e-13 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 70.29 E-value: 4.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 12 KAMTFFVCFLAALAgllfgldIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAIL 91
Cdd:cd17474 1 LYAVFFATLLAVLG-------VSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 92 FVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYLSDTafsy 166
Cdd:cd17474 74 FGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGiavgpLLGGLLAAI---- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 167 tgAWRWMLGVIIIPAILLLIGVFFLPDSPRwfaakrrfvdaervllrlrdTSAEAKRELDEIRESLQvkqsgwalfkens 246
Cdd:cd17474 150 --SWRYPFFLLAALIPVAFLAILFLLPEPK--------------------EKAKSSSATKLRDLKKA------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 247 nFRRAVFLGVLLQVMQQFTGMNVIMYYAPKIFELAGYtnTTEQMWGTVIVGLTNVLATFIAIG---LVDRWGRKPTLTLG 323
Cdd:cd17474 195 -LRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYG--ISPIIIGLLFAGWSVLLALGSLFVgrlLKKRFGARRILVIG 271
|
330
....*....|..
gi 1191214456 324 FLVMAAGMGVLG 335
Cdd:cd17474 272 LLLYALSLLLLG 283
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
24-337 |
3.60e-12 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 67.62 E-value: 3.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 24 LAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAP 103
Cdd:cd17489 3 LANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 104 NVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-ILGAYLSDTAFSYTGAWrWMLGVIIIPAI 182
Cdd:cd17489 83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAmALGPALGLFLYQHLGFA-VLFIVAAVLAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 183 LLLIGVFFLPDSPRwfaakrrfvdaervllRLRDTSAEAKRELDEIREslqvkqsgwalfkensnfRRAVFLGVLLQVMq 262
Cdd:cd17489 162 LALLLVFLVKDPPP----------------VAAEEAEAGTRAFRRLVE------------------KKVLPPALILFLA- 206
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1191214456 263 qFTGMNVIMYYAPKIFELAGYTNTTEQMwgtVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGTM 337
Cdd:cd17489 207 -SIAYGAISTFLPLYAAERGISNAGLFF---TVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA 277
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
20-172 |
5.16e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 67.26 E-value: 5.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 20 FLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFS 99
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1191214456 100 AAAPNVEVLILSRVLLGlaVGVASYT--APLYLSEIAPEKIRGSMISMYQLMITIG-ILGAYLSDTAFSYTGAWRW 172
Cdd:cd17328 82 SFAPNFWQLLLFRALVG--IGEASYSpiAPTIIADLFPKEKRTRALGVFYFAIPLGsGLGYVVGGLVAQATGGWRW 155
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
64-449 |
7.53e-12 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 67.06 E-value: 7.53e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 64 GAAVGAVGSGWLSFKLGRKKS------LMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEK 137
Cdd:TIGR00887 68 GTLAGQLFFGWLADKLGRKRVygmeliIMIIATVASGLSPGSSPKSVMATLCFWRFWLGVGIGGDYPLSAIITSEFATKK 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 138 IRGSMISMYQLMITIGILG-------------------AYLSDTAFSYTGA----WRWMLGVIIIPAILLLIGVFFLPDS 194
Cdd:TIGR00887 148 WRGAMMAAVFAMQGFGILAgaivalivlagfkhsleaaADEASCTGSCVPAvdymWRILIGFGAVPALLALYFRLTIPET 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 195 PRWFA--AKRRFVDAERVLLRLRDTSAEAKRELDEIRESLQVKQSGWA-LFKENSNFRRA-VFLGV-----LLQVmqQFT 265
Cdd:TIGR00887 228 PRYTAdvAKDVEQAASDMSAVLQVKIEAEPDEVEKASTAVEVPKASWSdFFTHFFKWRHGkHLLGTagswfLLDI--AFY 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 266 GMNVimyYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIG-----------LVDRWGRKPTLTLGFLVMAAGMGVL 334
Cdd:TIGR00887 306 GVNL---NQKVILSAIGYSPPAATNNAYEELYKTAVGNLIIALAgtvpgywvtvfLVDIIGRKPIQLMGFFILTVLFFVL 382
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 335 GTMMHigiHSPSAQYFAIAMLLMFIVGFAMSAGPLIwvLCSEIQPLKGRDFGITCSTATNWIANmIVGATFLTMLNTLGN 414
Cdd:TIGR00887 383 GFAYN---HLSTHGFLAIYVLAQFFANFGPNATTFI--VPGEVFPTRYRSTAHGISAASGKAGA-IIGQFGFLYLAQHGD 456
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1191214456 415 A-----------NTFWVYAALNVLFILLTLwLVPETKHVSLEHIER 449
Cdd:TIGR00887 457 PtkgyptgiwmgHVLEIFALFMFLGILFTL-LIPETKGKSLEELSG 501
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
20-440 |
1.43e-11 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 65.78 E-value: 1.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 20 FLAALAG-LLFGLDIGVIAGALPFIADEFQITSHTqewvVSSMMFGAAVGAVG----------SGWLSFKLGRKKSLMIG 88
Cdd:cd17367 1 ILGGSVGnLVEWYDWYVYAAFALYFAPQFFPSGDP----TVALLSTAAVFAVGflmrpiggwlFGRLADRIGRRAALTLS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 89 AILFVAGSLFSAAAPNVE--------VLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLS 160
Cdd:cd17367 77 VSLMAAGSLVIAVTPTYAtigiwapiILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 161 DTAFSYT------GAWRWMLgviiipaILLLIGVFFLpdsprwfaakrrfvdaerVLLRLRDTSAEAkRELDEIRESLQV 234
Cdd:cd17367 157 LLVLQHTlgedqmAAWGWRI-------PFLLGGVLAV------------------VVLWLRRGLEET-ESFEAIAESNEA 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 235 KQSGWALFKensNFRRAVFLGVLLQvmqqfTGMNVIMY----YAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGL 310
Cdd:cd17367 211 SAGTLRELR---RHPRELLLVVGLT-----AGGTLAFYtwttYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 311 VDRWGRKPTLtLGFLVMAAgMGVLGTMMHIGIHSPSAQYFAIAMLLMFIVGFAMSAGPliwVLCSEIQPLKGRDFGITCS 390
Cdd:cd17367 283 SDRIGRRPLL-LFFGIGGT-LATVPLLSALDHTDSPYTAFALVLVGLVFLSGYTSINA---VVKAELFPTHVRALGVGLP 357
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 1191214456 391 TAtnwIANMIVGAT---FLTMLNTLGNANTFWVYAALNVLFILLTLWLVPETK 440
Cdd:cd17367 358 YA---LAVAIFGGTapyVALWLKSIGHEWVFFWYVAGLIAISLVVYLRMPETR 407
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
9-370 |
2.07e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 65.28 E-value: 2.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 9 RSNKAMTFFVCFLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIG 88
Cdd:COG2807 10 RSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 89 AILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIrGSMISMYQLMITIG-ILGAYLSDTAFSYT 167
Cdd:COG2807 90 LLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRV-GLMTGLYTAAMGLGaALAAGLTVPLAAAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 168 GaWRWMLGVIIIPAILLLigVFFLPDSPRWFAAKRRFVDAERVLLRLRDTSAeakreldeireslqvkqsgWALfkensn 247
Cdd:COG2807 169 G-WRGALAVWALLALLAL--LLWLPLLRRRPAAAAAAPAAASLRSLWRSPLA-------------------WLL------ 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 248 frrAVFLGVllqvmqQFTGMNVIMYYAPKIFELAGYTnTTEQMWGTVIVGLTNVLATFIAIGLVDRWG-RKPTLTLGFLV 326
Cdd:COG2807 221 ---TLFFGL------QSLLYYAVVAWLPPILRDAGLS-AATAGLLLSLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLL 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191214456 327 MAAGMGVLG------------------------TMMHIGIHSPSAQYFAIAMLLMFIVGFAMSA-GPLI 370
Cdd:COG2807 291 GLAGLLGLLlapgslpwlwavllglgqgglfplALTLIGLRARTPAEAAALSGMAQSVGYLLAAlGPLL 359
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
8-146 |
3.87e-11 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 64.60 E-value: 3.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 8 GRSNKAMTFFVCFLAALaglLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMI 87
Cdd:PRK11551 9 SSSRLALTIGLCFLVAL---LEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIV 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 88 GAILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMIS-MY 146
Cdd:PRK11551 86 SVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSlMY 145
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
67-439 |
3.96e-11 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 64.70 E-value: 3.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 67 VGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVE--------VLILSRVLLGLAVGVASYTAPLYLSEIAPEKI 138
Cdd:cd17368 55 IGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYAtigiaaplLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 139 RG---SMISMYQLMITI--GILGAYLSDT-AFSYTGAWRWMLgviiipaiLLLIGVFFLPdsprwfaakrrfvdaerVLL 212
Cdd:cd17368 135 RGfytSWQSASQQVAIVagALVGYLLSLTlTAEALAEWGWRI--------PFFIGLLIIP-----------------LGL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 213 RLRDTSAEAKRELDEIRESLqvKQSGWALFKENsnfRRAVFLGVLLQVMQQFTgMNVIMYYAPKIFELAGYTNTTEQMWG 292
Cdd:cd17368 190 WLRRSLEETEAFLERKARPT--RRELFALLANN---RRIILLGMLLVAGSTVT-FYFTTVYTPTYAKTVLGLSARDSFLV 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 293 TVIVGLTNVLATFIAIGLVDRWGRKPTL---TLGFLVMaagmgvLGTMMHIGIHSPSAQYFaIAMLLMFIVGFAMSAGPL 369
Cdd:cd17368 264 TLLAGVANFIWAPLGGALSDRIGRRPVLlviTLAALVT------LYPVFAWLTAAPSFGRL-LLVLLVLSFFFGMYGGAM 336
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1191214456 370 IwVLCSEIQPLKGRDfgiTCSTATNWIANMIVG------ATFLTMLNTLGNANTFWVYAAlnVLFILLTLWLVPET 439
Cdd:cd17368 337 V-VALVELFPVRVRS---TGFSLVYALAVAIFGgfaqfiVTWLIELTGSPLAPAWYLMGA--ALLGLLATLMLRET 406
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
16-222 |
6.84e-11 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 64.61 E-value: 6.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 16 FFVCFLAALAGllfGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAG 95
Cdd:TIGR01299 169 FFVLGLALMAD---GVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFF 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 96 SLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGilGAYLSDTA----------FS 165
Cdd:TIGR01299 246 AFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIG--GIYAAAMAwaiiphygwsFQ 323
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1191214456 166 YTGA-----WRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLRLRDTSAEAK 222
Cdd:TIGR01299 324 MGSAyqfhsWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKLIHDTNMRAK 385
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
21-192 |
2.46e-10 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 61.78 E-value: 2.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 21 LAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSA 100
Cdd:cd17372 3 YAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 101 AAPNVEVLILSRVLLGLAVGVASYTAPLYLsEIAPEKIRGSMISMYQLMITIG-ILGAYLSDTAFSYTGaWRWMLGVIII 179
Cdd:cd17372 83 FAPNYMWLIILRCLVGLGLGGGPQLASWYL-EFLPAKSRGTWMVLFSVFWTVGtIFEASLAWLVMPRLG-WRWLLAFSSV 160
|
170
....*....|...
gi 1191214456 180 PAILLLIGVFFLP 192
Cdd:cd17372 161 PSSLLLVFYRWTP 173
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
17-172 |
2.50e-10 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 62.26 E-value: 2.50e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 17 FVCFLAALAGLLFGLdigVIAGALPFIADEFQiTSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGS 96
Cdd:cd06179 1 AALCLAYFAQLFGVT---LPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGS 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191214456 97 LFSAAAPNVEVLILSRVLLGLAVGvASYTAPLYLSEIAPEKIRGSMIS-MYQLMITIGILGAYLSDTAFSYTGA-WRW 172
Cdd:cd06179 77 IVAGTAKSVNMLIGGQALIGIGAG-TQGLGAAVASELVPNKYRGLVQGvVNLVASPGSALGPLIAGALVEANAAgWRW 153
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
15-436 |
4.88e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 61.05 E-value: 4.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 15 TFFVCFLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVA 94
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 95 GSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-ILGAYLSdTAFSYTGAWRWM 173
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGaAIGPPLS-GWLLLLFGWRWA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 174 LGViiipailllIGVFFLPDSPRWFAAKRRFvdaervllrlrdtsaeakreldeireslqvkqsgWALFkensnfrrAVF 253
Cdd:cd17319 160 FII---------EGLLGLLLAVLWWFYLRQV----------------------------------WGLA--------LGY 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 254 LGVLlqvmqqfTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDR---WGRKPTLTLGFLVMAAG 330
Cdd:cd17319 189 FGIN-------YALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllrGARRLVIIIGLLLAAVG 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 331 MGVLGTMMHIgihspsaqyfAIAMLLMFIVGFAMSAG-PLIWVLCSEIQPLK--GRDFGITCSTAT--NWIANMIVGAtf 405
Cdd:cd17319 262 LLLAYLTTSP----------VVAVILLSLAGFGIGAAsPVFWSLPADLLPGEaaATAGGLINSGGNlgGFVAPLLIGY-- 329
|
410 420 430
....*....|....*....|....*....|.
gi 1191214456 406 ltMLNTLGNANTFWVYAALNVLFILLTLWLV 436
Cdd:cd17319 330 --LVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
19-172 |
1.04e-09 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 59.90 E-value: 1.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 19 CFLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLF 98
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191214456 99 SAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYLSdtafSYTGaWRW 172
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGpalgpIIGGFIT----QSLG-WRW 154
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
20-163 |
1.80e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.13 E-value: 1.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 20 FLAALAGLLFGLDIGVIAGALP-FIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLF 98
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 99 SAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYLSDTA 163
Cdd:cd17325 282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGmvlgpLLGGFLYDAF 351
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
16-236 |
2.44e-09 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 59.04 E-value: 2.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 16 FFVCFLAALAGllfGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAG 95
Cdd:cd17363 1 FFVLGLALMAD---GVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 96 SLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGilGAYLSDTAFS---------- 165
Cdd:cd17363 78 AFLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIG--GLYASAMAWAiiphygwgfs 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1191214456 166 -----YTGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLRLRDTSAEAKRELDEIRESLQVKQ 236
Cdd:cd17363 156 mgtayQFHSWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKHDEAWMILKQVHDTNMRAKGHPERVFTVSHIKR 231
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
2-172 |
6.95e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 57.58 E-value: 6.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 2 PDAKKQGRSNKAMTFFVCFLAALAGLLFGldigVIAGALPFIADEFQITSHTQE-WVVSSMMFGAAVGAVGSGWLSFKLG 80
Cdd:cd17473 186 PGAATAAALPWKRVLPIYFLAFLAMLLFY----VIPIQLPFLLQERGGGSAALIgLALAIASLAGAIGALLFGRLKRRLG 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 81 RKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----IL 155
Cdd:cd17473 262 KRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGqflspLV 341
|
170
....*....|....*..
gi 1191214456 156 GAYLSDTAFSYTGAWRW 172
Cdd:cd17473 342 LGPLVNLTGGLSGAFLI 358
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
1-170 |
1.02e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.81 E-value: 1.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 1 MPDAKKQGRSNKAMTFFVCFLAALAGLLFGLDIGVIAGALPFIAD-EFQITSHTQEWVVSSMMFGAAVGAVGSG-WLSFK 78
Cdd:cd17474 182 SSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLElLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKR 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 79 LGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLM--------- 149
Cdd:cd17474 262 FGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVrflgqavgp 341
|
170 180
....*....|....*....|.
gi 1191214456 150 ITIGILGAYLSDTAFSYTGAW 170
Cdd:cd17474 342 LLFGLLLEIFGLSAPFLVGAA 362
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
16-236 |
3.25e-08 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 55.69 E-value: 3.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 16 FFVCFLAALAGllfGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAG 95
Cdd:cd17440 1 FFVLGMALMAD---GVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 96 SLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGilGAYLSDTA----------FS 165
Cdd:cd17440 78 AFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIG--GIYASAMAwaiiphygwsFS 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1191214456 166 YTGA-----WRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLRLRDTSAEAKRELDEIRESLQVKQ 236
Cdd:cd17440 156 MGSAyqfhsWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKQIHDTNMRARGQPEKVFTVNRIKK 231
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
24-365 |
4.66e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 54.89 E-value: 4.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 24 LAGLLFGLDIGVIAGALPFIADEFQITSHTQ-EWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAA 102
Cdd:cd17473 6 LASTLTVMAGAAIAPALPAIAQHFVPNSELLvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 103 PNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYLSDTAfsytgaWRWMLGVI 177
Cdd:cd17473 86 DSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGgvvflLLGGALAEIG------WRAPFLVY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 178 IIPAILLLIGVFFLPDSPRwfaakrrfvdaervllrlrdTSAEAKRELDEIRESLQVKQSGWALFkensnfrrAVFLGVL 257
Cdd:cd17473 160 LLALPVLILVLLFLPEPAR--------------------KSKSAASPGAATAAALPWKRVLPIYF--------LAFLAML 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 258 LqvmqqftgMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGTm 337
Cdd:cd17473 212 L--------FYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLAL- 282
|
330 340
....*....|....*....|....*...
gi 1191214456 338 mhigihspsAQYFAIAMLLMFIVGFAMS 365
Cdd:cd17473 283 ---------ASGLWVVLLGAILAGLGFG 301
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
20-159 |
5.13e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.93 E-value: 5.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 20 FLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFS 99
Cdd:cd06173 212 LLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVL 291
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 100 AAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYL 159
Cdd:cd06173 292 GLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGAL 351
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
24-170 |
1.11e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 53.72 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 24 LAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAP 103
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191214456 104 NVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYTGAW 170
Cdd:cd17477 83 SPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL 149
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
67-369 |
1.33e-07 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 53.68 E-value: 1.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 67 VGAVGSGWLSFKLGRKKSLMI-----GAILFVAGSLFSAA-----APnvEVLILSRVLLGLAVGVASYTAPLYLSEIAPE 136
Cdd:cd17369 59 LGGVVFGHFGDRIGRKKTLVLtlllmGIATFLIGLLPTYAqigilAP--ILLVLLRLLQGLALGGEWGGAVLMAVEHAPP 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 137 KIRGSMISMYQLMITIG---------ILGAYLSDTAFSytgAWRWMLgviiipaillligvfflpdsPRWFAAkrrFVDA 207
Cdd:cd17369 137 KRRGFYGSFPQLGAPVGlllatgvflLLSALLSDEAFL---SWGWRI--------------------PFLLSA---VLVA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 208 ERVLLRLRDTSAEAKRELDEIREslQVKQSGWALFKENsnfRRAVFLGVLLQVMQQ---FTGMNVIMYYAPKIFELAGYT 284
Cdd:cd17369 191 VGLYIRLRLEETPVFRRAKEAGQ--VVRAPLVEVLRRH---WRALLLAIGLRLAENvlfYLFTTFALSYATQTLGVDRST 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 285 NTTEQMWGTVIVGLTNVLATFIAiglvDRWGRKPTltlgFLVMAAGMGVLGTMMHIGIHSPSAQYFAIAMLLMFIVGFAM 364
Cdd:cd17369 266 VLLAVLIASVVAAITIPLFGWLS----DRVGRRPV----YLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGM 337
|
....*
gi 1191214456 365 SAGPL 369
Cdd:cd17369 338 MYGPQ 342
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
49-405 |
1.89e-07 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 53.02 E-value: 1.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 49 ITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPL 128
Cdd:cd17327 38 LVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFIL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 129 YLSEIAPEKIRGSMISMYQLMITIG-ILGAYLSDTAFSYTGA-----WRWM-LGVIIIPAILLLIGVFFLPDSP--RWFa 199
Cdd:cd17327 118 YLGMWYKREEQAKRIAFFYAAAGLGsIFGGLLAYGVFKILGVgglagWRWLfIIEGLITIIIGLVIFFWLPDNPskAWF- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 200 akrrFVDAERVLlrlrdtsaeAKRELDEIRESLQVKQSGWALFKEnsNFRRAVFLGVLLQVMQQFTGMNVIMYYAPKIFE 279
Cdd:cd17327 197 ----LTEEEKEL---------AVERLRANQTGKGDQKFKWKQIKE--AFKDPRTWLLFLFFFCSQITNNGISNFLPLILK 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 280 LAGYTNTTEQMWgTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAagmgVLGTMMHIGIHSPSAQYFAIAMLLMfi 359
Cdd:cd17327 262 SLGFYSLQTNLL-SVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLA----LVGSIILLAAPNPPGAYFAAYILGG-- 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1191214456 360 vGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATF 405
Cdd:cd17327 335 -GSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAPQIF 379
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
39-122 |
2.03e-07 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 52.94 E-value: 2.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 39 ALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFS--AAAPNVEVLILSRVLLG 116
Cdd:cd17380 21 AIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTplLAYSSLPLLILSRILLG 100
|
....*.
gi 1191214456 117 LAVGVA 122
Cdd:cd17380 101 LGEGVH 106
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
15-123 |
2.04e-07 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 52.77 E-value: 2.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 15 TFFVCFLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVA 94
Cdd:TIGR00710 3 AKAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFAL 82
|
90 100
....*....|....*....|....*....
gi 1191214456 95 GSLFSAAAPNVEVLILSRVLLGLAVGVAS 123
Cdd:TIGR00710 83 SSLGLALSNNIETLLVLRFVQAFGASAGS 111
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
16-228 |
3.84e-07 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 52.23 E-value: 3.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 16 FFVCFLAALAGllfGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAG 95
Cdd:cd17438 1 FFVLGLALMAD---GVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 96 SLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGilGAYLSDTAFS---------- 165
Cdd:cd17438 78 AFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIG--GLYASAMAWSiiphygwgfs 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191214456 166 -----YTGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLRLRDTSAEAKRELDEI 228
Cdd:cd17438 156 mgtnyHFHSWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDEAWMILKNIHDTNMRAKGTPEKV 223
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
20-173 |
4.04e-07 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 52.39 E-value: 4.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 20 FLAALAG-LLFGLDIGVIAGALPFIADEFQITSHTQEWVVS----SMMFGA-AVGAVGSgwlsfKLGRKKSLMIGAILFV 93
Cdd:PRK03893 22 FSAAWLGyLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISaafiSRWFGGlLLGAMGD-----RYGRRLAMVISIVLFS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 94 AGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIR----GSMISMYQlmitigiLGAYLSDTAFSY--- 166
Cdd:PRK03893 97 VGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRnkasGFLISGFS-------IGAVVAAQVYSLvvp 169
|
....*..
gi 1191214456 167 TGAWRWM 173
Cdd:PRK03893 170 VWGWRAL 176
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
39-176 |
1.69e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 50.07 E-value: 1.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 39 ALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLA 118
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIF 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1191214456 119 VGVASYTAPLYLSEIAPEKIRGSMISMYQLMITI-GILGAYLSDTAFSYTGAWRWMLGV 176
Cdd:TIGR00881 97 QGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIV 155
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
20-153 |
2.03e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.90 E-value: 2.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 20 FLAALAGLLFGLDIGVIAGALP-FIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSL- 97
Cdd:COG2211 231 LLLLLAYLLFFLALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLl 310
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1191214456 98 -FSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAP-------EKIRGSMISMYQLMITIG 153
Cdd:COG2211 311 lFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLG 374
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
41-197 |
3.71e-06 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 49.04 E-value: 3.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 41 PFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLAVG 120
Cdd:cd17441 23 PQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIG 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191214456 121 VASYTAPLYlSEIAPEKIRGSMISMYQLMITIG-ILGAYLSDTAFSYTGaWRWMLGVIIIPAILLLIGVFFLPDSPRW 197
Cdd:cd17441 103 GVPQSVTLY-AEFLPMKSRAKCILLIEVFWALGtVFEVLLAVFVMPTLG-WRWLLILSALPLLIFAVLCFWLPESARY 178
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
20-236 |
4.80e-06 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 48.87 E-value: 4.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 20 FLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFS 99
Cdd:cd17439 2 FVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 100 AAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGilGAYLSDTAFSYT------------ 167
Cdd:cd17439 82 SFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIG--GIYASAMAWAIIphygwsfqmgsa 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1191214456 168 ---GAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLRLRDTSAEAKRELDEIRESLQVKQ 236
Cdd:cd17439 160 yqfHSWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKR 231
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
73-435 |
5.06e-06 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 48.65 E-value: 5.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 73 GWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEV--------LILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMIS 144
Cdd:PRK10406 84 GRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETigtwapalLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYAS 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 145 mYQLMITIG----------ILGAYLSDTAFSytgAWRWMLGVIIIPAILLligvfflpdsprwfaakrrfvdaerVLLRL 214
Cdd:PRK10406 164 -FQYVTLIGgqllallvvvVLQQTLEDAELR---EWGWRIPFALGAVLAV-------------------------VALWL 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 215 RdtsaeakRELDEI--RESLQVKQSGwaLFKENSNFRRAvFLGVLlqvmqQFTGMNVIMYYAPKIFELAGYTNTTEQMWG 292
Cdd:PRK10406 215 R-------RQLDETsqQETRALKEAG--SLKGLWRNRRA-FIMVL-----GFTAAGSLCFYTFTTYMQKYLVNTAGMHAN 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 293 TVIVGLTNVLATFIAI-----GLVDRWGRKPTLtLGFLVMAAGMGVLGTMMHIGIHSPSAQyFAIAMLLMFIVGFAMSag 367
Cdd:PRK10406 280 VASGIMTAALFVFMLIqpligALSDKIGRRTSM-LCFGSLAALFTVPILSALQNVSSPYAA-FGLVMCALLIVSFYTS-- 355
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1191214456 368 pLIWVLCSEIQPLKGRDFGITCSTAtnwIANMIVG--ATFLTM-LNTLGNANTF-WVYAALNVLFILLTLWL 435
Cdd:PRK10406 356 -ISGILKAEMFPAQVRALGVGLSYA---VANALFGgsAEYVALsLKSIGMETAFfWYVTLMAVVAFLVSLML 423
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
61-435 |
5.13e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 48.38 E-value: 5.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 61 MMFGAAVGAVGsGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSR-VLLGLAVGVAsYTAPLYLS-EIAPEKi 138
Cdd:cd17353 48 IVFLAISAPFA-GRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYgVLGGIGAGIG-YITPVSTAvKWFPDK- 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 139 RGsMISMyqlMITIG-----ILGAYLSDTAFSYTGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLR 213
Cdd:cd17353 125 RG-LATG---IVIAGfglgsLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENS 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 214 LRDTSAeakreldeiRESLQVKQsGWALFKensnfrrAVFLGVllqvmqqFTGMNVIMYYAPKIFELAGYTNTTEQMWGT 293
Cdd:cd17353 201 PRDYTP---------REMLRTPT-FWLLWL-------MFFLNA-------TAGLMLIGQAKPIGQEFAGLDAGIAALAVS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 294 VIvGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLgtmmhigihSPSAQYFAIAMLLMFIVGFAMSAG-PLIWV 372
Cdd:cd17353 257 IL-SIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLL---------PFIGSVAVLFVLGVALIGFCYGGGfALFPA 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1191214456 373 LCSEIQPLK--GRDFGIT-CSTAtnwIANMIVGATFLTMLNTLGNANTFWVYAALNVLFILLTLWL 435
Cdd:cd17353 327 LTADFFGTKnaGTNYGLLyTAKG---VGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-155 |
6.84e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.80 E-value: 6.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 20 FLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSL---MIGAILFVAGS 96
Cdd:pfam07690 203 LWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLllaLLLLILAALGL 282
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1191214456 97 LFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGIL 155
Cdd:pfam07690 283 LLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGA 341
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
27-121 |
1.23e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 47.32 E-value: 1.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 27 LLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVE 106
Cdd:cd17333 6 FSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85
|
90
....*....|....*
gi 1191214456 107 VLILSRVLLGLAVGV 121
Cdd:cd17333 86 LFVVLMFLAGLGAGI 100
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
39-159 |
1.33e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 47.22 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 39 ALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLA 118
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1191214456 119 VGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYL 159
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIApllapIIGGWL 138
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
286-457 |
2.07e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.45 E-value: 2.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 286 TTEQMWGTVIVGL-------TNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLGTMMHIgihspsaqYFAIAMLLMF 358
Cdd:cd17329 27 HQQLGLSASIVGLvlalsavAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSP--------WLFAIALVLT 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 359 IVGFAMSAgPLIWVLCSEIQPLKGRDFGITCStatNWIAN--MIVGATFLTMLNTLGNANTFWVYAALNVLFILLTLWLV 436
Cdd:cd17329 99 GFGGGLFE-PASEAMIADVTTPENRTRAFSLL---YWAINlgVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLL 174
|
170 180
....*....|....*....|.
gi 1191214456 437 PETKHVSLEHIERNLMKGRKL 457
Cdd:cd17329 175 PETRPKRRAAEKTEILRGYKI 195
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
9-174 |
2.31e-05 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 46.97 E-value: 2.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 9 RSNKAMTFFVCFLAALAGLLFGLDIGviAGALPFIADEFQiTSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIG 88
Cdd:pfam06609 38 RSPRIIASFAAFSLNVCATYFVLQAS--ASALPNILQDIG-QSENQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIAT 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 89 AILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASyTAPLYLSEIAPEKIR--GSMISMYQLMITIGiLGAYLSDTaFSY 166
Cdd:pfam06609 115 HIIGLVGAIVGCTANKFNTLLAAMTLLGVAAGPAG-ASPLFIGELMSNKTKflGLLIVSAPTIAMNG-AGPYFGQR-LAI 191
|
....*...
gi 1191214456 167 TGAWRWML 174
Cdd:pfam06609 192 QGNWRWIF 199
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
246-460 |
2.72e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.12 E-value: 2.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 246 SNFRRAVFLGVLLQVMQQFTGMNVIMYYAPKIFELAGYTNTTEQmWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFL 325
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAG-LVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 326 VMAAGMGVLGTmmhigihspsAQYFAIAMLLMFIVGFAMSAG-PLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGAT 404
Cdd:COG2814 84 LFALGSLLCAL----------APSLWLLLAARFLQGLGAGALfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLL 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1191214456 405 FLTMLNTLGNANTFWVYAALNVLFILLTLWLVPETKHVSLEHIERNLMKGRKLREI 460
Cdd:COG2814 154 GGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRL 209
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
56-160 |
3.78e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 45.65 E-value: 3.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 56 WVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASyTAPLYLSEIAP 135
Cdd:cd17330 38 LLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVS-VAQAYIADITD 116
|
90 100 110
....*....|....*....|....*....|
gi 1191214456 136 EKIRGSMISMYQLMITIG-----ILGAYLS 160
Cdd:cd17330 117 EEERAKAFGIISAAFGLGfilgpALGGFLS 146
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
59-173 |
1.19e-04 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 43.88 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 59 SSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKI 138
Cdd:cd17379 40 SSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKY 119
|
90 100 110
....*....|....*....|....*....|....*
gi 1191214456 139 RGSMISMYQLMITIGILgaYLSDTAFsYTGAWRWM 173
Cdd:cd17379 120 RRTVGIVYQMFFTLGLL--ILPGIAY-FIPHWRWL 151
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
73-116 |
1.51e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 43.74 E-value: 1.51e-04
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 1191214456 73 GWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLG 116
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG 96
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
56-335 |
2.21e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.37 E-value: 2.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 56 WVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAP 135
Cdd:cd17329 39 LVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTT 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 136 EKIRGSMISMYQLMITIG-----ILGAYLSDTAFSYTgawrwmlgviiipaILLLIGVFFLpdsprwFAAkrrfvdaerV 210
Cdd:cd17329 119 PENRTRAFSLLYWAINLGvaigpLLGGLLLLYSFRLL--------------FLAAAVLFLL------AAL---------V 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 211 LLRLRDTSAEAKRELDEIRESlqvkqSGWALFKENSNFRRAVFLGVLLQVMQQFTGMNVIMYYAPKIFelagytnTTEQM 290
Cdd:cd17329 170 LLFLLPETRPKRRAAEKTEIL-----RGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILG-------LGESL 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1191214456 291 WGTV--IVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLG 335
Cdd:cd17329 238 LGLLlaLNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLA 284
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
25-171 |
2.60e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 43.00 E-value: 2.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 25 AGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLG---RKKSL----MIGAILFVAGSL 97
Cdd:cd17475 207 GALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggrRRPVLvitaAIAAAALLVLSL 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191214456 98 FSAAAPNVEVLILSrVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGA-----YLSDTAFSYTGAWR 171
Cdd:cd17475 287 LSPGTPLWLLVLLL-ILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGpplfgLLVDATHSYAPAWL 364
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
34-379 |
3.28e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.93 E-value: 3.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 34 GVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGaILFVAGSLFSAA-APNVEVLILSR 112
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLG-PLLTGLGLSLLGfAPNYWLLLLLV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 113 VLLGLAVGVASYTAPLYLSEIAPEKiRGSMISMYQLMITIG-----ILGAYLSdTAFSYTGAWRWMLGVIIIPAIlllig 187
Cdd:cd17478 92 ALAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGfalgpLIAAALV-ALFGGLGLLILLIIPGLAVAL----- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 188 vfflpdsprwfaakrrfvdaerVLLRLRDTSAEAKRELDEIRESLQVKQSGWalfkensnfrRAVFLGVLLQVMQQFTGM 267
Cdd:cd17478 165 ----------------------LLLRLRPLKKPEAKKAAAKSSARSTLKGVW----------RALLLLLIIVFLRSWVLS 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 268 NVIMYYaPKIFELAGYTNTTEQMWGTVIVgLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAAGMGVLgtmmhigihsPSA 347
Cdd:cd17478 213 SLTTFL-PFYLVQRGYSLVFAGLLLSLFL-FAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLF----------LLT 280
|
330 340 350
....*....|....*....|....*....|..
gi 1191214456 348 QYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQP 379
Cdd:cd17478 281 PGIWSYILLVLAGFLLFASFPVTVVLAQELLP 312
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
254-453 |
3.36e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 43.00 E-value: 3.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 254 LGVLLQVMQQFTGMNVIMYYAPKIFELAGytNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPtltlgFLVMAAGMGV 333
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLG--PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRW-----FFIGGNLLGV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 334 LGtmmhiGIHSPSAQYFAIAMLLMFIVGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMI--VGATFLTMLNT 411
Cdd:cd06179 74 VG-----SIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALgpLIAGALVEANA 148
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1191214456 412 LGNANTFWVYAALNVL-FILLTLWLVPETKHVSLEHIERNLMK 453
Cdd:cd06179 149 AGWRWIFYINAIFNALaLILLFFFYHPPPRPQLHGSSTRQKLK 191
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
41-159 |
3.88e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.53 E-value: 3.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 41 PFIADEFQITSHTQEWVVSSMMFGAAVGAVGS---GWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGL 117
Cdd:cd17370 220 AFLILRAQELGLSAALIPLLYALFNLVYALAAypaGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGL 299
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1191214456 118 AVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYL 159
Cdd:cd17370 300 YMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASL 341
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
65-435 |
3.91e-04 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 42.49 E-value: 3.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 65 AAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSL----FSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRG 140
Cdd:cd17337 45 VAIASWLSGVLAELFGPRRVMLIGLIIWLVFEVlflaFGLPSHNYPLMLLTYGLRGFGYPLFAYSFLVWITYRTPAERLG 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 141 SMISMYQLMITIG--ILGAYLSDTAFSYTGAwrwmLGVIIIPAILLLIGVFFlpdsprwfaakrrfvdaerVLLRLRDTs 218
Cdd:cd17337 125 SAVGWFWFAFTGGlpVLGSYLASFTIPVIGE----IGTLWLSLVFVALGGLI-------------------ALFLVRDR- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 219 AEAKRELDEIRESLQVKQSGWALFKENsnfrRAVFLGVLLQVMQQFT--GMNVIM--YYAPKIfelaGYTnTTE--QMWG 292
Cdd:cd17337 181 TGEQPLANPSEEPLKELLSGITILFRN----PKIAIGGIVRIINTLSqfGFPVFMplYFTDTG----GFS-TSQwlQIWG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 293 tvIVGLTNVLATFIAIGLVDRWGRKPTLTL-GFLVMAAGMGVLGTMMHIGIHSpsaqyFAIAMLLMFIVGFAMSA-GPLI 370
Cdd:cd17337 252 --IIFLVNIFFNLIFGILGDKIGWRRTVRWfGGVGCAISTLLFYYVPQLFGHN-----YWAALIAAILFGIGLAGfVPLS 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191214456 371 WVLCSEIQPLKGRDFGITC--STATNWIANMIVGAtfltMLNTLGNANTFWVYAALNVLFILLTLWL 435
Cdd:cd17337 325 ALMPSLAPEHKGAAMSILNlgAGLSNFVGPAIVTL----FLGSFGAGGVVWIFAGLYLLSAVLTLFL 387
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
78-176 |
3.94e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.60 E-value: 3.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 78 KLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGA 157
Cdd:cd17329 262 RFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIG 341
|
90
....*....|....*....
gi 1191214456 158 YLSDTAFSYTGAWRWMLGV 176
Cdd:cd17329 342 PLVGGLLLDLLGPGLPWLI 360
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
20-173 |
5.56e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 41.86 E-value: 5.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 20 FLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSmmFGAAVGA--VGSGWLSFKLGRKKSLMIGAILFVAGSL 97
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAAS--YSLTVGTfiLIFGRLGDIYGHKKMFVIGSFWFAIWSL 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191214456 98 FSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMI-SMYQLMITIG-ILGAYLSDTaFSYTGAWRWM 173
Cdd:cd17476 79 IAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVfSLFGATAPLGfALGGVFGGL-FAQLAWWPWI 155
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
31-117 |
7.65e-04 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 41.64 E-value: 7.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 31 LDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIL 110
Cdd:PRK10504 24 LDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLL 103
|
....*..
gi 1191214456 111 SRVLLGL 117
Cdd:PRK10504 104 ARVLQGV 110
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
229-373 |
7.94e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.81 E-value: 7.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 229 RESLQVKQSGWALFKeNSNFRRAVFLGVLLQVMQQFTGMnVIMYYAPKIFELagytNTTEQMWGTVIVGLTNVLATFIAI 308
Cdd:COG2211 212 EEKVSLKESLKALLK-NRPFLLLLLAYLLFFLALALVAA-LLLYYFKYVLGL----SAALVGLLLALYFLAALLGAPLWP 285
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1191214456 309 GLVDRWGRKPTLTLGFLVMAAGMGVLGTMmhigihspSAQYFAIAMLLMFIVGFAMSA-GPLIWVL 373
Cdd:COG2211 286 RLAKRFGKKKAFIIGLLLAALGLLLLFFL--------GPGNLWLLLVLAALAGIGLGAiLVLPWAM 343
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
34-176 |
8.70e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 41.68 E-value: 8.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 34 GVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRV 113
Cdd:COG2270 256 TVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGL 335
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191214456 114 LLGLAVG---VASYTaplYLSEIAPEKIRGSMISMYQLMITI-GILGAYLSDTAFSYTGAWRWMLGV 176
Cdd:COG2270 336 LIGLVMGgiqALSRS---LLARLIPPGREAEFFGLYALSGKAaSFLGPLLFGLVTQLTGSQRLGILS 399
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-170 |
1.07e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.26 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 18 VCFLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLS-FKLGRKKSLMIGAILFVAGS 96
Cdd:cd06174 205 LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSdRLIGRKPLLLIGLLLMALGL 284
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191214456 97 LFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYLSDTAFSYTGAW 170
Cdd:cd06174 285 ALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGgaigpLLAGFLLAATFGLTGAF 363
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
20-155 |
1.23e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.05 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 20 FLAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSF-KLGRKKSLMIGAILFVAGSLF 98
Cdd:cd17490 198 FFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYkKLGERNTIIIGFLLLGAYCFL 277
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 99 SAAAPNVEVLILSRVLLGLAVGVASytaPLYLS---EIAPEKIRGSMISMYQLMITIGIL 155
Cdd:cd17490 278 IPFAPNLTLLYLLQALNGFGTGILF---PLLMSlsiEGVPAEQRSTAMGFFQAIYALGMF 334
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
14-145 |
1.34e-03 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 40.78 E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 14 MTFFVCFLAALAgLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFV 93
Cdd:PRK10473 1 MSRFLLCSFALV-LLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFI 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1191214456 94 AGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISM 145
Cdd:PRK10473 80 IASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSL 131
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
25-176 |
2.72e-03 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 39.79 E-value: 2.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 25 AGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPN 104
Cdd:cd17442 9 TGVAEAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPS 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1191214456 105 VEVLILSRVLLGlaVGVASYTAPLYL-SEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYTGAWRWMLGV 176
Cdd:cd17442 89 YIWFVFLRCMVG--CGVSGHSQGLIIkTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRF 159
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
13-170 |
2.84e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.87 E-value: 2.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 13 AMTFFVCFLAALAGLLFGL-------------------DIGVIAGALPFIADEFQITSHTQEWVVSSM-MFGAAVGAVGS 72
Cdd:cd17330 152 ALPFLVAAALALLNLVLVLfflpplrrlllvyflialaFAGLESVFSLFLKDRFGFSPSQIGLLLALVgIAGILAQLLLI 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 73 GWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITI 152
Cdd:cd17330 232 PRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSL 311
|
170
....*....|....*....
gi 1191214456 153 G-ILGAYLSDTAFSYTGAW 170
Cdd:cd17330 312 ArIIGPLLAGPLYSFLGPG 330
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
57-159 |
2.94e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.85 E-value: 2.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 57 VVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSrVLLGLAVGVASYTAPLYLSEIAPE 136
Cdd:cd17478 235 LLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQELLPG 313
|
90 100
....*....|....*....|....*
gi 1191214456 137 KIrgSMIS--MYQLMITIGILGAYL 159
Cdd:cd17478 314 NV--GLASglMMGLSFGLGGIGAPV 336
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
57-170 |
3.12e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 39.82 E-value: 3.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 57 VVSSMMFGAAVGAVG---SGWLSFKLGRKKSLMIGAILFV--AGSLFSAAAPNVEVLILSRVLLGLAVGVASYTAPL--Y 129
Cdd:cd17369 266 VLLAVLIASVVAAITiplFGWLSDRVGRRPVYLAGALLAAlfAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQaaF 345
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1191214456 130 LSEIAPEKIRGSMISM-YQLmitIGILGA----YLSDTAFSYTGAW 170
Cdd:cd17369 346 LAELFPTRVRYTGASLgYQL---GAILGGgfapLIATALVAATGSW 388
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
23-134 |
3.32e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 39.51 E-value: 3.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 23 ALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSL--FSA 100
Cdd:cd17332 227 LLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLllFFL 306
|
90 100 110
....*....|....*....|....*....|....
gi 1191214456 101 AAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIA 134
Cdd:cd17332 307 PPGNLVLILVLAVLAGIGYGGANLLPWAMLADVI 340
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
20-176 |
3.54e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 39.53 E-value: 3.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 20 FLAALAGLLFGLDIGVIAgalPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFS 99
Cdd:cd17475 2 TLAQAAASLVAQGIPALA---PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLM 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191214456 100 AAAPNVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYTGAWRWMLGV 176
Cdd:cd17475 79 ALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVV 155
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
39-122 |
3.79e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 39.51 E-value: 3.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 39 ALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLA 118
Cdd:PRK11652 30 AIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLG 109
|
....
gi 1191214456 119 VGVA 122
Cdd:PRK11652 110 TGVG 113
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
11-123 |
4.00e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 39.49 E-value: 4.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 11 NKAMTFFVCFLAALAGLLFgLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAI 90
Cdd:PRK11043 1 MQPSKGFLVYLAGLSMLGF-LATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLS 79
|
90 100 110
....*....|....*....|....*....|...
gi 1191214456 91 LFVAGSLFSAAAPNVEVLILSRVLlgLAVGVAS 123
Cdd:PRK11043 80 LFALGSLGMLWVESAAQLLVLRFV--QAVGVCS 110
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
21-361 |
5.82e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 38.79 E-value: 5.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 21 LAALAGLLFGLDIGVIAGALPFIADEFQITSHTQEWVVSSMMFGAAVGAVGS---GWLSFKLGRKKSLMIGAILFVAGSL 97
Cdd:cd17355 4 VLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQpfvGRLLDRFGPRRVMLLGLLLLAAGLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 98 FSAAAPNVEVLILSRVLL-GLAVGVASYTAPLYLSEIAPEKIRGsmismyqLMITIGILGAYLSDTAFSYTGA------- 169
Cdd:cd17355 84 LLALATSLWQLYLLWGLLgGGGAGTLAAVAFATVAAWWFERRRG-------LALGILTAGGGLGSLVFLPLGAalieafg 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 170 WRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFVDAERVLLRLrdTSAEAKReldeireslqvkqsgwalfkeNSNFR 249
Cdd:cd17355 157 WRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGS--TLKEALR---------------------SASFW 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 250 RaVFLGVLLQVMQqftgMNVIMYYAPKIFELAGYTnTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAA 329
Cdd:cd17355 214 L-LALAFFLCGFA----VVGLIVHLVPYLADRGIS-PAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRAL 287
|
330 340 350
....*....|....*....|....*....|..
gi 1191214456 330 GMGVLgtmmhIGIHSPSAQYFAIAMLLMFIVG 361
Cdd:cd17355 288 GLALL-----LLLPFPPLALLLFAALFGLGWG 314
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
27-145 |
7.15e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 38.74 E-value: 7.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 27 LLFGLDIGVIAGALPFIA-DEFQITSHTQEWVVS-SMMFGAAVGAVGSGWLSfKLGRKKSLMIGA-ILFVAGSLFSAAAP 103
Cdd:cd17331 217 LLSGLPIGMFQSMFSLVAmDFFGLTPEENGYLMSyAGVLGMVVQGLLVGPLT-KRFGERSLLKLSvALLAIGYLLLAFVT 295
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1191214456 104 NVEVLILSRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISM 145
Cdd:cd17331 296 TVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGL 337
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
73-162 |
9.76e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 37.98 E-value: 9.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191214456 73 GWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLILSRVLLGLaVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITI 152
Cdd:cd17390 52 GSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGI-FKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSL 130
|
90
....*....|....*
gi 1191214456 153 G-----ILGAYLSDT 162
Cdd:cd17390 131 GfilgpVVGGHLAET 145
|
|
| |
